ライフサイエンスコーパス: degradation

1 egated Golgi membrane proteins for lysosomal degradation.

2 PFOS from both direct exposure and precursor degradation.

3 uclein in part by increasing alpha-synuclein degradation.

4 on leading to T cell activation, and (d) TCR degradation.

5 h VHL and facilitates its ubiquitination and degradation.

6 echanisms, including increased IRS-1 protein degradation.

7 regulate Wnt signaling by targeting Axin for degradation.

8 hinery required for vacuole membrane protein degradation.

9 bstrates and fast enough to prevent their co-degradation.

10 es that are highly recalcitrant to enzymatic degradation.

11 , anthracene, and Dibenzothiophene showed no degradation.

12 assembly, function, and ultimately substrate degradation.

13 target orphans of multiprotein complexes for degradation.

14 vant mixture of proteins, on Mg and Mg alloy degradation.

15 gh processes that do not involve proteasomal degradation.

16 response, mainly transcription factors, for degradation.

17 triggers its accelerated ubiquitination and degradation.

18 s PBM, which leads to its ubiquitination and degradation.

19 tipping the balance between GC formation and degradation.

20 n order to escort them to the proteasome for degradation.

21 oteinase involved in inflammation and matrix degradation.

22 it from cytoplasmic proteins that cause PTEN degradation.

23 for membrane fusion, resulting in lysosomal degradation.

24 L1 from being targeted for lysosome-mediated degradation.

25 ential bacterial taxa involved in amino acid degradation.

26 phagosomes, followed by lysosomal fusion and degradation.

27 Microwave irradiation increased product degradation.

28 ria by inducing PINK1/Parkin-dependent Miro1 degradation.

29 esses IL-27 production by promoting p28 mRNA degradation.

30 pe 1, targets NAP1L1 for proteosome-mediated degradation.

31 ike 3, targeting WNK4 for ubiquitylation and degradation.

32 BEC3 proteins and leads to their proteasomal degradation.

33 e appears to protect cyclins from precocious degradation.

34 ses of autophagosome synthesis and lysosomal degradation.

35 groups, aside from predators, decreased with degradation.

36 dicated to opposing functions: recycling and degradation.

37 f small molecules inducing selective protein degradation.

38 the clock influences the timing of onset of degradation.

39 cytic parasites, necessitating macromolecule degradation.

40 n of immature vesicles, or lysosomal vesicle degradation.

41 rgeting mitochondria into autophagosomes for degradation.

42 on product and regulates transporter protein degradation.

43 a Cnot3-dependent manner, and promoted their degradation.

44 but would also give us new insight into sRNA degradation.

45 mRNAs results in ribosome stalling and mRNA degradation.

46 d stable up to 300 degrees C with negligible degradation.

47 nd that the proteasome plays a role in RIG-I degradation.

48 into biological mechanisms of polysaccharide degradation.

49 eous aggregation and Nix-mediated mitophagic degradation.

50 tecting the receptor against agonist-induced degradation.

51 Mutations in an enzyme involved in protein degradation affect a signaling pathway that stimulates t

52 These pigments show remarkable signs of degradation after limited time periods.

53 Products of chemical degradation and compounds contained within the vesicular

54 of FOXO3a results in its nuclear export for degradation and consequent down-regulation of FOXO3a-tar

55 dysfunction at NMJs experiencing ALS-related degradation and demonstrate the potential to activate la

56 generation through nucleophagy-based LaminB1 degradation and excretion.

57 e tissue origin by blockade of nuclear FOXO4 degradation and induction of caspase-dependent apoptosis

58 (TPEN) potently blocked Vpx-mediated SAMHD1 degradation and inhibited wild-type SIVmac (simian immun

59 n has long been implicated in the process of degradation and is the primary mediator of protein turno

60 collected by a nasogastric tube and protein degradation and peptide release was compared with that f

61 ioglass 45S5 in reducing the enzyme-mediated degradation and remineralization of demineralized dentin

62 ective inhibitor facilitated mutant myocilin degradation and rescued phenotypes in a transgenic mouse

63 ly attenuated corticosterone-induced protein degradation and rescued the muscle atrophy and dysfuncti

64 ssion profiles, and 10 protein-localization, degradation and solubility tags.

65 en the lipid droplet and proteasomal protein degradation and suggest that dynamic regulation of lipid

66 some pathway was responsible for MeCP2 T158M degradation and that proteasome inhibition increased MeC

67 xin not associated with GSK3 and promote its degradation and that SIAH-mediated Axin degradation repr

68 Both matrix degradation and the number of mature invadopodia were si

69 ubiquitin ligase complex, targets DMRT1 for degradation and thereby controls the mitosis-meiosis tra

70 to protect beclin 1 from proteasome-mediated degradation and thereby enables autophagy.

71 analytical approaches enabled to quantify SM degradation and to identify how degradation controls SM

72 Evaluating pesticide degradation and transport in the soil-surface water cont

73 ing 2D crystals to prevent undesired thermal degradation and uncontrolled homogeneous nucleation, thu

74 P-1R plasma membrane recycling and lysosomal degradation and, in doing so, determine the overall beta

75 r brominated BDEs through biotic and abiotic degradation, and all age groups are exposed not only to

76 lalanine metabolism, lysine biosynthesis and degradation, and bile acid biosynthesis.

77 omatinized genomic DNA is resistant to MjAgo degradation, and recombinant histones protect DNA from c

78 on is associated with a wave of maternal RNA degradation, and the resulting relative changes to the M

79 ly targets AMPKalpha2 for ubiquitination and degradation, and thereby promotes activation of the mTOR

80 ich is a linked marker of endogenous elastin degradation, are possible biomarkers of disease severity

81 The results showed carotenoids degradation around 50% for both types of drying processe

82 rroborating previous work suggesting thermal degradation as a pathway for aldehyde generation in e-ci

83 s, we have identified the DDB1-mediated CRY1 degradation as an important target of insulin action on

84 ome-dependent turnover of ACD11 in cell-free degradation assays.

85 ent degraded after 50 days compared to 0-47% degradation at 0 degrees C (1000 m), where the aromatic

86 remodeling system is involved in HIF-1alpha degradation at the ASS1 promoter.

87 ay that could be associated with hydrocarbon degradation based on their co-occurrence with hydrocarbo

88 hibition of JAK2-mediated ferroportin (FPN1) degradation, because neither MMB treatment nor myeloid-s

89 o demethylation, absorption, deposition, and degradation before reaching the sampling site.

90 mechanisms, mainly photochemical and thermal degradation, but they only partly explain litter decompo

91 ropical rainforests are subject to extensive degradation by commercial selective logging.

92 In endosomes, CD74 undergoes sequential degradation by different proteases, including cathepsin

93 he three key cellulosic chromophores and its degradation by H2O2 is well-established, the second inte

94 film, suggesting that cell-surface collagen degradation by MT1-MMP involves DDR2-mediated collagen s

95 ADAR2 stabilizes Ctn RNA by antagonizing its degradation by PARN and HuR.

96 period coincident with extensive hemoglobin degradation by the parasite.

97 in other small Tim proteins predicts robust degradation by the protease.

98 ucleotide exchange factor Bag1 promotes hERG degradation by the ubiquitin-proteasome system at the en

99 cellular functions, including autophagosome degradation, cholesterol homeostasis, antigen presentati

100 -induced inhibition of root growth and actin degradation compared with their respective parental line

101 he definition and exemplification of protein degradation concepts and their resulting applications to

102 quantify SM degradation and to identify how degradation controls SM export at the catchment scale.

103 imal coupling of ubiquitin conjugation to ER degradation (CUE) domain in SMARCAD1 mediate their direc

104 Thus, the severity of glass-ceramic degradation depends not only on the pH of the immersed s

105 d to macrophage invasion: a defect in matrix degradation, due to a disruption of podosome rosettes ca

106 s from 13 serotypes undergo modifications or degradation during isolation and conjugation, resulting

107 mary, JB12 is a stress-sensitive Hsp40 whose degradation during severe ER stress provides a mechanism

108 contributions from photochemical and thermal degradation during the daytime.

109 s an essential role in cell migration, SMAD7 degradation, EMT, and induction of beta-catenin, and all

110 re traditionally based on microbial (biotic) degradation enabled by precipitation as the main mechani

111 med endoplasmic reticulum-associated protein degradation (ERAD).

112 velopment of metabolic machineries for their degradation, especially in microorganisms.

113 t vWF multimers (+40+/-5%, P<0.0001) and vWF degradation fragments (+53+/-6%, P<0.0001).

114 s required to select specific substrates for degradation from among the diverse complement of protein

115 We report that this degradation gives rise to strong visible photoluminescen

116 This degradation has been ascribed to the presence of seconda

117 Hemoglobin degradation/hemozoin formation, essential steps in the P

118 e protein/DNA molecule can be protected from degradation, higher local concentrations and targeted de

119 and extrinsic factors that impact vitamin C degradation in a real food matrix.

120 We further found that the block of CD74 degradation in CatS(-/-) B cells is incomplete, so that

121 ability, competitive ability and significant degradation in cell membrane and cytoplasmic structures,

122 nanticipated function for parasite lysosomal degradation in chronic infection, and identify an intrin

123 pH influenced strongly vitamin C degradation in citrate-phosphate buffer but not in the a

124 , we show that p38alpha kinase promotes EZH2 degradation in differentiating muscle cells through phos

125 le to catalyze alpha-syn phosphorylation and degradation in living cells.

126 o-Golgi transport allows the toxins to evade degradation in lysosomes.

127 adherin ubiquitination, internalization, and degradation in MDCK and peripheral bud cells for regulat

128 rf1 expression and protected sarcomeres from degradation in ncx1-deficient hearts.

129 increase TIMP-3 levels and inhibit cartilage degradation in osteoarthritis.

130 acid-indicated a high activity of tryptophan degradation in patients with active IBD.

131 ide proof-of-principle that inhibiting IP3R3 degradation in PTEN-deregulated cancers represents a val

132 d disposal of nitrogenous waste from protein degradation in the form of urea metabolism.

133 strain-induced cracking suggests mechanical degradation in the material.

134 situ chelation of PyED leads to considerable degradation in the presence of all metals within 1 h und

135 ct mechanism that may describe sudden forest degradation in the south-eastern Amazon.

136 The influence of HpRppH on RNA degradation in vivo was examined by using RNA-seq to sea

137 lysosomal fusion accompanied by augmented PV degradation in Wnt5a-treated macrophages was also appare

138 the rate and mechanisms of subsea permafrost degradation is a prerequisite to meaningful predictions

139 t our conclusion that the delay in cyclin A2 degradation is caused by low APC/C activity.

140 Lignocellulose degradation is central to the carbon cycle and renewable

141 pling between deubiquitination and substrate degradation is ensured by the Ins-1 loop of Rpn11, which

142 y promoting beta-catenin phosphorylation and degradation, it also inhibited the phosphorylation of p3

143 (optical microscopy), and ascorbic acid (AA) degradation kinetics were performed.

144 ly reported reusable sensors, such as enzyme degradation, leaching, and hysteresis effects.

145 Despite its central role in protein degradation little is known about the molecular mechanis

146 fined trafficking route to amoebic lysosomal degradation machinery.

147 proteomics technique was used to understand degradation mechanism at the protein level for the ligni

148 ced by physiological salt concentrations and degradation mediated by nucleases.

149 Three signals explained late-onset degradation: miR-430 seeds, AU-rich sequences, and Pumil

150 VirK, and four families involved in N-glycan degradation, NixE, NixF, NixL, and FucA1.

151 aerobic reductive dechlorination and aerobic degradation occurred concurrently.

152 gously expressed glucocorticoid receptor and degradation of a permanently misfolded protein, two prev

153 ivity of each system was determined from the degradation of a recalcitrant azo dye and hydroxyl radic

154 the Al-TiO2 samples were investigated by the degradation of acid orange 7 dye in aqueous solution und

155 5) are zinc metalloproteases involved in the degradation of aggrecan in cartilage.

156 hat the knockout of the Gnb5 gene results in degradation of all R7 subunits.

157 posite manner to beta-arrestin1 by promoting degradation of an unstimulated IGF-1R, but protecting th

158 Degradation of anthocyanins followed first-order kinetic

159 agents ('Seldegs') that induce the selective degradation of antigen-specific antibodies.

160 ivation to promote the shrinkage, death, and degradation of apoptotic cells.

161 prevent hyperubiquitination and proteasomal degradation of ARTs.

162 Acute inhibition or degradation of ATR in mitosis induces whole-chromosome m

163 Unexpectedly, defective lysosomal degradation of bacteria also attenuated further phagocyt

164 e widths can be generated without a dramatic degradation of beam quality within a broad range of peak

165 lter with fungus was developed for efficient degradation of benzene, which can overcome the potential

166 nhibitor dasatinib: both reduced ROS-induced degradation of beta-catenin/E-cadherin in vitro and amel

167 , that is, activation of Src/Abl kinases and degradation of beta-catenin/E-cadherin.

168 se activity that corresponded to substantial degradation of cellular RNA.

169 recent research on the capture and catalytic degradation of chemical warfare agents such as sarin and

170 lso inhibited the MT1-MMP-dependent cellular degradation of collagen film, suggesting that cell-surfa

171 The aim of this study was to evaluate the degradation of completely demineralized dentin specimens

172 electron microscopy revealed remodelling and degradation of core extracellular matrix components.

173 milar levels of (3)DOM* and (1)O2, enhancing degradation of CTC, ROX, and SMX.

174 To test the role of Gank in degradation of CUGBP1, we generated mice with liver-spec

175 Furthermore, we could measure the aerobic degradation of dissolved organic carbon (DOC) adsorbed t

176 for its function in delivery and, therefore, degradation of endocytic and autophagic cargo in lysosom

177 onsumed were generated by invertase-mediated degradation of fructan, raffinose and sucrose.

178 The degradation of geminal diazides is described.

179 egron of GS, resulting in ubiquitylation and degradation of GS in response to glutamine.

180 sequently suppressing the oxygen-independent degradation of HIF-1alpha.

181 LVAD support caused significant degradation of high-molecular-weight vWF multimers (-9+/

182 picted during in vitro fermentation showed a degradation of higher-molecular-weight phenolics over 48

183 ered intracellular trafficking and decreased degradation of HIV-1 in cocaine treated DCs.

184 genes, and the phosphorylation promotes the degradation of ICE1.

185 udy proposes a mechanism by which autophagic degradation of Id proteins can regulate cell differentia

186 osomal Cl(-) transporter ClC-b/CLCN7 delayed degradation of internalized bacteria.

187 alue in black phosphorus transistors without degradation of ION/IOFF ratio.

188 nce to annealing above 850 degrees C without degradation of its optical properties.

189 are defective in apoptosis owing to blocked degradation of Mcl-1, a pro-survival Bcl-2 family protei

190 severe changes in morphology and an overall degradation of mechanical properties in a given material

191 account when designing experiments to assess degradation of Mg-based implants.

192 es activation of Rab5 and endosomal-mediated degradation of mitochondria, suggesting cross-talk betwe

193 otein BRF1, hence resulting in the selective degradation of mRNAs.

194 Productive HspQ-Lon engagement enhances degradation of multiple new and known Lon substrates.

195 ana) COP1/SPA E3 ubiquitin ligase causes the degradation of multiple regulators of endogenous develop

196 Instead, p62 delayed the degradation of MYC mRNA by repressing the expression of

197 talled forks with a focus on the nucleolytic degradation of nascent DNA, a process commonly referred

198 least in part, by preventing aggregation and degradation of Nebulin, an essential component of the sa

199 ing oxidative stress, neuroinflammation, and degradation of neuronal architecture.

200 inhibition and to be hijacked to induce the degradation of non-native neo-substrates using bivalent

201 otential of this novel photocatalyst for the degradation of organic contaminants, and to the authors'

202 wn catalyst, the simultaneous photocatalytic degradation of organic pollutants present in the separat

203 on enhances anti-tumor immunity dependent on degradation of PD-L1 mRNA.

204 , virulence, sulfur cycle, metal resistance, degradation of plant cell wall was significantly increas

205 be the ubiquitin E3 ligase that mediates the degradation of Plk3.

206 splitting, catalysis, corrosion protection, degradation of pollutants, disinfection of bacteria and

207 anscriptional responses, we found persistent degradation of protective ECM structures called perineur

208 ellular assembly that mediates the selective degradation of proteins in the nucleus and cytosol and i

209 GCs in promoting c-src-mediated proteosomal degradation of pVHL.

210 ith glycoside hydrolases, participate in the degradation of recalcitrant carbohydrate polymers.

211 Glutathione (GSH)-induced degradation of self-immolative linkers released BENSpm f

212 n by the lipid phosphatase Ship1; and slower degradation of Ship1 co-factors.

213 yond the inventory shows that, among others, degradation of side-chain fluorinated polymers in the en

214 n of SmgGDS and promotes proteasome-mediated degradation of SmgGDS, indicating that nucleolar sequest

215 that m(6)A has important roles for inducible degradation of Socs mRNAs in response to IL-7 signalling

216 ts regulation by dormancy also depend on the degradation of specific subsets of mRNA.

217 agonizes the JAK/STAT3 signaling by inducing degradation of STAT3, a master transcription activator i

218 ssociated quality control (RQC), followed by degradation of the aberrant mRNA and polypeptide, riboso

219 mat displaced bound Foxp3, leading to prompt degradation of the dissociated Foxp3 via a ubiquitin-pro

220 ully formed moraine-dammed glacial lake, the degradation of the ice core could have implications for

221 trongly affected the stability and enzymatic degradation of the micelles.

222 rget sites within mRNAs, leading to enhanced degradation of the mRNA or inhibition of translation.

223 filament formation prevents MRE11-dependent degradation of the newly synthesized DNA at stalled fork

224 in-specific protease 7 (USP7) results in the degradation of the oncogenic E3 ligase MDM2, and leads t

225 Further, site-specific degradation of the outer ZN matrix and release of transf

226 he increase in foaming and reduction in foam degradation of the proteins highlights their use in beve

227 through the CIA pathway can be regulated by degradation of the substrate-specifying MMS19 protein an

228 D, Py-GC/MS and SEM imaging reveal extensive degradation of the wood polymers during the eight year p

229 ecently reported that ischemia induced rapid degradation of tight junction protein occludin in cerebr

230 vation of acid sphingomyelinase is linked to degradation of tight junctions in endothelial cells in v

231 ase subunit, thereby alleviating proteasomal degradation of TRF1, leading to a stable association of

232 oundwater sites as a consequence of chemical degradation of trichloroethene (TCE) by in situ minerals

233 egates showing that ClpXP is dispensable for degradation of unfolded proteins in S. aureus.

234 induced phosphorylation, internalization and degradation of VE-cadherin.

235 The aim of our study was to examine the degradation of veterinary antibiotics in milk during boi

236 KIN10-dependent degradation of WRI1 provides a homeostatic mechanism tha

237 es play a direct role in autophagy/lysosomal degradation, one of the most important pathways linked t

238 at has been reported, no obvious fingerprint degradation or lipid diffusion is observed with either g

239 sible relationship between the endolysosomal degradation pathway and autophagy on the proteolytic pro

240 Autophagy is a conserved intracellular degradation pathway and has emerged as a key mechanism o

241 sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulf

242 ression of genes involved in the chlorophyll degradation pathway.

243 Degradation percentages and rates were measured in pure

244 amination, and opacity decreasing are severe degradation phenomena affecting oil paints with zinc oxi

245 ear transcriptome, including a ribosomal RNA degradation procedure that minimizes pre-ribosomal RNA (

246 ersional analysis results indicated that the degradation process in an inert atmosphere was governed

247 maller pieces is an unavoidable stage of the degradation process.

248 otential to characterize sources, sinks, and degradation processes in the environment.

249 romatography to obtain information about the degradation processes that the building materials suffer

250 ratures, achieving greater stability against degradation processes.

251 s confirmed in this study as the actual DCAN degradation product in chlorinated drinking waters.

252 3-BRS comprising C-reactive protein, fibrin degradation product, and heat shock protein-70 improved

253 in acid extracts, coming from materials and degradation products belonging to built heritage (mortar

254 mass tandem mass spectrometry, the resulting degradation products of chloramphenicol were identified

255 ly main flame retardants but also of related degradation products or impurities has gained attention

256 status and compartment, and releases matrix degradation products.

257 carbon into microbial biomass are treated as degradation products.

258 of carotenoids and to the monitoring of its degradation profile over time.

259 LLA/nHA/AL scaffolds, and the mechanical and degradation properties of CM-ALs (10%) scaffolds were co

260 ed by non-linear regression, showed that the degradation rate of delphinidin 3-O-sambubioside was hig

261 radation was stimulated by darkness, and the degradation rate was evaluated at 63% of the ascorbate p

262 In the present study the degradation rates in soil of 11 biocides used for the pr

263 rkers thus reflects their rapid flux towards degradation rather than specific targeting to a singular

264 process, including photodegradation, thermal degradation, reactive oxidative species (ROS) oxidation,

265 is an evolutionarily conserved intracellular degradation/recycling system that is essential for cellu

266 of this ligase complex, Fbxl3, delay CRY1/2 degradation, reduce circadian rhythm strength, and lengt

267 its degradation and that SIAH-mediated Axin degradation represents an important feed-forward mechani

268 Importantly, expression of degradation-resistant EXO1 resulted in hyper-resection,

269 ta(13)C are changes in isotope ratios during degradation) resulted in clearly different LambdaC-H val

270 0(-/+) parent ions and Sb@Ni12-y@Sb20-x(-/+) degradation series in the respective LDI-TOF MS studies.

271 a hydrophobic patch, which then serves as a degradation signal.

272 we addressed these questions by identifying degradation signals in RGS2, and studying dynamic regula

273 synthetic analogues modified within the NEP degradation site ("RPRL" motif) showed improved in vitro

274 rs: actin-rich puncta coinciding with matrix degradation sites and containing proteins of the podosom

275 eactor expressed proteins involved in SCN(-) degradation, sulfur oxidation, carbon fixation, and nitr

276 strate-specific, as adaptors with artificial degradation tags were not protected even though cargo bi

277 With deforestation and degradation taking place throughout the tropics, improve

278 Degradation tests with radio or stable isotope labeled c

279 ng effects of the RNA helicase MOV10 on mRNA degradation, the potentially different ADAR1 binding beh

280 tofusin Fzo1 and that Mdm30 targets Ubp2 for degradation thereby inducing Rsp5-mediated desaturation

281 ollagen X by either autophagy or proteasomal degradation, thereby reducing intracellular accumulation

282 Targeted protein degradation through ubiquitination is an important step

283 ription, and couple RNAi-mediated transcript degradation to the establishment of H3K9me domains.

284 tured astroglioma cells, shunting tryptophan degradation toward the production of neurotoxic quinolin

285 dominant set of driving processes of iceberg degradation towards the open ocean.

286 ed carboxylic acids, which underwent further degradation under acidic conditions produced after persu

287 ring its role as a non-coding RNA processing/degradation unit.

288 Hydrocarbon degradation was faster at 5 degrees C (500 m) with 65-89

289 nder UV radiation and the efficiency of this degradation was found to be quite significant.

290 Battery degradation was monitored using impedance spectroscopy a

291 Proteasomal degradation was quantified by measuring chymotrypsin-lik

292 Ascorbate degradation was stimulated by darkness, and the degradat

293 ell as in sugar content and decreased starch degradation were observed.

294 with these results, EXO1 became resistant to degradation when its SQ motifs required for ATR-mediated

295 Our findings that the SAC prevents cyclin A2 degradation, whereas over-expressed Plk1 stimulates it,

296 most significantly to decreased chlorophyll degradation, which is supported by the reduced expressio

297 h as fungal enzymes for plant lignocellulose degradation with relevance to biotechnological applicati

298 , confirming a significant thermal transport degradation with respect to the bulk.

299 erence technique (PRT), an assay for protein degradation with two advantageous features: a reference

300 he dry season was due to nighttime microbial degradation, with considerable additional contributions