ライフサイエンスコーパス: degenerative disease

1 l control, and its disorder is implicated in degenerative disease.

2 t steric zipper motif in a PrLD can initiate degenerative disease.

3 retinitis pigmentosa, a progressive retinal degenerative disease.

4 ondary deteriorations associated with neural degenerative disease.

5 to enhance regeneration and the treatment of degenerative disease.

6 n the treatment of genetic causes of retinal degenerative disease.

7 o the cause and progression of neuromuscular degenerative disease.

8 ased approaches for the treatment of retinal degenerative disease.

9 .3% (180/187) and was 100% for patients with degenerative disease.

10 of this strategy for a chronic, progressive degenerative disease.

11 contributes to cellular damage in aging and degenerative disease.

12 eral sclerosis (ALS) is a fatal motor neuron degenerative disease.

13 nic stem cell transplant for treating muscle degenerative disease.

14 y should result in near 100% repair rate for degenerative disease.

15 epithelium (RPE) are associated with retinal degenerative disease.

16 ntation is a potential treatment for retinal degenerative disease.

17 on of the mammalian retina following retinal degenerative disease.

18 ateral sclerosis (ALS), a fatal motor neuron degenerative disease.

19 e therapy has potential for treating retinal degenerative disease.

20 and implicate the pathway as a modulator of degenerative diseases.

21 al vision in people blinded by photoreceptor degenerative diseases.

22 arious disorders, including chronic neuronal degenerative diseases.

23 occurs in inherited and age-related retinal degenerative diseases.

24 iving organisms, but also results in chronic degenerative diseases.

25 d fibrils, underlies a large number of human degenerative diseases.

26 s cancer, diabetes, autoimmune disorders and degenerative diseases.

27 tion of sight in patients blinded by retinal degenerative diseases.

28 cause of vision loss in retinal and macular degenerative diseases.

29 e of replacement cells to treat a variety of degenerative diseases.

30 biology and genetics of common metabolic and degenerative diseases.

31 ed in aging and the pathogenesis of numerous degenerative diseases.

32 protein aggregates, a hallmark of aging and degenerative diseases.

33 l new therapeutic agent for treating retinal degenerative diseases.

34 ted with increased susceptibility to several degenerative diseases.

35 eatment options for certain blinding retinal degenerative diseases.

36 neurons, and pathological inclusions in some degenerative diseases.

37 loid formation, appears to cause a number of degenerative diseases.

38 rbonyls such as acrolein participate in many degenerative diseases.

39 l self-destruction in traumatic injuries and degenerative diseases.

40 force for amyloid-related toxicity in common degenerative diseases.

41 thetics offer hope for patients with retinal degenerative diseases.

42 urther drug development for treating retinal degenerative diseases.

43 sis congenita, pulmonary fibrosis, and other degenerative diseases.

44 athogenesis of inflammatory, infectious, and degenerative diseases.

45 may be a novel therapeutic target in retinal degenerative diseases.

46 ly event in adaptations linked to cancer and degenerative diseases.

47 , these changes are similar to those seen in degenerative diseases.

48 on, autoimmune, inflammatory, metabolic, and degenerative diseases.

49 ent of therapeutic tools of inflammatory and degenerative diseases.

50 d gene therapy for treating blinding retinal degenerative diseases.

51 therapies for myofibrillar myopathy or other degenerative diseases.

52 function plays a significant role in retinal degenerative diseases.

53 ach for treating blindness caused by retinal degenerative diseases.

54 r and whole-animal level, autophagy prevents degenerative diseases.

55 ssociated with decreased risk of chronic and degenerative diseases.

56 erapeutic vaccines against cancer or chronic degenerative diseases.

57 eneration could have serious implications on degenerative diseases.

58 ulation in the genome is linked to aging and degenerative diseases.

59 cell death associated with tissue injury and degenerative diseases.

60 ment of rational treatments for debilitating degenerative diseases.

61 thophysiology, which is associated with many degenerative diseases.

62 formation, apoptosis, aging, and a number of degenerative diseases.

63 ausal roles in many types of amyloid-related degenerative diseases.

64 tion of stem cells for clinical treatment of degenerative diseases.

65 (UPP) is associated with several age-related degenerative diseases.

66 e the major causes of malignancy and chronic degenerative diseases.

67 thway contributes to cell loss in many human degenerative diseases.

68 eases including cancer, diabetes, aging, and degenerative diseases.

69 for progenitor cells in the treatment of CNS degenerative diseases.

70 ) are a promising source for cell therapy in degenerative diseases.

71 y under active consideration for a number of degenerative diseases.

72 ng genetically and chemically induced myelin degenerative diseases.

73 the world is increasingly being dominated by degenerative diseases.

74 the ER, is induced in several age-associated degenerative diseases.

75 apeutic tool for the treatment of cancer and degenerative diseases.

76 ar physical properties is a hallmark of many degenerative diseases.

77 for the development of therapies for retinal degenerative diseases.

78 een identified in a variety of human retinal degenerative diseases.

79 t in the pathogenesis of several genetic and degenerative diseases.

80 may link the pathogeneses of these two cell-degenerative diseases.

81 s associated with numerous acute and chronic degenerative diseases.

82 as a potential therapeutic target in macular degenerative diseases.

83 nnins, which exert a protective role towards degenerative diseases.

84 , ATase1 and ATase2, for a subset of chronic degenerative diseases.

85 peripheral nervous system tumors, and common degenerative diseases.

86 in acute lung injury as well as fibrotic and degenerative diseases.

87 ay important roles in human inflammatory and degenerative diseases.

88 es for treating blindness from photoreceptor degenerative diseases.

89 esenting new therapeutic promise for retinal degenerative diseases.

90 r repair the damage associated with aging or degenerative diseases.

91 promising results in various autoimmune and degenerative diseases.

92 ing a range of infectious, inflammatory, and degenerative diseases.

93 nd to be associated with neural and muscular degenerative diseases.

94 for their potential use in different chronic degenerative diseases.

95 s, have been associated with reduced risk of degenerative diseases.

96 e stress response and may contribute to some degenerative diseases.

97 (THRs) can play a role in aging, cancer and degenerative diseases.

98 have a protective effect on the most common degenerative diseases.

99 tenance of outer segments, which are lost in degenerative diseases.

100 n is a pathological hallmark of many chronic degenerative diseases.

101 hly toxic lesions associated with cancer and degenerative diseases.

102 during the lifespan as a result of stroke or degenerative diseases [4].

103 ar-reaching consequences in the treatment of degenerative diseases, acute injury, and aging.

104 is implicated in the etiology of a group of degenerative diseases affecting bone and muscle tissue a

105 t, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.

106 sion body myositis (IBM), the leading muscle degenerative disease afflicting the elderly, is unknown,

107 rces that are implicated in the aetiology of degenerative diseases, ageing and cancer.

108 ore tissues or organs destroyed by injuries, degenerative diseases, aging, or cancer.

109 e pathophysiology of a wide range of chronic degenerative diseases, although inflammation has long be

110 ervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis (ALS)

111 In the neuro-degenerative disease amyotrophic lateral sclerosis (ALS)

112 tabolism in the pathogenesis of motor-neuron degenerative disease and identify a potential for therap

113 mise in replacing tissues and organs lost to degenerative disease and injury.

114 e association between these two hallmarks of degenerative diseases and ageing.

115 nd a yet-unexploited therapeutic approach to degenerative diseases and aging.

116 ion of autophagy has been linked to multiple degenerative diseases and cancer, thus the identificatio

117 transduction pathways frequently results in degenerative diseases and cancer.

118 mportant consequences in the pathogenesis of degenerative diseases and cancer.

119 ing is the main risk factor for many chronic degenerative diseases and cancer.

120 to the development of chronic autoimmune and degenerative diseases and cancer.

121 Protein misfolding results in devastating degenerative diseases and cancer.

122 ine and myometabolite levels may combat many degenerative diseases and delay aging.

123 ision plays a fundamental role in cancer and degenerative diseases and has been proposed to be mediat

124 athological basis for the most common muscle degenerative diseases and highlight new and encouraging

125 p97 has been implicated in the etiology of degenerative diseases and in cancer.

126 potent stem cells and is applied to model MN-degenerative diseases and in proof-of-principle drug-scr

127 omains escape regulation leading to severely degenerative diseases and represent an important therape

128 tochondrial dysfunction in acute and chronic degenerative diseases and the cellular signaling pathway

129 aggregate trafficking to inclusion bodies in degenerative diseases and the therapeutic benefit of inc

130 with reduced tissue regeneration, increased degenerative disease, and cancer.

131 igmentosa (RP) is an inherited photoreceptor-degenerative disease, and neuronal degeneration in RP is

132 clerosis (ALS) is a progressive motor neuron degenerative disease, and the inherited form, familial A

133 many human diseases, including hypertrophy, degenerative diseases, and cancer.

134 s in this process have been linked to aging, degenerative diseases, and cancer.

135 Congenital retinal degenerative diseases are blinding disorders characteriz

136 Numerous degenerative diseases are characterized by the aberrant

137 Current therapies to treat muscle degenerative diseases are limited mostly to the ameliora

138 Retinal degenerative diseases are major causes of untreatable bl

139 Retinal degenerative diseases are the leading causes of blindnes

140 -i.e., selective cell-loss paradigms akin to degenerative disease-are less well defined.

141 may be especially useful in treating retinal degenerative diseases arising from rhodopsin misfolding

142 er disparity in the development and types of degenerative diseases as well as highlighting a wide ran

143 e the leading cause of many inflammatory and degenerative diseases, as well as an important factor un

144 A p150(Glued) motor neuron degenerative disease-associated mutation introduced into

145 Most degenerative diseases begin with a gradual loss of speci

146 ators of these processes may drive cancer or degenerative disease, but are also potential therapeutic

147 Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections,

148 tion plays a central role in various retinal degenerative diseases, but knowledge is limited regardin

149 lthough stem cells hold promise for treating degenerative diseases by 'seeding' injured tissues, the

150 Proinflammatory cytokines in degenerative diseases can lead to the loss of normal phy

151 rial dysfunction in the common metabolic and degenerative diseases, cancer, and aging is still debate

152 ial DNA (mtDNA), and have been implicated in degenerative diseases, cancer, and aging.

153 cal and inflammatory conditions that include degenerative diseases, cancer, and transplant rejection.

154 Retinal degenerative diseases cause photoreceptor loss and often

155 e muscular dystrophy is a progressive muscle degenerative disease caused by dystrophin mutations.

156 eich ataxia (FRDA) is an autosomal recessive degenerative disease caused by insufficient expression o

157 nal muscular atrophy (SMA) is a motor neuron degenerative disease caused by low levels of the surviva

158 The risks of cancer and other degenerative diseases caused by reactive oxygen species

159 h may be effective for the treatment of many degenerative diseases caused in part by the interaction

160 Retinal degenerative disease causing loss of photoreceptor cells

161 nt optic atrophy (DOA) is a retinal neuronal degenerative disease characterized by a progressive bila

162 Abdominal aortic aneurysm (AAA) is a degenerative disease characterized by aortic dilation an

163 hic lateral sclerosis (ALS) is a devastating degenerative disease characterized by progressive loss o

164 Light-chain amyloidosis (AL) is a degenerative disease characterized by the extracellular

165 inese (ML) is a dominantly inherited macular degenerative disease characterized by the presence of su

166 egy for the treatment of ALS and other human degenerative diseases characterized by axonal degenerati

167 ly heterogeneous group of upper-motor-neuron degenerative diseases characterized by selective axonal

168 d with many severe disorders, such as neural degenerative diseases, desmin-related myopathy (DRM), an

169 In the degenerative disease Duchenne muscular dystrophy, inflam

170 840 patients who had MV repair for MR due to degenerative diseases from 1985 to 2004 were prospective

171 An early-onset retinal degenerative disease has been identified in Persian cats

172 mains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP

173 the pathological cell death associated with degenerative diseases (i.e., Alzheimer's, Huntington's,

174 produce a slowly progressing skeletal muscle degenerative disease in mice.

175 nd allow for more robust modeling of retinal degenerative disease in vitro.

176 in non-T-cell malignant, proliferative, and degenerative diseases in a geographic cohort.

177 d mortality and a greater risk of developing degenerative diseases in adult life, understanding the r

178 c progenitor cells that can be used to treat degenerative diseases in humans.

179 associated with inflammatory, metabolic, and degenerative diseases in humans.

180 romote axon regeneration in injury and other degenerative diseases in the adult CNS.

181 so abnormal tissue growth such as cancer and degenerative diseases in which apoptotic caspases are at

182 at regulate autophagy or mitophagy can cause degenerative diseases in which deficient quality control

183 models of cancer and against other chronic, degenerative diseases in which inflammation and oxidativ

184 is an adult-onset, progressive, motor neuron degenerative disease, in which the role of inflammation

185 ounteracting the events that lead to certain degenerative diseases, in particular those associated wi

186 he hallmark feature of a group of late-onset degenerative diseases including Alzheimer, Parkinson, an

187 Various retinal degenerative diseases including dry and neovascular age-

188 Autophagy is dysfunctional in many degenerative diseases including myopathies.

189 preventing vision loss secondary to retinal degenerative diseases, including age-related macular deg

190 s that are involved in a wide range of human degenerative diseases, including Alzheimer disease.

191 cause of organ failure is enigmatic for many degenerative diseases, including end-stage liver disease

192 ecular mechanisms underlying certain retinal degenerative diseases, including retinitis pigmentosa an

193 the macular region in patients with retinal degenerative diseases, including two patients with cone-

194 myloid peptides associated with a variety of degenerative diseases induce neurotoxicity in their inte

195 have been made to extrapolate to age-related degenerative disease insights from inflammatory processe

196 bition as a therapeutic strategy for retinal degenerative diseases involving RPE stress.

197 The etiology of pain as the symptom of degenerative disease is complex and appears to be a comb

198 How neurons respond to stress in degenerative disease is of fundamental importance for id

199 developing new transplantation therapies for degenerative diseases is limited by inefficient stem cel

200 A central component of a number of degenerative diseases is the deposition of protein as am

201 omers, the most toxic species of amyloids in degenerative diseases, is critically coupled to the inte

202 proteins for the regulation of cell death in degenerative diseases, ischemic diseases and in cancer.

203 The inherited early-onset macular degenerative disease known as malattia leventinese (ML)

204 m connecting certain iDCMs and other chronic degenerative diseases, laying the groundwork for new the

205 ore efficient therapies for defeating severe degenerative diseases like Alzheimer's is a major goal o

206 therapeutic approach in patients with muscle degenerative diseases like muscular dystrophy is that in

207 ential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP).

208 l to restore vision to patients with retinal degenerative diseases like retinitis pigmentosa.

209 is are associated with etiologically-diverse degenerative diseases linked to excessive extracellular

210 f these genes are candidates in the study of degenerative diseases, malignancy, infection and inflamm

211 ed and pathogenic RNP granules that arise in degenerative diseases may be important in reducing their

212 Wider implications are that degenerative diseases may need to be treated differently

213 on is associated with many acute and chronic degenerative diseases, mitochondrial biogenesis (MB) is

214 In the hereditary degenerative disease myotonic dystrophy type 1 (DM1), tr

215 Osteoarthritis (OA) is a progressive degenerative disease of articular cartilage and surround

216 inal muscular atrophy, a common motor neuron degenerative disease of severity commensurate with SMN l

217 tis (sIBM) is a poorly understood immune and degenerative disease of skeletal muscle.

218 Multiple sclerosis is an inflammatory, degenerative disease of the central nervous system.

219 e sclerosis (MS), a chronic inflammatory and degenerative disease of the CNS, and in its mouse model,

220 ressive periodontitis, a rapidly progressing degenerative disease of the gingival and periodontal lig

221 patient with primary progressive aphasia, a degenerative disease of the human language network.

222 Best disease (BD) is an inherited degenerative disease of the human macula that results in

223 The most common cause of low back pain is degenerative disease of the intervertebral disc and othe

224 ings of rod loss and its link to age-related degenerative disease of the retina.

225 nd opsin, cause retinitis pigmentosa (RP), a degenerative disease of the retina.

226 ecurrent observation of TDP-43 aggregates in degenerative diseases of both the brain and muscle where

227 The presentation of the common degenerative diseases of late life, such as Alzheimer's

228 trition affects key risk factors for chronic degenerative diseases of middle and later life, such as

229 CP, an AAA-ATPase that, when mutated, causes degenerative diseases of muscle, bone and neurons.

230 Degenerative diseases of the autonomic nervous system in

231 a hallmark of inflammatory, infectious, and degenerative diseases of the central nervous system.

232 mise as a useful class of drugs for treating degenerative diseases of the CNS.

233 ties by themselves can be a primary cause of degenerative diseases of the CNS.

234 tinitis pigmentosa is one of the most common degenerative diseases of the eye and is associated with

235 Our findings link degenerative diseases of the kidney and retina, disorder

236 The pathological spectrum of degenerative diseases of the mitral valve (MV) that caus

237 of proteasomal insufficiency across multiple degenerative diseases of the retina, thereby positioning

238 ath of photoreceptor cells caused by retinal degenerative diseases often results in a complete loss o

239 recover histological damage caused by neuro-degenerative disease or traumatic insults to the brain.

240 tive medicine with respect to tissue injury, degenerative diseases or normal functional declines that

241 with protein mutations, as found in many CNS degenerative diseases, or chronic oxidative stress, as f

242 ng intervention for caregivers of those with degenerative diseases (parent study).

243 Transcatheter MV repair was performed for degenerative disease, present in 90.8% of patients.

244 s on nutrient adequacy as well as in chronic degenerative disease prevention.

245 pies for controlling MMP-1 expression during degenerative disease processes.

246 l vascular disease; gene therapy for retinal degenerative disease; regenerative medicine, including o

247 Many chronic degenerative diseases result from aggregation of misfold

248 r dystrophy (DMD) is an X-linked progressive degenerative disease resulting from a mutation in the ge

249 aluated in clinical trials for the inherited degenerative disease retinitis pigmentosa (RP) and for d

250 Many retinal degenerative diseases show an early loss of rod cells fo

251 for being repurposed to treat photoreceptor degenerative disease.SIGNIFICANCE STATEMENT Photorecepto

252 ssed, SMN deficiency causes the motor neuron degenerative disease spinal muscular atrophy (SMA).

253 The human motor neuron degenerative disease spinal muscular atrophy with respir

254 The motor neuron (MN) degenerative disease, spinal muscular atrophy (SMA) is c

255 Reduced levels of SMN cause the motor neuron degenerative disease, spinal muscular atrophy.

256 RP is very similar to that of other retinal degenerative diseases such as age-related macular degene

257 ins and have been implicated in motor neuron degenerative diseases such as amyotrophic lateral sclero

258 uncontrolled degradation of collagen seen in degenerative diseases such as arthritis.

259 maR1 ligands may prove beneficial in retinal degenerative diseases such as diabetic retinopathy.

260 elomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibro

261 Recent work in musculoskeletal degenerative diseases such as osteoarthritis have reveal

262 ther hand, SLRP depletion is correlated with degenerative diseases such as osteoporosis and ectopic b

263 earning and memory and may be compromised in degenerative diseases, such as Alzheimer's disease.

264 Hereditary retinal degenerative diseases, such as retinitis pigmentosa (RP)

265 Retinal degenerative diseases, such as retinitis pigmentosa and

266 ecedes cone loss in many retinal and macular degenerative diseases, suggesting a rod-dependent trophi

267 When photoreceptors die because of degenerative diseases, surviving retinal networks are le

268 of polypeptides most notably associated with degenerative diseases termed amyloidoses.

269 lamin C, cause a variety of tissue-specific degenerative diseases termed laminopathies.

270 andibular joint osteoarthritis (TMJ OA) is a degenerative disease that affects both cartilage and sub

271 ial corneal dystrophy (FECD) is an inherited degenerative disease that affects the internal endotheli

272 Leber congenital amaurosis, a severe retinal degenerative disease that causes blindness during infanc

273 sclerosis (MS) is a common inflammatory and degenerative disease that causes neurological disability

274 Temporomandibular joint osteoarthritis is a degenerative disease that is marked by permanent cartila

275 Thyroid eye disease (TED) is a degenerative disease that manifests with detrimental tis

276 valent nature of osteoarthritis, a cartilage degenerative disease that results in the erosion of join

277 congenital amaurosis, a progressive retinal degenerative disease that severely impairs sight in chil

278 mutations cause retinitis pigmentosa (RP), a degenerative disease that ultimately results in blindnes

279 n ciliopathies, a group of developmental and degenerative diseases that affect almost all organs and

280 late biochemical events in other age-related degenerative diseases that are analogous to changes asso

281 igen (Ag)-specific tolerance that can target degenerative diseases that destroy tissues and promote e

282 e 2 diabetes (T2D) and Alzheimer disease are degenerative diseases that may share common pathophysiol

283 toplasmic inclusion bodies, observed in many degenerative diseases, that are formed from aggregated p

284 In the subgroup of patients with degenerative disease, the mean repair rate was 67% (n =

285 g functional vision in patients with retinal degenerative diseases, the eyes of blind human subjects

286 ated symptom, most often as the harbinger of degenerative disease: the progressive aphasias.

287 L and MAGL inhibitors in pain, inflammation, degenerative diseases, tissue injury, and cancer.

288 oach to reconstruction of the body following degenerative diseases, trauma or chronic debilitating co

289 g functional vision in patients with retinal degenerative diseases, USC/Second Sight Medical Products

290 sults from vascular insults but can occur in degenerative diseases where it has typically been subsum

291 ncome countries are dominated by patterns of degenerative diseases (whereas the lower- and middle-inc

292 The retinal degenerative diseases, which together constitute a leadi

293 al to cure or alleviate the symptoms of many degenerative diseases while circumventing concerns regar

294 clerosis (ALS) is a devastating motor neuron degenerative disease whose etiology and pathogenesis rem

295 tis pigmentosa is a severe inherited retinal degenerative disease with a frequency of 1 in 100,000 pe

296 ithout prior cardiac disease is considered a degenerative disease with no established risk factors fo

297 s Malattia Leventinese, an inherited macular degenerative disease with strong similarities to age-rel

298 y, a dominant inherited, early onset macular degenerative disease, with choroidal neovascularization

299 cyte-macrophage lineage to cause progressive degenerative diseases without clinical immunodeficiency.

300 profile for the treatment of chronic retinal degenerative diseases without systemic exposure.