ライフサイエンスコーパス: deletion

1 of Notch1 prevents SC depletion despite Pten deletion.

2 network effects that occur 1 week after Pten deletion.

3 omatopsia with Pde6c defect) mice with Thrb2 deletion.

4 n through CRISPR/Cas9-mediated site-specific deletion.

5 s detected only for the 7- and 21-nucleotide deletions.

6 e somatic hypermutation and no insertions or deletions.

7 pe sequence revealed multiple insertions and deletions.

8 c regions recurrently targeted by homozygous deletions.

9 ide variants (SNVs), and elevated amounts of deletions.

10 ree, we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine

11 Mechanistically, Nrp1 deletion activates the nuclear factor-kappaB pathway, wh

12 pes and systematically screen for homozygous deletions, aiming to identify rare tumour suppressors.

13 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-

14 Trpc6 deletion also ameliorated left ventricular dilation, imp

15 ORF7 deletion also impaired transmission of ORF7-deficient vi

16 white adipocyte browning downstream of Egr1 deletion and highlights a concomitant increase of beige

17 ination of the secondary metabolites of xpp1 deletion and overexpression strains using an untargeted

18 ed PennCNV-Seq with other tools with general deletions and duplications, as well as for different num

19 g both ends of the protein, we show that YY1 deletions and missense mutations lead to a global loss o

20 -generation" sequencing (NGS) data to detect deletions and quantify their clonal abundances.

21 ignificantly contributes to the formation of deletions and translocations in G1, which represent impo

22 hondrial elongation, is not mimicked by Drp1 deletion, and is observed in Drp1-deficient fibroblasts.

23 Male, but not female, deletion animals overexpress mRNA for dopamine receptor

24 Deletions appear to have the largest effect on pseudogen

25 To determine whether BACE1 deletion-associated effects in mice generalize to anothe

26 v(+)B cell clones develop anergy and partial deletion at the transitional to mature B cell stage, but

27 lecular consequences of CRISPR/Cas9-mediated deletions at 17 sites in four loci of the mouse genome.

28 that framework to develop a method to locate deletions at base pair level using next-generation seque

29 Our deletion-based approach identified two long intergenic n

30 pab1 deletion brings about a transcriptional profile similar

31 We characterized the genetic deletion by histology, electrophysiology, and microdialy

32 Genomics (BHCMG) cohort and detected 773 HMZ deletion calls (567 homozygous or 206 hemizygous) with a

33 sence of any imaging feature associated with deletion carriers indicated worse daily living, communic

34 mmunication, and social skills compared with deletion carriers without any radiologic abnormalities (

35 ion, and the smaller 1.5 Mb LCR22A-B 22q11.2 deletion carry inversions of LCR22B-D or LCR22C-D.

36 decayed around LanFTc1, suggesting that this deletion caused the loss of vernalization response.

37 DNA double-strand breaks is associated with deletions, chromosome translocations, and genome instabi

38 20,328 substitutions, 88 insertions, and 154 deletions, compared to the EBV reference genome.

39 sequent LP solution subject to this reaction deletion constraint becomes a distinct EM.

40 combination of genetic complementation with deletion constructs and virus overlay assays with indivi

41 Here, we report that FOXP1-SHQ1 deletion cooperates with PTEN loss to accelerate prostat

42 sistant strains arising through further gene deletion could compromise such a strategy.

43 Mechanistically, neuroligin deletions decreased the synaptic levels of neurotransmit

44 APC deletion deregulates beta-catenin, leads to high Wnt ton

45 (E) 14.5 was not affected by homozygous Mof deletion despite dramatic loss of global H4K16ac.

46 We found that neuroligin deletions did not affect synapse numbers but differentia

47 In addition, Mdm2 deletion differed from blocking Mdm2 interaction with p5

48 Here, we report that Necdin deletion disturbs the migration of serotonin (5-HT) neur

49 t of DNA gained by transposition and lost by deletion during mammal and avian evolution, resulting in

50 IPMK deletion elicits a major enrichment of HIF-1alpha protei

51 duals with predicted truncating variants and deletions encompassing BMP2.

52 In contrast, BMPR2 deletion extended survival relative to Pten deletion alo

53 caused a persistent hypomyelination, as did deletion from astrocytes during postnatal development.

54 Tsc1 deletion from NG2(+) OPCs accelerated remyelination.

55 erscores the therapeutic potential of PrP(C) deletion given that patients already present symptoms at

56 However, these 5' deletions greatly reduced the synthesis of viral RNA in

57 The analysis of transgenic 5' upstream deletion::gusA Arabidopsis lines showed that this region

58 Global HDAC11 deletion had no effect on health or development, and com

59 promote synapse formation; and Top3beta gene deletion has been linked to schizophrenia.

60 esults from this study show that hepatic ILK deletion has no effect on insulin action in lean mice bu

61 Moreover, FOXP1-SHQ1 deletion has prognostic relevance, with cancer recurrenc

62 re mice to produce a hepatocyte-specific ILK deletion (ILK(lox/lox)Albcre).

63 They find that tau deletion impairs hippocampal response to insulin through

64 f over 4000 brain cancers we identified ZEB1 deletion in 15% (grade II and III) and 50% of glioblast

65 Of note, SNF1 deletion in combination with MSN2 and MSN4 deletion resu

66 Here, we show that PTEN deletion in HCT116 and DLD1 colon carcinoma cells leads

67 EC-specific deletion in mice of glutaminase, the initial enzyme in g

68 Ep3 deletion in Mos/Mps markedly attenuates healing after MI

69 WBP2 deletion in mouse skin results in reduced proliferation

70 We previously showed that MCPH1 deletion in neural stem cells results in early mitotic e

71 Furthermore, we show that Furin deletion in osteoblasts reduced appetite, a function not

72 Mdm2 deletion in p53(-/-) cells upregulated p53 transcription

73 In vivo, T-cell-specific GR deletion in pregnant animals undergoing experimental aut

74 Spry2 deletion in the adult mouse beta-cell caused hyperglycem

75 atelets, we created a mouse model with Vps34 deletion in the MK/platelet lineage (Pf4-Cre/Vps34(lox/l

76 We found that a deletion in the p27-p55 operon impairs the replication o

77 Stage-specific gene deletion in trophoblasts reveals that loss of both GATA

78 We identified a novel 1 bp deletion in YAP1 in a boy with bilateral microphthalmia

79 Deletion in zebrafish reduced pitx2 expression during de

80 We then constructed sequential deletions in regions that span the 530 bps.

81 inctive mutation signature composed of short deletions in tandem repeats; in the specific case of rib

82 novo heterozygous loss of function mutations/deletions in the PBX homeobox 1 gene (PBX1), a gene know

83 For example, we demonstrate targeted deletions in up to six genes by expressing 12 gRNAs from

84 dary was highly resilient, and only a 400-kb deletion, including the whole-gene cluster, was eventual

85 of quiescence is characterized by insertion/deletion (indels) accumulating as fast as single nucleot

86 equency of both smaller-scale insertions and deletions (indels) and of single-nucleotide variant (SNV

87 ith the contribution of small insertions and deletions (indels) less well characterised.

88 d bases, including miscoding, insertions and deletions (indels), and truncations, to unmodified bases

89 M and human macrophages with Mtb with esat-6 deletion induced diminished STAT3 activation and reduced

90 hanisms, such as chromosomal rearrangements, deletion/insertion, transposon-mediated dispersion, or p

91 GCR2) is located in the 22q11.2 locus, whose deletion is a major risk factor for SZ.

92 is reveals that this cascade induced by UCP1 deletion is associated with a dramatic reduction in elec

93 sis serous subtype tumours, and this genetic deletion is associated with poor overall survival.

94 To better understand how gene deletions lead to altered neuronal activity, we investig

95 We found that tau deletion leads to an impaired hippocampal response to in

96 We generate double-gene deletion libraries to demonstrate this technology, targe

97 Interestingly, lines with deletions located downstream of the motif show even lowe

98 the topology of the K2 FERM domain, and its deletion may affect the positioning of the membrane-bind

99 wo copies of nuclear chromosomes), and mtDNA deletions may be present on only a very small percentage

100 discusses progress in the area of insertion-deletion models, in view of recent work by Ezawa; on the

101 or progression in the prostate-specific Pten deletion mouse model for prostate cancer.

102 old or more) up- or down-regulated in a scmR deletion mutant (DeltascmR) Metabolically, the DeltascmR

103 cell function, we analyzed how an endogenous deletion mutant affected Pdx1 expression embryonically a

104 ion of wild-type Pdcd4 and Pdcd4(157-469), a deletion mutant that binds to translation initiation fac

105 Deletion mutants exhibited a range of translational phen

106 A recent study by Laplante et al.[3], using deletion mutants of myp2 and myo51 and the mis-sense mut

107 We tested several candidate miRNA-deletion mutants post gamma-irradiation and identified c

108 into a pool of 4653 homozygous diploid yeast deletion mutants with unique barcode sequences, followed

109 Each gene has a coding sequence insertion/deletion mutation within the SC species that produces a

110 Similarly, in the subset with KIT exon 11 deletion mutations, higher-than-the-median mitotic count

111 WWOX gene deletions occur in a variety of human cancer types, and

112 CTCF genetic deletion occurs predominantly in poor prognosis serous s

113 Deletion of a recruitment site on the X results in reduc

114 Deletion of a third gene from pigs resulted in 30% of hu

115 binds AC9 in a Yotiao-independent manner and deletion of AC9 decreases Hsp20-associated AC activity i

116 Here we show that genetic deletion of alpha2delta-1, the dominant alpha2delta subu

117 We further demonstrated that deletion of ami1 leads to increased cell wall permeabili

118 However, HPRT1 function was robust to deletion of any intergenic or deeply intronic non-coding

119 (Treg) cells, and mice with T cell-specific deletion of Blimp1 (Blimp1CKO mice) spontaneously develo

120 o the dopa-responsive dystonia, as well as a deletion of BMP4 as a potential cause of digital and eye

121 In addition, deletion of C/EBPalpha in MDSCs enhanced the pro-angioge

122 Here we show that embryonic deletion of Cacna1c in forebrain glutamatergic neurons p

123 ficient (Ldlr-/-) mice with myeloid-specific deletion of CaMKII had smaller necrotic cores with conco

124 elective inhibition of T-channels and global deletion of CaV 3.1 channels completely suppressed devel

125 Here, we show that specific deletion of CB1R in the renal proximal tubule cells did

126 ediated cell proliferation was unaffected by deletion of CD44.

127 In contrast, deletion of Cdc42 in alveoli cells prevents Kras (G12D)

128 Deletion of Cdkn1a rescues the GC reaction in Ezh2 (-/-)

129 Finally, systemic deletion of Cldn14 completely rescued the hypercalciuric

130 demonstrate that mice with general inducible deletion of CLEC-2 or platelet-specific deficiency in CL

131 ated the progression of PDA in mice, whereas deletion of Clec7a-the gene encoding dectin 1-or blockad

132 ing the capsule ctr-css operons and adjacent deletion of cssA/B/C and a part of csc, encoding the ser

133 Mice with cardiac-specific deletion of CTCF (a ubiquitous chromatin structural prot

134 Deletion of CTCF sites compromises enhancer-promoter int

135 ulation of OXPHOS, inhibition of the PTP, or deletion of CypD increased high order synthasome assembl

136 NAs in glial function, we used a conditional deletion of Dicer1 (Dicer-CKOMG) in retinal Muller glia

137 DLX3-null keratinocytes, we performed acute deletion of DLX3 in adult epidermis using a tamoxifen-in

138 , lptD4213, is synthetically lethal with the deletion of dsbB as well as with DsbB inhibitors.

139 Inducible postnatal deletion of Dsp under the transcriptional control of the

140 Deletion of EDE1 results in fewer CME initiations and de

141 Furthermore, tamoxifen-induced deletion of EGFR from epithelial cells of established in

142 Deletion of EGFR from intestinal epithelial cells did no

143 Deletion of either Egfr or Axl decreased the tumorigenic

144 Sirt1 in endothelial cells, and conditional deletion of endothelial Sirt1 in mice, promotes ER stres

145 e with allergen and that macrophage-specific deletion of ERalpha impaired this M2 polarization.

146 Deletion of ERalpha in kisspeptin cells decreased glutam

147 on in response to oxLDL and targeted genetic deletion of ERK5 in murine platelets prevented oxLDL-ind

148 Moreover, human embryonic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ecto

149 Correspondingly, engineered deletion of Fes accelerated tumor progression in a BRAFV

150 Deletion of FgSRP1 also reduced ascospore ejection and d

151 Genetic deletion of Fos and Dusp1 suppressed tumor growth in a B

152 Genetic deletion of GABAB receptors from dopamine neurons in adu

153 UGBP1, we generated mice with liver-specific deletion of Gank.

154 LSEC-restricted deletion of Gata4 caused transformation of discontinuous

155 These rearrangements included a deletion of GCH1, which likely contributes to the dopa-r

156 The deletion of genes from the wca operon caused a persisten

157 ued on activation of ER stress by additional deletion of Grp78.

158 Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction in the n

159 Myeloid-specific deletion of Hif1a, Epas1, or both together, had no impac

160 23) by thymic APCs is insufficient to induce deletion of high- or low-affinity InsB9-23-reactive CD4(

161 antibody administered to Sphk2(-/-) mice or deletion of Ifng (Sphk2(-/-)Ifng(-/-) mice) blocked the

162 Based on a patient with a full deletion of IGSF1 clinically followed from neonate to ad

163 ad little effect on activity, and sequential deletion of individual glutamates in GC-A-8E progressive

164 In this study, we report that deletion of intestinal nuclear receptor corepressor 1 (N

165 e neither MMB treatment nor myeloid-specific deletion of JAK2 affected FPN1 expression.

166 Treg-specific deletion of Lkb1 in mice causes loss of Treg number and

167 We find that the deletion of LMP2A alone has little effect on the ability

168 creased in the intestine of mice with global deletion of Lpar1, Lpar1(-/-) (Lpa1(-/-)).

169 C]aspartate was preferentially sensitive to deletion of LRRC8C+LRRC8E, but unaffected by downregulat

170 cancer cell migration, silencing or genetic deletion of MCT1 in vivo inhibited migration, invasion,

171 rand (TS/NTS) repair ratio demonstrated that deletion of mfd globally shifts the distribution of TS/N

172 onstrate that mice with endothelial-specific deletion of miR-322 (miR-424 ortholog) and miR-503 have

173 The deletion of misR or misS severely reduced the capacity o

174 SP into distinct fragments in vitro, and the deletion of Mmp9 caused improper processing of DSP in na

175 rsion in the tumor microenvironment, and the deletion of moesin from recipient mice supported the rap

176 Conditional deletion of Mof in a mouse model of MLL-AF9-driven leuke

177 We show that specific genetic deletion of monocyte-derived alveolar macrophages after

178 The deletion of mybA resulted in a very significant reductio

179 coincides with myoblast fusion, and genetic deletion of myomixer using CRISPR/Cas9 mutagenesis aboli

180 re reduced in KW versus HW (P<0.01), whereas deletion of Nox1 in KW mice normalized dilation.

181 Conversely, inducible deletion of one allele of Dkk1 in Osx-expressing cells i

182 Deletion of P1 CTD, but not P2 CTD reduced the affinity

183 oma, silencing of p16/Ink4a is sustained and deletion of p19/Arf is detected, recapitulating human di

184 Deletion of p205 in B16 melanoma cells using CRISPR/Cas9

185 l profile similar to TORC1 inactivation, and deletion of pab1 overcomes the repression of differentia

186 Specific deletion of paxillin in postmitotic neurons using Nex-Cr

187 ufficient to suppress antitumor immunity, as deletion of PD-L1 on highly immunogenic MC38 tumor cells

188 mented copper-specific defects observed upon deletion of PIC2 Additionally, assays in Lactococcus lac

189 We found that deletion of PiT1 or PiT2 blunted the Pi-dependent ERK1/2

190 Moreover, premature postnatal deletion of Pofut1 in skeletal myofibers can induce agin

191 e studied AAI in mice with a T cell-specific deletion of recombination signal-binding protein for imm

192 Mutant dl1015, with deletion of residues 338 to 347 in the C-terminal region

193 We report that deletion of Ric-8b in olfactory sensory neurons prevents

194 Selective deletion of Rictor in macrophages prevents M2 differenti

195 Deletion of sdrD from S. aureus subsp. aureus strain NCT

196 In contrast, homozygous deletion of Sirt1 triggers cellular apoptotic pathways,

197 NE uptake by SAMs is prevented by genetic deletion of Slc6a2 or inhibition of the encoded transpor

198 In Necdin-KO pups, the genetic deletion of Slc6a4 or treatment with Fluoxetine, a 5-HT

199 Deletion of Smad2/3 or Tgfbr1/2 from cardiac fibroblasts

200 Moreover, inhibition or deletion of SphK1 prolonged the lifetime of sphingosine-

201 egulation of lymphocyte trafficking, whereby deletion of Spns2, either globally or in a lymphatic end

202 Deletion of sse and sagA in MGAS315 synergistically redu

203 Correspondingly, beta-cell-selective deletion of StarD10 in mice led to impaired glucose-stim

204 Conditional deletion of T-bet from B cells impaired the formation of

205 T cell-specific deletion of talin in Tln1(fl/fl)Cd4(Cre) mice resulted i

206 mutant mouse models with induced conditional deletion of TGF-beta signaling in the entire eye, the re

207 nd extracellular matrix remodeling, although deletion of Tgfbr1/2 uniquely altered expression of an a

208 Strikingly, deletion of the APC/C subunit Apc15 mimics mutations in

209 Genetic deletion of the beta2 AR led to a normalized adrenergic

210 Here we show that deletion of the cohesin-loading factor Nipbl in mouse li

211 rvention, in particular, because the somatic deletion of the CXCR4 gene in mice is embryonically leth

212 Deletion of the distal CTCF-binding site results in loss

213 Tellingly, both deletion of the flagellin gene and straight filament (ha

214 Deletion of the genes encoding these enzymes significant

215 However, targeted deletion of the Lipa gene in mice decreased the liver le

216 me (AS) is a neurogenetic disorder caused by deletion of the maternally inherited UBE3A allele and is

217 Generation of a novel mouse line, with deletion of the miR-223 binding site in the NLRP3 3' unt

218 Deletion of the MoVRP1 gene resulted in defects in veget

219 Using mice with tissue-specific deletion of the mTORC1 regulator Raptor in alpha cells (

220 Importantly, embryonic deletion of the same gene in astrocytes, or in astrocyte

221 sis likely contribute to UPR activation, but deletion of the unfolded protein stress-sensing luminal

222 Simultaneous deletion of these shadow enhancers in embryonic stem cel

223 ntains a distinctive RNA-binding domain; and deletion of this domain diminishes the amount of Top3bet

224 We show that deletion of this entire region results in a male-to-fema

225 Therefore, deletion of this gene can provide a target for the ratio

226 Deletion of this locus via CRISPR-Cas9 leads to deregula

227 Deletion of TK0566 (encoding Eta) is possible, but resul

228 g-term skin carcinogenesis study showed that deletion of TRAF1 in mice results in a significant inhib

229 In these mice, deletion of TSP-1 ameliorated loss in volume and mass of

230 ination at H2A Lys-119 as both knockdown and deletion of USP7 results in decreased levels of uH2AK119

231 ated the activity of the small GTPase CDC42, deletion of which caused severe defects in endothelial m

232 Deletion of YY1 binding sites or depletion of YY1 protei

233 eletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; an

234 We found that conditional genetic deletions of neuroligins caused no change or only a smal

235 Recombinant viruses harboring engineered deletions of specific virulence-associated genes induce

236 Mutations and deletions of the interleukin-1 receptor accessory protei

237 Focal deletions of the RanBP6 locus on chromosome 9p were foun

238 al adenocarcinoma (PDAC) frequently contains deletions of tumour suppressor gene loci, most notably S

239 t study, we characterized the effect of PKM2 deletion on baseline functioning and survival of photore

240 A somatic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ he

241 The detailed analysis of the impact of deletions on proteins or nucleic acids can reveal import

242 Deletion or amplification of IDH1 was followed by clonal

243 mmunity can occur as a consequence of either deletion or anergy of antigen-specific T cells; inductio

244 s direct editing of the mutation, multi-exon deletion or complete gene correction via homologous reco

245 rms complexes with PBP2a and PBP2b, and that deletion or depletion of GpsB prevents closure of the se

246 or flanking rather than coinciding with the deletion or duplication sizes.

247 Cytogenetic Central Register with a 22q11.2 deletion or duplication was performed.

248 inically identified individuals with 22q11.2 deletion or duplication.

249 ls of progressive kidney disease, global Mif deletion or MIF inhibition also worsened fibrosis and in

250 70% of cancer patients showed a heterozygous deletion or missense mutations in PPP2R4 Cancer-associat

251 F-resistant intestinal inflammation, genetic deletion or pharmacological blockade of OSM significantl

252 To that end, the effects of various gene deletions or chemical blocking agents were tested by inv

253 ide variants and 12.6 de novo insertions and deletions or copy number variations per ASD subject.

254 To identify indicators of deletions or duplications at the 22q11.2 locus and estim

255 We identified BRPF1 deletions or point mutations in six additional individua

256 ound that small molecule inhibition, genetic deletion, or acute depletion of MELK did not significant

257 IKBKG (c.518+2T>G, resulting in an in-frame deletion: p.DelQ134_R256).

258 Surprisingly, indel (insertions and deletions) percentages averaged nearly 70% within 7 d po

259 or chronic inactivation of RNF145 by genetic deletion, potentiates the expression of cholesterol bios

260 Furthermore, NE deletion prevents HFD-induced vascular leakage.

261 FX deficiency and GMDS deletion produce the same biochemical phenotype of GDP-f

262 We studied whether myeloid Bmal1 deletion promotes atherosclerosis by enhancing monocyte

263 ogether, these studies demonstrate that Nat1 deletion promotes reduced mitochondrial activity and is

264 Cfh deletion protected the mice from the pathogenic subretin

265 Recent evidence has revealed that SLC13A5 deletion protects mice from high-fat diet-induced hepati

266 Finally, we observed that Sirt2 deletion reduced cell viability in response to iron defi

267 (13)C-flux analysis showed that Pkm2 deletion reduced the flow of glucose carbons into lactat

268 In mice, PTP1B deletion reduces axonal TrkA levels and attenuates neuro

269 PWS patients define a 91-kb minimum critical deletion region encompassing 3 genes, including the nonc

270 deficient for a gene in the minimal critical deletion region for PWS (Snord116p-/m+).

271 le within IPF lung tissue and senescent cell deletion rejuvenates pulmonary health in aged mice.

272 used for conditional hair cell-specific gene deletion/reporter gene activation in the inner ear.

273 Detecting mtDNA deletions requires special care.

274 1 deletion in combination with MSN2 and MSN4 deletion resulted in additive effects on CCC1 transcript

275 The stg deletion resulted in increased adherence to M cells and,

276 te (PI3P) was significantly reduced by Vps34 deletion, resulting in endocytic/trafficking defects.

277 We find that neuron-specific Tsc1 deletion results in an increase in CTGF secretion that n

278 Acinar Sec23b deletion results in induction of ER stress and increased

279 Dnmt3a/b deletion retards ES cell transition, correlating with de

280 ciate with neuroblastoma cases harboring 11q deletion (rs10895322), using GWAS in 113 European-Americ

281 Tumors with combined Foxp1-Shq1 and Pten deletion show increased proliferation and anaplastic ded

282 A pufQ deletion strain synthesises low levels of bacteriochloro

283 proteinase (MMP) gene member, MMP20, and 11q-deletion subtype neuroblastoma.

284 Chromosome 22q11.2 deletion syndrome (22q11.2DS) is associated with a more

285 Although 22q11.2 deletion syndrome (22q11DS) is associated with early-lif

286 enia occurs in 30% of individuals with 22q11 deletion syndrome (22q11DS), a population who are haploi

287 f(16)A(+/-) mice, an animal model of 22q11.2 deletion syndrome, one of the most common genetic risk f

288 However, regions contained within the 530 bp deletion that could be responsible for modulation of leu

289 tation was found to be due to one nucleotide deletion that would truncate the deduced product and rem

290 , we programmed 4,342 overlapping 1 and 2 kb deletions that tiled 206 kb centered on HPRT1 (including

291 ansmitting the de novo 3 Mb LCR22A-D 22q11.2 deletion, the reciprocal duplication, and the smaller 1.

292 Cx36 deletion therefore disrupts normal regulation of sympath

293 ells with oncogenic PIK3CA mutations or PTEN deletion to grow using diverse amino acid sources.

294 by Gab2 overexpression and impaired by Gab2 deletion via regulation of Jak2 and signal transducer an

295 age tracing approaches and the effect of Smo deletion was examined in the injured entheses.

296 By repairing the deletion, we resurrected 11 alleles of KIR2DP1(F) , the

297 Through CRISPR/Cas9-mediated deletions, we demonstrate a physiological role for intra

298 determinant, Ser5 mutants bearing C-terminal deletions were created.

299 date antigen; however, a naturally occurring deletion within an immunogenic domain is present at high

300 However, pfhrp2 gene deletions yielding false-negative RDTs, first reported i