ライフサイエンスコーパス: defeat

1 ent-intruder model for social stress (social defeat).

2 inent in a subpopulation of rats that resist defeat.

3 r a purely emotional stressor termed witness defeat.

4 cur in mice with forebrain GR deletion after defeat.

5 ect was observed on other symptoms of social defeat.

6 ility in the forced swim test, as did social defeat.

7 ns mimicked the behavioral effects of social defeat.

8 ction and depression models including social defeat.

9 ased neurogenesis are consequences of social defeat.

10 status) and mice subject to repeated social defeat.

11 restoration of normal behavior after social defeat.

12 e of these molecules were affected by social defeat.

13 tating the depressive phenotype after social defeat.

14 ere susceptible, but not resilient to social defeat.

15 urogenesis and restore normal behavior after defeat.

16 on aggression were dependent on prior social defeat.

17 ovel intruder 24 hours after an acute social defeat.

18 necessary for the expression of conditioned defeat.

19 s necessary for the induction of conditioned defeat.

20 oth aggression and submission in conditioned defeat.

21 tative neural circuit underlying conditioned defeat.

22 he acquisition and expression of conditioned defeat.

23 a hamster has previously experienced social defeat.

24 did not alter the acquisition of conditioned defeat.

25 did not alter the expression of conditioned defeat.

26 iniature EPSCs (mEPSCs) in mice after social defeat.

27 ease in the frequency of mEPSCs after social defeat.

28 reased social approach in male mice naive to defeat.

29 from extremes of great victory to injury and defeat.

30 les did not experience either a victory or a defeat.

31 interaction behavior in female mice naive to defeat.

32 and female California mice exposed to social defeat.

33 c view of emotional mind/brain areas is self-defeating.

34 ling molecules in response to chronic social defeat, 2) brain reward function during social defeat an

35 reshold stress (i.e., single cycle of social defeat) 24 days after RSD, and immune and behavioral mea

36 ecently, AlphaGo became the first program to defeat a world champion in the game of Go.

37 s the first time that a computer program has defeated a human professional player in the full-sized g

38 g steepness (the probability that a dominant defeats a subordinate based on their difference in rank)

39 A and 5-HT neurons in mice exposed to social defeat, a model that induces long-lasting avoidance beha

40 The UNAIDS-Lancet Commission on Defeating AIDS-Advancing Global Health reported that the

41 0 against the previously published, champion-defeating AlphaGo.

42 Here we show that social defeat, although not producing depression by itself, pro

43 avoidance in mice exposed to chronic social defeat and concurrently prevented the electrophysiologic

44 Importantly, for both social defeat and environmental enrichment, how glucocorticoids

45 nd 3) forced swim test behavior after social defeat and fluoxetine treatment.

46 feat, 2) brain reward function during social defeat and long-term treatment with the antidepressants

47 These effects emerge after social defeat and require Oxtr specifically coupled to the extr

48 rogenesis drive changes in mood after social defeat and that glucocorticoids secreted during enrichme

49 s of mPFC gene expression changes induced by defeat, and biological pathway analysis revealed a domin

50 nulocytes in mice subject to repeated social defeat, and these effects were blocked by pharmacologic

51 Non-defeated animals receiving muscimol infusions prior to t

52 ssion and decreased submission in previously defeated animals suggesting that the LS is an important

53 des a new perspective on KP dysregulation in defeating antitumor immune responses, specifically bring

54 ution to study social affiliation and social defeat behaviors.

55 hlights the fact that previous victories and defeats both enhance aggressive behaviour in olive fruit

56 ld, null parity) vicariously experienced the defeat bout of a male conspecific, by a male CD1 aggress

57 ting increased the expression of conditioned defeat, but injection of mCPP prior to training did not

58 ining reduced the acquisition of conditioned defeat, but injection of MDL 11,939 prior to testing did

59 sed in the posterior VTA (pVTA) during acute defeat, but, with repeated defeat, CRF is recruited into

60 hallenged with a competitor that they cannot defeat by counter prediction.

61 e desired halide substitution event is often defeated by destruction of the sulfur electrophile becau

62 t specificity, with most R genes having been defeated by former pests, or do plants harbor a rich div

63 ntional pathogen virulence effector that was defeated by LOV1 and confers virulence to C. victoriae s

64 s were able to fight for longer before being defeated by the much larger robber.

65 Incompatibility is defeated by transfer of pthXo1 to otherwise xa5-incompat

66 that speak cancer's language to outsmart and defeat cancer

67 Social defeat caused a weakening of functional connectivity bet

68 The states act sequentially to defeat consecutive host barriers of the peripheral nervo

69 VTA) during acute defeat, but, with repeated defeat, CRF is recruited into the anterior VTA (aVTA) an

70 with MDD and rats exposed to chronic social defeat (CSD) stress, which is used to model depression.

71 behavior and exhibited resilience to social defeat, demonstrated by a lack of subsequent social avoi

72 explains how poxviruses can rapidly adapt to defeat different host defenses despite low mutation rate

73 The mice receiving lymphocytes from defeated donors showed less anxiety, more social behavio

74 sruption (SDR) that involves repeated social defeat during intermale aggression results in increased

75 aining, however, failed to alter conditioned defeat during testing on the following day, suggesting t

76 Plants defeat effectors with resistance proteins that guard eff

77 Our results revealed that social defeat engaged DRN GABA neurons and drove GABAergic sens

78 p, and active coping behaviors during social defeat episodes were associated with subsequent reinstat

79 re glucocorticoid receptor activation during defeat episodes.

80 igions, which began amongst pastoralists and defeated exiles, are closer to Big Gods than those assoc

81 eeking in stressed animals long after social defeat exposure.

82 ens use host fatty acids to bypass FASII and defeat FASII therapeutics.

83 , an AI that, in a 120,000-hand competition, defeated four top human specialist professionals in head

84 Viruses can evolve quickly to defeat host immune functions.

85 ion of new soybean aphid biotypes capable of defeating host-plant resistance conferred by most single

86 an increase in BDNF levels following social defeat, HR individuals did not.

87 According to the social defeat hypothesis, the long-term experience of exclusion

88 ffects on plant hormone pathways not only to defeat immunity, but also modify habitat structure, opti

89 Protection from social defeat in G-allele carriers was associated with a greate

90 investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of

91 Here we show that repeated social defeat in mice increased c-Fos staining in brain regions

92 mpared behavioral effects of repeated social defeat in mice with forebrain GR deletion and in floxed

93 Subthreshold social defeat in RSD-sensitized mice increased peripheral macro

94 ocial stressor that involves repeated social defeat in subordinate mice.

95 avioral consequences accompany victories and defeats in dyadic pairings between male Drosophila melan

96 Furthermore, social defeat increased anxiety-like behavior and caused memory

97 of microglia indicated that repeated social defeat increased levels of interleukin (IL)-1beta and re

98 Acute exposure to a third episode of defeat increased OT/c-fos colocalizations in the paraven

99 ventral bed nucleus of the stria terminalis, defeat increased Oxt messenger RNA, total OT neurons, an

100 Moreover, subthreshold social defeat increased social avoidance in RSD-sensitized mice

101 Repeated defeats induced a long-lasting loser effect that was dep

102 nvestigate the genetic mechanisms subserving defeat-induced behavioural change.

103 Defeat-induced changes in immobility in floxed GR mice w

104 facilitate the acquisition and expression of defeat-induced changes in social behavior.

105 neuronal activity is associated with social defeat-induced depression- and anxiety-like behaviors in

106 Defeat-induced gene expression of the neuronal activity

107 Repeated social defeat-induced macrophage recruitment to the brain corre

108 of Rac1 activity in the NAc increases social defeat-induced social avoidance and anhedonia in mice.

109 of the hippocampus of LR rats led to social defeat-induced social avoidance, whereas its activation

110 tic plasticity in the LS is not critical for defeat-induced suppression of aggression.

111 Social defeat induces long-lasting increases in OT production a

112 he combined data suggest that chronic social defeat induces molecular changes that reduce myelination

113 umor suppressors may provide a potent way to defeat intratumor heterogeneity.

114 prolonged binge-like access in episodically defeated intruder rats but suppressed cocaine intake by

115 Conditioned defeat is a social defeat model in Syrian hamsters in wh

116 tion of IKK signaling pathways during social defeat is both necessary and sufficient to induce synapt

117 ctively, with proactive behaviors and longer defeat latencies (LL, 52%).

118 laria Partnership's Action and Investment to defeat Malaria 2016-2030, and From Aspiration to Action:

119 The history leading to that defeat may be relevant to these future issues.

120 CSDS regimen attenuated social avoidance in defeated mice, although this effect was transient.

121 pocampal neurons compared with sham-operated defeated mice.

122 Conditioned defeat is a social defeat model in Syrian hamsters in which individuals dis

123 A robust female social defeat model is a critical first step in the identificat

124 spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory t

125 examine OT neuron activity immediately after defeat (n = 6-9) and 2 weeks (n = 6-9) and 10 weeks (n =

126 The ES mice were exposed to the social defeat of a PS mouse by a larger, more aggressive CD-1 m

127 ned acute and long-lasting effects of social defeat on OT neurons in male and female California mice.

128 fic datasets of varied types and effectively defeat one cancer patient at a time.

129 Previous defeats or victories during aggressive interactions have

130 successful, by definition, because they can defeat our immune response.

131 ons of mice undergoing a subthreshold social-defeat paradigm rapidly induced a susceptible phenotype

132 We report a new version of the social defeat paradigm that works in female mice.

133 antidepressant effects in the chronic social defeat paradigm, whereas inhibition of CaMKII activity i

134 -275, in the tail suspension test and social defeat paradigm.

135 6 mice by subjecting them to a 10-day social defeat paradigm.

136 ed resilience to repeated stress in a social defeat paradigm.

137 ion, reveals clear differences in the social defeat phenotype induced by Fosb gene manipulation in MS

138 ive amino acid substitution in K3L that also defeats PKR.

139 ency (SL) or longer latency (LL) to assume a defeat posture, respectively.

140 TA and CRF-R2 in the aVTA during each social defeat prevented escalated cocaine self-administration i

141 s, mice were subjected to the chronic social defeat procedure.

142 Repeated defeat produced alterations in forced swim and tail susp

143 We tested whether chronic social defeat produces structural alterations in the mPFC in mi

144 Social defeat profoundly and persistently decreased brain rewar

145 At the end of the social defeat protocol, body weights, food and water intake wer

146 e proteins, is likely to lead to new ways of defeating Ras-driven cancers.

147 decrease in the body weight in the socially defeated rats as compared to the controls.

148 Notably, defeated rats display enhanced learning of contextual cu

149 Socially defeated rats made significantly more errors in long ter

150 e prefrontal cortex and amygdala of socially defeated rats, when compared to control rats.

151 neural growth factor (BDNF) in episodically defeated rats, whereas the continuously subordinate rats

152 avior in subordinate, but not intermittently defeated, rats; and (3) a sensitized dopamine (DA) respo

153 In the ventral tegmental area, social defeat, regardless of susceptibility or resilience, decr

154 Despite social defeats, resilient mice with normal sociability showed n

155 o disrupt the development of the conditioned defeat response.

156 ting mechanisms of cellular physiology while defeating restriction factors that are dedicated to halt

157 In Syrian hamsters, even a single social defeat results in conditioned defeat, which includes an

158 In socially defeated rodents, a model for depression, GABABR and 14-

159 Previous work showed that repeated social defeat (RSD) in mice promoted stress-sensitization that

160 Our previous work using repeated social defeat (RSD) in mice showed that recruitment of peripher

161 Repeated social defeat (RSD) is a murine stressor that primes peripheral

162 Repeated social defeat (RSD) is a murine stressor that recapitulates key

163 In a model of repeated social defeat (RSD), elevated IL-1beta expression in the brain

164 Using a chronic social defeat (SD) stress model, learned helplessness (LH), and

165 al analysis confirmed that the 14-day social defeat sessions resulted in induction of depressive-like

166 Mice adrenalectomized before social defeat showed enhanced behavioral resiliency and increas

167 lly avoidant by the stress of chronic social defeats showed depressed neural activity in the left mPF

168 Despite Myriad's defeat, some questions concerning the rights to monopoli

169 at adult mice which underwent chronic social defeat stress (CSDS) displayed elevated anxiety-like beh

170 Exposure of Ghsr-null mice to chronic social defeat stress (CSDS) elicits more severe depressive-like

171 Chronic social defeat stress (CSDS) is a well-established rodent model

172 activity of vmPFC DBS in the chronic social defeat stress (CSDS) model of depression (n = 8-13 mice/

173 Chronic social defeat stress (CSDS) produces persistent behavioral adap

174 in NAc of mice susceptible to chronic social defeat stress (CSDS), a paradigm that produces behaviora

175 re we examined the effects of chronic social defeat stress (CSDS), an ethological form of stress, on

176 ransgenic mice that underwent chronic social defeat stress (CSDS).

177 Ac regulate susceptibility to chronic social defeat stress (CSDS).

178 ects and in mice subjected to chronic social defeat stress (CSDS).

179 roinjected into the VTA 20 min before social defeat stress (or handling) on days 1, 4, 7, and 10.

180 Repeated social defeat stress (R-SDS) reduces the expression of D1 recep

181 osure to either subthreshold repeated social defeat stress (RSDS) or a purely emotional stressor term

182 merous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechan

183 Single social defeat stress (S-SDS) induces D1 receptor-mediated extra

184 Using social defeat stress (SDS) in mice, here we identified a role o

185 leads to increased susceptibility to social defeat stress (SDS), a model of psychosocial stress, and

186 nced susceptibility to a subthreshold social defeat stress (SSDS) as observed by reduced social inter

187 We suggest that social defeat stress alters ERK1/2, IL-6, GLO1, GSR1, CAMKIV, C

188 nit knockdown decreased resilience to social defeat stress and c-fos immunoreactivity in the BLA.

189 iod increases susceptibility to adult social defeat stress and causes long-lasting transcriptional al

190 decrease in Rac1 transcription after social defeat stress and depression-related behavior, such as s

191 ind that female mice undergo repeated social defeat stress and develop social avoidance, decreased su

192 Both social defeat stress and environmental enrichment stimulate adr

193 ed mice to chronic cocaine or chronic social defeat stress and used two-photon laser scanning microsc

194 C57BL/6 mice underwent 10 days of social defeat stress and were subsequently tested for social av

195 e susceptible or resilient to chronic social defeat stress at multiple time points.

196 ranscriptional phenomena that control social defeat stress behavior.

197 Here we show that chronic social defeat stress decreases messenger RNA and protein levels

198 Intermittent social defeat stress escalates later cocaine self-administratio

199 s after CSDS or before a subthreshold social defeat stress in D1-Cre or D2-Cre bacterial artificial c

200 se neurons mediates susceptibility to social-defeat stress in freely behaving mice.

201 Here we show that repeated social defeat stress in mice activated threat appraisal centers

202 Chronic social defeat stress in mice produces a susceptible phenotype c

203 We show that chronic social defeat stress in mice produces progressive alterations i

204 Here, we show that repeated social defeat stress in rats causes persistent enhancement of l

205 type mice; and 5) exposure to chronic social defeat stress induces blood glucocorticoids and activate

206 Intermittent social defeat stress induces both locomotor and dopaminergic cr

207 Social defeat stress induces persistent cross-sensitization to

208 Chronic social defeat stress induces the formation of stubby excitatory

209 tudy we show that a single episode of social defeat stress is sufficient to specifically induce cogni

210 In a social defeat stress model of depression, depressed (susceptibl

211 In the chronic social defeat stress model of depression, we report that KCNQ-t

212 ls in plasma are reduced in a chronic social-defeat stress model of depression, which correlates with

213 Chronic social defeat stress of mice increases IkappaK activity in the

214 17, and 20, animals were subjected to social defeat stress or a nonstressful control condition follow

215 aFosB is induced in NAc after chronic social defeat stress or after chronic antidepressant treatment,

216 rate group of rats underwent a single social defeat stress or control handling and were challenged wi

217 ey rats underwent a single episode of social defeat stress or control handling, followed by amphetami

218 phocytes from mice undergoing chronic social defeat stress or from unstressed control mice were isola

219 Social defeat stress produced social avoidance (a model of depr

220 Chronic social defeat stress regulates the expression of Fosb in the nu

221 ed alcohol consumption in response to social defeat stress relative to their wild-type littermates.

222 Repeated social defeat stress resulted in repeated episodes of dramatic

223 Rac1 in the NAc of mice after chronic social defeat stress reverses depression-related behaviors and

224 epressive-like symptoms after chronic social defeat stress show distinct changes in the activity of t

225 Mice subjected to chronic social defeat stress were stratified into resilient and vulnera

226 d signals, is upregulated by repeated social-defeat stress, a highly validated mouse model of depress

227 We investigated the effect of chronic social defeat stress, a mouse model of depression, on blood-bra

228 etamine, in mice subjected to chronic social defeat stress, a validated depression model, and used RN

229 We found that chronic social defeat stress, an animal model recapitulating some aspec

230 relapse to cocaine use in rats using social defeat stress, an ethologically valid psychosocial stres

231 e present study, we show that chronic social defeat stress, an ethologically validated model of depre

232 We applied chronic social defeat stress, an ethologically validated mouse model of

233 of postmortem brain tissue, mouse models of defeat stress, and in vitro analysis, we assessed microR

234 aptic results were obtained following social defeat stress, and intracerebroventricular injection of

235 H), novelty-suppressed feeding (NSF), social defeat stress, and learned helplessness.

236 ely in susceptible mice after chronic social defeat stress, and overexpression of DeltaFosB in this r

237 CY-738 promoted resilience to chronic social defeat stress, and serotonin-selective viral overexpress

238 In a murine model of acute social defeat stress, Asb1 gene expression was significantly up

239 After chronic social defeat stress, chronic administration of imipramine sign

240 gulated in NAc of mice susceptible to social defeat stress, effects not seen in resilient mice.

241 reactivity to aversive stimuli (i.e., social defeat stress, forced swimming, and elevated plus maze)

242 Mice resilient to social defeat stress, however, exhibit stable normal firing of

243 l approaches for studying depression, social defeat stress, in particular, has been shown to have exc

244 uction of depressive-like symptoms by social defeat stress, low-novelty-seeking rats [low responders

245 After chronic social defeat stress, resilient animals displayed an upregulati

246 reased susceptibility to subthreshold social defeat stress, suggesting that neuronal VGF, expressed i

247 siological adaptations in response to social defeat stress, which are normalized by antidepressant tr

248 of cross-sensitization after a single social defeat stress, which normally produces transient cross-s

249 as one commonly used paradigm-chronic social defeat stress-has proven challenging to implement in fem

250 ling results in a reversal of chronic social defeat stress-induced social avoidance behavior.

251 ontaining MSNs of mice susceptible to social defeat stress.

252 nd mice that are resilient to chronic social defeat stress.

253 leus of vulnerable mice after chronic social defeat stress.

254 cial avoidance following subthreshold social defeat stress.

255 tor of depression-related outcomes to social defeat stress.

256 ses after mice are exposed to chronic social defeat stress.

257 depression-like phenotype induced by chronic defeat stress.

258 oral abnormalities seen after chronic social defeat stress.

259 tress using a murine model of chronic social defeat stress.

260 e ventral tegmental area (VTA) during social defeat stress.

261 ate 1 (Rac1) expression after chronic social defeat stress.

262 bitor antidepressant, fluoxetine; and social defeat stress.

263 tex (mPFC), induced susceptibility to social-defeat stress.

264 e that had been subjected to repeated social-defeat stress.

265 orphology in mice undergoing an acute social defeat stress.

266 ive-like behaviors induced by chronic social defeat stress.

267 nt of GSK3beta promoted resilience to social defeat stress.

268 translated in a mouse model of acute social defeat stress.

269 ne in NAc regulates susceptibility to social defeat stress.

270 e NAc of resilient mice after chronic social defeat stress.

271 events social avoidance after chronic social defeat stress.

272 cocaine withdrawal and after chronic social defeat stress.

273 nistration, and resilience to chronic social defeat stress.

274 n vivo recordings in mice and chronic social defeat stress.

275 II histone deacetylase, after chronic social defeat suggest a role for this enzyme in mediating depre

276 cial defeat training or prior to conditioned defeat testing.

277 cial defeat training or prior to conditioned defeat testing.

278 rticipants [43%]); (2) successful efforts to defeat the ADF mechanism leading to a continuation of in

279 ection develops, and below which neutrophils defeat the bacteria.

280 is one of the most ideal energy resources to defeat the environmental degradation caused by the consu

281 The emergence of drug resistance can defeat the successful treatment of pathogens that displa

282 winning rate against other Go programs, and defeated the human European Go champion by 5 games to 0.

283 ) that the external force on condensate bulk defeats the adhesive force between the condensate and th

284 number of processes in bacteria designed to defeat these attacks.

285 e to inspire immunologists to participate in defeating this devastating disease.

286 11,939 blocks 5-HT2A receptors during social defeat to disrupt the development of the conditioned def

287 0 mg/kg) was injected either prior to social defeat training or prior to conditioned defeat testing.

288 0 mg/kg) was injected either prior to social defeat training or prior to conditioned defeat testing.

289 in synthesis inhibitor, anisomycin, prior to defeat training, however, failed to alter conditioned de

290 ajor factor in promoting inactivation, which defeats transmission, and is allosterically coupled to p

291 ht how a zone of high rock uplift could have defeated transverse drainage networks, resulting in subs

292 eported experiencing more feelings of social defeat (U=109, z=-2.09, P=.04) and loneliness (U=87.5, z

293 g that adaptive immunity has the capacity to defeat viral escape.

294 ith the changes in BDNF expression following defeat, we report in LR animals a downregulation of the

295 how the strength-ductility trade-off can be defeated, we apply in situ, and aberration-corrected sca

296 antly reduced the acquisition of conditioned defeat when administered within the BLA.

297 related differences in behavioral effects of defeat, whereas c-fos induction in the nucleus accumbens

298 single social defeat results in conditioned defeat, which includes an abolishment of territorial agg

299 sponded to social stress passively, assuming defeat with short latencies (48%), or actively, with pro

300 ist directly into the VTA before each social defeat would prevent the development of later (1) locomo