ライフサイエンスコーパス: dedifferentiate

1 erentiated murine myotubes can be induced to dedifferentiate.

2 d enriched among cells that were injured and dedifferentiated.

3 s, and these SMCs are hyperproliferative and dedifferentiated.

4 1 isoform A3 (ALDH(+)) as beta cells become dedifferentiated.

5 Plant cells rapidly dedifferentiated.

6 resented with well-differentiated, 143 (18%) dedifferentiated, 144 (18%) myxoid, 81 (10%) round cell,

7 quently amplified in G2 (15%), G3 (20%), and dedifferentiated (21%) chondrosarcomas.

8 constructed tissue microarrays containing 42 dedifferentiated, 23 clear cell, and 23 mesenchymal chon

9 e 1 (18%), grade 2 (31%), grade 3 (80%), and dedifferentiated (29%) chondrosarcomas, but was not foun

10 nted with well-differentiated, 65 (37%) with dedifferentiated, 9 (5%) with myxoid, and 4 (2%) with ro

11 ancreatic injury, elimination of Numb causes dedifferentiated acinar cells to undergo apoptosis, and

12 eta-cells through cell-cell interaction with dedifferentiating acinar cells and a cell autonomous pro

13 Chondrocytes in monolayer become dedifferentiated, acquiring a fibroblast-like appearance

14 growth environments that were sufficient to dedifferentiate aged human MSCs to an early mesendoderm-

15 The proliferating Muller glia dedifferentiate and a subset of these cells differentiat

16 cancer progenitor cells have the capacity to dedifferentiate and acquire a stem-like phenotype in res

17 non-stem cancer cells have the potential to dedifferentiate and acquire stem cell properties as a di

18 uggested that alpha1T-expressing Muller glia dedifferentiate and become multipotent in response to in

19 Upon gene inactivation, these progeny can dedifferentiate and generate malignant tumors.

20 t that in older adults, meniscal cells might dedifferentiate and initiate a proliferative phenotype.

21 ongly suggest alpha1T-expressing Muller glia dedifferentiate and mediate regeneration of the injured

22 found that hypoxia induces cardiomyocytes to dedifferentiate and proliferate during heart regeneratio

23 In the damaged zebrafish retina, Muller glia dedifferentiate and proliferate to generate neuronal pro

24 n injury, surviving tubular epithelial cells dedifferentiate and proliferate, eventually replacing th

25 s) are highly plastic cells that are able to dedifferentiate and re-enter the cell cycle.

26 differentiated myelinating Schwann cell can dedifferentiate and regain the potential to proliferate.

27 tinal smooth muscle cells have been shown to dedifferentiate and reinitiate their myogenic program in

28 lls of the dorsal, but not the ventral, iris dedifferentiate and then differentiate to form a new len

29 state of differentiation because SCs rapidly dedifferentiated and became competent to resume prolifer

30 or progenitor cells or from cells that have dedifferentiated and become proliferative.

31 Claudin-3-/- mice revealed dedifferentiated and leaky colonic epithelium, and devel

32 p of tumors in Arf(-/-) animals presented as dedifferentiated and metastatic, with many characteristi

33 , reduces invasion, and induces apoptosis in dedifferentiated and myxoid/round cell liposarcoma cell

34 olecule up-regulated in the cells, which are dedifferentiated and undergoing replication.

35 ll to adapt to the loss of adjacent cells by dedifferentiating and proliferating.

36 opurine), GCP expand, regenerate cell walls, dedifferentiate, and divide.

37 ylaminopurine), they reenter the cell cycle, dedifferentiate, and divide.

38 tumorigenic, that they are stable and do not dedifferentiate, and that they do not elicit immune resp

39 Sprouting venous endothelial cells dedifferentiate as they migrate over and invade the myoc

40 as quickly down-regulated and disappeared in dedifferentiated ASMC in culture.

41 In this study, we confirmed that transformed dedifferentiated astrocytes and neurons acquired a stem/

42 pmentally stalled neural progenitors or from dedifferentiated astrocytes?

43 Their acinar cells do not dedifferentiate at climax, nor do they down-regulate exo

44 GCPs dedifferentiating at 32 degrees C require both 1-napthal

45 o pathway signaling in vivo is sufficient to dedifferentiate, at very high efficiencies, adult hepato

46 ssing five subtypes, (a) well-differentiated/dedifferentiated, (b) myxoid/round cell, and (c) pleomor

47 mal apical-basal cortical polarity, they can dedifferentiate back into a neuroblast state, functional

48 Instead, they dedifferentiate back into mitotically cycling germ cells

49 ors, which contain cysts that break down and dedifferentiate back to single, mitotically active cells

50 e microenvironment, transit-amplifying cells dedifferentiate, becoming functional stem cells during t

51 Dedifferentiated beta cells reverted to progenitor-like

52 At an early stage, melanoma cells showed a dedifferentiated c-Jun(high)/MITF(low) phenotype, possib

53 lial cell preservation and conversion into a dedifferentiated cancer stem cell-like phenotype depends

54 t encompasses well-differentiated as well as dedifferentiated cancer types.

55 could be detected in similar assays with the dedifferentiated cell line HepG2.1 or the nonhepatic cel

56 val may be manifested by the production of a dedifferentiated cell with broader potential and that th

57 eration, we find no evidence to suggest that dedifferentiated cells acquire a ductal fate during this

58 , the proliferation and the migration of the dedifferentiated cells are dependent on Hh signaling.

59 transcription factors and that diseased and dedifferentiated cells can be returned to normal functio

60 transition, and exogenous PHD2 expression in dedifferentiated cells can restore an epithelial phenoty

61 and three IR-resistant clones isolated from dedifferentiated cells have acquired the ability to prol

62 RNAi-mediated knockdown of Oct4 in dedifferentiated cells led to diminished CSC phenotypes.

63 n organized structure of lineage restricted, dedifferentiated cells that cooperate to regenerate the

64 Dedifferentiated cells were morphologically indistinguis

65 lular matrix, and proliferation of partially dedifferentiated cells, evidence strongly supports the l

66 We characterize these dedifferentiating cells using several lineage-tracing st

67 e can restore chondrocyte gene expression in dedifferentiated chondrocytes grown on plastic.

68 Subsequent culture of the dedifferentiated chondrocytes in 3-dimensional alginate

69 Culture of dedifferentiated chondrocytes in alginate gel induces a

70 as 2-3-fold greater in nuclear extracts from dedifferentiated chondrocytes than in nuclear extracts f

71 in complex formed with nuclear extracts from dedifferentiated chondrocytes were 2-3-fold greater than

72 binding activity between differentiated and dedifferentiated chondrocytes.

73 ition with the BH-3 mimetic ABT-737 rendered dedifferentiated chondrosarcoma cell lines sensitive to

74 The mesenchymal, clear cell, and dedifferentiated chondrosarcoma subtypes are extremely r

75 comas, one pleomorphic rhabdomyosarcoma, one dedifferentiated chondrosarcoma, and one malignant perip

76 a survivors; the benefit of chemotherapy for dedifferentiated chondrosarcomas remains questionable; a

77 lanted from the Myh11(R247C/R247C) mice were dedifferentiated compared with wild-type SMCs based on i

78 d TGF-beta down-regulated GKLF expression in dedifferentiated cultured SMCs.

79 d decrease during desiccation, when plastids dedifferentiate/degenerate.

80 adipose tissue and well differentiated from dedifferentiated disease.

81 Human chondrocytes that otherwise rapidly dedifferentiate during in vitro culture also formed nodu

82 Insulin-producing beta cells become dedifferentiated during diabetes progression.

83 ouple of decades that it will be possible to dedifferentiate dysfunctional somatic cells in vivo to a

84 Conversion of SECs to a capillarized, dedifferentiated endothelium was confirmed at the cellul

85 By single-cell analysis of dedifferentiating enterocytes, we observed the generatio

86 lia promotes BMP7 signaling in repopulating, dedifferentiated epithelia.

87 KC and KCR8-16 mice developed dedifferentiated exocrine pancreata within 2 months of a

88 liferation were seen in conjunction with the dedifferentiated expression of cytokeratins 1, 10 and 5,

89 hat the answer lies in the need for cells to dedifferentiate first, and that what makes them dediffer

90 deleted in adult mice, Schwann cells readily dedifferentiate following peripheral nerve injury and be

91 Human SMCs are first dedifferentiated for 4 days to achieve a vascular progen

92 uggested that cells near the amputation site dedifferentiate forming multipotent progenitors that pop

93 Tumors derived from dedifferentiated germ cells, however, respond to the pro

94 in germline stem cell overproliferation and dedifferentiated germline stem cells.

95 undergoes pX-dependent transformation and a dedifferentiated hepatocyte (AML12) 4pX-1 cell line that

96 addition of hydrated matrix preparations to dedifferentiated hepatocytes.

97 or the survival of HBV variants in gradually dedifferentiating hepatocytes and thus helps prolong vir

98 rs by transient-transfection analysis in the dedifferentiated hepatoma cell line, HepG2.1.

99 plastic tissue culture flasks as monolayers (dedifferentiated HFC cultures).

100 ferentiation that was also down-regulated in dedifferentiated hfRPE cells.

101 he RPE, were significantly down-regulated in dedifferentiated hfRPE cells.

102 ted primary human fetal RPE (hfRPE) cells to dedifferentiated hfRPE cells.

103 8 mm), node negative in 93.4% of cases, and dedifferentiated (high-grade cancer) in 41.7% of cases a

104 Dedifferentiated histologic subtype and the need for con

105 Risk of recurrence is high for patients with dedifferentiated histology or retroperitoneal location.

106 The exocrine-enriched cells rapidly dedifferentiated in culture and grew as a mesenchymal mo

107 decidual cells from patients with sPE, which dedifferentiated in vitro, failed to redecidualize in cu

108 etic marks, and the mature B cells partially dedifferentiated, induced RAG-1 and -2 along with certai

109 to maintain VSMC quiescence and reverse the dedifferentiating influence of PDGF is mediated via the

110 ence, there is no apparent requirement for a dedifferentiated intermediate during the transdifferenti

111 tially dispensable but becomes essential for dedifferentiated intermediates to transit to ground stat

112 city of bryophytes, the ability of a cell to dedifferentiate into a meristematic state (analogous to

113 hepatocytes in culture have the capacity to dedifferentiate into a population of adult liver progeni

114 that adult mouse cardiomyocytes were able to dedifferentiate into cardiac progenitor-like cells (CPCs

115 t adult beta cells retain plasticity and can dedifferentiate into embryonic fates or adopt alternate

116 hacrylate), and from chondrocytes induced to dedifferentiate into fibroblast-like cells by passage in

117 (via a sequence of genetic alterations), to dedifferentiate into hepatocyte precursor cells (which t

118 to induce terminally differentiated cells to dedifferentiate into multipotent proliferative cells wit

119 nd Neurog1+ specified neuronal precursors to dedifferentiate into multipotent stem/progenitor cells t

120 expected plasticity of mature hepatocytes to dedifferentiate into progenitor cells in culture, and th

121 a subset of Muller cells to proliferate and dedifferentiate into RPCs.

122 This capacity of committed cells to dedifferentiate into stem cells may have a more general

123 y enlarged, disorganized, and in some cases, dedifferentiated into a callusoid mass.

124 strated that the luminal secretory cells had dedifferentiated into basal stem cells.

125 r hepatocyte loss, BECs proliferated as they dedifferentiated into hepatoblast-like cells; they subse

126 Single secretory cells clonally dedifferentiated into multipotent stem cells when they w

127 glia (MG) that respond to retinal injury by dedifferentiating into a cycling population of retinal p

128 departs from that assumption, spontaneously dedifferentiating into stem-like cells.

129 pe, we engineered MDA-MB-231 cells, a highly dedifferentiated, invasive breast cancer cell line, to e

130 f the mRNA was also pronounced in the dorsal dedifferentiating iris and the regenerating lens.

131 amming, the propensity of committed cells to dedifferentiate is inversely correlated to their state o

132 have a similar expression pattern to that of dedifferentiated islets.

133 compatible either with myeloid cell or with dedifferentiated Langerhans cell antigens, carry the BRA

134 Many dedifferentiated, late-stage tumors are resistant to gro

135 Dedifferentiated liposarcoma (DDLPS) is a highly maligna

136 ecimens of WDLPS, and of the closely related dedifferentiated liposarcoma (DDLPS) subtype, revealed i

137 and expression of FRS2 with CDK4 and MDM2 in dedifferentiated liposarcoma (DDLS) and undifferentiated

138 e well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS), both characterized

139 tissue, well-differentiated liposarcoma, and dedifferentiated liposarcoma by both deep sequencing of

140 In the human dedifferentiated liposarcoma cell line (LS141) and the p

141 assigned an important role in the growth of dedifferentiated liposarcoma cell lines.

142 ially induces apoptosis and growth arrest in dedifferentiated liposarcoma cells compared with normal

143 Restoring miR-143 expression in dedifferentiated liposarcoma cells inhibited proliferati

144 d checkpoint pathways in well-differentiated/dedifferentiated liposarcoma provides several possible n

145 Dedifferentiated liposarcoma represents focal progressio

146 Multivariate analysis showed that dedifferentiated liposarcoma subtype was associated with

147 Retroperitoneal dedifferentiated liposarcoma was associated with an 83%

148 logies were well-differentiated liposarcoma, dedifferentiated liposarcoma, and leiomyosarcoma.

149 ased knockdown of several genes amplified in dedifferentiated liposarcoma, including CDK4 and YEATS4,

150 or its targets may have therapeutic value in dedifferentiated liposarcoma.

151 ng seven (47%) of 15 evaluable patients with dedifferentiated liposarcoma.

152 in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

153 with undifferentiated pleomorphic sarcoma or dedifferentiated liposarcoma.

154 ograft models from surgically resected human dedifferentiated liposarcoma.

155 d in > 90% of well-differentiated (WDLS) and dedifferentiated liposarcomas (DDLS).

156 More than 90% of well-differentiated or dedifferentiated liposarcomas (WD/DDLS) have CDK4 amplif

157 Well-differentiated and dedifferentiated liposarcomas (WDLS/DDLS) account for ap

158 ned over 40 miRNAs that were dysregulated in dedifferentiated liposarcomas in both the sequencing and

159 -associated neochromosomes from well- and/or dedifferentiated liposarcomas.

160 the catalytic subunit alpha2, is induced in dedifferentiated liver.

161 of which well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) are the most common.

162 The Ad/N1ICD LPS resembles human dedifferentiated LPS in histological appearance, anatomi

163 ch inhibition suppresses the growth of human dedifferentiated LPS xenografts.

164 ifferentiate first, and that what makes them dedifferentiate may be the presence of thrombin in combi

165 The dedifferentiated melanoma cells acquired features associ

166 The dedifferentiated melanoma cells showed significantly dec

167 In the dedifferentiated mesenchymal CT26 cells, TGFbetaRII-dn c

168 Muller glia in adult mice can be induced to dedifferentiate, migrate, and generate new retinal neuro

169 ponsiveness of renal epithelial cells to the dedifferentiating morphogenic signals of hepatocyte grow

170 Compared to parental cardiomyocytes, dedifferentiated mouse cardiomyocyte-derived CPCs (mCPCs

171 and that they were induced in proliferating, dedifferentiated Muller glia.

172 Specifically, constitutive Notch1 activation dedifferentiates myocytes into Pax7 quiescent satellite

173 nts >/= 18 years with advanced or metastatic dedifferentiated, myxoid/round cell, or pleomorphic LPS

174 riovenous fistula samples after occlusion by dedifferentiated neointimal VSMC.

175 We detected this dedifferentiated neural crest subpopulation in all estab

176 ues as to how adult beta cells can partially dedifferentiate or become reprogrammed into other islet

177 eased cell death, suggesting that otic cells dedifferentiate or redifferentiate as other cell type(s)

178 xpressed with keratins, thus presenting as a dedifferentiated or interconverted (between epithelial a

179 firmed that new bone cells do not arise from dedifferentiated osteoblasts under these conditions.

180 Primary hepatocytes cultured without matrix dedifferentiate over time, but matrix overlay quickly re

181 dence that Notch signaling is reactivated in dedifferentiated pancreatic cells.

182 Prolonged Notch activation within dedifferentiated parietal cells eventually enhances cell

183 GCPs cultured at 38 degrees C without ABA dedifferentiate partially but do not divide.

184 % cell death, and surviving RPTCs acquired a dedifferentiated phenotype (e.g. elongated morphology an

185 de that ERalpha activation switched SMC to a dedifferentiated phenotype and may contribute to plaque

186 C/R247C) SMCs to a Rho activator rescued the dedifferentiated phenotype of the SMCs.

187 lved in this process, wherein they express a dedifferentiated phenotype that transiently resembles ne

188 resulted in the opposite effect and led to a dedifferentiated phenotype via a different G protein pat

189 tch Schwann cells between the myelinated and dedifferentiated phenotypes, respectively.

190 n of these genes was readily observed in the dedifferentiating pigmented epithelial cells, and the le

191 together with previous reports showing that dedifferentiated Pkd1-deficient cells express lower p53

192 e vegetative nucleus of pollen grains and in dedifferentiated plant cell cultures.

193 Human metastatic melanoma cells express a dedifferentiated, plastic phenotype, which may serve as

194 markedly decreased in the proliferating and dedifferentiated podocytes of mice with anti-glomerular

195 s impaired is thought to be mediated by oval/dedifferentiated progenitor cells, which replenish the h

196 lls originate from normal stem cells or from dedifferentiated progenitor cells.

197 eIF4E is up-regulated in these dedifferentiating progenitors, where it forms a feedback

198 f insulin and FGF2 stimulated Muller glia to dedifferentiate, proliferate, and generate new neurons.

199 to the chicken retina causes Muller glia to dedifferentiate, proliferate, express transcription fact

200 rnate between nondividing differentiated and dedifferentiated proliferating states in vivo.

201 recent studies show that a subpopulation of dedifferentiated, proliferating tubules recovering from

202 type from a quiescent contractile state to a dedifferentiated, proliferative and migratory state duri

203 escent vascular smooth muscle cells assume a dedifferentiated, proliferative phenotype in response to

204 topic p-Creb expression/cAMP signaling marks dedifferentiated proximal tubular cystic segments.

205 high levels in human and rodent kidneys with dedifferentiated proximal tubule epithelial cells after

206 9 markers of immature nephron structures and dedifferentiated proximal tubules after acute kidney inj

207 ss of retinal neurons, Muller glia partially dedifferentiate, re-express neuroepithelial markers and

208 xpand 20- to 30-fold, regenerate cell walls, dedifferentiate, reenter the cell cycle, and divide.

209 5- to 6-fold; they do not regenerate walls, dedifferentiate, reenter the cell cycle, or divide.

210 ion constitutes an active mechanism allowing dedifferentiated regenerating cells to scatter on denude

211 C3 was expressed in the dedifferentiated regeneration blastema and in the rediff

212 pe I transmembrane glycoprotein expressed on dedifferentiated renal proximal tubule epithelial cells

213 es, primary human hepatocytes (PHHs) rapidly dedifferentiate, resulting in loss of hepatic functions

214 hwann cells degrade their myelin sheaths and dedifferentiate, reverting to a phenotype that supports

215 tgrowth of cultured RPE sheets and prevented dedifferentiated RPE cell proliferation and migration.

216 ved in formation of contractile membranes by dedifferentiated RPE cells and suggest that adjunctive t

217 ibited formation of contractile membranes by dedifferentiated RPE cells on collagen I matrices.

218 ll-cell contact and demonstrate that forcing dedifferentiated RPE cells to adopt cell-cell only conta

219 ed to diminish Zeb1 expression and reprogram dedifferentiated RPE cells.

220 in nuclear translocation of beta-catenin in dedifferentiated RPE cells.

221 Furthermore, wound and distal dedifferentiated Schwann cells constitute different popu

222 Moreover, the authors show that dedifferentiated Schwann cells have the potential to coo

223 00 protein-negative cells in MPNST represent dedifferentiated Schwann cells, which harbor NF1 deletio

224 Schwannomas develop from proliferation of dedifferentiated Schwann cells, which normally wrap nerv

225 hickness and axon size distribution but some dedifferentiated SCs and increased macrophage infiltrati

226 enriched in contractile SMCs but reduced in dedifferentiated SMCs.

227 uscle cells (SMC) from a differentiated to a dedifferentiated state is the critical phenotypic respon

228 r CHAF1A functions in maintaining the highly dedifferentiated state of this aggressive malignancy.

229 ls, resulting in acinar-ductal metaplasia, a dedifferentiated state that is poised for oncogenic tran

230 s that RPE are lost rather than persist in a dedifferentiated state.

231 uctive tissues and for sustained growth in a dedifferentiated state.

232 molecular identity of the differentiated and dedifferentiated states in vivo has been elusive.

233 s and progression in the well-differentiated/dedifferentiated subset.

234 differentiated "contractile" phenotype to a dedifferentiated "synthetic" one.

235 of the reprogrammed cancer cells, in essence dedifferentiating them to a state slightly before the me

236 crine pancreas and the intestinal epithelium dedifferentiate to a progenitor state and then rediffere

237 one (TH) induces the tadpole acinar cells to dedifferentiate to a progenitor state.

238 "Sensing" damaged axons, they dedifferentiate to a progenitor-like state, in which the

239 t players in this process, during which they dedifferentiate to a progenitor/stem cell and promote ax

240 erentiated astrocytes and neurons, which can dedifferentiate to a stem cell-like state upon transform

241 For instance, upon damage cells can dedifferentiate to acquire stem cell potential that allo

242 ial cells of the dorsal iris proliferate and dedifferentiate to form a lens vesicle, which subsequent

243 st proximal to the amputation plane begin to dedifferentiate to form a pool of proliferating progenit

244 In this process, mature osteoblasts dedifferentiate to osteogenic precursor cells and thus r

245 within the full spectrum from RAI-refractory dedifferentiated to ATC.

246 etamorphic climax when the exocrine pancreas dedifferentiates to progenitor cells, the beta-cells und

247 out the mechanisms that prevent neurons from dedifferentiating to a multipotent, stem cell-like state

248 RNAs in progestin-mediated expansion of this dedifferentiated tumor cell population.

249 tumors and normal fat specimens identified a dedifferentiated tumor expression signature consisting o

250 early-stage (differentiated) and late-stage (dedifferentiated) tumors.

251 In lola mutants, neurons dedifferentiate, turn on neural stem cell genes, and beg

252 myelin sheaths around axons and also rapidly dedifferentiate upon injury.

253 ontrary to the antimotogenic effect of NO in dedifferentiated vascular smooth muscle cells (VSMCs), w

254 In vitro, the expression level of miR-21 in dedifferentiated vascular smooth muscle cells was signif

255 proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in r

256 xpressed highly in differentiated but not in dedifferentiated VSMC.

257 ury, the expression of ACLP increases in the dedifferentiated VSMCs of the neointima in a pattern tha

258 neointimal lesion formation and in cultured dedifferentiated VSMCs.

259 de a novel tool to target gene expression to dedifferentiated VSMCs.

260 se data indicate that mammalian myotubes can dedifferentiate when stimulated with the appropriate fac

261 inally differentiated mammalian myotubes can dedifferentiate when stimulated with the appropriate sig

262 The epithelial cell clone dedifferentiated when grown on plastic; however, the cel