ライフサイエンスコーパス: dedifferentiated

1 s, and these SMCs are hyperproliferative and dedifferentiated.

2 1 isoform A3 (ALDH(+)) as beta cells become dedifferentiated.

3 Plant cells rapidly dedifferentiated.

4 d enriched among cells that were injured and dedifferentiated.

5 resented with well-differentiated, 143 (18%) dedifferentiated, 144 (18%) myxoid, 81 (10%) round cell,

6 quently amplified in G2 (15%), G3 (20%), and dedifferentiated (21%) chondrosarcomas.

7 constructed tissue microarrays containing 42 dedifferentiated, 23 clear cell, and 23 mesenchymal chon

8 e 1 (18%), grade 2 (31%), grade 3 (80%), and dedifferentiated (29%) chondrosarcomas, but was not foun

9 nted with well-differentiated, 65 (37%) with dedifferentiated, 9 (5%) with myxoid, and 4 (2%) with ro

10 ancreatic injury, elimination of Numb causes dedifferentiated acinar cells to undergo apoptosis, and

11 Chondrocytes in monolayer become dedifferentiated, acquiring a fibroblast-like appearance

12 state of differentiation because SCs rapidly dedifferentiated and became competent to resume prolifer

13 or progenitor cells or from cells that have dedifferentiated and become proliferative.

14 Claudin-3-/- mice revealed dedifferentiated and leaky colonic epithelium, and devel

15 p of tumors in Arf(-/-) animals presented as dedifferentiated and metastatic, with many characteristi

16 , reduces invasion, and induces apoptosis in dedifferentiated and myxoid/round cell liposarcoma cell

17 olecule up-regulated in the cells, which are dedifferentiated and undergoing replication.

18 as quickly down-regulated and disappeared in dedifferentiated ASMC in culture.

19 In this study, we confirmed that transformed dedifferentiated astrocytes and neurons acquired a stem/

20 pmentally stalled neural progenitors or from dedifferentiated astrocytes?

21 ssing five subtypes, (a) well-differentiated/dedifferentiated, (b) myxoid/round cell, and (c) pleomor

22 Dedifferentiated beta cells reverted to progenitor-like

23 At an early stage, melanoma cells showed a dedifferentiated c-Jun(high)/MITF(low) phenotype, possib

24 lial cell preservation and conversion into a dedifferentiated cancer stem cell-like phenotype depends

25 t encompasses well-differentiated as well as dedifferentiated cancer types.

26 could be detected in similar assays with the dedifferentiated cell line HepG2.1 or the nonhepatic cel

27 val may be manifested by the production of a dedifferentiated cell with broader potential and that th

28 eration, we find no evidence to suggest that dedifferentiated cells acquire a ductal fate during this

29 , the proliferation and the migration of the dedifferentiated cells are dependent on Hh signaling.

30 transcription factors and that diseased and dedifferentiated cells can be returned to normal functio

31 transition, and exogenous PHD2 expression in dedifferentiated cells can restore an epithelial phenoty

32 and three IR-resistant clones isolated from dedifferentiated cells have acquired the ability to prol

33 RNAi-mediated knockdown of Oct4 in dedifferentiated cells led to diminished CSC phenotypes.

34 n organized structure of lineage restricted, dedifferentiated cells that cooperate to regenerate the

35 Dedifferentiated cells were morphologically indistinguis

36 lular matrix, and proliferation of partially dedifferentiated cells, evidence strongly supports the l

37 e can restore chondrocyte gene expression in dedifferentiated chondrocytes grown on plastic.

38 Subsequent culture of the dedifferentiated chondrocytes in 3-dimensional alginate

39 Culture of dedifferentiated chondrocytes in alginate gel induces a

40 as 2-3-fold greater in nuclear extracts from dedifferentiated chondrocytes than in nuclear extracts f

41 in complex formed with nuclear extracts from dedifferentiated chondrocytes were 2-3-fold greater than

42 binding activity between differentiated and dedifferentiated chondrocytes.

43 ition with the BH-3 mimetic ABT-737 rendered dedifferentiated chondrosarcoma cell lines sensitive to

44 The mesenchymal, clear cell, and dedifferentiated chondrosarcoma subtypes are extremely r

45 comas, one pleomorphic rhabdomyosarcoma, one dedifferentiated chondrosarcoma, and one malignant perip

46 a survivors; the benefit of chemotherapy for dedifferentiated chondrosarcomas remains questionable; a

47 lanted from the Myh11(R247C/R247C) mice were dedifferentiated compared with wild-type SMCs based on i

48 d TGF-beta down-regulated GKLF expression in dedifferentiated cultured SMCs.

49 adipose tissue and well differentiated from dedifferentiated disease.

50 Insulin-producing beta cells become dedifferentiated during diabetes progression.

51 Conversion of SECs to a capillarized, dedifferentiated endothelium was confirmed at the cellul

52 lia promotes BMP7 signaling in repopulating, dedifferentiated epithelia.

53 KC and KCR8-16 mice developed dedifferentiated exocrine pancreata within 2 months of a

54 liferation were seen in conjunction with the dedifferentiated expression of cytokeratins 1, 10 and 5,

55 Human SMCs are first dedifferentiated for 4 days to achieve a vascular progen

56 Tumors derived from dedifferentiated germ cells, however, respond to the pro

57 in germline stem cell overproliferation and dedifferentiated germline stem cells.

58 undergoes pX-dependent transformation and a dedifferentiated hepatocyte (AML12) 4pX-1 cell line that

59 addition of hydrated matrix preparations to dedifferentiated hepatocytes.

60 rs by transient-transfection analysis in the dedifferentiated hepatoma cell line, HepG2.1.

61 plastic tissue culture flasks as monolayers (dedifferentiated HFC cultures).

62 ferentiation that was also down-regulated in dedifferentiated hfRPE cells.

63 he RPE, were significantly down-regulated in dedifferentiated hfRPE cells.

64 ted primary human fetal RPE (hfRPE) cells to dedifferentiated hfRPE cells.

65 8 mm), node negative in 93.4% of cases, and dedifferentiated (high-grade cancer) in 41.7% of cases a

66 Dedifferentiated histologic subtype and the need for con

67 Risk of recurrence is high for patients with dedifferentiated histology or retroperitoneal location.

68 The exocrine-enriched cells rapidly dedifferentiated in culture and grew as a mesenchymal mo

69 decidual cells from patients with sPE, which dedifferentiated in vitro, failed to redecidualize in cu

70 etic marks, and the mature B cells partially dedifferentiated, induced RAG-1 and -2 along with certai

71 ence, there is no apparent requirement for a dedifferentiated intermediate during the transdifferenti

72 tially dispensable but becomes essential for dedifferentiated intermediates to transit to ground stat

73 y enlarged, disorganized, and in some cases, dedifferentiated into a callusoid mass.

74 strated that the luminal secretory cells had dedifferentiated into basal stem cells.

75 r hepatocyte loss, BECs proliferated as they dedifferentiated into hepatoblast-like cells; they subse

76 Single secretory cells clonally dedifferentiated into multipotent stem cells when they w

77 pe, we engineered MDA-MB-231 cells, a highly dedifferentiated, invasive breast cancer cell line, to e

78 have a similar expression pattern to that of dedifferentiated islets.

79 compatible either with myeloid cell or with dedifferentiated Langerhans cell antigens, carry the BRA

80 Many dedifferentiated, late-stage tumors are resistant to gro

81 Dedifferentiated liposarcoma (DDLPS) is a highly maligna

82 ecimens of WDLPS, and of the closely related dedifferentiated liposarcoma (DDLPS) subtype, revealed i

83 and expression of FRS2 with CDK4 and MDM2 in dedifferentiated liposarcoma (DDLS) and undifferentiated

84 e well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS), both characterized

85 tissue, well-differentiated liposarcoma, and dedifferentiated liposarcoma by both deep sequencing of

86 In the human dedifferentiated liposarcoma cell line (LS141) and the p

87 assigned an important role in the growth of dedifferentiated liposarcoma cell lines.

88 ially induces apoptosis and growth arrest in dedifferentiated liposarcoma cells compared with normal

89 Restoring miR-143 expression in dedifferentiated liposarcoma cells inhibited proliferati

90 d checkpoint pathways in well-differentiated/dedifferentiated liposarcoma provides several possible n

91 Dedifferentiated liposarcoma represents focal progressio

92 Multivariate analysis showed that dedifferentiated liposarcoma subtype was associated with

93 Retroperitoneal dedifferentiated liposarcoma was associated with an 83%

94 logies were well-differentiated liposarcoma, dedifferentiated liposarcoma, and leiomyosarcoma.

95 ased knockdown of several genes amplified in dedifferentiated liposarcoma, including CDK4 and YEATS4,

96 ng seven (47%) of 15 evaluable patients with dedifferentiated liposarcoma.

97 in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

98 with undifferentiated pleomorphic sarcoma or dedifferentiated liposarcoma.

99 ograft models from surgically resected human dedifferentiated liposarcoma.

100 or its targets may have therapeutic value in dedifferentiated liposarcoma.

101 d in > 90% of well-differentiated (WDLS) and dedifferentiated liposarcomas (DDLS).

102 More than 90% of well-differentiated or dedifferentiated liposarcomas (WD/DDLS) have CDK4 amplif

103 Well-differentiated and dedifferentiated liposarcomas (WDLS/DDLS) account for ap

104 ned over 40 miRNAs that were dysregulated in dedifferentiated liposarcomas in both the sequencing and

105 -associated neochromosomes from well- and/or dedifferentiated liposarcomas.

106 the catalytic subunit alpha2, is induced in dedifferentiated liver.

107 of which well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) are the most common.

108 The Ad/N1ICD LPS resembles human dedifferentiated LPS in histological appearance, anatomi

109 ch inhibition suppresses the growth of human dedifferentiated LPS xenografts.

110 The dedifferentiated melanoma cells acquired features associ

111 The dedifferentiated melanoma cells showed significantly dec

112 In the dedifferentiated mesenchymal CT26 cells, TGFbetaRII-dn c

113 Compared to parental cardiomyocytes, dedifferentiated mouse cardiomyocyte-derived CPCs (mCPCs

114 and that they were induced in proliferating, dedifferentiated Muller glia.

115 nts >/= 18 years with advanced or metastatic dedifferentiated, myxoid/round cell, or pleomorphic LPS

116 riovenous fistula samples after occlusion by dedifferentiated neointimal VSMC.

117 We detected this dedifferentiated neural crest subpopulation in all estab

118 xpressed with keratins, thus presenting as a dedifferentiated or interconverted (between epithelial a

119 firmed that new bone cells do not arise from dedifferentiated osteoblasts under these conditions.

120 dence that Notch signaling is reactivated in dedifferentiated pancreatic cells.

121 Prolonged Notch activation within dedifferentiated parietal cells eventually enhances cell

122 % cell death, and surviving RPTCs acquired a dedifferentiated phenotype (e.g. elongated morphology an

123 de that ERalpha activation switched SMC to a dedifferentiated phenotype and may contribute to plaque

124 C/R247C) SMCs to a Rho activator rescued the dedifferentiated phenotype of the SMCs.

125 lved in this process, wherein they express a dedifferentiated phenotype that transiently resembles ne

126 resulted in the opposite effect and led to a dedifferentiated phenotype via a different G protein pat

127 tch Schwann cells between the myelinated and dedifferentiated phenotypes, respectively.

128 together with previous reports showing that dedifferentiated Pkd1-deficient cells express lower p53

129 e vegetative nucleus of pollen grains and in dedifferentiated plant cell cultures.

130 Human metastatic melanoma cells express a dedifferentiated, plastic phenotype, which may serve as

131 markedly decreased in the proliferating and dedifferentiated podocytes of mice with anti-glomerular

132 s impaired is thought to be mediated by oval/dedifferentiated progenitor cells, which replenish the h

133 lls originate from normal stem cells or from dedifferentiated progenitor cells.

134 rnate between nondividing differentiated and dedifferentiated proliferating states in vivo.

135 recent studies show that a subpopulation of dedifferentiated, proliferating tubules recovering from

136 type from a quiescent contractile state to a dedifferentiated, proliferative and migratory state duri

137 escent vascular smooth muscle cells assume a dedifferentiated, proliferative phenotype in response to

138 topic p-Creb expression/cAMP signaling marks dedifferentiated proximal tubular cystic segments.

139 high levels in human and rodent kidneys with dedifferentiated proximal tubule epithelial cells after

140 9 markers of immature nephron structures and dedifferentiated proximal tubules after acute kidney inj

141 ion constitutes an active mechanism allowing dedifferentiated regenerating cells to scatter on denude

142 C3 was expressed in the dedifferentiated regeneration blastema and in the rediff

143 pe I transmembrane glycoprotein expressed on dedifferentiated renal proximal tubule epithelial cells

144 tgrowth of cultured RPE sheets and prevented dedifferentiated RPE cell proliferation and migration.

145 ved in formation of contractile membranes by dedifferentiated RPE cells and suggest that adjunctive t

146 ibited formation of contractile membranes by dedifferentiated RPE cells on collagen I matrices.

147 ll-cell contact and demonstrate that forcing dedifferentiated RPE cells to adopt cell-cell only conta

148 ed to diminish Zeb1 expression and reprogram dedifferentiated RPE cells.

149 in nuclear translocation of beta-catenin in dedifferentiated RPE cells.

150 Furthermore, wound and distal dedifferentiated Schwann cells constitute different popu

151 Moreover, the authors show that dedifferentiated Schwann cells have the potential to coo

152 00 protein-negative cells in MPNST represent dedifferentiated Schwann cells, which harbor NF1 deletio

153 Schwannomas develop from proliferation of dedifferentiated Schwann cells, which normally wrap nerv

154 hickness and axon size distribution but some dedifferentiated SCs and increased macrophage infiltrati

155 enriched in contractile SMCs but reduced in dedifferentiated SMCs.

156 uscle cells (SMC) from a differentiated to a dedifferentiated state is the critical phenotypic respon

157 r CHAF1A functions in maintaining the highly dedifferentiated state of this aggressive malignancy.

158 ls, resulting in acinar-ductal metaplasia, a dedifferentiated state that is poised for oncogenic tran

159 s that RPE are lost rather than persist in a dedifferentiated state.

160 uctive tissues and for sustained growth in a dedifferentiated state.

161 molecular identity of the differentiated and dedifferentiated states in vivo has been elusive.

162 s and progression in the well-differentiated/dedifferentiated subset.

163 differentiated "contractile" phenotype to a dedifferentiated "synthetic" one.

164 within the full spectrum from RAI-refractory dedifferentiated to ATC.

165 RNAs in progestin-mediated expansion of this dedifferentiated tumor cell population.

166 tumors and normal fat specimens identified a dedifferentiated tumor expression signature consisting o

167 early-stage (differentiated) and late-stage (dedifferentiated) tumors.

168 ontrary to the antimotogenic effect of NO in dedifferentiated vascular smooth muscle cells (VSMCs), w

169 In vitro, the expression level of miR-21 in dedifferentiated vascular smooth muscle cells was signif

170 proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in r

171 xpressed highly in differentiated but not in dedifferentiated VSMC.

172 ury, the expression of ACLP increases in the dedifferentiated VSMCs of the neointima in a pattern tha

173 neointimal lesion formation and in cultured dedifferentiated VSMCs.

174 de a novel tool to target gene expression to dedifferentiated VSMCs.

175 The epithelial cell clone dedifferentiated when grown on plastic; however, the cel