ライフサイエンスコーパス: decreased activity

1 dition of phosphatidylinositol significantly decreased activity.

2 nge, while mock-immunized hamsters displayed decreased activity.

3 herence, while disruption of Hpt resulted in decreased activity.

4 increased NREM time, decreased REM time, and decreased activity.

5 oped in the bottle-fed group, accompanied by decreased activity.

6 , direct attachment of an amino group led to decreased activity.

7 e obesity is associated with hyperphagia and decreased activity.

8 sulfoxides or sulfones leads to compounds of decreased activity.

9 ha during increased activity and beta during decreased activity.

10 up to the lumazine by one carbon resulted in decreased activity.

11 e to intrinsic or extrinsic factors leads to decreased activity.

12 over, substitution with hydrophilic moieties decreased activity.

13 aliphatic chain (making a Val) also greatly decreased activity.

14 into CR1b resulted in EBNA-LP with slightly decreased activity.

15 Its replacement by an amino group led to decreased activity.

16 quitination and protein turnover, as well as decreased activity.

17 ilarly, whereas a nonphosphorylatable mutant decreased activity.

18 eased Rc3h1 promoter activity, whereas IKZF2 decreased activity.

19 tives with increased steric volume exhibited decreased activities.

20 ut the double cysteine mutant had a modestly decreased activity (1.75 +/- 0.14 micromol of NO min(-1)

21 = mildly decreased activity, 2 = moderately decreased activity, 1 = severely decreased activity, and

22 ng criteria: 4 = normal activity, 3 = mildly decreased activity, 2 = moderately decreased activity, 1

23 ) sedentary, no change (referent group), (2) decreased activity, (3) increased activity, and (4) acti

24 Only wild-type iNOS had decreased activity (42 +/- 2%) after reaction with 50 mi

25 Decreased activity (66% of control) of dihydroxyacetonep

26 ated nNOS with H2S under turnover conditions decreased activity after dilution by approximately 70%,

27 lity to generate long-term immune memory and decreased activities against tumour-cell subpopulations

28 (10.5% non-WT), whereas posaconazole showed decreased activity against C. albicans (4.4%) and Candid

29 HF lacking the hydroxyl moiety substantially decreased activity against HIVDRV(R) .

30 ant activity laccase treatment resulted in a decreased activity and also of that for red wines.

31 onset SMA characterized by muscle weakness, decreased activity and an alteration of the muscle fiber

32 tion of the most C-terminal of these domains decreased activity and caused enzyme aggregation and ins

33 consistent micrographia was associated with decreased activity and connectivity in the basal ganglia

34 e effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key c

35 f capacity for anchorage-independent growth, decreased activity and expression of matrix metalloprote

36 Decreased activity and expression of the cardiac sarcopl

37 ynthesizing enzyme NAPE-phospholipase D, and decreased activity and expression of the OEAdegrading en

38 an FA-HFD males, and all males on HFD showed decreased activity and increased anxiety, whereas female

39 The progressive relationship between decreased activity and increased PEG size suggests that

40 ymorphic, with long repeat lengths linked to decreased activity and inducibility.

41 The 105I variant has decreased activity and lower protein levels than the 105

42 ased activity of the lipid phosphatase PTEN, decreased activity and phosphorylation (Ser(473)) of Akt

43 chronic exposure of endothelial cells to NO decreased activity and protein levels of complexes I, II

44 creased proximal phosphate reabsorption, and decreased activity and protein of the principal renal ph

45 of nighttime quiescence, Cassiopea exhibited decreased activity and reduced responsiveness to a senso

46 ad potent antiviral activity, in contrast to decreased activity and selectivity observed for 2'-deoxy

47 Replacement of the CXXC motif led to decreased activity and stability according to hemolysis

48 same phosphate as N229, had a significantly decreased activity and substrate binding.

49 rom Methanocaldococcus jannaschii showed 76% decreased activity and the MjE102Q mutation completely a

50 Decreased activity and/or gradual loss of the identified

51 moderately decreased activity, 1 = severely decreased activity, and 0 = no activity.

52 lacking the basic nitrogen (3i and 6d), show decreased activity at all monoamine transporters, though

53 ubstitution resulted in several analogs with decreased activity at alpha3(*) versus alpha6(*) nAChRs

54 ariably followed by a DC voltage shift and a decreased activity at both low (30-57 Hz)- and high (63-

55 to up-regulate macroautophagy, and in fact, decreased activity at late time points.

56 rd transfection doses, but had substantially decreased activity at lower dosing levels.

57 subjects, unmedicated MDD subjects exhibited decreased activity bilaterally in the dorsal mid-insula

58 ty but also display tendon calcification and decreased activity, body weight, and longevity.

59 ormer toward template RNA and results in its decreased activity both in de novo RNA synthesis and in

60 eduction of the acetylene to an ethyl moiety decreased activity, both in functional and binding assay

61 sulfate (GSSG) ratio was associated with the decreased activity, but not protein content, of glucose

62 ) forms disulfide-bonded dimers that exhibit decreased activity, but retain the ability to bind asial

63 s, whereas deletion of part of the stem-loop decreased activity by 100-fold, and deletion of the dist

64 ution of a Ser for either Cys-186 or Cys-406 decreased activity by 20-fold and abrogated the response

65 Decreased activity can result from conductive hearing lo

66 The Ala893 variant has decreased activity compared with the 893Ser variant; the

67 re to the cocaine-conditioned context showed decreased activity compared with the vehicle control gro

68 l1a1-luciferase constructs, mutation of YY1A decreased activity completely (wild-type p350 (p350wt),

69 tein-a histone acetyltransferase (HAT) whose decreased activity contributes to polyQ disease.

70 This decreased activity correlated with reduced Sp1 protein a

71 protein multimerization, exhibited severely decreased activity, demonstrating that E4-ORF3 self-asse

72 els in mouse primary cortical neurons led to decreased activity-dependent BDNF expression.

73 we found that the L1CAM mutation selectively decreased activity-dependent Na(+)-currents, altered neu

74 arrying the Met allele, which is linked with decreased activity-dependent neuroplasticity.

75 we defined PCC and vACC regions that showed decreased activity during a cognitive (working memory) t

76 creased activity during social judgments and decreased activity during nonsocial judgments.

77 hyperactive, PGC-1beta KO mice show greatly decreased activity during the dark cycle.

78 linical symptoms such as coughing, sneezing, decreased activity, fever, and labored breathing in chal

79 As a group, Type I neurons had a period of decreased activity following termination of the distendi

80 d in the formation of disulfide bonds and in decreased activities for the wild-type and C56S/C242S en

81 dazole ring during redox cycling and greatly decreased activity for the H86Y variant.

82 activity as aware errors, in comparison with decreased activity for unaware errors.

83 ivity group; and 0.49 (0.26 to 0.90) for the decreased activity group.

84 ivity group; and 0.93 (0.59 to 1.42) for the decreased activity group.

85 nd Arg120 mutations resulted in enzymes with decreased activity highlighting the importance of these

86 y increased activity in 60 brain regions and decreased activity in 9; in contrast, Nalox-Nalb activat

87 (TLR2 Asp-730) in Region II also resulted in decreased activity in agreement with our model, providin

88 n with the preceding pacing phase except for decreased activity in auditory-related regions due to th

89 ing cues, PG subjects demonstrate relatively decreased activity in brain regions implicated in impuls

90 associated with altered face processing and decreased activity in brain regions involved in face pro

91 e reaction analyses revealed a significantly decreased activity in cells derived from adenocarcinomas

92 Sp4 at the mRNA and protein levels and also decreased activity in cells transfected with constructs

93 ns exhibiting at least twofold-increased or -decreased activity in comparison to the wild type were f

94 sulted in increased brainstem metabolism and decreased activity in cortical structures including bila

95 Relatively decreased activity in corticostriatal neurocircuitry dur

96 Decreased activity in DLS neurons may reflect a common n

97 scenarios: PG subjects displayed relatively decreased activity in frontal and orbitofrontal cortex,

98 activity is essential in all organisms, and decreased activity in humans leads to the autosomal rece

99 tase 2A and MAPK phosphatase-3) demonstrated decreased activity in hyperoxia-exposed cells.

100 However, there was a decreased activity in injured rats to 62.1+/-8.2% (p</=0

101 Also area 7 only displayed decreased activity in its LPZ in the first weeks postles

102 emporal gyri, and posterior cerebellum, with decreased activity in occipital and superior temporal re

103 e different from a previous study that found decreased activity in pain-sensitive regions such as the

104 We observed decreased activity in photoreceptors in response to flas

105 m-CPP also decreased activity in primary sensory neurons in the cra

106 cortex; however, the latter structure shows decreased activity in rapid eye movement (REM) sleep.

107 ventrolateral prefrontal cortices, and (ii) decreased activity in regions previously associated with

108 iddle temporal and inferior frontal gyri and decreased activity in right inferotemporal cortical area

109 lt mode' regions reported previously to show decreased activity in seizures and in normal behavioural

110 Decreased activity in the ACC/medial prefrontal cortex (

111 function to the healthy hemisphere and/or to decreased activity in the affected hemisphere.

112 uring the decision phase was associated with decreased activity in the anterior insula; activation in

113 ganglia, brainstem and thalamus), along with decreased activity in the association cortex may be cruc

114 Comorbid patients presented decreased activity in the cingulate gyrus, right PrCS an

115 Bcl-2 mutants that displayed increased or decreased activity in the conformational alteration assa

116 he flhDC::lacZ transcriptional fusion showed decreased activity in the fliA mutant compared with wild

117 f the egestion-promoting interneuron B20 and decreased activity in the ingestion-promoting interneuro

118 rontal and right cerebellar regions and with decreased activity in the left hippocampus and left cere

119 stimuli, pathological gamblers demonstrated decreased activity in the left ventromedial prefrontal c

120 While decreased activity in the medial prefrontal cortex (mPFC

121 aging studies performed in patients point to decreased activity in the mediodorsal thalamus (MD) and

122 iduals with high levels of HPA activity, and decreased activity in the motor cortex (M1) was selectiv

123 nse in the dorsomedial prefrontal cortex and decreased activity in the orbitofrontal cortex.

124 wild-type enzyme, the mutant showed 150-fold decreased activity in the physiological NADH-CH(2)-H(4)f

125 Further, daytime fatigue may reflect decreased activity in the prefrontal cortex resulting fr

126 OU2F and YY1 is significantly impaired, with decreased activity in the presence of the C- allele comp

127 Under placebo, the AS group showed decreased activity in the right amygdala, fusiform gyrus

128 s and the siblings, patients with OCD showed decreased activity in the right inferior parietal cortex

129 ed increased activity in auditory cortex and decreased activity in visual cortex and vice versa, refl

130 y a K342N mutation in p110beta, which led to decreased activity in vitro, decreased basal Akt and rib

131 To resolve whether such decreased activity is directly or indirectly mediated by

132 Thus, increased nAChR activity, like decreased activity, leads to enhanced extracellular DA r

133 frontotemporal dementia was associated with decreased activity levels compared to controls (P = 0.00

134 -reduction potentials than normal flavin and decreased activity levels with analogues exhibiting lowe

135 All infected mice lost weight and showed decreased activity levels.

136 In response to decreased activity, neurons make global compensatory inc

137 Here, we show that the decreased activity observed for the OE is caused by a de

138 The decreased activity observed in alpha5-SNP-expressing mic

139 These results suggest that the decreased activity observed in these mutants cannot be e

140 g recall relative to when recall failed, and decreased activity occurring for familiar relative to un

141 ated with DKK1, which is concurrent with the decreased activities of beta-catenin and of glucose-synt

142 While the decreased activities of both A22S and V108M COMT are ass

143 sting kidneys of rats on the 8.0% NaCl diet, decreased activities of both p38 MAPK and p42/44 MAPK, c

144 n muscle fibers, ERS induction significantly decreased activities of cathepsins D and B, increased le

145 es of LDH (194%), PK (90%), and HK (24%) and decreased activities of CS (15%) and GDH (34%).

146 rv1 mutant strain (erv1-1) had significantly decreased activities of cytosolic Fe-S enzymes.

147 Visual impairment, medication variables, decreased activities of daily living, and impaired cogni

148 They included decreased activities of Fe-S cluster-dependent enzymes,

149 n the absence of the YggX protein, and (iii) decreased activities of Fe-S proteins, including aconita

150 ISO caused Ser-9 phosphorylation and decreased activities of GSK3beta.

151 h ataxia (FRDA) fibroblasts, associated with decreased activities of ISC respiratory complexes.

152 Decreased activities of key tricarboxylic acid cycle (TC

153 es suggestive of decreased LA production and decreased activities of lipoamide-requiring enzymes.

154 Decreased activities of mitochondrial complexes I, II, a

155 ase-negative fibers, and biochemistry showed decreased activities of respiratory chain complexes cont

156 reased levels of ALT, AST and MDA along with decreased activities of SOD and CAT were significantly (

157 hy with abundant cytoplasmic lipid droplets, decreased activities of the mitochondrial respiratory ch

158 l-DOPA treatments also led to decreased activities of thioredoxin (Trx) and thioredoxi

159 vels of the saturated fatty acid 16:0 due to decreased activity of 3-ketoacyl-acyl carrier protein (A

160 ted with reduced BPH risk, which may reflect decreased activity of 5-alpha-reductase.

161 /or GSK3 activity or, alternatively, through decreased activity of a CRMP phosphatase.

162 Furthermore, the drug decreased activity of a reporter containing the -88/+54

163 h leads to decreased disulfide formation and decreased activity of a subgroup of disulfide-containing

164 ed levels of ThPP in their mitochondria, and decreased activity of acetolactate synthase, a ThPP-requ

165 med fibroblasts showed cell-cycle arrest and decreased activity of Akt kinase.

166 phage colony-stimulating factor and markedly decreased activity of aldehyde dehydrogenase; activity o

167 The finding of a marked decreased activity of alpha-galactosidase A in white blo

168 showed hypogalactosylation, consistent with decreased activity of another Mn-dependent enzyme, beta-

169 Here we show that decreased activity of ASS1 in cancers supports prolifera

170 ncompletely processed lamellar membranes and decreased activity of beta-glucocerebrosidase.

171 ation of increased noradrenaline release and decreased activity of both NOS per se and of process(es)

172 life-threatening rare disease caused by the decreased activity of C1-INH.

173 gulated EGFR signaling induced by c-Cbl-N480 decreased activity of Cdc42 and Rac1, resulting in inhib

174 ased expression of the cdk inhibitor p27 and decreased activity of cdk 2, cdk 4 and cdk 6.

175 m by which feeding high fat diets results in decreased activity of ChREBP in the liver.

176 ity staining method we have previously shown decreased activity of complex V (F(1)F(0)-ATPase) in mal

177 3.0; OVX, 178.0 +/- 20.5 AU; P < 0.001), and decreased activity of cortical MMP-9 (Intact, 3.8 +/- 0.

178 that sphingosine accumulation resulted in a decreased activity of COX, a rate-limiting enzyme of the

179 ion of Chk2, decreased levels of Cdc25A, and decreased activity of cyclin E-cyclin-dependent kinase 2

180 ted expression of p53 and p21(WAF1), and had decreased activity of cyclin-dependent kinase 2.

181 thus defining a mechanism that accounts for decreased activity of CYLD in the absence of p62.

182 on, removal of these polypeptides results in decreased activity of CytcO, but not of cyt. bc1 In the

183 hondrial oxidative metabolism, in particular decreased activity of cytochrome c oxidase, have been re

184 as its deletion in vitro and in vivo led to decreased activity of cytosolic, but not mitochondrial,

185 Basal Sost down-regulation follows decreased activity of ERalpha and increased activity of

186 increased expression of the Fur regulon, and decreased activity of Fe-S cluster proteins.

187 These findings suggest that the decreased activity of FKHRL1 and FKHR in prostate cancer

188 The decreased activity of GAD65 and increased levels of glut

189 Both increased and decreased activity of gamma-tubulin, the core microtubul

190 hermore, brains from cln3-knockout mice have decreased activity of glutamic acid decarboxylase as a r

191 ce oxidative stress in vitro resulted in the decreased activity of glutathione reductase and thioredo

192 gs reaffirmed that S-persulfidation leads to decreased activity of glyceraldehyde 3-phosphate dehydro

193 antly in naked mole-rat tissues owing to the decreased activity of HA-degrading enzymes and a unique

194 the increased expression of perilipin-2 and decreased activity of hormone-sensitive lipase (HSL) in

195 CREB and NF-kappaB transcription factors and decreased activity of IFN response factors (IRFs) in str

196 oforms, inhibitors of insulin signaling, and decreased activity of insulin signaling molecules Akt an

197 In contrast, vHPC inactivation decreased activity of interneurons in PL and increased P

198 AMPK activation leads to decreased activity of its downstream target, ribosomal p

199 ant association between mutant ropB alleles, decreased activity of its major regulatory target SpeB,

200 demonstrated that the PNH is mediated by the decreased activity of K(v)1-channels.

201 as attributable to increased acetylation and decreased activity of manganese superoxide dismutase (Mn

202 ast cancer cells in a manner associated with decreased activity of matrix metalloproteinase (MMP)-3 a

203 inhibitor of matrix metalloproteinase-1 with decreased activity of matrix metalloproteinase-9.

204 d CH4 release was mainly attributable to the decreased activity of methanogens along with the increas

205 Huntington's disease (HD) is associated with decreased activity of mitochondrial succinate dehydrogen

206 Despite an overall decreased activity of nearly 1000-fold relative to the E

207 oter-based bioinformatic analyses implicated decreased activity of NF-kappaB/Rel and GATA family tran

208 Decreased activity of osteoblasts (OBs) contributes to o

209 Both also had decreased activity of PDX1, which correlated with lower

210 The decreased activity of PeCsn without PeCBM32 on chitosan

211 The increased nitration and decreased activity of PGIS by CRP was reversed with pero

212 , at least in part via a mechanism involving decreased activity of phosphatidylinositol 3-kinase/AKT

213 Two knockdown alleles of NRAMP2 showed decreased activity of photosystem II and increased oxida

214 sphorylation of syndecan-4, displacement and decreased activity of PKCalpha, binding of alpha-actinin

215 olled feeding in sated mice is paralleled by decreased activity of POMC neurons.

216 yper-phosphorylation of BRD4 attributable to decreased activity of PP2A, identified here as a princip

217 We also demonstrate that the decreased activity of PrimPolY89D is associated with red

218 nes expressing mutant alpha-synuclein showed decreased activity of proteasomes without direct toxicit

219 Reduction of Hsp90 protein decreased activity of PS-ASOs with 5'-LNA or 5'-cEt wing

220 Finally, decreased activity of PTEN, an endogenous negative regul

221 iomyopathy, and was found to have profoundly decreased activity of respiratory chain complex I in mus

222 but it was 2.3-fold higher in a strain with decreased activity of RNase Y, a recently discovered RNa

223 Decreased activity of sel-12, a C. elegans homologue of

224 While mutations in apbE cause decreased activity of several iron-sulfur enzymes in viv

225 Decreased activity of SIRT1 was validated using genomic

226 Mutation of the Myb-binding site decreased activity of SP-A promoter constructs in MLE-15

227 her, treatment with triptolide resulted in a decreased activity of Sp1 and NF-kB the two major oncoge

228 xin2, Cyclin D1, and Cyclin D2 and exhibited decreased activity of the Batgal Wnt/beta-catenin report

229 3HIA-carnitine) increases in response to the decreased activity of the biotin-dependent enzyme methyl

230 aleric acid (3-HIA), which probably reflects decreased activity of the biotin-dependent enzyme methyl

231 d relationship between the IDH1 mutation and decreased activity of the branched-chain amino acid tran

232 phenotypes associated with a prsA2 mutant is decreased activity of the broad-range phospholipase C (P

233 atin remodeling complex CBP/p300, as well as decreased activity of the CBP/p300 inhibitor p38, result

234 der such copper limitation, tumors displayed decreased activity of the copper-binding mitochondrial e

235 The significantly decreased activity of the Cys-218 and Cys-227 variants i

236 dic extracellular pH in these tumors and the decreased activity of the enzyme at low pH.

237 profiles, deletion of the CBM56 from BH0236 decreased activity of the enzyme on the insoluble beta-1

238 ne, and have increased levels of choline and decreased activity of the enzyme sinapoylglucose:choline

239 residue in the active site, and acetylation decreased activity of the enzymes by >70%.

240 There is now evidence for both increased and decreased activity of the enzymes controlling the methyl

241 et of rapamycin (mTOR)-p70S6K signalling and decreased activity of the forkhead family member FOXO3a.

242 Parkinson disease (PD) is associated with a decreased activity of the glucocerebrosidase (GCase) enz

243 NKX6.1-mediated activation and substantially decreased activity of the HNF1alpha promoter in beta cel

244 c-Jun dose dependently decreased activity of the human ITPR2 promoter.

245 nhibitors of soluble guanylyl cyclase or PKG decreased activity of the I425V mutant, but not wild typ

246 sis (Arabidopsis thaliana) which, due to the decreased activity of the lycopene-beta-cyclase, shows a

247 also show impaired lysosomal proteolysis and decreased activity of the lysosomal enzyme cathepsin D.

248 sed expression of alpha-Syn and consequently decreased activity of the lysosomal enzyme glucocerebros

249 ion in the expression of lysosomal genes and decreased activity of the lysosomal enzyme, cathepsin D.

250 Parkinson disease is associated with decreased activity of the mitochondrial electron transpo

251 in the double vnfR1 vnfR2 mutant resulted in decreased activity of the Mo-nitrogenase.

252 Reporter gene experiments showed that NO. decreased activity of the PLK1 proximal promoter, an eff

253 nstrated that the effects of PGE(2) involved decreased activity of the prosurvival molecule Akt.

254 ncreased plasma membrane binding of RhoA and decreased activity of the Rho/Ras-regulated p21(WAF1/CIP

255 related neurons during early performance and decreased activity of the same neurons during overtraini

256 Ca channel (ryanodine receptor, RyR) and/or decreased activity of the SR Ca ATPase (SERCA).

257 a, whereas a small interfering RNA for PIAS1 decreased activity of these promoters, as well as endoge

258 eas myocardin short interfering RNA markedly decreased activity of these promoters.

259 Cells lacking PDK-1 show decreased activity of these protein kinases, including p

260 plex subunit 9 of respiratory complex I, and decreased activity of this complex as well as of complex

261 residue, Lys82, might be responsible for the decreased activity of this variant.

262 9 dominant-negative mutant (Ubc9-DN) display decreased activity of topo I, these cells are more sensi

263 defects in colitis are discussed, including decreased activity of transport proteins such as CFTR, b

264 thesis; increased phospholipid synthesis; or decreased activity of triglyceride-synthesizing enzymes

265 ion were due to stabilization resulting from decreased activity of TTP, the tristetraprolin RNA-bindi

266 NA knockdown of IscA1 in HeLa cells leads to decreased activity of two mitochondrial iron-sulfur enzy

267 Decreased activity of type I 5'-deiodinase (DIO1), which

268 The syndrome is due in part to decreased activity of type I iodothyronine 5'-deiodinase

269 h the A229V and L230C mutations specifically decreased activity on BMCC, suggesting that BMCC hydroly

270 ut affecting its internalization, leading to decreased activity on the cell surface.

271 ctivity, but a 6-bp change in the -35 region decreased activity only about twofold.

272 erythroleukemia cells, mutation of each site decreased activity; overexpression of RUNX1 up-regulated

273 HPA axis resulting in increased rather than decreased activity, presumably via alterations in centra

274 amples from the same patients (n = 4) showed decreased activity prior to and at the time of cerebral

275 It is not clear how decreased activity quantitatively affects energy balance

276 Secreted mutants have decreased activities relative to WT FVIII.

277 Older women with decreased activity rhythms had a higher likelihood of de

278 , Y155E, and K159A) or enzyme with a greatly decreased activity (S142A).

279 idening after exocytosis; a Dyn1 mutant with decreased activity slowed fusion pore widening by stabil

280 357D) but not the phosphodeficient mutations decreased activity, suggesting that phosphorylation of t

281 modeling hypomorphic missense mutations had decreased activity that correlated with disease severity

282 Mutation of His 115 to Asn 115 resulted in decreased activity to 2.9% of wild-type, with retention

283 Titration of ethidium bromide into the assay decreased activity to a basal level of approximately 18%

284 ency to inhibit tubulin polymerization but a decreased activity to inhibit Hsp27 chaperone function,

285 the oxyimino-cephalosporin, ceftazidime, and decreased activity toward all other beta-lactams tested.

286 ing mutation of meprin betaK185Y resulted in decreased activity toward gastrin.

287 Ion-milled areas also showed significantly decreased activity toward photo-oxidations, providing ev

288 sed PKD1 activation loop phosphorylation and decreased activity toward SSH1L.

289 Decreased activity was more prominent anteriorly and on

290 ted (i.e., ADAM10, 12, and 17) significantly decreased activity when the TNFalpha-derived sequence wa

291 Subclass switching the IgG4 mAb to IgG1 decreased activity, whereas switching to IgG2 markedly i

292 Oxidized PRMT1 displays decreased activity, which can be rescued by reduction.

293 mutations in PTB binding sites show markedly decreased activity, while cells that stably overexpress

294 racts from kat2 seedlings have significantly decreased activity with aceto-acetyl CoA, and KAT2 appea

295 ntal brain region in each contrast exhibited decreased activity with age: left inferior frontal gyrus

296 The DeltaGly-143 protein had moderately decreased activity with cytochrome P450 and cytochrome c

297 CPr14 shows decreased activity with most PTS permeases relative to H

298 ) and Fe(2+) under anaerobic conditions, but decreased activity with Zn(2+).

299 ignificant dose response relating VF loss to decreased activity, with each 5 dB decrement in the bett

300 , unmedicated individuals with BD II/NOS had decreased activity within the DS (but not VS).