ライフサイエンスコーパス: deiodinase

1 d retain intrathyroidal iodine (iodotyrosine deiodinase).

2 late identified the gene responsible for the deiodinase.

3 PPARgamma, PPARalpha, PGC-1alpha, and type 2 deiodinase.

4 levels of Pgc-1alpha, Pparalpha, and type 2 deiodinase.

5 family, type 1 (D1; 8 h) or type 2 (D2; 2 h) deiodinase.

6 he short-lived, membrane-bound enzyme type 2 deiodinase.

7 sed endocytosis of the type II iodothyronine deiodinase.

8 atalytically active type II iodothyronine 5'-deiodinase.

9 w that targeting SMRT/N-CoR complexes to the deiodinase 1 gene (D1) requires at least two interaction

10 tional 3' UTR of another selenoprotein mRNA, deiodinase 1.

11 the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activates TH, were h

12 amma (PPARgamma), and increased hypothalamic deiodinase 2 expression.

13 nd expression of deiodinases 2 and 3 (mainly deiodinase 2) in whole skin biopsy specimens, and in the

14 We also found expression of deiodinases 2 and 3 (mainly deiodinase 2) in whole skin

15 d elevation in deiodinase-3 and reduction in deiodinase-2 decreases TH signaling that can be worsened

16 We found that deiodinase-2 levels were reduced, whereas deiodinase-3 l

17 els of TH are regulated by deiodinases, with deiodinase-2 mediating TH activation and deiodinase-3 TH

18 l structure of the catalytic domain of mouse deiodinase 3 (Dio3), which reveals a close structural si

19 n infants with IVH the combined elevation in deiodinase-3 and reduction in deiodinase-2 decreases TH

20 at deiodinase-2 levels were reduced, whereas deiodinase-3 levels were increased in brain samples of b

21 ith deiodinase-2 mediating TH activation and deiodinase-3 TH inactivation.

22 ecreased activity of type I iodothyronine 5'-deiodinase (5' D-I), the hepatic enzyme that converts th

23 regulates levels of type II iodothyronine 5'-deiodinase (5'D-II) by modulating enzyme inactivation an

24 es protection from thyroid hormone by type 3 deiodinase, a thyroid hormone-inactivating enzyme.

25 The deiodinases activate or inactivate thyroid hormone, and

26 ecreased brain TH content as well as altered deiodinase activities and TH target gene expression.

27 ding vitamin A/E and metabolites and hepatic deiodinase activity (DI).

28 Brain deiodinase activity (T4-ORD) was reduced by approximatel

29 astrocytes lacking type II iodothyronine 5'-deiodinase activity and examined the effects of cAMP on

30 analogue dramatically suppresses its native deiodinase activity and leads to significant nitroreduct

31 ells, TBMEHP inhibited rat hepatic microsome deiodinase activity and was an agonist for PPARs in muri

32 The resulting protein retained deiodinase activity and was purified using anion exchang

33 These transgenic tadpoles had high levels of deiodinase activity and were resistant to exogenous TH a

34 ycytes and that DARPP-32 may modulate type 2 deiodinase activity by regulating the phosphorylation st

35 Since type 2 deiodinase activity can be induced by substances that in

36 explain the heterogeneous response of type 2 deiodinase activity in these two loci in response to spe

37 l CMZ cells can be induced to proliferate if deiodinase activity is inhibited.

38 In this paper, the deiodinase activity of a series of peri-substituted naph

39 ndent activation of type II iodothyronine 5'-deiodinase activity results from the synthesis of additi

40 NA was present in tissues showing type II 5'-deiodinase activity such as brain and cAMP-stimulated as

41 ls in the peri-positions exhibit much higher deiodinase activity than those having two thiols or a th

42 In vitro, TBMEHP inhibited deiodinase activity, induced adipocyte differentiation i

43 thyroid gland activity and increased hepatic deiodinase activity.

44 of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signa

45 Type 2 iodothyronine deiodinase, an enzyme involved in the conversion of thyr

46 12F1, respectively, and code for the type 3 deiodinase, an enzyme that inactivates thyroid hormones

47 tial subunit of rat type II iodothyronine 5'-deiodinase and 2) identify the first non-selenocysteine

48 , GPX3, and GPX4), one or more iodothyronine deiodinases and two thioredixin reductases.

49 H signaling via changes in the expression of deiodinases and/or TRs, and normalization of TH signalin

50 Deiodinases apparently evolved from the ubiquitous Prx s

51 sition and the physical nature of the active deiodinase are unknown.

52 The iodothyronine deiodinases are a family of oxidoreductases that catalyz

53 The deiodinases are a family of selenoproteins expressed in

54 Deiodinases are at the interface between the beta-cateni

55 Types 1 and 3 iodothyronine deiodinases are known to be selenocysteine-containing en

56 Deiodinases are selenocysteine-dependent membrane protei

57 A three-dimensional model of the deiodinase based on the coordinates of the minor nitrore

58 hosphoenolpyruvate carboxykinase, and type I deiodinase but not hydroxymethylglutaryl-CoA reductase,

59 nase), as well as the diet-responsive type I deiodinase, but not those involved in mitochondrial resp

60 DARPP-32 may regulate the activity of type 2 deiodinase by prolonging the activation of CREB.

61 ated following the discovery that the type 2 deiodinase can be an important component in both the Hed

62 Type II iodothyronine 5'-deiodinase catalyzes the bioactivation of thyroid hormon

63 redox-active cysteines or the iodothyronine deiodinases containing an active site selenocysteine.

64 signaling in colorectal CSCs (CR-CSC), where deiodinases control cell division and chemosensitivity.

65 Of particular interest in the type I deiodinase (D1) is Cys124, which is vicinal to the selen

66 Surprisingly, while type 1 deiodinase (D1) is known to be present in human thyroid,

67 Type I deiodinase (D1) is the best characterized family member

68 The other activating deiodinase, D1, or a truncated D2 molecule (Delta18-D2)

69 Type II deiodinase (D2) activates thyroid hormone by converting

70 persistent increase in type 2 iodothyronine deiodinase (D2) activity in the mediobasal hypothalamus

71 Type 2 5'-deiodinase (D2) activity rose dramatically in the mouse

72 atalyzed by the enzyme type II iodothyronine deiodinase (D2) and the local effect (cell autonomy) of

73 Type 2 deiodinase (D2) catalyzes the 5'-deiodination of thyroxi

74 Type 2 deiodinase (D2) converts the prohormone thyroxine (T4) t

75 The enzyme type II iodothyronine deiodinase (D2) converts thyroxine (T4) to the active ho

76 though a putative human type 2 iodothyronine deiodinase (D2) gene (hDio2) encoding a similar selenopr

77 Type 2 iodothyronine deiodinase (D2) is a recently cloned selenodeiodinase th

78 Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the re

79 The type 2 iodothyronine deiodinase (D2) is an integral membrane ER-resident sele

80 The type 2 iodothyronine deiodinase (D2) is critical for the intracellular produc

81 m resident thyroid hormone-activating type 2 deiodinase (D2) is inactivated by ubiquitination via the

82 (BAT), thyroid hormone activation via type 2 deiodinase (D2) is necessary for adaptive thermogenesis,

83 re is a transient surge in hepatocyte type 2 deiodinase (D2) that activates the prohormone thyroxine

84 The Dio2 gene encodes the type 2 deiodinase (D2) that activates thyroxine (T4) to 3,3',5-

85 tem is the thyroid hormone-activating type 2 deiodinase (D2), an endoplasmic reticulum-resident type

86 The mouse cochlea expresses type 2 deiodinase (D2), an enzyme that converts thyroxine, the

87 AMP-responsive gene for type 2 iodothyronine deiodinase (D2), an intracellular enzyme that activates

88 The expression of type 2 deiodinase (D2), which activates thyroid hormone in skel

89 Skeletal myocytes express the type 2 deiodinase (D2), which generates 3,5,3'-triiodothyronine

90 in the inactivation of type 2 iodothyronine deiodinase (D2).

91 ne MGC: 19375; (B). Type II iodothyronine 5'-deiodinase (D2); (C). reduced expression 3 gene; (D). la

92 ed locally by T4 deiodination via the type 2 deiodinase (D2); this pathway is self-limited by ubiquit

93 the blood are stable, but the action of the deiodinases (D2-D3) provides cell-specific regulation of

94 In neurons, the type 3 deiodinase (D3) inactivates thyroid hormone and reduces

95 TH-inactivating) enzyme type 3 iodothyronine deiodinase (D3) is an oncofetal protein that is rarely e

96 opus laevis metamorphosis encodes a type III deiodinase (D3) that inactivates TH.

97 show that dorsal CMZ cells express type III deiodinase (D3), an enzyme that inactivates TH.

98 Type 3 deiodinase (D3), the selenoenzyme that inactivates thyro

99 Type 3 iodothyronine deiodinase (D3), the thyroid hormone-inactivating enzyme

100 mely high levels of the type 3 iodothyronine deiodinase (D3), which inactivates thyroxine and 3,3', 5

101 rinatal exposure of tissues to THs is type 3 deiodinase (D3).

102 increasingly clear with the availability of deiodinase-deficient animals.

103 mentary DNAs (cDNAs) for the types I and III deiodinases (DI and DIII, respectively) have been isolat

104 The type II deiodinase (DII) converts thyroxine to the active hormon

105 ressions of crystallin genes increased; T4/3-deiodinase DIII (DIO3) increased 10-fold; and sodium-pot

106 Direct visualization of the deiodinase dimer showed that the holoenzyme was sorted t

107 cyclohexane (beta-TBECH), on thyroid hormone deiodinase (DIO) and sulfotransferase (SULT) activity we

108 spatiotemporal expression of thyroid hormone deiodinase (dio) genes.

109 ilability by regulating the expression of TH deiodinases (DIO).

110 Decreased activity of type I 5'-deiodinase (DIO1), which converts T4 to T3, contributes

111 ating hormone beta subunit (tshb) and type 2 deiodinase (dio2) are coexpressed in zebrafish thyrotrop

112 ormed molecular scanning of the human type 2 deiodinase (DIO2) gene and evaluated a novel variant for

113 y reduced expression of type 2 iodothyronine deiodinase (Dio2), a gene that is required for T4-mediat

114 hyroid hormone induced bZip protein (thibz), deiodinases (dio2, dio3), thyroid receptors (tralpha, tr

115 on of the proximal promoter for the type III deiodinase (dio3) gene in the hamster hypothalamus is re

116 ts, express high levels of a T3-inactivating deiodinase, Dio3.

117 ation complexes at the TR target gene type I deiodinase (DioI) together with RNA polymerase II (Pol I

118 Deiodinases (DIOs) are selenoproteins involved in thyroi

119 d drug treatment and targeting iodothyronine deiodinases (DIOs) to suppress cellular tri-iodothyronin

120 Type 3 deiodinase, encoded by Dio3, is expressed in the immatur

121 hyroid hormone availability is controlled by deiodinase enzymes (DIO2 and DIO3) expressed in tanycyte

122 is at the active center of the iodothyronine deiodinase enzymes that catalyze the conversion of the p

123 In addition, deiodinase enzymes that regulate levels of the main acti

124 lation of supply of triiodothyronine (T3) by deiodinase enzymes.

125 f IMC-H7 on hypothalamic expression of these deiodinase enzymes.

126 of activating and inactivating iodothyronine deiodinase enzymes.

127 non-selenocysteine containing subunit of the deiodinase family of enzymes.

128 athione peroxidase family of enzymes, the 5' deiodinases, formate dehydrogenases, glycine reductase,

129 ng of the 29-kDa subunit (p29) of type II 5'-deiodinase from a lambdazapII cDNA library prepared from

130 Deregulation of deiodinase function and thyroid hormone status has been

131 omolog 1 gene and the type III iodothyronine deiodinase gene (Dlk1-Dio3) is located on distal mouse c

132 ts from the GPX1 and type I iodothyronine 5'-deiodinase genes in RNA electrophoretic mobility shift a

133 Additionally, the deiodinase has been discovered to act as a debrominase a

134 g, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in

135 and Cys194, which has been conserved in all deiodinases identified to date.

136 Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that catal

137 omodulin, collagen types II/X downregulated, deiodinase II and netrin-1 upregulated.

138 in the thyroid hormone-inactivating enzyme, deiodinase-III (Dio3) and insulin-like growth factor 2 (

139 imprinted thyroid hormone-inactivating gene deiodinase-III (Dio3) is responsible.

140 tamorphic changes, suggesting a role for the deiodinase in modulating the influence of TH on these ti

141 of thyroxine to triiodothyronine via type 2 deiodinase in mouse skeletal muscle and in a cell model

142 hese data suggest that the native type II 5'-deiodinase in rat brain is unrelated to this artificial

143 s thyroid hormone (TH) receptor isoforms and deiodinases in an age-dependent pattern as glucose respo

144 PT to control expression of thyroid hormone deiodinases in ependymal cells (tanycytes) of the fetal

145 The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination

146 We also assessed TBMEHP for deiodinase inhibition using rat liver microsomes and for

147 The deiodinase inhibitor iopanoic acid blocks T4- but not T3

148 rom fish transferred to SW plus or minus the deiodinase inhibitor, iopanoic acid, revealed SW-induced

149 The cellular TH level is mainly regulated by deiodinase iodothyronine (DIO)-2 and -3.

150 ly regulated DLK1-DIO3 (delta-like 1 homolog-deiodinase, iodothyronine 3) cluster on human chromosome

151 Type I iodothyronine deiodinase is a approximately 50-kDa, integral membrane

152 Iodotyrosine deiodinase is a member of the same structural superfamil

153 Type II iodothyronine 5'-deiodinase is an approximately 200-kDa multimeric enzyme

154 Iodotyrosine deiodinase is essential for iodide homeostasis and prope

155 However, the deiodinase is not structurally related to other known fl

156 Type I deiodinase is the best characterized member of a small f

157 Expression of the type III deiodinase is up-regulated in growing tissues nearing co

158 The flavoprotein iodotyrosine deiodinase (IYD) is responsible for iodide salvage by re

159 The flavoprotein iodotyrosine deiodinase (IYD) salvages iodide from mono- and diiodoty

160 thyroxine modulates type II iodothyronine 5'-deiodinase levels by initiating the binding of the endos

161 The results suggest that type 3 deiodinase limits hormonal exposure of the cone to level

162 Targeting iodothyronine deiodinases locally in the retina is a therapeutic strat

163 velopmental expression patterns suggest that deiodinases may control the concentration of active thyr

164 age, and 2) the identification of peripheral deiodinase-mediated T4-to-T3 conversion provided a physi

165 tochemical studies were performed for type 2 deiodinase mRNA and DARPP-32 immunoreactivity (IR), or D

166 Both type 2 deiodinase mRNA and DARPP-32-IR also extended into tanyc

167 gene nor lovastatin treatment reduced type I deiodinase mRNA levels.

168 Type 2 deiodinase mRNA was found in the cell bodies of all DARP

169 pot 14, Bcl-3, glucose 6-phosphatase, and 5'-deiodinase mRNA was higher in transgenic mice than litte

170 In contrast, type 2 deiodinase mRNA was not present in the same cells that c

171 e relative mRNA expression of genes encoding deiodinases, nuclear thyroid receptors, and membrane tra

172 T4 metabolism is regulated by the deiodinases of which type 2 is expressed in humans in sk

173 We identified two type 2 deiodinase paralogs, dio2a and dio2b, responsible for co

174 ible role for personalized medicine based on deiodinase polymorphisms.

175 of translation or degradation of the type I deiodinase protein.

176 n genes encoding type I and II iodothyronine deiodinases, respectively.

177 l fat a robust induction occurred for type 2 deiodinase, sarcoendoplasmic reticulum Ca2+-ATPase, mito

178 Extensive deiodinase studies indicated that T1AM was derived from

179 The amino acid sequence of the deiodinase suggests the presence of three domains.

180 A similar decrease in type I deiodinase synthesis was observed when transfected cells

181 ane receptor (integrin), four proteinases, a deiodinase that degrades thyroid hormone, and a protein

182 catenin reduced D3 levels and induced type 2 deiodinase (the D3 antagonist that converts 3,5,3',5' te

183 ith the Shh-mediated reduction of the type 2 deiodinase, the thyroxine-activating enzyme, and both ef

184 The deiodinases thus appear to play an important role in reg

185 ne (TH) receptor or a type-III iodothyronine deiodinase transgene in the nervous system have reduced

186 eroid receptor superfamily), a TH-converting deiodinase, two metabolic enzymes, a protein disulfide i

187 2 and beta1, with regional colocalization of deiodinase type 2 (D2) mRNA in the developing forebrain,

188 iodide symporter, and deiodinase type 2, and deiodinase type 2 enzyme activity.

189 hyroperoxidase, sodium iodide symporter, and deiodinase type 2, and deiodinase type 2 enzyme activity

190 Deiodinase type 3 (D3) mRNA expression was confined to t

191 Thyroid hormone (TH) metabolism, mediated by deiodinase types 1, 2, and 3 (D1, D2, and D3) is profoun

192 iodide salvage in the thyroid, iodotyrosine deiodinase, was solubilized from porcine thyroid microso

193 unctions of Se-dependent enzymes, such as TH deiodinases, which convert thyroxine (T4) to the physiol

194 y, we investigated the role of iodothyronine deiodinases, which in target tissues convert the prohorm

195 rain, cellular levels of TH are regulated by deiodinases, with deiodinase-2 mediating TH activation a