ライフサイエンスコーパス: deiminase

1 Protein arginine deiminase 2 (PAD2) plays a key role in the onset and pro

2 Peptidyl arginine deiminase 2 (PAD2), an enzyme that converts protein argi

3 Peptidylarginine deiminase 2 (PAD2/PADI2) has been implicated in various

4 nced gene expression of the peptidylarginine deiminase 2 gene, itself a chromatin-modifying protein.

5 expression and activity of peptidylarginine deiminase 2, one of the five enzymes responsible for cit

6 Peptidyl arginine deiminase-2 and cyclic nucleotide phosphodiesterase are

7 ain of LRP1 is a target of peptidyl arginine deiminase-2-mediated deimination in vitro.

8 dotoxic mice with YW3-56, a peptidylarginine deiminase-2/4 inhibitor, significantly diminished levels

9 d in the three genes PADI3 (peptidylarginine deiminase 3), TGM3 (transglutaminase 3), and TCHH (trich

10 ied citrullination sites in protein arginine deiminase 4 (12 sites) and in fibrinogen (25 sites, two

11 ulline with recombinant polypeptide arginine deiminase 4 (PAD4) abolished ADAMDEC1-catalyzed pro-EGF1

12 n NET formation, including peptidyl arginine deiminase 4 (PAD4) activity, neutrophil nuclear histone

13 ination of core histones by peptidylarginine deiminase 4 (PAD4) and that patients with autoimmune dis

14 citrullination catalyzed by peptidylarginine deiminase 4 (PAD4) correlates with chromatin decondensat

15 sumed role of an overactive protein arginine deiminase 4 (PAD4) in the pathophysiology of rheumatoid

16 Protein arginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme that cat

17 Peptidylarginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme that con

18 Protein arginine deiminase 4 (PAD4) is a transcriptional coregulator that

19 Peptidylarginine deiminase 4 (PAD4) is an enzyme that citrullinates histo

20 rullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo.

21 trullination and NETosis by peptidylarginine deiminase 4 (PAD4) on MI/R.

22 , we demonstrate that human peptidylarginine deiminase 4 (PAD4) regulates histone Arg methylation by

23 t of specific inhibitors of protein-arginine deiminase 4 (PAD4), an enzyme required for NET formation

24 [NETosis]), orchestrated by peptidylarginine deiminase 4 (PAD4), damages organs in acute inflammatory

25 Peptidyl arginine deiminase 4 (PAD4), which binds proteins and citrullinat

26 hils express high levels of peptidylarginine deiminase 4 (PAD4), which catalyzes histone citrullinati

27 analyzed venous thrombi in peptidylarginine deiminase 4 (PAD4)-deficient mice that cannot citrullina

28 Expression of peptidylarginine deiminase 4 (PAD4, encoded by Padi4 in mice), an enzyme

29 Peptidylarginine deiminase 4 (PAD4/PADI4) counteracts the functions of pr

30 functional haplotype of the peptidylarginine deiminase 4 gene (PADI4) has recently been identified as

31 Here, we report that peptidylarginine deiminase 4, a histone citrullination enzyme, is involve

32 Peptidylarginine deiminase 4, an enzyme that mediates chromatin decondens

33 enzyme initiating NETosis, peptidylarginine deiminase 4, and activates the NOD-like receptor family,

34 tion mark of p300 GBD is removed by peptidyl deiminase 4, thereby enhancing the p300-GRIP1 interactio

35 Neutrophils from peptidylarginine deiminase 4-(PAD4(-/-)) deficient mice, which lack the e

36 r trap formation involving peptidyl arginine deiminase 4.

37 histone citrullination by peptidyl arginine deiminase-4 (PADI4) in contact to particulate agents to

38 s via DNase infusion, or in peptidylarginine deiminase-4-deficient mice (which have impaired NET prod

39 e nuclear DNA catalyzed by peptidyl arginine deiminase-4.

40 Arginine deiminase accelerates substrate hydrolysis 6 x 10(12)-fo

41 termined that strain 1457 devoid of arginine deiminase activity (1457 DeltaADI) was significantly les

42 ant Manfredo strains for the enzyme arginine deiminase (AD) showed that significant activity was pres

43 L-arginine deiminase (ADI) catalyzes the hydrolysis of L-arginine t

44 Arginine deiminase (ADI) catalyzes the hydrolytic conversion of L

45 L-arginine deiminase (ADI) catalyzes the irreversible hydrolysis of

46 l-Arginine deiminase (ADI) catalyzes the irreversible hydrolysis of

47 o evaluate the effects of pegylated arginine deiminase (ADI) in terms of toxicity, tumor response, al

48 Arginine deiminase (ADI) inhibits growth in various ASS-deficient

49 on the use of recombinant bacterial arginine deiminase (ADI) isolated from the cells of a recombinant

50 rcA2) to assess the function of the arginine deiminase (ADI) pathway in organic acid resistance and b

51 of the amino acid arginine via the arginine deiminase (ADI) pathway supplements energy production an

52 le to therapeutic intervention with arginine deiminase (ADI), an enzyme responsible for consuming the

53 rginine deprivation using pegylated arginine deiminase (ADI-PEG 20) against primary AMLs in a xenogra

54 Purpose Pegylated arginine deiminase (ADI-PEG 20) depletes essential amino acid lev

55 arginine-degrading enzyme pegylated arginine deiminase (ADI-PEG 20).

56 arginine deprivation with pegylated arginine deiminase (ADI-PEG20) as a therapeutic.

57 e arginine-lowering agent pegylated arginine deiminase (ADI-PEG20) has not been evaluated in a random

58 The development of pegylated arginine deiminase (ADI-PEG20) has renewed interest in arginine d

59 ding recombinant protein, pegylated arginine deiminase (ADI-PEG20), has been in clinical trials for t

60 o arginine depletion with pegylated arginine deiminase (ADI-PEG20).

61 Arginine deiminase (ADI; EC 3.5.3.6.), an arginine-degrading enzy

62 ying enzymes (GMEs) consists of the agmatine deiminases (AgDs).

63 u2ABCA' that contains two genes for agmatine deiminases (agu2A and agu2A').

64 ing ornithine carbamoyltransferase, arginine deiminase, alpha-enolase, and alpha- and beta-giardins,

65 transcript levels of genes encoding arginine deiminase and a putative serine dehydratase.

66 Arginase, arginine deiminase and arginine decarboxylase are potential enzym

67 se 2 randomized clinical trial, the Arginine Deiminase and Mesothelioma (ADAM) study, was conducted b

68 s of polyamine biosynthetic enzymes agmatine deiminase and N-carbamoylputrescine amidohydrolase in ar

69 e anr gene (anaerobic regulation of arginine deiminase and nitrate reduction) that controls anaerobic

70 or acetaldehyde dehydrogenase ExaC, arginine deiminase ArcA, and glyceraldehyde 3-phosphate dehydroge

71 s and P. gingivalis, and identified arginine deiminase (ArcA) of S. cristatus as the signaling molecu

72 erived from Streptococcus cristatus arginine deiminase (ArcA) was able to repress the expression and

73 ent mutants were constructed within arginine deiminase (arcA1 and arcA2) to assess the function of th

74 wo coupled recognition modules, a creatinine deiminase (CD) enzyme and a 2-nitrophenol (2NPh) titrati

75 protein cross-linking) and peptidyl-arginine deiminase (conversion of arginines to citrullines with l

76 sed as transducer and immobilized creatinine deiminase (EC 3.5.4.21)--as a biosensitive element.

77 he citrulline formed by the peptidylarginine deiminase enzyme modification functions to unfold protei

78 y (t(1/2)=4.8h) whereas a bacterial arginine deiminase evaluated in phase II clinical trials was repo

79 activity correlates with levels of arginine deiminase expression in S. cristatus.

80 The peptidylarginine deiminase family member PAD4 (also called PADI4) is mark

81 ial kinetic characterization of the agmatine deiminase from Helicobacter pylori and described the syn

82 L-Arginine deiminase from Pseudomonas aeruginosa (PaADI) catalyzes

83 film assays of mutants of all three agmatine deiminase genes in PA14 revealed that deletion of agu2AB

84 Peptidyl arginine deiminases have been shown to be hyperactive in neurodeg

85 biofilm growth and the function of arginine deiminase in USA300 clones led us to genetically inactiv

86 Peptidylarginine deiminase inhibition blocked NET formation, reduced athe

87 Peptidylarginine deiminase inhibition is a strategy that can decrease in

88 injections of Cl-amidine, a peptidylarginine deiminase inhibitor.

89 tion network and identified peptidylarginine deiminases, kallikreins, serine proteinase inhibitor fam

90 for egg and embryo-abundant peptidylarginine deiminase-like protein.

91 n be solubilized following peptidyl-arginine deiminase modification.

92 lly inactivate the sole copy of the arginine deiminase operon by deleting the arginine/ornithine anti

93 n P. aeruginosa GMSF enzymes PaADI, agmatine deiminase (PaAgDI), and N(omega),N(omega)-dimethylargini

94 on of H3R26 is catalyzed by peptidylarginine deiminase (PAD) 2 and not by PAD4 (which citrullinates H

95 Peptidyl arginine deiminase (PAD) catalyzes the post-translational citrull

96 d was PAD3, a member of the peptidylarginine deiminase (PAD) enzyme family that converts protein argi

97 al to the calcium-dependent peptidylarginine deiminase (PAD) enzyme family.

98 protein or influencing the peptidylarginine deiminase (PAD) enzymes found in the monocyte/macrophage

99 he citrulline amino acid by protein arginine deiminase (PAD) family members.

100 the first purification of a peptidylarginine deiminase (PAD) from a prokaryote.

101 ly found that Cl-amidine, a peptidylarginine deiminase (PAD) inhibitor, improves survival in a mouse

102 vivo, LL-37 is exposed to peptidyl arginine deiminase (PAD), an enzyme released by inflammatory cell

103 spectrometric sequencing of peptidylarginine deiminase (PAD)-modified protein.

104 o histone citrullination by protein arginine deiminase (PAD)4, exocytosis of chromatin and enzymes as

105 se (DDAH); EC 3.5.3.18] and peptidylarginine deiminase (PAD; EC 3.5.3.15) catalyze hydrolysis of subs

106 Cl-amidine, an inhibitor of peptidylarginine deiminases (PAD), to block NET formation and were evalua

107 arginine, are generated by peptidyl arginine deiminases (PAD).

108 arginine to citrulline by peptidyl arginine deiminase (PAD4), change protein structure and function.

109 Peptidylarginine deiminase (PADI) enzymes are increasingly being associat

110 c vertebrate enzymes called peptidylarginine deiminases (PADIs) and is associated with the developmen

111 The protein arginine deiminases (PADs) are a family of enzymes that catalyze

112 Peptidylarginine deiminases (PADs) are enzymes that convert arginine to c

113 Protein arginine deiminases (PADs) catalyze the hydrolysis of peptidyl ar

114 Protein arginine deiminases (PADs) catalyze the post-translational hydrol

115 rains lacking the bacterial peptidylarginine deiminases (PADs) or gingipains were created to assess t

116 ated via the actions of the protein arginine deiminases (PADs), are known to develop in the murine co

117 he reaction is catalyzed by peptidylarginine deiminases (PADs), which are found in vertebrates but no

118 group of enzymes called the protein arginine deiminases (PADs).

119 ATL included those involved in the arginine deiminase pathway and a total of 140 carbohydrate transp

120 ile genetic element that encodes an arginine deiminase pathway and an oligopeptide permease system th

121 e in the expression of genes in the arginine deiminase pathway during stringent response activation.

122 ginine catabolism by enzymes of the arginine deiminase pathway, encoded by the arcDABC operon.

123 ed to be unrelated to ArcD from the arginine deiminase pathway.

124 of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) can influence citrullination of protein

125 One of these is peptidylarginine deiminase (PPAD), an enzyme unique to P. gingivalis amon

126 Padi family, encoding the peptidyl arginine deiminases responsible for citrulline protein modificati

127 metabolism by oral bacteria via the arginine deiminase system (ADS) increases the local pH, which can

128 The arginine deiminase system (ADS) is associated with arginine catab

129 The arginine deiminase system (ADS) is responsible for the production

130 The arginine deiminase system (ADS) of S. gordonii enables cells to p

131 occus mutans expresses a functional agmatine deiminase system (AgDS) encoded by the agmatine-inducibl

132 An operon encoding enzymes of the agmatine deiminase system (AgDS) has been identified in the cario

133 Induction of the agmatine deiminase system (AgDS) of Streptococcus mutans requires

134 that the constitutive ACME-encoded arginine-deiminase system (Arc) allows USA300 to thrive in acidic

135 sion and anaerobic induction of the arginine deiminase system.

136 and the deiminating enzymes peptidylarginine deiminase type 2 (PAD-2) and PAD-4.

137 he citrullinating enzymes, peptidyl arginine deiminase type 4 (PAD-4), is genetically associated with

138 citrullinated proteins and peptidylarginine deiminase type 4 (PAD-4).

139 plets is first modified by peptidyl-arginine deiminase which denatures it and makes it more soluble.

140 termed PPAD (Porphyromonas peptidylarginine deiminase), which is genetically unrelated to eukaryotic

141 Peptidylarginine deiminases, which are commonly found in mammalian cells,