ライフサイエンスコーパス: deficient

1 hat 1 in every 600 Caucasian children is IgA deficient.

2 th 1270 participants (24.9%) being vitamin D deficient.

3 mational conversion of "open" mitotic arrest deficient 2 (O-MAD2) into "closed" MAD2 (C-MAD2).

4 uced in wild-type (WT) and ubiquitin-binding deficient ABIN1[D485N] mice, and renal pathophysiology a

5 Fabry disease is caused by deficient activity of alpha-galactosidase A and subseque

6 espan of ZIKV-infected interferon signalling-deficient AG129 mice.

7 fects of tPA were ameliorated in PPK (Klkb1)-deficient and FXII-deficient mice and in wild-type (WT)

8 ogression to heart failure in both vitamin D deficient and normal mice without inducing significant h

9 s for the selective halogenation of electron-deficient and strained aliphatic molecules is rare.

10 entiate cocaine-primed reinstatement in OCT3-deficient and wild-type mice.

11 By using both IL-10-deficient and wild-type mothers, we showed that both ino

12 TLR2-, TLR4-, MyD88-deficient and WT BALB/c mice were intratracheally challe

13 mic profiling to identify genes enabling BLM-deficient and/or cytidine deaminase-deficient cells to t

14 tation of apoptotic cells, DC-specific Vps34-deficient animals developed increased metastases in resp

15 cytometric analysis of lung tissue from H2 R-deficient animals revealed increased numbers of CD1d(+)

16 effects on atherogenesis in apolipoprotein E-deficient (ApoE(-/-)) mice.

17 port, we present unique examples of electron-deficient arenes instead undergoing preferential substit

18 for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylme

19 Here we report that Atf3-deficient (Atf3(-/-)) mice developed spontaneous tumors,

20 In vitro, IL4I1-deficient B cells proliferate more efficiently than thei

21 n of premature cellular senescence in an NF1-deficient background.

22 Employing an electron deficient beta-diketiminato copper(II) nitrito complex [

23 Deltalsr2; it does not rescue the maturation-deficient biofilms of a DeltagroEL1 mutant, thereby diff

24 ay exert beneficial effects against estrogen-deficient bone loss.

25 Reducing NAPRT levels in a BRCA2-deficient cancer cell line exacerbated DNA damage in res

26 r loss of p53 and that targeting Mdm2 in p53-deficient cancers has therapeutic potential.

27 ion of mutant neoantigens in mismatch repair-deficient cancers make them sensitive to immune checkpoi

28 a putative synthetic-essential gene in PTEN-deficient cancers.

29 ors represent potential therapeutics for VHL-deficient CC-RCC.

30 The adoptive transfer of HDM-pulsed LRP-1-deficient CD11b(+) DCs into WT mice generated a similar

31 The use of A2aR-deficient CD4 T cells established that this CGS effect w

32 e consistently dephosphorylated in both Rheb-deficient CD4(+) T cells and T cells treated with rapamy

33 Investigations into the DOCK8-deficient CD4(+) T cells provided an explanation for som

34 estigate the phenotype and function of DOCK8-deficient CD4(+) T cells to determine (1) intrinsic and

35 nalyzing activated murine wild-type and Rheb-deficient CD4(+) T cells, as well as murine CD4(+) T cel

36 R-155 targets in tumor-infiltrating, miR-155-deficient CD8(+) T cells, suggesting that miR-155 and IC

37 the acquisition of effector function in ITK-deficient CD8(+) T cells.

38 ction by naive wild type and tristetraprolin-deficient CD8(+) T-cells is comparable.

39 and lack of TCR signaling restoration in LAT-deficient cell lines reconstituted with a synthetic LAT

40 onfirmed diminished neurogenesis in the MCT8-deficient cell population as well as aberrant migration

41 s3 encoding galectin-3 was increased in Tsc2-deficient cells and serum of Tsc2cKO(Prrx1)-cre mice.

42 dispensable, with all stress defects of Sty1-deficient cells being suppressed by expression of the At

43 MRE11 is highly unstable in PTEN-deficient cells but stability can be significantly resto

44 CL-deficient cells exhibited decreased GFP-tagged mitochond

45 We found that RAD51D-deficient cells had a reduced capacity for HR-mediated g

46 We showed previously that Trex1-deficient cells have reduced mammalian target of rapamyc

47 viral glycoproteins fail to mature in SPCA1-deficient cells preventing viral spread, which is eviden

48 However, ULK1-deficient cells responded normally to DMXAA, indicating

49 ling BLM-deficient and/or cytidine deaminase-deficient cells to tolerate constitutive DNA damage and

50 ding Cul3(KLHL9/KLHL13), was intact in SCCRO-deficient cells, suggesting that SCCRO selectively, rath

51 and cadC are substantially increased in Tdg-deficient cells, those of both AP- and betaE-sites are u

52 ed replication of C. trachomatis even in p53-deficient cells.

53 ws activation of cell signaling events of HS-deficient cells.

54 cellular mechanism, and selectivity for MMR-deficient cells.

55 to Wipi2-positive puncta are reduced in Optn-deficient cells.

56 on of DNA in the cytoplasm of AT and Artemis-deficient cells.

57 lls, but only reduced proliferation in Nupr1-deficient cells.

58 transfer from F(-) anions to the pi-electron-deficient ClBDPPV through anion-pi electronic interactio

59 The fibrotic response in Clusterin deficient (CLU-/-) mice persisted after bleomycin and it

60 specimens from DMD, Ullrich CMD, and merosin-deficient CMD patients, all of which present high levels

61 utation profiles observed in mismatch repair-deficient colorectal cancers.

62 Merosin-deficient congenital muscular dystrophy type 1A (MDC1A)

63 entirely blocked at an early stage in Flower-deficient CTLs and is rescued to wild-type level by rein

64 nsoni eggs do not develop in mice with IRF-4-deficient DCs (IRF-4(f/f) CD11c-cre).

65 of Jagged 1 and Jagged 2 single- and double-deficient DCs to induce AAI.

66 t-7c were introduced into otherwise microRNA-deficient Dgcr8 knockout mouse embryonic stem cells.

67 DN in wild-type (DGKalpha(+/+)) and DGKalpha-deficient (DGKalpha(-/-)) mice in which diabetes was ind

68 n with wild-type, but not enzyme-active site-deficient DHHC3.

69 how for 4 weeks or a methionine- and choline-deficient diet for 1, 4, 8, or 12 weeks to induce a cont

70 inhibitor AZD5363 induced apoptosis in PTEN-deficient DLBCLs irrespective of their molecular subtype

71 /6 donors but not from MHC class II- or CD40-deficient donors.

72 In addition, jagn-deficient embryos display defects in apical-basal spindl

73 found that cleft palate pathogenesis in Pax9-deficient embryos is accompanied by significantly reduce

74 ce of callous-unemotional (CU) traits (e.g., deficient emotional reactivity, callousness) in conduct-

75 Glycan-deficient Env derivatives can be used as priming immunog

76 Leukotriene C4 synthase-deficient eosinophils exhibited impaired chemotaxis to C

77 hropoiesis.sTfR may be useful to assess iron-deficient erythropoiesis, but inflammation influences it

78 ntly change the estimated prevalence of iron-deficient erythropoiesis.sTfR may be useful to assess ir

79 ETB deficient (ETB def) or transgenic control (TG-con) rats

80 ed by Drp1 deletion, and is observed in Drp1-deficient fibroblasts.

81 on is increased in B-lineage cells from Gli3-deficient FL and showed that these cells expressed reduc

82 euroanatomical changes in the brains of mice deficient for a gene in the minimal critical deletion re

83 o and in vivo assays, we show that monocytes deficient for TNF or TNF receptors are outcompeted by th

84 mutagenesis and skin carcinogenesis in IGF-1-deficient geriatric skin may be caused by defects in mul

85 NADPH oxidase-deficient (gp91(phox) knockout [KO]), iNOS-deficient (iN

86 initial adsorption of water via the electron-deficient H atom and the subsequent dissociation of the

87 ric epithelial cells with wild-type and VacA-deficient H. pylori strains, treatment of cells with pur

88 also enhanced transduction of the FX binding-deficient HAdV-5HVR5*HVR7*E451Q (AdT*).

89 ctopically express wild-type and NEDDylation-deficient HBx and found that NEDDylation-deficient HBx s

90 tion sites and observed that the NEDDylation-deficient HBx has shorter half-life.

91 ion-deficient HBx and found that NEDDylation-deficient HBx showed less chromatin localization and les

92 rotected sarcomeres from degradation in ncx1-deficient hearts.

93 in viral replication upon infection with Vpr-deficient HIV-1.

94 rentiation, and reduced splenomegaly of iron-deficient Hri(-/-) and eAA mice.

95 gene 1 (ETS1) is overexpressed in these FLI1-deficient iMegs, suggesting FLI1 negatively regulates ET

96 remodeling, which involves the INFLORESCENCE DEFICIENT IN ABSCISSION (IDA)-derived peptide and its re

97 Here, we have demonstrated that mice deficient in C-type lectin family 14 member A (CLEC14A)

98 We show that the gastrointestinal tract is deficient in de novo generation of Treg cells in allergi

99 Consequently, hearts of mice deficient in either GM-CSF or its receptor recruit fewer

100 Islets deficient in GATA6 activity display decreased insulin co

101 C57BL/6 mice deficient in GM-CSF are resistant to EAE induced by immu

102 mice, IL33-/- mice, B6.C3(Cg)-Rorasg/sg mice deficient in group 2 innate lymphoid cells (ILC2), and C

103 link with these disorders, confirm that dogs deficient in HACD1 are relevant models, and strengthen t

104 at is absent in SMG cells isolated from mice deficient in P2X7Rs (P2X7R(-/-)).

105 induced by DNFB gavage in germ-free and mice deficient in several TLRs.

106 ound that mutation accumulation in organoids deficient in the mismatch repair gene MLH1 is driven by

107 d polyclonal cancer antigen-reactive T cells deficient in the regulator diacylglycerol kinase zeta (D

108 of the denitrification respirome in strains deficient in the transcription factors FnrP, Nnr and Nar

109 lved in the final step of heme synthesis, is deficient in these patients.

110 and restriction, KS-WNK1 knockout mice were deficient in these structures under identical conditions

111 Q and E152K to rescue the phenotype of yeast deficient in Vms1, the yeast homologue of ANKZF1.

112 V-LUJV infection, and cells lacking NRP2 are deficient in wild-type LUJV infection.

113 e-deficient (gp91(phox) knockout [KO]), iNOS-deficient (iNOS KO), and C57BL/6 wild-type mice were ora

114 into the mechanisms of progression of Tgfbr2-deficient invasive transition zone squamous cell carcino

115 )/LacZ mice had impaired regeneration of MET-deficient ISCs.

116 ion-related genes NLRP3 and IL-1beta in Nrf2-deficient kidneys after UUO.

117 d properties, in the life cycle of cell wall-deficient L-form bacteria.

118 ECs from LAL-deficient (lal(-/-)) mice possess enhanced proliferation

119 in ribonucleic acid or expression of phospho-deficient LDHA Y10F sensitized the cancer cells to anoik

120 rosis-prone low-density lipoprotein receptor deficient (Ldlr(-/-)) mice.

121 Western diet-fed LDL receptor-deficient (Ldlr-/-) mice with myeloid-specific deletion

122 jections are significantly reduced in leptin deficient (Lep(ob/ob) ) mice and this phenotype is large

123 Consequently, TIPE2-deficient leukocytes were defective in polarization and

124 Metabolomics analysis of ACC-deficient liver identifies a marked increase in antioxid

125 kinetic profile and efficacy in a human PTEN-deficient LNCaP prostate carcinoma xenograft tumor model

126 follicular CCL21 gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream.

127 Hdac8-deficient LT-HSCs displayed hyperactivation of p53 and i

128 he effect of GDH1 on AMPK is evident in LKB1-deficient lung cancer, where AMPK activation predominant

129 ators CamkII and Stat1 was impaired in Trpc3-deficient M1 cells, gathering insight about other molecu

130 CD11d-deficient M1 macrophages demonstrated improved migration

131 TET2-deficient macrophages exhibited an increase in NLRP3 inf

132 P2X7-competent and P2X7-deficient macrophages were isolated and stimulated with

133 tro functional study demonstrated that NFAT5-deficient macrophages were more susceptible to apoptotic

134 d with marked metabolic changes in the Irgm1-deficient macrophages, including increased glycolysis an

135 metastases was both strongly inhibited in C3-deficient mice (C3(-/-) mice), with tumors undetectable

136 poietic progenitor cells engrafted in immune deficient mice (huNSG) results in viral latency that can

137 Here, we report that constitutive Twf2a-deficient mice (Twf2a(-/-)) display mild macrothrombocyt

138 is accelerated, not only in tristetraprolin-deficient mice after cytotoxic T lymphocyte depletion, b

139 ects type I or type I/II interferon receptor-deficient mice against lethal ZIKV challenge.

140 To address this question, we generated Cic-deficient mice and human oligodendroglioma cell models.

141 meliorated in PPK (Klkb1)-deficient and FXII-deficient mice and in wild-type (WT) mice pretreated wit

142 ed disease onset, prolonged life span of Tk2-deficient mice and restored mtDNA copy number as well as

143 other than Vip, yet activity rhythms in Lhx1-deficient mice are similar to Vip(-/-) mice under light-

144 imary mouse B cells from wild-type and STAT6-deficient mice cultured for 4 d in the presence or absen

145 gammadelta-T-cell-deficient mice developed profound RPE and retinal damage

146 In contrast, RBPJkappa-deficient mice did not experience AAI and airway hyperre

147 MET-deficient mice did not have defects in intestinal homeos

148 rates however that both ActRIIB- and ActRIIA-deficient mice display a hypertrophic phenotype.

149 eported here, we found that uninfected Irgm1-deficient mice displayed high levels of serum cytokines

150 Moreover, miR-146a-deficient mice do not resolve inflammation after discont

151 AMCase-deficient mice exhibit premature morbidity and mortality

152 On the other hand, the Igf1r-deficient mice exhibited no AHR, and a selective decreas

153 regulate myelin thickness, we examined FGFR2-deficient mice for the expression of key signaling molec

154 We showed that JNK1-deficient mice had a significantly higher survival rate

155 Folate deficient mice had lower serum folate (-60%).

156 In contrast to C3(-/-) mice, C5-deficient mice had no apparent defect in platelet activa

157 We report that CCRL2-deficient mice have a defect in neutrophil recruitment a

158 Studies that used splenocytes from GPR120-deficient mice have confirmed this conclusion.

159 In agreement, Cry-deficient mice have reduced body ( approximately 30% red

160 myeloid progenitors from NFI-A myeloid cell-deficient mice impeded myeloid cell maturation and promo

161 IgG transfer in IgG-deficient mice implicated IgG as the pathogenetic ligand

162 utor to excessive inflammation seen in Irgm1-deficient mice in different contexts.

163 , prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clea

164 As a consequence, PNPLA1-deficient mice lacked a functional corneocyte-bound lipi

165 Melanomas in PP;Trp53-deficient mice lacked either Ras or Braf mutations, and

166 s in synaptic function and plasticity in DBN deficient mice may indicate robust compensatory mechanis

167 Phf8 deficient mice neither display obvious developmental def

168 We analyzed alphaII spectrin-deficient mice of both sexes and found that loss of alph

169 As a result, NKG2D-deficient mice produce significantly less Ag-specific Ig

170 Wild-type (WT) and B cell-deficient mice received ovalbumin (OVA) intranasally bef

171 s administration of recombinant CCL5 to C3aR-deficient mice rescues the defects in inflammatory cell

172 e serial transplantation assays using Zfp521-deficient mice revealed that ZFP521 regulates HSC self-r

173 In contrast, GSTO1-1 deficient mice show a more severe inflammatory response

174 ethality in infected animals, whereas B cell-deficient mice showed CD4(+) T cell loss but recovered f

175 Importantly, Pfn2-deficient mice showed iron accumulation in discrete area

176 inflammation was marginally reduced in ILC2-deficient mice that received combined DEP+HDM, it was ab

177 aluminum hydroxide can be achieved in Foxp3-deficient mice using nondepleting anti-CD4 Abs.

178 hy subjects caused insulin resistance in IgG-deficient mice via FcgammaRIIB, indicating that similar

179 nd antisteatotic effects observed in ZFP36L1-deficient mice were accompanied by impaired lipid absorp

180 ze and insulin content in pancreata of A2AAR-deficient mice were decreased compared with control mice

181 Protein-deficient mice were infected with Cryptosporidium parvum

182 WT and B2-deficient mice were infected with H1N1 PR8 by intranasal

183 ve in polarization and chemotaxis, and TIPE2-deficient mice were resistant to leukocyte-mediated neur

184 reatment of wild-type mice with CSP, and uPA-deficient mice were unresponsive.

185 ry cytokine production are impaired in M-ILK-deficient mice, and activation of epithelial NF-kappaB a

186 reduced IFN-I responses in WT but not CD11b-deficient mice, and protected lupus-prone MRL/Lpr mice f

187 PFC underlies cognitive dysfunction in Ophn1-deficient mice, as assessed using a delayed spatial alte

188 tion was diminished in myeloid-specific Egfr-deficient mice, as marked by decreased Arg1 and Il10 mRN

189 cific Ab responses were dysregulated in CCR7-deficient mice, displaying an unexpected increase in the

190 neural plasticity, we subjected C3a receptor-deficient mice, GFAP-C3a transgenic mice expressing biol

191 In c-REL/IkappaBNS double-deficient mice, Treg numbers were dramatically reduced,

192 ing in vivo and in vitro analysis using TC10-deficient mice, we define the poorly studied Rho GTPase

193 r T-cell development, as demonstrated by LAT-deficient mice, which show a complete lack of peripheral

194 cts of antibiotics were phenocopied in Stat1-deficient mice, with no additional suppression by antibi

195 iary proteins are severely disturbed in Npc1-deficient mice.

196 but this effect was delayed in interleukin 6-deficient mice.

197 levels were correspondingly reduced in SR-AI-deficient mice.

198 wall after DVT induction were reduced in MC-deficient mice.

199 earance, which was corroborated using CXCL10-deficient mice.

200 ced in the liver and skeletal muscles of Cry-deficient mice.

201 were lower before and after ischemia in CD73-deficient mice.

202 ncer cells adopted in response to a nutrient-deficient microenvironment.

203 d AD risk may be at least partly mediated by deficient microglia polarization toward amyloid deposits

204 HS-deficient MM cells exhibited strongly decreased autocrin

205 els of human breast cancer or in a cyclin D1-deficient model, we observed a cyclin D1-mediated reduct

206 After M. tuberculosis infection, TOLLIP-deficient monocytes demonstrated increased IL-6, increas

207 tes proximal TCR signaling, we studied TRAF3-deficient mouse and human T cells, which showed a marked

208 human cells and cystathionine beta-synthase-deficient mouse brains, we find an acute and chronic inh

209 TRPC6-deficient mouse hearts 1 week after transverse aortic co

210 ogical function of FDXR, we generated a Fdxr-deficient mouse model and found that loss of Fdxr led to

211 th behavioral characterization of the Chrna7 deficient mouse model appeared prudent.

212 c deficiency of CXCR4 in an apolipoprotein E-deficient mouse model.

213 Here we show, using Cu-deficient mouse models, that steady-state levels of ATP7

214 The new Traj18-deficient mouse strain will assist in studies of iNKT ce

215 ve characterization of different aged immune-deficient mouse strains revealed that T cells significan

216 s to R294, which is mutated in the BXH2 IRF8-deficient mouse.

217 Metabolomic profiling revealed that MS-deficient Mtb cultured on fatty acids accumulated high l

218 ke receptors (TLRs) and integrins, in a gp96-deficient murine cell line.

219 The HLCC-to-LCC ratio was rescued in FKBP65-deficient murine embryonic fibroblasts by reconstitution

220 ity to IgG-mediated arthritis in 2 mast cell-deficient murine lines: KitWsh/Wsh, which develops robus

221 ection with Listeria monocytogenes, DNA-PKcs-deficient murine macrophages produce reduced levels of I

222 By longitudinal analysis of AnxA2-deficient muscle we find that poor myofiber repair due t

223 Our data showed that the GluA1 ubiquitin-deficient mutant enhances GluA1 phosphorylation on Ser-8

224 uberculosis H37Rv DeltapapA1 sulfoglycolipid-deficient mutant had significantly diminished Congo Red

225 portantly, expression of the GluA1 ubiquitin-deficient mutants inhibited the adverse effects of Abeta

226 human embryonic 293 cell lines, while the PF-deficient mutants lacked the ability to stimulate, and t

227 osure and the stomatal VPD regulation of ABA-deficient mutants may be conditional on the initial pret

228 largely compromised, and that permitted ICP0-deficient mutants to replicate.

229 cumulated over five generations in eight MMR-deficient mutation accumulation (MA) lines of the model

230 Myomerger deficient myocytes differentiate and harbour organized s

231 s and levels of protein expression in Mettl3-deficient naive T cells.

232 We show that Mecp2-deficient neurons also lack homeostatic synaptic plastic

233 Paxillin-deficient neurons have shorter leading processes that ex

234 Multiphoton imaging revealed that paxillin-deficient neurons migrate approximately 30% slower than

235 scues the premature differentiation of Mcph1-deficient neuroprogenitors in vivo MCPH1 itself is degra

236 Wiskott-Aldrich syndrome protein-deficient neutrophils are unable to polymerize actin and

237 Activated TTP-deficient neutrophils exhibited decreased apoptosis and

238 In addition, the AP1 factor-deficient newborn mice display a collodion membrane phen

239 Compared with wild-type controls, HAT-L4-deficient newborn mice had greater body fluid loss and h

240 esults showed protection from death in NLRP3-deficient (Nlrp3(-/-)) and NLRP3 inhibitor-treated wild-

241 l protein, PS1, that binds a highly electron-deficient non-natural porphyrin at temperatures up to 10

242 2 kinase, however, neither a phosphorylation-deficient nor a phosphomimetic mutant of SNAP23 can medi

243 nt dual-metal catalyzed reaction of electron-deficient o-chlorovinylpyridines with o-aminophenylboron

244 Natural killer T cells- deficient or mice injected with anti CD1d antibodies exh

245 larization, and transgenic mouse models with deficient or spontaneous retinal/choroidal neovasculariz

246 ovary control cells (CHOK1) and alphavbeta3-deficient or transfected HEK293 cells.

247 Four weeks after AngII-Ald infusion, PAI-1-deficient (PAI-1(-/-)) mice developed severe cardiac fib

248 Jarid2-deficient pancreases exhibit impaired deposition of RNAP

249 TCR expression, in a newly identified CD247-deficient patient are described.

250 Samples from 18 PNPO deficient patients (1 day-25 years), 13 children with ot

251 Mutations in ARTEMIS-deficient patients impaired the interaction with the C t

252 -specific IgE revealed plasma IgE from DOCK8-deficient patients is directed against staple food antig

253 Studies of CD40L-deficient patients reveal the critical role of CD40L-CD4

254 ful in gauging the clinical response of LRBA-deficient patients to CTLA4-Ig therapy.

255 ining the infectious susceptibility of DOCK8-deficient patients.

256 Naive PD-L2-deficient (PD-L2(-/-)) mice produced significantly more

257 all of which are aberrantly elevated in DND1-deficient PGCs.

258 e measurements from the leaves of polyprenol-deficient plants revealed impaired photosystem II operat

259 xudation was strongly reduced only in ABCG37 deficient plants.

260 model inflammatory stimuli, and alphaMbeta2-deficient PMN displayed defective inflammatory functions

261 ur at every level of the spinal cord of PPT1-deficient (Ppt1(-/-) ) mice before the onset of neuropat

262 aily iodine supplementation in mildly iodine-deficient pregnant women had no effect on child neurodev

263 he viral long terminal repeat (LTR) from Vpr-deficient proviruses was significantly reduced.

264 We found that deficient pS38 abated AID chromatin association and CSR

265 By contrast, in REDD1-deficient R28 cells, neither hyperglycemic conditions no

266 experiment, injecting mouse PSCs into Pdx-1-deficient rat blastocysts, we generated rat-sized pancre

267 aracterized the metabolic phenotypes of PHD2-deficient RAW cells and primary PHD2 knockout bone marro

268 As a consequence, HVEM-deficient recipients failed to afford protection against

269 Both SUFC- and SUFD-deficient RNAi lines accumulated the same intermediate,

270 Mice infected with covR-deficient S. agalactiae produced less proinflammatory cy

271 omyelin) are significantly elevated in NECL4-deficient Schwann cells, particularly specific subspecie

272 erapeutic efficacy from gene therapy for ADA-deficient SCID, with an excellent clinical safety profil

273 We found that covR-deficient serotype III S. agalactiae 874391 was signific

274 -zone) were detected in both the SUMOylation-deficient-Sf1(2KR/2KR) and Dax1 knockout mouse lines, wi

275 Adoptive transfer of CerS6-deficient splenocytes, which have significantly decrease

276 combined immunodeficient common gamma chain-deficient stem cell factor (huNSG) mice exhibited robust

277 Infection with a PT-deficient strain induced severe pulmonary inflammation b

278 Ear thickness of wild-type (wt) and Sucnr1-deficient (Sucnr1(-/-) ) mice, sensitized and challenged

279 ty against tumor cells, and mice with NFATc1-deficient T cells are defective in controlling Listeria

280 found that, unlike wild-type T cells, SMAD4-deficient T cells differentiate into TH17 cells in the a

281 Notably, A2AR-deficient, terminally mature NK cells retained prolifera

282 Moreover, residual CD28-deficient TFR cells showed a diminished suppressive capa

283 c cystic areas were decreased by 45% in TGR5-deficient TGR5(-/-) ;Pkhd1(del2/del2) mice.

284 Furthermore, using IFN-gamma-deficient Th17 cells, we demonstrate the disease-amplify

285 Spi2A-deficient TH2 cells were studied in in vitro culture or

286 A20-deficient thymic Treg cells exhibit reduced dependence o

287 Additionally, T-bet-deficient Treg cells lacked expression of the Th1-charac

288 tion or elevated mTORC1 signalling in Ndfip1-deficient Treg cells.

289 In marked contrast, Atm-deficient tumors displayed an enhanced response to the t

290 Forty-eight patients (10.7%) had MMR-deficient tumors, and 40 patients (83.3%) had at least 1

291 ary schwannoma cells, the most common Merlin-deficient tumour and the hallmark for NF2.

292 to potentiate PARP inhibitor treatment of HR-deficient tumours.

293 In contrast, versican-deficient (Vcan(-/-)) lungs did not exhibit increases in

294 ycline-inducible mutant demonstrated that I2-deficient virions are defective in cell entry.

295 deletion also impaired transmission of ORF7-deficient virus among the neuronal cells.

296 A Us3-deficient virus was hypersensitive to low-energy-induced

297 portant target in the mechanism of complex 1-deficient vision loss.

298 adiance (<0.9 Hz) and stationary images were deficient when stimuli were rendered invisible for melan

299 ncreases in growth and total P content of Pi-deficient wild-type rice (Oryza sativa) seedlings.

300 The dmrt1 deficient ZZ fish grew much faster than ZZ male control.