ライフサイエンスコーパス: degranulate

1 rst analysis of how single cytotoxic T cells degranulate.

2 ophilic leukemia mast cells are triggered to degranulate.

3 ed by mast cells until they are activated to degranulate.

4 ylus brasiliensis, but eosinophils failed to degranulate.

5 the plasma membrane when MCs are induced to degranulate.

6 when prothrombin is activated and mast cells degranulate.

7 a fluid that accumulates in tissues when MCs degranulate.

8 and IFN-gamma production and the ability to degranulate.

9 inophils, and mast cells, many of which were degranulated.

10 were the most potent agonists for release of degranulating activity by endothelial cells when compare

11 ll line, RBL-2H3, are normally stimulated to degranulate after aggregation of high affinity receptors

12 Basophils that do not degranulate after anti-IgE challenge, known as "nonrelea

13 h cell granule ultrastructure and ability to degranulate after bacterial colonization.

14 These structures degranulate after chemical or mechanical stimuli that re

15 Cardiac mast cells degranulate after myocardial ischemia, releasing preform

16 As a consequence, Ets1(-/-) NK cells fail to degranulate after stimulation through activating NKRs.

17 NK cells degranulating against immune serum-opsonized HSV-1-infec

18 dministration of compound 48/80, a mast cell degranulating agent, restored BP disease in C4(-/-) mice

19 applications of compound 48/80, a mast cell degranulating agent.

20 f surface ADAM9, but activation of PMNs with degranulating agonists rapidly (within 15 min) increases

21 s and cytotoxic T lymphocytes (CTLs) fail to degranulate, although they retain the ability to produce

22 ith HAM/TSP (HAM/TSP patients) spontaneously degranulate and express IFN-gamma in ex vivo unstimulate

23 the proficiency of CD56(bright) NK cells to degranulate and induce chemokine and cytokine secretion.

24 thout blocking the ability of neutrophils to degranulate and kill bacteria.

25 ed the ability of LYST-deficient NK cells to degranulate and kill target cells.

26 cells from different tissues, the ability to degranulate and kill were tightly linked to PD-1 express

27 individual T cell clones can degranulate or degranulate and produce cytokine depending on the Ag con

28 hese self-renewing 'memory' NK cells rapidly degranulate and produce cytokines on reactivation.

29 These two CD4 T cell effector populations degranulate and produce IFN-gamma during steady state wi

30 ility of HIV-specific CD8 and CD4 T cells to degranulate and produce IFN-gamma, TNF-alpha, and IL-2.

31 t WASp KO NK cells had decreased capacity to degranulate and produce IFNgamma upon NKp46 stimulation

32 SCF-activated eosinophils degranulate and release eosinophil peroxidase and leukot

33 one marrow-derived mast cells (BMMC) fail to degranulate and release interleukin-6 (IL-6) following F

34 Toxoplasma gondii, mast cells were found to degranulate and release LTB4; this interaction damages t

35 Following its cross-linking, cells degranulate and release preformed inflammatory mediators

36 ells can stimulate human mast cells (MCs) to degranulate and release several cytokines.

37 tivated T cells (mvT*s) can stimulate MCs to degranulate and release several cytokines.

38 Mast cells degranulate and release the contents of intracellular se

39 f tumor Ag as measured by their inability to degranulate and secrete IFN-gamma and granzyme B.

40 s (BMMCs) were impaired in their capacity to degranulate and secrete interleukin 6 after FcepsilonRI

41 IIa-specific mAb caused skin MC(TC) cells to degranulate and secrete PGD(2), LTC(4), GM-CSF, IL-5, IL

42 ugh the pervasive actin network at the IS to degranulate and secrete their toxic contents onto target

43 of ERK and AKT, and allowed more CD8-TILs to degranulate and to produce IFN-gamma.

44 t in the ability of btk mutant mast cells to degranulate and to secrete cytokines after the retrovira

45 Eosinophils were not degranulated and increased levels of interleukin-5 were

46 Primary human KIR3DS1(+) NK cells degranulated and produced antiviral cytokines after enco

47 imeric antigen receptors (CARs) specifically degranulated and produced effector cytokines upon stimul

48 and Dryvax were highly polyfunctional; they degranulated and produced interferon gamma, interleukin

49 erimental autoimmune encephalitis, platelets degranulated and produced soluble factors serotonin (5-h

50 In vitro, mast cells degranulated and released significant TNF in response to

51 Furthermore, most of the mast cells were degranulated and spindle-shaped in patients with acute A

52 retreatment increased not only the number of degranulating and chemokine-producing mast cells but als

53 CD11b(high) phenotype, they were capable of degranulating and producing IFN-gamma upon stimulation s

54 Further, colonic eosinophils appeared to be degranulating, and the levels positively correlated with

55 problematic as islet beta cells were highly degranulated as a result of the recipients glycemic stat

56 gement of multiple activation receptors, and degranulate at levels equivalent to WT NK cells upon coi

57 K cells from CR mice produced granzyme B and degranulated at a higher frequency than CD27(-)CD11b(+)

58 nt of bone marrow-derived neutrophils, which degranulate azurophilic granules to release the Ser prot

59 l retain some capacity to cross-link IgE and degranulate basophils, however, this capacity was dimini

60 A significant proportion of degranulated beta-cells remain, at the time of diagnosis

61 ease, are recovered beta-cells that had been degranulated but present at the time of diagnosis of dia

62 reatly decreased in mast cells stimulated to degranulate by IgE.

63 ers of human dermal mast cells that could be degranulated by a number of secretagogues that activate

64 Substances degranulated by mast cells include serotonin, histamine,

65 Furthermore, the ability of NK cells to degranulate CD107a+ cytolytic vesicles was reduced (11%

66 well as the proportion of proliferating and degranulating CD8(+) T cells.

67 ranulation of mast cells, with the number of degranulated cells approaching levels observed in IgE- a

68 nted over 70% of all IFN-gamma-secreting and degranulating cells in the first 12-18 h after virus rec

69 When secreted from degranulating cells, it can interact with a variety of c

70 city of fluorochrome-labeled avidin to stain degranulating cells.

71 mber and the percent of mast cells that were degranulated compared to that after ovariectomy alone, a

72 Degranulated CTLs are surface biotinylated by the cathep

73 ace cathepsin B provides self-protection for degranulating cytotoxic lymphocytes.

74 Moreover, it had weak intrinsic degranulating effects on otherwise unstimulated Eo, prod

75 Without JNK1, mast cells fail to degranulate efficiently and release less IL-1beta after

76 ophil degranulation rate, number of duodenal degranulated eosinophil and mast cell between patients w

77 Moreover, the number of duodenal degranulated eosinophil in patients with FD were signifi

78 tor cells consisting of CD45RO+ T-cells, and degranulating eosinophils consistent with activation of

79 Degranulating eosinophils have been described in most en

80 We conclude that the abundant presence of degranulating eosinophils in the fibrous regions of endo

81 The presence of degranulating eosinophils was also associated with the p

82 plasmacytoma that is infiltrated by numerous degranulating eosinophils, would be especially sensitive

83 ression of activation markers, spontaneously degranulate ex vivo, and decrease expression of a signal

84 The characteristics of a partially purified degranulating factor isolated from conditioned supernata

85 dies indicated the presence of an additional degranulating factor not accounted for by IL-8.

86 t inflammatory cytokines induce synthesis of degranulating factors by human endothelial cells.

87 m conditioned supernatants demonstrated that degranulating factors distinct from IL8 are generated in

88 imulated with IL-1 release newly synthesized degranulating factors that require transcription and tra

89 Mast cells (MCs) similarly degranulate following Ag-dependent aggregation of the Fc

90 s profilin cleavage, which does not occur in degranulated HMC-1 mast cells, which are rich in tryptas

91 lly we present evidence that supernatants of degranulated human NK92 or primary NK cells also activat

92 on with CD4 T cells promoted accumulation of degranulated IL-4-expressing cells, but only if T cells

93 ey become phagocytically engorged, partially degranulated, immobilized, and rounded.

94 must adhere to the vessel wall, migrate, and degranulate in an ordered manner to perform their protec

95 but not the core of solid tumors, where they degranulate in close apposition to capillaries and epith

96 Although PCs failed to degranulate in infected B6 TLR9-/- mice, i.p. injection

97 e was a partial reduction in the capacity to degranulate in response to antigen, SCF was unable to en

98 d mIL-5Ralpha rendered these cells unable to degranulate in response to further IL-5 stimulation, but

99 In addition, gata2(hi) cells degranulate in response to helminth extract.

100 r levels affect the ability of mast cells to degranulate in response to IgER cross-linking.

101 SPTs demonstrate that skin mast cells do not degranulate in response to IL-33.

102 dition to PAF and lysoPAF, human eosinophils degranulate in response to lysophosphatidylcholine, but

103 phils from PAFR(-/-) bone marrow progenitors degranulate in response to PAF and lysoPAF in a manner i

104 lls efficiently produce interferon-gamma and degranulate in response to stimulation with NK cell-susc

105 and that human peripheral blood eosinophils degranulate in response to the cell-free extract of A. a

106 sis factor alpha, as well as proliferate and degranulate in response to their cognate antigenic pepti

107 are fewer in number, less mature, and do not degranulate in response to wounding as effectively as ma

108 within a few hours if they are triggered to degranulate in the presence of nontoxic thiol cathepsin

109 r by their high affinity IgE receptors, they degranulated in a pattern similar to that of WT MCs.

110 These CD57(+)NKG2C(hi) NK cells degranulated in response to stimulation through their NK

111 ter 4 to 8 weeks of culture these mast cells degranulated in response to substance P and compound 48/

112 ization was enhanced greatly when HMC-1 were degranulated in the presence of HDMEC.

113 ctivated by immunostimulatory cytokines, and degranulated in the presence of NB cells.

114 Mast cells accumulated and degranulated in the skin of young Fgfr1-/Fgfr2-deficient

115 pothesized that in I/R, neurogenic ATP could degranulate juxtaposed MC and that ecto-nucleoside triph

116 8 that fail to produce effector cytokines or degranulate late postinfection, with minimally increased

117 Although ASK mast cells degranulated less vigorously than EL mast cells upon sti

118 ggest that application of compound 48/80, to degranulate mast cells, activates the adhesion of leukoc

119 Interleukin-1Ra reduced the number of degranulated mast cells and caused a significant reducti

120 L-4, and IL-13 expression and the absence of degranulated mast cells and less influx of eosinophils w

121 However, degranulated mast cells in patients with FD were almost

122 Supernatant from degranulated mast cells increased [Ca2+]i in colonocytes

123 gand), mast cell tryptase, and a filtrate of degranulated mast cells stimulated a prompt increase in

124 Thrombin, trypsin, tryptase, a filtrate from degranulated mast cells, and peptides corresponding to t

125 the outer leaflet of the plasma membrane of degranulated mast cells.

126 ts and collagen fibers that were adjacent to degranulated mast cells.

127 arditis associated with increased numbers of degranulating mast cells (MCs) in the pericardium (26.6

128 inflammatory responses via PAR-2 and whether degranulating mast cells induced synovial hyperemia by P

129 tudies with FITC-labeled avidin demonstrated degranulating mast cells only in ischemic samples of can

130 and humans frequently contain perivascular, degranulating mast cells that release heparin.

131 We observed that the number of degranulating mast cells was graded according to the Fce

132 Immunohistochemistry suggested that degranulating mast cells were the primary source of TNF-

133 protease released from secretory granules by degranulating mast cells, converts progelatinase B to an

134 bromas, which are composed of Schwann cells, degranulating mast cells, fibroblasts, and extracellular

135 ofibromas infiltrated with a high density of degranulating mast cells.

136 issue distribution of MC and the presence of degranulated MC in various (allergic) disorders, MC-deri

137 We found no evidence that 5-HT degranulates MC or modulates IgE-dependent activation.

138 ese tumors actively attract and subsequently degranulate MCs in the pleural space by elaborating CCL2

139 Here we show that the number of degranulated MCs is increased in unwounded forearm and f

140 of recent in vivo activation (CD69, CD107a), degranulated more efficiently than did control NK cells

141 On stimulation, such CTLs degranulated more readily than other T-cell subsets, but

142 peptides (HNPs) released from activated and degranulated neutrophils inhibit proteolytic cleavage of

143 Supernatant from degranulated neutrophils killed the pneumococcus, sugges

144 Digestion by supernatants of degranulated neutrophils was blocked by an inhibitor of

145 The digestion pattern of laminin-332 by degranulated neutrophils was nearly identical to that ge

146 killing by antimicrobial factors secreted by degranulated neutrophils, but does not affect intracellu

147 reus killing among other factors secreted by degranulated neutrophils.

148 Enzymes and other factors secreted by degranulating neutrophils (polymorphonuclear leukocytes,

149 acellular chromatin traps (NETs) produced by degranulating neutrophils.

150 pecifically CD16A-expressing Jurkat T cells, degranulated NK cells, induced cytokine production and k

151 Cell-free supernatants of degranulated normal and CGD neutrophils both suppressed

152 ing a repertoire of Ly49 family members that degranulated on stimulation ex vivo.

153 rsors secreted cytokines when stimulated and degranulated on target exposure.

154 ells shows that individual T cell clones can degranulate or degranulate and produce cytokine dependin

155 rize either cytoskeletal network and fail to degranulate or release DNA.

156 Furthermore, dNK were unable to degranulate or secrete cytokines in response to HCMV-inf

157 These cells degranulated or secreted IFN-gamma, but not both, when i

158 Degranulated, P-selectin-positive platelets, however, ag

159 ybdotoxin (100 to 500 nmol/L), and mast cell degranulating peptide (1 micromol/L).

160 of HBV peptides, such as secapin, mast cell degranulating peptide, and melittin (Api m 4) were detec

161 ive peptide toxins dendrotoxin and mast cell degranulating peptide.

162 at is sensitive to dendrotoxin and mast cell degranulating peptide.

163 esions for neutrophil elastase revealed many degranulating perivascular neutrophils, with no equivale

164 ytopenia-induced tumor bleeding, circulating degranulated platelets did not.

165 In summary, (i) circulating degranulated platelets rapidly lose surface P-selectin t

166 mpared the ability of transfused resting and degranulated platelets to prevent intratumor hemorrhage.

167 for the first time in vivo that (1) infused degranulated platelets very rapidly form circulating agg

168 Circulating degranulated platelets were increased in patients with C

169 ls, and (2) 30 minutes after infusion of the degranulated platelets, the percentage of circulating mo

170 acid that is at least partially derived from degranulating platelets.

171 hypothesis that surface P-selectin-positive (degranulated) platelets are rapidly cleared from the cir

172 There was no loss of total MCs, partially degranulated plus intact, during the 4 h of observation.

173 s of active serine proteinases released from degranulating PMN.

174 ss high levels of inflammatory cytokines but degranulate poorly.

175 nulocyte-macrophage CSF, and enhanced the Eo-degranulating potencies of PAF, C5a, LTB4, and FMLP by u

176 However, CD8(+) dT degranulated, proliferated, and produced IFN-gamma, TNF-

177 Once within the brain, neutrophils degranulate, releasing destructive molecules that may ex

178 ted by recruitment of neutrophils, which can degranulate, releasing powerful proteinases responsible

179 LPS also induced the release of degranulating signals for PMNs from a human endothelial

180 e to LPS or other pathologic agonists, these degranulating signals may activate PMNs in combination o

181 MVA-043 peptide-stimulated lymph node cells degranulated similarly as assessed by Ag-induced CD107 e

182 t SHIV-immunized animals, polyfunctional and degranulating SIV-specific CD8(+) T cells were present i

183 tization and challenge, are activated by and degranulate specifically in response to PVM infection.

184 o augmented response to chemoattractants and degranulating stimuli is a characteristic feature of eos

185 ficient mast cells we show that they fail to degranulate, synthesize leukotrienes and secrete cytokin

186 t more of them secrete IFN-gamma and readily degranulate than non-ThCTL.

187 MCT in the ES stroma were more degranulated than in those with PS (median degranulation

188 ther T-cell subsets, but had a propensity to degranulate that was similar to NK cells.

189 However, when neutrophils degranulate, these proteinases are released and can caus

190 When activated to degranulate, they release a plethora of bioactive compou

191 -associated vasculitis (AAV) show mast cells degranulate, thus enhancing injury as well as producing

192 In wounds and fibrotic lesions, mast cells degranulate to release tryptase, and thrombin mediates b

193 5AC revealed a significantly higher ratio of degranulated to nondegranulated GCs after the ITN (IB: 2

194 hough control subjects had a higher ratio of degranulated to nondegranulated GCs at baseline (0.75 +/

195 The ratio of degranulated to nondegranulated GCs was measured as a ma

196 competently produced effector cytokines and degranulated upon Ag reencounter.

197 produced very large amounts of IFN-gamma and degranulated upon TCR activation.

198 s and RBL-2H3 cells, a mast cell model which degranulates upon cross-linking of the high-affinity imm

199 te that MCs react to vaccinia virus (VV) and degranulate using a membrane-activated pathway that lead

200 se subsets display a cytotoxic phenotype and degranulate when challenged with primary acute myeloid a

201 Isolated myocytes also degranulated when incubated with oxytocin (P<0.0001), bu