ライフサイエンスコーパス: dedifferentiation

1 ed with chronic pancreatitis and acinar cell dedifferentiation.

2 es cultured for long periods of time undergo dedifferentiation.

3 esting an underlying defect in cardiomyocyte dedifferentiation.

4 l death response is an instrument to achieve dedifferentiation.

5 neoplasia, including altered metabolism and dedifferentiation.

6 ong-term enigma has been how injury leads to dedifferentiation.

7 ion by suppressing pluripotency and cellular dedifferentiation.

8 he germline could be attributed to defective dedifferentiation.

9 to impaired insulin secretion and beta cell dedifferentiation.

10 inhibition or knockdown facilitated podocyte dedifferentiation.

11 wn-regulation of Gata6 to induce acinar cell dedifferentiation.

12 olar macrophages, and promoted myofibroblast dedifferentiation.

13 expression correlates with invasiveness and dedifferentiation.

14 gulated, linking malignant transformation to dedifferentiation.

15 by preventing Rokalpha-mediated keratinocyte dedifferentiation.

16 ell was sufficient to prevent secretory cell dedifferentiation.

17 sidues that are hydroxylated by PHD2 induces dedifferentiation.

18 still increase during the period of plastid dedifferentiation.

19 e that Oct4 is a positive regulator of tumor dedifferentiation.

20 excessive signaling, resulting in cancerous dedifferentiation.

21 inhibitor 5-azacytidine, enforces astrocyte dedifferentiation.

22 , confirming previous reports of age-related dedifferentiation.

23 s adding miR-204/211 inhibitors led to their dedifferentiation.

24 otype is dynamic and may be acquired through dedifferentiation.

25 s, they provide evidence for their transient dedifferentiation.

26 ased miR-204/211 expression and caused hfRPE dedifferentiation.

27 r, whereas later upgrading may reflect tumor dedifferentiation.

28 thought to be derived from mature cells via dedifferentiation.

29 ating receptor tyrosine kinases (RTKs) on SC dedifferentiation.

30 d by antagonizing Notch signaling to prevent dedifferentiation.

31 saged and subcultured in monolayer to induce dedifferentiation.

32 C proliferation and phenotypic switch toward dedifferentiation.

33 set of effector T cells through a process of dedifferentiation.

34 ory cytokine tumor necrosis factor alpha, or dedifferentiation.

35 ty in medulla neurons and prevents them from dedifferentiation.

36 bellum, which points to potential brain cell dedifferentiation.

37 These changes lead to beta-cell dedifferentiation.

38 sion from beta-cell dysfunction to beta-cell dedifferentiation.

39 ersistent inflammation, fibrosis, and acinar dedifferentiation.

40 t phosphate cotransporter, suggesting apical dedifferentiation accounting for Fanconi syndrome before

41 Furthermore, increased proliferation, dedifferentiation, activation of the DNA damage response

42 l divisions being asymmetric), we found that dedifferentiation acts like a positive selective force i

43 CONCLUSIONS/SIGNIFICANCE: The lack of dedifferentiation amongst supporting cells and their rep

44 f TGF-beta, leading to renal proximal tubule dedifferentiation, an important event in the pathogenesi

45 ecombinant AZGP1 inhibited kidney epithelial dedifferentiation and antagonized fibroblast activation

46 sponse that is initiated by Muller Glia (MG) dedifferentiation and asymmetric cell division to produc

47 er limb regeneration-wound healing, cellular dedifferentiation and blastemal formation-will reveal th

48 he signaling mechanisms that govern cellular dedifferentiation and blastemal progenitors are unknown.

49 avel the molecular mechanisms underlying the dedifferentiation and cell cycle reentry of mouse ACMs.

50 specific EGFR activation promoted epithelial dedifferentiation and cell-cycle arrest.

51 n is induced in tubular epithelia undergoing dedifferentiation and contributes to the fibrotic respon

52 ation of MAPK/ERK has been shown to cause SC dedifferentiation and demyelination.

53 neural progenitors (INPs) need to avoid both dedifferentiation and differentiation during neurogenesi

54 tractional forces as key determinants of the dedifferentiation and differentiation stages during repr

55 or suppressor pathway is essential for tumor dedifferentiation and dissemination both in genetically

56 of TSC1 and activation of mTORC1 results in dedifferentiation and dysfunction of the CD and causes h

57 Overexpression of IGF2 led to beta-cell dedifferentiation and endoplasmic reticulum stress causi

58 leads to vascular smooth muscle cell (VSMC) dedifferentiation and enhances responses to IGF-I.

59 jury triggers a regenerative program through dedifferentiation and epicardial activation is a critica

60 Cirrhosis is associated with cell dedifferentiation and expansion of hepatocholangiolar pr

61 e initial-segment epithelium and resulted in dedifferentiation and extensive epithelial folding.

62 fntb as critical regulators of cardiomyocyte dedifferentiation and heart regeneration in zebrafish.

63 islets in T2D display changes reminiscent of dedifferentiation and highlight SOX5 as a regulator of b

64 FR-ERK signaling mediates renal tubular cell dedifferentiation and identifies a novel molecular mecha

65 r machinery in mice results in cardiomyocyte dedifferentiation and improved heart functionality after

66 ch labeled clones proliferated and expressed dedifferentiation and injury markers.

67 lial cells caused ATP depletion, cell death, dedifferentiation and intracellular lipid deposition, ph

68 The mechanisms underlying the dedifferentiation and lineage conversion of adult human

69 ugh defective acidification, thereby causing dedifferentiation and loss of reabsorptive capacity of P

70 interactions between SRC-1 and Ets2 promote dedifferentiation and migration in hormone-dependent bre

71 phages amplifies demyelination, Schwann cell dedifferentiation and perturbation of axons.

72 R inhibitor rapamycin blunted key aspects of dedifferentiation and preserved photoreceptor function f

73 riguingly, NFATc1-Sox2 complex-mediated PDAC dedifferentiation and progression is opposed by antithet

74 We have reported that BCD cell dedifferentiation and proliferation in vitro correlate w

75 rdial regeneration in zebrafish involves the dedifferentiation and proliferation of cardiomyocytes to

76 last growth factor-2 (FGF-2), can induce the dedifferentiation and proliferation of cultured human po

77 brafish fin ray bone regenerates through the dedifferentiation and proliferation of spared osteoblast

78 R-34a interacted with positive regulators of dedifferentiation and proliferation such as Notch1 and C

79 he compliant microenvironment facilitates CM dedifferentiation and proliferation via its effect on th

80 symbiotic nodules are formed as a result of dedifferentiation and reactivation of cortical root cell

81 n differentiated visceral SMCs induced their dedifferentiation and reduced their contractility by up-

82 ll apoptosis and necrosis, oxidative stress, dedifferentiation and regenerative cell proliferation, r

83 rent stem-cell markers during injury-induced dedifferentiation and repair.

84 we show that Sox2 is required for initiating dedifferentiation and that inhibition of Ezh2 promotes m

85 s and subjected to long-term culture undergo dedifferentiation and that these cells can be redifferen

86 a) inhibition was sufficient to stimulate MG dedifferentiation and the formation of multipotent retin

87 acts intrinsically in germ cells to activate dedifferentiation and thus replenish lost GSCs during bo

88 overexpression of FIR correlates with tumor dedifferentiation and tumor cell proliferation in about

89 pic Notch activation is sufficient to induce dedifferentiation and tumorigenic transformation of matu

90 moting the disruption of adherens junctions, dedifferentiation, and an epithelial to mesenchymal tran

91 tribute to intestinal metaplasia, epithelial dedifferentiation, and carcinogenesis in the human stoma

92 regeneration; inhibiting cell cycle reentry, dedifferentiation, and cell division; and suppressing ac

93 Prrx1b promotes invasion, tumor dedifferentiation, and EMT.

94 ays in carcinogenesis, such as angiogenesis, dedifferentiation, and invasion.

95 that ocular treatment prevents tumor growth, dedifferentiation, and metastatic disease in some patien

96 The results herein indicate that beta-cell dedifferentiation, and not necessarily endocrine cell lo

97 ulated expression of fibrotic genes, induced dedifferentiation, and orchestrated epithelial cell-cycl

98 s is Aldh1a3, a putative marker of beta-cell dedifferentiation, and other genes associated with beta-

99 miRNAs are important drivers of hepatic dedifferentiation, and our results provide valuable info

100 phages amplifies demyelination, Schwann cell dedifferentiation, and perturbation of axons.

101 RCA1 suppressed TWIST and EMT, inhibited LSC dedifferentiation, and repressed expansion of basal stem

102 uced autophagy, enhanced tumor growth, tumor dedifferentiation, and resistance to TKI therapy.

103 processes such as wound healing, cell death, dedifferentiation, and stem (or progenitor) cell prolife

104 To date, mechanisms of preventing neuron dedifferentiation are still unclear, especially in the o

105 The mechanisms underlying MG dedifferentiation are unknown.

106 g data from Talchai et al. suggest beta cell dedifferentiation as an alternative mechanism of insulin

107 atments resulted in a reduction of beta-cell dedifferentiation, as assessed by Foxo1 and Aldh1a3 immu

108 show increased proliferation and anaplastic dedifferentiation, as well as mTORC1 hyperactivation wit

109 ty at the promoters of procontractile versus dedifferentiation-associated genes.

110 ty, while also restoring cell proliferation, dedifferentiation-associated repair and regeneration of

111 rogenitor-based mechanism (larval mode) to a dedifferentiation-based one (adult mode) as it transits

112 Dedifferentiation began in middle age, and continued int

113 In summary, dedifferentiation begins relatively early in adulthood a

114 ric and asymmetric divisions), we found that dedifferentiation beyond a critical threshold leads to e

115 a in cells that express PHD2 does not induce dedifferentiation but expression of HIF-1alpha containin

116 lts demonstrate that the ESCC miRNAs promote dedifferentiation by acting on multiple downstream pathw

117 Inflammation, cell hypertrophy, and dedifferentiation by the activation of classic pathways

118 Our evidence suggests that human cell dedifferentiation can be achieved through autonomously c

119 In this study, we asked whether beta-cell dedifferentiation can be prevented with diet or pharmaco

120 tion of the FHL2 gene mitigated the podocyte dedifferentiation caused by activated Wnt/beta-catenin s

121 actin, and desmin, and increased markers of dedifferentiation, cellular retinol-binding protein 1, a

122 at various time points during the course of dedifferentiation cultures revealed that hepatocytes rap

123 It is followed by chloroplast dedifferentiation/degeneration that starts at the end of

124 re entire limbs has been largely linked to a dedifferentiation-dependent mechanism of regeneration.

125 e that Brca1 directly suppresses EMT and LSC dedifferentiation during breast tumorigenesis.

126 determination during normal development and dedifferentiation during disease.

127 Here we show that skeletal muscle dedifferentiation during newt limb regeneration depends

128 nscriptome dynamics during the initiation of dedifferentiation during the first 24 hours of culture.

129 he epigenetic landscape, leading to cellular dedifferentiation, enhanced mesenchymal transition, and

130 Finally, besides inducing epithelial dedifferentiation, exogenous TGF-beta1 dose-dependently

131 ithelial cells (i.e., one involving cellular dedifferentiation followed by redifferentiation).

132 long-term PDL induced significant beta-cell dedifferentiation, followed by a time-dependent decrease

133 and protects these neurons from cholinergic dedifferentiation following axotomy when administered in

134 n mice blocks Schwann cell demyelination and dedifferentiation following nerve injury, suggesting tha

135 Schwann cell dedifferentiation from a myelinating to a progenitor-lik

136 These tumors may represent a spectrum of dedifferentiation from classic PTC to anaplastic thyroid

137 Recently, beta-cell dedifferentiation has been shown to be an important cont

138 More specifically, dedifferentiation in FFA activity may be due to broadeni

139 Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones.

140 We also observed formation of PGCCs and dedifferentiation in ovarian cancer specimens from patie

141 and improve our understanding of liver cell dedifferentiation in pathologic conditions.

142 s used to examine mRNA expression during RPE dedifferentiation in primary cultures of RPE cells and a

143 gs suggest a fundamental role for osteoblast dedifferentiation in reparative bone formation in fish a

144 d the TCF Elk-1, resulting in a reduced VSMC dedifferentiation in response to flow cessation or vascu

145 ion factors MafA and Pdx1 point to beta-cell dedifferentiation in the absence of pericytes.

146 ing curves for face-selective neurons, while dedifferentiation in the extended face network reflects

147 In contrast, dedifferentiation in the extended face network was drive

148 sistent with the broadening hypothesis, this dedifferentiation in the fusiform face area (FFA) was dr

149 progression from metabolic inflexibility to dedifferentiation in the natural history of beta-cell fa

150 The recognition of beta cell dedifferentiation in type 2 diabetes raises the translat

151 feature of chondrocytes that have undergone dedifferentiation in vitro and osteoarthritic chondrocyt

152 TGF-beta has been shown to induce podocyte dedifferentiation in vitro, but its in vivo effects on t

153 n sulfide production, and smooth muscle cell dedifferentiation in vitro.

154 er regeneration and possibilities to inhibit dedifferentiation in vitro.

155 r both tumor growth and maintenance of tumor dedifferentiation in vivo and uncover a common role for

156 cells is a crucial trigger for Schwann cell dedifferentiation in vivo.

157 rk-based theory for previous reports of the "dedifferentiation" in brain activity observed in aging.S

158 This dedifferentiation includes the acquisition of rapid cell

159 iant elastic matrices induced features of CM dedifferentiation, including a disorganized sarcomere ne

160 Moreover, as a result of severe dedifferentiation, including the loss of human sodium io

161 interstitial fibrosis, evident by epithelial dedifferentiation, increased myofibroblasts, immune cell

162 ells enable a variety of functions including dedifferentiation, innate immunity and adaptive immunity

163 Muller glia (MG) dedifferentiation into a cycling population of multipote

164 rafish retina, injury stimulates Muller glia dedifferentiation into a multipotent retinal progenitor

165 of the adult mouse mammary gland evokes cell dedifferentiation into a multipotent stem-like state, su

166 ach epithelial cells is sufficient to induce dedifferentiation into stem and/or multipotential progen

167 y mouse cells to show that reprogramming and dedifferentiation is a fundamental early step in maligna

168 Dedifferentiation is an important process to replenish l

169 This dedifferentiation is driven by the reactivation of gene

170 Our results suggest that age-related neural dedifferentiation is not restricted to sensory perceptio

171 This raises the question whether osteoblast dedifferentiation is specific to appendage regeneration,

172 However, whether cell dedifferentiation is the fundamental factor that trigger

173 he transcription factor network and cellular dedifferentiation likely mediate terminal liver failure

174 ocally produced TGF-beta1 can cause podocyte dedifferentiation marked by a loss of synaptopodin, neph

175 , and nkx6.1 and increased expression of the dedifferentiation markers sox2 and hes1.

176 These dedifferentiation markers were co-expressed with p-Creb

177 Oct4-mediated tumor cell dedifferentiation may have an important role during tumo

178 nomena of epigenetic assimilation and tissue dedifferentiation may help us better understand the mole

179 Thus, dedifferentiation may play a crucial role, the common mo

180 Our results suggest that dedifferentiation may play an important role in carcinog

181 The identification of pathways involved in dedifferentiation may provide clues to its reversal.

182 This age-related dedifferentiation may reflect the broadening of the tuni

183 dermal Par3 inactivation in mice promotes MC dedifferentiation, motility, and hyperplasia and, in an

184 Functionally, aged SCs exhibit impaired dedifferentiation, myelin clearance, and macrophage recr

185 loss of beta cell mass was due to beta cell dedifferentiation, not death.

186 ical role in detoxifying iron during plastid dedifferentiation occurring in embryogenesis and senesce

187 Nicotine induced dedifferentiation of acinar cells by activating AKT-ERK-

188 Loss of Numb resulted in premature dedifferentiation of acinar cells in response to injury

189 ing promotes formation of PanINs by enabling dedifferentiation of acinar cells into duct-like cells t

190 notypic switch is mechanistically similar to dedifferentiation of adipocytes as such the necdin-Wnt p

191 actor 4alpha(HNF4alpha), possibly indicating dedifferentiation of BECs.

192 betes (T2D) was recently proposed to involve dedifferentiation of beta-cells and ectopic expression o

193 n, we and others have recently proposed that dedifferentiation of beta-cells can explain the slowly p

194 l passing through a transient, nonpathologic dedifferentiation of beta-cells to a pancreatic polypept

195 vidence that sarcomatoid elements arise from dedifferentiation of carcinomatous ccRCCs and implicate

196 reticulum stress, columnar cell lesions, and dedifferentiation of CD cells with loss of aquaporin-2 a

197 conclude that OPN is an important player in dedifferentiation of cells during tumor formation, hence

198 Following dedifferentiation of chondrocytes or treatment of primar

199 rdial activation, epicardial activation, and dedifferentiation of compact myocardial cells as causati

200 ose an oncogenic module that is coopted upon dedifferentiation of early-born intermediate progenitors

201 Low shear stress induces dedifferentiation of EC through a process termed endothe

202 -lived crypt-villus "ribbons," indicative of dedifferentiation of enterocyte precursors into Lgr5(+)

203 Dedifferentiation of fibroblasts to intermediate CD34(+)

204 ture does not reflect progenitor origin, but dedifferentiation of hepatocyte-derived tumor cells.

205 g persistent HBV replication, augmenting the dedifferentiation of hepatocytes by inhibiting HNF4alpha

206 CD34(+) progenitors were generated after the dedifferentiation of human adult dermal fibroblasts by o

207 Taken together, our data show that the dedifferentiation of human dendritic cells effectively s

208 ease in type II neuroblasts results from the dedifferentiation of imINPs due to loss of Earmuff at la

209 e Brm-HDAC3-Erm repressor complex suppresses dedifferentiation of INPs back into type II neuroblasts.

210 s both the premature differentiation and the dedifferentiation of INPs by regulating the expression o

211 -specific transcription factor that prevents dedifferentiation of INPs into neuroblasts.

212 -to-mesenchymal transition (EMT) and induces dedifferentiation of LSCs, which associate closely with

213 lignant breast epithelial cells promotes the dedifferentiation of malignant breast epithelial cells i

214 Bnc1) modulates TGF-beta1-induced epithelial dedifferentiation of mammary epithelial cells.

215 n P1-transcribed mRNA, whereas Wnt3a-induced dedifferentiation of mature adipocytes produced reciproc

216 nvolving either stem cell differentiation or dedifferentiation of mature cells have been described in

217 Cancer may arise from dedifferentiation of mature cells or maturation-arrested

218 It frequently requires the dedifferentiation of mature cells to a condensed mesench

219 Moreover, loss of p53 facilitates dedifferentiation of mature hepatocytes into nestin-posi

220 Here, we show that dedifferentiation of mature osteoblasts is not restricte

221 ssion through histone modification, prevents dedifferentiation of mature somatic cells in Arabidopsis

222 nsmembrane delivery of Oct4 protein promoted dedifferentiation of melanoma cells to CSC-like cells.

223 Unlike the author's view that dedifferentiation of memory encoding processes across wa

224 examination of the CNS tumour can confirm a dedifferentiation of NEN in the direction of a neuroendo

225 precede most changes in coding genes during dedifferentiation of PHHs, and we speculated that these

226 This ability involves dedifferentiation of post-mitotic cells into progenitors

227 entry of cardiomyocytes into the cell cycle; dedifferentiation of pre-existing cardiomyocytes, which

228 n both stem cells and progenitors, including dedifferentiation of progenitor cells to a stem cell-lik

229 ession is associated with tumor progression, dedifferentiation of prostate cancer cells, and poorer p

230 RF) is thought to be a direct consequence of dedifferentiation of resident epithelial cells via an ep

231 ntal role in maintaining visual function and dedifferentiation of RPE contributes to the pathophysiol

232 In contrast, Yap knockdown prevents the dedifferentiation of secretory cells into stem cells.

233 n induced pluripotent stem cells (hiPSCs) by dedifferentiation of somatic cells offers significant po

234 us pool of pluripotent stem cells derived by dedifferentiation of stump tissue, although this has nev

235 enes and, similar to WNT3a, promoted partial dedifferentiation of the cells and the induction of a my

236 Dedifferentiation of these cells has been suggested to o

237 Brain CSC-like cells can arise from dedifferentiation of transit-amplifying progenitors upon

238 findings define a novel function for VEGF in dedifferentiation of tumor cells expanding its role in c

239 -generated hypoxia in the liver causes rapid dedifferentiation of tumor cells into immature CSCs with

240 lar injury that results in proliferation and dedifferentiation of vascular smooth muscle cells (SMCs)

241 tations of the BMP receptor gene can lead to dedifferentiation of vSMC characterized by increased mig

242 his, we mathematically modeled the effect of dedifferentiation on carcinogenesis.

243 ogenitor cell expansion without affecting MG dedifferentiation or progenitor cell generation.

244 ion of Nrg1 expression induces cardiomyocyte dedifferentiation, overt muscle hyperplasia, epicardial

245 ctopic overexpression partly phenocopies the dedifferentiation phenotype of PRC2 mutants.

246 It has recently been proposed that dedifferentiation/plasticity towards other endocrine phe

247 demonstrate a streaming hepatocyte-specific dedifferentiation process in regenerating adult human li

248 While the dedifferentiation process of mature lineages does not de

249 ial to mesenchymal transition (EMT)-mediated dedifferentiation process within 48 h, together with tra

250 he underlying mechanisms and stalling of the dedifferentiation process would be highly beneficial to

251 xpression of Snail, suggestive of an in vivo dedifferentiation process, was associated with a loss of

252 at these modulations could drive the hepatic dedifferentiation process.

253 tures seen in children, indicating a partial dedifferentiation process.

254 ic vessels that, in turn, could mediate cell dedifferentiation processes critical in vascular patholo

255 cells, demonstrating that they were a direct dedifferentiation product of mature hepatocytes.

256 c, and miR-205, which were implicated in the dedifferentiation program in HBECs and also in primary l

257 a persistent, irreversible, and multifaceted dedifferentiation program marked by EMT and the emergenc

258 uggest that AK144841 could contribute to the dedifferentiation program of tumor-forming keratinocytes

259 to-insulin' delta-cell conversion, involving dedifferentiation, proliferation and re-expression of is

260 bly of membrane attack complex promotes cell dedifferentiation, proliferation, and migration in addit

261 s ability to influence mammalian Muller cell dedifferentiation, proliferation, and neurogenesis.

262 central RNA-binding protein regulating cell dedifferentiation, proliferation, and survival, which ar

263 ts its tumorigenic effects by promoting cell dedifferentiation, proliferation, invasiveness, and diss

264 re identified as functional regulators of SC dedifferentiation/proliferation and remyelination, respe

265 ationally predicted to inhibit drivers of SC dedifferentiation/proliferation and thereby re-enforce t

266 mediate DDLPS-associated aggressiveness and dedifferentiation properties.

267 thermore, it is not known whether fibroblast dedifferentiation recapitulates the generation of multip

268 These results suggest that age-related dedifferentiation reflects distinct processes in differe

269 , we investigated its effects on acinar cell dedifferentiation, regeneration, and metaplasia.

270 types, providing a powerful system to study dedifferentiation/regeneration processes in independent

271 n that beta-cell expansion is accompanied by dedifferentiation resembling epithelial-mesenchymal tran

272 Our analysis reveals novel facets of the dedifferentiation response, including acquisition of mes

273 ion in VSMCs in non-diabetic mice results in dedifferentiation, SHPS-1 activation, and aberrant signa

274 ressing high l-caldesmon and low calponin-1 (dedifferentiation state) was maintained, whereas KCa3.1

275 ive treatments for diseases that involve RPE dedifferentiation such as proliferative vitreoretinopath

276 results in reduced beta-cell replication and dedifferentiation, suggesting that HES1 inhibition may a

277 transformation, Ad/N1ICD adipocytes undergo dedifferentiation that leads to lipodystrophy and metabo

278 In mature duct cells, Brg1 inhibits the dedifferentiation that precedes neoplastic transformatio

279 Importantly, a reduction of cAMP triggered dedifferentiation through a mechanism that required JNK,

280 ts astrocyte differentiation and can trigger dedifferentiation to a proliferative NS cell state.

281 CNS upon defined genetic alterations undergo dedifferentiation to generate a NSC or progenitor state

282 atus underlies intestinal cell diversity and dedifferentiation to restore ISC function and intestinal

283 Features of epithelial dedifferentiation towards a mesenchymal phenotype are ob

284 and provided by processes including cellular dedifferentiation, transdifferentiation, and reprogrammi

285 We propose that dedifferentiation trumps endocrine cell death in the nat

286 Their contributions to stem cell-like dedifferentiation, tumor aggressiveness, and therapy res

287 rylation in mice triggers gradual epithelium dedifferentiation, typified by reduction of RPE-characte

288 Mechanistically, Oct4-induced dedifferentiation was associated with increased expressi

289 RPE dedifferentiation was indicated by reduced pigmentation,

290 Evidence of age-related dedifferentiation was subtle at perception but more sali

291 F4, a transcription factor that induces VSMC dedifferentiation, was up-regulated in IRS-1(-/-) mice,

292 ow that tumor suppressor p53 is a barrier to dedifferentiation; whether this is strictly due to repre

293 additional factors such as inflammation and dedifferentiation, which associate with renal injury and

294 ding RNAs, in particular, miRNAs, in hepatic dedifferentiation, which can aid the development of more

295 uble cystine accumulation induces apical PTC dedifferentiation, which causes transfer of the harmful

296 sition (EMT), a process combining tumor cell dedifferentiation with acquisition of stemness features.

297 ion or inhibition of its function results in dedifferentiation with characteristics of an epithelial-

298 eceptor-gamma in adipocytes, consistent with dedifferentiation with loss of lipid and Oil Red O stain

299 un, which interconnects inflammation-induced dedifferentiation with pro-inflammatory cytokine respons

300 nscription factors KLF2 and KLF4, indicating dedifferentiation with subsequent up-regulation of PAI-1