ライフサイエンスコーパス: deep tissue

1 h bioluminescent nanocapsules, especially in deep tissue.

2 llowing for quantitative targeted imaging in deep tissue.

3 ress of bacteria from a superficial wound to deep tissue.

4 acquisition of high-resolution 3D images in deep tissue.

5 g) as a result of strong light scattering in deep tissue.

6 ed by difficulties in detecting pathogens in deep tissue.

7 ualizing and quantifying oxidative stress in deep tissue.

8 e organism in or culturing the organism from deep tissue.

9 Antares2, which offers improved signal from deep tissues.

10 are subject to scattering and absorption in deep tissues.

11 ion limits their sensitivity as reporters in deep tissues.

12 tained bacteremia, leading to the seeding of deep tissues.

13 irection in photomedicine for using light in deep tissues.

14 the brightness needed to visualize events in deep tissues.

15 teria (SFB) and increased microbial loads in deep tissues.

16 cterized by painful vaso-occlusive crises in deep tissues.

17 cell lining of the vasculature to invade the deep tissues.

18 ical high resolution fluorescence imaging in deep tissues.

19 these distortions and to focus light inside deep tissues.

20 ere the respiratory tract (40%), followed by deep tissue (30%) and superficial tissues (26%), while a

21 nduce effects at nanomolar concentrations in deep tissue and can be engineered into switchable analyt

22 therefore is particularly useful for imaging deep tissues and animals.

23 mentally overcome this resolution barrier in deep tissues and at the same time increase the focus to

24 (54.5%), followed by superficial (28.4%) and deep tissues and fluids (14.7%).

25 We compared overall, wound and skin, and deep-tissue and bone complications between brachytherapy

26 9; P < .001), but there was no difference in deep-tissue and bone complications.

27 tum yield of the polymer allows for in vivo, deep-tissue and ultrafast imaging of mouse arterial bloo

28 scent light in cells and in animals, even in deep tissues, and are suitable for multiplexed in vivo i

29 intestinal epithelium, disseminates into the deep tissues, and traverses biological barriers such as

30 y tract (58.8%), followed by superficial and deep tissues at similar frequencies (21.6 and 19.6%, res

31 r where they are located in the body-even in deep tissue beds.

32 ore effectively probed using multiparametric deep-tissue bioluminescence imaging.

33 changes of CR can be detected with skin and deep tissue biopsies.

34 agnosis of infection of a chronic wound is a deep tissue biopsy culture, which is an invasive procedu

35 To invade the deep tissues, blood-borne organisms must cross the endot

36 or mitochondria targeted PDT applications in deep tissue cancer therapy.

37 great implication in photodynamic therapy of deep-tissue cancers.

38 efore, we discuss the role of CGRP and SP in deep-tissue craniofacial pain and suggest that neuropept

39 e types of craniofacial pain, treatments for deep-tissue craniofacial pain such as temporomandibular

40 ) as a potential therapeutic target to treat deep-tissue craniofacial pain.

41 peutic potential, including the treatment of deep-tissue craniofacial pain.

42 iagnosis was confirmed by histopathology and deep tissue culture in all cases.

43 r-associated gold nanorods designed to allow deep tissue detection, therapy, and monitoring in living

44 r excitation power can be greatly reduced in deep tissues, deviating from the power requirement of ba

45 cell lining of the vasculature to invade the deep tissues during a hematogenously disseminated infect

46 etition under growth conditions that mimic a deep-tissue environment, LacD.1 conferred a significant

47 ifted fluorescent Ca2+ indicator Cal-590 for deep tissue experiments in the mouse cortex in vivo.

48 Due to the confocal pinhole, deep tissue fluorescence imaging is not practical.

49 orm with exceptional potential to facilitate deep-tissue fluorescence-based imaging for in vivo diagn

50 Modern technologies enable deep tissue focusing of nanosecond pulsed electric field

51 The reported technique provides a deep tissue-focusing solution with high efficiency, reso

52 nt for effective spirochete dissemination to deep tissues for as long as 3 weeks postinoculation and

53 P receptor protein) and cdt (colonization of deep tissues) genes have been constructed and characteri

54 watt levels of power can be transferred to a deep-tissue (>5 cm) microimplant for both complex electr

55 -II, 1000-1700 nm) is a promising method for deep-tissue high-resolution optical imaging in vivo main

56 tinociceptive effect on mechanical, cold and deep tissue hyperalagesia in both genders.

57 xicity profile that can be readily imaged in deep tissues, ICG may have significant utility for clini

58 sought to establish: (a) multimodal 2-photon deep tissue imaging and 3-dimensional analysis of the di

59 licated wavefront distortions encountered in deep tissue imaging and provide compensations for not on

60 Its deep tissue imaging capability leads to less sectioning,

61 ton excitation can be potentially useful for deep tissue imaging for future in vivo studies.

62 hniques and use of two-photon microscopy for deep tissue imaging have enabled observation of neuronal

63 lled drug delivery of large biomolecules and deep tissue imaging make this system an excellent theran

64 molecule tracking, early disease diagnosis, deep tissue imaging, and drug delivery and therapies.

65 because they offer high resolution and allow deep tissue imaging.

66 r neurons, targeted photodynamic therapy and deep tissue imaging.

67 pecificity, and some lack the capability for deep tissue imaging.

68 ous fluorophores and potentially facilitates deep tissue imaging.

69 tile nanoparticulate system for simultaneous deep-tissue imaging and drug molecule release in vivo is

70 rotein tags and components of biosensors for deep-tissue imaging and multicolour microscopy.

71 Our results set the stage for a range of deep-tissue imaging applications in biomedical research

72 optoacoustic tomography (MSOT) developed for deep-tissue imaging in humans could enable the clinical

73 Separately, orange-red FPs are useful for deep-tissue imaging in mammals owing to the relative tis

74 ity of oncolytic virotherapy, a noninvasive, deep-tissue imaging modality is needed.

75 romising applications in cellular labelling, deep-tissue imaging, assay labelling and as efficient fl

76 Red GECIs facilitate deep-tissue imaging, dual-color imaging together with GF

77 nfrared fluorescent proteins (iRFP) to allow deep-tissue imaging.

78 is the current method of choice for in vivo deep-tissue imaging.

79 n their high specificity and sensitivity and deep-tissue-imaging capability.

80 s the migration of injected DCs to small and deep tissues in mice and humans.

81 n subcutaneous mouse tissue, and 5.7-fold in deep tissues in mice.

82 d genetically encoded fluorescent probes for deep-tissue in vivo imaging.

83 We conclude that the deep tissue included in our transplants is important for

84 Penetration of light through deep tissues, including the liver and spleen, was also o

85 a organisms recovered from the intestine and deep tissues indicate local and systemic infections.

86 Efficacy was also demonstrated in the deep-tissue infection model, where Hu-1.4/1.1 bound to S

87 intoxication model, as well as in sepsis and deep-tissue infection models.

88 ted in mice in sepsis, superficial skin, and deep-tissue infection models.

89 Of the 133 wound infections, 89 (67.1%) were deep-tissue infection, occurring at a median of 8 (range

90 hylococcus aureus bacteremia associated with deep tissue infections, such as pyomyositis, osteomyelit

91 that high molecular mass HA facilitates GAS deep tissue infections, whereas the generation of short-

92 ecological tracts and less frequently causes deep tissue infections.

93 ld be standard practice in the assessment of deep-tissue infections in patients with drainage cathete

94 Most PTSAgs cause TSS in deep-tissue infections, whereas only TSS toxin 1 (TSST-1

95 icans hyphal invasion coupled with S. aureus deep tissue infiltration.

96 y organized nociceptive responses, orofacial deep tissue injury also is coupled to somatovisceral and

97 /Vc-RVM pathway is activated after orofacial deep tissue injury and plays a critical role in facilita

98 d descending pain modulation after orofacial deep tissue injury.

99 /Vc transition zone in response to orofacial deep tissue injury.

100 ulcer categorized as stages II, III, and IV; deep tissue injury; or unstageable.

101 Deep tissue intravital and organ culture microscopy stud

102 ry of previous debulking surgery, absence of deep tissue invasion, minimal residual disease after sur

103 ecific plasmids, pMT1, is thought to promote deep tissue invasion, resulting in more acute onset of s

104 Of these, 7 (44%) had deep tissue involvement.

105 nts and separately transplanted we find that deep tissue is able to induce the formation of ectopic a

106 xternal magnetic fields (less than 10 mT) in deep tissue is demonstrated for the first time.

107 ific imaging with high spatial resolution in deep tissue is often considered the grand challenge of o

108 rythema, purulent exudate, separation of the deep tissues, isolation of bacteria, and duration of inp

109 adroxil, an antibiotic, by >16-fold into the deep tissue layers of the skin without inducing skin irr

110 iplexed SERS signals in both superficial and deep tissue locations at least an order of magnitude fas

111 Current deep tissue microscopy techniques are mostly restricted

112 den was observed in the superficial skin and deep-tissue models.

113 This article presents noninvasive deep-tissue molecular images in a living subject with th

114 MRI sensor offers the exciting potential for deep-tissue monitoring of beta-cell function in vivo dur

115 ented light-scattering ambiguity inherent to deep-tissue multifocal two-photon microscopy.

116 We present a deep tissue multiplexed functional imaging method that p

117 In deep tissues, NIR BLI enabled detection of as low as 10(

118 These insights may help pave the way to deep-tissue non-invasive mapping of microvascular blood

119 is work is an important step towards in vivo deep tissue noninvasive optical imaging, optogenetics an

120 lent optical contrast and high resolution in deep-tissue observations, far beyond the penetration lim

121 enables monitoring of gene expression in the deep tissues of living subjects.

122 w for assaying PPIs both in cell culture and deep tissues of small animals.

123 transparent, presenting major challenges for deep tissue optical microscopy.

124 atter structures that are ideally suited for deep-tissue optical imaging and sensitive diagnostic app

125 ng in biomedical applications while enabling deep-tissue optical penetration, and single-molecule res

126 Melanin production also facilitated deep tissue optoacoustic imaging as well as MRI.

127 Owing to its high spatial resolution in deep tissues, PA imaging holds great potential for biome

128 esponse to an intensity-controlled sustained deep-tissue pain challenge with positron emission tomogr

129 ciency of existing PDT drug molecules in the deep-tissue-penetrable near-infrared (NIR) region has be

130 gy and pathology at the molecular level with deep tissue penetration and fine spatial resolution.

131 Further, the deep tissue penetration and high spatial and temporal re

132 ear-infrared window (1.0-1.7 mum) can afford deep tissue penetration and high spatial resolution, owi

133 The deep tissue penetration and low autofluorescence backgro

134 sing for in vivo fluorescence imaging due to deep tissue penetration and low tissue autofluorescence.

135 ypass the biological barriers, thus allowing deep tissue penetration and the accumulation of the nano

136 ectral region confer the advantage of having deep tissue penetration capacity.

137 maging owing to the low autofluorescence and deep tissue penetration in the near-infrared region beyo

138 significance of reduced autofluorescence and deep tissue penetration of light in the NIR region, the

139 Multiphoton microscopy allows for deep tissue penetration with relatively minor phototoxic

140 all size of the complex small, desirable for deep tissue penetration, and the aptamer block accessibl

141 red window (NIR-II, 1,000-1,700 nm) features deep tissue penetration, reduced tissue scattering, and

142 and be excitable by light illuminations with deep tissue penetration.

143 ric mapping of photoabsorbing molecules with deep tissue penetration.

144 IIb window) affords high spatial resolution, deep-tissue penetration, and diminished auto-fluorescenc

145 To facilitate deep-tissue photoactivation with near-infrared light, we

146 noninvasive detection of free metal ions in deep tissue remains a formidable challenge.

147 Thus, injection of capsaicin into deep tissues results in a longer-lasting mechanical allo

148 introduction of GAS into the pharynx or into deep tissues results in rapid induction of has operon ex

149 the masseter muscle, an injury of orofacial deep tissue, results in a widespread change in neuronal

150 uscle pain was shown to be effective for the deep tissue sensibility in healthy subjects.

151 ometric imaging of both cells in culture and deep-tissue small animal tumor models and validate their

152 have an increased number of primary tumors, deep tissue spread, perineural and lymphatic invasion, r

153 ng, long-term in vitro and in vivo labeling, deep tissue structure mapping and single particle invest

154 Ca(2+) at 940 nm, GCaMP3fast is suitable for deep tissue studies.

155 roducing substantially brighter signals from deep tissues than firefly luciferase and other biolumine

156 be detected with high positional accuracy in deep tissues, that molecular specificities of different

157 e changes over time, and we combined it with deep-tissue time-lapse imaging based on fast two-photon

158 lease of compounds, including potentially in deep tissue, to achieve tailored personalized therapy.

159 CRET can effectively detect MPO activity at deep tissue tumor foci due to tumor development-associat

160 h to high-resolution optical imaging through deep tissues, useful for a wide range of applications fr

161 method for multi-color, multi-RNA imaging in deep tissues using single-molecule hybridization chain r

162 ess may facilitate parasite sequestration in deep tissue vasculature.

163 ), for high-resolution imaging in centimeter-deep tissues via fluorescence contrast.

164 hypoalgesia that occurs after injection into deep tissue was reversed by spinal blockade of adenylate

165 Fluorescence imaging in deep tissue with high spatial resolution is highly desir

166 , enabled us to image fluorescent targets in deep tissue with spatial resolution beyond the acoustic

167 new opportunities for biomedical imaging of deep tissues with improved contrast.

168 howed reduced fibrosis in both cutaneous and deep tissue wounds, which was accompanied by a reduction

169 ellular infiltration in cutaneous but not in deep tissue wounds.