ライフサイエンスコーパス: dehydroalanine

1 that carries out the asymmetric reduction of dehydroalanine.

2 etathesis-reactive amino acid substrate, via dehydroalanine.

3 conjugate addition of sulfur nucleophiles to dehydroalanine.

4 lex natural products that contain C-terminal dehydroalanine.

5 eaction that converts cyanylated cysteine to dehydroalanine.

6 n of LarE converts its conserved Cys176 into dehydroalanine.

7 xylation, and the two previously unconfirmed dehydroalanines.

8 late-stage tail-to-tail condensation of two dehydroalanines.

9 s a formal [4 + 2] cycloaddition between two dehydroalanines, a unique transformation that had eluded

10 hioether with MSH results in regeneration of dehydroalanine, allowing a "functional switch" by subseq

11 of Michael addition of amines and thiols to dehydroalanine amides was greatly accelerated, leading t

12 s tested with a range of amines, thiols, and dehydroalanine amides.

13 oward intramolecular Michael addition to the dehydroalanine and dehydrobutyrine residues in the pepti

14 Nisin contains dehydroalanine and dehydrobutyrine residues that are for

15 clude dehydration of Ser and Thr residues to dehydroalanine and dehydrobutyrine, a transformation tha

16 at the side chain of Cys, converting it into dehydroalanine and generating a sulfur radical adduct at

17 ydration of Ser and Thr residues to generate dehydroalanines and dehydrobutyrines, followed by intram

18 idation of Met and Trp, conversion of Ser to dehydroalanine, and formylation of His) were observed in

19 py, for example, in cysteine modification to dehydroalanine, assessing labeling efficiency is difficu

20 ed dehydroalanine-containing systems undergo dehydroalanine cleavage under the same conditions, altho

21 t reaction/elimination methodology to afford dehydroalanines containing trans-cinnamic acid derivativ

22 s NMR spectrum suggested that sublancin is a dehydroalanine-containing lantibiotic.

23 robust method for the ribosomal synthesis of dehydroalanine-containing peptides.

24 Several simplified dehydroalanine-containing systems undergo dehydroalanine

25 are linked to an aminophosphonate analog of dehydroalanine, DeltaAla(P).

26 tion converts unstable S-nitrosocysteines to dehydroalanine derivatives under very mild conditions.

27 Thr residues in their peptide substrates to dehydroalanine (Dha) and dehydrobutyrine (Dhb), respecti

28 Old long-lived proteins contain dehydroalanine (Dha) and dehydrobutyrine (Dhb), two amin

29 action of N-nucleophiles with the amino acid dehydroalanine (Dha) in a protein context.

30 Dehydroalanine (Dha) is a nonproteinogenic electrophilic

31 By introduction of protein dehydroalanine (Dha) residues (in this instance, from a

32 via a formal [4+2] cycloaddition between two dehydroalanine (Dha) residues.

33 of glutathione to protein- or peptide-bound dehydroalanine (Dha) to form lanthionine, analogous to t

34 the lantibiotic signature structural motifs, dehydroalanine (Dha), dehydrobutyrine (Dhb), lanthionine

35 scribes the methodology for the synthesis of dehydroalanine (Dha)-containing peptides and illustrates

36 e-based strategies to generate the DUB probe dehydroalanine (Dha).

37 The Sep residue is then dephosphorylated to dehydroalanine (Dha).

38 me that generates the pyridine core from two dehydroalanines ejects the leader peptide as a C-termina

39 g lysine analogue, was recruited as a masked dehydroalanine equivalent.

40 + 2] cycloaddition when N-p-toluenesulfonyl-dehydroalanine ethyl ester is used as the coupling partn

41 we report the selective beta-sultam-induced dehydroalanine formation of the active site serine.

42 ntified both site-directed spin labeling and dehydroalanine formation.

43 robust oxidative elimination of cysteine to dehydroalanine has been discovered.

44 iately protected thiocarbohydrates to chiral dehydroalanines has been developed as a key step in the

45 Dehydroalanine is a nonproteinogenic amino acid, but it

46 iling experiments suggest the formation of a dehydroalanine moiety in living S. aureus cells upon bet

47 he synthesis of amino esters and amides from dehydroalanine monomers, a process which was found to oc

48 One dehydroalanine, one lanthionine and three beta-methyl-la

49 the acceptor site in thyroglobulin, leaving dehydroalanine or pyruvate at the donor position.

50 ible and irreversible (sulfinic acid; Cys to dehydroalanine) oxidations of GAPDH without exogenous su

51 tions were used to convert selenalysine into dehydroalanine post-translationally.

52 to be added to a common, readily accessible dehydroalanine precursor in a range of representative pr

53 oline H (8) using FmocNHCH(CH2SePh)CO2H as a dehydroalanine precursor that spontaneously eliminated b

54 lective functionalization of one subterminal dehydroalanine residue (Dha16) present in thiostrepton.

55 ndergoes C-O bond fission and formation of a dehydroalanine residue by elimination of the sulfonate a

56 olytic cleavage and the introduction of four dehydroalanine residues and two lanthionine bridges.

57 teines to thiazoles, and condensation of two dehydroalanine residues en route to the (tetrahydro)pyri

58 ve elimination of H2S2 to leave newly formed dehydroalanine residues in the peptide.

59 array of amino acids that also contains two dehydroalanine residues.

60 uence in the region between the newly formed dehydroalanine residues.

61 The bis-dehydroalanine tail equivalent 4 and the quinaldic acid

62 The dehydroalanine tail precursor 23 and the alanine equival

63 NpnJA reduces dehydroalanine to D-Ala using NAPDH as cosubstrate.

64 The identity of the dehydroalanine was confirmed by mass spectrometry and cr