ライフサイエンスコーパス: deficient mice

1 s observed in diabetic and nondiabetic REDD1-deficient mice.

2 in Morris water maze-trained IL-4- and IL-13-deficient mice.

3 e increased disease susceptibility of Il22bp-deficient mice.

4 ced in the liver and skeletal muscles of Cry-deficient mice.

5 , and reduced in neurons isolated from Trpa1-deficient mice.

6 were lower before and after ischemia in CD73-deficient mice.

7 inflection of its posterior edge in the Pax7-deficient mice.

8 ption, a precursor of HF development in SPEG-deficient mice.

9 rol of the Mb1 gene in Spib (encoding Spi-B)-deficient mice.

10 he plasma lipid profiles in apolipoprotein E-deficient mice.

11 remains inappropriately expressed in Raptor-deficient mice.

12 eeding Neu5Gc-rich chow to human-like Neu5Gc-deficient mice.

13 oluble P-selectin in wild-type but not in MC-deficient mice.

14 -/-) , SPPL2a(-/-) , and SPPL2a-MHCII double-deficient mice.

15 rmation of platelets in GPS cases and Nbeal2-deficient mice.

16 MDAR-dependent LTP were lacking in adult n-3-deficient mice.

17 ting altered lipid metabolism in these Panx1-deficient mice.

18 expression and thymocyte maturation in Gfi1-deficient mice.

19 bolished in muscle-specific AMPKalpha1alpha2-deficient mice.

20 ively with age, which was exacerbated in Hfe-deficient mice.

21 challenge and delayed viral clearance in C3-deficient mice.

22 ioral abnormalities described in the Zdhhc13-deficient mice.

23 signature similar to that observed in Ptch1-deficient mice.

24 -1 and NKG2A that occurs even in MHC class I deficient mice.

25 T, but Tm colonization in both WT and Raptor deficient mice.

26 d behavioural impairments observed in BLOC-1-deficient mice.

27 ction for 8 h and was without effect in CFTR-deficient mice.

28 To extend these findings, we generated Zbtb4-deficient mice.

29 mpletely resolved granulomas in myeloid TSC2-deficient mice.

30 amitriptyline or from acid sphingomyelinase-deficient mice.

31 vage was impaired in germ-free mice and TLR4-deficient mice.

32 deficient mice and markedly reduced in C5aR1-deficient mice.

33 tic wild-type mice were also absent in REDD1-deficient mice.

34 gated PTL and uterine inflammation in B cell-deficient mice.

35 xide levels, compared to wild type and TRPC3-deficient mice.

36 e enhanced antifungal response found in JNK1-deficient mice.

37 lpha-deficient, mast cell-deficient, or eNOS-deficient mice.

38 learance of Pneumocystis infection in IL-17A-deficient mice.

39 sely reflected the one observed in the ACKR1-deficient mice.

40 ores spermatogenesis and fertility in Rpl10l-deficient mice.

41 nt of atherosclerosis in LDL-receptor/ApoB48-deficient mice.

42 esvirus infection and disease in CXCL10(-/-) deficient mice.

43 duced leukocyte rolling and adhesion in P2X7-deficient mice.

44 No such effect was seen in PPAR-alpha-deficient mice.

45 ispensable for the induction of AAD in IL-15-deficient mice.

46 1P) transporter spinster homologue 2 (Spns2)-deficient mice.

47 aired lymphatic function in ubiquitous Panx1-deficient mice.

48 rrogated by using mast cell- and FcgammaRIIb-deficient mice.

49 or plasminogen activator inhibitor-1 (PAI-1)-deficient mice.

50 iary proteins are severely disturbed in Npc1-deficient mice.

51 es to altered barrier permeability in Stard7-deficient mice.

52 g, also rescued palate morphogenesis in Pax9-deficient mice.

53 peptidase (PREP) and was validated using Fap-deficient mice.

54 wall after DVT induction were reduced in MC-deficient mice.

55 but this effect was delayed in interleukin 6-deficient mice.

56 levels were correspondingly reduced in SR-AI-deficient mice.

57 enicity was restored in either RIPK3- or DAI-deficient mice.

58 tably maintained after WNV infection in MAVS-deficient mice.

59 hanges in inducible conditional neuroplastin-deficient mice.

60 earance, which was corroborated using CXCL10-deficient mice.

61 hils in the lungs of leukotriene C4 synthase-deficient mice.

62 N-lambda by extending these findings in Rag1-deficient mice.

63 tis and that colitis was attenuated in IL-19-deficient mice.

64 is accelerated, not only in tristetraprolin-deficient mice after cytotoxic T lymphocyte depletion, b

65 ed in a similar manner for control and Igf1r-deficient mice after HDM exposure.

66 pro-inflammatory cytokines generated in MAVS-deficient mice after WNV infection.

67 ects type I or type I/II interferon receptor-deficient mice against lethal ZIKV challenge.

68 ed a diminished c-wave amplitude in the CLN5 deficient mice already at 1 month of age, indicative of

69 f hyperoxaluria, Tnfr1-, Tnfr2-, and Tnfr1/2-deficient mice also lacked the intrarenal CaOx depositio

70 challenge with S. pneumoniae The cPLA2alpha-deficient mice also suffered no bacteremia and survived

71 ypertrophy using 1-, 5- and 12-month old Hfe-deficient mice, an animal model of hemochromatosis in hu

72 he angiogenic effects were confirmed in IL-5-deficient mice and addition of IL-5 antibody.

73 Furthermore, use of gene-deficient mice and adoptive cell transfer experiments re

74 Skin of CTSH-deficient mice and CTSH short hairpin RNA knockdown kera

75 eep and temperature rhythms of Lhx1- and Vip-deficient mice and found loss of acute light control of

76 study, we generated and characterized PNPLA1-deficient mice and found that PNPLA1 is crucial for epid

77 To address this question, we generated Cic-deficient mice and human oligodendroglioma cell models.

78 nalling within the prefrontal cortex of Phf8 deficient mice and identify the serotonin receptors Htr1

79 meliorated in PPK (Klkb1)-deficient and FXII-deficient mice and in wild-type (WT) mice pretreated wit

80 Stable patrolling is unaffected in CX3CR1-deficient mice and involves the contribution of LFA-1 (l

81 development was abrogated in FcRgamma chain-deficient mice and markedly reduced in C5aR1-deficient m

82 ass, and increased lifespan, similar to S6K1-deficient mice and mice with adipocyte-specific deficien

83 To test this hypothesis, we used Il22bp-deficient mice and murine models of acute liver damage i

84 ed disease onset, prolonged life span of Tk2-deficient mice and restored mtDNA copy number as well as

85 chondrial function in hepatocytes of Zdhhc13-deficient mice and Zdhhc13-knockdown Hep1-6 cells.

86 ry cytokine production are impaired in M-ILK-deficient mice, and activation of epithelial NF-kappaB a

87 IGF-1 rhythms are disrupted in Cry-deficient mice, and IGF-1 level is reduced by 80% in the

88 y attenuated in IL-1R-deficient and IL-1beta-deficient mice, and IL-1beta is found in the blood, cere

89 are equivalently attenuated in IL-33- and LT-deficient mice, and optimal ILC2 activation reflects pot

90 reduced IFN-I responses in WT but not CD11b-deficient mice, and protected lupus-prone MRL/Lpr mice f

91 tibody did not affect RENCA tumors in T cell-deficient mice, and treatment with an anti-class II MHC

92 absence of DNGR-1 in Apoe (apolipoprotein e)-deficient mice (Apoe(-/-)) and bone marrow-restricted de

93 Furthermore, Cu-deficient mice are highly colonized by UPEC, indicating

94 Gal-3-deficient mice are more susceptible to cryptococcosis th

95 d B-cell migration, whereas B cells from IgM-deficient mice are normal in this respect.

96 Here, we find that Hic-5-deficient mice are postnatal viable with normal cortical

97 miR-34a-deficient mice are resistant to collagen-induced arthrit

98 PGRN-deficient mice are sensitive to Listeria monocytogenes b

99 s water maze task, we demonstrate that IL-13-deficient mice are significantly impaired in working mem

100 other than Vip, yet activity rhythms in Lhx1-deficient mice are similar to Vip(-/-) mice under light-

101 PFC underlies cognitive dysfunction in Ophn1-deficient mice, as assessed using a delayed spatial alte

102 tion was diminished in myeloid-specific Egfr-deficient mice, as marked by decreased Arg1 and Il10 mRN

103 ption in DMT1-deficient rats and ferroportin-deficient mice, as well as hemoglobinization in DMT1- an

104 or (DTR) transgenic and IFN-alpha receptor 1-deficient mice, as well as purified primary ILC2s, to re

105 we have generated a new strain of iNKT cell-deficient mice by deleting the Traj18 locus using CRISPR

106 esent in WT mice and hyperactivated in 53BP1-deficient mice, by which microbiota signal via Toll-like

107 metastases was both strongly inhibited in C3-deficient mice (C3(-/-) mice), with tumors undetectable

108 Interestingly, NSC loss in alpha-SYN-deficient mice can be prevented by viral delivery of hum

109 de that cryptosporidial infection in protein-deficient mice can mimic some metabolic changes seen in

110 y and increased lethality were seen in Hdac8-deficient mice challenged with serial 5-fluorouracil tre

111 in IL-17 production during infection, IL-17A-deficient mice cleared Pneumocystis infection with kinet

112 gnificantly increased in epidermis of TC-PTP-deficient mice compared to control mice following TPA tr

113 d fractional shortening) deteriorated in TNC-deficient mice compared with their wild-type counterpart

114 ng was diminished in leukotriene C4 synthase-deficient mice compared with wild-type mice, with increa

115 NF-alpha and PCNA responses subsided in Nox4-deficient mice compared with wildtype mice.

116 ytokines from activated cardiac MSCs of TLR4-deficient mice, compared with WT cardiac MSCs.

117 toantibodies fail to induce BP in eosinophil-deficient mice, confirming that eosinophils are required

118 observed increases in viral titers in NLRC5-deficient mice correlated with impaired effector CD8(+)

119 meability barrier formation in global CGI-58-deficient mice could be reversed via transgenic restorat

120 imary mouse B cells from wild-type and STAT6-deficient mice cultured for 4 d in the presence or absen

121 the L. donovani-infected livers of chemokine-deficient mice (CXCR6(-/-) mice were used as CXCL16-defi

122 In conclusion, CLN5 deficient mice develop early vision loss that reflects t

123 Hair cells of pejvakin-deficient mice develop normal rootlets, but hair bundle

124 Similarly, 92% of COX-2-deficient mice developed anastomotic leakage (P = 0.003)

125 Here, we have reported that miR-146a-deficient mice developed more severe experimental autoim

126 gammadelta-T-cell-deficient mice developed profound RPE and retinal damage

127 NLRP10-deficient mice developed vigorous adaptive immune respon

128 the highly reduced Treg compartment, double-deficient mice did not develop autoimmunity even when ag

129 Notably, a quarter of the Smarcal1-deficient mice did not develop tumors.

130 In contrast, RBPJkappa-deficient mice did not experience AAI and airway hyperre

131 MET-deficient mice did not have defects in intestinal homeos

132 alphaII spectrin-deficient mice die before 1 month of age and have disrup

133 fail to form syncytial myotubes, and Minion-deficient mice die perinatally and demonstrate a marked

134 Here we demonstrate that CXCR2-deficient mice display a counterintuitive transient exag

135 rates however that both ActRIIB- and ActRIIA-deficient mice display a hypertrophic phenotype.

136 Nhlh2-deficient mice display growth deficiencies as adolescent

137 The Igf1r-deficient mice displayed a distinctly thinner epithelial

138 Importantly, Ip3r2-deficient mice displayed a reduction of PID frequency an

139 eported here, we found that uninfected Irgm1-deficient mice displayed high levels of serum cytokines

140 Retinas from NIX-deficient mice displayed increased mitochondrial mass, r

141 intravaginal infection with Chlamydia, CCR7-deficient mice displayed markedly reduced Ag-specific CD

142 cific Ab responses were dysregulated in CCR7-deficient mice, displaying an unexpected increase in the

143 ta-enhanced IFNgamma production, as IFNgamma-deficient mice do not exhibit protective effects.

144 Moreover, miR-146a-deficient mice do not resolve inflammation after discont

145 ous studies reporting arthrogryposis in Lgi4-deficient mice due to peripheral hypomyelination.

146 e-producing ILC2 and ILC3 responses in STAT1-deficient mice during RSV infection.

147 lthough signs of colitis are absent in IL10R-deficient mice during the first two weeks of life, intes

148 We studied ENPP1-deficient mice (Enpp1 (-/-) ) to determine how the enzym

149 nt (Erg (cEC-Het) ) and inducible homozygous deficient mice (Erg (iEC-KO) ), in a SMAD3-dependent man

150 uated, but not completely suppressed in gene-deficient mice, especially in MyD88(-/-) mice.

151 Apcdd1-deficient mice exhibit a transient increase in vessel de

152 Here, we report that Igfbp7-deficient mice exhibit constitutively active IGF signali

153 Cardiomyocytes from Gas2l3-deficient mice exhibit increased expression of a p53-tra

154 Furthermore, lipin-2-deficient mice exhibit increased sensitivity to high lip

155 AMCase-deficient mice exhibit premature morbidity and mortality

156 uce metastasis, we found that thrombopoietin-deficient mice exhibited a 90% relative decrease in mega

157 The Igf1r-deficient mice exhibited an increased expression of the

158 we reported that myeloid cell-specific Nrp1-deficient mice exhibited enhanced susceptibility to ceca

159 During pneumococcal pneumonia, Miwi2-deficient mice exhibited increased expression of inflamm

160 Mast cell-deficient mice exhibited increased FXIIIA plasma and act

161 On the other hand, the Igf1r-deficient mice exhibited no AHR, and a selective decreas

162 As expected, CCR7-deficient mice exhibited reduced lymphocyte trafficking

163 CX3CR1-deficient mice exhibited significantly lower expression

164 Treg-deficient mice exhibited substantially impaired remyelin

165 Upon cyclosporin A treatment, Nupr1-deficient mice exhibited worse renal tubular lesions tha

166 Relative to wild-type, claudin-2-deficient mice experienced severe disease, including inc

167 Monocytes from C3aR-deficient mice express a reduced level of adhesion molec

168 In this study, we show that CX3CR1-deficient mice fail to resolve gut inflammation despite

169 CD300f-deficient mice failed to resolve dextran sulfate sodium-

170 atherosclerosis induced in apolipoprotein E-deficient mice fed a high-lipid diet.

171 regulate myelin thickness, we examined FGFR2-deficient mice for the expression of key signaling molec

172 In response to antigen, SAP-deficient mice form extrafollicular B cell responses but

173 neural plasticity, we subjected C3a receptor-deficient mice, GFAP-C3a transgenic mice expressing biol

174 slices obtained from forebrain specific HCN1 deficient mice, global HCN1 knockouts and their wildtype

175 wild-type CAV1 into SECs isolated from Cav1-deficient mice, GRK2 association with CAV1 was evident,

176 We showed that JNK1-deficient mice had a significantly higher survival rate

177 Consistent with these effects, Grhl2-deficient mice had diabetes insipidus, produced dilute u

178 ssing wild-type Gsalpha alleles, the Gsalpha-deficient mice had enlarged glomeruli with mesangial exp

179 cific Jagged 1 or Jagged 2 single- or double-deficient mice had eosinophilic airway inflammation and

180 Folate deficient mice had lower serum folate (-60%).

181 In contrast to C3(-/-) mice, C5-deficient mice had no apparent defect in platelet activa

182 contrast sensitivity, whereas diabetic REDD1-deficient mice had no visual dysfunction.

183 In response to Ang-II, TLR4 deficient mice had reduced renal resistive index and inc

184 s of virus-specific T cells in the CNS, Ccr7-deficient mice had significantly higher CNS viral loads

185 LC-extrinsic mechanisms, we found that STAT1-deficient mice had significantly increased expression of

186 Cyp27a1-deficient mice had significantly reduced 27HC levels, HS

187 We report that CCRL2-deficient mice have a defect in neutrophil recruitment a

188 Studies that used splenocytes from GPR120-deficient mice have confirmed this conclusion.

189 CCR7-deficient mice have profoundly altered lymphocyte recirc

190 In agreement, Cry-deficient mice have reduced body ( approximately 30% red

191 rm-free (GF) and Toll-like receptor-2 (Tlr2)-deficient mice have reduced thrombus growth after caroti

192 Using loss-of-function pericyte-deficient mice, here we show that pericyte degeneration

193 poietic progenitor cells engrafted in immune deficient mice (huNSG) results in viral latency that can

194 infection), whereas studies with eosinophil-deficient mice identified this innate immune cell as ess

195 myeloid progenitors from NFI-A myeloid cell-deficient mice impeded myeloid cell maturation and promo

196 IgG transfer in IgG-deficient mice implicated IgG as the pathogenetic ligand

197 utor to excessive inflammation seen in Irgm1-deficient mice in different contexts.

198 onses are similar to those of TLR4 and MyD88 deficient mice in these models and confirm that GSTO1-1

199 , prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clea

200 l-like receptor 2 (TLR2)-, TLR4-, and TLR2/4-deficient mice indicated that Acanthamoeba-induced proin

201 capitulates the phenotype of germline Smurf2-deficient mice, indicating that SMURF2 regulates osteobl

202 Vitamin A-deficient mice infected with S. mansoni had disrupted li

203 contrast, reduced epithelial damage in M-ILK-deficient mice is correlated with elevated levels of epi

204 he bone mass phenotype in Smurf2- and Smurf1-deficient mice is opposite, indicating that SMURF2 has a

205 ITSN-deficient mice (knockout/heterozygous and knockdown) wer

206 In piRNA-deficient mice, L1-overexpressing male germ cells exhibi

207 As a consequence, PNPLA1-deficient mice lacked a functional corneocyte-bound lipi

208 Melanomas in PP;Trp53-deficient mice lacked either Ras or Braf mutations, and

209 1 in Ldlr (low-density lipoprotein receptor)-deficient mice (Ldlr(-/-)) significantly reduce inflamma

210 y was designed to investigate whether Chrna7 deficient mice manifest phenotypes related to those seen

211 s in synaptic function and plasticity in DBN deficient mice may indicate robust compensatory mechanis

212 er expression levels of IL-33 in cadherin-11-deficient mice mediated ILC2 activation, resulting in hi

213 We previously showed that Mer-deficient mice (Mer(-/-)) have increased germinal center

214 th wild-type controls, miR106b-93-25 cluster-deficient mice (miR106b-93-25(-/-)) showed decreased ang

215 Similar results were observed in MSLN-deficient mice (Msln-/- mice) or mice deficient in the M

216 Phf8 deficient mice neither display obvious developmental def

217 Compared to NKG2D-deficient mice, NKG2D-sufficient mice display accelerate

218 We analyzed alphaII spectrin-deficient mice of both sexes and found that loss of alph

219 We analyzed alphaII spectrin-deficient mice of both sexes and found that, in myelinat

220 ammation in low-density lipoprotein receptor-deficient mice on a Western-type diet.

221 7 supplementation on ovariectomized estrogen-deficient mice on various immune and skeletal parameters

222 emic complement activation occurred in GCase-deficient mice or after pharmacological inhibition of GC

223 rtial hepatectomy to natural killer T cells- deficient mice or to anti CD1d1-treated mice.

224 tabolic fitness in adipocyte liver kinase b1-deficient mice, our results reveal an unexpected role of

225 IgG1-deficient mice produce more porin-specific IgG2a, result

226 As a result, NKG2D-deficient mice produce significantly less Ag-specific Ig

227 nts, gp91phox and p22phox Consequently, Eros-deficient mice quickly succumb to infection.

228 Wild-type (WT) and B cell-deficient mice received ovalbumin (OVA) intranasally bef

229 t insulinotropic polypeptide receptor (Gipr)-deficient mice receiving background dipeptidyl peptidase

230 of MC1-R in atherosclerotic apolipoprotein E-deficient mice reduced plasma cholesterol levels and aor

231 olesterolemia (streptozotocin diabetic, apoE-deficient mice), renal STAT activation status correlated

232 254 proteins were down-regulated in Zdhhc13-deficient mice, representing potential ZDHHC13 substrate

233 s administration of recombinant CCL5 to C3aR-deficient mice rescues the defects in inflammatory cell

234 TLR9-deficient mice responded significantly weaker to Id-3F7.

235 TUB1-deficient cells and in tissues of STUB1-deficient mice resulting in reduced TFEB activity.

236 e during PIDs is strongly curtailed in Ip3r2-deficient mice, resulting in ameliorated calcium overloa

237 tive transfer of splenic B cells into B cell-deficient mice revealed that the suppressive effects on

238 e serial transplantation assays using Zfp521-deficient mice revealed that ZFP521 regulates HSC self-r

239 Upon transplantation into immune-deficient mice, SF3B1 mutated MDS-RS HSCs differentiated

240 in the marginal sinus of the spleen of FVIII-deficient mice shortly after injection, with significant

241 In contrast, GSTO1-1 deficient mice show a more severe inflammatory response

242 Furthermore, B cells from IgD-deficient mice show defects in CXCL12-mediated CXCR4 sig

243 ethality in infected animals, whereas B cell-deficient mice showed CD4(+) T cell loss but recovered f

244 HSPCs) and developing thymocytes in Smarcal1-deficient mice showed increased DNA damage and apoptosis

245 Importantly, Pfn2-deficient mice showed iron accumulation in discrete area

246 Compared to wild-type mice, IRAK-M-deficient mice showed reduced tubular injury, leukocyte

247 thogen-free conditions into germ-free Nlrp12-deficient mice showed that NLRP12 and the microbiome eac

248 Notably, deletion of Pink1 in Atad3a-deficient mice significantly 'rescued' the mitophagy def

249 igeminal ganglia of latently infected CXCL10-deficient mice significantly restored the number of loca

250 We found that Muc2-deficient mice succumb to lethal disease from ETBF colon

251 se (m)4-1BB is reduced in galectin-9 (Gal-9)-deficient mice, suggesting a pivotal role of Gal-9 in m4

252 eased specifically in the hindbrain of IFNAR-deficient mice, suggesting that IFNAR signaling critical

253 f conjunctival mast cells were lower in CCL7-deficient mice than in wild-type mice.

254 t(W-sh/W-sh) mice and two types of mast cell-deficient mice that have normal c-kit ("Hello Kitty" and

255 inflammation was marginally reduced in ILC2-deficient mice that received combined DEP+HDM, it was ab

256 In iron deficient mice, the histone deacetylase 3 inhibitor RGFP

257 Exposure of Interleukin 10 (il10)-deficient mice to cigarette smoke accelerated developmen

258 We used Il22 x Il22bp double-deficient mice to show that this effect is indeed due to

259 T cells transferred from DGKzeta-deficient mice to wild-type tumor-bearing recipients con

260 le actin-positive cells in the lungs of ITSN-deficient mice, transduced with the EHITSN relative to w

261 In c-REL/IkappaBNS double-deficient mice, Treg numbers were dramatically reduced,

262 Here, we report that constitutive Twf2a-deficient mice (Twf2a(-/-)) display mild macrothrombocyt

263 ht chain kinase expression decreased in Cd14-deficient mice under steady-state conditions and in the

264 +)Ly6C(+) monocytes into the liver in Il22bp-deficient mice upon liver damage.

265 t perseveration phenotype displayed by Ophn1-deficient mice using a Y-maze spatial working memory (SW

266 aluminum hydroxide can be achieved in Foxp3-deficient mice using nondepleting anti-CD4 Abs.

267 characterized the kynurenine 3-monooxygenase-deficient mice using six behavioral assays relevant for

268 on and preterm births were observed in MCPT4-deficient mice versus MCPT4-sufficient mice.

269 hy subjects caused insulin resistance in IgG-deficient mice via FcgammaRIIB, indicating that similar

270 ination and preterm births observed in MCPT4-deficient mice was abolished when GBS was deficient in e

271 ncrease in Treg cells in T cell-specific A20-deficient mice was already observed in CD4(+) single-pos

272 Cardiac hypertrophy in 12-month old Hfe-deficient mice was consistent with decreased alpha myosi

273 ing in vivo and in vitro analysis using TC10-deficient mice, we define the poorly studied Rho GTPase

274 -specific IFN-gamma receptor 2 (IFN-gammaR2)-deficient mice, we show that IFN-gamma causes ECM by sig

275 nd antisteatotic effects observed in ZFP36L1-deficient mice were accompanied by impaired lipid absorp

276 ze and insulin content in pancreata of A2AAR-deficient mice were decreased compared with control mice

277 Protein-deficient mice were infected with Cryptosporidium parvum

278 WT and B2-deficient mice were infected with H1N1 PR8 by intranasal

279 All other blood cell counts in Tpm4-deficient mice were normal.

280 Runx1-deficient mice were protected against adverse cardiac re

281 ced adipose tissue inflammation, cadherin-11-deficient mice were protected from obesity-induced gluco

282 ve in polarization and chemotaxis, and TIPE2-deficient mice were resistant to leukocyte-mediated neur

283 reatment of wild-type mice with CSP, and uPA-deficient mice were unresponsive.

284 njected and control diet-fed leptin receptor-deficient mice were used as respective controls.

285 Cytokine reporter mice and gene-deficient mice were used to dissect the immunologic mech

286 In the present study we use Rab27a-deficient mice which show diminished trafficking of myco

287 infusion, or in peptidylarginine deiminase-4-deficient mice (which have impaired NET production), res

288 Infection of Rag-1-deficient mice (which lack adaptive immune cells) or spe

289 nisms behind this pathology, we studied Ccr7-deficient mice, which afforded us the capacity to study

290 used wild-type (WT) with IL-17RA and IL-17RC-deficient mice, which dramatically enhanced the suscepti

291 r T-cell development, as demonstrated by LAT-deficient mice, which show a complete lack of peripheral

292 c glucose tolerance was improved in obese GR-deficient mice, which was associated with increased insu

293 adoptively transferred into NOD SCID gammaC-deficient mice, which were given isotype or anti-inducib

294 We bred miR-146a-deficient mice with 2D2 T cell receptor-Tg mice to gener

295 ients carrying TREM2 risk variants and TREM2-deficient mice with AD-like pathology have abundant auto

296 plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-beta pathology.

297 male low-density lipoprotein receptor (Ldlr) deficient mice with an XX or XY sex chromosome complemen

298 Treatment of TRPC6-deficient mice with streptozotocin caused severe reducti

299 cts of antibiotics were phenocopied in Stat1-deficient mice, with no additional suppression by antibi

300 how altered lymphocyte distribution in CCR7-deficient mice would affect host responses to Chlamydia