コーパス検索結果 (１語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 r and PC death) are likely to be primary and degenerative.
2 d 5% organic mitral regurgitation [OMR] [62% degenerative]).
3 ents with severe MR of various etiologies (4 degenerative, 4 functional, and 2 mixed) were treated.
4 rvational study including primary repairs of degenerative AAAs in the Netherlands between 2016 and 20
6 ific effects of aging within LCs or reflects degenerative alterations to the wider supporting microen
7 c dysfunction in epilepsy and in an array of degenerative and autoimmune diseases of the central nerv
10 te immune system is activated in a number of degenerative and inflammatory retinal disorders such as
13 ells of the CNS, and invading macrophages in degenerative and regenerative processes after injury are
14 ypes within dystrophic myofibers and uncover degenerative and regenerative transcriptional pathways u
15 lecule p75(NTR) modulator that downregulates degenerative and upregulates trophic receptor-associated
16 diseases, the majority of which are severe, degenerative, and not currently treatable or preventable
17 sease from genetically mediated or acquired (degenerative) aortopathy remains a challenging clinical
18 : Pulmonary arterial hypertension (PAH) is a degenerative arteriopathy that leads to right ventricula
19 potential clinical use for the treatment of degenerative, autoimmune diseases and for organ transpla
21 caused by functional alterations rather than degenerative brain disease or another structural lesion.
23 al populations with intellectual disability, degenerative brain disease, brain injury, psychiatric di
26 a novel mechanistic framework in the axonal degenerative cascade for therapeutic interventions in a
27 bounded by the nuclear membrane, containing degenerative cell organelles and heterolysosomes (type1)
31 l knockout of Ttbk2 in adult mice results in degenerative cerebellar phenotypes that recapitulate asp
32 d promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., w
33 rd injury - the most common form of which is degenerative cervical myelopathy (DCM) - have provided i
39 ortive therapeutic agent to reduce the early degenerative changes and possible hypertrophic remodelin
41 ignificant pain, disability, and progressive degenerative changes in the knee joint that lead to oste
42 in glucose metabolism, which led to chronic degenerative changes in the outer retina of these mice.
43 be a factor in the precocious development of degenerative changes in the temporomandibular joint (TMJ
44 Mankin scores showed significantly greater degenerative changes in the TMJs of 3- and 10-mo-old Ddr
45 fections, and myelokathexis, which describes degenerative changes of mature neutrophils and hyperplas
46 eration as evidenced by urothelial thinning, degenerative changes such as intracellular vacuole forma
47 cales; these scales are insensitive to early degenerative changes that underlie disease progression.
50 ith similar clinical presentation, including degenerative changes, infection, and insufficiency and p
51 Both injected cohorts showed gliosis and degenerative changes, though ERG responses were minimall
53 way could further our understanding of other degenerative choroidopathies, such as geographic atrophy
54 ruits could contribute to reduce the risk of degenerative chronic diseases due to their bioactive pro
55 ial in the postnatal brain, with progressive degenerative ciliary and behavioral phenotypes; and they
57 ogliosis is associated with normal aging and degenerative conditions such as Alzheimer's disease (AD)
58 ted in the cell death that underlies several degenerative conditions(2), and induction of ferroptosis
59 for 250 genetic diseases, many metabolic and degenerative conditions, and forms of cancer that are an
60 a's involvement in early-stage apoptosis and degenerative conditions, tracking the dynamics of mitoch
67 ervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis (ALS)
68 ysregulated RNP granules drive neuromuscular degenerative disease but have not previously been linked
69 ystrophy (DMD) is an X-linked, lethal muscle degenerative disease caused by loss of dystrophin protei
70 muscular dystrophy (DMD) is a lethal, muscle degenerative disease causing premature death of affected
72 e sclerosis (MS), a chronic inflammatory and degenerative disease of the CNS, and in its mouse model,
73 00), genetically complex and multifactorial, degenerative disease of the cornea whose pathogenesis an
74 dibular joint (TMJ) osteoarthritis (OA) is a degenerative disease of the joint that can produce persi
75 eber hereditary optic neuropathy (LHON) is a degenerative disease of the optic nerve associated with
78 bjects with RPE65 mutation-associated IRD, a degenerative disease that progresses to complete blindne
79 city occurs during progressive photoreceptor degenerative disease to help maintain normal visual beha
80 itis pigmentosa (RP) is an inherited retinal degenerative disease with severe vision impairment leadi
81 cated independently in lifespan, ageing, and degenerative disease(6,12-14)-are thus mechanistically c
83 acic aortic aneurysms have been labeled as a degenerative disease, characterized by alterations in ex
84 mains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP
86 ularly in brain, is thought to contribute to degenerative disease, post-developmental interventions t
100 for being repurposed to treat photoreceptor degenerative disease.SIGNIFICANCE STATEMENT Photorecepto
102 the pathological cell death associated with degenerative diseases (i.e., Alzheimer's, Huntington's,
104 ic cell death process-is involved in various degenerative diseases and represents a targetable suscep
106 ctive drug target for the treatment of neuro-degenerative diseases as well as for brain and spinal co
107 er disparity in the development and types of degenerative diseases as well as highlighting a wide ran
109 show that micro-EI stimulation could affect degenerative diseases based on inflammation, implicating
112 ention and management of several chronic and degenerative diseases including cancer, cardiovascular d
115 for the treatment and prevention of blinding degenerative diseases like retinitis pigmentosa and age-
118 study brain and spinal cord inflammation in degenerative diseases of the CNS such as multiple sclero
119 RP is very similar to that of other retinal degenerative diseases such as age-related macular degene
120 defects observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressiv
122 n ciliopathies, a group of developmental and degenerative diseases that affect almost all organs and
123 ulticellular organisms, a critical driver of degenerative diseases, and can be harnessed for treating
124 its in organelle transport typical of axonal degenerative diseases, and these deficits were worsened
125 ing a central if not primary role in retinal degenerative diseases, and this association should be a
126 therapy for mitral regurgitation (MR) due to degenerative diseases, but information on late outcomes
127 ases, including inherited genetic disorders, degenerative diseases, inflammation, and cancer, has fue
128 ated with aging and with pathologies such as degenerative diseases, metabolic and inflammatory disord
130 explore their therapeutic potential in neuro-degenerative diseases, such as Alzheimer's and Parkinson
131 earning and memory and may be compromised in degenerative diseases, such as Alzheimer's disease.
133 n or morphogenesis leads to blinding retinal degenerative diseases, the majority of which have a gene
134 l of prosthetics for restorative function in degenerative diseases, trauma and amputation; and even a
136 major challenge in the treatment of retinal degenerative diseases, with the transplantation of repla
163 dical history included hypertension, asthma, degenerative disk disease, and migraine, all of which we
164 T Huntington's disease (HD) is a progressive degenerative disorder caused by aberrant trinucleotide e
166 ryngeal Neuropathy (RLN), a highly prevalent degenerative disorder of the RLn in horses that predomin
167 Amyotrophic lateral sclerosis (ALS) is a degenerative disorder that is characterized by loss of m
168 on's disease (HD) is a progressive and fatal degenerative disorder that results in debilitating cogni
169 undus Dystrophy (SFD), an inherited, macular degenerative disorder, caused by mutations in the Tissue
170 he mechanisms by which E2 contributes to TMJ degenerative disorders and the reasons for its targeted
171 1 gene have been identified to cause retinal degenerative disorders generally known as bestrophinopat
172 eponderance of temporomandibular joint (TMJ) degenerative disorders in women and their early onset du
175 to both wild-type p97 and mutants linked to degenerative disorders known as multisystem proteinopath
177 ve stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of
178 -based therapies for the treatment of muscle degenerative disorders should not only regenerate fibers
179 in the development of various age-dependent degenerative disorders such as cancer, neurodegeneration
180 e a heterogeneous group of developmental and degenerative disorders that affect motor unit function.
181 l practice and form a heterogeneous group of degenerative disorders that are classified either as pur
183 is of macular degeneration and other related degenerative disorders, and the normal functions of Vn,
184 ous group of upper and/or lower motor neuron degenerative disorders, in which the particular clinical
188 3 in preventing or delaying the onset of the degenerative effects in a mouse model of osteoarthritis.
190 spinal cord injury (SCI) causes a cascade of degenerative events including cell death, axonal damage,
194 is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and
196 CRISPR)/Cas9 gene editing can knock down pro-degenerative genes in RGCs and provide effective neuropr
198 a proof-of-concept study, a model involving degenerative inflamed human annulus fibrosus (hAF) cells
200 tination, perturb mitochondria, and initiate degenerative inflammatory responses that resemble sporad
203 bular joint (TMJ) disc displacement (DD) and degenerative joint disease (DJD) has never been conclusi
205 teoarthritis (OA) is the most common chronic degenerative joint disease which causes substantial join
213 onic low back pain represent the most common degenerative joint pathologies and are leading causes of
216 sequestered and degraded by mitophagy during degenerative loss of post-mitotic cells of ocular tissue
218 o systematically investigate homeostatic and degenerative mechanisms associated with the TMJ disc.
219 lity of the C9-500 animals for understanding degenerative mechanisms, we validated and established tw
221 ried and 5,475 patients were identified with degenerative mitral disease who underwent mitral valve o
222 nsider atrial fibrillation (AF) complicating degenerative mitral regurgitation (DMR) a debated indica
224 r study, 30 consecutive patients with severe degenerative mitral regurgitation (MR) were treated with
227 outcome after MV repair and replacement for degenerative mitral regurgitation with a flail leaflet.
228 as associated with increased repair rates of degenerative mitral valve disease (adjusted odds ratio [
229 years, 47% women) consecutive patients with degenerative mitral valve disease, in whom LAVI was pros
230 ated the influence of surgeon case volume on degenerative mitral valve repair rates and outcomes.
231 with total annual mitral volumes of >50 and degenerative mitral valve repair rates of >70%, compared
232 els to distinguish the temporal sequences of degenerative molecular processes from other variability
233 c lateral sclerosis (ALS) is a heterogeneous degenerative motor neuron disease linked to numerous gen
234 stment for confounders, job strain predicted degenerative MSDs among women after 4 and 11 years of fo
235 g aging breaks muscle homeostasis and causes degenerative muscle disease by irreversibly dampening sa
237 is thought to arise from the accumulation of degenerative mutations during the sustained co-evolution
239 dismutase 1 (SOD1) is associated with canine degenerative myelopathy: the only naturally occurring la
241 lation results in features characteristic of degenerative neuro-axonal dystrophy, including abnormall
242 -length effect on expression can be found in degenerative neurological illnesses, such as Alzheimer's
244 e those with symptomatic, severe functional, degenerative, or mixed mitral regurgitation deemed at hi
247 for the field since it identifies a defined degenerative pathway involved in axonal degeneration in
248 protected neurons by suppressing both known degenerative pathways and a new pathway involving unliga
249 mutant HTT activates DNA damage-response pro-degenerative pathways and impairs transcription, trigger
250 elated phenotypes and suggests APOE4-related degenerative pathways contributing to AD pathogenesis.
251 ever, whether functional specialization is a degenerative phenomenon unique to sex chromosomes, or if
252 physiologic and inevitable, skin aging is a degenerative phenomenon whereby both intrinsic and envir
253 then demonstrate that pHERV-W ENV induces a degenerative phenotype in microglial cells, driving them
254 Short telomere syndromes have a predominant degenerative phenotype marked by organ failure that most
256 ll molecules targeting alphaSyn reverted the degenerative phenotype under both basal and induced stre
260 f another NMD gene UPF2 also ameliorated the degenerative phenotypes in dipeptide repeat-expressing f
261 iral reverse transcriptase activity prevents degenerative phenotypes observed in fly and rat neurons.
262 ional expression of Nmnat after the onset of degenerative phenotypes significantly delays the progres
263 ows significant symptomatic overlap with non-degenerative primary psychiatric disorders including maj
264 with retinal development, in Tvrm4 mice, the degenerative process can be induced after retinal develo
269 mine neuronal vulnerability early during the degenerative process to gain insight into key events und
275 lopment in Wolfram syndrome, with additional degenerative processes in both white and gray matter.
276 hanges in diffusivity that are indicative of degenerative processes in the primary visual pathway com
278 autoimmune disease driving inflammatory and degenerative processes that damage the central nervous s
279 resulting in robust activation of these cell degenerative processes, and a concomitant increase in mu
283 T Retinitis pigmentosa (RP) is an inherited, degenerative retinal disease that leads to blindness for
285 ing and highlighted the potential for curing degenerative retinal diseases from intrinsic cellular so
293 ults support the existence of an interaxonal degenerative signal that promotes catastrophic degenerat
295 e-zipper kinase (DLK) conveys retrograde pro-degenerative signals to neuronal cell bodies via its dow
296 that chronic GENUS shifts neurons to a less degenerative state, improving synaptic function, enhanci
297 thy mammalian retina, macrophages in retinal degenerative states are not solely comprised of microgli
298 , ligamentous injuries, common traumatic and degenerative tendon pathology, abnormalities of transver
299 pairment and/or late neurological disorders, degenerative tissue effects including circulatory and he
300 ronic heart failure, prior endocarditis, and degenerative valve disease; and had higher median age-ad