ライフサイエンスコーパス: define

1 nd improve survival for patients is not well defined.

2 aintenance, but the ligands involved are ill-defined.

3 portant genome characteristics have not been defined.

4 ere isolated to homogeneity and structurally defined.

5 ontrol of M. tuberculosis have not been well defined.

6 inflammatory vascular diseases are not well defined.

7 indications and mechanisms remain partially defined.

8 ation-prone asthma (EPA) remain incompletely defined.

9 efractory to standard treatments is not well defined.

10 pinning coronary artery formation remain ill-defined.

11 ation of leukotoxin production have not been defined.

12 novel substrate specificities are not wholly defined.

13 erlie breast epithelial hierarchy remain ill-defined.

14 well understood, its regulon remains poorly defined.

15 llular serotonin levels in vivo are not well-defined.

16 ways that regulate their development are ill defined.

17 atic ductal adenocarcinoma (PDAC) are poorly defined.

18 mediate this protective effect remain poorly defined.

19 ccuracy of preoperative 4D-CTs remain poorly defined.

20 sociated immunosuppression in humans are ill-defined.

21 Our analysis defines 96 genomic regions recurrently targeted by homoz

22 ely 2.2% of patients with metastatic CRC and define a clinically distinct subtype of CRC with an exce

23 Collectively, we define a new axis for thymic emigration involving stimul

24 These results define a new component of the signaling network by which

25 direct regulator of cardiac hypertrophy and define a new paradigm of gene regulation in the heart, w

26 tions 206, 281, and 284 of the STING protein define a novel cluster of amino acids with functional im

27 n summary, the piRNA-rich nict-1 locus could define a novel mechanism underlying phoretic interaction

28 d in acutely restimulated CD8(+) T cells, we define a pattern of chromatin accessibility specific for

29 Our results thus define a specific requirement for primary cilia-mediated

30 some 13, which encompassed the Bhmt gene and defined a potentially sensitive region with mostly decre

31 and control in 264 475 population subgroups-defined a priori by all possible combinations of 11 demo

32 Metabolic syndrome defines a cluster of interrelated risk factors for cardi

33 c profiling of cilia from diverse eukaryotes defines a conserved ciliary proteome, reveals ancient co

34 This study therefore defines a novel mechanism of MAPK activation requiring b

35 Thus, Mex3a defines a reserve-like ISC population within the Lgr5+ c

36 stable disease, and progressive disease were defined according to the 2014 National Institutes of Hea

37 ruct simple peptides that assemble into well-defined amyloid phases and define paracrystalline surfac

38 We aimed to define an association between mtDNA and fibroblast respo

39 e correlations of CO2 with trace elements to define an average carbon abundance for the upper mantle.

40 We define an environmental potential landscape from environ

41 We define an IEC transcriptional regulatory network that is

42 A secondary analysis loop in EoE patients defined an IGHE score of >/=37.5 for a patient subpopula

43 rmalized dual-marker analysis can be used to define "analytical zones" in a manner which is then inde

44 dies reveal a complex molecular network that defines and restricts pluripotent developmental potentia

45 roperties of adipocyte precursors can now be defined, and the regulation and function of adipose plas

46 The functions of many RBR E3s are poorly defined, and their regulation is complex, involving post

47 es in intestinal microbiota are necessary to define applicability of new strategies targeting the int

48 y constant over time, and as new species are defined, appropriate discriminatory tests may not be pre

49 ach to eliminate malaria from geographically defined areas.

50 the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants

51 MR was defined as >/= mild regurgitation on color Doppler in FH

52 Stages were defined as (1) number of people living with HIV in the c

53 We analysed linkage to care at 6 months (defined as 1-LTFU) as the primary outcome.

54 Amyloid-positivity was defined as 11C-Pittsburgh compound B target-to-cerebella

55 BCR was defined as 2 consecutive prostate-specific antigen rises

56 Treatment success was defined as a 50% or greater reduction in pain frequency

57 Severe obesity was defined as a body-mass index (BMI, the weight in kilogra

58 An exacerbation was defined as a burst of systemic corticosteroids lasting 3

59 Moderate disability was defined as a cognitive score of 70 to 84 and either GMFC

60 Defined as a diagnosis of Crohn's disease, ulcerative co

61 Disagreement was defined as a negative symptom report or no mention of a

62 d 6 kHz) were computed, and hearing loss was defined as a PTA>25 dB in adults and PTA>15 dB in adoles

63 High cIMT was defined as a study-specific value >/=90th percentile.

64 ecorded; serum creatinine (Cr) at day 90 was defined as baseline.

65 Poor visual outcome was defined as BCVA of worse than 20/40.

66 Islet autoimmunity and CD autoimmunity were defined as being positive for islet or tissue transgluta

67 smural extent of infarct (TEI) of </=50% are defined as being viable.

68 11,449 reliable visual fields (VFs) that are defined as clinically unaffected based on summary indice

69 Overall response will be defined as complete response, partial response, minor re

70 ich was testing completeness within 30 days, defined as completion of three required tests and their

71 he same molecular markers from days 8 to 42 (defined as cure).

72 Unsuccessfully treated hypertension was defined as daytime ambulatory BP of at least 135/85 mm H

73 A gene can be defined as essential when loss of its function compromis

74 bgroup with optimal CVRFs (n = 740) was also defined as having blood pressure <120/80 mm Hg, fasting

75 The success criterion was defined as IOP </= 12 mm Hg without and with antiglaucom

76 Food deserts (FD), neighborhoods defined as low-income areas with low access to healthy f

77 n algorithm for global cognitive impairment (defined as Mini Mental State Examination [MMSE] </=25) u

78 ysical injury, evidence of anatomical injury defined as minor by an injury severity score between 2 a

79 PCR-CI was defined as molecular diagnostic evidence of influenza vi

80 analyses of baseline and 24 h CTs, with dIVH defined as new intraventricular haemorrhage (IVH) on the

81 main outcome was self-reported incident CVD, defined as new myocardial infarction, angina pectoris, o

82 amples analyzed, 73% were positive for KLF5 (defined as nuclear staining in more than 5% of tumor cel

83 Allergic rhinitis (AR) was defined as one or more positive results on skin prick te

84 Mild hyperoxia was defined as PaO2 between 120 and 200 mm Hg; severe hypero

85 Vitamin B-6 deficiency was defined as PLP <20 nmol/L, and insufficiency as PLP 20-3

86 ed within the CD45RA(-) fraction and further defined as positive for CD26 in combination with an aber

87 ion of moderate or severe vision impairment (defined as presenting visual acuity of <6/18 but >/=3/60

88 Early fluoroquinolone (FQ) use was defined as receiving >/=5 doses during the first month o

89 was the time to recovery of kidney function defined as return of postintervention creatinine level t

90 airment in activities of daily living (ADL) (defined as severe or moderate to severe) for adults aged

91 A case was defined as signs or symptoms of botulism in a prison A i

92 h adult patients with adult-onset of asthma (defined as starting at age >/=18 years) as compared with

93 It is defined as the area under the P rofile of S hannon D iff

94 Floors were defined as the average image area with a loss less than

95 A cascade is defined as the combination of at least two reaction step

96 CVD, which combines coronary heart disease, defined as the first incident myocardial infarction or d

97 owing to coronary heart disease, and stroke, defined as the first nonfatal stroke or death owing to s

98 A severe critical event was defined as the occurrence of respiratory, cardiac, aller

99 Dual-task gait cost was defined as the percentage change between single- and dua

100 Accuracy was defined as the percentage of LDL-CD falling within an es

101 Cardiac arrest is defined as the termination of cardiac activity associate

102 GNIFICANCE STATEMENT Neurovascular coupling, defined as the tight relationship between activated neur

103 e 3 stage of the trial was overall survival (defined as the time from randomisation until death from

104 scale score of 0 to 2 (</=50% hair loss) was defined as treatment success.

105 Celiac disease was defined based on detection of Marsh 2 or greater lesions

106 Kappa = 0.424) was observed between hotspots defined based on parasite prevalence by polymerase chain

107 ing that the malignant nature of the DCIS is defined before invasion.

108 elded new nanoscale materials with precisely defined biochemical features, and emerging analytical te

109 r adducts provides the desired geometrically defined bis-acenes.

110 ilter conformation, which play a key role in defining both selectivity and permeation.

111 ive stress response miRNA whose activity may define breast cancer progression and survival.

112 es and GTP-bound GTPases, which provide well-defined but mutable labels.

113 y A. baumannii to cause disease are not well defined, but recent research has indicated that secreted

114 Progression of subclinical CVD was defined by 10-year change in left ventricular structure

115 omyosin in a blocked-state position on actin defined by a deeper energy minimum, consistent with augm

116 Infective endocarditis is defined by a focus of infection within the heart and is

117 and other neurodegenerative conditions, are defined by a pathological hallmark: neurofibrillary tang

118 Advanced chronic kidney disease was defined by a sustained reduction in eGFR less than 30 mL

119 ore between 2 and 8 and normal physiology as defined by a triage-Revised Trauma Score of 12.

120 ration of human natural killer (NK) cells as defined by accumulation of cell-surface expression of CD

121 Preexisting HF was defined by any HF encounter during the first year, and i

122 We investigated whether subspecies of HDL defined by apoC-III are associated with coronary heart d

123 h energy parameter set results in ten models defined by centers of highly populated clusters of low-e

124 h primary progressive aphasia (PPA) variants defined by current diagnostic classification.

125 ection as the outcome and vaccination status defined by days between vaccination and symptom onset as

126 tatic cells as two distinct cell populations defined by differential expression of 412 genes and of m

127 selective for the orientation of boundaries defined by first-order cues (luminance) as well as secon

128 Cardiac arrest in this study was defined by intra-aortic pressure monitoring that is not

129 stages of protein folding, which are likely defined by intrinsic local interactions between amino ac

130 riant NKT (iNKT) cell functional subsets are defined by key transcription factors and output of cytok

131 classic BCR-ABL1(-) MPNs, which are largely defined by mutations in JAK2, CALR, or MPL In the B-cell

132 l, deep-incisional, and organ-space SSIs, as defined by NSQIP.

133 bnormal versus healthy vaginal microbiota as defined by Nugent score.

134 Remission was defined by symptom improvement and less than 15 eosinoph

135 Adjudicated severe hypoglycemia, as defined by the American Diabetes Association, was the pr

136 SPOP(MT);MYC(High) transcriptomic response, defined by the overlap between the SPOP(MT) and c-MYC tr

137 .7 (Medisoft, Leeds, United Kingdom) and was defined by the presence of at least 2 adjacent testing p

138 In this model, a loop defined by the SCI's B and C domains encircles the C-ter

139 obility, and sharp absorption edges that are defined by the twisted molecular conformation.

140 d across distinct cortical regions have been defined by their morphological, electrophysiological, an

141 Synaesthesia is defined by unusual sensory experiences and has also been

142 ia was conducted using a CD19 CAR product of defined CD4/CD8 composition, uniform CAR expression, and

143 ta peptide (Abeta) into amyloid fibrils is a defining characteristic of Alzheimer's disease.

144 n CD34(+) hematopoietic progenitor cells, we defined classes of low to moderately expressed genes tha

145 We define conditions under which the economically optimal p

146 mputations, but how synapses of functionally defined cortical networks are arranged within the dendri

147 h increased SR luminal Ca(2+) These findings define critical roles for Stac3 in EC coupling and human

148 However, in the embryo and in defined culture environments the properties of pluripote

149 ere we infer the potential impact of 19 well-defined DCAFs in human lung adenocarcinomas (LuADCs) usi

150 radients in fluid systems with initial, well-defined density gradients results in the formation of di

151 Two groups ( n = 60) were defined depending on the type of prosthetic restoration

152 fication was based on applying five strictly defined diagnostic characteristics (eccentric hilum, lon

153 These results define direct structural roles for yeast CAF-1 subunits

154 y using single-channel current recording, we define discrete assembly intermediates and show that the

155 pecific roles for p100 and p105 signaling in defining DLBCL molecular subtypes and posit MYD88/p100 s

156 show that mobile small RNAs generate sharply defined domains of target gene expression through an int

157 e albumin are independently folded into well-defined domains separated by a flexible linker.

158 g regime, we report the existence of clearly defined dynamic localized regions of substantially incre

159 chemical reaction networks (CRNs) with well-defined dynamic properties.

160 ese data reveal a unique molecular code that defines endogenous proteins as inflammatory stimuli by m

161 Although no single feature defines EoE, a constellation of compatible demographic,

162 present, each existing platform relies on a defined exogenous transcription activator capable of bin

163 (NMBA) panels and 17/44 (39%) lacked a NAP6-defined extended panel; many failed to screen all cases

164 We therefore defined eyes as having early tears if they tore before t

165 er utilization, but more work is required to define factors predicting good outcomes.

166 nts between the nucleus and cytoplasm is the defining feature of eukaryotic life.

167 The defining feature of PITPs is their ability to exchange p

168 ponents of the host innate immune system and define first-line of defence against pathogens.

169 ce for sensory modality, vision or audition, defines four discrete LFC regions.

170 oglobulin G (IgG) were fabricated using well-defined full-length antibody-polymer conjugates (APCs).

171 ysis to perform gene set analysis using data-defined functional gene signatures.

172 MET-induced defects in anatomy result in defined functional lesions in the larval heart, implicat

173 olog of the stomatal regulator AtMUTE, which defines GC precursor fate in Arabidopsis The novel role

174 We have defined genetic markers able to segregate stable HIV-1-c

175 Similarly, the procurement of defined glycans is key to establishing structure-activit

176 e detectable with 12 subjects in each of two defined groups.

177 The Oxford Dictionary of English defines habit as "a settled or regular tendency or pract

178 A defining hallmark of primary and metastatic cancers is t

179 be further sorted to produce nanotubes with defined handedness, helicity, and endohedral filling.

180 ed assays for novel biomarkers toward better defining hepatitis B virus cure should occur in parallel

181 On ultrasound, there were well-defined, heterogeneous, predominantly hypoechoic, round-

182 e viral strains that engage them, as well as defined how such antibodies mature to acquire breadth.

183 Four treatment groups were defined: hyperthermia, ablation, hyperthermia followed b

184 While AIDS-defining illnesses were relatively rare, non-AIDS-defini

185 RW was defined in several ways, with the main definition being

186 The Milan criteria were originally defined in the context of adult liver transplantation fo

187 ns of thousands of A-to-I editing events are defined in the mouse, yet the functional impact of most

188 Ecoinformatics, as defined in this review, is the use of preexisting data s

189 We defined incident CKD as eGFR<60 ml/min per 1.73 m(2) and

190 ing illnesses were relatively rare, non-AIDS-defining infection hospitalizations were more common.

191 hics, feeding, and illness were collected at defined intervals.

192 y 200 nm) ionophore-based polymeric films of defined ion-exchange capacity have recently emerged as a

193 ystal structure of the MOB1/NDR2 complex and define key MOB1 residues mediating MOB1's differential b

194 ive network analysis, and functional studies define landscapes of the T cell proteome and phosphoprot

195 ints to the existence of multiple, less well-defined layers of regulation.

196 Structural studies of the beta1AR define ligand-binding sites in the transmembrane helices

197 d by lagging-strand synthesis by a yet to be defined mechanism.

198 Small molecules with novel and defined mechanisms of inhibition are thus needed to func

199 n abolish Pseudomonas aeruginosa growth in a defined medium with malonate as the sole carbon source.S

200 water per day, the water group received well-defined messages about water through counseling and dail

201 rthogonal systems and the generation of well-defined microenvironments can be used to develop novel d

202 vided insights into their regulatory role in defined modules of the JA network.

203 Defining mutation load in individual pancreatic cancers

204 Analysis of HIV-1 isolates bearing defined mutations in the capsid protein revealed differe

205 The anatomically defined neuron classes connecting the AOTU, BU, and EB r

206 Two clinical trials to define novel ways of using an existing antibiotic, fosfo

207 quences of laparoscopic surgery as well as a defined operative plan generated by a multidisciplinary

208 ssemble into well-defined amyloid phases and define paracrystalline surfaces able to catalyse specifi

209 value, it harbours shortcomings such as ill-defined parameters for subtypes and grading criteria pro

210 the vertebral bodies on T2 TIRM images, well-defined paraspinal abnormal contrast enhancement, parasp

211 The opposed defined-pathway model stems from experimental results th

212 A well-defined Pd(II)-peroxo complex is a competent intermediat

213 ally differentiated human counterparts using defined phenotyping, to make sure the cells are relevant

214 ay for regulation of beta-catenin levels and define PKC as an important beta-catenin interaction part

215 We defined polymorphism of Papa-B, the bonobo ortholog of H

216 the anatomical composition of a genetically defined population of balance interneurons in the larval

217 acterize the functional contributions of Cre defined populations.

218 lses can generate single skyrmions at custom-defined positions in a magnetic racetrack deterministica

219 lity of RNAs containing this modification at defined positions that can be used for in vitro studies

220 compatible with producing radical cations at defined positions within DNA.

221 s between the two WEs were recorded across a defined potential spectrum (between -1V and +0.5V vs. Ag

222 the waiting group (n = 147) in the following defined primary study outcomes: coping behavior with res

223 The template is precisely defined, processively copied, and regenerated by release

224 lthough larger studies are needed to further define program factors affecting attrition.

225 maging to measure BOLD activity at precisely defined receptive field locations in visual cortex (V1)

226 licular regulatory T (TFR) cells are a newly defined regulatory T cell (Treg) subset that suppresses

227 is context, we consider the complex topic of defining resolution for this imaging modality and addres

228 A well-defined risk factor and precursor for cutaneous melanoma

229 Our study defines RNF8 and UBC13 as components of a novel cytoplas

230 d that UL37 plays an essential albeit poorly defined role in intracellular capsid trafficking.

231 ermanently misfolded protein, two previously defined roles for Sse1.

232 To better define serum inflammatory and cardiovascular risk protei

233 born neurons, revealing that developmentally defined sets of neurons may differentially participate i

234 We defined severe mental illness as a clinical diagnosis of

235 Children had World Health Organization-defined severe or very severe pneumonia or were age-freq

236 ignificant trend toward lower rates of GUSTO-defined severe/life-threatening bleeding with cangrelor

237 culty of isolating certain types of cells at defined stages of in planta development for in-depth ana

238 and MYC may present a novel and molecularly defined strategy to target mutant p53 in pancreatic canc

239 idue sequence element also turns into a well-defined structural element upon fibril formation.

240 using a literature search and prospectively defined study selection, we sought systematic reviews, m

241 aining HIV-1 transmission and contributes to defining subsequent AIDS pathogenesis.

242 Mapping neural circuits across defined synapses is essential for understanding brain fu

243 Together, these experiments define synaptic dysfunction at NMJs experiencing ALS-rel

244 isk for short-term development of clinically defined synucleinopathy.

245 ete and gradual transcriptional changes that define T cell development.

246 To better define the binding site, we used a series of decoy pepti

247 used cellular expression profiling tools to define the distinct miRNA expression of MNs, which is li

248 This study's aim was to define the effects of these mediators on neutrophil func

249 hibiting milder cell loss in PD, we aimed to define the electrophysiological properties of DMV neuron

250 ator of elevated NOTCH signaling in BTIC and define the establishment of a TN-alpha2beta1-JAG1-NOTCH

251 otection from or risk of disease but also to define the functional roles these genes play in disease.

252 cale single-cell gene expression analysis to define the heterogeneity within the LSC population in ch

253 Prospective studies are needed to define the impact of pretransplant sensitization on lung

254 To define the interplay between the carbohydrate receptor a

255 ation assays, and genetic lineage tracing to define the lineage relations and restrictions of the mes

256 In this study, we aimed to define the mechanisms by which noninflammatory SF modula

257 Tfh cells in germinal centers to explicitly define the mechanisms of selection in this complex evolu

258 Here we define the minimal requirements for TCR antigen specific

259 Our results define the molecular and neural pathways through which p

260 -WDR33 subcomplex and biochemical assays, we define the molecular architecture of the core human CPSF

261 sphoproteomics, and Western blot analysis to define the necessity of various proteins involved in Sig

262 vitro analysis using TC10-deficient mice, we define the poorly studied Rho GTPase TC10 as an immunomo

263 To define the relative contribution of endogenous TGF-beta

264 and high resolution electron microscopy can define the subunit topology and copper binding of a mang

265 Studies to define the temporal requirements for Glut1 reveal that p

266 Here we define the Xist RNA Polycomb Interaction Domain (XR-PID)

267 Using this panel, we have largely defined the carbohydrate specificities of each PTS trans

268 with three proteases and sequencing de novo defined the complete protein sequence and located an Ala

269 Although the tissue of residence defined the core signature of macrophages, phagocytosis

270 Importantly, we defined the repertoire of pollen tube-secreted proteins

271 is and molecular dynamics simulation studies defined the sequence of the NDSM as Psi-K-x-E/D-x1-x2-(x

272 Our work defines the pollen tube gene products that respond to th

273 er cells with regard to androgen dependence, defining the character or minor subpopulations of androg

274 Beyond defining the functions of CTCF in chromosome folding, th

275 Outcome measures defining the impact of globalization on surgical care we

276 nomas are shown to be an excellent model for defining the impact of selected ferrociphenols as new th

277 Defining the kinetics, dynamics, and cellular location o

278 hlight the importance of soil- and leaf-P in defining the photosynthetic capacity of TMFs, with varia

279 Future studies should focus on better defining the role of MAC and facility and organizational

280 ide cells, de novo protein design as well as defining the role of protein misfolding in neurodegenera

281 This difference defines their distinct roles in the regulation of macrop

282 mediators of autoimmune pathology; however, defining their key effector functions in specific autoim

283 allowing to study iron oxide reduction under defined thermodynamic conditions, MER can also be used t

284 Here we define three key epochs in the transcriptome dynamics of

285 Using this high-throughput approach, we defined three sets of chromosomal non-essential genes es

286 s per 20-N bite-force (T20 N, microV), which defined thresholds.

287 cles preceding the midblastula transition, a defined timing program was present that predicted the in

288 ants, but their functions have not been well defined to date.

289 , we demonstrate how trapping energy in well-defined train of polarization domain walls allows undist

290 Several studies have defined transcription-induced nucleosome intermediates u

291 e spontaneously arising Emu-Myc lymphomas to define transgene architecture, somatic mutations, and st

292 We define two Cas13a protein subfamilies that can operate i

293 We defined two major genomic subtypes of primary stage Ta t

294 model predictions probabilistic with clearly defined uncertainties, and they are thus particularly us

295 molecular subtypes of glioblastoma (GBM) are defined using gene expression and mutation profiles, we

296 antly lower among participants with SCT when defined using HbA1c values (29.2% vs 48.6% for prediabet

297 ay readmission rate for all-cause, surgical (defined using International Statistical Classification o

298 Obligate endosymbiosis is operationally defined when loss or removal of the endosymbiont from th

299 However, more research is required to better define whether the Campylobacter detectable in stormwate

300 egs accumulate abruptly in the skin during a defined window of postnatal tissue development.