ライフサイエンスコーパス: dehydratase

1 iosynthetic enzyme delta-aminolevulinic acid dehydratase.

2 sopropylmalate isomerase, a key iron-sulphur dehydratase.

3 nase, and a possible NAD-dependent epimerase/dehydratase.

4 This superfamily includes 2-methylcitrate dehydratase.

5 e 3-dehydroshikimate (3-DHS) by AsbF-a 3-DHS dehydratase.

6 amino acid biosynthesis enzyme dihydroxyacid dehydratase.

7 scherichia coli chorismate mutase-prephenate dehydratase.

8 thione peroxidase, and 4 alpha-carbinolamine dehydratase.

9 demonstrate that the RiDD is in fact a diol dehydratase.

10 l as enzymatic assay of B(12)-dependent diol dehydratase.

11 ing arginine deiminase and a putative serine dehydratase.

12 vitro inhibitor of an AdoCbl-dependent diol dehydratase.

13 trolling the catalytic efficacy of scytalone dehydratase.

14 s164, in the active site of dTDP-glucose 4,6-dehydratase.

15 lose homolog CYP71A12, also encoding an IAOx dehydratase.

16 ocalization of the Arabidopsis epimerase and dehydratase.

17 the Ser-derived enamine/imine product of Thr dehydratase.

18 serine hydroxymethyltransferase, and serine dehydratase.

19 e the MoFe-nitrogenase and 2-hydroxyacyl-CoA dehydratases.

20 found in a large protein family of epimerase/dehydratases.

21 of homologous nucleotide sugar epimerases or dehydratases.

22 in the reaction catalyzed by K164M and T134A dehydratases.

23 ts into substrate recognition by lantibiotic dehydratases.

24 it belongs to a third subfamily of inverting dehydratases.

25 '-phosphate (PLP)-dependent serine/threonine dehydratases.

26 may impact the binding of ISO and TAC to the dehydratases.

27 in the regulatory domain of ADT2 (arogenate dehydratase 2).

28 del of the Escherichia coli dTDP-glucose-4,6-dehydratase (4,6-dehydratase) active site has been gener

29 r the reaction catalyzed by dTDP-glucose 4,6-dehydratase (4,6-dehydratase) has been determined by rap

30 glucose by Escherichia coli dTDP-glucose 4,6-dehydratase (4,6-dehydratase) takes place in the active

31 coli, including the oxidative conversion of dehydratase [4Fe-4S] clusters to an inactive [3Fe-4S] fo

32 Mg534 is a 4,6-dehydratase 5-epimerase; its three-dimensional structure

33 lori mutants deficient in 6-phosphogluconate dehydratase (6PGD) were constructed.

34 pendent glycerol dehydratase by the glycerol dehydratase activating enzyme results in formation of 5'

35 are discussed within the context of the 4,6-dehydratase active site model and chemical mechanism.

36 ichia coli dTDP-glucose-4,6-dehydratase (4,6-dehydratase) active site has been generated by combining

37 overy of epidermal 4a-OH-tetrahydrobiopterin dehydratase activities and physiologic 7BH(4) levels in

38 nal enzymes, SimC7, was proposed to supply a dehydratase activity missing from two modules of the pol

39 equired for the stability or function of the dehydratase activity of the elongase system.

40 eron was derepressed unmasking the threonine dehydratase activity of the threonine synthase ThrC.

41 tramer, displays pterin-4alpha-carbinolamine dehydratase activity, and binds HNF1alpha in vivo and in

42 domains were also found to possess intrinsic dehydratase activity, whereas the conventional DH domain

43 d/or phenylpyruvate route in which arogenate dehydratase (ADT) or prephenate dehydratase, respectivel

44 very/deduction that a six-membered arogenate dehydratase (ADT1-6) gene family encodes the final step

45 Plant PPA-ATs and succeeding arogenate dehydratases (ADTs) were found to be most closely relate

46 t it is the enzyme delta-aminolevulinic acid dehydratase (ALA-D) and that it does not contain detecta

47 me 9q34) codes for delta-aminolevulinic acid dehydratase (ALAD) (E.C. 4.2.1.24).

48 The structures of 5-aminolaevulinic acid dehydratase (ALAD) complexed with substrate (5-aminolaev

49 iosynthesis enzyme delta-aminolevulinic acid dehydratase (ALAD) is normally repressed by the Irr prot

50 modification by a delta-aminolevulinic acid dehydratase (ALAD) polymorphism.

51 5-Aminolaevulinic acid dehydratase (ALAD), an early enzyme of the tetrapyrrole

52 new assay of human delta-aminolevulinic acid dehydratase (ALAD), an enzyme converting delta-aminolevu

53 al co-regulator of delta-aminolevulinic acid dehydratase (Alad), but not 5-aminolevulinate synthase g

54 rocess is catalyzed by 2-hydroxyglutaryl-CoA dehydratase, an enzyme with two components (A and D) tha

55 ted that epidermal 4a-OH-tetrahydrobiopterin dehydratase, an important enzyme in the recycling proces

56 reatment rapidly inactivated isopropylmalate dehydratase, an iron-sulfur cluster enzyme in this pathw

57 nockdown of the nonredundant hydroxyacyl-CoA dehydratase and enoyl-CoA reductase enzymes in the ELO p

58 All plant NAD(P)HX dehydratase and epimerase sequences examined had predict

59 parum presents homologues of GDP-mannose 4,6-dehydratase and GDP-L-fucose synthase enzymes that are a

60 ed versions of P. falciparum GDP-mannose 4,6-dehydratase and GDP-L-fucose synthase expressed in trans

61 two genes: TGDS encoding the TDP-glucose 4,6-dehydratase and GPR180 encoding the G protein-coupled re

62 l that encases coenzyme B(12)-dependent diol dehydratase and perhaps other enzymes involved in 1,2-pr

63 n genes encoding delta-aminolevulinate (ALA) dehydratase and porphobilinogen deaminase, the second an

64 (residues 101-386) containing the prephenate dehydratase and regulatory domains, and (c) R12, a C-ter

65 type sequences for 4a-OH-tetrahydrobiopterin dehydratase and therefore ruling out the previously susp

66 Although dehydratase and thioesterase activities are known activi

67 Escherichia coli dTDP-glucose 4,6-dehydratase and UDP-galactose 4-epimerase are members of

68 how that AprD4 is the first radical SAM diol-dehydratase and, along with AprD3, is responsible for 3'

69 resent in the activator of 2-hydroxyacyl-CoA dehydratases and a ferredoxin-like [2Fe-2S] cluster doma

70 atases differ from mammalian L- and D-serine dehydratases and bacterial D-serine dehydratases by the

71 e thus provisionally classified as arogenate dehydratases and designated ADT1-ADT6.

72 hermore, these mutant proteins are excellent dehydratases and provide useful tools to investigate the

73 GL) lactonase, 6-deoxy-6-sulfogluconate (SG) dehydratase, and 2-keto-3,6-dideoxy-6-sulfogluconate (KD

74 ) and has distinct UDP-GlcNAc 4-oxidase, 5,6-dehydratase, and 4-reductase activities.

75 lase, hyaluronan synthase, GDP-D-mannose 4,6 dehydratase, and a potassium ion channel protein.

76 majority of the cell's B(12)-dependent diol dehydratase, and additional unidentified proteins.

77 he homologous mandelate racemase, l-fuconate dehydratase, and d-tartrate dehydratase, the active site

78 us far, the identities of the ketoreductase, dehydratase, and enoyl reductase remain a mystery becaus

79 thetic enzymes chorismate mutase, prephenate dehydratase, and prephenate dehydrogenase in cell extrac

80 model, they are completely conserved in 4,6-dehydratase, and they differ from the corresponding equa

81 mponents-an elongase protein (Elop), a novel dehydratase, and two reductases-catalyzed repeated round

82 es UDP-galactose epimerase, dTDP-glucose-4,6-dehydratase, and UDP-xylose synthase in oxidizing the C-

83 ke UDP-galactose epimerase, dTDP-glucose-4,6-dehydratase, and UDP-xylose synthase.

84 ation, the oxidation of [4Fe-4S] clusters of dehydratases, and DNA damage.

85 ion of a putative methionine salvage pathway dehydratase, apoptotic protease activating factor 1 (APA

86 fusions showed that Arabidopsis RidA and Thr dehydratase are chloroplast targeted.

87 Several specific dehydratases are known to catalyze the first proposed st

88 The reaction mechanisms for these types of dehydratases are quite complicated with proton abstracti

89 The [4Fe-4S]2+ clusters of dehydratases are rapidly damaged by univalent oxidants,

90 Hydroxyacyl-coA dehydratases are required for elongation of very long ch

91 ) clusters found at the active sites of many dehydratases are susceptible to damage by univalent oxid

92 em supported the activity of 1,2-propanediol dehydratase as effectively as authentic adenosylcobalami

93 The combination of a dehydratase assay with a high-resolution crystal structu

94 (1.12 +/- 0.06 g L(-1)) in the presence of a dehydratase at 44% and 87% yield of fed propionate, resp

95 ssfully produced in E. coli by employing the dehydratase BsjM and the dehydrogenase NpnJA.

96 may not only attack the [4Fe-4S] clusters in dehydratases, but also block the [4Fe-4S] cluster assemb

97 yl radical on the B(12)-independent glycerol dehydratase by the glycerol dehydratase activating enzym

98 D-serine dehydratases and bacterial D-serine dehydratases by the presence of an iron-sulfur center ra

99 polyketide synthase (PKS) has the predicted dehydratase catalytic domain in modules 1, 2, and 5 requ

100 The dTDP-glucose 4,6-dehydratase catalyzed conversion of dTDP-glucose to dTDP

101 CDP-D-glucose 4,6-dehydratase catalyzes the conversion of CDP-D-glucose to

102 GDP-D-mannose 4,6-dehydratase catalyzes the first step in the de novo synt

103 idopsis thaliana encodes a GDP-D-mannose 4,6-dehydratase catalyzing the first step in the de novo syn

104 e heat-induced genes is the serine deamidase/dehydratase Cha1 known to be regulated by increased seri

105 l hydroquinone by the reductase ClaC and the dehydratase ClaB.

106 nvestigation, GDP-4-keto-6-deoxy-d-mannose-3-dehydratase (ColD), catalyzes the third step in the path

107 ine synthase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD), respectively.

108 h are components of the beta-hydroxyacyl-ACP dehydratase complex that participates in the mycolic aci

109 rolysis of ATP to deliver an electron to the dehydratase component (CompD), where the electron is use

110 he inducible pathway and D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase (D-PBE) of

111 Arabidopsis thaliana biosynthetic threonine dehydratase/deaminase (TD), to the CaMV 35S promoter and

112 nical diagnosis of delta-aminolevulinic acid dehydratase-deficient porphyria, a rare enzymatic defici

113 have additive effects on 6-phosphogluconate dehydratase-dependent growth during nitrosative stress,

114 other or both isoforms of GDP-D-mannose 4,6-dehydratase, depending on the cell type and/or developme

115 Dehydratase (DH) catalytic domains play an important rol

116 The dehydratase (DH) domain of module 4 of the 6-deoxyerythr

117 R) domain of EpoC and then dehydrated by the dehydratase (DH) domain to produce the methylthiazolylme

118 ss-link ACPs with catalytic beta-hydroxy-ACP dehydratase (DH) domains by means of a 3-alkynyl sulfone

119 Dehydratase (DH) domains of cryptic function are often f

120 The dehydratase (DH) domains of PKSs, which generate an alph

121 The dehydration that is catalyzed by the dehydratase (DH) domains of TYLS module 2 to give the un

122 yl-ACP thioesterase, a ketoreductase (KR), a dehydratase (DH), and an enoyl reductase (ER).

123 odule may also include a ketoreductase (KR), dehydratase (DH), and/or enoyl reductase (ER) domain.

124 PICS module 2 is a dehydratase (DH)-containing module that catalyzes the fo

125 We targeted the development of a dehydratase (DH)-specific reactive probe that can facili

126 tep in the de novo pathway, 3-dehydroquinate dehydratase (DHQ), was deleted.

127 third enzyme in the pathway, dehydroquinate dehydratase (DHQD), catalyzes the dehydration of 3-dehyd

128 The dehydratases (DHs) of modular polyketide synthases (PKSs

129 Bacterial L-serine dehydratases differ from mammalian L- and D-serine dehyd

130 etion in PCBD1 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear

131 n, a deletion mutant of MAB_4780, encoding a dehydratase, distinct from the beta-hydroxyacyl-ACP dehy

132 AcnA and other dehydratases do not show this trait.

133 The dehydratase domain FosDH1 from module 1 of the fostrieci

134 The recombinant dehydratase domain from NANS module 2, NANS DH2, was sho

135 as presented an enigma because the predicted dehydratase domain in module 7 is absent.

136 Unexpectedly, the structure reveals that the dehydratase domain of CylM resembles the catalytic core

137 a PKS mutant specifically inactivated in the dehydratase domain of extension-module 1 showed that thi

138 y ten conserved residues were mutated in the dehydratase domain of the best characterized family memb

139 h competes with dehydration catalyzed by the dehydratase domain.

140 The dehydratase domains (DHs) of the iso-migrastatin (iso-MG

141 plmT2 gene product, with no homology to PKS dehydratase domains, is required for efficient formation

142 ugh the sequential actions of dehydroquinate dehydratase (DQD) and shikimate dehydrogenase (SDH) cont

143 Dehydroshikimate dehydratases (DSDs) play a central role in this process,

144 SDH (L-serine dehydratase, EC 4.3.1.17) catalyzes the pyridoxal 5'-pho

145 The halogenase from CurA, and the dehydratases (ECH(1)s), decarboxylases (ECH(2)s) and eno

146 THIORIBOSE-1-PHOSPHATE-ISOMERASE1 (MTI1) and DEHYDRATASE-ENOLASE-PHOSPHATASE-COMPLEX1 (DEP1) under di

147 yl synthase, ketoacyl reductase, hydroxyacyl dehydratase, enoyl reductase and thioesterase enzyme gro

148 erium encodes a protein with 2-methylcitrate dehydratase enzyme activity.

149 tive site of type I dehydroquinase (DHQ1), a dehydratase enzyme that is a promising target for antivi

150 encoding an Fe/S-independent 2-methylcitrate dehydratase enzyme.

151 which encode for putative decarboxylase and dehydratase enzymes, respectively, afforded mutant strai

152 ies, together with 4a-OH-tetrahydrobiopterin dehydratase expression in the epidermis of untreated pat

153 A second dehydratase, FabZ, functions in acyl chain elongation bu

154 and an aspA sdaA mutant (also lacking serine dehydratase) failed to grow in complex media unless supp

155 andii aconitase A, a member of the monomeric dehydratase family of proteins that requires a [4Fe-4S]

156 Other enzymes in this iron-sulfur dehydratase family were similarly affected.

157 elonging to the new B12-independent glycerol dehydratase family, in contrast to S. enterica, which re

158 yze the enamine/imine intermediates that Thr dehydratase forms from Ser or Thr.

159 aracterization of a B12-independent glycerol dehydratase from Clostridium butyricum has recently been

160 ructural similarity to the GRE-type glycerol dehydratase from Clostridium butyricum, we demonstrate t

161 D-Glucarate dehydratase from Escherichia coli (GlucD), a member of t

162 The L-serine dehydratase from Legionella pneumophila (lpLSD) has rece

163 hydrolyzed the enamines/imines formed by Thr dehydratase from Ser or Thr and protected the Arabidopsi

164 ical and structural data for a GRE-type diol dehydratase from the organism Roseburia inulinivorans (R

165 ution crystal structure of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis in the rest

166 triking kinetic differences between L-serine dehydratases from Bacillus subtilis (bsLSD, type 1) and

167 rary of acid sugars to assign the L-fuconate dehydratase (FucD) function to a member of the mandelate

168 coding superoxide dismutase (sodA), fumarate dehydratase (fumC), bacterioferritin (bfr), bacterioferr

169 ng A0NXQ8 both (1) confirms its novel c3LHyp dehydratase function and (2) provides evidence for metab

170 talarate dehydratase (TalrD) and galactarate dehydratase (GalrD) functions to a group of orthologous

171 nctional assignment of Ob2843 as galactarate dehydratase (GalrD-II).

172 Both the glycerol dehydratase (GD) and the GD-activating enzyme (GD-AE) co

173 oupled to an increased abundance of the diol dehydratase gene cluster (pduCDE) in Firmicutes metageno

174 Ablation of the Arabidopsis dehydratase gene raised seedling levels of all NADHX for

175 olymorphism in the delta-aminolevulinic acid dehydratase gene, ALAD, were measured.

176 D-Glucarate dehydratase (GlucD) from Escherichia coli catalyzes the

177 rom soluble (aconitase B, 6-phosphogluconate dehydratase, glutamate synthase, fumarase A, and FNR) an

178 panosome de novo pathway enzymes GDP-mannose dehydratase (GMD) and GDP-fucose synthetase (GMER) were

179 which requires the action of GDP-mannose 4,6-dehydratase (GMD) and GDP-L-fucose synthase (FS), is con

180 Here we identify GDP-mannose 4,6-dehydratase (GMD) as a binding partner of tankyrase 1.

181 ential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epi

182 ential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epi

183 ha-1,6 linked fucosylation, GDP-mannose 4, 6-dehydratase (Gmds) and to a lesser extent fucosyltransfe

184 Arabidopsis (Arabidopsis thaliana) NAD(P)HX dehydratases (GRMZM5G840928, At5g19150) were able to rec

185 -regulated edd mutant (gluconate-6-phosphate dehydratase) had similar gluconate levels as the rpoN mu

186 tase, distinct from the beta-hydroxyacyl-ACP dehydratase HadABC complex, was constructed in the R mor

187 talyzed by dTDP-glucose 4,6-dehydratase (4,6-dehydratase) has been determined by rapid mix-chemical q

188 but to date only a small family of [4Fe-4S] dehydratases have been identified as direct targets.

189 ta gene encoding imidazoleglycerol-phosphate dehydratase (HIS3).

190 f either arogenate (ADT) or prephenate (PDT) dehydratases; however, neither enzyme(s) nor encoding ge

191 Imidazole glycerol-phosphate dehydratase (IGPD) catalyzes the sixth step of histidine

192 dehydration to 2-keto-3-deoxy-L-fuconate via dehydratase, (iii) 2-keto-3-deoxy-L-fuconate cleavage to

193 The threonine dehydratase IlvA is part of the isoleucine biosynthesis

194 phosphoribosyltransferase (TrpD), threonine dehydratase (IlvA), threonine, and phosphoribosyl pyroph

195 e pyridoxal 5'-phosphate-dependent threonine dehydratase (IlvA).

196 '-phosphate (PLP)-dependent serine/threonine dehydratases, IlvA and TdcB, as sources of endogenous 2-

197 ctivity measurements show that dihydroxyacid dehydratase (IlvD), an iron-sulphur enzyme essential for

198 ehydrogenase and Bacillus subtilis threonine dehydratase in a modified threonine-hyperproducing Esche

199 itively and independently; one is in fabZ, a dehydratase in fatty acid biosynthesis; the other is in

200 o 2-oxobutyrate (an alternative to threonine dehydratase in isoleucine biosynthesis) evolved several

201 The data indicate that dehydratase-independent pathways also function in establ

202 hat, indeed, has been converted from a sugar dehydratase into an aminotransferase.

203 tion in wbpM, which encodes a UDP-4,6-GlcNAc dehydratase involved in O-antigen synthesis.

204 We show here the in vitro activity of the dehydratase involved in the biosynthesis of the food pre

205 haracterization of the many lantibiotic-like dehydratases involved in the biosynthesis of other class

206 ved in diketopiperazine synthesis, LanB-like dehydratases involved in the posttranslational modificat

207 r anaerobic conditions, in part by oxidizing dehydratase iron-sulfur clusters.

208 microscopy shows that AdoCbl-dependent diol dehydratase is associated with these polyhedra.

209 nd the activity of the Fe-S enzyme gluconate dehydratase is diminished in the suf mutant during iron

210 isomerase potential of beta-hydroxyacyl-ACP dehydratases is determined by the properties of the beta

211 337, annotated as enolase or phosphopyruvate dehydratase, is associated with spirochete outer membran

212 PBGS, also called "delta-aminolevulinate dehydratase," is encoded by the ALAD gene and catalyzes

213 the three-dimensional structure of the MUR1 dehydratase isoform from Arabidopsis thaliana complexed

214 (UFA) biosynthesis is introduced by the FabA dehydratase/isomerase of the bacterial type II fatty aci

215 nthase I) and fabA (beta-hydroxydecanoyl-ACP dehydratase/isomerase) genes.

216 herefore E. faecalis FabZ1 is a bifunctional dehydratase/isomerase, an enzyme activity heretofore con

217 le, methylcitrate synthase and methylcitrate dehydratase, it does not appear to contain a distinct 2-

218 contained four enzymes: B(12)-dependent diol dehydratase, its putative reactivating factor, aldehyde

219 e, homoaconitase (Lys4p) and isopropylmalate dehydratase (Leu1p), respectively.

220 or NTF2 to be re-engineered into a scytalone dehydratase-like enzyme.

221 Knowledge of the distinct dehydratase-like enzymes Pen and Pal and their role in C

222 The 4,6-dehydratase makes use of tightly bound NAD(+) as the coe

223 The d-mannonate dehydratase (ManD) function was assigned to a group of o

224 ain amino acids, inhibition of dihydroxyacid dehydratase may have served to foster the role of NO in

225 thylcitrate synthase (MCS) and methylcitrate dehydratase (MCD) but not 2-methylisocitrate lyase (MCL)

226 ydride transfer step of the dTDP-glucose 4,6-dehydratase mechanism has been studied by mutagenesis an

227 e is formed through the action of this 3-DHS dehydratase metalloenzyme.

228 also known as coenzyme B(12))-dependent diol dehydratase model reactions of (i).

229 uloma formation in embryos infected with the dehydratase mutant was associated with a failure to repl

230 -phosphate cytidylyltransferase, CDP-Glc 4,6-dehydratase, NADH-dependent SAM:C-methyltransferase, and

231 he dehydration of Ser/Thr by the lantibiotic dehydratase NisB.

232 the nisA structural gene, cyclase (nisC) and dehydratase (nisB), together with an orthogonal nonsense

233 athway in plants comprising a stereospecific dehydratase (NNRD) and an epimerase (NNRE), the latter b

234 report that inactivation of the wbtA-encoded dehydratase of the O-antigen polysaccharide (O-PS) locus

235 epresents the first CDP nucleotide utilizing dehydratase of the short-chain dehydrogenase/reductase (

236 dent enzyme, GDP-4-keto-6-deoxy- d-mannose 3-dehydratase or ColD, catalyzes a dehydration reaction us

237 estigation is GDP-4-keto-6-deoxy-D-mannose 3-dehydratase or ColD, which catalyzes the removal of the

238 uding the non-PLP-dependent serine/threonine dehydratases or aconitases, the mechanisms of action of

239 dent enzyme, GDP-4-keto-6-deoxy- d-mannose-3-dehydratase (or ColD), was determined in our laboratory,

240 th the absence of a dedicated ketoreductase, dehydratase, or enoylreductase within the R1128 gene clu

241 molecules in the binding sites of scytalone dehydratase, p38-alphaMAP kinase, and EGFR kinase.

242 generated by an unusual, small and monomeric dehydratase, Pac13, which catalyses the dehydration of u

243 tant homology to pterin-4alpha-carbinolamine dehydratase (PCD) enzymes.

244 Pterin-4a-carbinolamine dehydratase (PCD) is a highly conserved enzyme that evol

245 factor 1 (DCoH)/pterin-4alpha-carbinolamine dehydratases (PCD)-like protein is the causative mutatio

246 Pterin-4a-carbinolamine dehydratases (PCDs) recycle oxidized pterin cofactors ge

247 stinct chorismate mutase (CM) and prephenate dehydratase (PDT) domains as well as a regulatory (R) do

248 ckaging of itself and other subunits of diol dehydratase (PduC and PduE) into the Pdu MCP.

249 packaging the coenzyme B(12)-dependent diol dehydratase (PduCDE) into the lumen of the Pdu MCP.

250 the recycling enzyme pterin 4a-carbinolamine dehydratase, PhhB, rescues tyrosine auxotrophy.

251 A specific prephenate dehydratase protein (PD1) was discovered to have a stron

252 ar methylases and nucleotide sugar epimerase-dehydratase proteins.

253 h we propose are not substrates for the 2-MC dehydratase (PrpD) enzyme, accumulate inside the cell, a

254 ch arogenate dehydratase (ADT) or prephenate dehydratase, respectively, plays a key role.

255 ia coli ACP and fatty acid 3-hydroxyacyl-ACP dehydratase, respectively.

256 ng the (3R)-hydroxyacyl-acyl carrier protein dehydratases resulted in more than a 16- and 80-fold inc

257 affected by the presence of serine/threonine dehydratases, revealing another mechanism of endogenous

258 The l-rhamnonate dehydratase (RhamD) function was assigned to a previousl

259 s thus undertaken to attempt to identify the dehydratase(s) involved in Phe formation in Arabidopsis,

260 ble of detecting the fungal enzyme scytalone dehydratase (SD) in bacteria, and demonstrated its sensi

261 Z (3-R-hydroxymyristoyl acyl carrier protein dehydratase), slrA (novel RpoE-regulated non-coding sRNA

262 ty acids, suggestive of an inhibition of the dehydratase step of the fatty-acid synthase type II elon

263 (SDR), belonging to the NDP-sugar epimerases/dehydratases subclass.

264 different from the one found in archetypical dehydratases such as aconitase, which use a serine resid

265 enolization capabilities of D135N and D135A dehydratases suggest an additional role for this residue

266 ichia coli dTDP-glucose 4,6-dehydratase (4,6-dehydratase) takes place in the active site in three ste

267 We assigned l-talarate dehydratase (TalrD) and galactarate dehydratase (GalrD)

268 cterized bifunctional l-talarate/galactarate dehydratase (TalrD/GalrD).

269 consistent with assignment of the d-tartrate dehydratase (TarD) function.

270 four DHs, identifying DH10 as the dedicated dehydratase that catalyzes the dehydration of the C17 hy

271 he tandem action of an ADP- or ATP-dependent dehydratase that converts (S)-NAD(P)HX to NAD(P)H and an

272 ing a yet to be identified plastid-localized dehydratase that converts tocopherolquinone to TMPBQ.

273 The first gene encodes a UDP-glucose-4,6-dehydratase that converts UDP-glucose to UDP-4-keto-6-de

274 a bifunctional chorismate mutase/prephenate dehydratase that is feedback inhibited by Phe, (b) PDT32

275 amine synthase, however, ColD functions as a dehydratase that removes the sugar C-3' hydroxyl group.

276 y utilize the same reductases and presumably dehydratase that the Elop proteins rely upon.

277 ising three elongases, two reductases, and a dehydratase that were localized to the endoplasmic retic

278 This enzyme belongs to a family of [4Fe-4S] dehydratases that are notoriously sensitive to univalent

279 Superoxide damages dehydratases that contain catalytic [4Fe-4S](2+) cluster

280 logy to be present in all bacterial L-serine dehydratases that utilize an Fe-S catalytic center.

281 mase, l-fuconate dehydratase, and d-tartrate dehydratase, the active site of TalrD/GalrD contains a g

282 he [4Fe-4S] cluster in E. coli dihydroxyacid dehydratase, the DinG [4Fe-4S] cluster is stable, and th

283 ated incorrectly as NAD-dependent epimerases/dehydratases; therefore, their prevalence in bacteria is

284 Although NO damaged the [Fe-S] clusters of dehydratases, this did not increase the amount of free i

285 use of site-directed mutations of scytalone dehydratase to study inhibitor binding interactions.

286 0NXQ7 ; 4HypE) and trans-3-hydroxy-l-proline dehydratase (UniProt ID A0NXQ9 ; t3LHypD).

287 on reaction mediated by the enzyme scytalone dehydratase was determined.

288 nd NAD(P)H to reaction mixtures in which 4,6-dehydratase WbpM had acted on the precursor substrate UD

289 in 81-176, we previously showed that the 4,6-dehydratase WcbK and the reductase WcaG generated GDP-6-

290 Entner-Doudoroff pathway 6-phosphogluconate dehydratase, were more susceptible to inactivation in yg

291 y to the elimination domain of lanthipeptide dehydratases, wherein insertions of secondary structural

292 th significant homology to a GDP-mannose 4,6-dehydratase, which catalyzes the first step in the biosy

293 e genes, desIV, codes for a dTDP-glucose 4,6-dehydratase, which is referred to as DesIV.

294 ially refined 3-dimensional structure of 4,6-dehydratase, which lacks substrate-nucleotide but contai

295 rther indicated that pterin-4a-carbinolamine dehydratase, which regenerates the AAH cofactor, is also

296 s of l-Fuc is catalyzed by GDP-d-mannose 4,6-dehydratase, which, in Arabidopsis, is encoded by the GM

297 yme, the GRE, is a dedicated 1,2-propanediol dehydratase with a new type of intramolecular encapsulat

298 al similarities between the enzyme scytalone dehydratase with nuclear transport factor 2 (NTF2) sugge

299 line-2-carboxylate (beta-elimination; c3LHyp dehydratase), with eventual total dehydration.

300 lobacter crescentus, native E. coli xylonate dehydratase (yjhG), a 2-keto acid decarboxylase from Pse