ライフサイエンスコーパス: deficiency

1 T-cell survival (eg, vaccination and immune deficiency).

2 to infection in 3 siblings with severe G6PD deficiency.

3 fancy and arterial calcification due to CD73 deficiency.

4 le complementing enzymes in the case of APTX deficiency.

5 pression changes in LSCs caused by Tcf1/Lef1 deficiency.

6 n reduced cell viability in response to iron deficiency.

7 family member should be screened for C1-INH deficiency.

8 ant mouse models with or without adiponectin deficiency.

9 dication use and the subsequent risk of iron deficiency.

10 ctive lysosomal turnover resulting from NPC1 deficiency.

11 ed with an increased subsequent risk of iron deficiency.

12 euroendocrine features of PWS are due to PC1 deficiency.

13 edema, phenotypes associated with vitamin A deficiency.

14 s account for the clinical features of DOCK8 deficiency.

15 etardation, chronic neutropenia, and NK cell deficiency.

16 nal degeneration was similar to that of cblC deficiency.

17 ications during both erythropoiesis and iron deficiency.

18 s associated with combined pituitary hormone deficiency.

19 the same biochemical phenotype of GDP-fucose deficiency.

20 uring the initiation of colitis with miR-223 deficiency.

21 associated with early childhood respiratory deficiency.

22 cular thrombosis despite persistent ADAMTS13 deficiency.

23 he metabolic bypass of beta-hexosaminidase A deficiency.

24 ukodystrophy caused by aspartoacylase (ASPA) deficiency.

25 chondrial biogenesis is a consequence of FXN deficiency.

26 nt fractures in absence of trauma and growth deficiency.

27 gnaling pathways are restricted by the M-ILK deficiency.

28 liminated host protection conferred by Gal-1 deficiency.

29 d individuals with autosomal recessive TIRAP deficiency.

30 investigated the phenotypic effects of JAK2 deficiency.

31 e, especially that given to those at risk of deficiency.

32 -derived DCs exhibited systematic functional deficiencies.

33 inase and microtubule-associated protein Tau deficiencies.

34 of neoplastic disease with TGFbeta receptor deficiencies.

35 ning, as knockout mutants display N-fixation deficiency (25%) and increased nodular superoxide conten

36 some mutations in HCS cause holocarboxylase deficiency, a rare metabolic disorder that can be life-t

37 cy (activity = 30%-50%), and moderate-severe deficiency (activity </=30%).

38 o 3 categories: normal (activity >50%), mild deficiency (activity = 30%-50%), and moderate-severe def

39 Previously, we observed that NKG2D deficiency affects peripheral B cell numbers.

40 eviously unsuspected mechanism by which sIgM deficiency aggravates atherosclerosis.

41 Inherited or acquired ADAMTS13 deficiency allows the unrestrained growth of microthromb

42 In vitro, ISG15 deficiency also leads to persistently high levels of typ

43 Atm deficiency also markedly enhanced sensitivity to the ATR

44 GSTO1-1 deficiency ameliorates the inflammatory response stimula

45 nylketonuria (PKU, phenylalanine hydroxylase deficiency), an inborn error of metabolism, can be detec

46 nd by assessing the overlap of micronutrient deficiencies and anemia.

47 sex and results in moderate to severe mental deficiencies and decreased lifespan.

48 ets covering various stages of macronutrient deficiencies and symbiotic interactions with rhizobia an

49 These differences illuminate yield-reporting deficiencies and the value that alternative, politically

50 -/-) mice with a global MyD88, TLR7, or TLR9 deficiency and cell type-specific MyD88 deficiency to st

51 has contributed to our understanding of LOS-deficiency and compares it to studies done on Neisseria

52 h the induction of cGVHD ameliorated by BCL6 deficiency and completely suppressed by Stat3 deficiency

53 een for participants with baseline vitamin D deficiency and for secondary outcomes.

54 FX deficiency and GMDS deletion produce the same biochemica

55 ent in individuals with type II antithrombin deficiency and identified a new antithrombin functional

56 em that often results in bottom water oxygen deficiency and in turn promotes sediment phosphorus (P)

57 resequencing in patients with growth hormone deficiency and maternally inherited gingival fibromatosi

58 C1 inhibitor deficiency and patients with bowel edema only were exclu

59 ce with respiratory chain complex III (CIII) deficiency and progressive hepatopathy due to mutated BC

60 uding the heart, spleen, and liver) under Cu deficiency and that subcutaneous administration of Cu to

61 To study the relationship between Merlin deficiency and tumourigenesis, we have developed an in v

62 emperatures, UV-light, drought, and nutrient deficiencies, and may contribute to tolerance to these s

63 ations observed in patients with AT, Artemis deficiency, and SAVI.

64 is particularly marked in conditions of IL-2 deficiency, and, conversely, IL-2 represses Flicr expres

65 Although the hazards associated with iron deficiency anemia (IDA) are well known, concerns about r

66 en aged 9 to 48 months with nutritional iron-deficiency anemia, ferrous sulfate compared with iron po

67 worldwide whose inadequate diet causes iron deficiency anemia.

68 Micronutrient deficiencies are common among women in low-income and mi

69 Many efforts to prevent or treat these deficiencies are hampered by the lack of adequate, acces

70 r the T- and B-cell defects caused by LRRC8A deficiency are caused by loss of VRAC activity.

71 ssociated with succinate dehydrogenase (SDH) deficiency are characterized by high (18)F-FDG avidity.

72 Our data suggest autosomal dominant STAT4 deficiency as a novel inborn error of IL-12-dependent IF

73 survival in vitro and compensates for IL-7R deficiency, as residual ILCs are depleted in mice lackin

74 In order to address this deficiency, ASL pH was measured in vivo in children usin

75 f human growth, and show that growth hormone deficiency associated with maternally inherited gingival

76 TAX1BP1 deficiency augments virus-induced activation of proapopt

77 AND We combined a model of specific antibody deficiency, B cell-specific CD79a-Cre x XBP1 (X-box bind

78 (-/-) mice did not reflect a systemic immune deficiency, because immunized IL-1R1(-/-) mice survived

79 For SNVs, we show that MMR deficiency both increases their frequency and changes th

80 s been recognised in association with copper deficiency but has not been well characterised.

81 ortant in relation to the management of iron deficiency but should also inform dietary advice, especi

82 biochemical, and behavioral effects of 2-AG deficiency by deleting its primary synthetic enzyme, dia

83 logical and functional consequences of PLAG1 deficiency by determining testicular histology, daily sp

84 108 patients with steroid 11beta-hydroxylase deficiency CAH.

85 ronmental stressors, toxicants, and nutrient deficiencies can affect DNA in several ways.

86 TC deficiency can produce the hematologic and neurologic co

87 Clinical vitamin B12 deficiency can result in megaloblastic anemia, which res

88 NK cell deficiency can result in severe or refractory viral infe

89 HO-2 deficiency caused hyperresponsive TRAM-dependent TLR4 si

90 Regulatory T (T reg) cell deficiency causes lethal, CD4(+) T cell-driven autoimmun

91 Complement factor 3 (C3) deficiency causes prolonged bleeding, reduced thrombus i

92 ATP8A2 deficiency causes severe neurodegenerative diseases.

93 r the genetic studies of abiotic stress iron deficiency chlorosis (IDC) of soybean is reported.

94 gene expression patterns under severe OXPHOS deficiency comparing several mouse models, that will dee

95 that monogenic or digenic POLR3A and POLR3C deficiencies confer increased susceptibility to severe V

96 Thus, ENPP1 deficiency confers an energetic disadvantage to PCs for

97 ensitive to spectrin, adducin, and nucleator deficiency, consistent with microscopy-derived models pr

98 gether, these results suggest that ribosomal deficiency contributes to impaired megakaryopoiesis in m

99 e proportion of anemia with concomitant iron deficiency (defined as an inflammation-adjusted ferritin

100 mal transition and improves endothelial Fli1 deficiency-dependent vascular disintegrity, implying its

101 .Ser267Phe in SLC10A1 are prone to vitamin D deficiency, deviated sex hormones and blood lipids.

102 Muscle autophagy deficiency did not affect glucose clearance and exercise

103 Although Vps34 deficiency did not affect MK polyploidisation or proplat

104 Furthermore, CD137 deficiency did not suppress T1D development in NOD mice

105 In zebrafish, ddrgk1 deficiency disrupted craniofacial cartilage development

106 reover, it is increasingly evident that PTEN deficiency disrupts the fundamental processes of genetic

107 n, although conditions of glucagon excess or deficiency do not cause changes compatible with this vie

108 production via distinct mechanisms, as IL-4 deficiency does not prevent hyperproliferation or elevat

109 The findings suggest that CCR2 deficiency does not provide a sustained benefit and that

110 CCR2 deficiency does not provide sustained improvement of mus

111 Furthermore, neuraminidase 3 deficiency drastically increased storage of GM2 in the b

112 metal toxicant uptake and essential element deficiency during specific developmental windows increas

113 Moreover, IL-22 deficiency enhanced T cell responses to promote viral cl

114 F8 deficiency enhanced the survival of F5(L/L)Tfpi(+/-) mic

115 FXR deficiency enriched Desulfovibrionaceae, Deferribacterac

116 ant zebrafish lines, each resulting in Rbpr2 deficiency, exhibit a small eye defect, and systemic mal

117 ity and contractile responses, whereas CXCR4 deficiency favored a synthetic phenotype, the occurrence

118 patients without known risk factors for iron deficiency, gastric acid inhibitor use for >/=2 years wa

119 Growth hormone receptor deficiency (GHRD) results in short stature, enhanced ins

120 , Arabidopsis thaliana We then show that MMR deficiency greatly increases the frequency of both small

121 This deficiency hampers investigations into the biology of gl

122 Heterozygous CTLA-4 deficiency has been reported as a monogenic cause of com

123 effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different

124 Iron deficiency (ID) is common in young children aged 6-36 mo

125 rted being able to quickly correct the minor deficiencies identified.

126 ts and showed that rats with genetic IL-22BP deficiency (Il22ra2(-/-)) displayed exacerbated disease

127 CD40 deficiency impairs this process and prevents diabetic re

128 ently attenuated BMD loss caused by estrogen deficiency, improved bone turnover, promoted a favorable

129 10 papers identified all pointed out gaps or deficiencies in allergy care provision in primary care.

130 Furthermore, deficiencies in beta cell glucose sensing are likely to

131 Aging is linked to deficiencies in immune responses and increased systemic

132 singly non-redundant roles in the cell, with deficiencies in individual enzymes leading to dissimilar

133 LMT generated cellular defects that mimicked deficiencies in mitochondrial Fe-S cluster synthesis inc

134 However, until recently, deficiencies in our understanding of the nature of these

135 omal recessive disorders encompassing enzyme deficiencies in the adrenal steroidogenesis pathway that

136 ase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing.

137 Deficiencies in the PAPs resulted in perturbations of ge

138 ant isradipine plasma levels, or Cav1.3 LTCC deficiency in 6-OHDA-treated male mice.

139 The high prevalence of vitamin D deficiency in African Americans (AAs) may be a contribut

140 So far, the role of mouse Ces1/Ces1g deficiency in atherosclerosis is not elucidated.

141 these results strongly suggest that an early deficiency in beta-cell number in infants with CF may co

142 length decreases continuously, indicating a deficiency in C-strand fill-in synthesis.

143 ns including Hodgkin's lymphoma because of a deficiency in CD70, the ligand of CD27.

144 anscriptional activation in response to zinc deficiency in cells, suggesting a conserved pathway of l

145 ible deletion of CLEC-2 or platelet-specific deficiency in CLEC-2 are protected against DVT.

146 To investigate the role of BH4 deficiency in disease phenotypes, 12-month-old Fabry mic

147 ) T cells is also prevented by BCL6 or Stat3 deficiency in donor CD4(+) T cells, with the induction o

148 eficiency and completely suppressed by Stat3 deficiency in donor CD4(+) T cells.

149 25(OH)D deficiency in early childhood is associated with increas

150 CTCF deficiency in embryonic neurons is lethal in mice, but m

151 Deficiency in endothelial autophagy also increased TNF-a

152 In hypercholesterolemic mice, deficiency in endothelial autophagy increased plaque bur

153 (eg, the calculated prevalence of the severe deficiency in Europeans would be: 12.9 in 10(6)).

154 mice) blocked the protective effect of SphK2 deficiency in fibrosis.

155 (FASN) suppresses toxicity induced by PINK1 deficiency in flies, mouse cells, patient-derived fibrob

156 We find that EZH2 deficiency in FOXP3(+) T cells results in lethal multior

157 ne a type I interferonopathy due to DNase II deficiency in humans.

158 Deficiency in its homolog ARID1B is synthetically lethal

159 Our data demonstrate that Gsalpha deficiency in JG cells of adult mice results in kidney i

160 g; (ii) transcriptomic consequences of PLAG1 deficiency in knock-out and heterozygous mice compared t

161 HOIP deficiency in liver parenchymal cells triggered tumorige

162 ing: tumor testing for mismatch repair (MMR) deficiency in Lynch syndrome establishing a new paradigm

163 Such defects result in protease deficiency in lysosomes and impaired lysosomal proteolys

164 In parallel, Nlrp12 deficiency in mice caused increased basal colonic inflam

165 Genetic deficiency in mice resulted in a partially penetrant emb

166 Bmal1 deficiency in monocytes and macrophages resulted in an i

167 Here, we show that Rev1-deficiency in mouse embryo fibroblasts or mouse liver ti

168 Deficiency in pGP3 alone, which is regulated by pGP4, la

169 careers as drivers of modern economies, this deficiency in preparation for STEM careers threatens the

170 ng-term clinical implications of vitamin B-6 deficiency in stable outpatient RTRs.In a longitudinal c

171 Moreover, CCR2 deficiency in T cells promoted a program inducing the ac

172 Interestingly, NOD/SCID mice, which have a deficiency in T, B, and NK cells, showed minimal disease

173 We report that Ophn1 deficiency in the mouse generated severe cognitive impai

174 munity, we examined the impact of granzyme A deficiency in the NOD mouse model of autoimmune diabetes

175 , we found that drug treatments or a genetic deficiency in the thioredoxin system that increase level

176 ciency remains the most common micronutrient deficiency in the world.

177 The MERTK deficiency in this individual results from a nonsense va

178 LGI1 deficiency incurs a >50% down-regulation of the expressi

179 e mutant does not up- and down-regulate iron deficiency-induced and -repressed genes.

180 RNS are a nongenetic driving force for Brca2-deficiency-induced pancreatic tumors.

181 t ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by mo

182 Here we find that Cdc42 deficiency inhibits the Kras (G12D) -induced lung alveol

183 ease inhibitor used for the treatment of AAT deficiency, inhibits IBMIR and cytokine-induced inflamma

184 asizes the complex relationship between iron deficiency, iron treatment, and malaria infection in end

185 BRINDA findings confirm that iron deficiency is a common and consistent risk factor for an

186 ric and neurological disorders in which RELN deficiency is a common feature.

187 Thus, human MDA5 deficiency is a novel inborn error of innate and/or intr

188 Thus, DNAJC12 deficiency is a preventable and treatable cause of intel

189 Antithrombin deficiency is associated with increased risk of venous t

190 We found that p62 deficiency is associated with inhibited complex I mitoch

191 Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plas

192 Hereditary angioedema with C1 inhibitor deficiency is characterized by recurrent, unpredictable

193 The observed neurodegeneration in Gclc deficiency is of more chronic rather than acute nature a

194 Here we find that YTHDF2 deficiency is partially permissive in mice and results i

195 GWAS results together suggest that vitamin D deficiency is potentially causal of sero-negative RA and

196 B12 deficiency is the leading cause of megaloblastic anemia,

197 Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder in huma

198 Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red

199 is reverse activity, but the reason for this deficiency is unclear.

200 ophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by im

201 ells, but it is not fully understood how WRN deficiency leads directly to telomere dysfunction.

202 ress responses and thermogenesis, and how O2 deficiency leads to metabolic reprograming in cancer.

203 Nek7 deficiency leads to telomere aberrations, long-lasting g

204 CD11d deficiency led to a marked reduction in lipid deposition

205 Pdx1 deficiency led to decreased Atf5 transcript, and primary

206 TPL-2 deficiency led to exacerbated HDM-induced airway allergy

207 We found that Runx3 deficiency limited clonal expansion and impaired upregul

208 ximate 20% increase in the odds of vitamin D deficiency (</=20 ng/mL) [odds ratio (95% CI): 1.19 (1.0

209 evels in pregnancy and birth weight, but B12 deficiency (<148 pmol/L) was associated with a higher ri

210 (age, anthropometric measures, micronutrient deficiencies, malaria, and inflammation) and household-l

211 However, ATM deficiency markedly increases the proportion of chromoso

212 r transport protein, as well as other copper-deficiency markers are down-regulated by copper.

213 Correction of MCP1 deficiency may thus be a new therapeutic approach to SMA

214 Mismatch repair (MMR) deficiency (MMRD) and microsatellite instability (MSI) a

215 These deficiencies of mitochondrial biogenesis in FRDA cells a

216 n, primarily due to numerical and functional deficiencies of Treg cells in the periphery.

217 Deficiency of alphaMbeta2 suppressed Mvarphi egress from

218 In contrast, deficiency of alphaXbeta2 abrogated intraperitoneal recr

219 Heterozygous deficiency of APOC3 has been shown to protect against co

220 leading to combined respiratory-chain enzyme deficiency of complexes I, III, and IV.

221 ermis of psoriatic skin leading to localized deficiency of cortisol.

222 SmmhcCreER(T2)- or TaglnCre-driven)-specific deficiency of CXCR4 in an apolipoprotein E-deficient mou

223 Deficiency of factor X (F10) in humans is a rare bleedin

224 It is caused by the deficiency of glucose-6-phosphatase, an enzyme which cat

225 the wild-type protein partially rescued the deficiency of GPI-anchored proteins.

226 Deficiency of Kir2.1 channels results in elevated blood

227 ings were observed in mice with DMH-specific deficiency of melanocortin MC4R receptors, which are kno

228 , which is central for mTEC differentiation, deficiency of p53 in TECs altered multiple functional mo

229 Spinal muscular atrophy (SMA) is caused by deficiency of SMN protein, which is crucial for spliceos

230 Genetic deficiency of the CIB1 gene enhances MPTP-induced neurot

231 ls in wild-type mice and in mice with global deficiency of the Cyp27b1 gene encoding 25-hydroxyvitami

232 Conversely, conditional deficiency of the master regulator Bcl6 in CD4(+) T cell

233 In Drosophila nephrocytes, deficiency of the Pals1 ortholog caused alterations in s

234 Results showed that deficiency of the Tgr5 gene in mice alleviated fasting-i

235 It is caused by a severe deficiency of the ubiquitously expressed Survival Motor

236 CAMSA addresses the current deficiency of tools for automated comparison and analysi

237 By contrast, deficiency of TUT4 and TUT7 does not alter gene expressi

238 Because deficiency of vascular endothelial growth factor (VEGF)

239 Here we show that deficiency of Wiskott-Aldrich syndrome protein (WASp), w

240 We previously reported that in mice, deficiency of Zdhhc13, a member of the PAT family, cause

241 meric mice, we show that the impact of NKG2D deficiency on B1a cell development is cell intrinsic.

242 ls often experience, the effect of glutamine deficiency on cellular responses to DNA damage and chemo

243 te a potentially devastating impact of Disc1 deficiency on neural circuit function, partly due to Kv1

244 ls, macrophages, and fibroblasts, but IL-1R2 deficiency on neutrophils increased the IL-1-induced res

245 There was no effect of IL-1R2 deficiency on the cell-autonomous cytokine response to I

246 nt with a proproliferative effect of a GATA1 deficiency on this lineage.

247 hether L1 expression simply highlights piRNA deficiency or actually drives the germ-cell demise.

248 Correspondingly, sestrin deficiency or simultaneous inhibition of all three MAPKs

249 na) boron efflux transporter displayed boron deficiency phenotypes.

250 iants in a gene implicated in primary immune deficiency, PLCG2, and a negative regulator of inflammat

251 Significantly, TLR4 deficiency preserved the expression of CD47 (don't eat m

252 Akt2 deficiency profoundly inhibited the development of liver

253 Both PXR activation and deficiency promote hepatic triglyceride accumulation, a

254 BCL9L deficiency promoted tolerance of chromosome missegregati

255 SIRT3 deficiency promotes lung fibrosis by augmenting alveolar

256 ed levels of C16-ceramide, showed that CerS6-deficiency protected against the development of colitis.

257 ue to environmental insult or innate genetic deficiency, protein folding environments of the mitochon

258 , health outcomes resulting from nutritional deficiencies, quality of life, mortality, and harms of s

259 Conversely, TDP-43 deficiency reduced the population of processing intermed

260 This suggests that alpha-actinin-3 deficiency reduces muscle performance at baseline, but a

261 Whether ANGPTL3 deficiency reduces risk of coronary artery disease (CAD)

262 with fetal abnormalities and cerebral folate deficiency-related developmental disorders.

263 Despite its known detrimental effects, iron deficiency remains the most common micronutrient deficie

264 P2X7 deficiency resolved plaque inflammation by inhibition of

265 were not or only slightly affected by Cox4i2 deficiency, respectively.

266 romoter analysis revealed the presence of Zn-deficiency-response elements (ZDREs) in a number of the

267 TEC-specific Irf4 deficiency resulted in a significantly reduced thymic Tr

268 Ch25h deficiency results in cholesterol-dependent reduced mito

269 25(OH)D3 deficiency results in failure in bone formation and skel

270 The 3 individuals with complete ANGPTL3 deficiency showed no evidence of coronary atheroscleroti

271 olated renal tubules revealed that this Xpr1 deficiency significantly affected Pi efflux.

272 ving the replication stress induced by FANCM deficiency, simultaneous depletion of BLM and FANCM, or

273 Vitamin A deficiency strongly predicted the risk of incident tuber

274 sly reported that CD137 (encoded by Tnfrsf9) deficiency suppressed type 1 diabetes (T1D) progression

275 hepcidin suppression by erythropoietin, iron deficiency, thalassemia, and hemochromatosis.

276 Unlike CAH caused by 21-hydroxylase deficiency, the disease is far more common in the Middle

277 TLR9 deficiency and cell type-specific MyD88 deficiency to study the functional correlation between M

278 The Primary Immune Deficiency Treatment Consortium (PIDTC) is enrolling chi

279 At the molecular levels, hepatic Foxo1/3/4 deficiency triggered a significant increase in the expre

280 bling, potentially fatal condition caused by deficiency (type I) or dysfunction (type II) of the C1 i

281 Combined TIRAP and anti-LTA Ab deficiencies underlie staphylococcal disease in this pat

282 Patients with unilateral abdominal wall deficiency, unilateral undescended testis and female neo

283 and a potential tool for fighting vitamin A deficiency (VAD) in developing countries.

284 ic patients with stage 3-4 CKD and vitamin D deficiency, vitamin D supplementation may improve vascul

285 TLR4 deficiency was also associated with reduced inflammation

286 Stard7 deficiency was associated with altered mitochondrial siz

287 Vitamin B-6 deficiency was defined as PLP <20 nmol/L, and insufficie

288 At 8 months, the risk for iron deficiency was reduced in the delayed clamping group in

289 he Fabry mice receiving SRT but not ERT, BH4 deficiency was restored, concomitant with ameliorated ca

290 In a murine model of lymphoid-specific EZH2 deficiency we found that EZH2 was required for proper de

291 arious serum sources with defined complement deficiencies, we demonstrate that, under physiologic con

292 To address this deficiency, we present RolyPoly, a regression-based poly

293 To understand and ultimately correct this deficiency, we quantified flavor-associated chemicals in

294 Blood samples of 3 patients with severe G6PD deficiency were analyzed for G6PD enzyme activity, cellu

295 cTFH cells in patients with LRBA deficiency were biased toward a TH1-like cell phenotype,

296 SIRT5(-/-) mice, like humans with Complex II deficiency, were found to have mild lactic acidosis.

297 us treatment and germline replication repair deficiency, which improved management of patients and fa

298 icipated outcome of homologous recombination deficiency, which triggers cell lethality and, we propos

299 a monogenic cause of common variable immune deficiency with features of immune dysregulation.

300 identified Insulin-like growth factor (IGF1) deficiency with inadequate compensation by Growth hormon