ライフサイエンスコーパス: dehydroepiandrosterone

1 xysteroid sulfotransferase (SULT2A1) binding dehydroepiandrosterone.

2 = 0.34), androstenedione (+17.1%, P = 0.06), dehydroepiandrosterone (+14.4%, P = 0.02), and dehydroep

3 etic analogue of the chemopreventive hormone dehydroepiandrosterone, 16alpha-fluoro-5-androsten-17-on

4 Dehydroepiandrosterone (25 mg/kg/day) and/or prednisone

5 enyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-s

6 ast to this finding, an active metabolite of dehydroepiandrosterone, 7-oxo-dehydroepiandrosterone, do

7 r arginine and/or glutamine, with or without dehydroepiandrosterone, a natural endogenous steroid, co

8 he 17-hydroxypregnenolone initial product to dehydroepiandrosterone, a process representing the first

9 lowing the adrenal to secrete high levels of dehydroepiandrosterone, an androgen precursor.

10 Dehydroepiandrosterone and androstenediol (AED) have pre

11 onversion of the 17-hydroxylated steroids to dehydroepiandrosterone and androstenedione, respectively

12 There was a suggestion that dehydroepiandrosterone and dehydroepiandrosterone sulfat

13 uantitative determination of hydroxysteroids dehydroepiandrosterone and pregnenolone and their main m

14 Steroidal (progesterone, dehydroepiandrosterone) and non-steroidal antagonists (v

15 entrations of testosterone, androstenedione, dehydroepiandrosterone, and dehydroepiandrosterone sulfa

16 h using cyclosporine, mycophenolate mofetil, dehydroepiandrosterone, and intravenous immunoglobulin i

17 lucocorticoid antagonists, including RU-486, dehydroepiandrosterone, and progesterone.

18 anabolic-androgenic agents androstenedione, dehydroepiandrosterone, and the "parent" compound, testo

19 at/Km of the mutant is increased 6-fold with dehydroepiandrosterone as substrate.

20 termediate, yielding efficient production of dehydroepiandrosterone as the key intermediate in human

21 he prototypic hydroxysteroid SULT substrate, dehydroepiandrosterone, but both failed to catalyze the

22 eate the steroidogenic pathway upstream from dehydroepiandrosterone by documenting the presence of me

23 The pregnenolone, progesterone, and dehydroepiandrosterone content failed to change in rats

24 Whereas dehydroepiandrosterone conversion to DHT is usually very

25 Dehydroepiandrosterone (D) is biosynthesized in the brai

26 ernal standards, pregnenolone-d4 sulfate and dehydroepiandrosterone-d2 (DHEA), were used for quantita

27 one/testosterone), were significantly lower (dehydroepiandrosterone, Delta(4)-androstene-3,17-dione,

28 Dehydroepiandrosterone (DHEA) administration has been sh

29 The effects of dehydroepiandrosterone (DHEA) and 7-oxo-DHEA on the cell

30 ubsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro

31 y converted pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione, respe

32 progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respe

33 In contrast, the production of dehydroepiandrosterone (DHEA) and DHEA sulfate in the ad

34 ex steroid synthesis from adrenal precursors dehydroepiandrosterone (DHEA) and DHEA-sulfate has evolv

35 The adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) ha

36 Dehydroepiandrosterone (DHEA) and its sulfate derivative

37 ymorphisms of the STS gene and SULT2A1 gene, dehydroepiandrosterone (DHEA) and its sulfated form (DHE

38 Dehydroepiandrosterone (DHEA) and testosterone are widel

39 production of androgens, most significantly dehydroepiandrosterone (DHEA) and to a certain degree te

40 study was designed to assess the efficacy of dehydroepiandrosterone (DHEA) as a potential treatment.

41 oaded unimNPs with an endogenous S1R agonist dehydroepiandrosterone (DHEA) as an FDA-approved model d

42 s were conducted to evaluate the efficacy of dehydroepiandrosterone (DHEA) as an inhibitor of prostat

43 nd three women with INSR mutations underwent dehydroepiandrosterone (DHEA) challenge; serum androgens

44 S) concentrations by 88.2%, decreased plasma dehydroepiandrosterone (DHEA) concentrations by 84.6%, i

45 Age-related reductions in serum dehydroepiandrosterone (DHEA) concentrations may be invo

46 hypothesis that acute administration of oral dehydroepiandrosterone (DHEA) during episodes of repeate

47 The adrenal steroid dehydroepiandrosterone (DHEA) has antiglucocorticoid pro

48 The adrenal steroid dehydroepiandrosterone (DHEA) has been reported to act a

49 The adrenal steroid dehydroepiandrosterone (DHEA) has no known cellular rece

50 Pregnenolone (PREG) and dehydroepiandrosterone (DHEA) have been reported to impr

51 determine if the chemopreventive activity of dehydroepiandrosterone (DHEA) in the rat mammary gland c

52 ynthesis and release of the adrenal androgen dehydroepiandrosterone (DHEA) increases in response to s

53 Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid

54 Dehydroepiandrosterone (DHEA) is a neurosteroid with anx

55 Dehydroepiandrosterone (DHEA) is a neurosteroid with pot

56 Dehydroepiandrosterone (DHEA) is a peroxisome proliferat

57 The adrenal steroid hormone dehydroepiandrosterone (DHEA) is a potent inhibitor of m

58 Dehydroepiandrosterone (DHEA) is a ubiquitous adrenal ho

59 Dehydroepiandrosterone (DHEA) is a weak androgen also us

60 Dehydroepiandrosterone (DHEA) is an endogenous adrenal s

61 The adrenal androgen and neurosteroid dehydroepiandrosterone (DHEA) is available as over-the-c

62 liferative effects of the endogenous steroid dehydroepiandrosterone (DHEA) is not known.

63 Dehydroepiandrosterone (DHEA) is the most abundant circu

64 Dehydroepiandrosterone (DHEA) is the most abundant stero

65 kits were used to determine GCF cortisol and dehydroepiandrosterone (DHEA) levels.

66 t study examines the effect of administering dehydroepiandrosterone (DHEA) on short-term memory.

67 We have examined the effect of dehydroepiandrosterone (DHEA) on the development of EAE

68 This study examined the effect of exogenous dehydroepiandrosterone (DHEA) on the onset, incidence, a

69 article examines the effect of administering dehydroepiandrosterone (DHEA) on visual-spatial performa

70 Dehydroepiandrosterone (DHEA) regulates gene expression

71 To determine if dehydroepiandrosterone (DHEA) replacement improves insul

72 One indicator of this interest is that dehydroepiandrosterone (DHEA) supplements are widely con

73 By contrast, dehydroepiandrosterone (DHEA) suppressed VZ cell prolife

74 Dehydroepiandrosterone (DHEA), a 19-carbon precursor of

75 Dehydroepiandrosterone (DHEA), a C19 human adrenal stero

76 We apply this technology to release dehydroepiandrosterone (DHEA), a neurosteroid that promo

77 used in the prevention of osteoporosis, and dehydroepiandrosterone (DHEA), a ubiquitous steroid prec

78 to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortica

79 , is correlated with early morning cortisol, dehydroepiandrosterone (DHEA), and/or dehydroepiandroste

80 between mice receiving either vehicle alone, dehydroepiandrosterone (DHEA), or 2-difluoromethylornith

81 Administration of dehydroepiandrosterone (DHEA), or its sulfated form (DHE

82 nt with 5 mg/day testosterone (T), 75 mg/day dehydroepiandrosterone (DHEA), or placebo (P); and 57 el

83 Dehydroepiandrosterone (DHEA), the major steroid precurs

84 Dehydroepiandrosterone (DHEA), the predominant androgen

85 previous study showed that the neurosteroid dehydroepiandrosterone (DHEA), when administered preclin

86 The adrenal sex hormone dehydroepiandrosterone (DHEA), which is present in serum

87 erator, nafenopin, with those of the steroid dehydroepiandrosterone (DHEA).

88 t ability to sulfate hydroxysteroids such as dehydroepiandrosterone (DHEA).

89 ls of total testosterone, free testosterone, dehydroepiandrosterone (DHEAS), androstenedione, luteini

90 metabolite of dehydroepiandrosterone, 7-oxo-dehydroepiandrosterone, does not activate AR target gene

91 was found for the inhibitory actions of the dehydroepiandrosterone enantiomers.

92 (epinephrine, norepinephrine, cortisol, and dehydroepiandrosterone), immune activity (C-reactive pro

93 and can further metabolize steroids such as dehydroepiandrosterone into potent androgens, the de nov

94 The K(m) value of dehydroepiandrosterone is 13-fold greater, and the maxim

95 Dehydroepiandrosterone is the most abundant adrenal andr

96 Further evidence was presented showing that dehydroepiandrosterone, leflunomide, and methotrexate ar

97 tive protein and lower free testosterone and dehydroepiandrosterone levels.

98 Low-dose vaginal estrogen, lidocaine, and dehydroepiandrosterone may also be considered in some ca

99 Both arginine and glutamine as well as dehydroepiandrosterone may be useful therapeutic agents

100 rost-1,5-diene-17-ethylene ketal (ADEK) from dehydroepiandrosterone metabolites and derivatives as a

101 mary metabolic route for the modification of dehydroepiandrosterone neurosteroids in the brain.

102 of those pathways and a specific inhibitor (dehydroepiandrosterone) of glucose-6-phosphate dehydroge

103 In rats, pretreatment with either dehydroepiandrosterone or fluvoxamine, a high-affinity s

104 reactions on a single protein that converts dehydroepiandrosterone or pregnenolone to androstenedion

105 phate dehydrogenase (G6PD) by treatment with dehydroepiandrosterone or the antisense DNA oligomer of

106 ng G6PD activity using an inhibitor of G6PD (dehydroepiandrosterone) or by inhibiting G6PD expression

107 hydroxyindoleacetic acid, homovanillic acid, dehydroepiandrosterone, or pregnenolone.

108 In the formation of the male hormone dehydroepiandrosterone, pregnenolone is first hydroxylat

109 We previously showed that dehydroepiandrosterone protects against renal ischemia-r

110 infected PLSJL mice with the steroid hormone dehydroepiandrosterone reduced BBB permeability changes

111 Dehydroepiandrosterone-replacement therapy has been intr

112 d arginine plus glutamine and treatment with dehydroepiandrosterone reversed the susceptibility to in

113 eutical treatments include the mild androgen dehydroepiandrosterone, selective estrogen receptor modu

114 otransferase (EST), and a hydroxysteroid ST, dehydroepiandrosterone ST (DHEA-ST).

115 ancer cell lines showed only trace levels of dehydroepiandrosterone ST and hEST activities.

116 onoamine-sulfating forms of phenol ST (PST), dehydroepiandrosterone ST, and estrogen ST (hEST), were

117 We previously reported that dehydroepiandrosterone-stimulated phosphorylation of Fox

118 hydroepiandrosterone (+14.4%, P = 0.02), and dehydroepiandrosterone sulfate (+7.2%, P = 0.26) compare

119 The unnatural enantiomers of dehydroepiandrosterone sulfate (1), pregnenolone sulfate

120 in saliva and found significantly increased dehydroepiandrosterone sulfate (DHEA-S) and reduced estr

121 The adrenal steroid dehydroepiandrosterone sulfate (DHEA-S) has been shown i

122 body of research has provided evidence that dehydroepiandrosterone sulfate (DHEA-S) is involved in a

123 monstrate the utility of the nanosensor with dehydroepiandrosterone sulfate (DHEA-S), a small-molecul

124 easing hormone, adrenocorticotropic hormone, dehydroepiandrosterone sulfate (DHEA-S), and cortisol.

125 port that chronic exposure to high levels of dehydroepiandrosterone sulfate (DHEA-S; converted in viv

126 The effect of dehydroepiandrosterone sulfate (DHEAS) administered i.p.

127 tmenopausal serum levels of testosterone and dehydroepiandrosterone sulfate (DHEAS) and subsequent ri

128 adult male mice with the neuroactive steroid dehydroepiandrosterone sulfate (DHEAS) at 1 and 40 mg/kg

129 associations between obesity indicators and dehydroepiandrosterone sulfate (DHEAS) at 7 y of age and

130 (DU-14) to rats for 15 days increased plasma dehydroepiandrosterone sulfate (DHEAS) concentrations by

131 th PCOS have insulin resistance and elevated dehydroepiandrosterone sulfate (DHEAS) levels, which sup

132 (r > -0.6), bioavailable testosterone (BT), dehydroepiandrosterone sulfate (DHEAS), and the ratio of

133 ed inversely with plasma androstenedione and dehydroepiandrosterone sulfate (DHEAS), averaged across

134 terone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), luteinizing horm

135 neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate (DHEAS), pregnanolone, an

136 A receptor by another sulfated neurosteroid, dehydroepiandrosterone sulfate (DHEAS).

137 sterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS)], sex hormone bin

138 ine in serum testosterone, androsterone, and dehydroepiandrosterone sulfate (P < .05 for all).

139 that endogenous sex hormones (testosterone, dehydroepiandrosterone sulfate [DHEA-S], and estradiol)

140 PREGS potentiation of mEPSCs was mimicked by dehydroepiandrosterone sulfate and (+)-pentazocine but n

141 ational study found lower, but still normal, dehydroepiandrosterone sulfate concentrations in statin-

142 Dehydroepiandrosterone sulfate had a borderline associat

143 We examined testosterone, estradiol, and dehydroepiandrosterone sulfate in relation to incident A

144 served enantioselectivity for the actions of dehydroepiandrosterone sulfate indicates that its inhibi

145 , via administration of the enzyme substrate dehydroepiandrosterone sulfate or the enzyme inhibitor C

146 androstenedione, dehydroepiandrosterone, and dehydroepiandrosterone sulfate were associated with risk

147 a suggestion that dehydroepiandrosterone and dehydroepiandrosterone sulfate were inversely associated

148 androgens testosterone, androstenedione, and dehydroepiandrosterone sulfate were negatively associate

149 impact of SLCO2B1 expression level on DHEAS (dehydroepiandrosterone sulfate) uptake was evaluated in

150 baseline SA (testosterone, androstenedione, dehydroepiandrosterone sulfate), was measured by ultrase

151 ports taurocholic acid, the adrenal androgen dehydroepiandrosterone sulfate, and thyroid hormone, as

152 physical activity, social class, education, dehydroepiandrosterone sulfate, androstanediol glucuroni

153 terol, high-density lipoprotein cholesterol, dehydroepiandrosterone sulfate, cortisol, systolic and d

154 rone sulfate, androstenedione, testosterone, dehydroepiandrosterone sulfate, follicle-stimulating hor

155 s of estrone, estradiol, testosterone, SHBG, dehydroepiandrosterone sulfate, free estradiol, and free

156 +CD38+HLA-DR+, and CD8+CD38+HLA-DR+ T cells, dehydroepiandrosterone sulfate, free testosterone, homeo

157 re found for endogenous estrogens, cortisol, dehydroepiandrosterone sulfate, insulin, glucagon, or fo

158 lerosis and increasing quartiles of estrone, dehydroepiandrosterone sulfate, or androstenedione.

159 a,17beta-diol disulfate 2, P = 0.000064; and dehydroepiandrosterone sulfate, P = 0.00011).

160 iol, estrone, estrone sulfate, testosterone, dehydroepiandrosterone sulfate, prolactin, and sex hormo

161 tic levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, sex hormone-binding glob

162 ten-3beta,17beta-diol disulfate 1 and 2, and dehydroepiandrosterone sulfate, were the next most stron

163 on of ERK1 and ERK2; however, the steroid PP dehydroepiandrosterone sulfate, which does not induce im

164 , but not by phenobarbital or the steroid PP dehydroepiandrosterone sulfate.

165 licle-stimulating hormone, testosterone, and dehydroepiandrosterone sulfate.

166 itor oxythiamine (OT) and the G6PD inhibitor dehydroepiandrosterone-sulfate (0.5 microM each) exerted

167 tisol, dehydroepiandrosterone (DHEA), and/or dehydroepiandrosterone-sulfate (DHEA-S) concentrations.

168 udy to determine whether hormone levels (E2, dehydroepiandrosterone-sulfate [DHEA-S], and testosteron

169 In vivo testing of 400 mg/kg OT or dehydroepiandrosterone-sulfate in C57BL/6 mice hosting E

170 Dehydroepiandrosterone-sulfate, a unique PP in being a s

171 activation via sulfonation of the hormone by dehydroepiandrosterone sulfotransferase (DST), an androg

172 Dehydroepiandrosterone sulfotransferase (Std) catalyzes

173 Dehydroepiandrosterone sulfotransferase (STD) is a hydro

174 xpression of the phase II conjugating enzyme dehydroepiandrosterone sulfotransferase (STD) known to s

175 Dehydroepiandrosterone sulfotransferase (SULT2A1) is a c

176 phenol sulfotransferases, HAST1, -3, and -4, dehydroepiandrosterone sulfotransferase, and estrogen su

177 nfluence steroid/xenobiotic metabolism using dehydroepiandrosterone sulfotransferase.

178 Evidence is accruing in support of dehydroepiandrosterone supplementation in adrenal insuff

179 o-conjugation of endogenous hydroxysteroids (dehydroepiandrosterone, testosterone, bile acids), and d

180 ollowed by a 17,20-lyase reaction to produce dehydroepiandrosterone, the key intermediate in human sy

181 n the other hand, neither isoform sulfonates dehydroepiandrosterone to any significant degree.

182 in conversion of the adrenal-derived steroid dehydroepiandrosterone to DHT.

183 and oxidizes cholesterol, pregnenolone, and dehydroepiandrosterone to their respective 3-keto-4-ene

184 The enzyme shows no substrate preference for dehydroepiandrosterone versus pregnenolone with second-o

185 Preflight dehydroepiandrosterone was positively associated with co

186 Dehydroepiandrosterone was reduced in the cachectic pati

187 Among 22 derivatives/metabolites of dehydroepiandrosterone, we found 4 steroids [no. 4, 1,3,

188 limits of androsterone, epiandrosterone, and dehydroepiandrosterone were 1-2 orders of magnitude grea

189 ficient subjects, plasma androstenedione and dehydroepiandrosterone were in a range similar to that o

190 f both 1 alpha, 25-dihydroxy vitamin D 3 and dehydroepiandrosterone were used together as hormonal im

191 regnanolone, pregnenolone, testosterone, and dehydroepiandrosterone) were isolated from the plasma or

192 Trilostane is a competitive inhibitor of dehydroepiandrosterone with a Ki of 197 +/- 8 microM.