ライフサイエンスコーパス: degenerative

1 macular hole were identified: tractional and degenerative.

2 rapies promise exciting avenues for treating degenerative age-related diseases.

3 inflammatory bowel disease, as well as neuro-degenerative Alzheimer's and Parkinson's diseases.

4 an established relation between vascular and degenerative Alzheimer's pathology, the mechanistic link

5 metabolic disease, cancer, and neuromuscular degenerative and age-related disorders.

6 c dysfunction in epilepsy and in an array of degenerative and autoimmune diseases of the central nerv

7 ty, mainly because of tracer accumulation in degenerative and inflammatory bone diseases.

8 te immune system is activated in a number of degenerative and inflammatory retinal disorders such as

9 e has the potential to differentiate between degenerative and malignant osseous abnormalities because

10 The role of microglia in degenerative and regenerative processes after damage of

11 ells of the CNS, and invading macrophages in degenerative and regenerative processes after injury are

12 Degenerative and tractional lamellar macular holes may b

13 status and outcome of patients with calcific degenerative aortic stenosis (AS).

14 Vascular function in calcific degenerative AS is conditioned by the upstream valvular

15 Degenerative ataxias are a common form of neurodegenerat

16 Axotomy activates an intrinsic pro-degenerative axon death signaling cascade involving loss

17 tants revealed that SRSF1 is able to bind to degenerative binding motifs, whereas hnRNP H strictly re

18 date for vision restoration in patients with degenerative blinding diseases.

19 tes as vision-restoring drugs in humans with degenerative blindness.

20 Alzheimer's disease (AD) is a degenerative brain disease that destroys memory and othe

21 ches the scale of pathologies of interest in degenerative brain diseases, such as amyloid plaques and

22 countries, from rheumatic heart disease to a degenerative calcific pathogenesis.

23 ingle) for distinguishing between normal and degenerative cartilage (P < .05), with greater areas und

24 ingle) for distinguishing between normal and degenerative cartilage.

25 ustrates the significance of brain-intrinsic degenerative cascades for immune cell recruitment and MS

26 Brain-intrinsic degenerative cascades have been proposed to be an initia

27 Several degenerative causes were considered.

28 In general, older patients with degenerative cervical myelopathy (DCM) are felt to have

29 Reversible addition-fragmentation type degenerative chain transfer contributes to the narrow di

30 Physiological and degenerative changes affecting human standing balance ar

31 These degenerative changes are further aggravated by proinflam

32 and malignant osseous abnormalities because degenerative changes are not choline-avid; however, the

33 ervation may lose its efficacy if widespread degenerative changes develop in the host brain.

34 However, most of the G3YR mice showed degenerative changes in glomerular mesangial cells, whic

35 maintain the integrity of axons and how the degenerative changes in neuromuscular structure that occ

36 ging might be a promising biomarker of early degenerative changes in PD.

37 il was found to reduce the toxic effects and degenerative changes in the liver and thus provides prot

38 in glucose metabolism, which led to chronic degenerative changes in the outer retina of these mice.

39 results demonstrate spontaneous age-related degenerative changes in the retina, RPE, and choroid of

40 be a factor in the precocious development of degenerative changes in the temporomandibular joint (TMJ

41 Mankin scores showed significantly greater degenerative changes in the TMJs of 3- and 10-mo-old Ddr

42 2A-adrenoreceptor intensified aforementioned degenerative changes in UAC rats.

43 nd the distinct sequence of pathological and degenerative changes make this combined approach attract

44 fections, and myelokathexis, which describes degenerative changes of mature neutrophils and hyperplas

45 A higher severity of BLB degenerative changes was associated with a higher degree

46 No DDR2-dependent degenerative changes were seen in knees.

47 Both injected cohorts showed gliosis and degenerative changes, though ERG responses were minimall

48 a vascularis, which generates the EP, showed degenerative changes.

49 Hence, owing to its degenerative character, reoperation is often needed, enc

50 teaching suggests that aortic stenosis is a degenerative condition whereby "wear and tear" leads to

51 is no approved therapeutic for photoreceptor degenerative conditions like RP and atrophic age-related

52 role of microglia in CNS diseases, including degenerative conditions of the retina.

53 n (TTR) amyloidoses are familial or sporadic degenerative conditions that often feature heavy cardiac

54 or 250 genetic diseases, many metabolic and degenerative conditions, and forms of cancer that are an

55 benefit a number of photoreceptor and other degenerative conditions.

56 which include autoimmune, inflammatory, and degenerative conditions.

57 approach that may have efficacy in multiple degenerative conditions.

58 ciated brain changes in AD and other chronic degenerative conditions.

59 development of chronic pain associated with degenerative connective tissue pathologies, such as inte

60 s and cerebellum, which frequently follows a degenerative course.

61 The GRN phenotypes overlap other degenerative dementias and highlight the limits of actua

62 Accurately distinguishing between different degenerative dementias during life is challenging but in

63 Degenerative disc disease often causes severe low-back p

64 be a valid alternative for the treatment of degenerative disc disease that is more logistically conv

65 ervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis (ALS)

66 Abdominal aortic aneurysm (AAA) is a degenerative disease characterized by aortic dilation an

67 In the degenerative disease Duchenne muscular dystrophy, inflam

68 nd allow for more robust modeling of retinal degenerative disease in vitro.

69 Osteoarthritis (OA) is a progressive degenerative disease of articular cartilage and surround

70 e sclerosis (MS), a chronic inflammatory and degenerative disease of the CNS, and in its mouse model,

71 r dystrophy (DMD) is an X-linked progressive degenerative disease resulting from a mutation in the ge

72 ial corneal dystrophy (FECD) is an inherited degenerative disease that affects the internal endotheli

73 Leber congenital amaurosis, a severe retinal degenerative disease that causes blindness during infanc

74 sclerosis (MS) is a common inflammatory and degenerative disease that causes neurological disability

75 Thyroid eye disease (TED) is a degenerative disease that manifests with detrimental tis

76 ithout prior cardiac disease is considered a degenerative disease with no established risk factors fo

77 igmentosa (RP) is an inherited photoreceptor-degenerative disease, and neuronal degeneration in RP is

78 ators of these processes may drive cancer or degenerative disease, but are also potential therapeutic

79 mains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP

80 Transcatheter MV repair was performed for degenerative disease, present in 90.8% of patients.

81 In the subgroup of patients with degenerative disease, the mean repair rate was 67% (n =

82 -i.e., selective cell-loss paradigms akin to degenerative disease-are less well defined.

83 on of the mammalian retina following retinal degenerative disease.

84 ateral sclerosis (ALS), a fatal motor neuron degenerative disease.

85 e therapy has potential for treating retinal degenerative disease.

86 eral sclerosis (ALS) is a fatal motor neuron degenerative disease.

87 for being repurposed to treat photoreceptor degenerative disease.SIGNIFICANCE STATEMENT Photorecepto

88 the pathological cell death associated with degenerative diseases (i.e., Alzheimer's, Huntington's,

89 is implicated in the etiology of a group of degenerative diseases affecting bone and muscle tissue a

90 ion of autophagy has been linked to multiple degenerative diseases and cancer, thus the identificatio

91 ing is the main risk factor for many chronic degenerative diseases and cancer.

92 to the development of chronic autoimmune and degenerative diseases and cancer.

93 Protein misfolding results in devastating degenerative diseases and cancer.

94 ine and myometabolite levels may combat many degenerative diseases and delay aging.

95 ision plays a fundamental role in cancer and degenerative diseases and has been proposed to be mediat

96 p97 has been implicated in the etiology of degenerative diseases and in cancer.

97 potent stem cells and is applied to model MN-degenerative diseases and in proof-of-principle drug-scr

98 tochondrial dysfunction in acute and chronic degenerative diseases and the cellular signaling pathway

99 Congenital retinal degenerative diseases are blinding disorders characteriz

100 Retinal degenerative diseases are major causes of untreatable bl

101 Retinal degenerative diseases are the leading causes of blindnes

102 er disparity in the development and types of degenerative diseases as well as highlighting a wide ran

103 egy for the treatment of ALS and other human degenerative diseases characterized by axonal degenerati

104 associated with inflammatory, metabolic, and degenerative diseases in humans.

105 romote axon regeneration in injury and other degenerative diseases in the adult CNS.

106 Various retinal degenerative diseases including dry and neovascular age-

107 ential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP).

108 l to restore vision to patients with retinal degenerative diseases like retinitis pigmentosa.

109 is are associated with etiologically-diverse degenerative diseases linked to excessive extracellular

110 Wider implications are that degenerative diseases may need to be treated differently

111 Many chronic degenerative diseases result from aggregation of misfold

112 RP is very similar to that of other retinal degenerative diseases such as age-related macular degene

113 ins and have been implicated in motor neuron degenerative diseases such as amyotrophic lateral sclero

114 uncontrolled degradation of collagen seen in degenerative diseases such as arthritis.

115 Recent work in musculoskeletal degenerative diseases such as osteoarthritis have reveal

116 n ciliopathies, a group of developmental and degenerative diseases that affect almost all organs and

117 igen (Ag)-specific tolerance that can target degenerative diseases that destroy tissues and promote e

118 e the leading cause of many inflammatory and degenerative diseases, as well as an important factor un

119 Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections,

120 m connecting certain iDCMs and other chronic degenerative diseases, laying the groundwork for new the

121 on is associated with many acute and chronic degenerative diseases, mitochondrial biogenesis (MB) is

122 earning and memory and may be compromised in degenerative diseases, such as Alzheimer's disease.

123 The retinal degenerative diseases, which together constitute a leadi

124 s associated with numerous acute and chronic degenerative diseases.

125 as a potential therapeutic target in macular degenerative diseases.

126 nnins, which exert a protective role towards degenerative diseases.

127 and implicate the pathway as a modulator of degenerative diseases.

128 , ATase1 and ATase2, for a subset of chronic degenerative diseases.

129 peripheral nervous system tumors, and common degenerative diseases.

130 in acute lung injury as well as fibrotic and degenerative diseases.

131 ay important roles in human inflammatory and degenerative diseases.

132 es for treating blindness from photoreceptor degenerative diseases.

133 esenting new therapeutic promise for retinal degenerative diseases.

134 r repair the damage associated with aging or degenerative diseases.

135 e stress response and may contribute to some degenerative diseases.

136 s cancer, diabetes, autoimmune disorders and degenerative diseases.

137 protein aggregates, a hallmark of aging and degenerative diseases.

138 on, autoimmune, inflammatory, metabolic, and degenerative diseases.

139 function plays a significant role in retinal degenerative diseases.

140 ssociated with decreased risk of chronic and degenerative diseases.

141 may link the pathogeneses of these two cell-degenerative diseases.

142 the ER, is induced in several age-associated degenerative diseases.

143 dical history included hypertension, asthma, degenerative disk disease, and migraine, all of which we

144 w autosomal recessive neurodevelopmental and degenerative disorder in which the cardinal features inc

145 Amyotrophic lateral sclerosis (ALS) is a degenerative disorder that is characterized by loss of m

146 on's disease (HD) is a progressive and fatal degenerative disorder that results in debilitating cogni

147 phy and hypometabolism suggestive of another degenerative disorder, the amnestic amyloid-negative cas

148 romise for disease modeling and treatment of degenerative disorders including muscular dystrophies.

149 to both wild-type p97 and mutants linked to degenerative disorders known as multisystem proteinopath

150 MD's encompass a heterogeneous group of degenerative disorders often characterized by progressiv

151 in the development of various age-dependent degenerative disorders such as cancer, neurodegeneration

152 to repair cell loss from trauma, aging, and degenerative disorders such as Fuchs endothelial corneal

153 l practice and form a heterogeneous group of degenerative disorders that are classified either as pur

154 tic paraplegias are a heterogeneous group of degenerative disorders that are clinically classified as

155 rganelle dynamics underlie a number of human degenerative disorders, and whole exome sequencing (WES)

156 o the pathogenesis of multiple human retinal degenerative disorders, including age-related macular de

157 hotoreceptor cell death in models of retinal degenerative disorders.

158 ations in bestrophin 1 (BEST1) cause macular degenerative disorders.

159 including reducing the risk of many chronic degenerative disorders.

160 lls vulnerable to premature death in retinal degenerative disorders.

161 ctions are implicated in many hereditary and degenerative disorders.

162 These data further support a pro-degenerative effect of accumulating NMN in axons in vivo

163 or the lifespan of the fly and block the pro-degenerative effects of activated dSarm in vivo.

164 cts, including deformed acrosomal formation, degenerative elongating spermatids and irregular head mo

165 spinal cord injury (SCI) causes a cascade of degenerative events including cell death, axonal damage,

166 recognized that pathology of age-associated degenerative eye diseases such as adult macular degenera

167 tal axon degeneration via an anterograde pro-degenerative factor.

168 is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and

169 om four unrelated families manifesting a non-degenerative form of PCH.

170 Among patients with degenerative grade I spondylolisthesis, the addition of

171 Two types of GSG: Viable and Degenerative GSG were defined.

172 Brr2 RNA binding channel result in a form of degenerative human blindness known as retinitis pigmento

173 Multiple sclerosis is a degenerative inflammatory disease of the CNS characteris

174 tination, perturb mitochondria, and initiate degenerative inflammatory responses that resemble sporad

175 th [DBD]) were reviewed and baseline chronic degenerative injury scored using Remuzzi's classificatio

176 level correctly detects the wide functional degenerative involvement of the photoreceptors.

177 bular joint (TMJ) disc displacement (DD) and degenerative joint disease (DJD) has never been conclusi

178 Importantly, we observe no clinical signs of degenerative joint disease apart from mild, or in one ca

179 Osteoarthritis is a common degenerative joint disease for which no disease-modifyin

180 Osteoarthritis is a degenerative joint disease that ranks among the leading

181 the catabolic phenotype may protect against degenerative joint disease.

182 of SnCs as a therapeutic target for treating degenerative joint disease.

183 red common features with both tractional and degenerative lamellar macular holes and were classified

184 yopic subjects, based on the presence of any degenerative lesion secondary to myopia.

185 fusion for patients with symptomatic grade I degenerative lumbar spondylolisthesis with spinal stenos

186 Hence, pro-degenerative MAPK signaling functions upstream of SARM1

187 hould be considered a risk factor for medial degenerative meniscal tear.

188 whether mechanical symptoms are caused by a degenerative meniscus tear and prompt caution in using p

189 er conservative treatment of patients with a degenerative meniscus tear.

190 ried and 5,475 patients were identified with degenerative mitral disease who underwent mitral valve o

191 r study, 30 consecutive patients with severe degenerative mitral regurgitation (MR) were treated with

192 multicenter registry enrolling patients with degenerative mitral regurgitation with a flail leaflet i

193 Among patients with degenerative mitral regurgitation with a flail leaflet r

194 outcome after MV repair and replacement for degenerative mitral regurgitation with a flail leaflet.

195 determinant of the indication for surgery in degenerative mitral regurgitation.

196 icuspid annular dilation who were undergoing degenerative mitral repair, concomitant tricuspid annulo

197 Degenerative mitral stenosis (DMS) is an important cause

198 Degenerative mitral valve (MV) disease is a common cause

199 as associated with increased repair rates of degenerative mitral valve disease (adjusted odds ratio [

200 urgeons to improve outcomes in patients with degenerative mitral valve disease.

201 ecurrent mitral regurgitation (MR) following degenerative mitral valve repair are poorly understood.

202 udy demonstrated that recurrent MR following degenerative mitral valve repair is associated with adve

203 ated the influence of surgeon case volume on degenerative mitral valve repair rates and outcomes.

204 with total annual mitral volumes of >50 and degenerative mitral valve repair rates of >70%, compared

205 Degenerative mitral valve repair rates remain highly var

206 Severe primary (degenerative) mitral regurgitation (MR) is repaired with

207 c lateral sclerosis (ALS) is a heterogeneous degenerative motor neuron disease linked to numerous gen

208 Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease, causing muscle paraly

209 ral sclerosis (ALS) is the most common adult degenerative motor neuron disease.

210 d therapeutic use of neurotrophic factors in degenerative motor neuron diseases such as amyotrophic l

211 Ataxia is a progressive and devastating degenerative movement disorder commonly associated with

212 to Parkinson's disease (PD), the most common degenerative movement disorder.

213 ndergoing primary mitral repair for isolated degenerative MR over 1 decade.

214 In 1,331 patients with degenerative MR, BNP was prospectively measured at diagn

215 In patients with degenerative MR, BNPratio is a powerful, independent, an

216 a large, multicenter cohort of patients with degenerative MR.

217 ion device (Harpoon TSD-5) designed to treat degenerative MR.

218 routine clinical assessment of patients with degenerative MR.

219 stment for confounders, job strain predicted degenerative MSDs among women after 4 and 11 years of fo

220 5% confidence interval (CI): 1.15, 2.18; for degenerative MSDs, RR = 1.59, 95% CI: 1.21, 2.07) and me

221 ack MSDs, RR = 1.50, 95% CI: 1.05, 2.15; for degenerative MSDs, RR = 1.61, 95% CI: 1.16, 2.22) and bo

222 ack MSDs, RR = 1.72, 95% CI: 1.21, 2.43; for degenerative MSDs, RR = 1.68, 95% CI: 1.25, 2.46) among

223 chenne muscular dystrophy (DMD) is a severe, degenerative muscle disease caused by dystrophin mutatio

224 chenne muscular dystrophy (DMD) is a severe, degenerative muscle disease that is commonly studied usi

225 chenne muscular dystrophy (DMD) is a lethal, degenerative muscle disease with no effective treatment.

226 oach to improve skeletal muscle formation in degenerative muscle disorders.

227 -fold transgenic expression) causes a severe degenerative muscle phenotype in wild-type mice.

228 Osteoarthritis (OA) is a common degenerative musculoskeletal disease highly prevalent in

229 fe separately and jointly predicted back and degenerative musculoskeletal diseases (MSDs).

230 Canine degenerative myelopathy (DM) is a naturally occurring ne

231 e muscles of control animals and exacerbated degenerative myopathies in dystrophin-deficient mice.

232 Histopathologic examination revealed a degenerative myopathy that developed after birth and spe

233 del for the subtype of CIPO characterized by degenerative myopathy.

234 t DUX4 + myonuclei, evoke a slow progressive degenerative myopathy.

235 ICD-9-CM) code of "360.21: Progressive High (Degenerative) Myopia." Myopic CNV was defined as HM with

236 nder disease, a progressive and severe human degenerative nervous system disease caused by a primary

237 ophy) that involve mutations within the anti-degenerative network.

238 (AD) and familial Danish dementia (FDD) are degenerative neurological diseases characterized by amyl

239 -length effect on expression can be found in degenerative neurological illnesses, such as Alzheimer's

240 ciency displays a developmental as well as a degenerative ocular phenotype.

241 e those with symptomatic, severe functional, degenerative, or mixed mitral regurgitation deemed at hi

242 H on high-field SWI could identify prodromal degenerative parkinsonism in iRBD.

243 Although the basic mechanism of its degenerative pathogenesis remains poorly understood, a s

244 Bone degenerative pathologies like osteoporosis may be initia

245 potential following surgery due to increased degenerative pathology, comorbidities, reduced physiolog

246 -1, syntaxin-1, or SNAP-25 loss occurs via a degenerative pathway unrelated to the known synapse func

247 Thus, pro-degenerative pathways activated by dSarm signaling or Nm

248 protected neurons by suppressing both known degenerative pathways and a new pathway involving unliga

249 genetically interact to potently enhance the degenerative phenotype of the NPC cerebellum provides st

250 ll molecules targeting alphaSyn reverted the degenerative phenotype under both basal and induced stre

251 sting that the mechanism responsible for the degenerative process in mice expressing the non-glycosyl

252 activity in one model, and as a progressive degenerative process in the other.

253 The degenerative process involves inflammation and a remarka

254 tabolic regulation or whether they drive the degenerative process is unknown.

255 ct the impacts of genetic background and the degenerative process on DAC structure in RD retina.

256 n our understanding of lipid peroxidation, a degenerative process that is believed to play a key role

257 mine neuronal vulnerability early during the degenerative process to gain insight into key events und

258 ciated with the clinical consequences of the degenerative process, but little is known about regional

259 to be tailored to the specific stage in the degenerative process.

260 used to facilitate the understanding of the degenerative process.

261 ut the relative contributions of multisystem degenerative processes across the spectrum of predemente

262 or pathophysiological contributor to chronic degenerative processes in PD; however, the key molecular

263 ular mechanism of how Sestrins can attenuate degenerative processes such as aging and diabetes by act

264 autoimmune disease driving inflammatory and degenerative processes that damage the central nervous s

265 resulting in robust activation of these cell degenerative processes, and a concomitant increase in mu

266 and Bcl-w and initiates the anterograde pro-degenerative program, highlighting the role of the cell

267 ts to a requirement for the cell body in the degenerative program.

268 may both attenuate chronic pain and slow the degenerative progress in vivo.

269 te imbalances in ER function associated with degenerative protein aggregation diseases.

270 o the design of new therapies against aging, degenerative protein conformational diseases, and specif

271 renergic signal in chondrocytes promotes TMJ degenerative remodelling by chondrocyte-mediated pro-cat

272 ibition of alpha2A-adrenoreceptor attenuated degenerative remodelling in the condylar cartilage and s

273 adrenoreceptors in chondrocytes has roles in degenerative remodelling of temporomandibular joint (TMJ

274 onized by AKT signaling, which modulates the degenerative response by limiting activation of downstre

275 gies for reversing cell loss associated with degenerative retinal conditions.

276 T Retinitis pigmentosa (RP) is an inherited, degenerative retinal disease that leads to blindness for

277 asia type 2; MacTel) is a rare neurovascular degenerative retinal disease.

278 re promising strategies for the treatment of degenerative retinal diseases such as age-related macula

279 g visual function in patients suffering from degenerative retinal diseases.

280 ss of photoreceptors is a common endpoint in degenerative retinal diseases.

281 hich has therapeutic effects against certain degenerative retinal diseases.

282 ine holds great promise for the treatment of degenerative retinal disorders.

283 ficant uncertainty about the neuroprotective/degenerative role of these cells due to a lack of techni

284 , rhegmatogenous retinal detachment, typical degenerative senile retinoschisis, peripheral laser coag

285 , meridional fold, retinal hole, and typical degenerative senile retinoschisis.

286 Here, we analyze the degenerative sequelae that culminate in heart failure an

287 ating in preservation of mitochondria in the degenerative setting.

288 hile inhibiting c-Jun kinase (JNK) and other degenerative signalling.

289 ients, 50 to 80 years of age, who had stable degenerative spondylolisthesis (degree of spondylolisthe

290 ed according to the presence of preoperative degenerative spondylolisthesis (in 135 patients) or its

291 in patients with symptomatic lumbar grade I degenerative spondylolisthesis with spinal stenosis is u

292 with lumbar spinal stenosis, with or without degenerative spondylolisthesis, decompression surgery pl

293 have lumbar spinal stenosis, with or without degenerative spondylolisthesis, has not been substantiat

294 is therefore a function of the regenerative/degenerative status of the muscle, overall muscle mass,

295 ignature of these cells at baseline or under degenerative stress.

296 ndidate genes for the childhood onset-neural degenerative syndrome Brown-Vialetto-Van Laere (BVVL).

297 The degenerative tissue environment drives an enhanced pro-a

298 itiators in both the free radical and iodine degenerative transfer controlled radical polymerization

299 n logic processes and impairments to them in degenerative, traumatic, and psychiatric pathologies.

300 The second type, degenerative, was diagnosed in 48 eyes, and its distinct