ライフサイエンスコーパス: definitive endoderm

1 sential role for Nodal in development of the definitive endoderm.

2 nd gene expression pattern characteristic of definitive endoderm.

3 terning of mesoderm, and localization of the definitive endoderm.

4 he displacement of the primitive endoderm by definitive endoderm.

5 namely the node, notochord and the emerging definitive endoderm.

6 itant with the emergence of epiblast-derived definitive endoderm.

7 ning the embryonic axis and specification of definitive endoderm.

8 ic phenotypes are both due to defects in the definitive endoderm.

9 uch as prechordal plate, node, notochord and definitive endoderm.

10 tion of the AP axis and specification of the definitive endoderm.

11 fects indicating that Hex is required in the definitive endoderm.

12 s not displaced proximally in the absence of definitive endoderm.

13 terior visceral endoderm and in the anterior definitive endoderm.

14 s migrate out laterally to form mesoderm and definitive endoderm across the entire embryonic cylinder

15 a failure to correctly specify the anterior definitive endoderm (ADE) and prechordal plate (PCP) pro

16 a clear role for the hypoblast and anterior definitive endoderm (ADE) in patterning the overlying ec

17 nce of the forebrain, including the anterior definitive endoderm (ADE), anterior mesendoderm (AME) an

18 erm (AVE) and, subsequently, in the anterior definitive endoderm (ADE), anterior neuroectoderm (ANE),

19 thways required for gastrulation are active, definitive endoderm and all classes of mesoderm are spec

20 tions indirectly in the survival of anterior definitive endoderm and in the maintenance of the anteri

21 gut spheroids, the intermediate step between definitive endoderm and mature organoids.

22 gel in promoting hPS cell differentiation to definitive endoderm and mesoderm.

23 for GATA6 and GATA4 in the formation of both definitive endoderm and pancreatic progenitor cells.

24 nvolved in head patterning, such as anterior definitive endoderm and prechordal mesendoderm.

25 al foregut is derived from the most anterior definitive endoderm and that the liver is probably the m

26 ng gastrulation in the anterior visceral and definitive endoderm and the cephalic neural plate.

27 Helobdella embryo prevents the formation of definitive endoderm and the expression of Lox3 RNA and l

28 Prechordal plate, early definitive endoderm, and anterior visceral endoderm appe

29 ctly specify the anterior-posterior axis and definitive endoderm, and are viable and fertile.

30 rt period of time as they contributed to the definitive endoderm, and combining this with in situ hyb

31 ve endoderm lineage and will be displaced by definitive endoderm arising from the primitive streak du

32 marks the floor plate of the neural tube and definitive endoderm, as well as the node and notochord,

33 e both expressed prominently within anterior definitive endoderm at the time when removal of this tis

34 d 5 results in a permanent window denuded of definitive endoderm, beneath prechordal mesoderm and a v

35 induction step allows for more efficient and definitive endoderm cell formation.

36 ed poor formation and abnormal allocation of definitive endoderm cells on embryonic day 7.5.

37 um produced cultures consisting of up to 80% definitive endoderm cells.

38 Migrating cells (mesoderm and definitive endoderm) contain CXCR4 message while embryon

39 K signalling antagonizes the Activin-induced definitive endoderm (DE) differentiation of human embryo

40 al endoderm (AVE), primitive streak (PS) and definitive endoderm (DE) have yet to be defined.

41 First, definitive endoderm (DE) is induced in the presence of h

42 We identify a definitive endoderm (DE) transcriptomic signature that l

43 ted differentiation of iPS and ES cells into definitive endoderm (DE) would allow the derivation of o

44 ssed first in primitive endoderm and then in definitive endoderm derivatives, including glandular sto

45 traembryonic and precardiac mesoderm, and in definitive endoderm derivatives.

46 Definitive endoderm derived from mouse embryonic stem ce

47 anterior visceral endoderm and the anterior definitive endoderm, develop normally in nehe mutants.

48 ional inactivation of Lhx1 disrupts anterior definitive endoderm development and impedes node and mid

49 e functional copy of GATA6 is sufficient for definitive endoderm development and pancreas formation,

50 ed by a marked delay in the expansion of the definitive endoderm during gastrulation.

51 ta4 generates similar amounts of epCam+Dpp4- definitive endoderm enriched for Cxcr4, FoxA2, FoxA3, Dl

52 emonstrate that Hex function is essential in definitive endoderm for normal development of the forebr

53 ly rescues anterior-posterior patterning and definitive endoderm formation and results in adult viabi

54 The process of definitive endoderm formation in differentiating hES cel

55 rior movements associated with the epiblast, definitive endoderm formation, and anterior specificatio

56 type correlates with defects in mesoderm and definitive endoderm formation, as well as abnormal Nodal

57 This involved activin-induced definitive endoderm formation, FGF/Wnt-induced posterior

58 otein (BMP) signaling after specification of definitive endoderm from pluripotent cells results in a

59 olecular machinery that directs formation of definitive endoderm from pluripotent stem cells is not w

60 Previously we reported that definitive endoderm from which liver was derived, expres

61 by directing cells through stages resembling definitive endoderm, gut-tube endoderm, pancreatic endod

62 any regulatory networks involved in defining definitive endoderm have been identified, the mechanisms

63 ells are able to directly differentiate into definitive endoderm, hepatic progenitors, and mature hep

64 piblast stem cells to study specification of definitive endoderm in vitro.

65 (ES) cells to contribute descendants to the definitive endoderm in wild-type host embryos.

66 Similarly, in avians the underlying definitive endoderm induces cardiogenesis in precardiac

67 rectly positioned but development of rostral definitive endoderm is greatly disturbed in Hex(-/-) emb

68 of the later lulu embryo are also disrupted: definitive endoderm is specified but does not form a gut

69 combination of soluble molecules to generate definitive endoderm-like cells that did not pass through

70 e have focused on directing hES cells to the definitive endoderm lineage as this step is a prerequisi

71 development, but are not recruited into the definitive endoderm lineage during gastrulation.

72 thways are required for specification of the definitive endoderm lineage in mammals and identify Smad

73 expression in the epiblast marks the entire definitive endoderm lineage, the anterior mesendoderm, a

74 drive stem cell differentiation towards the definitive endoderm lineage.

75 t Eomes is required for specification of the definitive endoderm lineage.

76 Conversely, they were negative for a definitive endoderm marker (Sox17) and did not generate

77 x1 target genes, including numerous anterior definitive endoderm markers and components of the Wnt si

78 embryos display defects in headfold fusion, definitive endoderm migration and a failure of the later

79 It is expressed in the definitive endoderm, notochord, and neural tube in embry

80 anterior visceral endoderm (AVE) and rostral definitive endoderm of early mouse embryos.

81 Morphometric analysis revealed that the definitive endoderm of mouse wild-type embryos undergoes

82 to the primitive streak, and subsequently to definitive endoderm of the area pellucida.

83 he visceral endoderm of the yolk sac and the definitive endoderm of the embryo.

84 ferentiation of hESC cultures toward neural, definitive endoderm/pancreatic and early cardiac muscle

85 HDE1 marks a definitive endoderm population with high hepatic potenti

86 ne microenvironments codifying hPSCs towards definitive endoderm, precardiac or presomitic mesoderm w

87 ibiting glycogen synthase kinase 3 (GSK3) on definitive endoderm production.

88 fibroblasts as early as 2.5 weeks; and human definitive endoderm progenitors can be differentiated in

89 2-5 weeks; expandable neural stem cells and definitive endoderm progenitors can be obtained from hum

90 etween stages 3a/b and 4, the intraembryonic definitive endoderm receives contributions mainly from t

91 r of anteroposterior axis formation, EMT and definitive endoderm specification in the mouse.

92 Of interest are organs derived from the definitive endoderm, such as the pancreas and liver, and

93 Of great interest are organs derived from definitive endoderm, such as the pancreas.

94 ventral region of mutant embryos within the definitive endoderm, suggesting an important role of thi

95 in the mutants in several tissues including definitive endoderm, suggesting that a deficiency in ves

96 factor, Sox17, is required for formation of definitive endoderm that gives rise to various organs, i

97 Anterior definitive endoderm, the future pharynx and foregut lini

98 required to specify hepatic fate within the definitive endoderm through activation of the FGF recept

99 then displaced away from the epiblast by the definitive endoderm to become associated with the extra-

100 bsequently, Hex is expressed in the earliest definitive endoderm to emerge from the streak and its ex

101 duction and anterior-posterior patterning of definitive endoderm to generate a coherent roadmap for e

102 e relationship between the hypoblast and the definitive endoderm was defined by following labeled ros

103 Sox17 is required for Nepn expression in the definitive endoderm, while RA signaling restricts expres

104 es against human embryonic stem cell-derived definitive endoderm with the goal of identifying cell su