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1 phenotype characterized by gait changes and decreased activity.
2 dition of phosphatidylinositol significantly decreased activity.
3 nge, while mock-immunized hamsters displayed decreased activity.
4 herence, while disruption of Hpt resulted in decreased activity.
5 increased NREM time, decreased REM time, and decreased activity.
6 oped in the bottle-fed group, accompanied by decreased activity.
7 , direct attachment of an amino group led to decreased activity.
8 e obesity is associated with hyperphagia and decreased activity.
9 sulfoxides or sulfones leads to compounds of decreased activity.
10 ha during increased activity and beta during decreased activity.
11 up to the lumazine by one carbon resulted in decreased activity.
12 e to intrinsic or extrinsic factors leads to decreased activity.
13 Its replacement by an amino group led to decreased activity.
14 quitination and protein turnover, as well as decreased activity.
15 ilarly, whereas a nonphosphorylatable mutant decreased activity.
16 eased Rc3h1 promoter activity, whereas IKZF2 decreased activity.
17 tives with increased steric volume exhibited decreased activities.
18 ut the double cysteine mutant had a modestly decreased activity (1.75 +/- 0.14 micromol of NO min(-1)
19 = mildly decreased activity, 2 = moderately decreased activity, 1 = severely decreased activity, and
20 ng criteria: 4 = normal activity, 3 = mildly decreased activity, 2 = moderately decreased activity, 1
23 ated nNOS with H2S under turnover conditions decreased activity after dilution by approximately 70%,
24 lity to generate long-term immune memory and decreased activities against tumour-cell subpopulations
25 (10.5% non-WT), whereas posaconazole showed decreased activity against C. albicans (4.4%) and Candid
29 onset SMA characterized by muscle weakness, decreased activity and an alteration of the muscle fiber
30 tion of the most C-terminal of these domains decreased activity and caused enzyme aggregation and ins
31 consistent micrographia was associated with decreased activity and connectivity in the basal ganglia
32 e effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key c
34 ynthesizing enzyme NAPE-phospholipase D, and decreased activity and expression of the OEAdegrading en
35 an FA-HFD males, and all males on HFD showed decreased activity and increased anxiety, whereas female
39 ased activity of the lipid phosphatase PTEN, decreased activity and phosphorylation (Ser(473)) of Akt
40 chronic exposure of endothelial cells to NO decreased activity and protein levels of complexes I, II
41 creased proximal phosphate reabsorption, and decreased activity and protein of the principal renal ph
42 of nighttime quiescence, Cassiopea exhibited decreased activity and reduced responsiveness to a senso
43 ad potent antiviral activity, in contrast to decreased activity and selectivity observed for 2'-deoxy
46 rom Methanocaldococcus jannaschii showed 76% decreased activity and the MjE102Q mutation completely a
47 ls, mammalian target of rapamycin (mTOR) had decreased activity and was dissociated from lysosomes; t
50 lacking the basic nitrogen (3i and 6d), show decreased activity at all monoamine transporters, though
51 ubstitution resulted in several analogs with decreased activity at alpha3(*) versus alpha6(*) nAChRs
52 ariably followed by a DC voltage shift and a decreased activity at both low (30-57 Hz)- and high (63-
55 subjects, unmedicated MDD subjects exhibited decreased activity bilaterally in the dorsal mid-insula
57 ormer toward template RNA and results in its decreased activity both in de novo RNA synthesis and in
58 eduction of the acetylene to an ethyl moiety decreased activity, both in functional and binding assay
59 sulfate (GSSG) ratio was associated with the decreased activity, but not protein content, of glucose
60 ) forms disulfide-bonded dimers that exhibit decreased activity, but retain the ability to bind asial
61 s, whereas deletion of part of the stem-loop decreased activity by 100-fold, and deletion of the dist
62 ution of a Ser for either Cys-186 or Cys-406 decreased activity by 20-fold and abrogated the response
65 re to the cocaine-conditioned context showed decreased activity compared with the vehicle control gro
68 protein multimerization, exhibited severely decreased activity, demonstrating that E4-ORF3 self-asse
70 we found that the L1CAM mutation selectively decreased activity-dependent Na(+)-currents, altered neu
72 we defined PCC and vACC regions that showed decreased activity during a cognitive (working memory) t
76 linical symptoms such as coughing, sneezing, decreased activity, fever, and labored breathing in chal
77 d in the formation of disulfide bonds and in decreased activities for the wild-type and C56S/C242S en
80 nd Arg120 mutations resulted in enzymes with decreased activity highlighting the importance of these
81 y increased activity in 60 brain regions and decreased activity in 9; in contrast, Nalox-Nalb activat
82 (TLR2 Asp-730) in Region II also resulted in decreased activity in agreement with our model, providin
83 he original source of information as well as decreased activity in auditory regions associated with t
84 n with the preceding pacing phase except for decreased activity in auditory-related regions due to th
85 ing cues, PG subjects demonstrate relatively decreased activity in brain regions implicated in impuls
86 associated with altered face processing and decreased activity in brain regions involved in face pro
88 e reaction analyses revealed a significantly decreased activity in cells derived from adenocarcinomas
89 Sp4 at the mRNA and protein levels and also decreased activity in cells transfected with constructs
90 ns exhibiting at least twofold-increased or -decreased activity in comparison to the wild type were f
91 sulted in increased brainstem metabolism and decreased activity in cortical structures including bila
94 compared with abundance, a scarcity mindset decreased activity in dorsolateral prefrontal cortex, an
95 scenarios: PG subjects displayed relatively decreased activity in frontal and orbitofrontal cortex,
99 auses reduced infant-directed aggression and decreased activity in MeA neurons during male-infant int
100 emporal gyri, and posterior cerebellum, with decreased activity in occipital and superior temporal re
101 e different from a previous study that found decreased activity in pain-sensitive regions such as the
105 cortex; however, the latter structure shows decreased activity in rapid eye movement (REM) sleep.
106 ventrolateral prefrontal cortices, and (ii) decreased activity in regions previously associated with
107 iddle temporal and inferior frontal gyri and decreased activity in right inferotemporal cortical area
108 lt mode' regions reported previously to show decreased activity in seizures and in normal behavioural
112 uring the decision phase was associated with decreased activity in the anterior insula; activation in
113 ganglia, brainstem and thalamus), along with decreased activity in the association cortex may be cruc
115 Bcl-2 mutants that displayed increased or decreased activity in the conformational alteration assa
116 ases in activity in medial frontal lobe with decreased activity in the dorsolateral prefrontal cortex
117 he flhDC::lacZ transcriptional fusion showed decreased activity in the fliA mutant compared with wild
118 f the egestion-promoting interneuron B20 and decreased activity in the ingestion-promoting interneuro
119 stimuli, pathological gamblers demonstrated decreased activity in the left ventromedial prefrontal c
121 aging studies performed in patients point to decreased activity in the mediodorsal thalamus (MD) and
122 iduals with high levels of HPA activity, and decreased activity in the motor cortex (M1) was selectiv
125 OU2F and YY1 is significantly impaired, with decreased activity in the presence of the C- allele comp
127 s and the siblings, patients with OCD showed decreased activity in the right inferior parietal cortex
128 ed increased activity in auditory cortex and decreased activity in visual cortex and vice versa, refl
129 y a K342N mutation in p110beta, which led to decreased activity in vitro, decreased basal Akt and rib
133 frontotemporal dementia was associated with decreased activity levels compared to controls (P = 0.00
139 g recall relative to when recall failed, and decreased activity occurring for familiar relative to un
140 ated with DKK1, which is concurrent with the decreased activities of beta-catenin and of glucose-synt
142 sting kidneys of rats on the 8.0% NaCl diet, decreased activities of both p38 MAPK and p42/44 MAPK, c
143 n muscle fibers, ERS induction significantly decreased activities of cathepsins D and B, increased le
146 Visual impairment, medication variables, decreased activities of daily living, and impaired cogni
148 n the absence of the YggX protein, and (iii) decreased activities of Fe-S proteins, including aconita
151 es suggestive of decreased LA production and decreased activities of lipoamide-requiring enzymes.
154 ase-negative fibers, and biochemistry showed decreased activities of respiratory chain complexes cont
155 reased levels of ALT, AST and MDA along with decreased activities of SOD and CAT were significantly (
156 hy with abundant cytoplasmic lipid droplets, decreased activities of the mitochondrial respiratory ch
159 vels of the saturated fatty acid 16:0 due to decreased activity of 3-ketoacyl-acyl carrier protein (A
163 h leads to decreased disulfide formation and decreased activity of a subgroup of disulfide-containing
164 ed levels of ThPP in their mitochondria, and decreased activity of acetolactate synthase, a ThPP-requ
166 phage colony-stimulating factor and markedly decreased activity of aldehyde dehydrogenase; activity o
167 showed hypogalactosylation, consistent with decreased activity of another Mn-dependent enzyme, beta-
170 ation of increased noradrenaline release and decreased activity of both NOS per se and of process(es)
172 gulated EGFR signaling induced by c-Cbl-N480 decreased activity of Cdc42 and Rac1, resulting in inhib
173 ity staining method we have previously shown decreased activity of complex V (F(1)F(0)-ATPase) in mal
175 3.0; OVX, 178.0 +/- 20.5 AU; P < 0.001), and decreased activity of cortical MMP-9 (Intact, 3.8 +/- 0.
176 that sphingosine accumulation resulted in a decreased activity of COX, a rate-limiting enzyme of the
177 ion of Chk2, decreased levels of Cdc25A, and decreased activity of cyclin E-cyclin-dependent kinase 2
179 e, we identified synthetic lethality between decreased activity of cyclin-dependent kinases 4 and 6 (
181 on, removal of these polypeptides results in decreased activity of CytcO, but not of cyt. bc1 In the
182 hondrial oxidative metabolism, in particular decreased activity of cytochrome c oxidase, have been re
183 as its deletion in vitro and in vivo led to decreased activity of cytosolic, but not mitochondrial,
189 hermore, brains from cln3-knockout mice have decreased activity of glutamic acid decarboxylase as a r
190 ce oxidative stress in vitro resulted in the decreased activity of glutathione reductase and thioredo
191 gs reaffirmed that S-persulfidation leads to decreased activity of glyceraldehyde 3-phosphate dehydro
193 antly in naked mole-rat tissues owing to the decreased activity of HA-degrading enzymes and a unique
194 the increased expression of perilipin-2 and decreased activity of hormone-sensitive lipase (HSL) in
195 Diabetic myocardium also had significantly decreased activity of hydroxyacyl-CoA dehydrogenase (HAD
196 CREB and NF-kappaB transcription factors and decreased activity of IFN response factors (IRFs) in str
197 oforms, inhibitors of insulin signaling, and decreased activity of insulin signaling molecules Akt an
200 ant association between mutant ropB alleles, decreased activity of its major regulatory target SpeB,
202 as attributable to increased acetylation and decreased activity of manganese superoxide dismutase (Mn
203 ast cancer cells in a manner associated with decreased activity of matrix metalloproteinase (MMP)-3 a
205 d CH4 release was mainly attributable to the decreased activity of methanogens along with the increas
206 e morphological changes were associated with decreased activity of mitochondrial complexes I, III and
207 Huntington's disease (HD) is associated with decreased activity of mitochondrial succinate dehydrogen
208 oter-based bioinformatic analyses implicated decreased activity of NF-kappaB/Rel and GATA family tran
213 , at least in part via a mechanism involving decreased activity of phosphatidylinositol 3-kinase/AKT
215 sphorylation of syndecan-4, displacement and decreased activity of PKCalpha, binding of alpha-actinin
217 yper-phosphorylation of BRD4 attributable to decreased activity of PP2A, identified here as a princip
221 iomyopathy, and was found to have profoundly decreased activity of respiratory chain complex I in mus
223 but it was 2.3-fold higher in a strain with decreased activity of RNase Y, a recently discovered RNa
227 her, treatment with triptolide resulted in a decreased activity of Sp1 and NF-kB the two major oncoge
230 xin2, Cyclin D1, and Cyclin D2 and exhibited decreased activity of the Batgal Wnt/beta-catenin report
231 3HIA-carnitine) increases in response to the decreased activity of the biotin-dependent enzyme methyl
232 aleric acid (3-HIA), which probably reflects decreased activity of the biotin-dependent enzyme methyl
233 d relationship between the IDH1 mutation and decreased activity of the branched-chain amino acid tran
234 phenotypes associated with a prsA2 mutant is decreased activity of the broad-range phospholipase C (P
235 atin remodeling complex CBP/p300, as well as decreased activity of the CBP/p300 inhibitor p38, result
236 der such copper limitation, tumors displayed decreased activity of the copper-binding mitochondrial e
238 profiles, deletion of the CBM56 from BH0236 decreased activity of the enzyme on the insoluble beta-1
240 There is now evidence for both increased and decreased activity of the enzymes controlling the methyl
241 et of rapamycin (mTOR)-p70S6K signalling and decreased activity of the forkhead family member FOXO3a.
242 Parkinson disease (PD) is associated with a decreased activity of the glucocerebrosidase (GCase) enz
243 NKX6.1-mediated activation and substantially decreased activity of the HNF1alpha promoter in beta cel
245 nhibitors of soluble guanylyl cyclase or PKG decreased activity of the I425V mutant, but not wild typ
246 sis (Arabidopsis thaliana) which, due to the decreased activity of the lycopene-beta-cyclase, shows a
247 also show impaired lysosomal proteolysis and decreased activity of the lysosomal enzyme cathepsin D.
248 sed expression of alpha-Syn and consequently decreased activity of the lysosomal enzyme glucocerebros
249 ion in the expression of lysosomal genes and decreased activity of the lysosomal enzyme, cathepsin D.
252 Reporter gene experiments showed that NO. decreased activity of the PLK1 proximal promoter, an eff
253 nstrated that the effects of PGE(2) involved decreased activity of the prosurvival molecule Akt.
254 ncreased plasma membrane binding of RhoA and decreased activity of the Rho/Ras-regulated p21(WAF1/CIP
255 related neurons during early performance and decreased activity of the same neurons during overtraini
257 a, whereas a small interfering RNA for PIAS1 decreased activity of these promoters, as well as endoge
260 plex subunit 9 of respiratory complex I, and decreased activity of this complex as well as of complex
262 9 dominant-negative mutant (Ubc9-DN) display decreased activity of topo I, these cells are more sensi
263 defects in colitis are discussed, including decreased activity of transport proteins such as CFTR, b
264 thesis; increased phospholipid synthesis; or decreased activity of triglyceride-synthesizing enzymes
265 ion were due to stabilization resulting from decreased activity of TTP, the tristetraprolin RNA-bindi
266 NA knockdown of IscA1 in HeLa cells leads to decreased activity of two mitochondrial iron-sulfur enzy
270 erythroleukemia cells, mutation of each site decreased activity; overexpression of RUNX1 up-regulated
271 heterogeneous populations with substantially decreased activity, precluding their successful applicat
272 HPA axis resulting in increased rather than decreased activity, presumably via alterations in centra
273 amples from the same patients (n = 4) showed decreased activity prior to and at the time of cerebral
277 ling present normal turning behavior despite decreased activity, restoring Dop1R1 level in R2/R4m-spe
280 idening after exocytosis; a Dyn1 mutant with decreased activity slowed fusion pore widening by stabil
281 357D) but not the phosphodeficient mutations decreased activity, suggesting that phosphorylation of t
282 modeling hypomorphic missense mutations had decreased activity that correlated with disease severity
283 Titration of ethidium bromide into the assay decreased activity to a basal level of approximately 18%
284 ency to inhibit tubulin polymerization but a decreased activity to inhibit Hsp27 chaperone function,
285 the oxyimino-cephalosporin, ceftazidime, and decreased activity toward all other beta-lactams tested.
287 Ion-milled areas also showed significantly decreased activity toward photo-oxidations, providing ev
291 reporter, while the original study reported decreased activity when SERINC1, VAPA, and CNOT6L were d
292 ted (i.e., ADAM10, 12, and 17) significantly decreased activity when the TNFalpha-derived sequence wa
293 Subclass switching the IgG4 mAb to IgG1 decreased activity, whereas switching to IgG2 markedly i
295 ntal brain region in each contrast exhibited decreased activity with age: left inferior frontal gyrus
296 The DeltaGly-143 protein had moderately decreased activity with cytochrome P450 and cytochrome c
299 ignificant dose response relating VF loss to decreased activity, with each 5 dB decrement in the bett