ライフサイエンスコーパス: degron

1 proteins act as degradation determinants (N-degrons).

2 substrate sequences that affect degradation (degrons).

3 ted repertoire of known degradation signals (degrons).

4 of the presence or absence of its N-terminal degron.

5 ires phosphorylation of TFAP4 on a conserved degron.

6 c retention determinant and an Asi-dependent degron.

7 F(Cdc4) after phosphorylation of a multisite degron.

8 post-translationally modified to expose an N-degron.

9 g3, direct ligands of Cog1, can repress this degron.

10 OG complex, is also shown to contain an Ac/N-degron.

11 ClpS and eluted with a peptide bearing an N-degron.

12 emonstrating that C21 constitutes a portable degron.

13 r domain, an adjacent linker sequence, and a degron.

14 UBR1 targets CUP9 through its internal degron.

15 pe GADD34, thereby identifying an N-terminal degron.

16 ls its stability through a conserved phospho-degron.

17 ndogenous protein genomically with the auxin degron.

18 old) with the addition of a protease-cleaved degron.

19 correct spacing are insufficient as a KEAP1 degron.

20 s for specific substrate sequence motifs, or degrons.

21 dation of related substrates with C-terminal degrons.

22 minantly the destruction (D) box and KEN box degrons.

23 itions that shield and unshield natural Ac/N-degrons.

24 o of 37 determined N-terminal peptides had N-degrons.

25 as essential components of degrons, called N-degrons.

26 to inhibit degradation of proteins without N-degrons.

27 ing affinity-based proteomics with synthetic degrons.

28 ydrophobic) N-terminal residues as part of N-degrons.

29 ollowing recognition of sequence tags called degrons.

30 trol (PQC)-specific and compartment-specific degrons.

31 for large-scale identification of eukaryotic degrons.

32 struction through a motif termed the "methyl degron."

33 tated the recruitment of Fbw7 to the phospho-degron (1361) pSPKLpS(1365) of topoIIalpha, leading to i

34 74A T393A)) and report that ablation of both degrons abolished regulation of cyclin E by Fbw7.

35 Evaluating degron activity in the context of a ubiquitination-resis

36 vivo ubiquitination analyses indicated that degron activity is ubiquitin-independent.

37 rved proline residue (Pro-221) is central to degron activity, and mutation to alanine (P221A) increas

38 n the ETS domain and the second is a cryptic degron adjacent to the serum response factor (SRF)-inter

39 e variation in a hypervariable region of the degron affects JAZ stability and JA-regulated physiologi

40 ns engineered to contain the auxin-inducible degron (AID) are selectively degraded upon adding auxin.

41 Recently, a plant auxin-inducible degron (AID) system has been shown to degrade AID-tagged

42 d a derivative expressing an auxin-inducible degron (AID)-tagged version of the protein have been use

43 We used a novel degron allele to inactivate Mcm10 efficiently and this b

44 We created a novel Pan1-degron allele, Pan1-AID, in which Pan1 can be specifical

45 To this end, we use a fusion between a degron and an inactivating peptide that can be added to

46 ClpS binds the substrate N-degron and assembles into a high-affinity ClpS-substrate

47 scherichia coli, the adaptor ClpS binds an N-degron and delivers the protein to ClpAP for degradation

48 e ligand-inducible phosphorylation of IFNAR1 degron and enables binding of betaTrcp to the receptor.

49 Ivarepsilon phosphorylates the S102 in this degron and promotes SPOP-dependent turnover of SRC-3.

50 How coactivators recognize D box degrons and how this is inhibited by APC/C regulatory pr

51 ate specific degradation signals termed Ac/N-degrons and targeted by the Ac/N-end rule pathway.

52 lear antigen-interacting protein-degron (PIP-degron) and that knockdown of the components of the CRL4

53 rally, model UPS substrates having different degrons, and aggregation-prone proteins associated with

54 Coactivators recognize substrate degrons, and enhance the affinity of the APC/C for its c

55 Although there are variations in components, degrons, and hierarchical structures, the proteolytic sy

56 3 degron contains two canonical Cdc4 phospho-degrons, and the phosphorylation of each of these is req

57 by many E3s constitute an important class of degrons, and these are almost always present in disorder

58 nd selectivity determinants encoded in APC/C degrons, and we describe some of the extrinsic mechanism

59 Substrates carrying N-degrons are recognized by N-recognins that mediate ubiqu

60 Specific N-terminal amino acids (N-degrons) are sufficient to target a protein to the degra

61 ocessing signal, the linker sequence and the degron, are ineffective.

62 y, a set of N-terminal amino acids, called N-degrons, are recognized and ubiquitinated by the UBR pro

63 sheet, instead of recognizing short peptides/degrons as often seen in other F-box protein-substrate c

64 Our findings exemplify N-end rule degrons as tools to unravel functions of a single protei

65 human thymidylate synthase is directed by a degron at the polypeptide's N-terminal end, composed of

66 nd exposed by oxidation do not function as a degron, because they are not sufficient to convert a non

67 and demonstrate that many noncanonical APC/C degrons bind APC/C coactivators at the D box coreceptor.

68 Both types of N-degrons bind its ZZ domain.

69 Degron binding regulates the activities of the AAA+ Lon

70 Degron binding to multiple sites in the Lon hexamer appe

71 site-directed UBR1 mutations narrow down the degron-binding activity to a 72-residue UBR box-only fra

72 vities, general architectures, and substrate degron-binding modes.

73 gron binds the DegP active site, and another degron binds a separate tethering site in PDZ1 in the cr

74 One degron binds the DegP active site, and another degron bi

75 cular determinants not only in the substrate degron but also on PCNA.

76 Thus, CAT-tails do not serve as a degron, but rather provide a fail-safe mechanism that ex

77 sequent phosphorylation of IFNAR1 within its degron by CK1 alpha.

78 oteins with N-end rule degradation motifs (N-degrons) by ClpAP while blocking degradation of substrat

79 nts (N-recognins) as essential components of degrons, called N-degrons.

80 N-degrons can also be generated through modifications of p

81 cence protein modified by carboxyl fusion of degron CL1) and bona fide (CryAB(R120G)) misfolded prote

82 charomyces cerevisiae using a transplantable degron, CL1 (1).

83 a UPS reporter protein consisting of a short degron, CL1, fused to the COOH-terminus of green fluores

84 providing the first example of a cholesterol-degron collaboration.

85 Deltaubl1 mutant to recognize an N-end rule degron confirmed involvement of UBL1 in the N-end rule p

86 the ability of these regions to function as degron constituents.

87 Forced localization of the degron constructs revealed that proteolysis mediated by

88 The polo kinase Cdc5-derived degron contained an essential KEN motif, whereas a singl

89 s present, and are not encoded solely by the degron-containing domain II.

90 he ER is required for the degradation of CL1 degron-containing proteins.

91 The SfIAP degron contains mitogen-activated kinase (MAPK)-like reg

92 The Hst3 degron contains two canonical Cdc4 phospho-degrons, and

93 s (i.e. post-translational modifications or "degrons") contribute to its UPD.

94 ted for destruction during S phase via a PIP degron, contributing to oscillations of Dap protein accu

95 he two beta-TrCP-binding sites to serve as a degron could be both increased and decreased by manipula

96 Of note, the earliest known Doa10 yeast degron, Deg1, also contains an amphipathic helix and exh

97 Degron-dependent depletion of Taf1, Taf2, Taf7, Taf11, a

98 Degron-dependent Npa3 depletion resulted in genome-wide

99 sible for turnover of YfgM and find that the degron does not at all comply with the known N-end rule

100 Mutation of the Hst3 diphospho-degron does not completely stabilize Hst3 in vivo, but i

101 irus Gn-Ts, the TULV Gn-T lacks a C-terminal degron domain and failed to bind tumor necrosis factor (

102 raction with PCNA through a specialized "PIP degron" domain targets it for PCNA-coupled CRL4(Cdt2)-de

103 he GSK3beta-mediated phosphorylation of CHD1 degron domains, which promotes CHD1 degradation via the

104 s, the energy of binding of linked substrate degrons drives assembly of the proteolytic machine respo

105 of Pih1 contains multiple destabilization or degron elements.

106 -TrCP), since deletion or mutation of either degron eliminated degradation.

107 SCF(Slmb) interacts with a phosphor degron embedded within the human and fruitfly SMN YG-box

108 on the location of their degradation signal/degron: ERAD-L (lumen), ERAD-M (membrane), and ERAD-C (c

109 s the capacity for recognizing intramembrane degrons, expanding its spectrum of substrates.

110 ated on three serine residues in a conserved degron, facilitating binding and degradation via the F b

111 osphorylated on three serines in a conserved degron, facilitating binding and ubiquitylation by the F

112 e, highlighting the conservation of critical degron features from yeast to humans.

113 the N-acetyl-Met residue of Hcn1, a putative degron for the Doa10 E3 ubiquitin ligase, is inaccessibl

114 N-end rule to create a temperature-sensitive degron form of avian Orc6.

115 The sul20 degron from the cell-division inhibitor SulA is shown he

116 Doa10 recognizes the Deg1 degron from the MATalpha2 transcription factor.

117 signed two Protacs that contain the peptide 'degron' from hypoxia-inducible factor-1alpha, which bind

118 Whereas ubiquitin-dependent degrons have been characterized in some detail, how prot

119 ems based on generation and recognition of N-degrons have been observed in all eukaryotes and prokary

120 A variety of alternative APC/C degrons have been reported, suggesting either that multi

121 otein for degradation, collectively known as degrons, have been defined for many proteins involved in

122 However, repositioning of AD2-adjoining degrons (i.e. DSGLS-containing SDS1 and PEST2 sequences)

123 rmed by the next 15 residues, functions as a degron, i.e. it is capable of destabilizing a heterologo

124 Here we describe an entirely new degron identified in the cytoplasmic N-terminal end of t

125 represent the shortest cholesterol-regulated degron identified to date.

126 estroyed via its activated (unshielded) Ac/N-degron if the total level of Cog1 increased in a cell.

127 to the SPOP-mediated degradation because of degron impairment.

128 ymphomas, aggregate within an amino-terminal degron important for proteasomal destruction of MYC, and

129 POP interacts directly with an SRC-3 phospho-degron in a phosphorylation-dependent manner.

130 Plk1 phosphorylates a conserved DSGxxT degron in Bora and promotes its interaction with beta-Tr

131 Phosphorylation of the betaTrCP degron in DEPTOR is executed by CK1alpha after a priming

132 Direct cadmium sensing at the ER by a degron in Pca1 leads to an escape of Pca1 from ERAD.

133 is coupled to DNA replication via a specific degron in Set8 that binds PCNA.

134 Additional HOX paralogs share the conserved degron in the homeodomain and are also subject to CUL4-m

135 re detail in vivo we used an auxin inducible degron in which Mcm10 is degraded upon addition of auxin

136 Thus, the mechanisms producing N-degrons in proteins and the frequency of their occurrenc

137 ll these data show the critical role of both degrons in regulating cyclin E activity and reveal that

138 Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin from t

139 Furthermore, the absence of analogous degrons in virus-encoded IAPs explains their relative st

140 To identify the ClpX degradation tag (degron) in HsdR, we used bioinformatics and biochemical

141 udies show that the JAZ1 degradation signal (degron) includes a short conserved LPIAR motif that seal

142 inds type-1 and type-2 N-terminal degrons (N-degrons), including arginine (Nt-Arg).

143 Phosphorylations within N- and C-terminal degrons independently control the binding of cyclin E to

144 hosphorylation of Thr464 present in the CDT2 degron inhibits recognition by FBXO11.

145 The YfgM degron is a distinct module that facilitates FtsH-mediat

146 erated degradation conferred by the Cdt1 PIP degron is accompanied by more effective Cdt2 recruitment

147 ation but not the identity of the processing degron is critical.

148 Our findings support a model wherein the degron is exposed when SMN is monomeric and sequestered

149 interaction of TDG with PCNA through the PIP degron is required for targeting TDG to the CRL4(Cdt2) E

150 y ClpS-substrate-ClpA complex, but how the N-degron is transferred from ClpS to the axial pore of the

151 PR-Set7 mutant in its "PIP degron" is now detectable during S phase, during which t

152 djoins the basic amino acid of the bound PIP degron, is dispensable for substrate binding to PCNA but

153 The Degron-KI system allows for highly specific, inducible,

154 results demonstrate the broad utility of the Degron-KI system for the functional characterization of

155 The Degron-KI system was able to faithfully recapitulate the

156 -mediated knock-in of inducible degron tags (Degron-KI) that provides a versatile approach for the fu

157 hosphorylation of Ser(535) within the IFNAR1 degron leading to recruitment of beta-Trcp E3 ubiquitin

158 not only activates Chk1, but also exposes a degron-like region at the carboxyl terminus of Chk1 to a

159 (Cdh1) becomes active and contains conserved degron-like sequences common to APC substrates, suggesti

160 Degron-like sequences of the MCC subunit BubR1 block deg

161 The degron likely responds to virus-induced kinase-specific

162 Molecules containing hydrophobic degrons linked to small-molecule AR ligands induce AR de

163 teins based primarily on degradation signal (degron) location.

164 Intriguingly, the degron maps to the Sbh2 TM region.

165 By the degron-mediated depletion of Pta1, we show that the remo

166 y the result of viral IAP evolution in which degron-mediated destabilization and ubiquitination poten

167 m, including a modification of the regulated degron method, which allows rapid and specific degradati

168 el of NKX3.1, suggesting that treatment with degron mimetics may be a viable approach for NKX3.1 rest

169 egradation of wild-type ERG by recognizing a degron motif at the N terminus of ERG.

170 teins (BRD2, BRD3 and BRD4) by recognizing a degron motif common among them.

171 tions increase affinity between TIR1 and the degron motif of Aux/IAAs and enhance the activity of the

172 the Thr-1695 site in a putative CDC4 phospho-degron motif of rictor; mutation of this site impaired t

173 Interaction between the phosphorylated degron motif of TRIM9 and the WD40 repeat region of beta

174 itical S303 residue in the KLF5 Cdc4 phospho-degrons motif ((303)SPPSS) abolishes the protein interac

175 mulation required activator interaction with degron motifs on the substrate.

176 Although well characterized degron motifs such as the destruction box (D-box) and KE

177 alysis confirmed this interaction and mapped degron motifs within ASPP2, which are required for Siah2

178 f full-length SMN are also stabilized in the degron mutant background.

179 Expression of a PIP degron mutant Dap attenuates endocycle progression but d

180 Failure to degrade DEPTOR through either degron mutation or betaTrCP depletion leads to reduced m

181 e motif in IAA28 resembled plants expressing degron mutations, underscoring the functional relevance

182 gnin that binds type-1 and type-2 N-terminal degrons (N-degrons), including arginine (Nt-Arg).

183 gt1 is cotargeted for degradation, through a degron near its N terminus, by 2 ubiquitin-mediated prot

184 observation that fusing Deg1, a cytoplasmic degron normally recognized by Doa10, to the Sec62 membra

185 Furthermore, the Ac/N-degron of Ac-MQ-Rgs2 was conditional, and Teb4, an endop

186 hway, which recognized a C terminus-proximal degron of Chk1.

187 ate-binding site of UBR1 targets an internal degron of CUP9, a transcriptional repressor of peptide i

188 mide, and pomalidomide, recognizes an acetyl degron of GS, resulting in ubiquitylation and degradatio

189 These two sites are located within a degron of SRC-3 and are primary determinants of SRC-3 tu

190 Phosphorylation of the degron of the IFNAR1 chain of the type I interferon (IFN

191 cations of posttranslationally exposed pro-N-degrons of otherwise stable proteins; such modifications

192 trong positive cooperativity between the two degrons of securin.

193 and define the degradation signal sequence (degron) of HOXB4 required for CUL4-mediated destruction.

194 APC/C(Ama1) recognizes two degrons on Cdc20p, the destruction box and destruction d

195 mechanism that involves display of substrate degrons on the DNA polymerase processivity factor PCNA.

196 recognizes short linear sequence motifs, or degrons, on its substrates.

197 g different repressible promoters, inducible degrons, or their combinations were developed.

198 Binding of acetylated degron peptides to CRBN depends on an intact thalidomide

199 major were also capable of increasing IFNAR1 degron phosphorylation in cells.

200 zed ATF4 mutants exhibit decreased beta-TrCP degron phosphorylation, beta-TrCP interaction, and ubiqu

201 ligase that is recruited to IFNAR1 upon its degron phosphorylation, which is induced by the ligand.

202 ing cell nuclear antigen-interacting protein-degron (PIP-degron) and that knockdown of the components

203 in mechanical protein degradation, show that degron placement can change whether unfolding or translo

204 ning N-terminal degradation signals called N-degrons, polyubiquitylates these proteins, and thereby c

205 ning N-terminal degradation signals called N-degrons, polyubiquitylates these proteins, and thereby c

206 Here, we use a Shld1-stabilized degron-POT1a fusion (DD-POT1a) to study the telomeric AT

207 residues essential for the action of the PIP degron prevent the ubiquitination and degradation of TDG

208 hase expression of a Set8 mutant lacking the degron promotes premature H4K20me1 accumulation and chro

209 Here we identify three degron proximal lysine residues, Lys-315, Lys-330, and L

210 udy shows how APC/C inhibition is coupled to degron recognition by co-activators.

211 The MCC inhibits the APC/C by obstructing degron recognition sites on Cdc20 (the substrate recruit

212 ike sequences of the MCC subunit BubR1 block degron recognition sites on Cdc20, the APC/C coactivator

213 n two conserved ClpS1 residues involved in N-degron recognition.

214 d be associated with protein degradation and degron recognition.

215 llin-RING catalytic subunits relative to the degron-recognition module of coactivator and APC10.

216 strates and discuss that substrate elements (degrons) recognized by E3 ligases are highly disordered:

217 Degradation signals (degrons) recognized by these ubiquitin ligases remain po

218 hown to be orthogonal and active in exposing degrons, releasing inhibitory domains and cleaving polyp

219 undamental intrinsic characteristics of this degron remain unknown.

220 our findings suggest that the SfIAP phospho-degron responds rapidly to a signal-activated kinase cas

221 d we demonstrate that this regulation of the degron's activity is critical for IkappaBalpha's signali

222 Finally, we show that this degron's activity is regulated by the interaction with N

223 s is likely to be modulated by variations in degron sequence and context.

224 Tiam1 to the F-box protein betaTrCP via its degron sequence and subsequent Tiam1 ubiquitylation and

225 ity hormone binding requires a bipartite JAZ degron sequence consisting of a conserved alpha-helix fo

226 ized by the F box protein, betaTrCP, via its degron sequence for subsequent ubiquitination and degrad

227 d that the amino terminus of BRCA1 harbors a degron sequence that is sufficient and necessary for con

228 DMRT1 contains a consensus beta-TrCP degron sequence that was found to bind beta-TrCP.

229 r, these results identify the first specific degron sequence within a native i-AAA protease substrate

230 The juxtaposition of degron sequences and E2F interaction motifs appears to b

231 ropose that this unique property of the Acm1 degron sequences results from an unusually high affinity

232 bstrates generally contain one or more short degron sequences that help mediate their recognition and

233 age-specific targeting of SAMHD1 N-terminal "degron" sequences.

234 CP, by RSK1/S6K1 inhibition, and by betaTrCP degron site mutations.

235 ion of CK1 and MEK, or mutation of the Tiam1 degron site.

236 osolic protein DeltaMTS-Aco1 tagged with the degron SL17 (a ubiquitin-proteasome substrate).

237 Fusion of the degron (SlNAC1(191-270) ) containing these 10 amino acid

238 defect creates a potent degradation signal (degron; SMNDelta7-DEG) at SMNDelta7's C-terminal 15 amin

239 phagy through its binding Nt-Arg and other N-degrons.Soluble misfolded proteins that fail to be degra

240 tion are possible or that our definitions of degron structure are incomplete.

241 Bacterial ClpS is involved in N-degron substrate selection and delivery to the ClpAP pro

242 A+ ClpAP protease to recognize and degrade N-degron substrates.

243 e we describe minimal degradation sequences (degrons) sufficient for rapid APC/C-Cdh1-specific in viv

244 uced a phenotype consistent with loss of the degron, suggesting an as-yet-unidentified recognition pa

245 FBW7 recognizes a conserved degron surrounding threonine 236 (T236) in SOX9 that is

246 Using the auxin-inducible degron system in mouse embryonic stem cells, we show tha

247 nd resection in vivo, using a heat-inducible degron system that allows rapid conditional depletion of

248 Using an improved degron system we show that without Elg1, PCNA accumulate

249 eously eliminated, using the auxin-inducible degron system.

250 The degron tag can be efficiently introduced by CRISPR/Cas9-

251 mediates robust auxin-dependent depletion of degron-tagged targets.

252 r CRISPR/Cas9-mediated knock-in of inducible degron tags (Degron-KI) that provides a versatile approa

253 ast, for the AAA+ Lon protease, we show that degron tags are also regulatory elements that determine

254 t residue could act as a degradation signal (degron), targeted by the Doa10 ubiquitin ligase.

255 While an N-terminal degron targets Pca1 for degradation before its secretion

256 diverse functions contained these N-terminal degrons, termed AcN-degrons, which are a prevalent class

257 n plants to characterize motifs flanking the degron that contribute to tuning the dynamics of Aux/IAA

258 acetylated at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and

259 This creates a diphosphorylated degron that is necessary for Hst3 polyubiquitylation by

260 a substrate, and this is mediated by an Ebp2 degron that is phosphorylated by glycogen synthase kinas

261 the APC/C ubiquitin ligase, contains an Ac/N-degron that is repressed by Cut9, another APC/C subunit

262 cyclin C-Cdk8 association and serves as the degron that mediates ubiquitin ligase SCF(Grr1)-dependen

263 We show that the Rbf1 IE is an autonomous degron that stimulates both Rbf1 ubiquitination and repr

264 radation required both of its two C-terminal degrons that are recognized by the ubiquitin ligase SCF(

265 verse insects carry unique signal-responsive degrons that control IAP turnover.

266 Here we identify and characterize degrons that mediate the degradation of the Hedgehog pat

267 Many of these create degradation signals (N-degrons) that mediate protein destruction via the N-end

268 tion site, Ser-280, located within the CIITA degron, that regulate CIITA ubiquitination, stability, a

269 trates contain recognition motifs, so-called degrons, that direct them to the appropriate protease.

270 , and sequences outside of the characterized degron (the minimum region required for auxin-induced de

271 Functioning as a protein degron, the cellular IAP leader dramatically shortened t

272 and structural clarity to the concept of the degron, the portion of a protein that determines its sus

273 In both degrons, the APC/C recognition motif was flanked by a nu

274 dc20) protein, directly interacts with APC/C degrons--the destruction (D) and KEN boxes.

275 in a manner similar to that described by the degron theory of transcriptional activation.

276 ex by optimally positioning the Mad3 KEN-box degron to bind Cdc20.

277 Fusing Cdt1's PIP degron to p21 causes p21 to be destroyed nearly concurre

278 ion, and a system using CRY2 and a LOV-fused degron to simultaneously block transcription and deplete

279 -box, and the recently identified ABBA motif degrons to Cdh1.

280 oup of the first residue were critical for N-degrons to properly interact with the UBR proteins.

281 ploy the demonstrated conditionality of Ac/N-degrons to regulate subunit stoichiometries and other as

282 -1V or ANDV GnTs and that mutations that add degrons to TULV or PHV GnTs confer TRAF3 binding.

283 These findings define a structural degron underlying cereblon 'neosubstrate' selectivity, a

284 Phosphorylation of the BimEL degron was executed by Rsk1/2 and promoted by the Erk1/2

285 SOD1 binds a C-terminal degron we identified in Yck1p/Yck2p and promotes kinase

286 onstruction of a knockin mouse in which both degrons were mutated by threonine to alanine substitutio

287 ltiple destabilization factors and acts as a degron when fused to other proteins.

288 st that 570-kDa UBR4 and 300-kDa UBR5 bind N-degron, whereas UBR3, UBR6, and UBR7 do not.

289 mma is abolished by removal of SDS1 or PEST2 degrons, whereas production of the cleaved 85-kDa Nrf1 i

290 CRL4(Cdt2) targeting motif known as the PIP degron, which binds DNA-loaded proliferating cell nuclea

291 Thus, CRL4(Cdt2) recognizes an unusual degron, which is assembled specifically on chromatin via

292 ntained these N-terminal degrons, termed AcN-degrons, which are a prevalent class of degradation sign

293 CRL4(Cdt2) substrates contain a "PIP degron," which consists of a canonical proliferating cel

294 appaBalpha contains an ubiquitin-independent degron whose activity is portable to heterologous protei

295 Lon recognizes HspQ via a C-terminal degron, whose precise presentation, in synergy with mult

296 Cdc20p, the destruction box and destruction degron, with either domain being sufficient to mediate C

297 led by a conserved phosphorylation-sensitive degron within the IAP N-terminal leader.

298 gases frequently use lysines adjacent to the degron within the substrate, many substrates can be targ

299 Degrons within AD1 do not promote proteolytic degradatio

300 T binding to TRAF3 is mediated by C-terminal degrons within NY-1V or ANDV GnTs and that mutations tha