ライフサイエンスコーパス: dehalogenation

1 is an active oxidant in halophenol oxidative dehalogenation.

2 ons also result in a decrease in the rate of dehalogenation.

3 electron transfer as start of the reductive dehalogenation.

4 azoles, as a result of reduced propensity to dehalogenation.

5 function as a proton donor during reductive dehalogenation.

6 ironments often build on microbial reductive dehalogenation.

7 biodegradation and zerovalent metal-mediated dehalogenation.

8 d through haloglycosylation and a subsequent dehalogenation.

9 ments, methyl-group transfers, and reductive dehalogenation.

10 ross-coupling reactions as well as reductive dehalogenations.

11 at the core was designed to prevent in vivo dehalogenation, a potential problem for radiohalogens in

12 The dehalogenation ability of wild-type Mb is augmented in t

13 Finally, only minimal differences in dehalogenation activities are seen among the exogenous l

14 The hexachloroethane dehalogenation activity of CYP101 has been investigated

15 zed and because of known problems with quick dehalogenation after internalization of antibodies, we d

16 ions (beta-alkylation, beta-aminoalkylation, dehalogenation, amine arylation, and decarboxylative rad

17 Despite the number of methods available for dehalogenation and carbon-carbon bond formation using ar

18 hus leading to simultaneous enantioselective dehalogenation and deamination to form the corresponding

19 t in most of the reported conditions used in dehalogenation and deoxygenation processes.

20 heir relative thermodynamic stability toward dehalogenation and how different substitution patterns g

21 and overall transformations involved in the dehalogenation and isomerization reactions are strikingl

22 ide degradation is the rate-limiting step to dehalogenation and mineralization of the lampricide.

23 cross-coupling reactions, such as reductive dehalogenation and Suzuki-Miyaura reactions.

24 d (aerobic C-Cl bond cleavage via hydrolytic dehalogenation), and -57 +/- 3 per thousand and -77 +/-

25 on), 0.7 +/- 0.1 and 0.9 +/- 0.1 (hydrolytic dehalogenation), and 1.76 +/- 0.05 and 3.5 +/- 0.1 (diha

26 otope fractionation was smaller in enzymatic dehalogenation, and dual-element isotope slopes (2.2-2.8

27 nt role in both hexachloroethane binding and dehalogenation, and hexachloroethane binding and dehalog

28 Enzymatic reactions, such as isomerisation, dehalogenation, and methyl transfer, rely on the formati

29 ated cyclizations to C-C bond constructions, dehalogenations, and H-atom abstractions.

30 active mutant for hexachloroethane reductive dehalogenation at pH 7.4 was F87W-V247L (80 min-1 or 2.5

31 aid in understanding the bacterial reductive dehalogenation at the molecular level.

32 O reduction at the Cu2O surface, followed by dehalogenation at the Pd using the in situ generated H2.

33 and/or kinetic differences in catalytic PCE dehalogenation by enzymes and different corrinoids, wher

34 In this study, carbon tetrachloride (CT) dehalogenation by the chloride form of GR (GRCl) was tes

35 oethane binding while increasing the rate of dehalogenation by up to 40% at pH 6.5, suggesting that t

36 aqueous alkaline solution (pH 8); reductive dehalogenation by zero-valent iron nanoparticles (nZVI)

37 In this study, we examined the dehalogenation capability of each strain to use chlorobe

38 role of the corrinoid cofactor in reductive dehalogenation catalysis by tetrachloroethene reductive

39 o examine whether the mechanism of oxidative dehalogenation catalyzed by C. fumago chloroperoxidase (

40 Furthermore, the initial rate of dehalogenation catalyzed by Mb Cpd II is nearly comparab

41 A (CoA) were required to stimulate reductive dehalogenation, consistent with the intermediacy of 2-ch

42 in the context of electro-organic synthesis (dehalogenation, deoxygenation) of pharmaceutically relev

43 e and mechanism of nature's halogenation and dehalogenation enzymatic strategies, highlights gaps in

44 ecause the accumulated evidence for cis-CaaD dehalogenation favored a mechanism involving direct subs

45 ed into 2-iodo serinyl glycosides which upon dehalogenation gave C-2 deoxy amino acid glycoconjugates

46 bond cleavage, acceptorless dehydrogenation, dehalogenation/hydrogen transfer, oxidation and reductio

47 g pharmaceuticals from associated isomers or dehalogenation impurities can sometimes be quite difficu

48 was investigated during anaerobic reductive dehalogenation in methanogenic laboratory microcosms.

49 dehalogenases are responsible for biological dehalogenation in organohalide respiring bacteria, with

50 hanism of DHP-catalyzed oxidative halophenol dehalogenation involves two consecutive one-electron ste

51 Mb Cpd II is an active oxidant in halophenol dehalogenation is consistent with a traditional peroxida

52 ggest that halide expulsion during reductive dehalogenation is initiated through single electron tran

53 Although reductive dehalogenation is key to their environmental and enginee

54 Reductive dehalogenation is not typical of aerobic organisms but p

55 Such a reductive dehalogenation is uncommon in aerobic organisms, and its

56 We report bioreactor performance and dehalogenation kinetics of a D. mccartyi-containing cons

57 2-2.8) were distinctly different compared to dehalogenation mediated by corrinoids (4.6-7.0).

58 ples is presented including decarboxylation, dehalogenation, nucleophilic addition, dimerisation, oxi

59 us was expressed in tobacco resulting in the dehalogenation of 1,2-dichloroethane, which was otherwis

60 lyophilized enzyme powders for the gas-phase dehalogenation of 1-bromopropane.

61 Reductive dehalogenation of 1a was found to predominate in photoin

62 Complete dehalogenation of 20 mg L(-1) trichloroethylene was achi

63 lective addition of the radical derived from dehalogenation of 21 at the beta carbon of the (Z)-alpha

64 A-CoA) dehalogenase catalyzes the hydrolytic dehalogenation of 4-CBA-CoA by attack of Asp145 on the C

65 A-CoA) dehalogenase catalyzes the hydrolytic dehalogenation of 4-CBA-CoA to 4-hydroxybenzoyl-CoA (4-H

66 A-CoA) dehalogenase catalyzes the hydrolytic dehalogenation of 4-CBA-CoA to 4-hydroxybenzoyl-CoA by u

67 A-CoA) dehalogenase catalyzes the hydrolytic dehalogenation of 4-CBA-CoA to 4-hydroxybenzoyl-CoA by u

68 fcb gene cluster involved in the hydrolytic dehalogenation of 4-chlorobenzoate is organized in the o

69 or activity in the formation of dTMP and the dehalogenation of 5-bromo- and 5-iodo-dUMP.

70 The rate of dehalogenation of 5-bromo-2'-deoxyuridine 5'-monophospha

71 ost N229 mutants exhibit no activity for the dehalogenation of 5-bromo-dUMP, which requires correct o

72 e mutants catalyzed the cofactor-independent dehalogenation of 5-bromodUMP; hence, the Asp side chain

73 reductive dehalogenases were involved in the dehalogenation of all tested brominated benzenes, includ

74 Two mechanisms for the aqueous dehalogenation of aromatics involving nucleophilic aroma

75 yl chlorides and bromides, for the catalytic dehalogenation of aryl chlorides, and for the catalytic

76 ns: Suzuki-Miyaura cross-coupling, catalytic dehalogenation of aryl halides, and aryl amination.

77 utants as catalysts for cofactor-independent dehalogenation of BrdUMP, a reaction which simulates ear

78 shown to catalyze the glutathione-dependent dehalogenation of bromoacetate with a k(cat)/K(m) value

79 uster is CprA, which catalyzes the reductive dehalogenation of chlorinated aromatic compounds.

80 pproach to published experimental results on dehalogenation of chlorinated ethenes both in well-mixed

81 ted isotope enrichment factors for microbial dehalogenation of chlorinated ethenes vary considerably

82 imes have rarely been explored for reductive dehalogenation of chlorinated ethenes.

83 modeling approach we focus on the reductive dehalogenation of chlorinated ethenes.

84 es that can derive energy from the reductive dehalogenation of chlorinated organic compounds, many of

85 that some fraction of the cis-CaaD-catalyzed dehalogenation of cis-3-haloacrylates also proceeds by c

86 logenase (cis-CaaD) catalyzes the hydrolytic dehalogenation of cis-3-haloacrylates to yield malonate

87 halogenase lowers the activation barrier for dehalogenation of DCE by 2-4 kcal/mol relative to the si

88 The title fluoroalkene has been generated by dehalogenation of dibromide and diiodide precursors and

89 They catalyze the hydrolytic dehalogenation of either trans- or cis-3-haloacrylates t

90 re able to conserve energy via the reductive dehalogenation of halo-organic compounds in a respiratio

91 AtzA was shown to exclusively catalyze dehalogenation of halo-substituted triazine ring compoun

92 ornata is designed to catalyze the oxidative dehalogenation of halophenol substrates.

93 DHP catalyzes the H(2)O(2)-dependent dehalogenation of halophenols.

94 as also been shown to catalyse the reductive dehalogenation of hexachloroethane and pentachloroethane

95 ty through a highly enantioselective radical dehalogenation of lactones-a challenging transformation

96 diverse microorganisms couple the reductive dehalogenation of organohalides to energy conservation.

97 d from a chemostat study where the reductive dehalogenation of PCE was evaluated in the absence and p

98 ts in a graphene lattice by a stoichiometric dehalogenation of perchlorinated (hetero)aromatic precur

99 The reductive dehalogenation of perchloroethylene and trichloroethylen

100 Dehalogenation of perophoramidine (1) by ammonium format

101 w halogen substitution may form from in situ dehalogenation of PHCZs having more halogens.

102 genation, the scope of the catalyst includes dehalogenation of polychlorinated benzenes, bromobenzene

103 Dehalogenation of TCE resulted in a similar extent of C

104 Thus, Cys13 is required for the reductive dehalogenation of TCHQ.

105 quinone dehalogenase catalyzes the reductive dehalogenation of tetrachloro- and trichlorohydroquinone

106 ternative nor-B12 cofactor--were applied for dehalogenation of tetrachloroethene (PCE) or trichloroet

107 quinone dehalogenase catalyzes the reductive dehalogenation of tetrachlorohydroquinone and trichloroh

108 quinone dehalogenase catalyzes the reductive dehalogenation of tetrachlorohydroquinone and trichloroh

109 c acid dehalogenases catalyze the hydrolytic dehalogenation of the cis- and trans-isomers of 3-chloro

110 between Cys13 and glutathione formed during dehalogenation of the substrate.

111 nas pavonaceae 170, catalyzes the hydrolytic dehalogenation of trans-3-chloroacrylate in the trans-1,

112 We report the electrocatalytic dehalogenation of trichloroethylene (TCE) by single soft

113 thway in which the products of the oxidative dehalogenation of trihalophenols (dihaloquinones) are th

114 s, none of the analogues underwent oxidative dehalogenation or glutathione adduction.

115 the discovery of an enantioselective radical dehalogenation pathway for alpha-bromoesters using flavi

116 The 4-chlorobenzoyl-CoA dehalogenation pathway in certain Arthrobacter and Pseud

117 A) in the final step of the 4-chlorobenzoate dehalogenation pathway.

118 y these two bacterial strains via dissimilar dehalogenation pathways and discuss the underlying mecha

119 CBDB1 and environmental fate modeling of the dehalogenation pathways.

120 logenation, and hexachloroethane binding and dehalogenation places conflicting demands on active-site

121 ated) vinyl radicals formed in the reductive dehalogenation process should be reduced to the correspo

122 nol system used in radical deoxygenation and dehalogenation processes has been investigated.

123 era known to be involved in halogenation and dehalogenation processes such as Bradyrhizobium or Pseud

124 Suzuki-Miyaura cross-coupling and catalytic dehalogenation processes, affording yields similar to th

125 Different effects on CF suppression and CT dehalogenation rate were expected because of the differe

126 linearly correlated with CF suppression and dehalogenation rate.

127 d hexachloroethane binding but increased the dehalogenation rate.

128 imiting step in the I12S and I12A enzymes is dehalogenation, rather than the thiol-disulfide exchange

129 owed that only S167A and S167G catalyzed the dehalogenation reaction and values of k(cat)/K(m) for th

130 ll three active site catalysts catalyzed the dehalogenation reaction as well as or better than the wi

131 th CCPO-I and -II to carry out the oxidative dehalogenation reaction is consistent with a mechanism i

132 cs simulations have been carried out for the dehalogenation reaction of the nucleophilic displacement

133 The dehalogenation reaction pathway shares at least two dire

134 xidize trihalophenols to dihaloquinones in a dehalogenation reaction that uses hydrogen peroxide as a

135 n is the rate-limiting step in the reductive dehalogenation reaction under physiological conditions.

136 ctions may be similar, the final step in the dehalogenation reaction, a thiol-disulfide exchange reac

137 steps in the initial stages of the reductive dehalogenation reaction.

138 gle proton is partially rate-limiting in the dehalogenation reaction.

139 o position for the hydrolysis portion of the dehalogenation reaction.

140 chloromethane and, like F(430), can catalyze dehalogenation reactions and produce lower halogenated p

141 The thermodynamic constraints of aromatic dehalogenation reactions are thus important for understa

142 Surface-confined dehalogenation reactions are versatile bottom-up approac

143 The dehalogenation reactions could be turned over with catal

144 alogenase catalyzes two successive reductive dehalogenation reactions in the pathway for degradation

145 high activity for alpha-ketone arylation and dehalogenation reactions of activated and unactivated ar

146 ing physiologically relevant deamination and dehalogenation reactions, respectively.

147 This reactivity was utilized to facilitate dehalogenation reactions, the reduction of electron-poor

148 bic microorganisms rarely catalyze reductive dehalogenation reactions.

149 nyl as a small model system, we describe the dehalogenation, recombination, and diffusion processes.

150 l classes of environmental contaminants, and dehalogenation remains one of the most important process

151 tion in all natural and engineered reductive dehalogenations reported to date suggesting that OS-SET

152 nB catalyzing HCl elimination and hydrolytic dehalogenations, respectively, as initial steps in the m

153 echanism and factors affecting the undesired dehalogenation side reaction were revealed.

154 1,3-DCB or 1,2-DCB, demonstrated the widest dehalogenation spectrum of electron acceptors tested, an

155 ed the maximum rate (k(max)X) value for each dehalogenation step remained fairly constant, while hupL

156 For example, (1) a dehalogenation Suzuki-Miyaura cross-coupling sequence de

157 an operationally simple, tin-free reductive dehalogenation system utilizing the well-known visible-l

158 of halogenated alkenes is impeded by partial dehalogenation taking place during the hydroboration pro

159 evels traces the temperature of the onset of dehalogenation to around 475 K.

160 , and 2-iodothiophenes undergo photochemical dehalogenation via the triplet state.

161 to the TCE loss, suggesting that contaminant dehalogenation was the primary loss fate.

162 ichloroethene (TCE), and compared to abiotic dehalogenation with the respective purified corrinoids (

163 4-dichlorobenzoyl-CoA, NADPH-dependent ortho dehalogenation yielding 4-chlorobenzoyl-CoA, hydrolytic