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1 l control, and its disorder is implicated in degenerative disease.
2 t steric zipper motif in a PrLD can initiate degenerative disease.
3 retinitis pigmentosa, a progressive retinal degenerative disease.
4 ondary deteriorations associated with neural degenerative disease.
5 to enhance regeneration and the treatment of degenerative disease.
6 n the treatment of genetic causes of retinal degenerative disease.
7 o the cause and progression of neuromuscular degenerative disease.
8 ased approaches for the treatment of retinal degenerative disease.
9 .3% (180/187) and was 100% for patients with degenerative disease.
10 of this strategy for a chronic, progressive degenerative disease.
11 contributes to cellular damage in aging and degenerative disease.
12 eral sclerosis (ALS) is a fatal motor neuron degenerative disease.
13 nic stem cell transplant for treating muscle degenerative disease.
14 y should result in near 100% repair rate for degenerative disease.
15 epithelium (RPE) are associated with retinal degenerative disease.
16 ntation is a potential treatment for retinal degenerative disease.
17 on of the mammalian retina following retinal degenerative disease.
18 ateral sclerosis (ALS), a fatal motor neuron degenerative disease.
19 e therapy has potential for treating retinal degenerative disease.
20 and implicate the pathway as a modulator of degenerative diseases.
21 al vision in people blinded by photoreceptor degenerative diseases.
22 arious disorders, including chronic neuronal degenerative diseases.
23 occurs in inherited and age-related retinal degenerative diseases.
24 iving organisms, but also results in chronic degenerative diseases.
25 d fibrils, underlies a large number of human degenerative diseases.
26 s cancer, diabetes, autoimmune disorders and degenerative diseases.
27 tion of sight in patients blinded by retinal degenerative diseases.
28 cause of vision loss in retinal and macular degenerative diseases.
29 e of replacement cells to treat a variety of degenerative diseases.
30 biology and genetics of common metabolic and degenerative diseases.
31 ed in aging and the pathogenesis of numerous degenerative diseases.
32 protein aggregates, a hallmark of aging and degenerative diseases.
33 l new therapeutic agent for treating retinal degenerative diseases.
34 ted with increased susceptibility to several degenerative diseases.
35 eatment options for certain blinding retinal degenerative diseases.
36 neurons, and pathological inclusions in some degenerative diseases.
37 loid formation, appears to cause a number of degenerative diseases.
38 rbonyls such as acrolein participate in many degenerative diseases.
39 l self-destruction in traumatic injuries and degenerative diseases.
40 force for amyloid-related toxicity in common degenerative diseases.
41 thetics offer hope for patients with retinal degenerative diseases.
42 urther drug development for treating retinal degenerative diseases.
43 sis congenita, pulmonary fibrosis, and other degenerative diseases.
44 athogenesis of inflammatory, infectious, and degenerative diseases.
45 may be a novel therapeutic target in retinal degenerative diseases.
46 ly event in adaptations linked to cancer and degenerative diseases.
47 , these changes are similar to those seen in degenerative diseases.
48 on, autoimmune, inflammatory, metabolic, and degenerative diseases.
49 ent of therapeutic tools of inflammatory and degenerative diseases.
50 d gene therapy for treating blinding retinal degenerative diseases.
51 therapies for myofibrillar myopathy or other degenerative diseases.
52 function plays a significant role in retinal degenerative diseases.
53 ach for treating blindness caused by retinal degenerative diseases.
54 r and whole-animal level, autophagy prevents degenerative diseases.
55 ssociated with decreased risk of chronic and degenerative diseases.
56 erapeutic vaccines against cancer or chronic degenerative diseases.
57 eneration could have serious implications on degenerative diseases.
58 ulation in the genome is linked to aging and degenerative diseases.
59 cell death associated with tissue injury and degenerative diseases.
60 ment of rational treatments for debilitating degenerative diseases.
61 thophysiology, which is associated with many degenerative diseases.
62 formation, apoptosis, aging, and a number of degenerative diseases.
63 ausal roles in many types of amyloid-related degenerative diseases.
64 tion of stem cells for clinical treatment of degenerative diseases.
65 (UPP) is associated with several age-related degenerative diseases.
66 e the major causes of malignancy and chronic degenerative diseases.
67 thway contributes to cell loss in many human degenerative diseases.
68 eases including cancer, diabetes, aging, and degenerative diseases.
69 for progenitor cells in the treatment of CNS degenerative diseases.
70 ) are a promising source for cell therapy in degenerative diseases.
71 y under active consideration for a number of degenerative diseases.
72 ng genetically and chemically induced myelin degenerative diseases.
73 the world is increasingly being dominated by degenerative diseases.
74 the ER, is induced in several age-associated degenerative diseases.
75 apeutic tool for the treatment of cancer and degenerative diseases.
76 ar physical properties is a hallmark of many degenerative diseases.
77 for the development of therapies for retinal degenerative diseases.
78 een identified in a variety of human retinal degenerative diseases.
79 t in the pathogenesis of several genetic and degenerative diseases.
80 may link the pathogeneses of these two cell-degenerative diseases.
81 s associated with numerous acute and chronic degenerative diseases.
82 as a potential therapeutic target in macular degenerative diseases.
83 nnins, which exert a protective role towards degenerative diseases.
84 , ATase1 and ATase2, for a subset of chronic degenerative diseases.
85 peripheral nervous system tumors, and common degenerative diseases.
86 in acute lung injury as well as fibrotic and degenerative diseases.
87 ay important roles in human inflammatory and degenerative diseases.
88 es for treating blindness from photoreceptor degenerative diseases.
89 esenting new therapeutic promise for retinal degenerative diseases.
90 r repair the damage associated with aging or degenerative diseases.
91 promising results in various autoimmune and degenerative diseases.
92 ing a range of infectious, inflammatory, and degenerative diseases.
93 nd to be associated with neural and muscular degenerative diseases.
94 for their potential use in different chronic degenerative diseases.
95 s, have been associated with reduced risk of degenerative diseases.
96 e stress response and may contribute to some degenerative diseases.
97 (THRs) can play a role in aging, cancer and degenerative diseases.
98 have a protective effect on the most common degenerative diseases.
99 tenance of outer segments, which are lost in degenerative diseases.
100 n is a pathological hallmark of many chronic degenerative diseases.
101 hly toxic lesions associated with cancer and degenerative diseases.
104 is implicated in the etiology of a group of degenerative diseases affecting bone and muscle tissue a
106 sion body myositis (IBM), the leading muscle degenerative disease afflicting the elderly, is unknown,
109 e pathophysiology of a wide range of chronic degenerative diseases, although inflammation has long be
110 ervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis (ALS)
112 tabolism in the pathogenesis of motor-neuron degenerative disease and identify a potential for therap
116 ion of autophagy has been linked to multiple degenerative diseases and cancer, thus the identificatio
123 ision plays a fundamental role in cancer and degenerative diseases and has been proposed to be mediat
124 athological basis for the most common muscle degenerative diseases and highlight new and encouraging
126 potent stem cells and is applied to model MN-degenerative diseases and in proof-of-principle drug-scr
127 omains escape regulation leading to severely degenerative diseases and represent an important therape
128 tochondrial dysfunction in acute and chronic degenerative diseases and the cellular signaling pathway
129 aggregate trafficking to inclusion bodies in degenerative diseases and the therapeutic benefit of inc
131 igmentosa (RP) is an inherited photoreceptor-degenerative disease, and neuronal degeneration in RP is
132 clerosis (ALS) is a progressive motor neuron degenerative disease, and the inherited form, familial A
141 may be especially useful in treating retinal degenerative diseases arising from rhodopsin misfolding
142 er disparity in the development and types of degenerative diseases as well as highlighting a wide ran
143 e the leading cause of many inflammatory and degenerative diseases, as well as an important factor un
146 ators of these processes may drive cancer or degenerative disease, but are also potential therapeutic
147 Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections,
148 tion plays a central role in various retinal degenerative diseases, but knowledge is limited regardin
149 lthough stem cells hold promise for treating degenerative diseases by 'seeding' injured tissues, the
151 rial dysfunction in the common metabolic and degenerative diseases, cancer, and aging is still debate
153 cal and inflammatory conditions that include degenerative diseases, cancer, and transplant rejection.
155 e muscular dystrophy is a progressive muscle degenerative disease caused by dystrophin mutations.
156 eich ataxia (FRDA) is an autosomal recessive degenerative disease caused by insufficient expression o
157 nal muscular atrophy (SMA) is a motor neuron degenerative disease caused by low levels of the surviva
159 h may be effective for the treatment of many degenerative diseases caused in part by the interaction
161 nt optic atrophy (DOA) is a retinal neuronal degenerative disease characterized by a progressive bila
163 hic lateral sclerosis (ALS) is a devastating degenerative disease characterized by progressive loss o
165 inese (ML) is a dominantly inherited macular degenerative disease characterized by the presence of su
166 egy for the treatment of ALS and other human degenerative diseases characterized by axonal degenerati
167 ly heterogeneous group of upper-motor-neuron degenerative diseases characterized by selective axonal
168 d with many severe disorders, such as neural degenerative diseases, desmin-related myopathy (DRM), an
170 840 patients who had MV repair for MR due to degenerative diseases from 1985 to 2004 were prospective
172 mains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP
173 the pathological cell death associated with degenerative diseases (i.e., Alzheimer's, Huntington's,
177 d mortality and a greater risk of developing degenerative diseases in adult life, understanding the r
181 so abnormal tissue growth such as cancer and degenerative diseases in which apoptotic caspases are at
182 at regulate autophagy or mitophagy can cause degenerative diseases in which deficient quality control
183 models of cancer and against other chronic, degenerative diseases in which inflammation and oxidativ
184 is an adult-onset, progressive, motor neuron degenerative disease, in which the role of inflammation
185 ounteracting the events that lead to certain degenerative diseases, in particular those associated wi
186 he hallmark feature of a group of late-onset degenerative diseases including Alzheimer, Parkinson, an
189 preventing vision loss secondary to retinal degenerative diseases, including age-related macular deg
190 s that are involved in a wide range of human degenerative diseases, including Alzheimer disease.
191 cause of organ failure is enigmatic for many degenerative diseases, including end-stage liver disease
192 ecular mechanisms underlying certain retinal degenerative diseases, including retinitis pigmentosa an
193 the macular region in patients with retinal degenerative diseases, including two patients with cone-
194 myloid peptides associated with a variety of degenerative diseases induce neurotoxicity in their inte
195 have been made to extrapolate to age-related degenerative disease insights from inflammatory processe
199 developing new transplantation therapies for degenerative diseases is limited by inefficient stem cel
201 omers, the most toxic species of amyloids in degenerative diseases, is critically coupled to the inte
202 proteins for the regulation of cell death in degenerative diseases, ischemic diseases and in cancer.
204 m connecting certain iDCMs and other chronic degenerative diseases, laying the groundwork for new the
205 ore efficient therapies for defeating severe degenerative diseases like Alzheimer's is a major goal o
206 therapeutic approach in patients with muscle degenerative diseases like muscular dystrophy is that in
207 ential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP).
209 is are associated with etiologically-diverse degenerative diseases linked to excessive extracellular
210 f these genes are candidates in the study of degenerative diseases, malignancy, infection and inflamm
211 ed and pathogenic RNP granules that arise in degenerative diseases may be important in reducing their
213 on is associated with many acute and chronic degenerative diseases, mitochondrial biogenesis (MB) is
216 inal muscular atrophy, a common motor neuron degenerative disease of severity commensurate with SMN l
219 e sclerosis (MS), a chronic inflammatory and degenerative disease of the CNS, and in its mouse model,
220 ressive periodontitis, a rapidly progressing degenerative disease of the gingival and periodontal lig
223 The most common cause of low back pain is degenerative disease of the intervertebral disc and othe
226 ecurrent observation of TDP-43 aggregates in degenerative diseases of both the brain and muscle where
228 trition affects key risk factors for chronic degenerative diseases of middle and later life, such as
231 a hallmark of inflammatory, infectious, and degenerative diseases of the central nervous system.
234 tinitis pigmentosa is one of the most common degenerative diseases of the eye and is associated with
237 of proteasomal insufficiency across multiple degenerative diseases of the retina, thereby positioning
238 ath of photoreceptor cells caused by retinal degenerative diseases often results in a complete loss o
239 recover histological damage caused by neuro-degenerative disease or traumatic insults to the brain.
240 tive medicine with respect to tissue injury, degenerative diseases or normal functional declines that
241 with protein mutations, as found in many CNS degenerative diseases, or chronic oxidative stress, as f
246 l vascular disease; gene therapy for retinal degenerative disease; regenerative medicine, including o
248 r dystrophy (DMD) is an X-linked progressive degenerative disease resulting from a mutation in the ge
249 aluated in clinical trials for the inherited degenerative disease retinitis pigmentosa (RP) and for d
251 for being repurposed to treat photoreceptor degenerative disease.SIGNIFICANCE STATEMENT Photorecepto
252 ssed, SMN deficiency causes the motor neuron degenerative disease spinal muscular atrophy (SMA).
256 RP is very similar to that of other retinal degenerative diseases such as age-related macular degene
257 ins and have been implicated in motor neuron degenerative diseases such as amyotrophic lateral sclero
259 maR1 ligands may prove beneficial in retinal degenerative diseases such as diabetic retinopathy.
260 elomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibro
262 ther hand, SLRP depletion is correlated with degenerative diseases such as osteoporosis and ectopic b
263 earning and memory and may be compromised in degenerative diseases, such as Alzheimer's disease.
266 ecedes cone loss in many retinal and macular degenerative diseases, suggesting a rod-dependent trophi
270 andibular joint osteoarthritis (TMJ OA) is a degenerative disease that affects both cartilage and sub
271 ial corneal dystrophy (FECD) is an inherited degenerative disease that affects the internal endotheli
272 Leber congenital amaurosis, a severe retinal degenerative disease that causes blindness during infanc
273 sclerosis (MS) is a common inflammatory and degenerative disease that causes neurological disability
274 Temporomandibular joint osteoarthritis is a degenerative disease that is marked by permanent cartila
276 valent nature of osteoarthritis, a cartilage degenerative disease that results in the erosion of join
277 congenital amaurosis, a progressive retinal degenerative disease that severely impairs sight in chil
278 mutations cause retinitis pigmentosa (RP), a degenerative disease that ultimately results in blindnes
279 n ciliopathies, a group of developmental and degenerative diseases that affect almost all organs and
280 late biochemical events in other age-related degenerative diseases that are analogous to changes asso
281 igen (Ag)-specific tolerance that can target degenerative diseases that destroy tissues and promote e
282 e 2 diabetes (T2D) and Alzheimer disease are degenerative diseases that may share common pathophysiol
283 toplasmic inclusion bodies, observed in many degenerative diseases, that are formed from aggregated p
285 g functional vision in patients with retinal degenerative diseases, the eyes of blind human subjects
288 oach to reconstruction of the body following degenerative diseases, trauma or chronic debilitating co
289 g functional vision in patients with retinal degenerative diseases, USC/Second Sight Medical Products
290 sults from vascular insults but can occur in degenerative diseases where it has typically been subsum
291 ncome countries are dominated by patterns of degenerative diseases (whereas the lower- and middle-inc
293 al to cure or alleviate the symptoms of many degenerative diseases while circumventing concerns regar
294 clerosis (ALS) is a devastating motor neuron degenerative disease whose etiology and pathogenesis rem
295 tis pigmentosa is a severe inherited retinal degenerative disease with a frequency of 1 in 100,000 pe
296 ithout prior cardiac disease is considered a degenerative disease with no established risk factors fo
297 s Malattia Leventinese, an inherited macular degenerative disease with strong similarities to age-rel
298 y, a dominant inherited, early onset macular degenerative disease, with choroidal neovascularization
299 cyte-macrophage lineage to cause progressive degenerative diseases without clinical immunodeficiency.
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