ライフサイエンスコーパス: degeneration

1 te with age, and increase with advancing IVD degeneration.

2 regulates PDL homeostasis by preventing its degeneration.

3 ion of membrane polarity asymmetry in axonal degeneration.

4 and matrix composition with both ageing and degeneration.

5 other forms of neurological dysfunction and degeneration.

6 lar disease including AMD and myopic macular degeneration.

7 trial for the treatment of inherited retinal degeneration.

8 hances gamma-secretase activity and neuronal degeneration.

9 sufficient to protect neurons potently from degeneration.

10 and motor dysfunctions arise from cerebellar degeneration.

11 ween pesticide use and self-reported retinal degeneration.

12 n cannot fully account for the effects of LC degeneration.

13 erlying cause of recessive inherited retinal degeneration.

14 on, bringing about terminal cell atrophy and degeneration.

15 drives the pathogenesis of Stargardt macular degeneration.

16 of RPE cells, ultimately leading to retinal degeneration.

17 strating the involvement of IFT43 in retinal degeneration.

18 tcomes for patients with age-related macular degeneration.

19 ith advanced neovascular age-related macular degeneration.

20 ional programs for arbuscule development and degeneration.

21 etic retinopathy and wet age-related macular degeneration.

22 by occipital skull defects and vitreoretinal degeneration.

23 he notochord band has been observed with IVD degeneration.

24 in the likely cause of PD-associated retinal degeneration.

25 retinal ganglion cell soma and axon, but no degeneration.

26 of these markers is influenced by ageing or degeneration.

27 eptors may alleviate synapse loss and axonal degeneration.

28 ce RPE phagocytosis or prevent photoreceptor degeneration.

29 ly beneficial for patients with this retinal degeneration.

30 (NOS2), developed leukostasis and capillary degeneration.

31 enes, consequently preventing secondary cone degeneration.

32 ng strategy for treating intervertebral disc degeneration.

33 gia (HSP), a disease characterized by axonal degeneration.

34 entosa (RP) and atrophic age-related macular degeneration.

35 degeneration (AMD) and 2 with myopic macular degeneration.

36 seases like glaucoma and age-related macular degeneration.

37 toring vision in patients blinded by retinal degeneration.

38 24 in cells of the NP irrespective of age or degeneration.

39 ist as maladaptive features, leading to axon degeneration.

40 e refined graduation strategies of cartilage degeneration.

41 is followed shortly afterward by early-onset degeneration.

42 y about cone survival in age-related macular degeneration.

43 ions between disability progression and RNFL degeneration.

44 ound to cause nonsyndromic inherited retinal degenerations.

45 ), cataract (13.2%), and age-related macular degeneration (10.3%).

46 of the human retinal dystrophy gene Retinal Degeneration 3 (RD3) is a Golgi-associated protein requi

47 lion to 109.6 million]), age-related macular degeneration (8.4 million [0.9 million to 29.5 million])

48 in the PGRN gene causes frontotemporal lobar degeneration accompanied by TDP-43 accumulation, and pat

49 , RPE abnormalities paralleled photoreceptor degeneration, although there were regions with detectabl

50 Age-related macular degeneration (AMD) affects the retinal pigment epitheliu

51 hic atrophy secondary to age-related macular degeneration (AMD) and 2 eyes (5%) had geographic atroph

52 iagnosed with coincident age-related macular degeneration (AMD) and 2 with myopic macular degeneratio

53 Age-related macular degeneration (AMD) and related macular dystrophies (MDs)

54 atients with neovascular age-related macular degeneration (AMD) and to demonstrate its use to model t

55 vascular and neovascular age-related macular degeneration (AMD) and to provide recommendations on the

56 the association between age-related macular degeneration (AMD) and vision-specific functioning (VSF)

57 n the risk of developing age-related macular degeneration (AMD) continued for people born during the

58 d their association with age-related macular degeneration (AMD) have been described.

59 diagnosed with exudative age-related macular degeneration (AMD) in comparison with eyes with nonexuda

60 n diet and prevalence of age-related macular degeneration (AMD) in countries ranging from Southern to

61 Age-related macular degeneration (AMD) is a leading cause of irreversible bl

62 Age-related macular degeneration (AMD) is a major cause of visual impairment

63 Age-related macular degeneration (AMD) is a progressive retinal neurodegener

64 Age-related macular degeneration (AMD) is the leading cause of irreversible

65 Age-related macular degeneration (AMD) is the most common cause of blindness

66 o evaluate the impact of age-related macular degeneration (AMD) on short out-loud and sustained silen

67 zation (NV) in eyes with age-related macular degeneration (AMD) receiving anti-vascular endothelial g

68 tic retinopathy (DR) and age-related macular degeneration (AMD) remains unclear.

69 n (pLoF) variants within age-related macular degeneration (AMD) risk loci and AMD sub-phenotypes.

70 s of lipid fractions and age-related macular degeneration (AMD) risk.

71 patients with a range of age-related macular degeneration (AMD) severity are associated with their pe

72 ) is an advanced form of age-related macular degeneration (AMD) that leads to progressive and irrever

73 atients with neovascular age-related macular degeneration (AMD) treated initially with bevacizumab an

74 profile of patients with age-related macular degeneration (AMD) using mass spectrometry (MS).

75 pithelium (RPE) cells in age-related macular degeneration (AMD) using polarimetry.

76 d care for patients with age-related macular degeneration (AMD) who are being considered for treatmen

77 study participants with age-related macular degeneration (AMD) with bilateral large drusen or noncen

78 enotypic similarities to age-related macular degeneration (AMD), a common and genetically complex dis

79 Age-related macular degeneration (AMD), a leading contributor of vision loss

80 Other diseases, such as age-related macular degeneration (AMD), develop late in life and are conside

81 e of diseases, including age-related macular degeneration (AMD), glaucoma and refractive error.

82 In age-related macular degeneration (AMD), rare variants in the complement syst

83 tients with intermediate age-related macular degeneration (AMD), without other vitreoretinal patholog

84 on increases the risk of age-related macular degeneration (AMD).

85 n eyes with intermediate age-related macular degeneration (AMD).

86 with a high incidence of age-related macular degeneration (AMD).

87 s which are hallmarks of age-related macular degeneration (AMD).

88 bute the pathogenesis of age-related macular degeneration (AMD).

89 mages from patients with Age-related Macular Degeneration (AMD).

90 ndings in the setting of age-related macular degeneration (AMD).

91 patients with exudative age-related macular degeneration (AMD).

92 etinal disorders such as age-related macular degeneration (AMD).

93 rmal and diseased state (age related macular degeneration, AMD) in the retina.

94 r older with neovascular age-related macular degeneration and a baseline best-corrected visual acuity

95 degenerative diseases such as frontotemporal degeneration and Alzheimer disease.

96 us and colon-resident lymphoid follicle, and degeneration and atrophy of brain microvasculature with

97 on of ATP at 150 mum caused little Wallerian degeneration and behavioral tests showed no significant

98 us humor drainage, elevated IOP, optic nerve degeneration and blindness.

99 splastic, shortened long bones and premature degeneration and calcification of intervertebral discs.

100 yloid-beta (Abeta) protein may cause synapse degeneration and cognitive impairment in Alzheimer's dis

101 The terminal stages of neuronal degeneration and death in neurodegenerative diseases rem

102 P1 from SOD1(G93A) mice also accelerates NMJ degeneration and death.

103 erative diseases such as age-related macular degeneration and diabetic retinopathy.

104 ation as a novel driver of congenital muscle degeneration and identifies a potential novel target to

105 etinal diseases, such as age-related macular degeneration and inherited retinal dystrophies, aoong ot

106 a common disease characterized by cartilage degeneration and joint remodeling.

107 ocytes and lymphocytes, resulting in villous degeneration and lipid malabsorption.

108 ny eye diseases, such as age-related macular degeneration and macular telangiectasia.

109 , the model reveals that lower rates of axon degeneration and more rapid remyelination make relapsing

110 r dystrophy (DMD) is characterized by muscle degeneration and progressive weakness.

111 e is needed to limit the progression of disc degeneration and promote disc self-regeneration capaciti

112 most new Y-linked genes is defined by rapid degeneration and pseudogenization.

113 aw critical parallels to mechanisms of nerve degeneration and regeneration in the CNS and in the cont

114 We explored the potential role of tissue degeneration and remodeling during anuran metamorphosis

115 ys an important role in regulating Wallerian degeneration and remyelination after PNS injury.

116 t leads to chronic inflammation, neuroaxonal degeneration and remyelination.

117 The pathological findings suggest axonal degeneration and repair.

118 turn of adult CD-1Cx30(A88V/A88V) mice from degeneration and rescues hearing.

119 clw-IP3R1-dependent cascade that causes axon degeneration and suggest that Bclw-mimetics could provid

120 astrocytes carry an intrinsic propensity to degeneration and to determine if they can induce non-cel

121 spermatid adhesion (i.e., inducing apical ES degeneration) and BTB function (i.e., basal ES and tight

122 -CFH (protective against age-related macular degeneration) and V62-CFH functioned equivalently, match

123 ter, (3) evidence of overlying photoreceptor degeneration, and (4) absence of scrolled RPE or other s

124 (25.8%) had neovascular age-related macular degeneration, and 32 (25.8%) had other causes of fluid.

125 ght reflexes, phenotypic presence of retinal degeneration, and a non-recordable electroretinogram wit

126 acular degeneration (ARMD), choriocapillaris degeneration, and glomerular thrombotic microangiopathy

127 ent cortical atrophy, neuron loss, dendritic degeneration, and memory deficits.

128 ucleus migration defects, cochlear hair cell degeneration, and profound hearing loss.

129 responsible for concomitant muscle and bone degeneration, and that ACVR2B/Fc prevents these derangem

130 ltered mitochondrial function in VCP-related degeneration, and this new insight may inform efforts to

131 erative diseases beyond frontotemporal lobar degeneration are enriched in CTCF-binding sites found in

132 ment epithelium (RPE) of age-related macular degeneration (ARMD) patients and therefore could be an a

133 eovascularization in wet age-related macular degeneration (ARMD), choriocapillaris degeneration, and

134 s pathologies, including age-related macular degeneration, arthritis, and cancer.

135 Our findings indicate apical dendrite degeneration as a novel cellular pathology that distingu

136 f PIP4K ameliorated neuronal dysfunction and degeneration as assessed using motor performance and ret

137 Thus, pericyte degeneration as seen in neurological disorders such as A

138 months showed significantly lower cartilage degeneration, as assessed with MR imaging; rates of prog

139 assessed using motor performance and retinal degeneration assays respectively.

140 lding cells that are less resilient from the degeneration associated with peripheral infection or tra

141 deletions frequently caused dominant retinal degeneration associated with rhodopsin biosynthesis defe

142 c findings in nonsyndromic inherited retinal degenerations associated with CLN3 mutations.

143 targardt disease is a juvenile onset retinal degeneration, associated with elevated levels of lipofus

144 itutively overexpressing MYB1, expression of degeneration-associated genes is increased and subsequen

145 ate prematurely [4], we identified arbuscule degeneration-associated genes, of which 38% are predicte

146 Age-related macular degeneration automated detection was applied to a 2-clas

147 gressive supranuclear palsy and corticobasal degeneration brain slices.

148 Our results indicate that Mkx prevents PDL degeneration by regulating osteogenesis.

149 lmic diseases, including age-related macular degeneration, cataracts, diabetic retinopathy, glaucoma,

150 transmission of sensory information; axonal degeneration causes impaired tactile sensation and persi

151 hy is a blinding form of age-related macular degeneration characterized by retinal pigmented epitheli

152 and human eyes, both normal and with macular degeneration/choroidal neovascularization.

153 syndrome) and posterior (age-related macular degeneration, diabetic retinopathy and glaucoma) segment

154 e-deficient mice, here we show that pericyte degeneration diminishes global and individual capillary

155 d Pearson correlations were used to evaluate degeneration, diurnal changes, repeatability, and age ef

156 lopment, its expression decreases before NMJ degeneration during aging and in SOD1(G93A) mice, a mous

157 Axon degeneration during development is required to sculpt a

158 of clinical and research interest in macular degeneration, for example in estimating visual prognosis

159 -/- mice exhibited progressive photoreceptor degeneration from P20 onwards.

160 mortem tau pathology in frontotemporal lobar degeneration (FTLD) and (2) tauopathy patients have high

161 zheimer's disease (AD), frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau), and r

162 PPA was associated with frontotemporal lobar degeneration (FTLD) with transactive response DNA-bindin

163 ive disorders including frontotemporal lobar degeneration (FTLD).

164 y from the International Age-related Macular Degeneration Genomics Consortium.

165 halmic diseases, such as age-related macular degeneration, glaucoma, and diabetic retinopathy, are id

166 ed shear stiffness with increasing Pfirrmann degeneration grade (nucleus pulposus grade 1, 12.5 kPa +

167 and a high prevalence of age-related macular degeneration (>14% of blindness) as causes in the high-i

168 P and pathological diagnosis of corticobasal degeneration had severe tau pathology in PSP-related bra

169 shows promise for treating inherited retinal degenerations; however, relevant animal models and bioma

170 n eyes with intermediate age-related macular degeneration (iAMD).

171 Intervertebral disc degeneration (IDD) causes chronic back pain and is linke

172 e of autosomal recessive early onset retinal degeneration in a consanguineous pedigree.

173 ndrite development in wildtype mice, and its degeneration in a mouse model of Huntington's disease.

174 Here we investigate the impact of LC degeneration in a mouse model of tauopathy by lesioning

175 Its malformation during development and degeneration in adulthood impairs motor function.

176 he roles of local protein synthesis and axon degeneration in ALS and can serve as a possible target p

177 Treatment of asymptomatic lattice degeneration in an eye in which the fellow eye had a his

178 immunofluorescence and western-blot that rod degeneration in CERKL-/- zebrafish occurred earlier and

179 ed chemotherapy-induced and Wallerian axonal degeneration in culture by preventing axotomy-induced lo

180 sensory neurons in particular are subject to degeneration in diabetes.

181 These effects correlated with degeneration in dorsal root ganglia (DRG) and sciatic ne

182 als with Lewy body disease, and serotonergic degeneration in human ventromedial caudate nucleus from

183 Here we demonstrate that RPE degeneration in human-cell-culture and mouse models is d

184 at disrupt cGMP homeostasis leads to retinal degeneration in humans through mechanisms that are incom

185 ury, ischemia-reperfusion injury, and kidney degeneration in mammals and is also implicated in heat s

186 es profound hearing loss and outer hair cell degeneration in mice.

187 lthough PR1 slows the progression of retinal degeneration in models of RP in vitro, in vivo analyses

188 AD-synthesizing activity, and it delays axon degeneration in primary neuronal cultures.

189 been our inability to observe GCs and their degeneration in the living human eye.

190 rget the nodal axolemma, induce acute axonal degeneration in the presence of complement, and impair m

191 ommon biological pathways that cause retinal degeneration in various forms of RP, and identify new mo

192 rving mitochondria, and peripheral Wallerian degeneration in vivo.

193 odopsin mislocalisation and eventual retinal degeneration in XLRP.Mutations in the Retinitis Pigmento

194 sis (XLRS) is one of the most common macular degenerations in young males, with a worldwide prevalenc

195 s have not been implicated in Wallerian axon degeneration; instead, axon autonomous, intrinsic mechan

196 disease.SIGNIFICANCE STATEMENT Photoreceptor degeneration is a cause of irreversible blindness in a n

197 Axon degeneration is a hallmark of neurodegenerative disease

198 Axon degeneration is an early event and pathological in neuro

199 r example, the tau pathology in corticobasal degeneration is distinct from that of an AD patient.

200 The mechanism of axon degeneration is incompletely understood.

201 Retinal degeneration is prominent in Parkinson's disease (PD), a

202 Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pr

203 Age related macular degeneration is the leading cause of blindness in the de

204 The other, age-related macular degeneration, is the most common form of blindness in th

205 ibutes to vision loss in age-related macular degeneration, is unclear.

206 Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retina

207 disease characterized by progressive axonal degeneration mainly affecting motor neurons.

208 retina is a therapeutic strategy for retinal degeneration management.

209 Age-related macular degeneration may be more than a "macular" condition but

210 runing relies on receptor-mediated extrinsic degeneration mechanisms to determine which axons are mai

211 Prior to the onset of photoreceptor degeneration, Mertk (-/-) mice had less accumulation of

212 In a light-induced degeneration model, tamoxifen prevented onset of photore

213 t zebrafish displayed midbrain and hindbrain degeneration, modeling PCH-like structural defects in vi

214 atients with neovascular age-related macular degeneration (nAMD) during anti-vascular endothelial gro

215 atients with neovascular age-related macular degeneration (nAMD) from the TReat and extEND (TREND) st

216 al course of neovascular age-related macular degeneration (nAMD) is essential in discussing prognosis

217 ve eyes with neovascular age-related macular degeneration (nAMD) tracked by the Fight Retinal Blindne

218 in eyes with neovascular age-related macular degeneration (nAMD) treated with ranibizumab.

219 ibizumab for neovascular age-related macular degeneration (nAMD), diabetic macular oedema (DME) or br

220 atients with neovascular age-related macular degeneration (nAMD).

221 ocus linked by GWASs to frontotemporal lobar degeneration, nominating a causal variant and causal mec

222 therapy for neovascular age-related macular degeneration (nvAMD) to the research investments made in

223 n (RVO), and neovascular-age related macular degeneration (nvAMD).

224 regimen for neovascular age-related macular degeneration (NVAMD).

225 ling pathway.SIGNIFICANCE STATEMENT Neuronal degeneration occurs in disparate circumstances: during d

226 the progressive adult-onset dysfunction and degeneration of a neuronal network that are seen in pati

227 zheimer's disease, which is characterized by degeneration of acetylcholine-producing neurons.

228 ictive factors, and management of structural degeneration of aortic bioprostheses.

229 disability and is often associated with the degeneration of articular cartilage.

230 e-onset motoneuron disease, characterized by degeneration of axon terminals.

231 er Q5:Q1 ratios that ranged from 1.33 (joint degeneration of back/neck) to 1.69 (chronic sinusitis) w

232 ase (AD), and found profound apical dendrite degeneration of Betz cells in both fALS and sALS, as wel

233 theory for PD based on evidence of parallel degeneration of both central nervous system (CNS) and pe

234 re group of disorders leading to progressive degeneration of cerebral white matter.

235 been proposed to contribute to the selective degeneration of corticospinal neurons in amyotrophic lat

236 Here, we show that CIB1 negatively regulates degeneration of dopaminergic neurons in a mouse model of

237 In line with this, RGMa induced selective degeneration of dopaminergic neurons in the substantia n

238 e (PD) is characterized by slow, progressive degeneration of dopaminergic neurons in the substantia n

239 Our results showed selective degeneration of dopaminergic terminals throughout the st

240 RNA, and total protein content), as well as degeneration of exocrine cells, decreased zymogen granul

241 axons, but severe ataxia due to preferential degeneration of large-diameter myelinated axons.

242 The hallmark of CIPN is degeneration of long axons required for transmission of

243 f motor neuron 1 (SMN1) causes the selective degeneration of lower motor neurons and subsequent atrop

244 ses are progressive disorders resulting from degeneration of neuromuscular junctions (NMJs), which fo

245 promise for slowing age- and disease-related degeneration of NMJs.

246 Degeneration of noradrenergic neurons may underlie the d

247 These CERKL-/- animals showed progressive degeneration of photoreceptor outer segments (OSs) and i

248 nitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares other retinal

249 ss, augmented complement activation and slow degeneration of photoreceptors.

250 and abrogates cellular bioenergetics during degeneration of post-mitotic cells of ocular tissue.

251 INTERPRETATION: Degeneration of serotonin neurons is necessary to trigge

252 ytes, pointing to a strategy to combat fatty degeneration of skeletal muscle.

253 croglial networks exacerbated mHTTx1-induced degeneration of striatal medium-sized spiny neurons.

254 ad to biomechanical problems and accelerated degeneration of the adjacent segments.

255 une response, tissue damage, and progressive degeneration of the adult lung.

256 It contributes to the physiological degeneration of the amphibian pronephros and to the deve

257 ring a robust neuroinflammatory reaction and degeneration of the nigral-dopaminergic neuronal system

258 mice display age-related motor deficits and degeneration of the nigrostriatal system.

259 e synergid cell that ultimately leads to the degeneration of the receptive synergid and PT rupture, r

260 dal gammadelta T cells in a model of chronic degeneration of the retinal pigment epithelium (RPE).

261 ula, striatum, and amygdala, indicating that degeneration of these regions is intimately linked to th

262 The degeneration of this tissue induces an immune response r

263 a neurological disease involving dying-back degeneration of upper motor neurons.

264 icroglia are not essentially involved in RGC degeneration or axonal regeneration after acute CNS inju

265 treatment of neovascular age-related macular degeneration or diabetic macular edema.

266 th sets found by GWAS of age-related macular degeneration (P=1.4 x 10(-12)), ulcerative colitis (P<1.

267 onspinal causes of pain, such as facet joint degeneration, pars defect, or presumed scar neuroma.

268 RM1 is the central executioner of the axonal degeneration pathway that culminates in depletion of axo

269 C-derived RPE cells from age-related macular degeneration patients express increased levels of pro-in

270 search for patients with age-related macular degeneration, performed cataract surgery, and at least 1

271 f-function allele mimic the isolated retinal degeneration phenotype.

272 th a linear molecular pathway for the axonal degeneration program.

273 Degeneration, quantified by Pfirrmann grading, improved

274 itis pigmentosa (RP) is an inherited retinal degeneration (RD) that leads to blindness for which no t

275 OX-2/PGE2-mediated neuronal inflammation and degeneration remains largely unclear and presumably depe

276 lization was slowed and delayed in Wallerian degeneration slow (Wld(S)) axons and this phenotype coul

277 These degeneration studies may propel improvements in nerve re

278 The latter feature explains the multisystem degeneration that characterises ALS.

279 tions, including reduced vision with retinal degeneration, the underlying mechanism of which remains

280 iabetic retinopathy, and age-related macular degeneration, threaten the visual health of children and

281 cellular pathology, characterized by nuclear degeneration through nucleophagy-based LaminB1 degradati

282 on to 124.1 million), by age-related macular degeneration to 8.8 million (0.8 million to 32.1 million

283 s, including stroke, AD, age-related macular degeneration, traumatic brain injury, Parkinson's diseas

284 within the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

285 nts in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

286 orphological features of MNU-induced retinal degeneration using scotopic electroretinography (ERG), o

287 tors (anti-VEGF) for wet age-related macular degeneration (wAMD), and to acquire a snapshot of the fr

288 Age-related macular degeneration was attributed as the main cause of vision

289 Photoreceptor outer segment degeneration was evident, with a significant decrease in

290 The central retinal degeneration was similar to that of cblC deficiency.

291 lecular modulators of synaptic stability and degeneration, we have used the Cln3 (-/-) mouse model of

292 al course of PVD, retinal tears, and lattice degeneration were used to quantitate the visual benefits

293 gressive supranuclear palsy and corticobasal degeneration, which are characterized by intracellular a

294 06 knockout mice develop severe motor neuron degeneration, which can be suppressed by transgenic rest

295 chanism and is capable of inducing apical ES degeneration, which leads to germ cell exfoliation from

296 axonal IP3R1 and prevent paclitaxel-induced degeneration, while Bcl2 and BclxL cannot do so.

297 d to an in-depth GWAS of age-related macular degeneration with 33,976 individuals and 9,857,286 varia

298 d increased incidence of intervertebral disc degeneration with a concomitant decrease in expression o

299 nital Zika syndrome showed a central retinal degeneration with severe GCL loss, borderline inner nucl

300 related behavioral abnormalities and retinal degeneration without improving lipofuscin, C1q, and micr