ライフサイエンスコーパス: deeply

1 ics to enzyme efficiency to be explored more deeply.

2 icipants engaged with text messages, thought deeply about their content and provided carefully consid

3 ur study also showed that recurrent droughts deeply affected vegetation productivity throughout the o

4 d CD4 T cells, with Irf4 and Batf deficiency deeply affecting IL-9 production.

5 flooding the vast northwestern BS shelf and deeply affecting the hydrology and circulation of the BS

6 etabolomics pattern of cod1 mutants was also deeply altered, suggesting that alternative metabolic pa

7 uggests that imbalance of dopamine signaling deeply alters hippocampal functions.

8 Observations were more deeply analyzed by flow cytometric imaging, confocal ima

9 these data point to both highly derived and deeply ancestral patterns of gene expression in skate pe

10 to probe the concept of the environment more deeply and address the perennial issue of what works for

11 lain how these aspects of our physiology are deeply and inextricably connected.

12 Certain lineages appear to branch deeply and may be part of a major phylum radiation.

13 In the deeply anesthetized mice, moderate cortical cooling was

14 Eleven deeply anesthetized swine (weight 46.2 +/- 6.2 kg).

15 We understand that this is unacceptable, and deeply apologize to Drs.

16 sociology that have not been incorporated as deeply as they might into research on healthcare systems

17 dues 1-50 is mainly alpha-helical and buried deeply at the alpha(DP)beta(DP)-catalytic interface, whe

18 temperature of maximal growth occur between deeply branching clades but thermal performance curve sh

19 increased co-metabolic interactions in more deeply branching clades.

20 strain MLFW-2, is a sporulating member of a deeply branching lineage within the order Bacillales (ph

21 man infection, we show the existence of >150 deeply branching lineages including numerous multidrug-r

22 nd extracted 29 new genomes, including three deeply branching lineages.

23 single-copy genes confirms that TM6SC1 is a deeply branching phylum.

24 e than ten branches that might represent new deeply-branching lineages of microbial eukaryotes, curre

25 Two deeply-branching mcrA clades related to Bathyarchaeota w

26 use hydrophobic access channels to reach the deeply buried active site of RoxA.

27 und flavin mononucleotide (FMN) ligands, one deeply buried and tightly bound and one more peripheral,

28 -assisted interactions can be established in deeply buried binding pockets.

29 hia coli enzyme, the final segment of CTD is deeply buried but has few specific interactions with oth

30 ible copper sites to a closed structure with deeply buried copper ions.

31 n technique for which the initial state is a deeply buried core level.

32 ppears driven by diagenetic strengthening of deeply buried fault-forming sediments, contrasting with

33 easuring forces in three dimensions, between deeply buried grains, is challenging.

34 trifluoromethyl-benzene) of the inhibitor is deeply buried in a cavity originating from the displacem

35 The 129 residue is deeply buried in the amyloid core structure, and its mut

36 , leading to a chitin-binding groove that is deeply buried in the effector protein.

37 probes offer new avenues for exploration of deeply buried infections.

38 + 3 macrocycle, and two chloride anions are deeply buried inside a folded container-shaped 4 + 4 mac

39 ch binds six sulfate anions; two of them are deeply buried inside the container structure while four

40 nomer, the ADAMTS13 cleavage site is located deeply buried inside the VWF A2 domain.

41 alpha/beta architecture, with the acyl chain deeply buried into a hydrophobic pocket that runs perpen

42 Microbial life inhabits deeply buried marine sediments, but the extent of this v

43 ntrols on the rate of POC degradation within deeply buried marine sediments.

44 distances expectedly dampen the response of deeply buried microbial communities to changes in sedime

45 terior positions in globular proteins and in deeply buried positions of membrane proteins.

46 ctural analysis reveals that Y32 is the most deeply buried residue in alpha3Y.

47 Although its biochemical activity has been deeply characterized in Xenopus, its specific relevance

48 SGRP-4X is a deeply characterized resource that provides a framework

49 One generalist phage, phi38:1, was more deeply characterized, as its infection strategy switched

50 Despite its promise for deeply characterizing mammalian proteomes, few analytica

51 ndings have elicited substantial interest in deeply characterizing the diversity, interrelationships

52 tochromism between the colorless off and the deeply colored on states when irradiated with light of 3

53 These include the existence of networks deeply committed to the cause, the potential to link wit

54 of political ideology have been found to be deeply connected to basic biological mechanisms that may

55 na, including high Tc superconductivity, are deeply connected to electron correlations on Cu and the

56 already in infancy, but is nonetheless more deeply connected to other magnitudes through adulthood t

57 The canonical genetic code is assumed to be deeply conserved across all domains of life with very fe

58 the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellul

59 he target genes that they regulate are often deeply conserved across species, the connections between

60 Our finding that enhancer activity is often deeply conserved and frequently gained provides function

61 a mechanism that regulates the activity of a deeply conserved and highly dosage-sensitive family of R

62 The co-activator complex is deeply conserved and includes the cleaved Notch intracel

63 ethyltransferase family 2, which is the most deeply conserved and widely distributed gene among metaz

64 nal mutants from our screen may reveal other deeply conserved components in fertility pathways and co

65 transferases (HPATs) are members of a small, deeply conserved family of plant-specific glycosyltransf

66 The Muscleblind (MBL) protein family is a deeply conserved family of RNA binding proteins that reg

67 e the role of dachshund (dac), a gene with a deeply conserved function in sensory organ and appendage

68 -like state in C. elegans and suggest that a deeply conserved function of sleep is to mitigate disrup

69 siological ground plans, genetic toolkits of deeply conserved genes, evolutionary changes in protein-

70 However, the existence of deeply conserved mechanisms for social behaviors has not

71 species-specific regulation of aging reveals deeply conserved mechanisms of longevity and population

72 This is a deeply conserved mode of development found in mollusks,

73 ny with amphioxus and other bilaterians, and deeply conserved non-coding sequences that are candidate

74 Neurogenesis involves deeply conserved patterning molecules, such as the prone

75 characterize one of the most evolutionarily deeply conserved receptors, IR93a, and show that it is c

76 unction for RGH3/ZRSR2 in U12 splicing and a deeply conserved role for the minor spliceosome to promo

77 ural coloration, and show that optix plays a deeply conserved role in butterfly wing pattern developm

78 , this fundamental property is governed by a deeply conserved set of 'core PCP' proteins, which inclu

79 mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key

80 stem and reveal a biological function of the deeply conserved Sox2 protein that goes beyond its well-

81 achieves universal signaling by exploiting a deeply conserved STING conformational intermediate, prov

82 As AChE is deeply conserved, widely expressed outside of the nervou

83 icitly denies non-contradiction, which seems deeply counterintuitive for the macroscopic world about

84 stresses generated by molecular motors, and deeply couples mechanics and chemistry at high spatial r

85 The graphene sheets are self-assembled and deeply crumpled into pinecone-like structure through a c

86 ive optical detector is presented based on a deeply depleted graphene-insulator-semiconducting (D(2)G

87 sistor (GFET) by carriers generated within a deeply depleted low-doped silicon substrate.

88 GluN1/GluN3 receptors produce glycine-gated deeply desensitising currents that are insensitive to gl

89 tructure, recent discoveries that unify many deeply diverged ciliate genetic systems, and a surprisin

90 complex phenotypes is within reach, even in deeply diverged species.

91 This new clade ('Snow Clade 1' or SC1) is as deeply divergent as its sister clade, the Lobulomycetale

92 with implications for tRNA processing in the deeply divergent kinetoplastid lineage and eukaryotes in

93 aphically disparate groups or a lineage more deeply diverging than that of the San contributing more

94 that the axillary bud at node 7 varied from deeply dormant to rapidly growing.

95 the use of aguitas in early child feeding is deeply embedded in Guatemalan culture.

96 pread multifunctional polarity regulators is deeply embedded in the cell cycle circuitry.

97 However, older adults deeply embedded in the complete network tend to maintain

98 d intact organism, where preBotC neurons are deeply embedded in the respiratory network, the contribu

99 as spectroscopy and lifetime measurements of deeply embedded materials, which cannot be matched using

100 One of the triflate anions is deeply embedded within the cavity of the trinuclear pill

101 As blood vessels in bone are deeply encased in the calcified matrix, imaging techniqu

102 It is a deeply engrained notion that the visual pigment rhodopsi

103 largely by accident in a career that I find deeply enjoyable and fulfilling, I hope here to convey a

104 ation (LOI) and confirmation (LOC) have been deeply evaluated.

105 ere, we reveal that the Six clusters share a deeply evolutionarily conserved 3D chromatin organizatio

106 NAs that produce peptides, including several deeply evolutionarily conserved and significantly Pi-reg

107 ith CD4 T cell depletion effectively rescued deeply exhausted CD8 T cells and enhanced antiviral cont

108 st a novel strategy for effectively rescuing deeply exhausted CD8 T cells.

109 ngle-cell whole-exome sequencing (scWES) has deeply expanded and sharpened our knowledge of cancer ev

110 In this work, we aim to deeply explore: (1) associations between microstructure

111 re by light and electron microscopy and have deeply explored the salivary transcriptome and proteome.

112 annealing effect on the photoluminescence is deeply explored.

113 We created a deeply extracted and annotated database of genome-wide a

114 ems, and electron-lucent networks penetrated deeply from the brain and nerve surfaces to form intertw

115 We show that teeth and denticles are deeply homologous developmental modules with equivalent

116 h only a cursory interest in blooms as those deeply immersed in the challenge of understanding the te

117 als as by affecting their locomotion, it can deeply impact their life-history characteristics.

118 through a series of range expansions, which deeply impacted genetic diversity in newly settled areas

119 The use of ALK inhibitors deeply impacts the therapy of patients harboring such tr

120 ce of transposition-competitive variants can deeply impair TE dynamics and gives clues to the extraor

121 Although CGIs are deeply implicated in practical analyses of DNA methylati

122 It consists of a deeply impressed cross-hatching carved into the bedrock

123 Using additional whole-genome sequence and deeply imputed data sets, we report meta-analysis result

124 eters of bone using a combination of WGS and deeply imputed genotype data, we have identified five no

125 were then meta-analysed with those from two deeply imputed GWAS replication cohorts (n = 1610 and 13

126 The additional pyridine ring of ZnTerp binds deeply in the major binding pocket and, in contrast to Z

127 hat I-CLiPs harbor their active sites buried deeply in the membrane bilayer.

128 use interactive data visualizations and read deeply in the research literature.

129 motherapeutic efficacy has not been examined deeply in whole organism models.

130 colorectum, MPP penetrated into mucus in the deeply in-folded surfaces to evenly coat the entire epit

131 l suggests that this receptor can exist in a deeply inactivated state, not responsive to ATP, and tha

132 We report here the discovery of a deeply incised canyon of the Yarlung Tsangpo River, at t

133 et of sediment-infilled depressions that are deeply incised into bedrock that we interpret as giant p

134 ical outcome was compared between women with deeply infiltrative endometriosis undergoing CO2 laser a

135 e propose that novel mtDNA-encoded genes can deeply influence bivalve sex determining systems and the

136 human CMV (HCMV) infection/reactivation can deeply influence NK cell reconstitution after umbilical

137 ng research depicts intergroup prejudices as deeply ingrained, requiring intense intervention to last

138 vesicles stabilized the formation of a novel deeply inserted conformation that does not form pores, e

139 in the interface region and is slightly more deeply inserted in 1-myristoyl-2-hydroxy-sn-glycero-3-ph

140 of insertion in PC/PG, but p3 is 1.2 A more deeply inserted than p1 in PE/PG.

141 rmation, on both local and global scales, is deeply integrated into the ventral (temporal) object-pro

142 e for conceiving of emotion and cognition as deeply integrated processes in the brain.

143 Deeply integrated with field case-based surveillance, it

144 Its functions are deeply intertwined with those of the better studied cort

145 Technology is becoming deeply interwoven into the fabric of society.

146 nosaurus rex stand out for habitually biting deeply into bones, pulverizing and digesting them.

147 e natural nucleotides, this analogue inserts deeply into hAgo2's central RNA binding cleft and thus i

148 hydrocarbon chain, and it doesn't penetrate deeply into the bilayer.

149 id headgroups and one in which it penetrates deeply into the bilayer.

150 inging a three-dimensional electronic system deeply into the EQL can be difficult however, since it r

151 NBS nanoparticles are capable of penetrating deeply into the hypoxic and acidic cores of 3D spheroid

152 The buckle was inserted deeply into the inferior fornix without suture after pne

153 the region of the protein that inserts most deeply into the lipid bilayer.

154 M's atypical amphipathic alpha-helix inserts deeply into the membrane and interacts extensively with

155 rticles; HA was apparently able to penetrate deeply into the more porous high molecular weight (684 k

156 pled to plasmonic nanocavity arrays reaching deeply into the Purcell regime with Purcell factors (F P

157 Our experiments probe deeply into the regime where theory has long predicted a

158 rganize into two long helices that penetrate deeply into the regulatory RCK domains, thus connecting

159 nd PyR2 in similar orientations, penetrating deeply into the respective domain interfaces.

160 ddition, roots tended to be distributed more deeply into the soil in canopy interspace areas.

161 vations, have enabled investigators to delve deeply into the structures that mediate episodic memory,

162 of the guest molecules were not inserted as deeply into the TPP channels as the other half.

163 led the way to cause theorists to look more deeply into this simplest of all chemical reactions.

164 The ability of X-rays to penetrate deeply into tissue and efficient ROS diffusion through u

165 HCNN approach can be used to delve even more deeply into understanding the development and organizati

166 was robust to deletion of any intergenic or deeply intronic non-coding region, indicating that proxi

167 sed on a cross-species similarity search and deeply investigate the evolution of NumtS in mammals.

168 ch as CNTs, and hence lays the foundation to deeply investigate the nonlinear mode coupling in these

169 t enantiomeric forms of amino acids has been deeply investigated because it represents the most impre

170 oward the cleavage of phosphoric diesters is deeply investigated both with kinetic experiments and DF

171 vapors into the indoor environments has been deeply investigated in the last decades.

172 ss during the cachectic process is still not deeply investigated.

173 sults demonstrate that sensory processing of deeply learned stimuli involves integrating physical sti

174 ffort is a common phenomenological construct deeply linked to volition and self-control.

175 Here we demonstrate that in deeply localized quasi-1D systems, the single dominant t

176 Central tumors and those deeply located in the right liver may require extensive

177 with HTiO2 NPs also suppressed the growth of deeply located liver tumours at least 15-fold, compared

178 ections for selected central and right-sided deeply located tumors.

179 PWV and AI are deeply modified in SCD patients in comparison with healt

180 P<0.001), whose secondary structure appeared deeply modified.

181 ierarchical organisation of human society is deeply nested in human psychology.

182 batocerebrum and Diurodrilus are found to be deeply nested members of Annelida, and unequivocal suppo

183 tions establish that glyptodonts are in fact deeply nested within the armadillo crown-group, represen

184 In addition, M. conductrix is deeply nested within the Chlorella clade, suggesting tha

185 I appreciate it deeply now, and on this meaningful occasion, I will sket

186 for major depressive disorder focuses quite deeply on glutamate function, and this research would be

187 cial skills and high ambitions to complete a deeply original study of the brainstem and spinal cord.

188 complexes are nonimmunogenic, are freely and deeply penetrant to human OA cartilage, and persist in c

189 acid chains occupy hydrophobic channels that deeply penetrate into the interior of the substrate-bind

190 cur in the minor groove, primarily through a deeply penetrating arginine residue.

191 e, with complementarity-determining region 3 deeply penetrating into the active site cleft, highly re

192 canopy to take greater advantage of the more deeply penetrating light.

193 l in overcoming this limit by using safe and deeply penetrating near-infrared (NIR) light.

194 echnology can be translated in vivo by using deeply penetrating near-infrared light for transdermal s

195 cine report Dying in America How we die is a deeply personal issue that each of us will face.

196 e risks and benefits of thrombolysis involve deeply personal values.

197 (MAGI2) through whole-exome sequencing of a deeply phenotyped cohort of patients with congenital, ch

198 -variant annotation within a large sample of deeply phenotyped individuals for gene discovery.

199 new associations in 1,685 whole genomes from deeply phenotyped individuals, we found that eSTRs are e

200 nce of individuals with catatonic signs in a deeply phenotyped schizophrenia sample (n = 1095).

201 the intravitreous injection and (2) in more deeply pigmented eyes.

202 developments, insufficient information, and deeply polarized debates about hydraulic fracturing and

203 n vitro technology has recently been used to deeply probe the DNA binding specificity of hundreds of

204 We use strand-specific RNA-seq to deeply profile lncRNAs from polyadenylated and total RNA

205 cing experiments without actually sequencing deeply, providing a basis for optimizing and comparing s

206 divinylcyclopropane rearrangements and more deeply rearranged tricyclic spirolactams resulting from

207 over, the as-produced GO can be subsequently deeply reduced (3.2 at.

208 ta suggest that U(IV) can be mobilized under deeply reducing conditions, which may contribute to main

209 It is deeply related to molecular organization, as it depends

210 Here we show that this issue is deeply related to the basic science of soft matter, espe

211 Structural variations of DNA in nuclei are deeply related with development, aging, and diseases thr

212 hese complex domain patterns are found to be deeply related with the four color theorem, stating that

213 for calling mutations from large cohorts of deeply resequenced cancer genes.

214 It is deeply rewarding to continuously let my curiosity ask qu

215 This deeply rooted cultural tradition is unlikely to be aboli

216 x system of Methanocaldococcus jannaschii--a deeply rooted hyperthermophilic methanogen growing only

217 ect on how the recent interest in lncRNAs is deeply rooted in biology's longstanding concern with the

218 Interactions with the physical world are deeply rooted in our sense of touch and depend on ensemb

219 ement learning provides a normative account, deeply rooted in psychological and neuroscientific persp

220 ta show that rudimentary multicellularity is deeply rooted in the Ascomycota.

221 urrent understanding of Arctic ecosystems is deeply rooted in the classical view of a bottom-up contr

222 n or breakdown of topological protection are deeply rooted in the intricate details of how and where

223 conflation of unrelated issues, coupled with deeply rooted misconceptions of the nature of agricultur

224 hematopoiesis has uncovered the presence of deeply rooted similarities between fish and mammals at m

225 e Pla was sufficient for the most ancestral, deeply rooted strains of Y. pestis to cause pneumonic pl

226 psychology and theory of computation are now deeply rooted.

227 owstone National Park to investigate whether deeply-rooted archaea possess and express novel mcrA gen

228 logenomic analyses place SAGMEG Archaea as a deeply rooting sister clade of the Thermococci, leading

229 gle oligonucleotide size class allowed us to deeply sample all break events.

230 tudy the terahertz light propagation through deeply-scaled graphene-based reconfigurable metasurfaces

231 Two types of deeply-scaled metacell geometries are analyzed and compa

232 From this point of view, reconfigurable deeply-scaled metamaterials can indeed provide a superio

233 am shaping applications when compared to not deeply-scaled ones; however, counterintuitively, employi

234 m thousands of kilobase-scale deletions that deeply scan across a targeted region in a tiling fashion

235 the first 7 days of an ICU stay; (4) do not deeply sedate mechanically ventilated patients without a

236 actile proteins, in mechanically ventilated, deeply sedated and/or pharmacologically paralysed intens

237 d into four levels denoted "comatose" (-5), "deeply sedated" (-4 to -3), "lightly sedated" (-2 to 0),

238 ll sedatives, volatile agents are capable of deeply sedating patients, which can have respiratory dep

239 methylome analysis of actively dividing and deeply senescent normal human epithelial cells.

240 Here we deeply sequence two sediment-hosted microbial communitie

241 We deeply sequenced 301 protein-coding genes located in 49

242 ed web server for processing and visualizing deeply sequenced data.

243 Using down-sampling of 30 deeply sequenced exomes and a set of gold-standard singl

244 Here we present genetic variation from deeply sequenced genomes of 642 individuals from North a

245 ethod, we assessed a study population of 475 deeply sequenced human genomes for genomic call rate, ge

246 enome-wide STR germline mutation rate from a deeply sequenced human pedigree.

247 genetically diverse maize inbred lines were deeply sequenced to identify genes exhibiting high and l

248 terize seven groups of novel toxins from the deeply sequenced venom gland transcriptome of S. plumipe

249 to well-characterized genomes that have been deeply sequenced with both short and long reads.

250 at unprecedented coverage and resolution by deeply sequencing locus-specific mononucleosomal DNA enr

251 digestion and DNase I digestion, followed by deeply sequencing the resulting DNA.

252 e for Drosophila cell line transcriptomes by deeply sequencing their small RNAs.

253 echanisms responsible for the release of the deeply sequestered carbon to the atmosphere at deglaciat

254 positively charged groove into which RNA is deeply sequestered, with the bases facing away from the

255 performance and survivorship of seedlings in deeply shaded tropical forests.

256 n for designing a ChIP-seq experiment is how deeply should the ChIP and the control samples be sequen

257 in Crystal Geyser (Utah, USA), a site where deeply sourced CO2 -saturated fluids are erupted at the

258 Given that deeply sourced Fe from hydrothermalism and marginal sedi

259 The persistence of deeply sourced Fe in the Pacific Ocean illustrates that

260 nce of oceanic circulation in determining if deeply sourced Fe is ever ventilated at the surface.

261 Ksar 'Akil (Lebanon), with its deeply stratified Initial (IUP) and Early (EUP) Upper Pa

262 Even pockets as tightly defined and as deeply studied as that of the muscarinic reveal opportun

263 The likely more deeply studied P. aeruginosa virulence determinant is th

264 n plant heterochromatic siRNAs have not been deeply studied, especially in wild-type plants.

265 tion in critical care survivors has not been deeply studied.

266 propagation of slow-light modes localized at deeply sub-diffractional length scales.

267 trate the imaging of a terahertz source with deeply sub-wavelength features (<30 mum) directly in its

268 Deeply sub-wavelength two-dimensional films may exhibit

269 sequent Neanderthal population was large and deeply subdivided.

270 e coherent absorption of single photons in a deeply subwavelength 50% absorber.

271 igate the implementation of this material in deeply subwavelength multimaterial nanowires, which can

272 r structure, from ambient temperature to the deeply supercooled and amorphous states, and of water di

273 nd terminates at a critical point located at deeply supercooled conditions.

274 s indicate that ice nucleated and grown from deeply supercooled liquid water is metastable stacking d

275 and a stable crystal phase exist at the same deeply supercooled thermodynamic condition, and that the

276 ulation study of halide anion solvation in a deeply supercooled water droplet (with diameter approxim

277 Understanding deeply supercooled water is key to unraveling many of wa

278 as so far prevented decisive measurements on deeply supercooled water, although this challenge has be

279 tructural crossovers for the first time in a deeply supercritical sample through diffraction measurem

280 Because red light penetrates tissue more deeply than light of shorter wavelengths, LAPD appears p

281 ss than thaw, indicating that higher Reco in deeply thawed areas during summer months was balanced by

282 Nonsummer CO2 loss in warmer, more deeply thawed soils exceeded the increases in summer GPP

283 we use next-generation sequencing to survey deeply the bacterial communities in the scent glands of

284 To explore more deeply the mechanistic similarities between different po

285 olumes of sequencing data required to sample deeply the microbial communities of complex environments

286 an genomes have been sequenced, contributing deeply to biomedical research.

287 t mud-silt substrate, projecting their claws deeply to register their traces on an underlying sand la

288 Methods to determine how deeply to sequence to achieve complete coverage or to pr

289 The capture and emission rates of deeply trapped charge carriers in the substrate-semicond

290 inequity, to achieve a brighter future for a deeply troubled region of the world.

291 We show that the deeply uncertain WAIS contribution can dominate other un

292 sea-level projections that approximates the deeply uncertain WAIS contributions.

293 We used three steps to deeply understand the drivers of such dramatic changes:

294 scription of both processes is essential for deeply understanding how riboswitches modulate gene expr

295 s of quarks and gluons inside nucleons using deeply virtual Compton scattering (DVCS)-a highly virtua

296 lantations on SOC stocks within 3-m depth in deeply weathered mineral soils.

297 e possibility that the peptides could insert deeply with minimal disruption.

298 In vivo imaging, which enables us to peer deeply within living subjects, is producing tremendous o

299 ciality is widespread, intuitive, and rooted deeply within our biological makeup.

300 structure shows that IFT52330-370 is buried deeply within the IFT70 tetratricopeptide repeat superhe