ライフサイエンスコーパス: deformability

1 direct readout (sensing DNA conformation and deformability).

2 blood cell (RBC) mechanical behavior (i.e., deformability).

3 rticles to microgels with a desired size and deformability.

4 ut muscular phenotypes did not alter nuclear deformability.

5 frequent morphologic abnormalities and lower deformability.

6 te the effect of nuclear shape in whole cell deformability.

7 e invasion but does not with respect to cell deformability.

8 , increased osmotic fragility, and decreased deformability.

9 e inner ear fluids, and membranous labyrinth deformability.

10 RBC aggregation and adhesion, and decreased deformability.

11 l to establish normal membrane stability and deformability.

12 s exhibited more swelling due to higher cell deformability.

13 he separation distance, irrespective of cell deformability.

14 single parasite-exported protein on host RBC deformability.

15 lls based on differences in size, shape, and deformability.

16 mal alterations in nuclear shape and nuclear deformability.

17 the shock-induced decrease in red blood cell deformability.

18 n participate in sliding-filament reversible deformability.

19 ciated with significantly decreased cellular deformability.

20 these complications if they alter blood cell deformability.

21 ndex is a marker of decreased red blood cell deformability.

22 event gut injury and preserve red blood cell deformability.

23 s challenging as they often lack mobility or deformability.

24 uced intestinal injury, lung injury, and RBC deformability.

25 ve played an important role in modeling cell deformability.

26 ction took several seconds to regain maximum deformability.

27 cells, or particles based on size, shape, or deformability.

28 onstraints in a network to be related to its deformability.

29 ite, and schizont stage) due to their varied deformability.

30 ne steps show less intrinsic deformation and deformability.

31 ectrostatic forces in the recognition of DNA deformability.

32 denced by normal oxygen binding and cellular deformability.

33 SEB did not significantly affect neutrophil deformability.

34 terogeneous morphology changes and decreased deformability.

35 an fully account for the observed changes in deformability.

36 lamina, the main structure limiting nuclear deformability.

37 l enable us to assess nuclear elasticity and deformability.

38 o have significant protective effects on RBC deformability.

39 to impaired functionality including loss of deformability.

40 the purpose of improving their strength and deformability.

41 ble Open Reading frame) exert changes on GIE deformability.

42 hod can hence be reliably used to assess RBC deformability.

43 ug resistance produces a similar increase in deformability.

44 ttribute related to the functional erythroid deformability.

45 es not always provide a meaningful proxy for deformability.

46 mechanical phenotyping based on single-cell deformability.

47 The sensor relies on differentiating the RBC deformability (a mechanical biomarker) that is highly co

48 ironments and often requires a high cellular deformability, a property limited by the cell nucleus.

49 sed membrane mechanical stability, decreased deformability, abnormal morphology, and spontaneous vesi

50 ktacytometry, was used to assess sickle cell deformability after mixing deoxygenated cells with buffe

51 toxins differ in their effects on neutrophil deformability, aggregation, and adherence.

52 combination of extended shape, rigidity and deformability allows CNTs to be mechanically dispersed i

53 h muscular diseases caused increased nuclear deformability, almost all mutations tested had defects i

54 This nuclear deformability altered in response to actin, myosin, form

55 ted HL-60 cells, which may also impact their deformability; although lamin A is typically down-regula

56 l types (MDA-MB-436 and MCF-7) with distinct deformabilities and metastatic potentials, and (ii) a he

57 sulted in a significant decrease in membrane deformability and a corresponding increase in the value

58 disorders characterized by reduced cellular deformability and abnormal cell morphology.

59 (sRBC) biomechanics, including pathological deformability and adhesion, correlate with clinical seve

60 collapse is intimately linked to the unique deformability and affinity of PLPs for fibrin fibres, as

61 undamental relationship between DNA sequence/deformability and biological function has attracted nume

62 nding more complex systems that include cell deformability and cell-cell interactions.

63 Viscometry confirmed decreases in RBC deformability and demonstrated significant increases in

64 ttention is paid to ways in which mechanical deformability and electronic performance can coexist.

65 itus (T2DM) are associated with reduced cell deformability and elevated blood viscosity, which contri

66 filtration measurements demonstrated reduced deformability and filterability.

67 soft bodies are not only impressive in their deformability and flexibility but can also be potentiall

68 bited significant decreases in both membrane deformability and flickering.

69 could lead to significant alterations to RBC deformability and increase clearance of both infected an

70 thereby gain insight into DNA conformation, deformability and interactions in different sequence and

71 ss-of-function kinase screen for cancer cell deformability and invasive potential in a high-throughpu

72 of multiple-input control and the resulting deformability and maneuverability.

73 maintain red blood cell morphology, membrane deformability and mechanical stability.

74 1R regulates critical membrane properties of deformability and mechanical strength.

75 eparation platform, flexible cells with high deformability and metastatic propensity flowed out, whil

76 ggests that cellular properties such as cell deformability and microvillus elasticity actively modula

77 t of the storage on the erythrocyte membrane deformability and morphology.

78 ds on a physicochemical balance between cell deformability and physical tissue constraints.

79 Rheologic parameters of erythrocyte deformability and plasma viscosity were measured.

80 Such deposition could limit RBC deformability and promote the production of nitric oxide

81 Mature gametocytes exhibit increased deformability and reappear in the peripheral circulation

82 Biomechanical testing confirmed increased deformability and reduced tensile strength of their skin

83 lohexane ring of Ox, leading to this reduced deformability and resultant decrease in HMGB1a's binding

84 Our results suggest that neglecting cell deformability and rolling velocity may significantly ove

85 We then address the effect of cell deformability and rolling velocity on the flow resistanc

86 ng maturation, midstage gametocytes show low deformability and sequester in the bone marrow and splee

87 xperimental sepsis, significant decreases of deformability and shape-recovery time constant (LORCA) b

88 confounding cellular features, such as cell deformability and signaling, allowing us to focus on the

89 Here, we characterized for the first time deformability and size changes in CD34+ cells, and expel

90 Membrane deformability and stability of primitive erythroblasts,

91 Our computational results on the cell deformability and tank-treading frequency are compared w

92 of such swelling was indicative of the cell deformability and the cytoskeleton mechanics.

93 new method for the in situ study of nuclear deformability and the mechanical coupling between the ce

94 which the infected RBCs gradually lose their deformability and their ability to recover their origina

95 sensors that autonomously regulate their own deformability and thereby flow velocity through capillar

96 parum (Pf-RBCs) parasite lose their membrane deformability and they also exhibit enhanced cytoadheren

97 an important role in the regulation of cell deformability and tumor suppression.

98 stacking (resp. propeller twist and protein deformability) and AT-content that increases in magnitud

99 y (size, shape, and composition), mechanics (deformability), and motility (chemotaxis and migration)

100 exhibiting mutual strengthening, compatible deformability, and a linearly dependent relationship bet

101 n, bendability, A-philicity, protein-induced deformability, and B-DNA twist-revealed that they differ

102 p between tumor-initiating capacity and cell deformability, and demonstrate that tumor-initiating cel

103 ration, increased osmotic fragility, reduced deformability, and heterogeneity in osmotic ektacytometr

104 ber of partners, they ensure cell integrity, deformability, and migration.

105 alylation enhances PMN adherence, spreading, deformability, and motility, functions critical to diape

106 y red blood cell aggregation, red blood cell deformability, and plasma viscosity.

107 RBC tissue trapping, deformability, and RBC aggregation and adhesion were stu

108 ications on erythrocyte membrane morphology, deformability, and stability.

109 Nanoparticle properties such as size, shape, deformability, and surface chemistry all play a role in

110 g-stage cultures at 41 degrees C reduced RBC deformability, and this effect correlated strongly with

111 n when alterations in their size, shape, and deformability are detected.

112 g high sensitivity with excellent mechanical deformability arising from the inherent property of the

113 microporous barriers is regulated by nuclear deformability as controlled by lamin-A and -B, and (ii)

114 ransmigration in vitro are determined by TRC deformability, as a result of low Cdc42 and high Sox2.

115 soluble actin, resulting in altered membrane deformability, as determined by alterations in RBC trans

116 Deformability, as determined by comparing passage times

117 RBC deformability assayed at a physiological shear stress de

118 cal properties, including a decrease in cell deformability associated with F-actin assembly and redis

119 ysis of stored blood showed reduction in RBC deformability at 7 days of storage, reflecting a five-fo

120 ic technology capable of probing single-cell deformability at approximately 2,000 cells/s.

121 : (1) for human RBC, significantly decreased deformability at fluid shear stresses < 5 Pa (LORCA) yet

122 Deformability at the system level is enabled using rigid

123 amazing stiffness, toughness, strength, and deformability attributed to the reconfigurable 3D networ

124 Furthermore, histones impair erythrocyte deformability based on reduced passage of erythrocytes t

125 cking energy, propeller twist angle, protein deformability, bendability, and position preference.

126 T/HS decreases lung injury and improves RBC deformability but exerts a limited protective effect on

127 ties, suggesting that not only the increased deformability but reduced friction may be a factor in en

128 We assessed cell deformability by filtration through filters of 5-microm

129 To understand the regulation of nuclear deformability by these active forces, we created differe

130 found that a mathematical description of DNA-deformability, called V(step), could be used to distingu

131 th the solid inclusion, the observed loss of deformability can be predicted quantitatively using the

132 Subtle changes in red blood cell (RBC) deformability, caused by infection or drug treatment, co

133 Moreover, nuclear shape, mechanics, and deformability change with differentiation state and have

134 dielectric properties of the cells and their deformability characteristics that affect HDLF.

135 that the CR1-dependent increase in membrane deformability could be relevant for facilitating the tra

136 Here, we introduce quantitative deformability cytometry (q-DC), a method for rapid, cali

137 s at days 11, 14, 18 and 21, using Real-Time Deformability Cytometry (RT-DC) and Atomic Force Microsc

138 We introduce real-time deformability cytometry (RT-DC) for continuous cell mech

139 Here, using real-time deformability cytometry and flicker spectroscopy to defi

140 Microfluidic deformability cytometry brings the statistical accuracy

141 Performing real-time deformability cytometry experiments on both model sphere

142 A new method, real-time deformability cytometry, probes cell stiffness at high t

143 y profoundly higher deformation in real-time deformability cytometry.

144 idic microcirculation mimetic, and real-time deformability cytometry.

145 ion result in unexpected relationships among deformability, density, and volume.

146 oth time points in the PDL + T/HS group, but deformability did not return to T/SS levels.

147 d its memory, genome integrity, and cellular deformability during migration, our results highlight th

148 isms underlying reduced red blood cell (RBC) deformability during Plasmodium falciparum (Pf) malaria

149 parameters, such as cell size, density, and deformability, during cellular processes have been inves

150 MSC deformability evaluated using filtration through polycar

151 eratin-free cells show about 60% higher cell deformability even for small deformations.

152 During rotation, duct deformability extends the frequency bandwidth and enhanc

153 Despite the critical importance of fibrin deformability for outcomes of bleeding and thrombosis, t

154 Previously, the control of leukocyte deformability has been attributed to microfilaments or m

155 RBCs with reduced surface area and cellular deformability has long been recognized as contributing t

156 hromatin modifications contribute to nuclear deformability has not been defined.

157 ng red blood cells (RBCs) in size, shape and deformability have extended circulation times and altere

158 res of the nucleus including shape, size and deformability impact its function affecting normal cellu

159 s are heterogeneous in terms of adhesion and deformability in flow.

160 profound size effect in enhancing plastic co-deformability in nanoscale metal-ceramic multilayers.

161 rginine and nitric oxide (NO) pathway on RBC deformability in Pf-infected patients and parasite cultu

162 nd for understanding the physical origins of deformability in soft matter.

163 ation methods, and that a switch in cellular deformability in the transition from immature to mature

164 ir strain to failure, and efforts to improve deformability in these materials are usually found to be

165 nvestigate the role of red blood cells (RBC) deformability in type 2 diabetes mellitus (T2DM) without

166 Human red blood cells (RBCs) deformability in vitro was assessed during iron dextran

167 In both cases, nuclear deformability increases with time, scaling as a power la

168 n CIS is related to decreases in RBC and PMN deformability, increases in RBC aggregation, and increas

169 ffected sRBC biomechanics by decreasing sRBC deformability, increasing sRBC occlusion under normoxic

170 measured by digital video microscopy, and a Deformability index (DI) calculated.

171 Despite their deformability, intraarterially delivered MSCs entrap at

172 Our findings suggest that tumor cell deformability is a key factor in controlling extravasati

173 Sequence-dependent helix deformability is an important component of protein/DNA r

174 These observations suggest that neutrophil deformability is decreased in patients with S and SS.

175 The cell deformability is measured by evaluating the transit time

176 We also show that the effect of RESA on deformability is more pronounced at febrile temperature,

177 We conclude that RBC deformability is reduced in sepsis but that micropore bu

178 Moreover, we show that GIE deformability is regulated by protein kinase A (PKA)-med

179 on of TBP on the TATA box is governed by DNA deformability, its C-proximal repeat contacting the more

180 rochemical performance and robust mechanical deformability; its electrochemical characteristics can b

181 attery achieves significant linear and areal deformability, large twistability and bendability.

182 suspension and in a non-contact manner, the deformability levels of breast cancer cells with differe

183 Decreased erythrocyte deformability may also be important in limiting systemic

184 bundle anatomy takes place under which local deformability may be enhanced.

185 We have used cell deformability measurements and an estimate of the force

186 However, in vitro deformability measurements have not been directly linked

187 in mapping, electron microscopy, and dynamic deformability measurements, we investigated the mechanis

188 's passage time is expected to depend on its deformability, measurements from existing approaches are

189 rocyte (red blood cell; RBC) aggregation and deformability, neutrophil (polymorphonuclear neutrophil;

190 he effect of length scales on the plastic co-deformability of a metal and a ceramic.

191 age of the high compliance and large elastic deformability of a soft polymer gel to directly measure

192 Surprisingly, the deformability of ACBP is greater than that observed for

193 more promising approaches for improving the deformability of amorphous metals that usually exhibit m

194 nsistency between macroscopic plasticity and deformability of an amorphous alloy.

195 Deformability of blood cells is known to influence vascu

196 ogenous L-arginine to the cultures increased deformability of both Pf-free and trophozoite-harboring

197 e effect of cellular cholesterol on membrane deformability of bovine aortic endothelial cells.

198 electroporation with flow cytometry to study deformability of cells at the single-cell level with a t

199 The deformability of cells from the light and middle fractio

200 er a constriction, which is dominated by the deformability of cells, and the transit time required fo

201 We found that the deformability of deoxygenated sickle cells did not regai

202 have examined the kinetics of changes in the deformability of deoxygenated sickle red blood cells whe

203 ing of DNA dictates recognition by PurR, and deformability of DNA along the A-B continuum is importan

204 The deformability of double helical DNA is critical for its

205 Such a device is also used to probe the deformability of elastic capsules and viscoelastic biolo

206 niques have been introduced that exploit the deformability of elastomeric materials like polydimethyl

207 20 and waixenicin A block the changes in the deformability of erythrocytes and inhibit merozoite inva

208 Increased aggregation and decreased deformability of erythrocytes are associated with HIV-in

209 EBA-175 mediates substantial changes in the deformability of erythrocytes by binding to glycophorin

210 und that RESA plays a major role in reducing deformability of host cells at the early ring stage of p

211 We apply this technique to compare the deformability of human myeloid and lymphoid leukemia cel

212 We also noted that ethanol can reverse the deformability of impaired RBCs.

213 estration of immature GIEs and that regained deformability of mature gametocytes is associated with t

214 The deformability of MCF-7 breast cancer cells was character

215 ons, particularly thiocyanate, increased the deformability of microgels during drying.

216 Using this approach we rapidly assay the deformability of native populations of leukocytes and ma

217 of long DNA molecules could originate in the deformability of neighboring base-pair steps.

218 .0001; standardised mixed model) between the deformability of nucleated and enucleated cells, while t

219 Deformability of p45NF-E2-deficient RBCs was markedly re

220 There is a growing recognition that the deformability of particles used for drug delivery plays

221 hanisms responsible for the dramatic loss of deformability of Pf-infected RBCs have remained elusive.

222 Deformability of Plasmodium falciparum gametocyte-infect

223 transported to the host spectrin network, on deformability of ring-stage parasite-harboring human RBC

224 -terminal zinc fingers recognize the extreme deformability of SSBs and drive co-operative, stepwise s

225 e was attributed to the increased mechanical deformability of the 1,5-regioisomer as compared to the

226 estressed cable network is used to model the deformability of the adherent cell actin cytoskeleton.

227 Changing the deformability of the cell by perturbing its cytoskeleton

228 The mechanical stability and deformability of the cell nucleus are crucial to many bi

229 molecular availability that accounts for the deformability of the cell surface and the balance of for

230 rocesses depend critically on the mechanical deformability of the cytoplasm.

231 Among density-fractionated cells, the deformability of the densest fraction was poor and didn'

232 of assemblies were largely determined by the deformability of the effective nanoparticles (that is, n

233 is dependent upon both the polarity and the deformability of the electron density within the metal-s

234 oach, we show that stevor expression impacts deformability of the erythrocyte membrane.

235 The reduced deformability of the HGPS nuclear lamina possibly could

236 The remarkable deformability of the human red blood cell (RBC) results

237 We uncover deformability of the ligand capping layer that leads to

238 hermal-mechanical coupling that exploits the deformability of the LM inclusions to create thermally c

239 show that purposefully engineering a larger deformability of the microchannel, by changing the geome

240 Decreasing the overall deformability of the microvilli greatly reduces a simula

241 suggest that during cell transmigration the deformability of the nucleus could be a limiting factor,

242 ese layers with the AFM tip leads to greater deformability of the surface with decreasing applied loa

243 However, deformability of the tertiary structure, as manifested b

244 ovary cells and find significantly increased deformability of the transformed cells.

245 interplay between the temperature-dependent deformability of the vesicles and the DNA-mediated adhes

246 ntrinsic values, and the sequence-dependent "deformability" of a given dimer.

247 or unparasitized erythrocytes with decreased deformability or rosettes is also a key interaction betw

248 tes, it had little impact on either membrane deformability or stability.

249 largely eliminates cellular features such as deformability or topography as its cause.

250 n the rest of the membrane, lipid asymmetry, deformability, or transport properties of the bilayer, i

251 nogen (P = 0.015), and decreased erythrocyte deformability (P < 0.001).

252 together impair NO production and reduce RBC deformability, particularly at febrile temperature.

253 tivity, topological constraints, and vesicle deformability produces a myriad of dynamical states.

254 Transfused RBCs had abnormal deformability profiles, more prominent in the patients w

255 sly shown to mediate an increase in membrane deformability promoted by CR1 ligation.

256 occurring during RBC storage focusing on RBC deformability, RBC-dependent vasoregulatory function, an

257 ocytes and reduced uninfected red blood cell deformability (RCD) compromise microcirculatory flow, le

258 ethanol co-administration using microfluidic deformability screening.

259 itemia as a testing sample, the microfluidic deformability sensor achieved an excellent sensitivity (

260 throughput and label-free microfluidic cell deformability sensor for quantitative parasitemia measur

261 roscopy and flow cytometry, the microfluidic deformability sensor would possibly allow for label-free

262 donor-specific variations in dose dependent deformability shift were revealed below 500 mug/mL iron

263 A/C in human epithelial cells and measured a deformability similar to that of adult hematopoietic ste

264 roscopic properties of DNA in terms of dimer deformability so that polymers which are intrinsically s

265 althy red blood cells (RBCs) have remarkable deformability, squeezing through narrow capillaries as s

266 ontaneous membrane fragmentation and loss of deformability/stability.

267 LPS and LTA also decreased deformability, suggesting that these toxins directly sti

268 roperties, including charge, polarizability, deformability, surface charge mobility, dielectric featu

269 vasive breast cancer cells exhibited greater deformability than weakly-invasive breast cancer cells.

270 s accompanied by an increase in RBC membrane deformability that positively correlates with the number

271 cell assays show reduced ring-stage Pf-RBCs deformability, the parameters influencing their microcir

272 The protein responds to DNA shape and deformability-the stiff, naturally straight double-helic

273 into the streamlined uropod increases T cell deformability, thereby facilitating migration through co

274 hese can be used to learn about neutron star deformability through observations of the moment of iner

275 orary understanding ascribes the loss of RBC deformability to a 10-fold increase in membrane stiffnes

276 g future energy-storage devices with desired deformability together with high performance.

277 Mechanical deformability underpins many of the advantages of organi

278 al microvillous injury by histology, and RBC deformability using ektacytometry.

279 ecorated RBC (n = 6) displayed limited their deformability (vs six controls, p < 0.05) in two-dimensi

280 In vivo RBC deformability was better preserved by blood plus albumin

281 Neutrophil deformability was determined by examining filtration thr

282 Red cell deformability was determined by filtration.

283 Neutrophil deformability was measured as percent neutrophils filter

284 Red blood cell deformability was measured by a laser-assisted ektacytom

285 RBC membrane deformability was measured using 2-dimensional microchan

286 To assess RBC injury, RBC deformability was measured, as the RBC elongation index

287 nt response to ethanol administration on RBC deformability was noted using our biomimetic microfluidi

288 Erythrocyte deformability was observed at various fluid shear stress

289 RBC deformability was reduced during the acute attack (day0)

290 Red cell deformability was significantly decreased in cardiogenic

291 The cell deformability was then compared with that of a trapped p

292 a tool for biological research, we show the deformability we measure is an early biomarker for pluri

293 Based on physical differences of size and deformability, we explore micro-ellipse filters consisti

294 ed roles of spectrin family proteins in cell deformability, we sought to determine the coupled effect

295 T/HS-induced impairments in RBC deformability were significantly reduced at both time po

296 hen exposed to O(2) but only reached maximum deformability when equilibrated with supraphysiological

297 gths, except for propeller twist and protein deformability which are positively correlated.

298 Deformability while remaining viable is an important mec

299 utrophil (polymorphonuclear neutrophil; PMN) deformability, whole-blood viscosity, and platelet-neutr

300 as thick, PMN in EDTA first exhibited active deformability with little or no displacement, then round