ライフサイエンスコーパス: deficit

1 paminergic neuronal system exacerbates motor deficit.

2 ody, suggesting a more generalized attention deficit.

3 object recognition task as a model of memory deficit.

4 a downstream mechanism following peripheral deficit.

5 ues their hippocampal long-term potentiation deficit.

6 atterns associated with autistic-like social deficits.

7 h variations typically associated with brain deficits.

8 w repetitive grooming and social interaction deficits.

9 s toward reducing children's physical growth deficits.

10 important factor underlying these cognitive deficits.

11 ed evidence that obesity can cause cognitive deficits.

12 ments in populations with progressing memory deficits.

13 ted in moderate improvements of sensorimotor deficits.

14 using a frailty index comprised of 47 health deficits.

15 sing new drug target for different cognitive deficits.

16 ron loss, dendritic degeneration, and memory deficits.

17 connectivity that may underlie these hearing deficits.

18 in turn leading to depression and cognitive deficits.

19 aptic F-actin contributes directly to memory deficits.

20 mproved lipopolysaccharide-induced cognitive deficits.

21 av1.3 channels resulted in social behavioral deficits.

22 visual phenotype and the presence of hearing deficits.

23 aged mice was accompanied by spatial memory deficits.

24 is thinking, may contribute to these social deficits.

25 eepiness, depression, anxiety, and cognitive deficits.

26 revent the development of central processing deficits.

27 cognitive assessment resulted in significant deficits.

28 levels of inflammatory cytokines, and memory deficits.

29 combat head trauma-induced chronic cognitive deficits.

30 sing therapeutic approach to treat cognitive deficits.

31 activation, which is associated with memory deficits.

32 lipids, and smoking associate with cognitive deficits.

33 cessive fission and associated mitochondrial deficits.

34 (ID), and frequently presents with attention deficits.

35 tes accounting for these common neurological deficits.

36 ganese levels and parkinsonian-like movement deficits.

37 tivity may mitigate or reverse some of these deficits.

38 ficits (42%) compared with those without any deficits (26%) had worse 6MWD = -109 m (95% confidence i

39 LTx candidates with 2 or 3 muscle deficits (42%) compared with those without any deficits

40 d dibenzoylmethane treatment restored memory deficits, abrogated development of neurological signs, p

41 16)A(+/-) mice showed a significant learning deficit accompanied by reduced spatial map stability and

42 However, diffuse cross-sectional volume deficits across all subfields were found in the more chr

43 priori contrast-based analysis, significant deficits across patient groups (vs controls) were observ

44 durably improves resistant visual attention deficits after brain injury.

45 loss of dendritic spines and rescues memory deficits after TBI.

46 tential therapeutic target to restore memory deficits after TBI.SIGNIFICANCE STATEMENT Traumatic brai

47 p loss produces well-characterized cognitive deficits, although there are large individual difference

48 ncies of chi on temperature, vapour pressure deficit and elevation; and that these same dependencies

49 ical cyclone intensity, the central pressure deficit and the peak near-surface wind speed, is a long-

50 cocaine-exposed sires have memory formation deficits and associated reductions in NMDA receptor-medi

51 isease with patients developing neurological deficits and cardiomyopathy in the long-term, among othe

52 Investigation of neuromuscular deficits and diseases such as SMA, as well as for next g

53 sorder and may lead to their decision-making deficits and excessive worry about everyday problems by

54 mitochondrial fragmentation and distribution deficits and improve mitochondrial function in the CRND8

55 teraction, partly accounted for by cognitive deficits and medication.

56 tes the ischemia-induced brain damage, motor deficits and mortality.

57 pecific cognitive and higher visual function deficits and patients who develop such symptoms early in

58 regulation of a miRNA target and SCZ-related deficits and provide key insights into beneficial LoF mu

59 h drugs were neuroprotective, rescued memory deficits and reduced hippocampal atrophy.

60 omic Ts65Dn mouse model of DS shows synaptic deficits and reproduces the essential cognitive disabili

61 SD) is characterized by social communication deficits and restricted, repetitive patterns of behavior

62 hroughout the brain, leading to intellectual deficits and sensory dysfunction in the fragile X syndro

63 of classic dyslexia, specific comprehension deficit, and language learning disability.

64 nto question the view that motion processing deficits are due to poor reading experience.

65 Although cognitive deficits are one of the factors most strongly associated

66 may not reflect a global sensory-processing deficit, as has often been reported, but rather a tempor

67 evelopment of CAA, negated short-term memory deficits, as assessed by object-recognition tests, and w

68 e in DBN levels is correlated with cognitive deficits associated with ageing and dementia, it was hyp

69 of this process could contribute to various deficits associated with alcohol dependence.

70 logical, neurophysiological, and behavioural deficits associated with Friedreich's ataxia.

71 design of new treatments for the behavioral deficits associated with nutritional n-3 PUFAs' imbalanc

72 ome die or acquire irreversible neurological deficits before they can respond, and relapses can occur

73 was mostly accounted for by processing speed deficit, but this deficit remained when accounting for w

74 eatment of contour irregularities and volume deficits, but the proposed US Food and Drug Administrati

75 ne remodeling that contributes to behavioral deficits by altering synaptic connections, and RhoA-ROCK

76 ibutes to synaptic dysfunction and cognitive deficits by triggering Abeta and Tau accumulation throug

77 CF-related growth deficits can be improved via inhibition of HDAC6, furthe

78 ing and protected mice against the metabolic deficits caused by the consumption of a high-fat diet.

79 R potentiators reduce spatial working memory deficits caused by the nonselective NMDAR antagonist ket

80 e relative change in trait value under water-deficit compared with control conditions.

81 Transgenic mice showed less neurological deficit compared with wild-type mice (n=6).

82 eny in primary roots under control and water deficit conditions simulated by polyethylene glycol trea

83 Significantly, this deficit contributes to the pathophysiology of FXS as the

84 ate [i.e. 35-year mean annual climatic water deficit (CWD)] and competition (i.e. tree basal area) on

85 his treatment prevented pre-synaptic protein deficit, decreased glycogen synthase kinase-3beta (GSK3b

86 may help explain some of the neurocognitive deficits described in these children.

87 compromised during the early stages of motor deficit development.

88 under abiotic constraints such as soil water deficit (drought [D]) and high temperature (heat [H]).

89 , the mass of the surface layer and the mass deficit due to point defects such as impurities and vaca

90 Importantly, neurobehavioral deficits, E/I imbalance, and histological damage are all

91 nsis exhibits exceptional tolerance to water-deficit environments and is therefore an excellent choic

92 er behavioral and nigrostriatal dopaminergic deficits had developed, rats underwent STN-DBS electrode

93 Protein aggregation and axonal transport deficits have been implicated in the disease.

94 ts circuit reorganizations and gap detection deficits, highlighting the potential for using sound the

95 th autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and schizophrenia

96 psychiatric conditions, including attention deficit hyperactivity disorder (ADHD) and substance use

97 mixed on the relationship between attention-deficit hyperactivity disorder (ADHD) and younger relati

98 to the adult outcome of childhood attention deficit hyperactivity disorder (ADHD) could guide novel

99 ive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD).

100 cluding schizophrenia, depression, attention-deficit hyperactivity disorder and substance abuse disor

101 f monozygotic twins discordant for attention deficit hyperactivity disorder can elucidate mechanisms

102 tes under clinical development for attention deficit hyperactivity disorder, binge eating disorder, c

103 mg/kg, IP) dose-dependently ameliorated PPI deficits, hyperactivity, and risk-taking behaviors, in a

104 disorder (94.2 [1.69]; P = .004), attention-deficit/hyperactivity disorder (96.3 [0.91]; P = .002),

105 Attention-deficit/hyperactivity disorder (ADHD) affects 39 million

106 Attention-deficit/hyperactivity disorder (ADHD) and bipolar disord

107 as long been effective in treating attention-deficit/hyperactivity disorder (ADHD) and is currently t

108 demonstrated that individuals with attention-deficit/hyperactivity disorder (ADHD) are more likely to

109 Attention-deficit/hyperactivity disorder (ADHD) diagnosis is based

110 utism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occu

111 Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly

112 c differences were associated with attention-deficit/hyperactivity disorder (ADHD) in a recent multi-

113 Attention-deficit/hyperactivity disorder (ADHD) is associated with

114 Attention-deficit/hyperactivity disorder (ADHD) often persists int

115 er understand the underpinnings of attention-deficit/hyperactivity disorder (ADHD), we targeted the r

116 between atopic dermatitis (AD) and attention-deficit/hyperactivity disorder (ADHD).

117 isting attention problems, such as attention deficit/hyperactivity disorder (ADHD).

118 isk genes have been identified for attention-deficit/hyperactivity disorder (ADHD).

119 ysfunction of which is a factor in attention-deficit/hyperactivity disorder (ADHD).

120 (HR, 0.83 [95% CI, 0.62-1.13]), or attention-deficit/hyperactivity disorder (HR, 0.99 [95% CI, 0.79-1

121 Some conditions, such as attention-deficit/hyperactivity disorder and inpatient well-newbor

122 reatment of insomnia [sleep aids], attention-deficit/hyperactivity disorder drugs, antidepressant dru

123 io [HR], 2.02 [95% CI, 1.80-2.26]; attention-deficit/hyperactivity disorder HR, 2.21 [95% CI, 2.04-2.

124 e and inpatient well-newborn care, attention-deficit/hyperactivity disorder, and asthma among all con

125 disorders in offspring, including attention deficit/hyperactivity disorder, autism, and schizophreni

126 hem and schizophrenia, depression, attention-deficit/hyperactivity disorder, eating disorders, autism

127 or after the exclusion of comorbid attention-deficit/hyperactivity disorder.

128 w for Prodromal Syndromes, and for attention-deficit/hyperactivity, substance-related, and mood disor

129 several studies failed to induce performance deficit implementing this approach.

130 There was a 30% deficit in (18)F-FDG concentration, which was restored b

131 ation aims to precisely quantify the process deficit in anxious individuals and determine the degree

132 y, it is important to estimate any resulting deficit in biodiversity and functions.

133 eeks of intensified training and mild energy deficit in elite race walkers increases peak aerobic cap

134 emoval of auditory cortex PNNs resulted in a deficit in fear learning and consolidation.

135 The identification of a molecular deficit in HSP in Mecp2 KO neurons provides potentially

136 This deficit in HSP is bidirectional because Mecp2 KO neurons

137 ) in the NAc core, TLR4.KO animals exhibit a deficit in low-frequency stimulation-induced NMDAR-depen

138 mster prion strain 263K suffer from a severe deficit in mitochondrial oxygen consumption in response

139 riminate and evaluate the severity of myelin deficit in mouse and rhesus monkey brains.

140 Notably, we identified a pronounced deficit in neuronal adaptation to repetitive whisker sti

141 ool for identification and evaluation myelin deficit in preclinical animals and potentially in para-c

142 Unexpectedly, DeltaXX showed no deficit in replication in vivo in a variety of tissues a

143 ic protein alterations are associated with a deficit in the ability of cerebellar neurons to form syn

144 causes a stimulus-specific and long-lasting deficit in the ability of the conditioned stimulus to be

145 f extracellular d9-choline uptake revealed a deficit in the amount of d9-choline found inside NECL4-d

146 tonomic neuropathy is an early and prominent deficit in the db/db model and have implications for the

147 th the extent of the peripheral visual field deficit in this cohort.

148 SF1 prevents neurodegeneration and locomotor deficits in a Drosophila model of C9ORF72-related diseas

149 However, the mechanism underlying lysosomal deficits in AD remains poorly understood.

150 lating Abeta levels and attenuating synaptic deficits in AD.SIGNIFICANCE STATEMENT beta-Site amyloid

151 risomy 21 contribute significantly to memory deficits in adult life in DS.

152 of such reorganization events during sensory deficits in adulthood.

153 to be responsible for a range of perceptual deficits in amblyopic humans, the neural basis for the e

154 asing brain p62 expression rescues cognitive deficits in APP/PS1 mice, a widely used animal model of

155 of Nrf2 significantly exacerbates cognitive deficits in APP/PS1, without altering gross motor functi

156 uction, which could contribute to behavioral deficits in AS, including motor dysfunction.

157 targeted therapies to help ameliorate social deficits in autism spectrum disorder.

158 e PFC, these alterations could contribute to deficits in behavioral control and decision-making in ad

159 s to and worsens the overall oxidative burst deficits in CF MDMs compared with non-CF MDMs.

160 gs effectively attenuate neural and vascular deficits in chronic and acute mouse models of CCM3 loss

161 Tobacco withdrawal is associated with deficits in cognitive function, including attention, wor

162 rmittent seizures drive persistent cognitive deficits in conditions accompanied by recurrent seizures

163 Diabetic patients experience functional deficits in dark adaptation, contrast sensitivity, and c

164 ns by determining the pathways through which deficits in EAP affect functioning would suggest when an

165 severe hyperglycemia along with significant deficits in echocardiographic measurements.

166 ) reduced in schizophrenia and 2) related to deficits in executive function.

167 om patients treated with bisphosphonates had deficits in fracture toughness, with lower crack-initiat

168 hough previous studies suggest glutamatergic deficits in fronto-striatal brain areas in both disorder

169 ld partially explain the auditory processing deficits in FXS.

170 underlying cause of the auditory processing deficits in FXS.SIGNIFICANCE STATEMENT Fragile X Syndrom

171 A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-compulsi

172 prefrontal cortex reverses social dominance deficits in Grn+/- mice, an animal model of frontotempor

173 synapse, which may contribute to perceptual deficits in hearing.

174 ong-term potentiation (LTP), consistent with deficits in hippocampus-mediated behaviors.

175 ubstance use disorders, are characterized by deficits in impulse control, however the relationship be

176 rt inhibitor ALX5407 in the vmPFC alleviated deficits in impulse control.

177 sms of disease leading to neurodevelopmental deficits in infected infants remain undefined, but postu

178 ing barrel cortex neurons, and that eventual deficits in inhibition may have differential effects on

179 Behavioral deficits in integrating complex audiovisual stimuli in h

180 a constitutively active Rac3 can rescue the deficits in invadopodium function in Vav2-knockdown cell

181 We propose that deficits in IP3-mediated Ca(2+) signaling represent a co

182 age < 10 years at diagnosis are at risk for deficits in IQ and PS in the absence of cranial radiatio

183 d with controls, monkeys with VS lesions had deficits in learning to select rewarding images but not

184 anfilippo syndrome, MPS IIIA-D, results from deficits in lysosomal enzymes that specifically degrade

185 been associated with cognitive and emotional deficits in mental illnesses.

186 e and rescues both neurogenic and behavioral deficits in mice lacking TrkB.

187 we were not able to identify any functional deficits in mutations I814T, D933N and N976S located bet

188 Deficits in neurite density appear fundamental to abnorm

189 f-function is a possible cause of motivation deficits in neurodegenerative diseases.

190 Moreover, finding no RC deficits in offspring of BD patients suggest a different

191 We also observed similar deficits in organoids derived from schizophrenia patient

192 ghly effective symptomatic therapy for motor deficits in Parkinson's disease (PD).

193 Indeed, depression often precedes cognitive deficits in patients with AD.

194 egration and organization and thus cognitive deficits in patients with PD.

195 Model-predicted deficits in PEEP-dependent lung recruitment correlate wi

196 Given significant deficits in quality of care, reforms encouraging first c

197 need to address manpower and infrastructural deficits in RI service delivery through the BPHS program

198 n of NMDAR hypofunction to predictive coding deficits in schizophrenia.

199 Functional deficits in sensory systems are commonly noted in neurod

200 ted to a transdiagnostic continuum of reward deficits in specific neural networks.

201 , partial hearing loss can produce prolonged deficits in speech perception and temporal processing.

202 Anxiety is linked to deficits in structural and functional connectivity betwe

203 with frequent exposure to loud music exhibit deficits in suprathreshold auditory performance consiste

204 pathy in Tau-P301S mice but also rescues the deficits in synaptic integrity and plasticity.

205 Furthermore, stress-induced deficits in synaptic proteins and decreases in dendritic

206 Findings indicate that deficits in thalamocortical, as well as corticocortical,

207 nses and elicits TS-like sensorimotor gating deficits in the D1CT-7 mouse, one of the best-validated

208 lacentation defects, which result from major deficits in the decidualisation response of the uterine

209 , these findings support the idea that spine deficits in the DLPFC may contribute to subcortical hype

210 These impairments likely reflect deficits in the maintenance of memory representations, n

211 imary cause of pathology, leading to further deficits in the mitochondrial axonal transport and onset

212 ese changes remain unclear, although genetic deficits in the molecular clock regularly render mice wi

213 Mutant mice showed deficits in the novel object recognition task, suggestin

214 rosopagnosia (DP) is characterised by severe deficits in the recognition of faces, which the many-to-

215 Deficits in the salience network suggest an impaired abi

216 Prefrontal-dependent deficits in the spatiotemporal coordination of NREM slee

217 d impaired sparse coding of information, and deficits in the temporal tuning of neural activity and i

218 plays a crucial role in development and that deficits in this ability may be the reason why preterm i

219 ociations of childhood blood lead level with deficits in verbal comprehension and processing speed we

220 However, the observed cognitive deficits in victimized individuals were largely explaine

221 ese analyses further revealed a continuum of deficits in which BPD showed intermediate levels of CC r

222 Experiment 3 revealed selective deficits in WM contributions and preserved RL value lear

223 ionately reduced in AS mice, indicating that deficits in WM development are a major factor underlying

224 al mechanism through which hypoxia may cause deficits in working memory.

225 in novel object recognition and less severe deficits in Y-maze behaviors.

226 To address this deficit, in the present study, we established an in vitr

227 A1/A2 AMPARs in the NAc core mediated social deficits, independent of S831-GluA1 phosphorylation.

228 hancing properties and it ameliorated memory deficits induced by scopolamine.

229 The deficit irrigation treatment significantly increased pol

230 relationship between the effect of regulated deficit irrigation, cluster, developmental stages and tw

231 The deficit is rescued by selectively elevating levels of 2-

232 specific adverse outcomes such as behavioral deficits is a possibility that merits further investigat

233 in cognitive function from cannabis-induced deficits is challenging.

234 Neurovascular deficits lead over time to impaired neuronal excitabilit

235 The data support a model in which EAP deficits lead to poor functional outcome via impaired co

236 A-tdTHz, we evaluated the severity of myelin deficit lesions in rhesus monkey brain induced by experi

237 Comparisons between number of muscle deficits (low muscle mass, quadriceps strength and physi

238 effects of BAY against Abeta-induced memory deficits might involve the regulation of neuroinflammati

239 ndom drift; predicted effects include energy deficit, muscle weakness, anomalies in cranial and skele

240 To examine whether the general cognitive deficit observed across psychotic disorders is similarly

241 actor contributing to the neurodevelopmental deficits observed in ASD.

242 s much effort with little benefit, through a deficit of ACC dopamine release triggered by high-effort

243 Disorders of water balance, an excess or deficit of total body water relative to body electrolyte

244 this study, we characterized the functional deficits of AIPL1 variations, some of which induce aberr

245 ently and robustly associated with cognitive deficits of ASD and ID in humans, and overexpression of

246 ivities and corrects the synaptotoxicity and deficits of axonal transport induced by Abeta.

247 In addition, acquired deficits of multiple Ca(2+)-handling proteins can contri

248 Early detection of the behavioural deficits of neurodegenerative diseases may help to descr

249 ion in human cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mouse co

250 DDC gene, bas-1, ameliorated the behavioral deficits of tau transgenic worms, reduced phosphorylated

251 SZ offspring were found to show connectivity deficits of the brain's central rich club (RC) system re

252 Volume deficits of the hippocampus in schizophrenia have been c

253 category score of 1 (mild or no neurological deficit) or 2 (moderate cerebral disability) was conside

254 potential, soil moisture, and vapor pressure deficit over 2 yr in the Northern Rocky Mountains, USA.

255 tical stroke often leads to persistent motor deficits, prompting the need for more effective interven

256 ve function was assessed using the Perceived Deficits Questionnaire (PDQ).

257 ) drove akinesia, whereas movement execution deficits reflected the ratio of AMPARs in D2 versus D1 c

258 respect to social communication and language deficits relative to those with ASD with no identified g

259 ed for by processing speed deficit, but this deficit remained when accounting for working memory (Coh

260 ons (i.e. hypervigilance and impulse control deficits, respectively).

261 these neurons can compensate for behavioral deficits resulting from midbrain dopamine dysfunction.

262 The behavioral and anatomical deficits seen in fragile X syndrome (FXS) are widely bel

263 y lentiviral RNA interference reproduced the deficits seen in P311(-/-) mice.

264 n-deficient lines developed social dominance deficits similar to those in global Grn+/- mice, showing

265 ol conditions, 106 were detected under water-deficit stress, and 76 were detected for trait plasticit

266 thought to give rise to auditory perception deficits such as temporal processing impairments, hypera

267 er from a larger open circuit voltage (VOC ) deficit than narrower bandgap ones.

268 Patients with a clinical deficit that is disproportionately severe relative to th

269 eukemia (ALL) are at risk for neurocognitive deficits that are associated with treatment, individual,

270 ain and underlie the mPFC-specific cognitive deficits that are comorbid with neuropathic pain.SIGNIFI

271 he authors demonstrate that axonal transport deficits that are observed in these cells can be rescued

272 patients with kidney disease have olfactory deficits that may influence their nutritional status.

273 5 despite the profound vestibular functional deficits that persist with treatment at this later time.

274 ividuals were largely explained by cognitive deficits that predated childhood victimization and by co

275 Schizophrenia is associated with cognitive deficits that reflect impaired cortical information proc

276 and related agonists for treating cognitive deficits, these data suggest that daily dosing may be cr

277 ases in oxidative damage and cellular energy deficits; these, in turn, impair mitophagy.

278 - and high-yielding regions, the contributed deficit to national production caused by increasing temp

279 ion of alphaLNNd can overcome polymerization deficits to increase laminin, stabilize BM structure, an

280 y more stable to expression changes by water deficit treatment than other genotype-specific expressio

281 We addressed this deficit using principles of receptor silent substitution

282 The increased locomotor deficit was associated with specific reduction in striat

283 al gap detection thresholds (GDTs), but this deficit was fully reversed by three 1 h sessions of expo

284 mice compared to control db/+ mice and this deficit was greater compared to reductions in intraepide

285 In schizophrenia, working memory deficit was mostly accounted for by processing speed def

286 58F, hDAT-G327R, and hDAT-L368Q, the folding deficit was remedied with the pharmacochaperone noriboga

287 Acclimation to water deficit (WD) enables plants to maintain growth under unf

288 The memory deficits we observed in mouse prion disease were complet

289 e to spatial and temporal variation in water deficit, we analyze data from three forest dynamics plot

290 To address this deficit, we generated samples of a wild-type GPCR (A2AR)

291 NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injecti

292 d that annual rainfall and accumulated water deficit were the main drivers of the distribution of tre

293 These deficits were accompanied by pronounced hippocampal atro

294 Finally, PPI deficits were exacerbated by allopregnanolone (10 mg/kg,

295 Life expectancy gains and deficits were further disaggregated by age and cause of

296 Deficits were largely restricted to visual decisions.

297 orsened by a mean (SD) 2.5 (1.9) points, and deficits were limited to a single NIHSS item in 62 episo

298 that RTT-derived neurons have many cellular deficits when compared to control, such as: less synapse

299 Lentiviral transfer of P311 corrected the deficits, whereas down-regulation of P311 levels by lent

300 ether these changes are related to cognitive deficits, which have been described in ET patients.