ライフサイエンスコーパス: degradative

1 . reveal a heterogeneity in lysosomal pH and degradative ability that correlates with lysosome subcel

2 e minimal host factor constraining NSP1 IRF3-degradative ability.

3 of cell types and their unique mechanisms of degradative action provide evidence that they are involv

4 ts, as exemplified by the RNA processing and degradative activities of the degradosome, to regulate t

5 rgets, providing a binding platform for mRNA degradative activities.

6 rats, septoclasts are unable to direct their degradative activity appropriately, implying a capillary

7 ing a Glu157-to-Gln mutation lost its cortex degradative activity completely.

8 The degradative activity of extracts immunoprecipitated with

9 Atg16L1, but not induction of autophagy, the degradative activity of lysosomal proteases, fusion of a

10 Another important defense mechanism is the degradative activity of macroautophagy (herein autophagy

11 ide aldehyde that competitively inhibits the degradative activity of the proteasome, had a reversible

12 c C-terminal domain (SleB(C)) exhibited high degradative activity on cortex PG in vitro, although Sle

13 es that serve to tether the requisite matrix-degradative activity to the surface of migrating cells.

14 (YpeB(N) and YpeB(C)) alone did not exhibit degradative activity, but YpeB(N) inhibited SleB(M) and

15 e its binding to eIF4H also abolish its mRNA-degradative activity, even though the mutant proteins re

16 conserved active site residues abolished its degradative activity.

17 er perturbed lysosomal pH levels may enhance degradative activity.

18 ation to control invadopodium maturation and degradative activity.

19 Degradative amino acid decarboxylation pathways in bacte

20 Lysosomes and the yeast vacuole are degradative and acidic organelles.

21 nd allows growth and development in a linked degradative and biosynthetic process known as molting.

22 Altogether, these results suggest that the degradative and cytotoxic activities exhibited by StmPr1

23 in the melanin ghosts even after exhaustive degradative and dialysis treatments, suggesting the poss

24 entified seven lysines that were attached to degradative and non-degradative forms of polyubiquitin.

25 iquitin ligase complexes and triaged between degradative and nondegradative fates.

26 ding of lysosomes; once thought to be simple degradative and recycling centers, lysosomes are now kno

27 ions between retromer and ESCRT that balance degradative and recycling functions.

28 ted, thus, providing a 'trip switch' between degradative and recycling pathways at the late-endosomal

29 of single receptors, PAR(2) and CLR, to both degradative and recycling pathways.

30 r tension combined with diffusion of general degradative and regenerative particles associated with d

31 ness to adjust the production and release of degradative and regenerative particles.

32 s by promoting local inflammatory and tissue degradative and remodeling events.

33 n level, B7-H1 molecules were stored in both degradative and unconventional secretory lysosomes.

34 tely 50% of the predicted C. japonicus plant-degradative apparatus appears to be shared with S. degra

35 dation but instead promote the generation of degradative autolysosomes, which are the endpoint compar

36 intracellular survival by inducing the bulk degradative autophagy pathway in host cells.

37 In contrast, pharmacologic modulation of the degradative autophagy pathway or genetic deletion of oth

38 How secretory autophagy diverges from degradative autophagy remains unclear.

39 iosynthesis is based in part on co-option of degradative biochemical pathways.

40 This points to a degradative but not synthetic phenotype.

41 llilysin and Tp0750 host protein binding and degradative capability is positively correlated with tre

42 When the intracellular degradative capacity is exceeded, juxtanuclear aggresome

43 In Firmicutes, degradative capacity is largely restricted to the cell s

44 pport this practical method of enhancing the degradative capacity of macrophages as a therapy for ath

45 ispose of misfolded proteins that exceed the degradative capacity of ubiquitin-proteasome and autopha

46 in Cln3(Deltaex1) (-) (6) RPE have a reduced degradative capacity that impairs the final steps of the

47 Matrix degradative capacity, three-dimensional migration throug

48 grated dual function that increases neuronal degradative capacity.

49 from Munc13-4-KO neutrophils show decreased degradative capacity.

50 h undigested membranes, indicating a reduced degradative capacity.

51 Macroautophagy (hereafter autophagy) is a degradative cellular pathway that protects eukaryotic ce

52 nd then change physical properties through a degradative, charge-neutralizing intramolecular rearrang

53 whereas SSTR-2 and -3 directed virions to a degradative compartment in which cytosol penetration was

54 l by entrapping and delivering microbes to a degradative compartment.

55 While lysosomes are degradative compartments and one of the defenses against

56 somes and basal phagolysosomes, the terminal degradative compartments of autophagy and phagocytosis,

57 ocytosis and presence of endosomal/lysosomal degradative compartments particularly enriched in Lamp-1

58 The formation of these degradative compartments requires cytosolic proteins, so

59 of autophagosomes into acidic and ultimately degradative compartments to promote their replication.

60 event that targets the channel to lysosomal-degradative compartments.

61 for acidification once endosomes mature into degradative compartments.

62 nto the endocytic system and become terminal degradative compartments.

63 and recycling and influence the delivery to degradative compartments.

64 can compete with an endogenous GR-containing degradative complex.

65 MT1-MMP/MMP14), the main invadopodial matrix degradative component.

66 aving hammerhead ribozyme to investigate the degradative consequences of an unphosphorylated 5' end.

67 levels of MFalpha transcripts in a synthetic/degradative cycle, providing a mechanism of mRNA inducti

68 This degradative effect cannot be emulated by iron or free pr

69 ly activates FGF receptor 1 (FGFR1) to exert degradative effects in both human articular chondrocytes

70 musical training provides resilience to the degradative effects of reverberation on subcortical repr

71 s (lipopolysaccharides and lipoproteins) and degradative effects of secreted bacterial proteases.

72 s via a caveolae-mediated pathway, bypassing degradative endolysosomal trafficking.

73 traffic to a nonrecycling, calpain-dependent degradative endosomal route.

74 , dissolved organic matter concentrations or degradative enzyme activities among treatments.

75 relevance consistent with an enhancement of degradative enzyme activity.

76 bacterial pathogen by functioning as both a degradative enzyme and an RNA maturase.

77 Fatty acid amide hydrolase (FAAH) is a degradative enzyme for a group of endogenous signaling l

78 onoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoy

79 onoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoy

80 mutations disrupt the maturation of a major degradative enzyme in lysosome contributing to neuropath

81 of monoacylglycerol lipase (MAGL), the major degradative enzyme of the endocannabinoid 2-arachidonoyl

82 anced due to the increased expression of its degradative enzyme, monoacylglycerol lipase.

83 HSA and carboxyl ester lipase (CEL), a PAHSA degradative enzyme, selectively hydrolyzing S-9-PAHSA.

84 well as the regulation of the production of degradative enzymes and antibiotic synthesis.

85 pment of competence and in the production of degradative enzymes and antibiotics.

86 of the biomass substrate, regulation of the degradative enzymes can be accomplished through soluble

87 and characterization of such lignocellulose degradative enzymes could be fast-tracked by availabilit

88 Use of blocking Abs and degradative enzymes demonstrated that CXCL8-stimulated f

89 re needed for maximal activity of the 1,2-PD degradative enzymes encased within the MCP shell.

90 Mining of genome data for cellulose degradative enzymes followed by experimental verificatio

91 Peptidoglycan degradative enzymes have important roles at many stages

92 spore germinants, alanine or inosine but not degradative enzymes or antibodies.

93 e S1P precursor, sphingosine kinase, and the degradative enzymes S1P lyase and S1PP phosphatase are n

94 Pathogenic bacteria secrete toxins and degradative enzymes that facilitate their growth by libe

95 road range of proteins, including toxins and degradative enzymes that play important roles in the pat

96 benefit nonpathogenic species by delivering degradative enzymes to defend an ecological niche agains

97 topentaose, which can now be acted on by the degradative enzymes, and one molecule of glucose that ca

98 ins, encompassing a diverse array of toxins, degradative enzymes, and other effectors, including nove

99 e factors including an assortment of toxins, degradative enzymes, and regulators of these compounds.

100 onoylglycerol (2-AG), their biosynthetic and degradative enzymes, and the cannabinoid (CB) receptors

101 2S system include both virulence factors and degradative enzymes, this secretion system is considered

102 hemical machinery (precursors, synthetic and degradative enzymes, transporters).

103 ation facilitates the optimal functioning of degradative enzymes, ultimately contributing to bacteria

104 d immune activation and production of tissue degradative enzymes.

105 is tightly regulated by eCB biosynthetic and degradative enzymes.

106 ("endocannabinoids") is tightly regulated by degradative enzymes.

107 pili (TFP), and multiple secreted toxins and degradative enzymes.

108 and inhibitors of individual endocannabinoid degradative enzymes.

109 re deeply understanding the evolution of new degradative enzymes.

110 ns, transporter solute-binding proteins, and degradative enzymes.

111 e resulting in the production and release of degradative enzymes.

112 cts the limiting membrane from the action of degradative enzymes.

113 the endoribonuclease SMG6 is often the first degradative event in non-sense-mediated mRNA decay (NMD)

114 e typically relegated to tissue-invasive or -degradative events.

115 The amount of RNase R, an important degradative exoribonuclease, increases 3-10-fold under a

116 ese from catabolism by diverting them from a degradative fate in lysosomes.

117 ating protein quality control systems in the degradative fate of mutant tumor suppressor proteins.

118 Collectively, our findings indicate that the degradative fate of the beta(2)AR in the lysosomal compa

119 both IgG and albumin and rescues both from a degradative fate, endowing both proteins with high plasm

120 hromosome is unknown because of the powerful degradative forces that act to decay the nonrecombining

121 es that were attached to degradative and non-degradative forms of polyubiquitin.

122 This defect impaired lysosomal degradative function causing accumulation of undegraded

123 IF4AI, and eIF4AII, suggesting that its mRNA degradative function is somehow linked to translation.

124 ction correlates directly with a loss in the degradative function of the lysosome.

125 exhibit impaired lysosomal acidification and degradative function, as well as increased cytotoxicity.

126 n of cAMP can restore an acid pH and improve degradative function.

127 nsport while FcRn is expressed but switch to degradative functions after weaning, when the jejunum do

128 f the vacuolar ATPase required for lysosomal degradative functions and autophagy, a pathway frequentl

129 Together, these combined synthetic and degradative functions ensure correct selection, extensio

130 BORC-dependent centrifugal transport for non-degradative functions of lysosomes.

131 , whose actions converge on the dynamics and degradative functions of podosome rosettes.

132 es, MHC class II-enriched organelles combine degradative functions typical of lysosomes and regulated

133 s apparently carrying out autophagy-mediated degradative functions, but where autophagy inhibition do

134 the increase was attributed to a decrease in degradative H2AX Lys48-linked polyubiquitination with a

135 ole cells, and 17AAG treatment decreased the degradative half-life of Wee1, indicating that Wee1 is a

136 strates, enzymes performing biosynthetic and degradative halogenation chemistry utilize numerous mech

137 of as the biosynthetic (i.e., anabolic) and degradative (i.e., catabolic) branches of the endomembra

138 substrate of APC(CDH1) and was modified with degradative K11-linked polyubiquitin.

139 ate endosomes unable to progress into mature degradative late endosomes and lysosomes.

140 t feature of this approach is that it allows degradative losses of contaminants to be distinguished f

141 presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination.

142 tion and melanosome biogenesis away from the degradative lysosomal pathway toward early stage melanos

143 y autophagosomes that subsequently fuse with degradative lysosomes.

144 lular and nuclear uptake, bypassing cellular degradative machinery, and improving gene expression in

145 osomal recycling can be coordinated with the degradative machinery.

146 E3 ligase, PJA2, ubiquitinates Tat in a non-degradative manner and specifically regulates the step o

147 ynamic pathway that functions primarily in a degradative manner.

148 Often regarded as a mere degradative mechanism in destruction of proteins or turn

149 Autophagy is a bulk degradative mechanism that serves to augment energy prod

150 attractive therapeutic target to counteract degradative mechanisms associated with OA.

151 S) and autophagy are two major intracellular degradative mechanisms that mediate the turnover of comp

152 es in p62 and NBR1 often suggest compromised degradative mechanisms, we found normal ubiquitin-protea

153 vatization followed by reductive cleavage, a degradative method that cleaves beta-ether bonds, indica

154 d, derived from lignin by the thioacidolysis degradative method, for structures produced when ferulic

155 Expression of inflammatory and degradative molecules was lower in chondrocytes from des

156 In spite of the degradative nature of the pathway, some pathogens are ab

157 that specific chaperones exhibit either pro-degradative or pro-folding activities.

158 oning the messengers' relevant biosynthetic, degradative, or target proteins, at all times seeking po

159 A build-up of degradative organellar by-products and decreased recycli

160 ly target lysosomes, the major intracellular degradative organelle.

161 Compromised function in lysosomes and other degradative organelles that intersect with the lysosomal

162 -related dysfunction of lysosomes, the major degradative organelles wherein Abeta localizes after upt

163 Lysosomes have traditionally been viewed as degradative organelles, although a growing body of evide

164 fective transport of vesicles, mitochondria, degradative organelles, and signaling endosomes in model

165 gy impairs axonal transport of signaling and degradative organelles.

166 Moreover, the degradative outcome of Hsc70 binding appears highly sens

167 xy substituent, reduction, N-protection, and degradative oxidation, afforded varied pyrrolidine struc

168 This degradative pathway allows partial growth of the Pex20p(

169 However, the relationship between this degradative pathway and cell death is unclear as macroau

170 MIG-14/Wntless protein aberrantly enters the degradative pathway and is depleted from the Golgi.

171 dynein/dynactin, such as trafficking in the degradative pathway and stabilization of the NMJ are lik

172 PI(4)P that maintains MT1-MMP traffic in the degradative pathway and suppresses the formation of inva

173 eals a functional link between the lysosomal degradative pathway and transport.

174 -dependent manner and that key steps in this degradative pathway are the activation of the small GTPa

175 Autophagy is a key degradative pathway coordinated by external cues, includ

176 Macroautophagy is a lysosomal degradative pathway essential for neuron survival.

177 n was due to differences in synthetic versus degradative pathway expression, we generated mice lackin

178 e possibility that a newly discovered normal degradative pathway for axons might contribute to glauco

179 ation of enzymology and gene-analysis, a new degradative pathway for caffeine has been proposed via T

180 Autophagy, a major degradative pathway for proteins and organelles, is esse

181 teasome system (UPS), the main non-lysosomal degradative pathway for ubiquitinated proteins, and auto

182 Autophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells

183 A vitamin B(6) degradative pathway has recently been identified and cha

184 l damage in vitro by inhibiting an important degradative pathway implicated in the etiology of PD.

185 Autophagy is an essential degradative pathway in neurons, yet little is known abou

186 ein-coupled receptor (GPCR) sorting into the degradative pathway is important for limiting the durati

187 Finally, we demonstrate that the proposed degradative pathway is partially reversible, showing tha

188 Autophagy is a degradative pathway necessary for differentiation, organ

189 The cellular degradative pathway of autophagy has a fundamental role

190 The function of the lysosomal degradative pathway of autophagy in cellular injury is u

191 identify an essential role for the cellular degradative pathway of autophagy in governing a balanced

192 Recently, the lysosomal degradative pathway of macroautophagy has been identifie

193 Macroautophagy is an essential degradative pathway that can be induced to clear aggrega

194 Autophagy is a cytoplasmic degradative pathway that can participate in biosynthetic

195 Autophagy is a degradative pathway that delivers cellular components to

196 Autophagy is an evolutionarily conserved degradative pathway that has been implicated in a number

197 Macroautophagy (or autophagy) is a conserved degradative pathway that has been implicated in a number

198 Autophagy is a major intracellular degradative pathway that is involved in various human di

199 Autophagy is an essential degradative pathway that maintains neuronal homeostasis

200 Autophagy is a lysosome-dependent degradative pathway that regulates the turnover of intra

201 d functionality are linked to the autophagic degradative pathway under several stress conditions.

202 and entrance of proteins into the lysosomal degradative pathway, although the mechanisms are unknown

203 slowly metabolized through the sphingolipid degradative pathway, and show limited short-term toxicit

204 ested that autophagy, the principal cellular degradative pathway, is impaired in pancreatitis, but it

205 Although autophagy is usually a degradative pathway, it also participates in biosyntheti

206 Autophagy, an intracellular degradative pathway, maintains cell homeostasis under no

207 translocated through the endosomal-lysosomal degradative pathway, rather than through the recycling p

208 Cs of knockin mice suggested a defect in the degradative pathway, which may explain the observed loss

209 es and largely avoid the endosomal/lysosomal degradative pathway.

210 R-II expression is regulated via a lysosomal degradative pathway.

211 cell surface receptors via the endolysosomal degradative pathway.

212 ts the messenger ribonucleoproteins into the degradative pathway.

213 membrane trafficking, escaping the lysosomal degradative pathway.

214 s are sequestered by the endosomal-lysosomal degradative pathway.

215 not with IGF-II, targeted the receptor to a degradative pathway.

216 nizes and sorts ubiquitinated cargo into the degradative pathway.

217 an organism for the study of this important degradative pathway.

218 specifying redirection from a recycling to a degradative pathway.

219 a key site of signal integration within this degradative pathway.

220 ting significant alterations in the cellular degradative pathway.

221 proteins, and autophagy, a lysosome-mediated degradative pathway.

222 esis or maturation and transport through the degradative pathway.

223 to sort a SNARE into COPI vesicles in a non-degradative pathway.

224 Rab35 are key elements of this use-dependent degradative pathway.

225 AT is sorted differentially to recycling and degradative pathways after psychostimulant exposure or P

226 he engineering of efficient biosynthetic and degradative pathways and gateways for genomic manipulati

227 al consequences of degradation through these degradative pathways are unknown.

228 ylates Fet3-Ftr1 and where the recycling and degradative pathways diverge.

229 h during starvation conditions; however, WTA degradative pathways have not been described for this or

230 here they are sorted and either channeled to degradative pathways or recycled to the plasma membrane.

231 ll known regulatory protein modification and degradative pathways related to iron-induced mRNA transl

232 te that TFEB enhances flux through lysosomal degradative pathways to induce APP degradation and reduc

233 ns, including the proteasomal and autophagic degradative pathways, could play a key role in the varia

234 conserved process that enables catabolic and degradative pathways.

235 tion of organic hydrocarbons and lignin-like degradative pathways.

236 g to excessive stimulation of Ca2+-dependent degradative pathways.

237 s in the sorting of APP to the recycling and degradative pathways.

238 nvolving multiple cytoplasmic chaperones and degradative pathways.

239 rface activity by diverting ADAM17 away from degradative pathways.

240 and TIMP expression, shifting from a matrix-degradative phenotype to a matrix-preserving phenotype.

241 deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A.

242 is a ubiquitin ligase (E3) for Lys48-linked degradative polyubiquitination of the same substrates.

243 (designated SM N100) are necessary for this degradative process and represent the shortest cholester

244 In other words, xenophagy, a degradative process documented after infection with HSVD

245 Autophagy is a highly conserved, degradative process in eukaryotic cells.

246 Autophagy is a self-degradative process in which cellular material is enclos

247 Atg16L1 mediates the cellular degradative process of autophagy and is considered a cri

248 been attributed primarily to its role in the degradative process of macroautophagy.

249 Autophagy is a degradative process playing a role in both cell death an

250 Autophagy is a highly conserved self-degradative process that has a key role in cellular stre

251 Autophagy is a conserved degradative process that is crucial for cellular homeost

252 Autophagy is a lysosome-dependent degradative process that protects cancer cells from mult

253 Autophagy is a cell-protective and degradative process that recycles damaged and long-lived

254 Autophagy is a degradative process that recycles long-lived and faulty

255 Autophagy is a highly conserved degradative process that removes damaged or unnecessary

256 luctuations serve as the driving force for a degradative process that requires both an unfolded cleav

257 atic physiology and the contribution of this degradative process to diseases of these organs.

258 Autophagy is a lysosomal degradative process used to recycle obsolete cellular co

259 h macroautophagy is known to be an essential degradative process whereby autophagosomes mediate the e

260 is a highly conserved, ubiquitous lysosomal degradative process, which plays an important role in ce

261 esent a point of regulatory control for this degradative process.

262 s high levels of autophagy, a conserved self-degradative process.

263 These degradative processes are better documented for inflamma

264 ne products involved in the inflammatory and degradative processes in cartilage (MMP-9, COX-2, and ca

265 er research for quantifying the magnitude of degradative processes in the environment.

266 < 0.037), potentially demonstrating parallel degradative processes in the knee.

267 L tempers proinflammatory, promigratory, and degradative processes, and through actions on endotheliu

268 , M. tuberculosis dramatically decreases the degradative processing and major histocompatibility comp

269 The bile pigment bilirubin-IXalpha is the degradative product of heme, distributed among mammals a

270 However, the degradative properties of the mature PV are unknown, and

271 ide capsule and the secretion of a myriad of degradative proteases and lipases.

272 Cancer cells form actin-rich degradative protrusions (invasive pseudopods and invadop

273 ells, triggering the formation of actin-rich degradative protrusions called invadopodia, enabling tum

274 emoval of HCHs from the surface ocean by the degradative pump due to hydrolysis and microbial degrada

275 events, suggesting an important role of the degradative pump in the overall oceanic sink of HCHs.

276 he relative importance of the biological and degradative pumps on the atmospheric deposition of the l

277 eal loading and release behavior, showing no degradative release of encapsulated salmon calcitonin in

278 Importantly, we show that this degradative response is reversible; once proper engulfme

279 In order to harness this degradative response therapeutically, we also describe a

280 e phosphorylase (PNPase) plays synthetic and degradative roles in bacterial RNA metabolism; it is als

281 show that autophagy impacts the other major degradative route involving the ubiquitin-proteasome sys

282 These degradative sites lack the punctate shape of conventiona

283 S-4 and BBS-5 disrupts the lysosome-targeted degradative sorting of ciliary sensory receptors.

284 rves additional roles in receptor recycling, degradative sorting, or constitutive secretion has remai

285 hanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.

286 d cell invasion and localizes to subcellular degradative structures termed invadopodia.

287 Functional blockade of either degradative system leads to an enhanced aggresome format

288 , but a system-wide approach to define which degradative systems are involved is lacking.

289 ed by these multiple and possibly redundant, degradative systems during fibroblast-mediated matrix re

290 tes exceeding the capacity of other cellular degradative systems.

291 Degradative thiolases, which are part of the thiolase su

292 ural elements are required for the selective degradative trafficking of S1P(1).

293 osphorylation, little is known about how non-degradative ubiquitination modulates protein structure,

294 Degradative ubiquitination of TRAF3 during MyD88-depende

295 Inhibition of degradative ubiquitination of TRAF3 prevented the expres

296 In contrast, degradative ubiquitination of TRAF3 was not affected in

297 2 interacted with Twist and promoted the non-degradative ubiquitination of Twist.

298 he incorporation of the peroxisomes into the degradative vacuole, were inhibited when either Sar1p mu

299 nocyte (KC) terminal differentiation and the degradative variability observed between light and dark

300 We hypothesize that the degradative versatility of F. succinogenes OMVs is used