ライフサイエンスコーパス: delete

1 ls in which PARP1 and/or PARP2, or PARP3 are deleted.

2 hose engineered, are mutated, amplified, and deleted.

3 copic positive and were classified as pfhrp2-deleted.

4 which was NSCLC with responsive EGFR exon 19 deleted.

5 a major viral transforming protein, LMP1, is deleted.

6 ally formed when the C-terminal residues are deleted.

7 , two or all three of the endonucleases were deleted.

8 le into small apoptotic bodies when DFNA5 is deleted.

9 nts in which distinct functional domains are deleted.

10 h hIL-12 receptor subunits were functionally deleted.

11 ed after the nuclear localization signal was deleted.

12 enzyme that promotes H3K9 demethylation, is deleted.

13 artificial chromosome in which the G1MDR was deleted.

14 tions are enriched in cells in which Mbd4 is deleted.

15 Remarkably, deleting 303 nucleotides of the promoter including all k

16 Purpose Most anemic patients with non-deleted 5q lower-risk myelodysplastic syndromes (MDS) ar

17 In this work, analysis of minimal commonly deleted 8p segments to identify candidate TSG implicated

18 We randomly delete a number of reactions from a metabolic network an

19 Here, we identified and deleted a polyketide synthase (PKS) gene PfmaE and showe

20 ng a PDGFRbeta promoter-driven Cre system to delete alphav integrins in activated fibroblasts identif

21 dual short guide RNA approach to effectively delete an important coding region of Sav1, which increas

22 efit in patients with newly diagnosed non-co-deleted anaplastic glioma.

23 hemotherapy in newly diagnosed 1p/19q non-co-deleted anaplastic gliomas, which are associated with lo

24 adjuvant temozolomide in adults with non-co-deleted anaplastic gliomas.

25 elements (CopyCat elements) can efficiently delete and replace the L2-CRM with orthologous sequences

26 Non-chromosome 6q genes are also frequently deleted and include LYN, a regulator of B-cell receptor

27 main models by adjusting DC-score threshold, deleting and adding domain linkers, and assembling domai

28 The NKG2C (KLRC2) gene is frequently deleted, and copy number influences the adaptive respons

29 To enhance attenuation of ASFV-G, we deleted another gene, UK (DP96R), which was previously s

30 We have used mouse transgenics to delete Apc and/or Apc2 from mouse mammary epithelium to

31 another BRCT-domain protein, MDC1, in BRIT1-deleted B cells increases the severity of CSR defect ove

32 When this PUL was deleted, B. ovatus was no longer able to grow on locust

33 and granulosa cells was blocked when Wt1 was deleted before sex determination and most genital ridge

34 mp2 signaling in the liver, we conditionally deleted Bmp2 in LSECs using EC subtype-specific Stab2-Cr

35 In contrast, deleting Bmpr1a in early osteoblasts with 3.6 Col 1-Cre

36 fy signaling processes downstream of PKA, we deleted both PKA catalytic subunits using CRISPR-Cas9, f

37 anase in 1,6-beta-glucan depolymerization by deleting bt3312, which prevented the growth of B. thetai

38 AIT cells isolated from HBV patients are not deleted but are more activated, which can be normalized

39 enriching regulatory B lymphocytes that are deleted by anti-CD20 cotherapy.

40 two different mouse models in which Tsc1 is deleted by Cre expression in oligodendrocyte progenitor

41 ill help to reliably track and conditionally delete C3aR expression in experimental models of inflamm

42 ill help to reliably track and conditionally delete C5aR2 expression in experimental models of inflam

43 We conditionally deleted canonical NF-kappaB members p65 and c-Rel in dev

44 We deleted Capzb specifically in hair cells using Atoh1-Cre

45 identified cel-mir-237 as a miRNA which when deleted caused animals to be more resistant to IR, where

46 re-Loxp transgenic technology to selectively delete CB1Rs in VgluT2-expressing glutamatergic neurons

47 sion was noted in both wildtype and Ppp1r15a deleted cells and in cells rendered ISR-deficient by CRI

48 The IP6K1 deleted cells display substantial decreases of stress fi

49 Consistently, alm1-deleted cells show increased levels of KT proteins, incl

50 /Gr-1(-) cells remained viable in Runx1/Cbfb-deleted cells, indicating that suppressing RUNX activity

51 for pVHL recognition, is interrupted in IPMK-deleted cells.

52 rylation is substantially decreased in IP6K1 deleted cells.

53 totic activity of caspase-2 is necessary for deleting cells with mitotic aberrations to limit aneuplo

54 When both the SMuSh and the CWI pathways are deleted, cells fail to adapt to compressive stress, and

55 Pkm2-deleted CGNPs showed reduced lactate production and incr

56 red expression of genes located in amplified/deleted chromosomal regions.

57 tivities, and the mobilization of internally deleted copies in the IR/DR subgroup, including Sleeping

58 A single, heavily deleted copy of this retrovirus has been found in the ge

59 nto a human DLBCL cell line using CRISPR and deleted Crebbp and Ep300 in the GC B cell compartment of

60 Deleting CXCR3 in leukocytes significantly reduced leuko

61 CRISPR/Cas9 was used to delete defined rhomboid enhancers mediating expression a

62 short palindromic repeats)-Cas9 targeting to delete DNA regions corresponding to nine chemokine 3'-UT

63 ve analysed the consequences of individually deleting each of the genes of the mce4 operon of M. smeg

64 Deleting EBNA2 sites significantly reduced their target

65 However, we recently showed that an LMP1-deleted EBV mutant induces B cell lymphomas in a newly d

66 hat the method correctly predicts 68% of the deleted edges on average.

67 binding stability and specificity to 19 exon deleted EGFR mutation in vitro and vivo.

68 nomic intron recombination signal sequence k-deleting element coding joint, genomic Vdelta1-Jdelta1,

69 cles, intron recombination signal sequence k-deleting element signal joints on Igkappa-deleting recom

70 -dependent genetic recombination strategy to delete ENaC function after terminal field maturation occ

71 More specifically, deleting ENaCs during development prevented the normal m

72 is the only gene in this locus that has been deleted entirely in cases involving the smallest microde

73 ssed the role of EphA2 in atherosclerosis by deleting EphA2 in a mouse model of atherosclerosis (Apoe

74 xon skipping or large genomic deletions that delete exons.

75 Deleting FBW7 in FBW7-wild-type CRC cells abolishes Mcl-

76 on these findings, we examined the impact of deleting FGFBP1 on NMJs.

77 Deleting Fgfr1/2/3 abolished kainic acid-induced bSC den

78 Deleting Fgfr1/2/3 in bSCs had minimal impact on dendrit

79 A expression of Fgfrs and their ligands Fgfs Deleting Fgfr1/2/3 not only impaired bSC dendritogenesis

80 Cells deleted for fin are defective for spore formation and ex

81 of a previously described vaccine candidate deleted for ORF56 and ORF57 (Delta56-57).

82 In contrast, in cells deleted for the pre-crRNA processing gene cas6, where on

83 e used homologous recombination to precisely delete foraging, generating the for(0) null allele, and

84 Interestingly, a deleted form of Epac1 in its mitochondrial-targeting seq

85 ategies rely on the expression of internally deleted forms of dystrophin, missing important functiona

86 Conversely, deleting FoxO3 in mice results in fewer numbers of autop

87 ons between three linkage groups flanked the deleted fragments, which, according to segregation analy

88 nhibit sIPSCs in POMC neurons when MORs were deleted from AgRP neurons, and activation of the inhibit

89 Mice, which have ADAM10 deleted from DCs, have dramatic reductions in IgE produc

90 This increase is also seen when ADAM10 is deleted from human B cell lines.

91 Mice in which JAK2 had been deleted from podocytes exhibited an elevation in urine a

92 plexes after protein complex components were deleted from the genome.

93 pressor chaperone Grp78 can be conditionally deleted from the intestinal epithelium.

94 during virus replication in cells and can be deleted from the virus genome without reducing virus rep

95 ion (XCI) in early embryos, is conditionally deleted from Xi in somatic cells (Xi(Xist)).

96 either activated FV nor recombinant B-domain-deleted FV could enhance TFPI-mediated inhibition of FXa

97 Deleting gamma2-AMPK led to increases in pre-rRNA level,

98 Moreover, bacteria with a deleted gene encoding SPIN showed decreased survival com

99 ating genetic interactions (GIs) from CRISPR-deleted gene pairs.

100 chia coli deletion mutants and revealed that deleting genes for respiratory chain flavoproteins or fo

101 r GR is required for adipogenesis in vivo By deleting GR in precursors of brown adipocytes, we found

102 Patients with 1p/19q non-co-deleted had higher extent of activation on SSC (P < 0.02

103 copy of the syntenic 16p11.2 region has been deleted have revealed morphological, behavioral, and ele

104 nockout mice with Mb1-Cre knockin animals to delete Hdac3 in early progenitor B cells.

105 Here, we used Pkhd1/Cre mice to delete HNF-1beta specifically in renal collecting ducts

106 Sin3B-deleted HSCs accumulate and fail to properly differentia

107 serotype 5 (AAV5) vector encoding a B-domain-deleted human factor VIII (AAV5-hFVIII-SQ) in nine men w

108 b or the retroviral drug atazanavir, the Por-deleted humanized PIRF mice develop higher levels of the

109 ependent expression cassette inserted into a deleted ICP4 locus remained almost silent.

110 2CRE-mediated recombination to conditionally delete Id1 against global Id3 ablation (Id cDKOs), which

111 t not IDH1 wild type, gliomas systematically deleted IDH1 in vitro and in vivo, further suggestive of

112 Deleting IgSF21 in mice impairs inhibitory presynaptic o

113 Here we delete in a moss the P450 oxygenase that defines the ent

114 We used the CRISPR/Cas9 technique to delete in mice the syntenic region on chromosome 8 to cr

115 KLF6 is heterozygously deleted in 74.5% of the analyzed glioblastomas and predi

116 lls from PMF patients, and the NOL3 locus is deleted in a subset of patients with myeloid malignancie

117 We find that when Mbd4 exons 6 to 8 are deleted in a switching B cell line, DSB formation is sev

118 CreER) mice, in which Runx2 was specifically deleted in Aggrecan-expressing chondrocytes by administe

119 Somatic copy number of 8 genes frequently deleted in ALL (CDKN2A, ETV6, IKZF1, PAX5, RB1, BTG1, PA

120 ind that a cellular mRNA-specific regulator, Deleted in Azoospermia-like (Dazl), also employs the PAB

121 rrow, Spi1 (encoding PU.1) was conditionally deleted in B cells by Cre recombinase under control of t

122 The MAIT cells were not deleted in blood or liver of cHBV patients compared with

123 binding of NAD(+) to the NHD domain of DBC1 (deleted in breast cancer 1) prevents it from inhibiting

124 ce, in which the Atp7a gene was specifically deleted in cells of the myeloid lineage, including macro

125 Extracellular netrin-1 and its receptor deleted in colorectal cancer (DCC) promote axon branchin

126 de evidence that in humans, Netrin receptor, Deleted in Colorectal Cancer (DCC), is a master regulato

127 n of the Netrin-1 guidance cue receptor DCC (deleted in colorectal cancer) appear to confer resilienc

128 he gene encoding the axon-guidance receptor 'deleted in colorectal carcinoma' (DCC), which has been i

129 t (cKO) mice in which Ndufs4 was selectively deleted in dopaminergic neurons (Ndufs4 cKO).

130 ably, this was not observed when Cacna1c was deleted in glutamatergic neurons during adulthood, where

131 1stm/stm mice in which Sco1 was specifically deleted in heart and striated muscle, respectively.

132 Nf1, all of which are frequently mutated or deleted in HGSC.

133 of the genome that is frequently mutated or deleted in human cancer.

134 cally inhibited or when the DNA-PKcs gene is deleted in human cells.

135 of rapamycin complex 1 (mTORC1), was acutely deleted in intestinal epithelium via Tamoxifen injection

136 differentiation, is among genes hemizygously deleted in Jacobsen syndrome, resulting in a macrothromb

137 lated by the asymmetrically localized RhoGAP Deleted in liver cancer (DLC1) in the cytoplasm at the c

138 catenin was activated at different levels or deleted in mice at the late stage of fracture healing, a

139 L6 and other genes that lead to obesity when deleted in mice, do contribute to obesity.

140 i, most notably SMAD4, which is homozygously deleted in nearly one-third of cases.

141 mouse in which the L-VGCC isoform Cav1.2 was deleted in NG2-positive OPCs (Cav1.2(KO)).

142 hich the gene encoding the GR is selectively deleted in NKp46(+) innate lymphoid cells (ILCs), we dem

143 00 Saccharomyces cerevisiae selected strains deleted in nuclear genes revealed that cells lacking the

144 t tumors with lung metastasis; however, mice deleted in p38delta (PyMT/p38delta(-/-)) exhibited delay

145 nalysis revealed that SERPINB2 is frequently deleted in PDAC.

146 When SoxC genes are deleted in postmitotic RGCs, contralateral RGC axons gro

147 3p13-14, spanning FOXP1 to SHQ1, is commonly deleted in prostate cancer and lost broadly in a range o

148 ssential' genes: those that are occasionally deleted in some cancers but are almost always retained i

149 epithelial sodium channel was conditionally deleted in taste buds (alphaENaC knockout).

150 We generated mice in which Kir4.1 could be deleted in the kidney after the mice are fully developed

151 mbinant H9N2 viruses with amino acids (38KQ) deleted in the NA stalk, and changing the amino acid at

152 naptic cell-adhesion molecules neurexins or 'deleted-in-colorectal-cancer', and the postsynaptic glut

153 we discovered that 29 bacterial genes, when deleted, increase longevity in the host Caenorhabditis e

154 ctive SMA modifier in five asymptomatic SMN1-deleted individuals carrying only four SMN2 copies.

155 , with 1.1 megabases of the synthetic genome deleted, inserted, or altered.

156 insulin mimetope (InsB9-23 R22E) efficiently deletes insulin-specific T cells and prevents escape of

157 The 80 amino acid IL3 deleted isoform hH3R365 is more permissive in its signal

158 and behavioral effects of 2-AG deficiency by deleting its primary synthetic enzyme, diacylglycerol li

159 lox) mice with Gdf9-Cre mice to specifically delete Kat8 in oocytes.

160 We used CRISPR-Cas9 technology to delete key DNA repair genes in human colon organoids, fo

161 Bim-deleted kidney macrophages exhibit a novel transcription

162 Here we deleted KIF1Bbeta in the mouse sympathetic nervous syste

163 omic DNA encoding the VH and CH1 domains was deleted, leading to the production of a camel-like LAIR1

164 s a stem cell regulator in glioma which when deleted leads to increased stemness, tumorigenicity and

165 sity lipoprotein receptor (Ldlr), which when deleted, leads to severe hypercholesterolemia and athero

166 tective role of live attenuated centrin gene-deleted Leishmania donovani (LdCen(-/-) ) parasites thro

167 tenuated Leishmania vaccines such as centrin deleted Leishmania donovani parasites (LdCen (-/-)) show

168 pombe gene deletion collection, we identify deleted loci that make cells sensitive to formamide.

169 ecombination in mice that inherit an already deleted LoxP allele in trans A similar phenomenon has pr

170 poptotic targets Noxa and Puma seen in Hdac8-deleted LT-HSCs.

171 hepatocytes, and when the murine Por gene is deleted (<5%), they predominantly use human cytochrome m

172 of microarray data using wild-type and c-Jun-deleted macrophages highlight the central function of c-

173 hich both the receptor and its signaling are deleted, making it impossible to explore the possible si

174 Wild-type MC38 cells outcompeted PD-L1-deleted MC38 cells in vivo, demonstrating tumor PD-L1 co

175 Deleting mcrA in a genetic dereplication strain has allo

176 Notably, adult FOXA2-deleted mice are completely infertile because of defects

177 e with stress stimulation, whereas Bex1 gene-deleted mice are protected from heart failure-promoting

178 Conversely, gene-deleted mice lacking both Mg29 and MLP protein showed a

179 pregnancy failed by day 10 in neonatal FOXA2-deleted mice lacking uterine glands.

180 glands, whereas the uteri of neonatal FOXA2-deleted mice were completely aglandular.

181 The uteri of adult FOXA2-deleted mice were morphologically normal and contained g

182 term in uterine gland-containing adult FOXA2-deleted mice, pregnancy failed by day 10 in neonatal FOX

183 Conversely, Par4-deleted mice, which had reduced circulating microparticl

184 ata in wild-type, Gm-csf- and eotaxin-1-gene-deleted mice, while eosinophils are recruited but do not

185 ressed during early pregnancy in adult FOXA2-deleted mice.

186 Our data show that caspase-2 is required for deleting mitotically aberrant cells.

187 rotease-activated receptor-1), in Runx1/Cbfb-deleted MLL-AF9 cells.

188 the effects of reduced mitochondrial NADP by deleting MNADK in mice.

189 In mice, deleting monocarboxylate transporter-1 (MCT1) from tumor

190 ted chromosome loss strategy to individually delete mouse chromosomes 9, 10, 12, or 14 in tetraploid

191 ore autophagic cell death in Bax/Bak1 double-deleted mouse embryonic fibroblasts.

192 Deleting MSK1/2 also inhibits the development of carrage

193 Deleting mutant SOD1 expression selectively in brainstem

194 study, we report that ZNF750 is exclusively deleted, mutated and underexpressed in human SCCs, and l

195 This was supported by analysis of deleted/mutated 5'UTRs and two native regulatory single-

196 Cbl, Notch1 and Mll2, which are recurrently deleted/mutated in human haematological malignancies.

197 arge and mutually compatible sets of epitope-deleting mutations and produced highly active but aggres

198 Deleting MYC ESEs greatly reduced MYC expression and LCL

199 Although BRG1-deleted myoblasts that ectopically express the SA-Brg1 m

200 role in repression by the unliganded TR, we deleted NCoR1 in the livers of euthyroid and hypothyroid

201 Slices containing Pten-deleted neurons showed increased recruitment of neurons

202 tly, these changes were not confined to Pten-deleted neurons, but involved the entire network, sugges

203 We find that deleting Nhx1 disrupts the fusogenicity of the MVB, not

204 To test this hypothesis, we conditionally deleted Numb on a Numbl mutant background just prior to

205 VACV deleted of the Zalpha domain of E3 (VACV-E3LDelta83N) in

206 s of LKB1 and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) induces activation of th

207 fecting the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) loss regulated protein k

208 r suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), alters the invasive pot

209 Conditionally deleting one copy of FGF receptor 2 (FGFR2) in adult mou

210 of p38alpha, and mice in which p38alpha was deleted only in CD11c-expressing cells, we surprisingly

211 Using an in vivo system in which ADAM10 is deleted only on B cells, elevated levels of ICOSL were s

212 other tumor suppressors that are frequently deleted or acquire loss-of-function mutations, the major

213 cytes with autoreactive potential are either deleted or differentiated into regulatory T cells (Tregs

214 earrangement patients reveals that HYDIN2 is deleted or duplicated in most cases.

215 mbinant viruses from which the VNDT motif is deleted or in which the N-linked glycosylation site is m

216 PTEN and TP53 are two of the most commonly deleted or mutated genes in prostate cancer, the compoun

217 ding maintained mitotic spindle formation as deleting or mutating TOG5 compromised spindle architectu

218 Deleting ORF7 did not affect viral entry, viral genome r

219 ering that the methodologies we have used to delete Oxtr do not rule out targeting the neighboring CA

220 Pfhrp2-deleted P. falciparum is a common cause of RDT-/PCR+ mal

221 Spread of pfhrp2-deleted P. falciparum mutants, resistant to detection by

222 differentiation between wild-type and pfhrp2-deleted parasite populations (GST = .046, p </= .00001).

223 We identified 149 pfhrp2-deleted parasites, representing 6.4% of all P. falciparu

224 T-led diagnosis to drive selection of pfhrp2-deleted parasites.

225 g-adverse reaction edges were systematically deleted per fold showed that the method correctly predic

226 We therefore deleted PGRN specifically in microglia and found that it

227 re, we utilized PLCgamma1-specific shRNAs to delete PLCgamma1 in OC precursors derived from wild type

228 tant was active, as were mutants obtained by deleting positions on either side of Gly-457.

229 PCBP2, as well as viral protein 3CD(pro), to deleted positive-strand RNAs corresponding to the 5' end

230 fted proinflammatory macrophage phenotype by deleting PPARgamma in myeloid cells and found a 5- to 10

231 generalization, as animals with genetically deleted presynaptic GABAB(1a) receptors cannot discrimin

232 for "periplasmic transaminase A" An in-frame-deleted ptaA mutant selectively lacked the alpha-ketoglu

233 Glycoprotein-deleted rabies virus-mediated monosynaptic tracing has b

234 orithms on their ability to both predict the deleted reactions from a universal set and to fill gaps.

235 k-deleting element signal joints on Igkappa-deleting recombination excision circles, genomic intron

236 Deleted regions are enriched for long DNA repeats and th

237 both kinesin-5 Cut7 and kinesin-14 Pkl1 are deleted, restoring spindle bipolarity.

238 drogenase, encoded by Clo1313_0076, was also deleted resulting in decreased total xylitol production

239 chronic necroptosis on immune homeostasis by deleting Ripk1 in mouse dendritic cells.

240 Th17 and Treg cell biology, we specifically deleted S1P1 in Th17 and Treg cells using IL-17A (Cre) a

241 Although deleting Sac3 residues 1-90 produced a wild-type phenoty

242 Eight microscopically-confirmed pfhrp2-deleted samples with intact pfhrp3 locus were positive b

243 Thymic dendritic cells (DC) delete self-antigen-specific thymocytes, and drive devel

244 tion precludes secondary rearrangements that delete self-reactive VJ rearranged genes.

245 In contrast, internally deleted sequences (MITEs) are preferred substrates of ma

246 -targets, and scores the conservation of the deleted sequences rapidly.

247 sis expressing either wild-type DeltaspAvr2 (deleted signal-peptide) or the DeltaspAvr2(R45H) variant

248 veral questions regarding Tfp biology by (i) deleting single or mutiple genes, (ii) altering specific

249 in the intrinsic pathway of apoptosis, were deleted specifically from kidney proximal tubules and us

250 Here, we genetically deleted Srebf-2 from hepatocytes and confirmed that SREB

251 Creating an Area II-deleted state within already specified Neurog3-expressin

252 gic release component is diminished in SynII-deleted (SynII(-)) slices.

253 Abs can elicit a number of mechanisms to delete target cells, including complement-dependent cyto

254 with two existing models that conditionally delete Tcf4 Our data identify a set of overlapping pheno

255 activation of HSP1; looping is lost in tail-deleted TFAM.

256 Importantly, IRES mutations that delete the bulge impair viral translation and completely

257 We have leveraged this technology to delete the coding sequences for a known type III effecto

258 To abrogate PRC2 function, we delete the core PRC2 protein EED in F1 hybrid trophoblas

259 we used CrispR-Cas9-mediated gene editing to delete the gene encoding for AC, ASAH1, in human A375 me

260 tain differentiated cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice.

261 Here we delete the Kctd13 gene in mice and demonstrate reduced s

262 Attempts to delete the NCgl2760 orthologue in Mycobacterium smegmati

263 We used CRISPR/Cas9 to delete the orthologous region in zebrafish in order to t

264 A conditional Mapk14 allele was used to delete the p38alpha encoding gene specifically in cardia

265 in the CUP1 array; recombination events that delete the URA3 insertion from the CUP1 array occur at a

266 We deleted the crp/cya genes in SLT12 (pCZ1) and SLT16 (pCZ

267 erentiation of sensory receptors in vivo, we deleted the entire gene cluster in mouse germline throug

268 netic elements required for Pxr function, we deleted the entire pxr gene from a developmentally defec

269 Here, we conditionally deleted the MHC-II beta-chain from myelinating Schwann c

270 Here we specifically deleted the PDK1 gene in the hematopoietic system and fo

271 s-CRISPR/Cas9 strategy was very efficient in deleting the approximately 23 kb of intervening genomic

272 Finally, we find that deleting the C-terminal extension of Lmod1 and Lmod2 res

273 Deleting the commissural projections of V0s results in l

274 Mutating the catalytic cysteine (C1036A) or deleting the entire HECT domain (amino acids 758-1068) r

275 e and gene expression closely mimic those of deleting the fetal globin repressor BCL11A, implicating

276 Moreover, we found that deleting the large, class-specific insert in the microtu

277 al-regulated kinases 1 and 2, or blocking or deleting the mitogen- and stress-activated kinases 1 and

278 Furthermore, deleting the PDZ motif did not inhibit the G-1-stimulate

279 use gustatory system showed that selectively deleting the primary transduction channel for sodium tas

280 Deleting the Prkca gene, which encodes PKCalpha, reverse

281 r differentiating PrrF and PrrH functions by deleting the PrrHIG sequence [prrF(DeltaHIG)].

282 In contrast, deleting the residues before the single hydrophobic segm

283 ion of labor among mycobacterial RNases H by deleting the rnhA, rnhB, rnhC and rnhD genes, individual

284 promoter to eliminate the RNA Pol II PIC by deleting the TATA-box resulted in loss of transcription,

285 a new strain of iNKT cell-deficient mice by deleting the Traj18 locus using CRISPR/Cas9 technology,

286 ally, one NYVAC-C-KC vector was generated by deleting the viral gene B19R, an inhibitor of the type I

287 When either the CR or TMD domain was deleted, the mutated proteins localized to the stereocil

288 tion (human R580W, mouse R579W) and one that deletes three pathogenic arginines, and explored phenoty

289 runcated variant (where residues 189-207 are deleted to mimic a site of cleavage within RRM2 found in

290 hich the EC expressed TRPM2 is conditionally deleted (Trpm2(iDeltaEC) ).

291 motherapy and worse prognosis than 1p/19q co-deleted tumours, is unclear.

292 Using CRISPR/Cas9, we deleted two host factors, basigin (BSG) and CD44, for wh

293 re we show that in a mouse model in which we deleted two of titin's C-zone super-repeats, thick filam

294 we found that ectopically expressing Id1 or deleting two E protein genes in the thymus drastically i

295 ulated by overexpressing upd3 and rescued by deleting upd3, highlighting a crucial role for this cyto

296 al shape, size and structure when Bmpr1a was deleted using Aggrecan-Cre (ERT2) in early cartilage cel

297 level of RNA replication observed for the 5'-deleted viral genomes-a less stable ribonucleoprotein co

298 titative PCR, we demonstrated that the ORF25 deleted virus infects fish through skin infection and th

299 red RNA synthesis associated with terminally deleted viruses could be due to destabilization of the r

300 the non-homologous proteins are individually deleted, we propose locations for all eight TCPM compone

301 lly conserved minor capsid gene vp3 could be deleted without a loss in infectivity and results in vir