ライフサイエンスコーパス: defective

1 -ubiquitination of Cdc20, and are checkpoint defective.

2 crophage ability to produce nitric oxide was defective.

3 the most defective and G221A being the least defective.

4 omain, which is mediated by the partitioning-defective 1 (Par1) kinases, regulates a conformational s

5 EDE1 (Endosperm DEfective 1) is homologous to AUG8 [3].

6 oot hair phenotype of the hairless root hair defective 6 (rhd6) mutant.

7 Resolution of inflammation is defective after spinal cord injury (SCI), which impairs

8 ), that were previously shown to be function defective and corrected by ivacaftor (VX-770; Kalydeco),

9 sruption of both TpnC genes resulted in jump-defective and flightless phenotypes of the survivors, as

10 ll HABP2 variants, with G221E being the most defective and G221A being the least defective.

11 even pattern of exine (upex) mutants exhibit defective and irregular exine patterns.

12 Analyses with phospho-defective and phospho-mimetic mutants of FoxM1b identifi

13 ryotic transcriptomes by degrading unneeded, defective, and potentially harmful noncoding RNAs (ncRNA

14 onarily conserved Crumbs (CRB), Partitioning-defective, and Scribble protein complexes.

15 egulator (CFTR) chloride channel, leading to defective apical chloride transport.

16 pression in Lpa1(-/-) mice further suggested defective apical junction integrity in these mice.

17 We reveal that defective ATM-mediated DNA repair is a consequence of P6

18 of endogenous DNA damage is concomitant with defective ATM-mediated DNA repair signaling and accumula

19 Defective autophagy and deranged metabolic pathways are

20 Hence, we propose that a defective autophagy could be involved in the RTT clinica

21 Plekhg5-depleted cultured motoneurons show defective axon growth and impaired autophagy of synaptic

22 Defective axonal transport is an early neuropathological

23 gnated dek38-Dsg, is embryonic lethal, has a defective basal endosperm transfer (BETL) layer, and res

24 rization that, in contrast to common wisdom, defective BaTiO3 with a large concentration of vacancies

25 emphasis onto disordered states, including 'defective by design' crystals, as well as amorphous phas

26 ostability, diminished exonuclease activity, defective catalytic activity, and compromised DNA proces

27 3 nonsynonymous ITGAM variants that produce defective CD11b associate with elevated levels of type I

28 ation stress, impaired checkpoint signaling, defective cell cycle control, and genomic instability, w

29 d-type cells leading to mitotic catastrophe, defective cell division and apoptosis.

30 cretion of nonbulky proteins, ER stress, and defective cell morphology are secondary consequences of

31 They recognize defective cells by binding to peptides presented on the

32 developmental pathways or completely remove defective cells from a population is a widespread strate

33 e entry points for fork degradation in BRCA2-defective cells.

34 egradation and chromosomal breakage in BRCA2-defective cells.

35 Mutations in KDSR cause defective ceramide biosynthesis, underscoring the import

36 Failure to complete genome replication and defective checkpoint surveillance enables BRCA2-deficien

37 Moreover, USP7 inhibition sensitized p53-defective, chemotherapy-resistant CLL cells to clinicall

38 ay have clinical benefit in diseases showing defective cholinergic transmission, such as AD.

39 We also examined the role of defective chromatin assembly in FA-mediated transcriptio

40 n defects, cell cycle progression delay, and defective chromosome segregation during anaphase.

41 e have normal cilia distribution but display defective cilia structure, including abnormal positionin

42 A key cause of plaque necrosis is defective clearance of apoptotic cells, or efferocytosis

43 Defective clearance of necrotic tissue interferes with a

44 thors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human dise

45 te translocation into the lysosome caused by defective CMA in cystinosis.

46 icted to two codons flanking the translation-defective codon.

47 A) directly repressed the MIR34A gene in p53-defective CRC cells, whereas expression of MIR34A was in

48 show impaired cross-presentation ex vivo and defective cross-priming of CD8(+) T cell responses in vi

49 uided phase retrieval algorithms for imaging defective crystals using BCDI.

50 with abundant glucose, whereas the catalysis-defective D34S aldolase mutant, which still binds FBP, b

51 Furthermore, defective DDT decreased the numbers of MPP-derived commo

52 E(z) in the germline could be attributed to defective dedifferentiation.

53 The defective degree of carbon substrate and amount of nitro

54 n of barrier disruption, mediated in part by defective desmosomes and dysregulated transforming growt

55 Cs in CD11c-Cre.Tgfbr1 (fl/fl) mice reflects defective differentiation from CD103(-)CD11b(+) intermed

56 peripheral blood indices, and corrected the defective differentiation potential of progenitors in th

57 acid oxidation alone was sufficient to cause defective differentiation, while administration of fatty

58 leads to sensitivity to DNA damaging agents, defective DNA repair and genomic instability.

59 Increased mutation burden and defective DNA repair are associated with response to imm

60 etions, and mutational signatures suggesting defective DNA repair.

61 lity in cells from patients, consistent with defective DNA replication underlying the disease phenoty

62 Mice lacking myeloid Drp1 showed defective efferocytosis and its pathologic consequences

63 l macrophages, but the mechanisms underlying defective efferocytosis and its possible links to impair

64 cular-cellular mechanism that contributes to defective efferocytosis, plaque necrosis, and impaired r

65 Genetic analyses demonstrated that the defective embryogenesis of the mpk6 mutant is a maternal

66 these seed phenotypes can be traced back to defective embryogenesis.

67 rategy for the prevention and restoration of defective enamel.

68 Those effects are due to defective engulfment and impaired LAP-mediated clearance

69 T cells, a property that was associated with defective expression of the T-cell Ig mucin (TIM)-4 rece

70 eat domains 3 (SHANK3B) scaffolding protein, defective expression of which has been implicated in ASD

71 abolic cutis laxa syndromes and further link defective extracellular matrix assembly to faulty protei

72 Defective eyelid formation correlated with profound ocul

73 ction, and advances our understanding of how defective FA signaling contributes to aging and cancer a

74 In contrast, defective farnesylation mislocalizes nascent adhesion si

75 nity of the disordering transition towards a defective fluorite structure translates into a tunable d

76 of the antioxidant N-acetylcysteine rescued defective follicle and oocyte development resulting from

77 expansion in vitro but that this process was defective following infection in vivo.

78 These mice are also defective for antitumor immune responses and are resista

79 we show that while the Ub-CR conformation is defective for conjugation, it demonstrates improved bind

80 H3-G34R mutants are defective for DNA damage repair by homologous recombinat

81 of MTBP without a functional CTM domain are defective for DNA replication in Xenopus egg extracts.

82 A genetic screen for mutants defective for GAL gene memory revealed new insights into

83 Using ZapA(N60Y), a variant defective for interaction with FtsZ, it was established

84 function through phosphorylation at S289 are defective for odor-guided behavior.

85 et the recombinant virus remained completely defective for productive replication, providing a high d

86 Yeast expressing an Rga2 mutant that is defective for regulation by calcineurin display increase

87 Cells deleted for fin are defective for spore formation and exhibit increased leve

88 We found that the Mcm10-4A mutant was defective for stimulating DDK phosphorylation of Mcm2, b

89 ) compared to that of HIV-1 Vif, and BIV Vif defective for the Pr55(Gag) interaction lost its ability

90 Defective fork stability contributes to chemotherapeutic

91 ve been isolated from RTT patients display a defective formation of autophagosomes under conditions o

92 Elevated ROS levels result in defective Foxo3(-/-) HSC cycling, among many other defic

93 d cells display impaired cell proliferation, defective G2/M arrest and increased radiochemosensitivit

94 a hydrolase domain-containing 5 (ABHD5), the defective gene in human Chanarin-Dorfman syndrome, is a

95 This is surprising, as defective gene silencing underlies developmental abnorma

96 We show that this effect is rooted in defective glycine uptake in DLBCL cell lines, rendering

97 Moreover, SIRT1 iKO mice with defective gut microbiota developed more severe colitis t

98 Similar defective hair growth was observed in kinase-inactive GK

99 (-/-) and Trp53 (-/-);Brca2 (-/-) cells have defective homologous recombination and increased sensiti

100 We recently reported a replication-defective human cytomegalovirus with restored pentameric

101 leukocytes from 3 of the patients displayed defective IFN production upon VZV infection and reduced

102 y, or between patients encoding functionally defective IFN-lambda4 (IFN-lambda4-Ser70) and those enco

103 Functional analysis revealed defective IL-2 and TNF production yet retained expressio

104 active oxygen species, closely mimicking the defective immune functions observed in beta-thalassemia

105 Defective immune system function is implicated in autism

106 g5, Atg7, or Atg16L1) but not in macrophages defective in a related, canonical autophagy pathway (Atg

107 t reported in four independent SCZ cases was defective in activating PAK3 as well as MAPK (mitogen-ac

108 and cells carrying this lethal mutation are defective in actomyosin ring assembly at the non-permiss

109 Mutants defective in AlmEF-dependent LPS modification exhibit re

110 h, we identified two Lotus japonicus mutants defective in AM-specific paralogs of lipid biosynthesis

111 These cells are defective in apoptosis owing to blocked degradation of M

112 hy, which harbour a mutation in RNF113A, are defective in ASCC foci formation and are hypersensitive

113 ng of how inflammation resolution may become defective in atherosclerosis and the potential for prore

114 lthough rings isolated from myo2-E1-Sup1 are defective in ATP-dependent contraction in vitro.

115 8G, defective in ubiquitin binding, was also defective in autophagosome formation and recruitment to

116 ing or organelle acidification but not those defective in autophagy displayed augmented APOL1 toxicit

117 igands modulated signaling of a GPR56 mutant defective in autoproteolysis and hence, in Stachel pepti

118 ALK2 mutants defective in binding FKBP12 increase hepcidin expression

119 Additional studies utilizing Ubc5BF62A, defective in binding the canonical E2 site, demonstrate

120 /Delta mutant, which is known to be severely defective in biofilm formation when grown as single spec

121 ency are restored in double mutants that are defective in both EPS production and the Frz chemosensor

122 etion of hfq, encoding an RNA chaperone, was defective in both LB and YESCA.

123 ypical hemolytic uremic syndrome (aHUS), was defective in C3bBb decay-accelerating activity (DAA) and

124 Supporting these results, E-Syt1 constructs defective in Ca(2+) binding in either C2A or C2C failed

125 t demonstrated that I2-deficient virions are defective in cell entry.

126 Mps1 inhibitor-treated oocytes are defective in centromeric cohesin protection, whereas ooc

127 We found that the luxO and aphA mutants were defective in colonization compared to levels in the wild

128 , and mice with NFATc1-deficient T cells are defective in controlling Listeria infection.

129 Activation of the MAPK Slt2p was defective in crd1Delta cells, and up-regulation of the P

130 ol-3-phosphate acyltransferase6 (gpat6), and defective in cuticular ridges (dcr) were grouped in thre

131 Macrophage intracellular pathogen killing is defective in cystic fibrosis (CF), despite abundant prod

132 e maize no perception 1 (nope1) mutant to be defective in early signalling.

133 us mpk1 seeds from heterozygous parents were defective in embryo development.

134 further found that the DeltaMoglo3 mutant is defective in endocytosis, scavenging of the reactive oxy

135 Yeast strains defective in endosomal trafficking or organelle acidific

136 In contrast, cells defective in EPS production hyper-reverse their moving d

137 esults in PSD-95 degradation and why this is defective in Fmr1 KO neurons is unknown.

138 CD4(+) T-cells from PKC-(-/-) mice were also defective in G-BMDC induced Treg proliferation ex vivo,

139 Furthermore, mutants defective in glucose uptake or dependent upon peptides f

140 Here we screen P. aeruginosa mutants defective in growth in iron-depleted media and find that

141 Further, an RPA mutant defective in H3-H4 binding exhibited attenuated nucleoso

142 s into peptide displayed by MHC I is however defective in hepatocytes lacking collectrin, an intracel

143 in the Saccharomyces cerevisiae pho2 mutant defective in high-affinity Pi transport rescues growth i

144 NA repair pathway, which is frequently found defective in human cancers.

145 Mesenchymal transitioned cells are defective in inducible interferon regulatory factor 1 (I

146 Moreover, functional study using a mutant defective in light-independent chlorophyll synthesis rev

147 hat synapses from AD brain are intrinsically defective in LTP.

148 that AD-diseased synapses are intrinsically defective in LTP.

149 lial PD-associated variants are structurally defective in membrane binding and alter the local bindin

150 cular phenotypes resembling those of mutants defective in miRNA biogenesis and activity.

151 leading to the formation of infected nodules defective in nitrogen fixation (Fix(-)).

152 Those mutant parasites that do invade are defective in nutrient import and die.

153 ization of WDR62 and mitotic progression are defective in patient-derived fibroblasts, which, similar

154 airment (MCI) and Alzheimer disease (AD) are defective in phagocytosis and degradation amyloid beta1-

155 Previous mutants were defective in PI3K because they failed to bind the enzyme

156 plex and the morphogenesis of the complex is defective in plants with reduced MpWIP function.

157 onsequently, TIPE2-deficient leukocytes were defective in polarization and chemotaxis, and TIPE2-defi

158 d association between the MCC and APC/C, are defective in poly-ubiquitination of Cdc20, and are check

159 First, PulG(T2A) variant, equally defective in PulM interaction, remained partially functi

160 Smurf1(-/-) macrophages are defective in recruiting polyubiquitin, the proteasome, t

161 that stimulates initial DNA unwinding but is defective in replication elongation and CMG binding.

162 functional as transcription factors yet are defective in replication origin timing control.

163 associated herpesvirus (KSHV) mutant that is defective in small capsid protein and is unable to produ

164 In yeast, mutants defective in sterol biosynthesis show a wide range of ch

165 ants lacking lysosome-related organelles are defective in the production of all 4'-modified ascarosid

166 press HopAI, PMIR1 -HopAI transformants were defective in the spreading of invasive hyphae and elicit

167 umber of intestinal cells, even in nematodes defective in their antiviral RNA interference (RNAi) res

168 cells type c-1 and cathepsin K expression is defective in these macrophages because of reduced Erk/c-

169 ulate carbon reserves during the day, and is defective in transcription of genes crucial for utilizat

170 a phospho-mimetic stathmin mutant (4E) made defective in tubulin binding returned cell migration and

171 A disease-associated Optn mutant, E478G, defective in ubiquitin binding, was also defective in au

172 I, II, and IV and respiratory responses were defective in vitiligo cells.

173 rning genes such as intermediate neuroblasts defective (ind).

174 erial effects, gives new significance to the defective induction of hBD2 in the barrier-defective ski

175 uli, and alphaMbeta2-deficient PMN displayed defective inflammatory functions.

176 glucose sensing are likely to contribute to defective insulin secretion in human carriers of PAX6 mu

177 beta cell mass, impaired glucose tolerance, defective insulin secretion, and increased apoptosis whe

178 Defective integrin affinity regulation in the genetic ab

179 We propose that defective intercellular adhesion contributes to uncontro

180 c tracer, or naturally occurring VSV-derived defective interfering particles (DIPs), into the caudate

181 y severe dilation of the urinary bladder and defective intestinal motility.

182 ormal bone development that is mainly due to defective intramembranous bone formation by osteoblasts.

183 ement Dsg to tag a gene that gives rise to a defective kernel (dek) phenotype.

184 osition may be influenced by coexpression of defective L1 loci and that these L1 loci may reduce accu

185 QP3-depleted colonic epithelial cells showed defective lamellipodia, focal adhesions, and repair afte

186 vivo to restore function of a polymerization-defective laminin, leading to normalized muscle structur

187 ied a hitherto unreported disease mechanism (defective linear ubiquitination) in patients with IP.

188 impaired in a male fetus with IP, leading to defective linear ubiquitination.

189 driver of the transformation of genetically defective liver stem cells (LSCs) into highly metastatic

190 Both the defective localization and the reduced levels of Ena1 co

191 argos to dynein-dynactin complexes that have defective long-range motility.

192 morphogenesis, improper lymphatic drainage, defective lymphatic valve maturation, and complete letha

193 ed to blood-filled lymphatic vessels, edema, defective lymphovenous valve morphogenesis, improper lym

194 Defective lysosomal acidification contributes to virtual

195 Unexpectedly, defective lysosomal degradation of bacteria also attenua

196 flecting vesicular transport obstruction and defective lysosomal turnover resulting from NPC1 deficie

197 antimicrobial peptide as well as evidence of defective macrophage phagocytosis (p = 0.029).

198 Proviruses with defective major splice donors (MSDs) can activate novel

199 The types of defective materials regarded in grading legislation were

200 eostasis of the brain and, furthermore, that defective MCI macrophages recover phagocytic function vi

201 ence for a unifying pathogenesis in CNMs via defective membrane trafficking and excitation-contractio

202 oss, or somatic mutations is associated with defective MHC class I expression, impaired cytotoxic T c

203 these results suggest decreased SMN leads to defective microRNA function via MEL-46 misregulation, fo

204 Defective microtubule assembly and dysregulation of KIT-

205 cytes, and imbalanced metabolism, leading to defective mineralization.

206 nuclear DNA from an egg or zygote containing defective mitochondria to a corresponding egg or zygote

207 Tregs lacking Lkb1 have defective mitochondria, compromised OXPHOS, depleted cel

208 ion-deficient beta-cells, demonstrating that defective mitochondrial dynamics solely affect substrate

209 nstressed cells but strongly accumulate upon defective mitochondrial import and impaired proteostasis

210 Defective mitophagy is thought to contribute to normal a

211 ate that T2DM aggravates HF after MI through defective mitophagy, associated exaggerated inflammasome

212 Here, we reveal a defective molecular switch in head and neck squamous cel

213 used Pcna(K164R/K164R) mice as a unique DDT-defective mouse model.

214 Our findings establish that defective MRM2 causes a MELAS-like phenotype, and sugges

215 n-rescue experiments show that a respiration-defective mutant of SOD1 is also impaired in its ability

216 s of full-length PTEN but a membrane-binding defective mutant of the C2 domain abrogated these proper

217 An interaction-defective mutant, dbf4DeltaC, phenocopies fkh alleles in

218 of the viral glycoprotein, but not a fusion defective mutant, is sufficient to cause CO2 sensitivity

219 ve and swollen state and of the transmission-defective mutant, P73G, under native conditions.

220 es, as cyclin-dependent kinase (CDK) binding-defective mutants are capable of stimulating treslin pho

221 RNA-binding-defective mutants demonstrate clear separation of functi

222 les that restored plaque formation for lysis-defective mutants of Rz and Rz1 were selected.

223 agocytic uptake in the lysosomal degradation-defective mutants via a pathway requiring cytosolic patt

224 adient, which fails to develop in elongation-defective mutants.

225 containing a synapsis-proficient, DSB repair-defective mutation in a gene (Trip13) required for remov

226 ophilic leukemia (e.g., T618I), functionally defective mutations in the extracellular domain of the G

227 Our studies indicate that the defective NEDDylation of HBx negatively affects its abil

228 for previous observations that dimerization-defective Nef mutants fail to down-regulate CD4 and vali

229 in widening of the neural plate midline and defective neural tube closure.

230 leading to infection has been confounded by defective, noninfectious particles and the stochastic mi

231 embryonic fibroblasts that recapitulate the defective nuclear organization of laminopathies, featuri

232 mislocalization and aggregation of NUPs and defective nucleocytoplasmic transport.

233 In a Notch mutant defective only in the inductive interaction, MS-derived

234 shuffling as a means to produce replication-defective or attenuated viruses.

235 py, neurons infected with VZV produced fewer defective or incomplete viral particles than MRC-5 cells

236 s a heterogeneous disorder, characterized by defective osteoclastic resorption of bone that results i

237 ve therapeutic potential even in tumors with defective p53 or ibrutinib resistance.

238 tex and biochemical activity of partitioning-defective (PAR) proteins.

239 in the NANCI-Nkx2.1 gene duplex results in a defective perinatal innate immune response, tissue damag

240 xpression of ZxAKT1 rescued the K(+) -uptake-defective phenotype of yeast strain CY162, suppressed th

241 As defective PI conversion underlies human genetic diseases

242 ant sheep, experimental models with a small, defective placenta that restricts delivery of nutrients

243 Defective platelet matrix interaction can be restored by

244 METHODS AND We observed defective PMN transmigration in response to lipopolysacc

245 an diseases called ciliopathies is caused by defective primary cilia morphology or signal transductio

246 that coordinates the destruction of folding-defective proteins in the early secretory pathway.

247 Our data give an overview of predicted defective proteins, including predicted impact scores, o

248 Defective proviruses were found to express HIV RNA at le

249 We show that HISN6B of Col-0 is not a defective pseudogene, but a stably silenced epiallele.

250 e esk1-mediated responses counterbalance the defective PTI and PcBMM susceptibility of agb1-2 plants,

251 Defective Rab11 trafficking in cystinosis was rescued by

252 Ad vaccines are engineered to be replication-defective (RD-Ad) vectors.

253 However, envelope-defective recombinant HIV-1 did not infect the renal epi

254 NOTCH1 signalling contributes to defective remyelination by impairing differentiation of

255 d currents might be the mechanism underlying defective repetitive firing.

256 d to explore potential mechanisms underlying defective repetitive firing.

257 lock RPS10 or RPS20 ubiquitylation result in defective resolution of stalled ribosomes and subsequent

258 ferocytosis and promotes plaque necrosis and defective resolution.

259 In vitro assays revealed that the defective response in Munc13-4-deficient MCs was limited

260 phied thymus by utilizing both postnatal TEC-defective (resulting from FoxN1-floxed conditional knock

261 nced when presentation was restricted to the defective ribosomal product (DRiP) form of the protein.

262 de generation reveals that ubiquitylation of defective ribosomal products is rate limiting in generat

263 es (LCLs) established from DBA patients show defective rRNA processing and ribosomal stress features

264 g zones; however these osteoclasts exhibited defective ruffled borders and were unable to resorb bone

265 ressing FANCJ pathological mutants exhibited defective SCR with an increased frequency of LTGC.

266 Our data suggest that defective self-renewal ability and leukemogenesis of MLL

267 diated expression of SIRT3 or an acetylation-defective SIRT3-K57R mutant in diet-induced obese mice d

268 Genes encoding ROOT HAIR DEFECTIVE-SIX LIKE (RSL) class I basic helix-loop-helix

269 ), an inborn error of metabolism that causes defective skeletal and dental mineralization.

270 e defective induction of hBD2 in the barrier-defective skin lesions of AD and indicates therapeutic p

271 ng of mechanisms that may be responsible for defective skin repair.

272 th significantly fewer gonocytes and exhibit defective spermatogenesis and reduced sperm count as you

273 rtheless, certain young gene mutants exhibit defective spermatogenesis and/or male sterility.

274 Moreover, defective STAT5 tetramer formation could represent a cau

275 rate Coenzyme A precursors downstream of the defective step in the pathway.

276 in each patient with HFpEF, identifying the defective steps that impair each one's exercise capacity

277 d the entire pxr gene from a developmentally defective strain that fails to remove Pxr-mediated block

278 hat SL3 is necessary for Pxr function in the defective strain.

279 vaginal challenge of C57BL/6 mice with hypha-defective strains attained high levels of mucosal coloni

280 a fusion protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deamin

281 pathogenic Htt on synaptic growth arise from defective synaptic endosomal trafficking, leading to exp

282 s that corrected the effect of a translation-defective synonymous flgM allele were restricted to two

283 ayed compromised psoriasiform phenotypes and defective T helper type 17 response.

284 d regulatory T cell differentiation but show defective Th17 differentiation in vitro.

285 s essential for proper head development, and defective TMEM107 function leads to ciliary morphology d

286 of POR as well as CHLP, which is not due to defective transcription of the POR and CHLP genes but to

287 lial localization and replication as well as defective transepithelial translocation by Salmonella In

288 trol mechanisms intervene appropriately when defective translation events occur, in order to preserve

289 Additionally, we confirm that TRE-binding-defective TRbeta leads to disruption of the hypothalamic

290 La cKO) from mouse cortex neurons results in defective tRNA processing, although the pathway(s) invol

291 tes to chemotherapeutic sensitivity of BRCA2-defective tumors by yet-elusive mechanisms.

292 ions identified thus far in association with defective ubiquitination are discussed in more detail.

293 tes a broad array of cellular processes, and defective ubiquitination is implicated in several neurol

294 se in ACSS2 in the hippocampus also leads to defective upregulation of memory-related neuronal genes

295 ompletely dominant disorder characterized by defective urinary cystine reabsorption that results in t

296 al NSCs, resulting in loss of adult NSCs and defective V-SVZ regeneration.

297 horacic duct into lymphatic tributaries with defective valves.

298 Patients with 2 defective versus 2 negative LDL receptor mutations had m

299 Replication defective viral genomes (DVGs) generated during virus re

300 -specific WNK1 (KS-WNK1), a truncated kinase-defective WNK1 isoform that is highly expressed in the D