ライフサイエンスコーパス: degradable

1 Degradable aliphatic polyesters are the cornerstones of

2 e surface ligands capable of binding to DNA, degradable aliphatic-ester dendritic scaffolds, and hydr

3 The non-degradable analogue of ATP alpha,beta-methylene ATP (alp

4 It gives a detailed summary of non-degradable and biodegradable systems and their applicati

5 The resulting P(MBL)ROP is degradable and can be readily postfunctionalized into cr

6 Degradable and cell-compatible hydrogels can be designed

7 The cryoGelMA conduit is degradable and could be completely degraded in 2-4 month

8 ppearance in the literature, a wide range of degradable and non-degradable polymers have been demonst

9 on fibroblast migration through collagenase-degradable and plasmin-degradable hydrogels and on smoot

10 arth abundant materials which are also fully degradable and recyclable.

11 oting characteristics, but it is also highly degradable and thus unsuited for several applications.

12 t the structural differences between readily degradable and undegradable micelles are rather minor, p

13 ition, a strain that expresses a temperature-degradable ATPase subunit of the 19S regulatory complex

14 gen species (ROS), is an intralysosomal, non-degradable, auto-fluorescent macromolecule which accumul

15 This liquid metal-based DDS with fusible and degradable behaviour under physiological conditions prov

16 polymers fulfill an unmet need for a readily degradable biocompatible polycarbonate.

17 this, three different types of macroscopic, degradable biomaterial hydrogel scaffolds were employed:

18 the availability of appropriate orthogonally degradable block copolymers for use as templates.

19 f drugs with SPIONs including thermo- and pH-degradable bonds, amide linkage, redox-cleavable bonds,

20 vant pharmaceutical that is otherwise poorly degradable by a bacterial community encountered in conve

21 These materials could be made non-degradable by epoxidation of the OND linkers without slo

22 gion of p73 results in a protein that is not degradable by Mdm2.

23 resulted in a p53 protein that was no longer degradable by the viral proteins.

24 Non-degradable capsules show long-term stability, whereas th

25 ading, rapidly release curcumin in vitro via degradable carbamate bonds, and retain in vitro bioactiv

26 ether, we believe that tethering proteins by degradable carbamate linkers is a promising strategy to

27 f lysozyme to poly(ethylene glycol) (PEG) by degradable carbamate linkers.

28 ial cells occurs when a surplus of an easily degradable carbon source (e.g., volatile fatty acids, VF

29 hods for green synthesis of useful naturally degradable carbon-based nanomaterials, to device operati

30 dy showed an enhanced clearance for the acid-degradable carrier, even after multiple dosing.

31 Therefore, these acid-degradable cationic nanohydrogel particles can be consid

32 nhanced in vitro gene knockdown for the acid-degradable cationic nanoparticles compared to their non-

33 uccessful application of peptide linkers for degradable cationic polymers and DNA release.

34 Degradable cationic polymers are desirable for in vivo n

35 Degradable, cationic poly(beta-amino ester)s (PBAEs) wit

36 Turnover studies using non-degradable CE and protein labels showed markedly increas

37 nd differentiation, can be controlled within degradable, cell-compatible hydrogels with temporal tuni

38 s 1.8 days (acetaminophen, ibuprofen) to not degradable (chlorthalidone, fluconazole).

39 These results suggest that the degradable Chol-PVA-PEG polymer is able to self-assemble

40 expression of either the wild-type or a non-degradable CKAP2 led to a mitotic arrest with monopolar

41 The capture-release capability of these degradable coatings is harnessed by a mixing chamber and

42 Using MMP-degradable collagen lattices or nondegradable substrates

43 drug delivery device, where air is used as a degradable component of our material to control drug rel

44 The well-degradable compounds showed slow equilibration and the l

45 n example for extremely difficult and slowly degradable compounds, CO2 production was close to the th

46 ronment, a Golden Age met with selective and degradable compounds.

47 ponents, including biodegradable polymer/non-degradable conductive polymer/dopant, biodegradable cond

48 pon Ca(2+) binding, native CaM assumes a non-degradable conformation, which most of the age-damaged s

49 When implanted subcutaneously in rats, degradable constructs containing VEGF and arginine-glyci

50 er significantly decreased toxicity over non-degradable counterparts.

51 Introduction of various degradable cross-linking agents into the system resulted

52 be present when either the degradable or non-degradable crosslinker was used.

53 t study, bioactive hydrogels with a protease-degradable crosslinker were loaded with hepatocyte and v

54 lsion polymerization with a synthesized acid-degradable crosslinker.

55 ized with either disulfide or hydrolytically degradable crosslinkers, is critical to the high efficie

56 We found that the expression of a non-degradable cyclin B in embryos also caused an anaphase a

57 d attached to the arrested spindles, and non-degradable cyclin B levels remained high on both the cen

58 proteasome inhibitor or by expression of non-degradable cyclin B, Cdk inhibitors will nonetheless ind

59 nction, principally by overexpression of non-degradable cyclin B1 or securin, we find here that separ

60 We address this issue by reporting modular degradable dendrimers that achieve the required combinat

61 hMSCs encapsulated in hydrogels with the MMP-degradable Dex-peptides had elevated levels of ALP activ

62 The degradable diblock conjugate (2P-EPI) was synthesized by

63 end, we designed second-generation backbone-degradable diblock N-(2-hydroxypropyl)methacrylamide (HP

64 olymerizable siRNA pro-drug conjugate with a degradable, disulfide linkage was prepared.

65 em consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-resp

66 , which is integrated constructed as a novel degradable drug device, demonstrates surprisingly effici

67 In addition, the hydrogel is designed to be degradable during cell culture, generating extra space t

68 ers were then thermally cross-linked to form degradable elastomeric structures.

69 A versatile method for preparing amorphous degradable elastomers with tunable properties that can b

70 classes of biologically and environmentally degradable electronic devices.

71 ess in both nondegradable gels and gels with degradable elements.

72 ly bonding the drug through a hydrolytically degradable ester linkage to a common hydrophilic polymer

73 By using these principles, we designed degradable films capable of extended release as well as

74 tion of WNT signaling by expression of a non-degradable form of beta-catenin specifically in SOX2-pos

75 contrast, neuroblasts overexpressing the non-degradable form of canonical APC/C substrates required f

76 approaches as well as expression of the non-degradable form of Cx43 significantly restore its accumu

77 t strain in which a functional but a rapidly degradable form of eIF5 fusion protein was synthesized f

78 t strain in which a functional but a rapidly degradable form of eIF6 fusion protein was synthesized f

79 escribe the effects of over-expressing a non-degradable form of geminin in various cell lines.

80 hich destabilizes the cbb(3) oxidase into a "degradable" form, perhaps by altering its conformation.

81 ild-type mouse class I MHC (H-2K(b)) but not degradable glycosylation mutants of H-2K(b) induced ER s

82 We examined a transgenic mouse in which degradable green fluorescent protein (GFP) is driven by

83 ugates and free drugs, the second-generation degradable high-molecular weight conjugates showed disti

84 results indicate that the second-generation degradable HPMA copolymer carrier can provide an ideal p

85 different therapeutic delivery systems, acid degradable hydrogels and nanoparticles.

86 n through collagenase-degradable and plasmin-degradable hydrogels and on smooth muscle cell migration

87 ochemical and physical signals in macroscale degradable hydrogels are engineered that can regulate ph

88 Finally, an enzymatically-degradable hydrogels of P(MAA-co-NVP) crosslinked with t

89 The nanocarrier-based degradable hydrogels provided controlled release of lact

90 oxyethyl methacrylate to form hydrolytically degradable hydrogels through free-radical-initiated cros

91 ight into the design of new cell-compatible, degradable hydrogels to understand and modulate cellular

92 oly(ethylene glycol) (PEG) nanocarrier-based degradable hydrogels were developed for the controlled r

93 mooth muscle cell migration through elastase-degradable hydrogels.

94 le, injectable alginate microspheres and non-degradable, implantable poly(ethylene vinyl acetate) mat

95 ct local delivery via diffusive release from degradable implants or direct intra-cerebral injection c

96 NP) formulations, and was found to be slowly degradable in phosphate buffered saline (PBS) but more r

97 The particles are fully degradable in response to esterases due to an embedded e

98 When a degradable inimer was applied, the hyper-stars showed fa

99 In this work, we engineered degradable, injectable alginate microspheres and non-deg

100 polymer/dopant or biodegradable polymer/non-degradable inorganic additives.

101 eutic antifungal agents in humans and easily degradable insecticides in agriculture.

102 in cell culture and xenograft models, a non-degradable IP3R3 mutant sensitizes tumour cells with low

103 dsRNA can be loaded on designer, non-toxic, degradable, layered double hydroxide (LDH) clay nanoshee

104 in which either disulfide-responsive or non-degradable linkages are incorporated.

105 radable nanomaterials incorporating specific degradable linkages that respond to various stimuli and

106 ubicin (DOX) to HPMA copolymer, and an MMP-2-degradable linker (PLGLAG) connected tumor-homing and -p

107 A non-degradable lipid radiolabel showed that lipid components

108 constant was independently verified using a degradable lipid radiolabel that eliminated from the bra

109 Herein, we identify promising degradable lipidoids and describe new design criteria th

110 Here, we have synthesized 1,400 degradable lipidoids and evaluate their transfection abi

111 o either free siRNA or siRNA-loaded non-acid-degradable lipoplex formulations, respectively.

112 conductive (3 x 10(5) S m(-1) ) features in degradable materials at ambient conditions over large ar

113 some contents appear degraded, but some non-degradable materials can subsequently be found in more r

114 omising strategy of utilizing 100% green and degradable materials in novel electronic and energy harv

115 shrinkage materials and preparation of (bio)degradable materials) of rROP monomer-containing materia

116 he impetus for active study of the design of degradable materials, intelligent delivery systems and a

117 Degradable matrices containing expression plasmid DNA [g

118 Here we introduce a biocompatible and degradable mesostructured form of silicon with multi-sca

119 tic (i.e., non-degradable) or dynamic (i.e., degradable) microenvironments.

120 APCs that phagocytosed the acid-degradable microgels containing ovalbumin were capable o

121 The acid-degradable microgels developed in this article should th

122 Ovalbumin is released from the acid-degradable microgels in a pH-dependent manner; for examp

123 rotecting the structural integrity of highly degradable miRNAs, providing a useful means for maintain

124 l base materials, formation chemistries, and degradable moieties is necessary to achieve the appropri

125 In addition, the injection of a non-degradable Mos (MBP-Mos) into the first cycle resulted i

126 Targeting the expression of gai (a non-GA-degradable mutant form of GAI) in the root meristem disr

127 design, synthesis and properties of backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copo

128 cently, we developed 2nd generation backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copo

129 y, which will guide the development of these degradable nanoconstructs to reach their potential for c

130 ondition in such patients, oxidation-induced degradable nanogels for iron chelation were rationally d

131 scribe the synthesis and characterization of degradable nanogels that display bulk erosion under phys

132 Thus, we have demonstrated the synthesis of degradable nanogels that erode under conditions and on t

133 lowed for the synthesis of cross-linked (bio)degradable nanogels.

134 The generality of this degradable nanoparticle formulation should allow for the

135 esized that controlled release of PHCCC from degradable nanoparticles (NPs) might address these chall

136 dental device fracture or migration, the non-degradable nature of these materials risks intestinal ob

137 utility of OND linkers in the preparation of degradable network materials with potential applications

138 BPLPs are degradable oligomers synthesized from biocompatible mono

139 ells that are chemically functionalized with degradable oligonucleotide 'Velcro', allowing rapid, spe

140 psules show long-term stability, whereas the degradable ones break down their shells, enabling the co

141 The main biotransformation product, ATO, was degradable only in aerobic conditions, as evidenced by a

142 isfolded polypeptides into harmless protease-degradable or biologically active native proteins.

143 rly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural EC

144 ies were shown to be present when either the degradable or non-degradable crosslinker was used.

145 very large numbers of ionically crosslinked (degradable or nondegradable) barrier layers cannot block

146 we have generated a toolkit of conditionally degradable or stabilisable orthologous dCas9 or Cpf1 eff

147 modulate cell response in static (i.e., non-degradable) or dynamic (i.e., degradable) microenvironme

148 of the aquifers, which is present as pyrite, degradable organic carbon, and geogenic U(IV) minerals.

149 uch as biosensors that are biocompatible and degradable over a controlled period of time can be forme

150 plicability in the characterization of other degradable particle constructs.

151 n, which may be used for the design of novel degradable pathogen-specific, and hence, environmentally

152 In vitro testing of this degradable PCL delivery platform reveals approximately 4

153 division despite the presence of nuclear non-degradable Pds1.

154 e peptide-modified, matrix metalloproteinase-degradable PEG hydrogels formed lumenized epithelial sph

155 able attention has been paid on synthesis of degradable PEI derivatives using low MW one because low

156 ry to incorporate a matrix metalloproteinase-degradable peptide crosslinker (KKCGGPQG downward arrowI

157 diacrylate derivatives with proteolytically degradable peptide sequences included in the backbone of

158 stered until released by cleavage of the MMP-degradable peptide tether triggered by cell-secreted MMP

159 -terminus of a matrix metalloproteinase(MMP)-degradable peptide, which was then easily co-polymerized

160 In this work, enzymatically degradable peptide-HPMA copolymers were synthesized by R

161 of enzymatic reaction of unstable and slowly degradable peptides with trypsin, respectively, and sugg

162 For polar and more degradable pesticides, not many data on long-term persis

163 A degradable pH-sensitive hydrazone bond between a long sh

164 icle-based DNA delivery system composed of a degradable, pH-sensitive poly-beta amino ester and poly

165 stamine (BAC) cross-linked core out of a non-degradable pNIPAM shell.

166 morphogenetic protein over several days from degradable poly(beta-amino ester) based multilayers, thi

167 ently reported the parallel synthesis of 140 degradable poly(beta-amino esters) via the conjugate add

168 capsulated in cell-adhesive, proteolytically-degradable poly(ethylene) glycol-based hydrogels.

169 ve studies of bulk samples of hydrolytically degradable poly(lactic acid) (PLA) vs core-shell block c

170 cartilage regeneration, was encapsulated in degradable poly(lactic-co-glycolic acid) (PLGA) micropar

171 We present the first well-defined degradable poly(phosphonate)s with adjustable UCST.

172 To this end, we generated a library of >500 degradable, poly(beta-amino esters) for potential use as

173 ormation of carbon dioxide and epoxides into degradable polycarbonates (CO(2)-based copolymer) has be

174 Other degradable polycationic gene carriers such as polyamidoa

175 the recent developments on these three major degradable polycations as promising carriers for deoxyri

176 le method to prepare clinically translatable degradable polyesters.1 A variety of functional groups h

177 FTOH biotransformation pathways toward more degradable polyfluoroalkylcarboxylic acids, such as 5:3

178 d within newly formulated alginate-glutamine degradable polylysine (A-GD-PLL) microcapsules.

179 NaYF4 :Tm.Yb upconverting nanocrystals in UV-degradable polymer capsules, it is possible to access ef

180 demonstrate, for the first time, a backbone-degradable polymer directly synthesized via CVD.

181 the need for an environmentally responsive, degradable polymer has risen to improve treatment outcom

182 combination of Treg inducing factors through degradable polymer microspheres (TRI microspheres; TGF-b

183 nase inhibitor, masitinib, was released from degradable polymer microspheres delivered from the surfa

184 ned coating a commercial gelatin sponge with degradable polymer multilayer films containing vancomyci

185 capsulating a single siRNA molecule within a degradable polymer nanocapsule with a diameter around 20

186 d PPF can be covalently cross-linked to form degradable polymer networks, which have been widely expl

187 catalytic activity is critical to improving degradable polymer production.

188 ion of nanoparticles formulated with an acid degradable polymer shell and encapsulated HSA exhibited

189 f chemokine ligand 22 (CCL22), composed of a degradable polymer with a proven track record of clinica

190 delivery using a far ultraviolet (UV) light-degradable polymer, which allows noninvasively triggered

191 to yield a well-defined, alkene-substituted degradable polymer, which was used as a common backbone

192 An acid-degradable polymer-caged lipoplex (PCL) platform consist

193 esign principles of traditional and backbone degradable polymer-drug conjugates as well as the develo

194 tion of mRNA for delivery to the lungs using degradable polymer-lipid nanoparticles.

195 as encapsulated in a positively charged acid-degradable polymeric nanogel to facilitate decoration of

196 uinoline-based TLR7/8 agonist to 50-nm-sized degradable polymeric nanogels the potency of the agonist

197 is study, antigens were encapsulated in acid-degradable polymeric particle carriers to cascade cytoto

198 processes have implications in the design of degradable polymers as supramolecular scaffolds for biol

199 carbonates for the realization of functional degradable polymers by ring-opening polymerisation has d

200 These cationic, degradable polymers contain pyridyldithio functionalitie

201 By this means, non cell-toxic, degradable polymers exhibiting UCST behavior in water be

202 terature, a wide range of degradable and non-degradable polymers have been demonstrated in drug deliv

203 new class of self-assembling, photo- and pH-degradable polymers of the polyacetal family is reported

204 Herein we report new degradable polymers that stabilize proteins to environme

205 al product-derived materials and functional, degradable polymers to provide a new platform for functi

206 growth factor bFGF can be incorporated into degradable polymers used as delivery devices for hepatoc

207 These degradable polymers were then employed as excipients for

208 DO), results in well-defined, hydrolytically degradable polymers, as confirmed by FTIR spectroscopy a

209 A degradable polyphosphoester (PPE)-based cationic nanopar

210 s to a tissue engineering approach that uses degradable porous material scaffolds integrated with bio

211 201 in water makes it the first example of a degradable porous solid carrier for such fumigants.

212 for adaptation with different nanoparticles, degradable pre-polymers, and various therapeutics.

213 f p53 by deletion also results in a non-Mdm2-degradable protein.

214 Expression of this non-degradable RB is found to antagonize the cytotoxic effec

215 We present here a fully degradable, remotely controlled, implantable therapeutic

216 ed SELPs with matrix metalloproteinase (MMP) degradable sequences inserted in distinct regions of the

217 rthermore, both adhesive and proteolytically degradable sequences were required for cell migration to

218 s progresses normally in the presence of non-degradable Sgo1, indicating that degradation of Sgo1 is

219 h suggests that cholesterol analogs with non-degradable side chains represent a novel class of anti-m

220 ficial hydrogel matrices presenting protease-degradable sites, cell-adhesion motifs, and growth facto

221 esterol because (i) a non-hydrolyzable and a degradable SL analog elevated cellular cholesterol to si

222 ost acts as a significant and preferentially degradable source of bioavailable carbon in Arctic fresh

223 and nonfood applications as a renewable and degradable source of carbon and energy.

224 Differently from muscle, PG in liver is a degradable source of glucose and readily depleted by fas

225 cationic nanoparticles compared to their non-degradable spermine analogues.

226 eptide binding, removal, and conversion to a degradable subfragment) are mediated by features that re

227 Bioavailability limitations of a degradable substrate can therefore either improve the ov

228 followed by transit peptide conversion to a degradable substrate.

229 safe mechanism that expands the range of RQC-degradable substrates.

230 es flanked by matrix metalloproteinase (MMP) degradable substrates.

231 h(-1), respectively), despite identical MMP degradable substrates.

232 gate several drawbacks associated with other degradable sustained delivery technologies in the market

233 success of hydroxy acid based polyesters as degradable sutures and controlled drug delivery matrices

234 rubicin, respectively, through a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-).

235 Doxorubicin was linked via a lysosomally degradable tetrapeptide sequence to N-(2-hydroxypropyl)m

236 the fabrication of conformal, hydrolytically degradable thin films capable of administering sustained

237 e PEG-LA nanocarriers with 4-arm PEG-NHS via degradable thioester bonds.

238 ilable; (2) many biocides are short-lived or degradable through abiotic and biotic processes, but som

239 building blocks known to be biocompatible or degradable to natural metabolites in vivo, are described

240 recalcitrant under anaerobic conditions but degradable under aerobic conditions can be biodegraded a

241 mechanical deformations, but are completely degradable under enzymatic action.

242 The resulting hydrogels are degradable under simulated physiological conditions and

243 y control, while incorporation of responsive degradable units enables cell- and/or user-directed degr

244 However, degradable upper critical phase separation (UCST) block

245 vector encoding a non-phosphorylatable, non-degradable variant of IkappaBalpha resulted in normal in

246 The synthesis and characterization of a degradable version of poly(acrylic acid), poly(glyceric

247 d only very slowly over multiple passages, a degradable version of the polycation was observed to mak

248 The persistence of PPs ranged from readily degradable with a dissipation half-life (DT50) as short

249 n and eventual disintegration into naturally degradable yet potentially reusable byproducts.