ライフサイエンスコーパス: deleterious

1 that sampled intrahost variants are strongly deleterious.

2 ing question has been why such sequences are deleterious.

3 ch bursts are mutagenic and thus potentially deleterious.

4 function impair microglial signaling and are deleterious.

5 e-strand breaks (DSBs) are probably the most deleterious.

6 he presence of insufficient oxygen supply is deleterious.

7 , compensation would be unnecessary and even deleterious.

8 mpled within-host polymorphisms are strongly deleterious.

9 in ClinVar, although 79.02% are predicted as deleterious.

10 ible effects on fitness and less than 1% are deleterious.

11 ls of enantiopurity and are prone to undergo deleterious acid-base side-reactions under the reaction

12 ermine whether this impact is related to the deleterious actions of AbetaOs on synapses.

13 we propose that although IL-22BP can control deleterious actions of IL-22 in the skin, its limited pr

14 aID to form a repressor complex relieved the deleterious actions of TRalpha1 mutants in vivo.

15 ulations, we suggest that random fixation of deleterious alleles (i) can be an important driver of di

16 The landscape of deleterious alleles and therefore evolutionary potential

17 amino acid changes, increased the number of deleterious alleles by 26%, and shifted the mutational b

18 and subsequent spread led to an increase in deleterious alleles in the domesticate compared to the w

19 western USA, which reduces the prevalence of deleterious alleles likely due to the higher long-term e

20 ease can increase the frequency of otherwise deleterious alleles.

21 CRISPR-STOP method is an efficient and less deleterious alternative to wild-type Cas9 for gene-knock

22 amino acid residue, and was predicted to be deleterious although it was found with a low frequency i

23 Several private and deleterious amino acid changes were fixed by random drif

24 have resulted in a large proportion of fixed deleterious amino acid changes, increased the number of

25 Most mutations are deleterious and cause a reduction in population fitness

26 Indels can be deleterious and contribute to disease susceptibility as

27 deletion, and missense variants predicted as deleterious, and followed them up in 1, 559 population-b

28 work, we identify biallelic rare, predicted-deleterious ARMC9 variants (stop-gain, missense, splice-

29 therapeutic approaches to prevent or dampen deleterious aspects of "stress." While the renin-angiote

30 pparently protective effects of VitD and the deleterious associations of lymphangiogenesis with renal

31 enol or phthalate metabolite exhibited clear deleterious associations simultaneously with several res

32 Isolated trends for deleterious associations were also observed between 2,5-

33 Eight of 53 patients (15.1%) harbored a deleterious BRCA2 mutation.

34 We associated deleterious BRF1 variants with 1.4% of familial CRC case

35 ve loss-of-function variants predicted to be deleterious by ALoFT are enriched in known driver genes.

36 es data quality by minimizing formation of a deleterious by-product, reducing ligation bias, and impr

37 000 in control data sets and predicted to be deleterious (by combined annotation-dependent depletion,

38 A deleterious c.2715 + 1G > A mutation in the Fanconi anem

39 ty of the cells and molecular events driving deleterious calcification of heart muscle remains elusiv

40 innate immune system response that leads to deleterious cardiac remodeling.

41 Trans-fatty acids (TFAs) have deleterious cardiovascular effects.

42 that the mutation R61T is able to rescue the deleterious cellular effects of ApoE4 by preventing the

43 systematic review describing the positive or deleterious changes on the alveolar bone surrounding nat

44 ate of the reaction centre and to outcompete deleterious charge recombination.

45 ariability was a significant risk factor for deleterious clinical outcomes.

46 Our study reveals a deleterious consequence in intestinal bacterial infectio

47 e repetitive spiking can also therefore have deleterious consequences for spike frequency.

48 omposition, may have important beneficial or deleterious consequences for the colonic epithelial cell

49 air inevitable DNA damage while avoiding the deleterious consequences of imprecise repair.

50 n the intrinsic function of proteins and the deleterious consequences of their misfolding.

51 to their current use, and assess some of the deleterious consequences of these confusions.

52 the resolution of inflammation and leads to deleterious consequences on neurological outcome in adul

53 act the regulation of the immune system with deleterious consequences.

54 t to prevent mistimed dsDNA breaks and their deleterious consequences.

55 fined as loss-of-function or predicted to be deleterious/damaging are rare in cutaneous melanoma.

56 hat preserves naivete and prevents premature deleterious developmental decisions.

57 Double strand breaks (DSBs) represent highly deleterious DNA damage and need to be accurately repaire

58 an aberrant activation of STAT3, leading to deleterious downstream effects in pancreatic beta-cells.

59 However, IL-1beta deleterious effect does not appear to be completely driv

60 ciency for up to 2 years of age has no major deleterious effect in rodents of different genetic backg

61 ovide the first experimental evidence of the deleterious effect of acute LAI on atrial structural rem

62 The deleterious effect of CG dinucleotides on HIV-1 replicat

63 ictive effect ( P = .04) was observed with a deleterious effect of chemotherapy with TP53/KRAS comuta

64 cesses ranging from acuity and crowding (the deleterious effect of clutter on object recognition) to

65 combination of a frozen accident, i.e., the deleterious effect of codon reassignment in the SGC, and

66 lthough previous research has documented the deleterious effect of continuous OCS exposure in patient

67 The deleterious effect of genomic disorders on neurocognitiv

68 strated that both steps were critical in the deleterious effect of IL-1beta on Treg differentiation.

69 Our results suggest an independent causal deleterious effect of overweight and obesity on current

70 n identifies patients who do not suffer this deleterious effect of rFVIII.

71 h CO2 on Trichodesmium is overwhelmed by the deleterious effect of the concomitant decrease in ambien

72 Water binding is suggested to be key in the deleterious effect of wheat bran on bread quality.

73 factors associated with poverty that have a deleterious effect on children's development.

74 fect the core protein structures and have no deleterious effect on essential biological processes.

75 nation of AURKA and MEK inhibitors induces a deleterious effect on mutant KRAS cells.

76 In addition, we show that aging has a deleterious effect on nAChR efficacy.

77 fection in the mosquito, but it has a strong deleterious effect on sporozoites and reduces malaria tr

78 Power assertion parenting had a deleterious effect on the extent of gingival bleeding vi

79 However, inflammation can also have deleterious effect on the host and is tightly regulated.

80 t evidence of effect modifications by CKD or deleterious effect on the main kidney outcome.

81 to interact with both protein families has a deleterious effect on virus growth.

82 t host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for

83 CRISPR-Cas9-induced DNA damage may have deleterious effects at high-copy-number genomic regions.

84 structure permitted a fresh analysis of the deleterious effects caused by K1/K10 missense mutations

85 These deleterious effects culminated in the activation of the

86 nd in surface waters and are associated with deleterious effects in fish populations.

87 ly, URB597 (1 mg/kg, i.p.) was devoid of any deleterious effects in normal conditions, while it preve

88 ultaneously advance general knowledge of the deleterious effects of an increasingly common natural to

89 ing and may, therefore, underpin some of the deleterious effects of anxiety on higher-order cognition

90 Because of the deleterious effects of circulating MPO, there is a great

91 rons, a potential strategy for reversing the deleterious effects of DOX treatment.

92 dietary intervention may mitigate potential deleterious effects of elevated plasma ceramide concentr

93 tive bursts to prime crop plants against the deleterious effects of environmental stresses and toxins

94 transcriptomic changes and, potentially, in deleterious effects of exposure.

95 The deleterious effects of Gbeta5 are not restricted to VCM,

96 ms by which exercise ameliorates some of the deleterious effects of high fat feeding, we investigated

97 property could be engineered to minimize the deleterious effects of IFNalpha expression that occur du

98 sensitized to RA and more vulnerable to the deleterious effects of increased RA signaling.

99 experimental data, our findings support the deleterious effects of late systolic loading on ventricu

100 Understanding the deleterious effects of long-term RV apical pacing in vul

101 ioned SCZ-related phenotypes, highlights the deleterious effects of Mirta22 up-regulation.

102 d that a pollen rich diet can compensate the deleterious effects of mite parasitization.

103 based solutions are needed to ameliorate the deleterious effects of neighborhood disadvantage on heal

104 Abstract: Addressing deleterious effects of noncoding mutations is an essenti

105 a panel of proposed methods for quantifying deleterious effects of noncoding mutations to precompute

106 y in the fat body protected animals from the deleterious effects of overnutrition, whereas downregula

107 ular effects and could serve to mitigate the deleterious effects of polycythemia rather than reduce p

108 nd can offer key "early warning signs" about deleterious effects of predicted change.

109 hat protects the gastrointestinal tract from deleterious effects of radiotherapy will significantly i

110 es also have the advantage of minimizing the deleterious effects of random factors affecting parasite

111 Yet, it is unclear how Plasmodium avoids the deleterious effects of selective autophagy.

112 r stress after overturning and the typically deleterious effects of strong turbulence on motile phyto

113 which can be imaged by MR and which have no deleterious effects on cell proliferation, migration or

114 d repeated overuse can lead to addiction and deleterious effects on health.

115 eutrophils exert predominantly protective or deleterious effects on loss of B cell self-tolerance in

116 paramagnetic DNP polarizing agents can have deleterious effects on NMR signals.

117 tent, and these mutations were found to have deleterious effects on nodule development and function.

118 The potentially deleterious effects on offspring health of excess matern

119 evels exceeding 60%, a level associated with deleterious effects on oxidative phosphorylation.

120 eme changes in sunlight, potentially causing deleterious effects on photosynthetic efficiency and pro

121 atory and proliferative diseases without the deleterious effects on stomach mucosa.

122 ctive necrosis of solid tumors, with limited deleterious effects on surrounding normal tissues.

123 tric improvement of the LES without apparent deleterious effects on the esophageal body.

124 the mechanism by which the drug induces its deleterious effects on the parasite.

125 o be inactivated or inhibited because of its deleterious effects on the quality of fruits and vegetab

126 uanylate nucleotide synthesis have selective deleterious effects on TSC-deficient cells, including in

127 ly deprivation was associated with long-term deleterious effects on wellbeing that seem insusceptible

128 tural modeling of missense variants suggests deleterious effects to the encoded proteins.

129 body in myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions a

130 These deleterious effects were attenuated by rapamycin adminis

131 These deleterious effects were due to a CD4 T-cell-dependent i

132 o help avoid C99 accumulation preventing its deleterious effects.

133 s unwanted mutations caused by DSBs can have deleterious effects.

134 beta2-nAChR protected delay cells from these deleterious effects.

135 orward simulations that they jointly predict deleterious effects.

136 cluding non-toxicological and non-chemically deleterious effects.

137 ved to sense cellular RSS and mitigate their deleterious effects.

138 of magmatism must be responsible for driving deleterious environmental effects.

139 aptive response to what would otherwise be a deleterious environmental perturbation.

140 and postoperative complications, as probable deleterious factors contributing to early recurrence.

141 sites at which mutations are likely to have deleterious fitness consequences, and which, therefore,

142 Cholesterol can be deleterious for LS function, a condition that is reverse

143 of whole or partial chromosomes-is typically deleterious for organisms, a hallmark of cancers, and on

144 glucocorticoid exposure has been shown to be deleterious for pancreatic beta-cell function and insuli

145 that the uncontrolled expression of AtHB1 is deleterious for the plant and, hence, finely repressed b

146 motif or its contact amino acid residues is deleterious for viral assembly.

147 utation in a disease protein, and identify a deleterious function of such mutations distinct from the

148 satellite is a distance holder that prevents deleterious fusion of both structures.

149 rs proliferation and activating functions of deleterious gammadeltaT17 cells.

150 Hybrid incompatibility resulting from deleterious gene combinations is thought to be an import

151 Studies of individuals with deleterious genetic variants can elucidate novel roles o

152 8 protein-coding genes for an excess of rare deleterious genetic variation using whole-exome sequence

153 e sequencing data for additional potentially deleterious genetic variations in genes of relevance to

154 se-associated and the much larger set of non-deleterious genomic variation, especially in non-coding

155 associated with a lower incidence of weakly deleterious genotypic mutations.

156 of 854 patients with pancreatic cancer had a deleterious germline mutation, 31 (3.5%) of which affect

157 ith other periampullary neoplasms also had a deleterious germline mutation.

158 Purpose Deleterious germline mutations contribute to pancreatic

159 Deleterious germline mutations were also found in BUB1B

160 th BRCA mutations (carcinoma associated with deleterious germline or somatic BRCA mutations), patient

161 of tumour mutational analysis: BRCA mutant (deleterious germline or somatic), BRCA wild-type and LOH

162 many important functions and help to prevent deleterious HCMV disease in healthy older people.

163 factor for periodontal disease and has many deleterious health effects, treatment of periodontal dis

164 in developed nations and is associated with deleterious health outcomes.

165 mitochondrial fatty acid oxidation initiates deleterious hypertrophic cardiac remodeling independent

166 omotes M2-polarization in order to shut-down deleterious immune responses and limit bystander brain d

167 No product-related serious adverse events or deleterious immune responses occurred.

168 ic microtubule organizations that may have a deleterious impact during neurodegeneration.

169 of mesenchymal stem cells (MSCs) against the deleterious impact of AbetaOs on hippocampal neurons.

170 t prevention of this interaction reduces the deleterious impact of AbetaOs on synapses and cognition.

171 may physiologically protect neurons from the deleterious impact of AbetaOs.

172 s concurrent modulation of cytokines without deleterious impact on the rest of the immune system.

173 content of potted herbs whilst reducing the deleterious impacts of dense planting on product quality

174 finger motif crucial for DNA binding and are deleterious in a fly model.

175 entified 23 nsSNPs to be putatively damaging/deleterious in at least one of the two tools used.

176 2 or more missense variants predicted to be deleterious in each of 3 genes ( ACACB, PTPRS, MIB1) in

177 ow-frequency variants are significantly more deleterious in front than in core individuals, (ii) equa

178 ategies among vertebrates and that is highly deleterious in humans.

179 tory macrophages, in adipose tissue (AT) are deleterious in metabolic diseases.

180 cts of physiological RBC aggregation are not deleterious in terms of in vivo vascular resistance.

181 logeneic islets in the IP site, but resulted deleterious in the EFP site, probably due to lower bioco

182 s from singleton exonic SNPs predicted to be deleterious indicated that cases had significantly more

183 Survival of deleterious infections depends significantly on how much

184 oorly understood and could contribute to the deleterious inflammation and fibrosis of ABMR via suppre

185 chiral ligand concentration can minimize the deleterious influence of achiral Cu-alkyl species, resul

186 out the genome, which decreases the risks of deleterious integration.

187 Deleterious interaction effects were also noted in the d

188 her EspP mutant likewise formed a prolonged, deleterious interaction with the Bam complex but was pro

189 Syndemics investigates synergistic, often deleterious interactions among comorbid health condition

190 It has been suggested that deleterious interactions between the mitochondrial and n

191 ophrenia (PDS) may have increased numbers of deleterious L1 insertions, perhaps occurring de novo, in

192 Childhood maltreatment (CM) confers deleterious long-term consequences, and growing evidence

193 Epidemiological and animal studies show that deleterious maternal environments predispose aging offsp

194 te that even if the mapped SNVs predicted as deleterious may not result in significant structural mod

195 es per gene, with at least one truncation or deleterious missense mutation in more than 90% of the ca

196 herapies in ovarian cancer patients carrying deleterious missense RAD51D variants.

197 F, increased to p = 4.1 x 10(-6) for LOF and deleterious missense variants combined, and augmented fu

198 pulation genetic theory, which predicts that deleterious mito-nuclear interactions are unlikely to be

199 that a combination of R402Q and S192Y with a deleterious mutation in a 'tri-allelic genotype' can acc

200 A higher deleterious mutation rate is observed in the pericentrom

201 ive evolution by exacerbating the effects of deleterious mutations and leading to their more efficien

202 ween two different viruses, thereby removing deleterious mutations and restoring viral fitness.

203 r example, the influence of partially linked deleterious mutations and the maintenance of neutral rea

204 front than in core individuals, (ii) equally deleterious mutations are at higher frequencies in front

205 significantly more abundant in soybeans with deleterious mutations at conserved residues of GmSACPD-C

206 ation leads to the accumulation of recessive deleterious mutations but without decreasing fitness.

207 tational burden toward common variants; (ii) deleterious mutations have been ineffectively purged, ow

208 We found that the deleterious mutations identified in cancer genomes were

209 We identified 14 rare and likely deleterious mutations in 14 genes that were shared ident

210 e deaminase 2 (DADA2) is caused by biallelic deleterious mutations in CECR1 DADA2 results in variable

211 We show by simulation that selection against deleterious mutations in the form of background selectio

212 frica and South America; however, ubiquitous deleterious mutations may severely decrease its fitness.

213 ed populations should adapt faster and clear deleterious mutations more quickly than populations wher

214 Deleterious mutations of Hcfc2 may therefore increase su

215 Deleterious mutations of the ubiquitin carboxy-terminal

216 s and potentially increased the frequency of deleterious mutations on expanding wave fronts.

217 s more likely to be homozygous for rare very deleterious mutations present in Europeans.

218 humans have a higher proportion of strongly deleterious mutations than Drosophila melanogaster.

219 gregation during ploidy reduction can expose deleterious mutations through loss of heterozygosity.

220 mall populations, assuming genetic models of deleterious mutations which account for the typical amou

221 nt of inbreeding depression, and the load of deleterious mutations, as well as for applied research i

222 have a decreased likelihood of small-effect deleterious mutations, thus causing small-population gen

223 To evaluate these deleterious mutations, we constructed a cassava haplotyp

224 thereby preventing creation of embryos with deleterious mutations.

225 age limits the ability of selection to purge deleterious mutations.

226 nism has evolved to withstand the effects of deleterious mutations.

227 their host, associated with accumulation of deleterious mutations.

228 ndividuals were analyzed for their potential deleterious nature and a low frequency in the general po

229 P3A5 as a therapeutic target to mitigate the deleterious neurodevelopmental effects of prenatal cocai

230 tive nitrogen species (RNS) which can effect deleterious nitrative or oxidative (bio)chemistry.

231 their annotation, we found that potentially deleterious non-synonymous mutations (9566 SNPs) explain

232 fication, characterization and validation of deleterious non-synonymous SNPs (nsSNPs) in the interleu

233 rm the methodological advances in predicting deleterious noncoding mutations into a practical resourc

234 xome sequencing, we mapped this phenotype to deleterious nonsense or homeobox domain missense mutatio

235 A model qualifying ultrarare, deleterious, nonsynonymous variants implicated TERT and

236 Rare, deleterious, nonsynonymous, or loss-of-function variants

237 rastructure help to buffer children from the deleterious nutritional effects of precipitation shortfa

238 enerative capacity of damaged nerves without deleterious off-target effects.

239 onstrate that, although leptin treatment was deleterious on cardiac function in control animals, lept

240 However, recent studies have shown deleterious on-target effects of systemic TGR5 agonists.

241 le therapeutic strategy due to the potential deleterious oncogenic activity of this miRNA.

242 sponse assessment while avoiding the risk of deleterious organ progression.

243 and/or myopathy is strongly associated with deleterious outcomes including fewer hospital-free days,

244 These deleterious pancreatic cancer susceptibility gene mutati

245 d cancer genomic studies suggest that mildly deleterious passengers accumulate and can collectively s

246 e cyclic GMP-AMP synthase gene abolishes the deleterious phenotype.

247 These findings demonstrate a deleterious positive feedback loop involving elevated in

248 r the study, only nsSNPs that score damaging/deleterious prediction in both sequence and structural h

249 le others harness the immune system to clear deleterious products and cells.

250 have leveraged the genetic code to identify deleterious protein-coding alleles, but no analogous cod

251 nsatory response to counter this potentially deleterious proteostatic disruption.

252 nnate and adaptive immune response and limit deleterious remodeling following myocardial injury.

253 mospheric particulate matter known to have a deleterious respiratory and cardiovascular impact in hum

254 ) control mice (30%), suggesting OPN plays a deleterious role in WNV infection.

255 Thus, our results suggest a deleterious role of mast cells during the acute inflamma

256 on monitoring was employed to understand the deleterious role of water during the formation of a meth

257 (TBI), glial cells have both beneficial and deleterious roles in injury progression and recovery.

258 ated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA structures, noncoding RNA asso

259 Putative deleterious sequence variants co-segregating with TD pat

260 We conclude that deleterious sequence variants in PBX1 cause intellectual

261 We present eight patients with de novo, deleterious sequence variants in the PBX1 gene.

262 iseases are now viewed as a consequence of a deleterious shift in the balance of the normally stable

263 -deficiency shifted DSB repair toward highly deleterious single-strand annealing (SSA) and end-joinin

264 Our analysis identifies potentially deleterious SNVs present on drug-binding residues that a

265 states at material interfaces provide highly deleterious sources of noise in solid-state nanostructur

266 lpha-synuclein (alphaSyn) might be the major deleterious species for neuronal function in these disea

267 their ability to catalyze the production of deleterious superoxide, the formation of Cu(I)-glutathio

268 which is likely responsible for some of the deleterious symptoms associated with high biological phe

269 een, which led to the identification of new, deleterious synthetic lethal interactions.

270 t radical replacements are more likely to be deleterious than conservative changes.

271 These Anabaptist-specific variants were more deleterious than variants with comparable frequencies ob

272 to the local trigger, as well as to prevent deleterious tissue-damaging bystander effects.

273 that inhibition of Nrxn processing by PS is deleterious to glutamatergic function.SIGNIFICANCE STATE

274 Chromosome instability (CIN) is deleterious to normal cells because of the burden of ane

275 vation of MAPK/ERK in adult SCs is therefore deleterious to successful nerve repair, emphasizing the

276 heart failure (HF) induces molecular changes deleterious to the cardiac cell.

277 CSE is found to be more deleterious to the function of both PDL and gingival fib

278 The resultant hyperglycemia is deleterious to the normal function of many organs and it

279 genome integrity of the animal germline from deleterious transposable elements.

280 However, DSBs, which are the most deleterious type of DNA damage, often result in unintend

281 unrelated families have either a homozygous deleterious variant (c.145delG [p.Glu49Argfs( *)14]) or

282 by an individual bearing an extremely severe deleterious variant (such as aneuploidy) could escape em

283 position and effect of the numerous slightly deleterious variants in humans and model organisms.

284 me sequencing of HLHS fibroblasts identified deleterious variants in NOTCH receptors and other genes

285 fected families, ALoFT distinguishes between deleterious variants in patients and benign variants in

286 analysis showed enrichment of rare predicted deleterious variants in RYR2 (p = 5 x 10(-5)).

287 hality if the genome-wide burden of slightly deleterious variants is sufficiently low.

288 fying selection, and that SVScore identifies deleterious variants more effectively than alternative m

289 riptomes) and observed a deficit of slightly deleterious variants on Chromosome 21 and decreased tran

290 nd that grape accessions contained 5.2% more deleterious variants than wild individuals, and these we

291 Deleterious variants were found at both loci identified

292 Annual crops accumulate putatively deleterious variants, in part due to strong domesticatio

293 notations and to test for enrichment of rare deleterious variants.

294 CPO which might be more often caused by rare deleterious variants.

295 ted of mutations can distinguish potentially deleterious variants.

296 fected by the genome-wide burden of slightly deleterious variants.

297 as different as human history, adaptive and deleterious variation, morphological development, ageing

298 etion of CD36 or Nox2 from PVM abrogates the deleterious vascular effects of Abeta, whereas wild-type

299 gh level of LCN2 in the CNS is protective or deleterious, we challenged Lcn2(-/-) mice with periphera

300 e average selection coefficient becomes more deleterious with increasing species complexity.