ライフサイエンスコーパス: definitive

1 ns and criminal behavior was implied but not definitive.

2 cannabidiol continues to increase but is not definitive.

3 The use of definitive abutments (DAs) at time of implant placement

4 ere observed (50% of 668 events required for definitive analysis).

5 a higher number of cases; moreover, all 606 definitive anaphylaxis deaths would be considered as und

6 xis deaths, of which 95% were classified as 'definitive anaphylaxis deaths'.

7 necessary before a result can be considered definitive, and for studies with small sample sizes it i

8 Only prospective studies may yield definitive answers to this question.

9 Although definitive approaches to alloantibody testing are not po

10 METHODS AND DEFINITIVE AR study (Directional Atherectomy Followed by

11 her randomized studies are needed to provide definitive assessment of the neurodevelopmental safety o

12 led clinical trials will potentially provide definitive assessment of whether weight loss can improve

13 ctivation/detoxification by heme proteins, a definitive assignment of I435 is needed.

14 enterobactin obtained in this work provide a definitive assignment of the stereochemistry at the meta

15 of MD at diagnosis, should not be considered definitive at this time.

16 ogical morbidity is high because there is no definitive benefit to gross total resection compared wit

17 ion of drug-eluting stent platforms offer no definitive benefits.

18 In this report, we provide the first definitive biochemical evidence of endogenous heterotetr

19 as been studied extensively, few examples of definitive biological roles for site-specific PARylation

20 skeleton is an important feature not only of definitive, but also of primitive, erythropoiesis in mam

21 the time between combat injury and receiving definitive care.

22 he cross-sectional nature of the data limits definitive causal determination.

23 No definitive causal relationships between pregnancy and OI

24 Thus, a definitive causal role for functioning circadian clocks

25 have been hypothesized, but studies showing definitive causative relationships between infection and

26 od and, in more than 60% of the patients, no definitive cause can be determined.

27 with chronic lymphocytic meningitis, but no definitive cause was identified.

28 ts show a great diversity indicating that no definitive cause, which applies to the majority of cases

29 The results indicated a definitive change in the fecal microbiome of lactose-int

30 Accordingly, leptosperin and lepteridine are definitive chemical markers for authentication of manuka

31 ilure (LRF) rates after sphincter-preserving definitive chemoradiation (CRT) and is typically associa

32 high locoregional failure (LRF) rates after definitive chemoradiation (CRT), associated with anogeni

33 Definitive chemoradiation results in high cure rates but

34 haracterized in 73 HNSCC patients treated by definitive chemoradiotherapy and correlated with surviva

35 ion among clinical laboratories and prevents definitive classification of variants.

36 , Nigeria and second phase which consists of definitive clinical evaluation and follow-up interventio

37 ent evidence to support broad conclusions or definitive clinical practice guidelines.

38 ience discovery, early drug development, and definitive clinical testing in pivotal trials.

39 No definitive comparative studies of the efficacy of 'awake

40 s some uncertainty over what constitutes the definitive complement of palmitoylated proteins even in

41 ported studies and the small effect size, no definitive conclusion can be achieved about the clinical

42 ecycling has been debated extensively, but a definitive conclusion has not been achieved.

43 This lack of a definitive conclusion might have implications in underst

44 here is insufficient evidence to arrive at a definitive conclusion.

45 More research is required to make definitive conclusions about neoadjuvant chemotherapy, o

46 ce; however, more studies are needed to draw definitive conclusions about the efficacy of patient nav

47 omparisons of porous and nonporous implants, definitive conclusions about the impact of implant mater

48 ld be investigated in a phase 3 trial before definitive conclusions can be made about its risks and b

49 n visits and increases in self-efficacy, but definitive conclusions could not be reached.

50 d wide CIs for progression to late AMD limit definitive conclusions from these findings.

51 dant and often controversial results, and no definitive conclusions have been reached regarding the o

52 prepared using both methods is needed before definitive conclusions may be drawn regarding rhTSH vers

53 prospective randomized trials may offer more definitive conclusions regarding comparisons of open and

54 tudy and the small number of eyes evaluated, definitive conclusions regarding this progression cannot

55 studies conducted were underpowered to allow definitive conclusions.

56 size and short duration of the trial prevent definitive conclusions.

57 tention is now focused on: 1) establishing a definitive consensus for a hemodynamic definition, perha

58 Follow-up was at 1 month and 1 year after definitive crown placement.

59 Primary surgical resection vs definitive CRT.

60 associated SCCAC is potentially curable with definitive CRT.

61 eceived a recommendation before testing; the definitive CT recommendation of the physician was in lin

62 No definitive cure is available for OI and to develop novel

63 roved patient survival, but there remains no definitive cure.

64 velopment and progression of IPF, but robust definitive data are few.

65 ifibrotic therapy will improve outcomes, but definitive data are needed.

66 gative breast cancer, because of the lack of definitive data in these populations.

67 However, the lack of definitive data on spillover by microsporidia, in North

68 To our knowledge, there are no definitive data regarding its recurrence risk factors.

69 literature since the 1950s did not yield any definitive data regarding the duration of cysts in the h

70 A phase 3 trial is warranted for more definitive data.

71 N-gamma <0.2 to >0.7 IU/ml) would allow more definitive detection of recent Mtb infection and potenti

72 cified secondary outcome measure was time to definitive deterioration (>/=7 points) in FACT-G total s

73 Median time to definitive deterioration in FACT-G total score was 11.27

74 entation data can be acquired and allows for definitive determination of the disulfide peptide.

75 We included patients who had a definitive diagnosis and clinical symptoms of AADC defic

76 initially by antenatal ultrasound with more definitive diagnosis made by antenatal or postnatal MRI.

77 es in the living brain may contribute to the definitive diagnosis of AD during life.

78 e fungal infections when administered before definitive diagnosis of an invasive fungal infection in

79 h multiple sclerosis (MS) who had received a definitive diagnosis of asymptomatic NTZ-associated PML

80 We included 250 patients with a definitive diagnosis of MG with available serum samples

81 have preeclampsia/HELLP syndrome before the definitive diagnosis of p-aHUS was made.

82 The definitive diagnosis of valve thrombosis is based on a c

83 Rapid and definitive diagnosis of viral respiratory infections is

84 dence-based guidelines are available for the definitive diagnosis or directed treatment of most blast

85 a long diagnostic odyssey before receiving a definitive diagnosis or may receive no diagnosis at all.

86 Currently, definitive diagnosis relies on the demonstration of bial

87 ents at risk for pulmonary hypertension, but definitive diagnosis requires right-heart catheterizatio

88 Definitive diagnosis, including histological classificat

89 herefore require provocation tests to make a definitive diagnosis; these are often expensive and pote

90 Furthermore, there is no single, definitive diagnostic biomarker that is present across t

91 ed on our findings, we propose the following definitive diagnostic criteria for Perry syndrome: the p

92 system leads to several severe diseases, the definitive diagnostic means are lacking.

93 /intracellular transit amplifying (TA) and a definitive differentiated (D) CD31hiVEGFR2hi/extracellul

94 mportantly, human genetic discoveries enable definitive disease diagnosis and can provide opportuniti

95 be matured into >90% CD31(+)/VE-cadherin(+) definitive ECs.

96 al endoderm (AVE), primitive streak (PS) and definitive endoderm (DE) have yet to be defined.

97 gut spheroids, the intermediate step between definitive endoderm and mature organoids.

98 for GATA6 and GATA4 in the formation of both definitive endoderm and pancreatic progenitor cells.

99 e functional copy of GATA6 is sufficient for definitive endoderm development and pancreas formation,

100 olecular machinery that directs formation of definitive endoderm from pluripotent stem cells is not w

101 Previously we reported that definitive endoderm from which liver was derived, expres

102 ibiting glycogen synthase kinase 3 (GSK3) on definitive endoderm production.

103 twork is conserved in maturing primitive and definitive erythroblasts despite their respective intrav

104 Definitive erythroblasts mature and enucleate extravascu

105 e skeleton genes present in similarly staged definitive erythroblasts, suggesting that the compositio

106 Reduced definitive erythroid colony-forming activity was found i

107 y is characterized by distinct primitive and definitive erythroid lineages.

108 hancement of erythroblast enucleation during definitive erythropoiesis.

109 enocarcinoma) from 1998 to 2011 treated with definitive esophagectomy +/- postoperative radiation and

110 her morphological nor molecular data provide definitive evidence [3].

111 However, definitive evidence and the underlying mechanisms are la

112 Until more definitive evidence becomes available, clinicians should

113 progenitor stage was established, providing definitive evidence for SF3B1 mutations targeting lympho

114 We provide definitive evidence for the existence of 'suction pressu

115 the archaeological record, we have provided definitive evidence for the genetic discontinuity betwee

116 in the normal, adult brain has been raised, definitive evidence has been lacking.

117 Together, these results provide definitive evidence linking Hoxa gene expression to prol

118 Kidney biopsy samples can show definitive evidence of CKD, through common changes such

119 nic cartilage damage even though there is no definitive evidence of how this is achieved.

120 d adverse outcomes after angiography without definitive evidence of their efficacy.

121 We did not find definitive evidence that effects of this intervention di

122 There is definitive evidence that RSV-induced bronchiolitis can d

123 This study provides definitive evidence that sustained activation of EGFR in

124 in-Barr virus (EBV) recombinants, we provide definitive evidence that the viral nuclear protein EBNA3

125 However, there is no definitive evidence that this process occurs in mammals.

126 GEF reconstitution reactions, we now provide definitive evidence that TRAPPII is a bona fide GEF for

127 It provides the most definitive evidence to date that smoking during pregnanc

128 However, there is no definitive evidence to show slit diaphragm (SD) to TJ tr

129 The most common diagnoses at the definitive examination were glaucoma and cataract (51% a

130 Among people referred for definitive examination, 153 (43%) people attended their

131 However, there are few definitive examples of phenotypic expression of lethal r

132 osophy and psychology (e.g., William James), definitive experimental evidence supporting this idea is

133 rgy gaps and limited tunability have stymied definitive experimental probes of their non-Abelian natu

134 356 (39.5%) participants were referred for a definitive eye examination and 107 (11.9%) only needed p

135 We identified 17,993 patients who underwent definitive fixation at 216 trauma centers.

136 Adults with severe injury who underwent definitive fixation of a femoral shaft fracture at a lev

137 Early definitive fixation, within 24 hours, is feasible in mos

138 skin prick test and/or specific IgE are not definitive for the diagnosis of food allergy.

139 The earliest definitive fossil evidence for macroscopic animal-grade

140 We also present new approaches that promise definitive functional answers, which are collectively re

141 Thus, our data provide definitive genetic evidence that Sec61 is the host recep

142 Thousands of monogenic diseases have yielded definitive genomic diagnoses and potential gene therapy

143 ants with joint inflammation and no previous definitive gout diagnosis who had MSU analysis of joint

144 ants with joint inflammation and no previous definitive gout diagnosis who had MSU analysis of joint

145 in a DNA binding complex and is required for definitive haematopoiesis to occur.

146 ryonic stem (ES) cells to both primitive and definitive haematopoietic cells.

147 poietic as well as endothelial genes, in the definitive hemangioblasts (DHs).

148 demethylase KDM2B as a critical regulator of definitive hematopoiesis and lineage commitment of murin

149 eletion from E10.5 onward did not compromise definitive hematopoiesis in the liver, and Vegfc deletio

150 e specification of hematopoietic stem cells (definitive hematopoiesis), as shown by decreased express

151 is that specifies primitive myelopoiesis and definitive hematopoiesis, but not primitive erythropoies

152 adtrp1 regulates primitive myelopoiesis and definitive hematopoiesis.

153 specification of primitive myelopoiesis and definitive hematopoiesis.

154 dothelial cell population similarly to their definitive hematopoietic counterparts.

155 d that CDX4 was expressed exclusively within definitive hematopoietic KDR(+)CD235a(-) mesoderm in a W

156 on analyses on WNT-dependent KDR(+)CD235a(-) definitive hematopoietic mesoderm and WNT-independent KD

157 m revealed strong CDX gene expression within definitive hematopoietic mesoderm.

158 mesoderm harboring exclusively primitive or definitive hematopoietic potential to understand the gen

159 ic potential, but conferred fivefold greater definitive hematopoietic potential, similar to that obse

160 xhibited a fivefold decrease in multilineage definitive hematopoietic potential.

161 rovides a mechanistic basis for WNT-mediated definitive hematopoietic specification from hPSCs.

162 nscription factor in the regulation of human definitive hematopoietic specification, and provides a m

163 tial to understand the genetic regulation of definitive hematopoietic specification.

164 te understanding of the mechanism regulating definitive hematopoietic specification.

165 ersible lineage-tracing model, we identify a definitive hematopoietic stem cell (HSC) that supports l

166 Definitive hematopoietic stem cells, capable of multilin

167 uld undergo surgical lung biopsy to secure a definitive histological diagnosis of usual interstitial

168 replicating forms, whereas cats serve as the definitive host for sexual development.

169 Animal and human studies indicate that definitive host helminth infections may confer protectio

170 understanding of how the large population of definitive HSCs emerges in the foetal liver.

171 reaches the size that matches the number of definitive HSCs in the E12.5 foetal liver.

172 turation of immature embryonic precursors of definitive HSCs, termed pre-HSCs.

173 logy and dental development, it possesses no definitive hylobatid synapomorphies.

174 roaches are also presented to help guide the definitive identification of "specialized" ribosomes, an

175 experimental interest, yet markers for their definitive identification remain both scarce and imperfe

176 work, enabling progenitors to adopt a single definitive identity from several initially permitted opt

177 ute layers of chromosome homology, providing definitive information on gene orthology and paralogy ac

178 d toxicities in patients who were undergoing definitive intensity-modulated radiation therapy (IMRT)

179 Melan-A-stained slides showing definitive invasion were double-stained with Sry-related

180 Although our analyses did not uncover a definitive link between host fattening and the gut micro

181 patient asked whether there is any role for definitive local therapy of his primary bladder tumor wi

182 enting, to our knowledge, the earliest known definitive mammalian middle ear.

183 the potential to reduce toxic effects in the definitive management of locally advanced non-small cell

184 To date, definitive mapping of the spatial and temporal distribut

185 expression of uncoupling protein 1 (UCP1), a definitive marker of brown adipocytes, within HO-contain

186 O and IRD were also investigated, although a definitive mechanism could not be identified as the Mich

187 lating mRNA transcription levels, although a definitive mechanism has not been established.

188 refore, no one mechanism is likely to be the definitive mechanism of action.

189 logenetic analysis that broadly incorporates definitive members of the modern lissamphibian orders an

190 roles of brachyury prior to the evolution of definitive mesoderm, we excised the gene using CRISPR/Ca

191 If SC-XRD is to retain its position as the definitive method of MOF structure determination, these

192 on of cultured isolates and is now often the definitive method used in the clinical microbiology labo

193 can be completed in 1 week, but determining definitive methodological choices will typically take up

194 specific immune interventions can elucidate definitive molecular or cellular nodes that are essentia

195 In 21% (21 of 99) of cases, definitive MR imaging results warranted no further follo

196 the initial presenting complaint prior to a definitive neurological diagnosis or more commonly with

197 idence is not sufficiently robust to draw up definitive nurse: patient ratios.

198 pid to use, non-destructive and structurally definitive on the nanoscale are in demand, especially fo

199 from appendectomies, surgery represents the definitive, one-time only treatment with a well-known ri

200 Definitive options include open aneurysmal repair versus

201 Definitive oral treatment was given at 36 h.

202 nctional organization of the rudiment of the definitive organ.

203 ponsible for production of all temporary and definitive organs during embryogenesis.

204 problem with this hypothesis is the lack of definitive paleoshoreline features.

205 his additional CNM-associated gene provide a definitive pathophysiologic link with these disorders, c

206 If the predicted risk threshold for definitive PDA screening was set at 1% over 3 years, onl

207 test the hypothesis that the availability of definitive pediatric hospital care is significantly more

208 across pollutant categories and quantifiably definitive performance assessments are hampered by a lim

209 signaling in murine HSC function by a novel definitive phenotyping of HSCs.

210 with sexual identification, but here too, a definitive picture has yet to emerge.

211 ese agents has been limited by the lack of a definitive predictive biomarker.

212 ng literature make it difficult to establish definitive predictive factors for breast cancer-related

213 In this work, we sought definitive proof that dicarboxylic acids are produced in

214 o hay fever and then asthma, there is yet no definitive proof that the atopic march is the primary ca

215 We aimed to establish definitive proof-of-principle that circulating microRNAs

216 port a morphologic classification scheme for definitive PVN from the Banff Working Group on Polyomavi

217 rally accepted morphologic classification of definitive PVN that groups histologic changes, reflects

218 epresents the largest systematic analysis of definitive PVN undertaken thus far.

219 Long-term outcomes and more definitive quality-of-life studies for both intervention

220 Definitive quantification provides a new standard for la

221 nts with locally advanced NSCLC treated with definitive radiation.

222 omparable efficacy when used with concurrent definitive radiotherapy for patients with stage III unre

223 ions for the addition of systemic therapy to definitive radiotherapy in the treatment of OPSCC, posto

224 however, studies were of poor quality and a definitive randomised trial was needed.

225 A definitive randomized controlled trial is needed to comp

226 er neoadjuvant RCT were randomly assigned to definitive RCT or surgery.

227 dies and significant heterogeneity precludes definitive reassurance about the longer term cardiovascu

228 Additional evidence is necessary to make a definitive recommendation for or against the use of extr

229 hoped that future research will lead to more definitive recommendations in the form of guidelines.

230 factor is crucial for terminal maturation of definitive red blood cells.

231 Definitive removal of the mass was deferred at the time

232 Definitive replication and confirmation of these finding

233 The objective is to provide a concise definitive review of patient and family organizational p

234 However, a definitive role for endothelial ADAM10 in transmigration

235 Mice infection experiments establish a definitive role for PstP in pathogen survival within the

236 ructs in culture for 120 days to demonstrate definitive sarcomeric structure, cell and matrix deforma

237 new-onset diabetes population would undergo definitive screening, which would identify patients with

238 Here, we show that a definitive signature of interlayer coherence in the meta

239 Although no definitive source of infection was determined from this

240 has been the subject of a comprehensive and definitive standard (ASN-0002).

241 laboratory reference methods traceable to a definitive standard.

242 These data do not allow for a definitive statement of the comparative effectiveness or

243 correlates to a qualitative classification: "Definitive," "Strong," "Moderate," "Limited," "No Report

244 Definitive studies could be derived from mice with targe

245 ntified uPAR elevation in asthma; however, a definitive study regarding which clinical features of as

246 rdia grow in size and differentiate into the definitive subcompartments of the AOTU, BU, and EB.

247 Together, these studies provide definitive support for an essential role of SERT antagon

248 harynx, hypopharynx, and larynx treated with definitive surgery and adjuvant radiotherapy (RT) or CRT

249 of the extremities and/or trunk treated with definitive surgery and adjuvant RT between 1998 and 2011

250 ifying preoperative chemotherapy, completing definitive surgery by 12 weeks from diagnosis, and modif

251 have a higher risk of cancer (80%-100%) and definitive surgery can be recommended.

252 p of patients with biochemical failure after definitive surgery or radiation treatment (62% change in

253 s were least likely to experience a delay in definitive surgery, followed by Medicare and Medicaid pa

254 risk ratios (RRs) to model risk of delay in definitive surgery.

255 Surgical delay, defined as definitive surgical excision occurring more than 6 weeks

256 on chemotherapy 163 of 189 (84.0%) underwent definitive surgical treatment in at least 1 kidney by 12

257 ilateral recurrence more than 6 months after definitive surgical treatment were retrospectively ident

258 agnosis of non-high-grade DCIS who underwent definitive surgical treatment.

259 Cretotrichopsenius represent the earliest definitive termitophiles, shedding light on host associa

260 d, with the aim of offering widespread, more definitive therapeutic options for often very difficult

261 l setting of biochemical failure after prior definitive therapy for primary cancer.

262 as a bridge to transplantation (BTT), and as definitive therapy for toxic ingestion or idiopathic liv

263 BCR post definitive therapy is often associated with disease prog

264 es durable tumor control when used either as definitive therapy or as a postoperative adjuvant therap

265 Physicians might consider definitive therapy with cefazolin for these infections.

266 This study compared definitive therapy with cefazolin vs nafcillin or oxacil

267 blood culture positive for MSSA and received definitive therapy with cefazolin, nafcillin, or oxacill

268 3167 patients, 1163 (37%) patients received definitive therapy with cefazolin.

269 CR) post-therapy will potentially complement definitive therapy with either neo- or adjuvant therapy

270 , improved outcomes have been reported after definitive therapy with hematopoietic stem cell transpla

271 patient autonomy, and despite the absence of definitive therapy, many newly diagnosed individuals are

272 (+)) and do not (BCR (-)) have BCR following definitive therapy.

273 nt reigns, often to the point of withholding definitive therapy.

274 infections, beta-lactams are recommended for definitive therapy; however, the comparative effectivene

275 leukemia virus liganding is dispensable for definitive thrombopoiesis, establishing that fundamental

276 ressive chronic kidney disease (CKD) with no definitive treatment available yet.

277 nized to be an important factor in prompting definitive treatment decisions that prevent irreversible

278 Therefore, more definitive treatment for alphaviral encephalomyelitis sh

279 Dacryocystorhinostomy, the definitive treatment for NLDO, has a high success rate (

280 score upgrade during AS but not with risk of definitive treatment in the intermediate term.

281 n, in 14 patients, HSCT was an effective and definitive treatment of DADA2.

282 underwent an orthotopic liver transplant for definitive treatment of homozygous familial hypercholest

283 beta-hemoglobinopathies for several decades, definitive treatment options have lagged behind.

284 association between younger age and risk of definitive treatment or risk of biochemical recurrence a

285 es with largely unknown etiology and without definitive treatment other than lung transplant to prolo

286 ervation, which is defined as the absence of definitive treatment within 1 year of diagnosis.

287 uding overall biopsy-determined progression, definitive treatment, and pathologic and biochemical out

288 ously control viremia remains an obstacle to definitive treatment.

289 ransplantation (HSCT) represents a potential definitive treatment.

290 rcinoma in situ (DCIS) recurrence risk after definitive treatment.

291 itu]); all but 1 required only resection for definitive treatment.

292 aroscopic lavage alone has been suggested as definitive treatment.

293 A definitive trial is needed to assess the efficacy, cost-

294 A definitive trial of fibrate therapy in this patient popu

295 Although a definitive trial testing whether correcting metabolic ac

296 city, and provided guidance to design larger definitive trials testing efficacy of IVC in treating ad

297 f 55 orbits, 5.5%) were correctly judged as "definitive tumor" in MRI.

298 l gadolinium enhancement and judged them as "definitive tumor," "suspicious of tumor," "postsurgical

299 exist at early stages of development in the definitive ventral endoderm forming the foregut.

300 Although full-scale, definitive weight loss adjuvant intervention trials with