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1  animal models of retinal injury and retinal degenerative disease.
2  estimate disability of patients with spinal degenerative disease.
3 sistent visual function during photoreceptor degenerative disease.
4 ateral sclerosis (ALS), a fatal motor neuron degenerative disease.
5 e therapy has potential for treating retinal degenerative disease.
6 l control, and its disorder is implicated in degenerative disease.
7 t steric zipper motif in a PrLD can initiate degenerative disease.
8  retinitis pigmentosa, a progressive retinal degenerative disease.
9 ondary deteriorations associated with neural degenerative disease.
10 to enhance regeneration and the treatment of degenerative disease.
11 ishing them from osteoarthritis, a primarily degenerative disease.
12 n the treatment of genetic causes of retinal degenerative disease.
13 o the cause and progression of neuromuscular degenerative disease.
14 rable potential for the treatment of retinal degenerative disease.
15  cancer therapy and its malfunction causes a degenerative disease.
16 ased approaches for the treatment of retinal degenerative disease.
17 .3% (180/187) and was 100% for patients with degenerative disease.
18  of this strategy for a chronic, progressive degenerative disease.
19 odevelopmental component and is not solely a degenerative disease.
20  contributes to cellular damage in aging and degenerative disease.
21 toreceptor cells in a mouse model of retinal degenerative disease.
22 modulatory therapeutic approaches to retinal degenerative disease.
23 eral sclerosis (ALS) is a fatal motor neuron degenerative disease.
24 on of the mammalian retina following retinal degenerative disease.
25 e significant prophylactic value for retinal degenerative diseases.
26 s associated with numerous acute and chronic degenerative diseases.
27 r halting the progression of several retinal degenerative diseases.
28 as a potential therapeutic target in macular degenerative diseases.
29 nnins, which exert a protective role towards degenerative diseases.
30 , ATase1 and ATase2, for a subset of chronic degenerative diseases.
31 peripheral nervous system tumors, and common degenerative diseases.
32 in acute lung injury as well as fibrotic and degenerative diseases.
33 es for treating blindness from photoreceptor degenerative diseases.
34 r repair the damage associated with aging or degenerative diseases.
35  promising results in various autoimmune and degenerative diseases.
36 ing a range of infectious, inflammatory, and degenerative diseases.
37 ation as a means to treat human injuries and degenerative diseases.
38 nd to be associated with neural and muscular degenerative diseases.
39 for their potential use in different chronic degenerative diseases.
40 s, have been associated with reduced risk of degenerative diseases.
41 therapies to restore retinal neurons lost to degenerative diseases.
42  (THRs) can play a role in aging, cancer and degenerative diseases.
43  have a protective effect on the most common degenerative diseases.
44 tenance of outer segments, which are lost in degenerative diseases.
45 n is a pathological hallmark of many chronic degenerative diseases.
46 hly toxic lesions associated with cancer and degenerative diseases.
47 al vision in people blinded by photoreceptor degenerative diseases.
48 arious disorders, including chronic neuronal degenerative diseases.
49  occurs in inherited and age-related retinal degenerative diseases.
50 iving organisms, but also results in chronic degenerative diseases.
51 d fibrils, underlies a large number of human degenerative diseases.
52 tion of sight in patients blinded by retinal degenerative diseases.
53  cause of vision loss in retinal and macular degenerative diseases.
54 e of replacement cells to treat a variety of degenerative diseases.
55 biology and genetics of common metabolic and degenerative diseases.
56 ed in aging and the pathogenesis of numerous degenerative diseases.
57 l new therapeutic agent for treating retinal degenerative diseases.
58 ted with increased susceptibility to several degenerative diseases.
59 eatment options for certain blinding retinal degenerative diseases.
60 neurons, and pathological inclusions in some degenerative diseases.
61 loid formation, appears to cause a number of degenerative diseases.
62 rbonyls such as acrolein participate in many degenerative diseases.
63 l self-destruction in traumatic injuries and degenerative diseases.
64  could have a prophylactic value for retinal degenerative diseases.
65 force for amyloid-related toxicity in common degenerative diseases.
66 thetics offer hope for patients with retinal degenerative diseases.
67 urther drug development for treating retinal degenerative diseases.
68 sis congenita, pulmonary fibrosis, and other degenerative diseases.
69 athogenesis of inflammatory, infectious, and degenerative diseases.
70 may be a novel therapeutic target in retinal degenerative diseases.
71 ly event in adaptations linked to cancer and degenerative diseases.
72 , these changes are similar to those seen in degenerative diseases.
73 ent of therapeutic tools of inflammatory and degenerative diseases.
74 d gene therapy for treating blinding retinal degenerative diseases.
75 therapies for myofibrillar myopathy or other degenerative diseases.
76 ach for treating blindness caused by retinal degenerative diseases.
77 r and whole-animal level, autophagy prevents degenerative diseases.
78 erapeutic vaccines against cancer or chronic degenerative diseases.
79 eneration could have serious implications on degenerative diseases.
80 ulation in the genome is linked to aging and degenerative diseases.
81 cell death associated with tissue injury and degenerative diseases.
82 ment of rational treatments for debilitating degenerative diseases.
83 thophysiology, which is associated with many degenerative diseases.
84 formation, apoptosis, aging, and a number of degenerative diseases.
85 ausal roles in many types of amyloid-related degenerative diseases.
86 tion of stem cells for clinical treatment of degenerative diseases.
87 he cholesterol accumulation in NPC and other degenerative diseases.
88 ticity as a treatment for diabetes and other degenerative diseases.
89 1, has been linked to both developmental and degenerative diseases.
90 on-malignant cells in the setting of chronic degenerative diseases.
91 licating the relevance of LE to cone/macular degenerative diseases.
92 e in the pathophysiology of human cancer and degenerative diseases.
93 y, and genetic testing for inherited retinal degenerative diseases.
94 umatic injuries and drug targets for chronic degenerative diseases.
95 ntribute to cancer and many inflammatory and degenerative diseases.
96  and implicate the pathway as a modulator of degenerative diseases.
97  may link the pathogeneses of these two cell-degenerative diseases.
98 ay important roles in human inflammatory and degenerative diseases.
99 esenting new therapeutic promise for retinal degenerative diseases.
100 e stress response and may contribute to some degenerative diseases.
101 erstanding of the early pathology of retinal degenerative diseases.
102 s cancer, diabetes, autoimmune disorders and degenerative diseases.
103  protein aggregates, a hallmark of aging and degenerative diseases.
104 on, autoimmune, inflammatory, metabolic, and degenerative diseases.
105 function plays a significant role in retinal degenerative diseases.
106 ssociated with decreased risk of chronic and degenerative diseases.
107 the ER, is induced in several age-associated degenerative diseases.
108 during the lifespan as a result of stroke or degenerative diseases [4].
109 cated independently in lifespan, ageing, and degenerative disease(6,12-14)-are thus mechanistically c
110 ar-reaching consequences in the treatment of degenerative diseases, acute injury, and aging.
111  is implicated in the etiology of a group of degenerative diseases affecting bone and muscle tissue a
112 t, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
113 ore tissues or organs destroyed by injuries, degenerative diseases, aging, or cancer.
114 e pathophysiology of a wide range of chronic degenerative diseases, although inflammation has long be
115                                 In the neuro-degenerative disease amyotrophic lateral sclerosis (ALS)
116 ervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis (ALS)
117 tabolism in the pathogenesis of motor-neuron degenerative disease and identify a potential for therap
118 mise in replacing tissues and organs lost to degenerative disease and injury.
119 e association between these two hallmarks of degenerative diseases and ageing.
120 ion of autophagy has been linked to multiple degenerative diseases and cancer, thus the identificatio
121    Protein misfolding results in devastating degenerative diseases and cancer.
122 to the development of chronic autoimmune and degenerative diseases and cancer.
123 ing is the main risk factor for many chronic degenerative diseases and cancer.
124 ine and myometabolite levels may combat many degenerative diseases and delay aging.
125 ision plays a fundamental role in cancer and degenerative diseases and has been proposed to be mediat
126 athological basis for the most common muscle degenerative diseases and highlight new and encouraging
127   p97 has been implicated in the etiology of degenerative diseases and in cancer.
128 potent stem cells and is applied to model MN-degenerative diseases and in proof-of-principle drug-scr
129 omains escape regulation leading to severely degenerative diseases and represent an important therape
130 ic cell death process-is involved in various degenerative diseases and represents a targetable suscep
131 tochondrial dysfunction in acute and chronic degenerative diseases and the cellular signaling pathway
132  with reduced tissue regeneration, increased degenerative disease, and cancer.
133 igmentosa (RP) is an inherited photoreceptor-degenerative disease, and neuronal degeneration in RP is
134 sult successively in diabetes, neuromuscular degenerative disease, and perinatal lethality.
135 clerosis (ALS) is a progressive motor neuron degenerative disease, and the inherited form, familial A
136 ulticellular organisms, a critical driver of degenerative diseases, and can be harnessed for treating
137  many human diseases, including hypertrophy, degenerative diseases, and cancer.
138 its in organelle transport typical of axonal degenerative diseases, and these deficits were worsened
139 ing a central if not primary role in retinal degenerative diseases, and this association should be a
140                           Congenital retinal degenerative diseases are blinding disorders characteriz
141            Current therapies to treat muscle degenerative diseases are limited mostly to the ameliora
142                                      Retinal degenerative diseases are major causes of untreatable bl
143                                      Retinal degenerative diseases are the leading causes of blindnes
144 -i.e., selective cell-loss paradigms akin to degenerative disease-are less well defined.
145 may be especially useful in treating retinal degenerative diseases arising from rhodopsin misfolding
146 ctive drug target for the treatment of neuro-degenerative diseases as well as for brain and spinal co
147 er disparity in the development and types of degenerative diseases as well as highlighting a wide ran
148 e the leading cause of many inflammatory and degenerative diseases, as well as an important factor un
149  shares a characteristic gene signature with degenerative disease-associated microglia (DAM).
150                   A p150(Glued) motor neuron degenerative disease-associated mutation introduced into
151 progressive damage that may create different degenerative diseases at a later age.
152  show that micro-EI stimulation could affect degenerative diseases based on inflammation, implicating
153                                         Most degenerative diseases begin with a gradual loss of speci
154 ysregulated RNP granules drive neuromuscular degenerative disease but have not previously been linked
155 ators of these processes may drive cancer or degenerative disease, but are also potential therapeutic
156 therapy for mitral regurgitation (MR) due to degenerative diseases, but information on late outcomes
157      Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections,
158 tion plays a central role in various retinal degenerative diseases, but knowledge is limited regardin
159 lthough stem cells hold promise for treating degenerative diseases by 'seeding' injured tissues, the
160 rial dysfunction in the common metabolic and degenerative diseases, cancer, and aging is still debate
161 cal and inflammatory conditions that include degenerative diseases, cancer, and transplant rejection.
162                                      Retinal degenerative diseases cause photoreceptor loss and often
163            Inherited and age-related retinal degenerative diseases cause progressive loss of rod and
164 e muscular dystrophy is a progressive muscle degenerative disease caused by dystrophin mutations.
165 eich ataxia (FRDA) is an autosomal recessive degenerative disease caused by insufficient expression o
166 ystrophy (DMD) is an X-linked, lethal muscle degenerative disease caused by loss of dystrophin protei
167                                      Retinal degenerative diseases caused by photoreceptor cell death
168 h may be effective for the treatment of many degenerative diseases caused in part by the interaction
169                                      Retinal degenerative disease causing loss of photoreceptor cells
170 muscular dystrophy (DMD) is a lethal, muscle degenerative disease causing premature death of affected
171 nt optic atrophy (DOA) is a retinal neuronal degenerative disease characterized by a progressive bila
172         Abdominal aortic aneurysm (AAA) is a degenerative disease characterized by aortic dilation an
173 hic lateral sclerosis (ALS) is a devastating degenerative disease characterized by progressive loss o
174            Light-chain amyloidosis (AL) is a degenerative disease characterized by the extracellular
175 egy for the treatment of ALS and other human degenerative diseases characterized by axonal degenerati
176 acic aortic aneurysms have been labeled as a degenerative disease, characterized by alterations in ex
177 ve Rab prenylation in a model of the retinal degenerative disease choroideremia.
178                                       In the degenerative disease Duchenne muscular dystrophy, inflam
179             In contrast to inherited retinal degenerative diseases (e.g., RP), typically leading to a
180 840 patients who had MV repair for MR due to degenerative diseases from 1985 to 2004 were prospective
181 mains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP
182  the pathological cell death associated with degenerative diseases (i.e., Alzheimer's, Huntington's,
183 produce a slowly progressing skeletal muscle degenerative disease in mice.
184 nd allow for more robust modeling of retinal degenerative disease in vitro.
185 d mortality and a greater risk of developing degenerative diseases in adult life, understanding the r
186 associated with inflammatory, metabolic, and degenerative diseases in humans.
187 c progenitor cells that can be used to treat degenerative diseases in humans.
188 romote axon regeneration in injury and other degenerative diseases in the adult CNS.
189 so abnormal tissue growth such as cancer and degenerative diseases in which apoptotic caspases are at
190 at regulate autophagy or mitophagy can cause degenerative diseases in which deficient quality control
191  models of cancer and against other chronic, degenerative diseases in which inflammation and oxidativ
192 ounteracting the events that lead to certain degenerative diseases, in particular those associated wi
193 ention and management of several chronic and degenerative diseases including cancer, cardiovascular d
194                              Various retinal degenerative diseases including dry and neovascular age-
195           Autophagy is dysfunctional in many degenerative diseases including myopathies.
196  preventing vision loss secondary to retinal degenerative diseases, including age-related macular deg
197 s that are involved in a wide range of human degenerative diseases, including Alzheimer disease.
198 cause of organ failure is enigmatic for many degenerative diseases, including end-stage liver disease
199 ases, including inherited genetic disorders, degenerative diseases, inflammation, and cancer, has fue
200 have been made to extrapolate to age-related degenerative disease insights from inflammatory processe
201 MX inhibition might be useful for preventing degenerative diseases involving ferroptosis.
202 bition as a therapeutic strategy for retinal degenerative diseases involving RPE stress.
203             How neurons respond to stress in degenerative disease is of fundamental importance for id
204 ce of vascular inflammation to major retinal degenerative diseases is unresolved.
205 nherited and largely incurable photoreceptor degenerative disease, is unclear.
206 omers, the most toxic species of amyloids in degenerative diseases, is critically coupled to the inte
207 proteins for the regulation of cell death in degenerative diseases, ischemic diseases and in cancer.
208 m connecting certain iDCMs and other chronic degenerative diseases, laying the groundwork for new the
209 ore efficient therapies for defeating severe degenerative diseases like Alzheimer's is a major goal o
210 therapeutic approach in patients with muscle degenerative diseases like muscular dystrophy is that in
211 ential therapeutic strategy to treat retinal degenerative diseases like retinitis pigmentosa (RP).
212 for the treatment and prevention of blinding degenerative diseases like retinitis pigmentosa and age-
213 l to restore vision to patients with retinal degenerative diseases like retinitis pigmentosa.
214 is are associated with etiologically-diverse degenerative diseases linked to excessive extracellular
215                             The existence of degenerative diseases linked to lamin A mutations sugges
216 ed and pathogenic RNP granules that arise in degenerative diseases may be important in reducing their
217                  Wider implications are that degenerative diseases may need to be treated differently
218 ated with aging and with pathologies such as degenerative diseases, metabolic and inflammatory disord
219 on is associated with many acute and chronic degenerative diseases, mitochondrial biogenesis (MB) is
220                            In the hereditary degenerative disease myotonic dystrophy type 1 (DM1), tr
221         Osteoarthritis (OA) is a progressive degenerative disease of articular cartilage and surround
222 inal muscular atrophy, a common motor neuron degenerative disease of severity commensurate with SMN l
223 tis (sIBM) is a poorly understood immune and degenerative disease of skeletal muscle.
224       Multiple sclerosis is an inflammatory, degenerative disease of the central nervous system.
225 e sclerosis (MS), a chronic inflammatory and degenerative disease of the CNS, and in its mouse model,
226 00), genetically complex and multifactorial, degenerative disease of the cornea whose pathogenesis an
227            Best disease (BD) is an inherited degenerative disease of the human macula that results in
228    The most common cause of low back pain is degenerative disease of the intervertebral disc and othe
229 dibular joint (TMJ) osteoarthritis (OA) is a degenerative disease of the joint that can produce persi
230 eber hereditary optic neuropathy (LHON) is a degenerative disease of the optic nerve associated with
231 ings of rod loss and its link to age-related degenerative disease of the retina.
232 nd opsin, cause retinitis pigmentosa (RP), a degenerative disease of the retina.
233 ecurrent observation of TDP-43 aggregates in degenerative diseases of both the brain and muscle where
234               The presentation of the common degenerative diseases of late life, such as Alzheimer's
235 CP, an AAA-ATPase that, when mutated, causes degenerative diseases of muscle, bone and neurons.
236                                              Degenerative diseases of the autonomic nervous system in
237  a hallmark of inflammatory, infectious, and degenerative diseases of the central nervous system.
238  study brain and spinal cord inflammation in degenerative diseases of the CNS such as multiple sclero
239 mise as a useful class of drugs for treating degenerative diseases of the CNS.
240 tinitis pigmentosa is one of the most common degenerative diseases of the eye and is associated with
241                            Our findings link degenerative diseases of the kidney and retina, disorder
242                 The pathological spectrum of degenerative diseases of the mitral valve (MV) that caus
243 of proteasomal insufficiency across multiple degenerative diseases of the retina, thereby positioning
244  recover histological damage caused by neuro-degenerative disease or traumatic insults to the brain.
245 with protein mutations, as found in many CNS degenerative diseases, or chronic oxidative stress, as f
246 ng intervention for caregivers of those with degenerative diseases (parent study).
247                              In many retinal degenerative diseases, photoreceptor neurons die by apop
248 ularly in brain, is thought to contribute to degenerative disease, post-developmental interventions t
249    Transcatheter MV repair was performed for degenerative disease, present in 90.8% of patients.
250 l vascular disease; gene therapy for retinal degenerative disease; regenerative medicine, including o
251                                 Many chronic degenerative diseases result from aggregation of misfold
252 r dystrophy (DMD) is an X-linked progressive degenerative disease resulting from a mutation in the ge
253                     Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progress
254 aluated in clinical trials for the inherited degenerative disease retinitis pigmentosa (RP) and for d
255  for being repurposed to treat photoreceptor degenerative disease.SIGNIFICANCE STATEMENT Photorecepto
256 ssed, SMN deficiency causes the motor neuron degenerative disease spinal muscular atrophy (SMA).
257                       The human motor neuron degenerative disease spinal muscular atrophy with respir
258                        The motor neuron (MN) degenerative disease, spinal muscular atrophy (SMA) is c
259  RP is very similar to that of other retinal degenerative diseases such as age-related macular degene
260 ins and have been implicated in motor neuron degenerative diseases such as amyotrophic lateral sclero
261 uncontrolled degradation of collagen seen in degenerative diseases such as arthritis.
262  defects observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressiv
263 elomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibro
264               Recent work in musculoskeletal degenerative diseases such as osteoarthritis have reveal
265 ther hand, SLRP depletion is correlated with degenerative diseases such as osteoporosis and ectopic b
266 explore their therapeutic potential in neuro-degenerative diseases, such as Alzheimer's and Parkinson
267 earning and memory and may be compromised in degenerative diseases, such as Alzheimer's disease.
268                           Hereditary retinal degenerative diseases, such as retinitis pigmentosa (RP)
269                                Outer retinal degenerative diseases, such as retinitis pigmentosa (RP)
270                                      Retinal degenerative diseases, such as retinitis pigmentosa and
271 ecedes cone loss in many retinal and macular degenerative diseases, suggesting a rod-dependent trophi
272           When photoreceptors die because of degenerative diseases, surviving retinal networks are le
273 of polypeptides most notably associated with degenerative diseases termed amyloidoses.
274 andibular joint osteoarthritis (TMJ OA) is a degenerative disease that affects both cartilage and sub
275 ial corneal dystrophy (FECD) is an inherited degenerative disease that affects the internal endotheli
276 Leber congenital amaurosis, a severe retinal degenerative disease that causes blindness during infanc
277  sclerosis (MS) is a common inflammatory and degenerative disease that causes neurological disability
278  Temporomandibular joint osteoarthritis is a degenerative disease that is marked by permanent cartila
279            Retinitis pigmentosa is a retinal degenerative disease that leads to blindness through pho
280               Thyroid eye disease (TED) is a degenerative disease that manifests with detrimental tis
281 bjects with RPE65 mutation-associated IRD, a degenerative disease that progresses to complete blindne
282  congenital amaurosis, a progressive retinal degenerative disease that severely impairs sight in chil
283 mutations cause retinitis pigmentosa (RP), a degenerative disease that ultimately results in blindnes
284 n ciliopathies, a group of developmental and degenerative diseases that affect almost all organs and
285 late biochemical events in other age-related degenerative diseases that are analogous to changes asso
286 igen (Ag)-specific tolerance that can target degenerative diseases that destroy tissues and promote e
287             In the subgroup of patients with degenerative disease, the mean repair rate was 67% (n =
288 n or morphogenesis leads to blinding retinal degenerative diseases, the majority of which have a gene
289 L and MAGL inhibitors in pain, inflammation, degenerative diseases, tissue injury, and cancer.
290 city occurs during progressive photoreceptor degenerative disease to help maintain normal visual beha
291 l of prosthetics for restorative function in degenerative diseases, trauma and amputation; and even a
292 g functional vision in patients with retinal degenerative diseases, USC/Second Sight Medical Products
293 sults from vascular insults but can occur in degenerative diseases where it has typically been subsum
294                                  The retinal degenerative diseases, which together constitute a leadi
295 tis pigmentosa is a severe inherited retinal degenerative disease with a frequency of 1 in 100,000 pe
296 ithout prior cardiac disease is considered a degenerative disease with no established risk factors fo
297 itis pigmentosa (RP) is an inherited retinal degenerative disease with severe vision impairment leadi
298 y, a dominant inherited, early onset macular degenerative disease, with choroidal neovascularization
299  major challenge in the treatment of retinal degenerative diseases, with the transplantation of repla
300 profile for the treatment of chronic retinal degenerative diseases without systemic exposure.

 
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