ライフサイエンスコーパス: deficient mouse

1 ptozotocin-induced diabetic apolipoprotein E-deficient mouse).

2 embryonic retinoid metabolism using a Dhrs3-deficient mouse.

3 s to R294, which is mutated in the BXH2 IRF8-deficient mouse.

4 role of Rassf5 in vivo, we generated Rassf5-deficient mouse.

5 xifen-inducible cardiomyocyte-specific Runx1-deficient mouse.

6 genesis and vascular permeability in a DEP-1-deficient mouse.

7 Similar to the GM-CSF-deficient mouse, absence of alveolar macrophage PPARgamm

8 BLM-deficient mouse and human cells suppress homeologous rec

9 coprecipitated with fibrinogen from FXIII-A-deficient mouse and human plasmas.

10 tes proximal TCR signaling, we studied TRAF3-deficient mouse and human T cells, which showed a marked

11 trating lymphocytes was also reduced in LKB1-deficient mouse and human tumors.

12 Here, we describe a Fan1-deficient mouse and show that FAN1 is required for cellu

13 assessed muscle growth and repair in Anx A1-deficient mouse (AnxA1-/-).

14 ates aortic sprouting in normal but not uPAR-deficient mouse aorta.

15 xP3-, CD4-, CD8-, or CD25-depletion and gene-deficient mouse approaches, the authors demonstrated tha

16 Using the aire-deficient mouse as a preclinical model for APS1, we have

17 Ralpha conferred tumorigenicity to Ink4a/Arf-deficient mouse astrocytes and human glioma cells in the

18 ith CTNNBL1 also fails to support CSR in AID-deficient mouse B cells.

19 acologic inhibitors or its p47(phox) subunit deficient mouse BMDM also attenuated LPS-induced PGD(2),

20 n of patient-derived GNB1 variants in Cdkn2a-deficient mouse bone marrow followed by transplantation

21 o3 phosphorylation, and Tyro3-, Axl- and Mer-deficient mouse brain endothelial cells, we show that Ty

22 H]-LY450295 binding to stargazer and gamma-8-deficient mouse brain sections, demonstrates that TARPs

23 s transfected with GluN2B S1413L in GluN2A/B-deficient mouse brain slices revealed only partial rescu

24 on of the fraction of ciliated cells in Npc1-deficient mouse brains and the human fibroblasts of NPC1

25 human cells and cystathionine beta-synthase-deficient mouse brains, we find an acute and chronic inh

26 the CerS1 protein was not detected in CerS1-deficient mouse brains.

27 Consistently, many BRCA1-deficient mouse breast tumors express higher levels of H

28 In contrast to carcinomas, BRCA1-deficient mouse carcinosarcomas resembling MBC show intr

29 unocytochemical analysis revealed that PAI-1-deficient mouse cardiac endothelial cells were more susc

30 e-2 enzymatic activity was elevated in PAI-1-deficient mouse cardiac endothelial cells.

31 Here, we generated caspase-1-deficient mouse (Casp1(Null)) on the C57BL/6 J backgroun

32 Lipidomic analysis of annexin A2-deficient mouse cells indicates that this protein plays

33 However, Ero1-deficient mouse cells still support oxidative protein fo

34 y protein changes within the nucleoli of Arf-deficient mouse cells.

35 ly conserved, we have expressed gp93 in gp96-deficient mouse cells.

36 ic resonance imaging and type I IFN receptor-deficient mouse chimeras, we demonstrate HSV-1 gains acc

37 The PPT1-deficient mouse (Cln1(-/-)) is a useful phenocopy of hum

38 In ADAM17-deficient mouse colonic epithelial (ADAM17(-/-) MCE) cel

39 The microbiota of MyD88- and TLR-deficient mouse colonies differed markedly, with each co

40 Thus, differences between TLR-deficient mouse colonies reflected long-term divergence

41 Functional analysis of NCKX4-deficient mouse cones revealed that this exchanger is es

42 natures in a muscle- and heart-specific CPT2-deficient mouse (Cpt2(M-/-)) model.

43 test our hypothesis: 1) the leptin receptor deficient mouse (dbdb) model of diabetic polyneuropathy

44 e production was TLR7 dependent because TLR7-deficient mouse DCs did not respond and TLR7 inhibitory

45 The non-anemic hippocampal iron-deficient mouse demonstrated upregulation of all 7 genes

46 Reconstitution of RelA-deficient mouse embryo fibroblast cells with wild-type R

47 ircular heteroduplex DNA in extracts of Exo1-deficient mouse embryo fibroblast cells.

48 Accordingly, p19(Arf)-deficient mouse embryo fibroblasts (MEFs) arrest in resp

49 a, lymphoma, and kidney tumor and that PCBP4-deficient mouse embryo fibroblasts (MEFs) exhibit enhanc

50 e C terminus repressed Hh signaling in Ptch1-deficient mouse embryo fibroblasts and that repression w

51 -type PS1 at equal gene dosage in presenilin-deficient mouse embryo fibroblasts resulted in trans-dom

52 In RNF8-deficient mouse embryo fibroblasts, ubiquitination of bo

53 uction of senescence is accelerated in Rrm2b deficient mouse embryo fibroblasts.

54 We found that Plp2-deficient mouse embryonic fibroblast and human fibroblas

55 morphism and cell growth was found in Fkbp52-deficient mouse embryonic fibroblast cells.

56 ivity can be detected in two independent NCT-deficient mouse embryonic fibroblast lines and blocked b

57 p53 protein was increased in resting Mule-deficient mouse embryonic fibroblasts (MEFs) and embryon

58 Upon LPS stimulation, both rictor-deficient mouse embryonic fibroblasts (MEFs) and rictor

59 RelA-deficient mouse embryonic fibroblasts (MEFs) complemente

60 At the cellular level, the Cdc14b-deficient mouse embryonic fibroblasts (MEFs) grew more s

61 MARCKS-deficient mouse embryonic fibroblasts (MEFs) responded t

62 displayed no apparent abnormalities, LPA(4)-deficient mouse embryonic fibroblasts (MEFs) were hypers

63 sequently, we generated and rescued SKAP-Hom-deficient mouse embryonic fibroblasts (MEFs) with WT SKA

64 We first used immortalized PS-deficient mouse embryonic fibroblasts (MEFs), and found

65 iological experiments using engineered Mcl-1 deficient mouse embryonic fibroblasts (MEFs, reliant onl

66 uced activation of JNK1 is augmented in Miz1-deficient mouse embryonic fibroblasts (Miz1(-/-) MEFs),

67 we used normal and eIF2alpha phosphorylation-deficient mouse embryonic fibroblasts and applied a micr

68 dria induced respiratory dysfunction in Mfn2-deficient mouse embryonic fibroblasts and cardiomyocytes

69 ed PHD2 protein levels were found in PSEN1/2-deficient mouse embryonic fibroblasts and in the cortex

70 DANGER-deficient mouse embryonic fibroblasts and neurons exhibi

71 mass spectrometric approach showed that ARH3-deficient mouse embryonic fibroblasts are characterized

72 We now find that XLF-deficient mouse embryonic fibroblasts are ionizing radia

73 Conversely, SIRT1-deficient mouse embryonic fibroblasts challenged with tu

74 Inhibitor kappaB kinase 2 (IKK2)-deficient mouse embryonic fibroblasts demonstrate abnorm

75 NF2 patient tumors and Nf2-deficient mouse embryonic fibroblasts demonstrate elevat

76 In addition, MKP-1-deficient mouse embryonic fibroblasts exhibited a prolon

77 Similarly, experiments in cultured Oma1-deficient mouse embryonic fibroblasts link together impe

78 ath that can occur by apoptosis (in Bax, Bak-deficient mouse embryonic fibroblasts or HeLa cells) or

79 Using UGT1-deficient mouse embryonic fibroblasts reconstituted or n

80 Further investigation using TAK1-deficient mouse embryonic fibroblasts revealed that TNF-

81 Moreover, Hltf-deficient mouse embryonic fibroblasts show elevated chro

82 Maml1-deficient mouse embryonic fibroblasts showed impaired tu

83 Rb1-deficient mouse embryonic fibroblasts showed increased l

84 asts from laminopathy patients and lamin A/C-deficient mouse embryonic fibroblasts stably expressing

85 These functions are abrogated in lamin A/C-deficient mouse embryonic fibroblasts that recapitulate

86 -induced apoptosis in wild-type cells, c-Jun-deficient mouse embryonic fibroblasts were resistant to

87 entally relevant doses; however, in the Ku70-deficient mouse embryonic fibroblasts, exposure to a hig

88 e here that these polyps, and LKB1- and AMPK-deficient mouse embryonic fibroblasts, show dramatic up-

89 mTOR and S6 kinase phosphorylation in TSC1/2-deficient mouse embryonic fibroblasts, suggesting the pr

90 he first time, the derivation of viable LIG3-deficient mouse embryonic fibroblasts.

91 own-like differentiation is increased in Id1-deficient mouse embryonic fibroblasts.

92 NA double-strand breaks is impaired in RAP80-deficient mouse embryonic fibroblasts.

93 romosomes similar to those observed in MCPH1-deficient mouse embryonic fibroblasts.

94 estored the myogenic differentiation in TAK1-deficient mouse embryonic fibroblasts.

95 nse program was demonstrated using C/EBPbeta-deficient mouse embryonic fibroblasts.

96 thynylbenzyl-dG with wild-type and pol kappa deficient mouse embryonic fibroblasts.

97 expression, and chromatin structure of Ku70-deficient mouse embryonic fibroblasts.

98 ion-specific antibodies in wild-type and Tdg-deficient mouse embryonic stem cells (ESCs).

99 sely overlapping sites in wild-type and PRC2-deficient mouse embryonic stem cells (mESCs), demonstrat

100 ther show that polycomb repressive complex 2-deficient mouse embryonic stem cells also release Bmp4 b

101 differentiation capacity of heparan sulfate-deficient mouse embryonic stem cells and functioning in

102 We show that Wt1-deficient mouse embryonic stem cells exhibit reduced hem

103 mRtel1-deficient mouse embryonic stem cells showed sensitivity

104 Therefore we used mRtel1-deficient mouse embryonic stem cells to examine the func

105 Placentas from Grhl2-deficient mouse embryos displayed defects in BCT cell po

106 Ryk-deficient mouse embryos displayed disrupted polarity of

107 Setd5-deficient mouse embryos exhibit severe defects in neural

108 Analysis of gut morphogenesis in Shroom3 deficient mouse embryos revealed that the direction of g

109 e inactivation, knockdown of nestin in agrin-deficient mouse embryos substantially restored AChR clus

110 indings suggest that excessive 5-HT in MAO-A-deficient mouse embryos triggers cellular signaling casc

111 Finally, in Irf6-deficient mouse embryos, Grhl3 expression in the perider

112 cation of OPCs is severely affected in sulf1-deficient mouse embryos.

113 fferentiation is markedly impaired in Zfp423-deficient mouse embryos.

114 was significantly decreased in beta-catenin-deficient mouse endothelial cells, whereas its close hom

115 Using Dgcr8 and Dicer knockout (small RNA-deficient) mouse ES cells as the benchmark, we confirmed

116 High-resolution MRI of WT and Slitrk6-deficient mouse eyes revealed axial length increase in t

117 ompromised and fumarylacetoacetate hydrolase-deficient mouse (Fah-/-, Rag2-/-, Il2rg-/-, termed the F

118 ity, as DRG neurons isolated from the kinase-deficient mouse fail to respond to cGMP activation to ma

119 Conversely, E2F1-deficient mouse fibroblasts had increased Ogt and Mgea5

120 ed vacuole phenotype observed in PI(3,5)P(2)-deficient mouse fibroblasts is suppressed by overexpress

121 periments with RIG-I-, MDA5-, and RIG-I/MDA5-deficient mouse fibroblasts showed that RIG-I is the cri

122 Consistent with previous studies, Pol beta-deficient mouse fibroblasts were not hypersensitive to c

123 When expressed in Pms2-deficient mouse fibroblasts, human PMS2(R20Q) but not PM

124 Galpha13-deficient mouse germinal centre B cells and human GCB-DL

125 berrant osteoblastic differentiation in Gli3-deficient mouse (Gli3(Xt-J/Xt-J)) and resulted in cranio

126 A proton-coupled folate transporter (PCFT)-deficient mouse has been previously described as a model

127 TRPC6-deficient mouse hearts 1 week after transverse aortic co

128 and stroke volume were blunted in dysferlin-deficient mouse hearts compared with that in wild-type h

129 Young dysferlin-deficient mouse hearts expressed normal isoforms of myof

130 SIRT6-deficient mouse hearts showed hyperactivation of IGF sig

131 ent PI3K signaling is up-regulated in klotho-deficient mouse hearts vs. wild-type hearts.

132 rst-stimulated long-term potentiation in Vav-deficient mouse hippocampal slices, suggesting that Vav-

133 ng 5-hydroxymethylcytosine formation in Tet2-deficient mouse HSPCs and suppresses human leukemic colo

134 migration and proliferation using a podocan-deficient mouse in combination with a model of arterial

135 Wrb-deficient mouse inner hair cells (IHCs) displayed normal

136 Vipar- and Vps33b-deficient mouse inner medullary collecting duct (mIMDC-3

137 Unlike wild-type controls, germ-free Rab11a-deficient mouse intestines failed to tolerate the intral

138 The Necdin-deficient mouse is the only model that reproduces the re

139 d lineages based on prior data from the CD45-deficient mouse is warranted.

140 In neprilysin-deficient mouse islets, angiotensin-(1-7) and neprilysin

141 to rescue the multi-cystic phenotype of Flcn-deficient mouse kidneys.

142 erlipidemic low-density lipoprotein receptor-deficient mouse (LDLR(-/-)) model, we induced plasma APN

143 e phenotypic characterization of a PI3Kgamma-deficient mouse line and found that PI3Kgamma-deficient

144 mouse lines, including a constitutive NEGR1-deficient mouse line as well as an ENU-mutagenised line

145 re defined utilizing a new type XIV collagen-deficient mouse line.

146 We created a novel DBN deficient mouse line.

147 s neurological disease, we created a C9orf72-deficient mouse line.

148 g the regenerative phenotype of various Nogo-deficient mouse lines after experimental spinal cord inj

149 Experiments with conditionally AhR-deficient mouse lines identified keratinocytes as the pr

150 icits, we generated two neuronal progranulin-deficient mouse lines using CaMKII-Cre and Nestin-Cre.

151 s were also seen in multiple circadian clock-deficient mouse lines, our results therefore suggest tha

152 aled normal cone photoresponses in all RDH10-deficient mouse lines.

153 f Cyp1a2 and Cyp2e1 in WT, but not IRE1alpha-deficient mouse liver, indicating the essential role of

154 ssayed, i.e. in C57BL/6 wild type and VKORC1-deficient mouse liver, lung, and testis and rat liver, l

155 scription of hundreds of genes in oscillator-deficient mouse liver.

156 Furthermore, we found more apoptosis in Fak-deficient mouse livers compared to WT mouse livers after

157 intermediate-sized collagen fragments in FAP-deficient mouse lungs, consistent within vitrostudies sh

158 phorylation and downstream signaling in CD63-deficient mouse lungs.

159 lymerization in CD36-sufficient but not CD36-deficient mouse macrophages in vitro.

160 Human BRCA1 mutation carriers and BRCA1-deficient mouse mammary glands contain an abnormal popul

161 Our results suggest that the Pax7-deficient mouse may be a suitable model for investigatin

162 Our SNAP-25b-deficient mouse may represent a diabesity model.

163 The CCL2/CX3CR1 deficient mouse may thus serve as a model for age-relate

164 Finally, 10 independent HGprt-deficient mouse MN9D neuroblastoma lines showed no signs

165 Consistent with this, a cd93-deficient mouse model (in addition to apoe deficiency) d

166 By using a conditional Met-deficient mouse model (Met(flox/flox)), we show that Met

167 mmation using a tamoxifen-inducible versican-deficient mouse model (Vcan(-/-) mice).

168 ogical function of FDXR, we generated a Fdxr-deficient mouse model and found that loss of Fdxr led to

169 We have generated a prostate-specific Klf6-deficient mouse model and report here a novel role for K

170 genic mice were crossed with an LDL receptor-deficient mouse model and were fed a high-fat diet.

171 th behavioral characterization of the Chrna7 deficient mouse model appeared prudent.

172 In this study, we generated a CI-deficient mouse model by knockdown of the Ndufs6 gene us

173 tase initiates Netherton syndrome in a LEKTI-deficient mouse model by premature activation of a pro-k

174 y or 6 hours after DENV infection in a Stat1-deficient mouse model completely protected against or de

175 campal neurons and brain lysates from a Tsc1-deficient mouse model demonstrate both elevated ER and o

176 eover, studies with an HLA-transgenic, FVIII-deficient mouse model demonstrated that antibody product

177 Infusion of wild-type platelets into a TLR2-deficient mouse model established in vivo confirmation o

178 reviously, by using a radiation-induced Tp53-deficient mouse model for T-cell acute lymphoblastic lym

179 In this instance, the immune-deficient mouse model is unlikely to be appropriate for

180 We generated a TSP-1-deficient mouse model of a partial hepatectomy (PH) and

181 ip has been investigated using a fibronectin-deficient mouse model of acute liver injury.

182 panying spontaneous HA deposition in the ank-deficient mouse model of arthritis.

183 s (in vitro), with an interleukin 10 (IL-10)-deficient mouse model of colon cancer that involves long

184 the development of heart defects in a Nipbl-deficient mouse model of Cornelia de Lange Syndrome, in

185 oparticles (LNPs) to treat a Factor IX (FIX)-deficient mouse model of hemophilia B.

186 After transplantation into an immune-deficient mouse model of human liver failure, iMPC-Heps

187 e T-cell infiltration in an established Pten-deficient mouse model of human prostate cancer.

188 We generated a conditional, fibronectin-deficient mouse model of liver injury and explored wheth

189 ributed to lethal pathology in an FcgammaR2b-deficient mouse model of lupus.

190 We developed a TREM-1/3-deficient mouse model of pneumonia and found that absenc

191 We used a MECP2 deficient mouse model of RTT as a strategy to obtain ins

192 tozotocin (STZ)-induced diabetes, an insulin-deficient mouse model of type 1 diabetes.

193 The inducible neuroplastin-deficient mouse model provides a new and unique means to

194 Studies in a TRPC6-deficient mouse model revealed an essential function of

195 Furthermore, inhibition of RANKL in a Brca1-deficient mouse model substantially curtailed mammary tu

196 Using a RECQL4-deficient mouse model that recapitulates skeletal abnorm

197 h aspect of AHR biology, we generated a DREC-deficient mouse model through homologous recombination.

198 Here, we report the generation of an Usp36-deficient mouse model to examine the function of this en

199 To address this question, we used a Pten-deficient mouse model to examine thyroid cells where a m

200 We used a T cell-specific RASA1-deficient mouse model to investigate the role of the p12

201 e correlation data to develop a myotubularin-deficient mouse model with a less severe phenotype than

202 In a chromosomal instable p53 deficient mouse model with accelerated lymphomagenesis,

203 In a MHC class I-deficient mouse model, all groups including the Ad5-ID93

204 reak) shows decreased virulence in an immune-deficient mouse model, compared with a strain from 1976.

205 d on the development of a constitutively pDC-deficient mouse model, highlights the pivotal role playe

206 In the HGprt-deficient mouse model, immunohistochemical stains for TH

207 We therefore used an LDL receptor-deficient mouse model, in which type 1 diabetes can be i

208 In the folate-deficient mouse model, L-dopa resulted in a marked deple

209 Here we used a pericyte-deficient mouse model, Pdgfb(ret/ret), shown to have inc

210 Using a Tnc-deficient mouse model, we present data that suggest an a

211 Using a novel Abcg4-deficient mouse model, we show that Abcg4 was able to ex

212 By generating a TC10-deficient mouse model, we show that despite reduced tota

213 e neuronal nitric oxide synthase (nNOS(-/-)) deficient mouse model, which displays slow transit in th

214 c deficiency of CXCR4 in an apolipoprotein E-deficient mouse model.

215 umors, which correspond to tumors in the Nf1-deficient mouse model.

216 ion molecule (SLAM)-associated protein (SAP)-deficient mouse model.

217 chronic inflammation in a human-like Neu5Gc-deficient mouse model.

218 ss II and III PI3 kinases (PI3Ks) in an MTM1-deficient mouse model.

219 le muscular dystrophy type 2C, with a Col6a2-deficient mouse model.

220 also restored normal sociability in a Shank3-deficient mouse model.

221 tors and ON-bipolar cells in a retinoschisin-deficient mouse model.

222 esis in the apolipoprotein E-deficient (ApoE-deficient) mouse model of atherosclerosis.

223 ied in serum from two independent dystrophin-deficient mouse models (mdx-Delta52 and mdx-23) were con

224 Phr1-deficient mouse models (Phr1(Delta8,9) and Phr1(Magellan

225 Here we characterize autophagy-deficient mouse models and provide in vivo evidence for

226 e shown that cones degenerate in chromophore-deficient mouse models for Leber Congenital Amaurosis (L

227 However, tumors in germ-line MMR-deficient mouse models lack these histopathologic featur

228 Using established type I interferon (IFN)-deficient mouse models of ZIKV transmission in utero, we

229 Similar to other CfH-deficient mouse models on nonautoimmune backgrounds, imm

230 -GP had a longer duration of effect in FVIII-deficient mouse models, approximately a twofold prolonge

231 Studies using eosinophil-deficient mouse models, including eosinophil-derived gra

232 In BRCA1-deficient mouse models, olaparib resistance predominantl

233 Here we show, using Cu-deficient mouse models, that steady-state levels of ATP7

234 Using apolipoprotein E-deficient mouse models, we demonstrated that preventing

235 Using transporter-deficient mouse models, we show here that sorafenib-gluc

236 nactivity in long-chain fatty acid oxidation-deficient mouse models.

237 revealed by the analysis of conditional Lrp1-deficient mouse models.

238 perinatal lethality in many of the signaling deficient mouse models.

239 diated gene therapy experiments in dysferlin-deficient mouse models.

240 complex 1(mTORC1) signaling pathway in Phr1-deficient mouse models.

241 apolipoprotein E-deficient, and LDL receptor-deficient mouse models.

242 , we used constitutive and conditional TRPC3-deficient mouse models.

243 ractile and structural phenotypes of nebulin-deficient mouse muscle and human NM-NEB muscle was obser

244 1 also prevented apoptosis in laminin-alpha2-deficient mouse muscle and primary human MDC1A myogenic

245 pha-catulin is reduced in alpha-dystrobrevin-deficient mouse muscle.

246 tiation markers is ablated in both KIF1Bbeta-deficient mouse neuroblasts and human neuroblastomas tha

247 , LPS-induced cytokines from WT and elastase-deficient mouse neutrophils, as well as neutrophils of h

248 On the molecular level, PTPalpha-deficient mouse OPCs and rat CG4 cells have decreased Fy

249 t generation sequencing in wild-type and AID-deficient mouse PGCs at embryonic day (E)13.5.

250 ast, ADAM10 expression was normal on Tspan33-deficient mouse platelets in which Tspan14 is the major

251 rafts was impaired in factor XIII A subunit-deficient mouse platelets, which show impaired clot retr

252 xperiments with alpha(2)beta(1)- or FcRgamma-deficient mouse platelets.

253 lation of Syk and the FcRgamma chain in GPVI-deficient mouse platelets.

254 zed that the effects of insulin in autophagy-deficient mouse primary hepatocytes would be attenuated.

255 BRCA1-deficient mouse primary mammary epithelial cells show lo

256 They now show that an annexin A2-deficient mouse rendered hyperhomocysteinemic by dietary

257 In this study, we show that the Aire-deficient mouse represents a new tool to investigate aut

258 A2a-deficient mouse retina showed defective regulation of ph

259 Histological investigation of WT and Slitrk6-deficient mouse retinas in postnatal development indicat

260 ine in highly purified wild-type and Gtgamma-deficient mouse rod disc membranes.

261 y in individual intact wild-type and Gtgamma-deficient mouse rods was measured by single-cell suction

262 n proceed similarly in wild-type and Gtgamma-deficient mouse rods, but the complex formation between

263 t only IgM from PIV-vaccinated CD4(+) T cell-deficient mouse sera inhibited C. burnetii infection.

264 The PCFT-deficient mouse serves as a model for the hereditary fol

265 t aberrant recruitment of T cells into SOCS1-deficient mouse skin or eye results from abrogation of n

266 -stimulated B220(lo)CD138(+) cells from ELL2-deficient mouse spleens are 4-fold less abundant than fr

267 ascular endothelial cell (VEC)-specific Cx43-deficient mouse strain (VEC Cx43(-/-)) to produce double

268 study its physiological role, we used a gene-deficient mouse strain expressing the bacterial LacZ rep

269 orm-specific PI3K inhibitors and a PI3Kdelta-deficient mouse strain revealed that PI3Kalpha and PI3Kb

270 Here, we have created a new NKT-deficient mouse strain using transcription activator-lik

271 The new Traj18-deficient mouse strain will assist in studies of iNKT ce

272 l outcome of L. major infection in this gene-deficient mouse strain, we analyzed the monocytic compon

273 Taking advantage of a Ptk7-deficient mouse strain, we demonstrate that loss of Ptk7

274 In studies of a CD1d1-deficient mouse strain, we unexpectedly observed a sever

275 for this human pathogen utilizing the SIGIRR-deficient mouse strain, which exhibits significant intes

276 function of Themis2, we generated a Themis2-deficient mouse strain.

277 ing the acrosome reaction using a TPCN1 gene-deficient mouse strain.

278 R-Ras in DC functions, we generated a R-Ras-deficient mouse strain.

279 MC-deficient mouse strains and mice treated with the MC sta

280 ve characterization of different aged immune-deficient mouse strains revealed that T cells significan

281 Infections of Myd88- and TLR7-deficient mouse strains with RRV revealed that both Myd8

282 ling pharmacological inhibitors, genetically deficient mouse strains, and global transcriptome analys

283 cells develops in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id

284 Previous work in the Aire-deficient mouse suggested a role for alpha-fodrin, a ubi

285 raft-versus-host disease (GVHD), wherein NIK-deficient mouse T cells transferred into MHC class II mi

286 ppaB activation and IL-2 production in MALT1-deficient mouse T cells.

287 cue IBNtxA analgesia in a mu-opioid receptor-deficient mouse that lacks all Oprm1 splice variants, ab

288 o the known chromosome 14 translocation, ATM-deficient mouse thymic lymphomas routinely contain a cen

289 he TC-NER pathway, is 10-fold reduced in TR4-deficient mouse tissues, and TR4 directly regulates CSB

290 t galectin-3 is broadly up-regulated in KLF3-deficient mouse tissues, that KLF3 occupies regulatory r

291 containing a large number of introns, in SMN-deficient mouse tissues.

292 Using an MPYS-deficient mouse (Tmem173(<tm1Camb>)), we determined that

293 In this study, we used a sialin-deficient mouse to address how loss of sialin leads to t

294 tore Dp71 expression in Muller cells of Dp71 deficient mouse to study molecular and functional effect

295 The Siglec-G-deficient mouse was also backcrossed to the autoimmune p

296 An Ormdl3-deficient mouse was generated and the role of ORMDL3 in

297 heart disease, whereas an additional kinase-deficient mouse was generated as a control.

298 endothelial cells from an inducible PTP-PEST-deficient mouse, we found that PTP-PEST is not needed fo

299 Using an ME-deficient mouse, we show that ME is required for MLL-AF9

300 Finally, using a MATN-1-deficient mouse, we showed that angiogenesis during frac