ライフサイエンスコーパス: deletion mutation

1 Finally, we generated an ftsH deletion mutation.

2 red the Op phenotype in strains with the wzb deletion mutation.

3 t with a dominant negative mechanism for the deletion mutation.

4 or a GAA expansion and a FXN point/insertion/deletion mutation.

5 redominantly a -2 frameshift GC dinucleotide deletion mutation.

6 ng to a mature form was unaffected by either deletion mutation.

7 homologous recombination defect as the rad50 deletion mutation.

8 confirmed by construction of an independent deletion mutation.

9 r frequency of single base substitution than deletion mutations.

10 ional factor contributing to the bias toward deletion mutations.

11 pecies transgene rescue and more recently on deletion mutations.

12 ression of homology-mediated duplication and deletion mutations.

13 latter sequences mimic the bulged SMI for -2 deletion mutations.

14 e generation of more mutations, particularly deletion mutations.

15 ccumulated homology-mediated duplication and deletion mutations.

16 ression of homology-mediated duplication and deletion mutations.

17 , including some with nonsense and insertion/deletion mutations.

18 ermined the locations, rates, and extents of deletion mutations.

19 and used it to screen a series of point and deletion mutations.

20 se activity, with each of approximately 4700 deletion mutations.

21 eshift mutations, as well as splice-site and deletion mutations.

22 We discovered 1 patient with an intronic deletion mutation, 4 patients with point mutations withi

23 ons of single fibers demonstrated that these deletion mutations accumulate to detrimental levels (>90

24 origin, we constructed consecutive internal deletion mutations across the core domain of a KSHV ori-

25 ogenase subunits NifD and NifK, and 2OG or a deletion mutation affecting the T-loop of NifI(2) preven

26 ni, in the mid-region of PS1, and the exon 9 deletion mutation all change the spatial relationship be

27 CLL/small lymphocytic lymphoma harboring ATM deletions/mutations; all but 1 patient had a decrease in

28 ming this interpretation, a constructed vanS deletion mutation also resulted in constitutive expressi

29 on proteolytic susceptibility and C-terminal deletion mutations also confirms the proposed structure.

30 These deletion mutations also rescue the MMS sensitivity of es

31 were identified by measuring the effects of deletion mutations, amino acid substitution mutations, a

32 Deletion/mutation analyses indicated that each of the th

33 Deletion mutation analysis demonstrated the importance i

34 Deletion mutation analysis identified the LSF-responsive

35 Using deletion mutation analysis in combination with biochemic

36 Deletion mutation analysis revealed a putative polarizat

37 Deletion/mutation analysis of reporter constructs was us

38 Further deletion/mutation analysis revealed that multiple transc

39 riptional activation by UVB in HFK, promoter deletion/mutation analysis was performed.

40 An aprA deletion mutation and a mutation in gene for a putative

41 Deletion mutation and gene knockdown assays revealed tha

42 Deletion mutation and site-directed mutagenesis experime

43 lines to demonstrate exon skipping from the deletion mutation and the activation of a cryptic splice

44 Using a series of deletion mutations and chimeric receptors of p75(NTR) an

45 We carried out a series of deletion mutations and chimeric swaps within the leucine

46 Co-expression of CIITA with deletion mutations and collagen promoter constructs demo

47 ntaneously arising and MMS-induced insertion/deletion mutations and large rearrangements were also mo

48 We also detected three short deletion mutations and no insertions, giving a deletion

49 ation have a unique association with exon 19 deletion mutations and show distinct clinicopathologic f

50 n protein, we generated over 40 missense and deletion mutations and tested their phenotypes in biolog

51 We further analyzed the deletion mutations and the Rai1(-/+) allele in a pure C5

52 Exon 19 deletion mutations and the single-point substitution mut

53 he plasticity of gD to tolerate insertion or deletion mutations and to construct an oncolytic HSV-1 t

54 Deletions, mutations and promoter DNA hypermethylation c

55 ucleotide substitutions, small insertion and deletion mutations, and large genomic duplications and d

56 ion, remains chromatin-associated, generates deletion mutations, and maintains cell growth.

57 C, was examined by Ala scanning mutagenesis, deletion mutations, and mutant cycle analyses.

58 REB) protein in Caco2-BBE cells, whereas our deletion, mutation, and CDX2 overexpression analyses dem

59 riety of mechanisms including amplification, deletion, mutation, and epigenetic silencing.

60 Alterations--such as deletion, mutation, and proteolytic cleavage events--to

61 By promoter deletion, mutation, and transient transfection analyses,

62 genesis is a multistep process that involves deletions, mutations, and changes in expression of genes

63 ng the alterations newly identified, genomic deletions, mutations, and rearrangements recurrently tar

64 Novel deletion mutations are detected at c.739-742delAAAG in L

65 Deletion mutations are found to have the largest effect

66 ter vinelandii and some other bacteria, glnD deletion mutations are not lethal in R. rubrum.

67 ate is surprisingly high, and that insertion-deletion mutations are unexpectedly common.

68 This hydrogen bond network, along with a deletion mutation at alpha53, may lead to HLA-DM insensi

69 Analyses of insertion/deletion mutation at six repeat-sequence (microsatellite

70 Less common point and in-frame deletion mutations at codons 591 to 603 remain incomplet

71 The high prevalence of deletion mutations at Pitx1 may be influenced by inheren

72 Patients with KIT exon 11 deletion mutations benefit most from the longer duration

73 The erb1Delta161-200 and erb1Delta201-245 deletion mutations block a later step than depletion of

74 olymerase lambda, which frequently generates deletion mutations, bound to such intermediates.

75 (Delta170)-F1 vector, bearing an attenuating deletion mutation (C(Delta170)) in the P/C gene and expr

76 e mutations (E399K, G709E and T754M) and one deletion mutation (c.99-100delTC)] absent in ethnically

77 The deletion mutation causes a shift of the rate-limiting st

78 enetic array analysis with a clathrin CLC-NT deletion mutation (clc1-Delta19-76).

79 r of smaller-sized bands (representing mtDNA deletions/mutations) compared with normal corneas.

80 Experiments with deletion/mutation constructs have revealed the importanc

81 Analyses with deletion/mutation constructs reveal that protein domains

82 r shows that the naturally occurring robl(Z) deletion mutation contains the majority of the IC bindin

83 In-frame deletion mutation (Del-L955) in NaV1.7 sodium channel fr

84 ies show that a naturally occurring in-frame deletion mutation (Del-L955) of NaV1.7 channel, identifi

85 KIT exon 11 deletion mutations, deletions that involved codons 557 a

86 xotrophic Salmonella vaccine strain with the deletion mutation Delta(wza-wcaM)8 developed higher vagi

87 es of a Bacillus subtilis strain with a gerD deletion mutation (Delta gerD) responded much slower tha

88 E111A, R116V/K118A, and R160V/H162A, and two deletion mutations, Delta(61-78) and Delta(121-142), on

89 the primary loop, W180G and Y185G, plus the deletion mutation Delta491RSRR494 and point mutation 491

90 A partial AP deletion mutation (DeltaAP) also confers a Tra(+) Pil(-)

91 Recently, an in-frame deletion mutation (DeltaE81) in a conserved region from

92 phatase assays utilizing a virus with a UL97 deletion mutation (DeltaUL97 virus) indicated that Cdh1

93 The deletion mutation described resulted in a frameshift, pr

94 PCR products confirmed that this was a 2-bp deletion mutation, designated c.442delAG, leading to a p

95 Multiple quadruple Ser-to-Ala and deletion mutations did not disrupt the phosphorylation o

96 ion of C57Bl/6 mice heterozygous for a Gata4 deletion mutation died within 1 day of birth.

97 NA ternary complex was inhibited unless a 5' deletion mutation disrupted the second stem-loop structu

98 Likewise, deletion mutations disrupting the apoE-NS5A interaction

99 wn as CDX-110), a vaccine targeting the EGFR deletion mutation EGFRvIII, consists of an EGFRvIII-spec

100 Accordingly, the leu2Delta deletion mutation exacerbated Aco1p inactivation in cell

101 , our data provide an example of an in-frame deletion mutation exerting a 'polar' effect on nearby ge

102 A Myo1B deletion mutation exhibited normal larval gut physiology

103 t domains in the Ctr9 sequence, and based on deletion mutation experiments, we demonstrated the role

104 Deletion/mutation experiments have revealed the importan

105 A deletion mutation for type IX collagen is associated wit

106 The deletions/mutations found in DLBCLs are largely monoalle

107 ment did not increase mitochondrial point or deletion mutation frequencies, despite evidence both com

108 ients with KIT exon 11 deletion or insertion-deletion mutation had better RFS when allocated to the 3

109 Seven missense mutations and one in-frame deletion mutation have been reported in the coagulation

110 Although mitochondrial DNA (mtDNA)-deletion mutations have been shown to accumulate with ag

111 As shigellae expressing ipaD N-terminal deletion mutations have reduced contact-mediated hemolys

112 Similarly, in the subset with KIT exon 11 deletion mutations, higher-than-the-median mitotic count

113 to generate Hsp70-deficient virions with gag deletion mutations, Hsp70 transdominant mutants, or RNA

114 HV mutational status, 11q deletion, and TP53 deletion/mutation identified CYP2B6*6 and TP53 mutation/

115 ng, the modified nucleotide is reported as a deletion mutation, identifying its location.

116 The promoter-null point mutations and 6-bp deletion mutations implied that the carQRS promoter requ

117 of the PITX3 gene revealed a heterozygous G deletion mutation in 25 of the 42 family members.

118 We report a novel, homozygous, deletion mutation in a child of Nicaraguan descent in ex

119 Here, we describe a 15-base pair deletion mutation in a regulatory element of GPR56 that

120 vl indicates these phenotypes result from a deletion mutation in an uncharacterized orphan G protein

121 -catenin or the prominent cancer-related S45 deletion mutation in beta-catenin present in human colon

122 l pcd(Sid) mice and linked this deficit to a deletion mutation in exon 7 of Nna1.

123 tica strain RBX9, which contains an in-frame deletion mutation in fhaB, encoding filamentous haemaggl

124 A deletion mutation in GRR1, encoding a component of the S

125 reated Apc(Min) mice that carried a targeted deletion mutation in Kcnq1.

126 Furthermore, we found that common deletion mutation in mtDNA was more prevalent in distal

127 identified increased levels of mtDNA common deletion mutation in postmortem sural nerves of patients

128 equences for a recurrent autosomal-recessive deletion mutation in revealing the genetic basis of SPG2

129 m mice lacking RGS11 (RGS11(-/-)), or with a deletion mutation in RGS7 (RGS7(Delta/Delta)), or both,

130 We constructed an in-frame deletion mutation in rpoN (VP2670) in V. parahaemolyticu

131 Mutant embryonic fibroblasts with the Exon 3 deletion mutation in SHP-2 showed decreased apoptosis an

132 Another line had an 11-bp deletion mutation in the cls gene.

133 A 4-bp deletion mutation in the Distal-Less 3 (DLX3) gene is et

134 Mice with a null deletion mutation in the gamma interferon (IFN-gamma) re

135 of alanine, while a mutant with an in-frame deletion mutation in the gene for alanine racemase lost

136 nts, Six3 protein with a naturally occurring deletion mutation in the helix 3 of the homeodomain does

137 r heterotopia, caused by an unusual in-frame deletion mutation in the meckelin C-terminus at the regi

138 A deletion mutation in the pgn_1932 gene had a significant

139 OSBP deletion mutation in the PH (DeltaPH) domain failed to l

140 We constructed an in-frame deletion mutation in the sagA gene and found that this m

141 (SHIV-Cs), we identified a 3-asparagine (3N) deletion mutation in the V2 loop stem of gp120 as the ma

142 (CEL maturity onset diabetes of youth with a deletion mutation in the VNTR (MODY)).

143 Wild-type spores carrying an insertion-deletion mutation in this cistron germinated normally; t

144 al aging human subjects and identified mtDNA-deletion mutations in all abnormal fibers.

145 ng keratin K6c, showed heterozygous in-frame deletion mutations in all three kindreds.

146 ecutive days, and quantified mtDNA point and deletion mutations in bone marrow and liver using our ne

147 heterozygous missense or in-frame insertion/deletion mutations in C1R (15 families) or C1S (2 famili

148 recently been used to generate insertion and deletion mutations in Caenorhabditis elegans, but not to

149 Yeast strains with deletion mutations in candidate SET domain-containing ge

150 y account for the 4.1-fold increase in mtDNA deletion mutations in DCM (P<0.05 versus nonfailing hear

151 n pathogenesis, we constructed disruption or deletion mutations in each of eight AT-encoding genes an

152 cancer tumours that have EGFR mutations have deletion mutations in exon 19 or the Leu858Arg point mut

153 e most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (

154 Mus81 and Rhp51 are required for generating deletion mutations in fission yeast replication mutants

155 Furthermore, deletion mutations in genes encoding membrane nitrate re

156 bacterium Bacillus subtilis by constructing deletion mutations in genes predicted to be involved in

157 tients with nonsense, frameshift, splice, or deletion mutations in gp91(phox).

158 In this study, we constructed deletion mutations in gspD and gspE, T2SS genes encoding

159 We measured levels of common deletion mutations in mtDNA and expression levels of mit

160 rains, including C57BL/6J, carry nonsense or deletion mutations in Mx1 and thus a nonfunctional allel

161 In addition, we characterized deletion mutations in nonessential genes of unknown func

162 TR2 and TR3 showed deletion mutations in one (wzb) or multiple genes, respe

163 s who had deleterious truncating, splice, or deletion mutations in PALB2.

164 We constructed and characterized in-frame deletion mutations in several FrzS domains to determine

165 glaucoma revealed clustering of missense and deletion mutations in the 5-phosphatase domain and the R

166 S. flexneri strains containing deletion mutations in the entire suf operon (UR011) or t

167 Mutants with in-frame deletion mutations in the genes for alanine dehydrogenas

168 y missense, nonsense, frameshift, splice, or deletion mutations in the genes for p22(phox), p40(phox)

169 on of the successful attenuating capacity of deletion mutations in the guaBA operon in S. flexneri 2a

170 It is caused by deletion mutations in the last exon of the carboxyl este

171 eport the presence of acquired insertion and deletion mutations in the NF-E2 gene in MPN patients.

172 bind HIV-1 gp120, we constructed a series of deletion mutations in the repeat regions of both recepto

173 st neutron (FN) radiation was used to induce deletion mutations in the soybean (Glycine max) genome.

174 We constructed deletion mutations in the usher genes for six of the add

175 g additional examples of previously reported deletion mutations in this region.

176 and six previously reported missense and two deletion mutations in TMEM154.

177 Complementation of the deletion mutations in trans restored drug resistance.

178 DNA sequencing revealed deletion mutations in TTDN1 ranging in size from a singl

179 We examined mtDNA-deletion mutations in vastus lateralis (VL) muscle of hu

180 We introduced nonpolar, defined deletion mutations in waaG (rfaG), waaI (rfaI), rfaH, wa

181 ions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with hi

182 genes were cloned, and chromosomal insertion-deletion mutations inactivating them were obtained to de

183 ases the CaM/Fas binding, and the C-terminal deletion mutation increases the CaM/Fas binding.

184 proliferation assays with N- and C- terminal deletion mutations indicated that the central portion of

185 he pathway (i.e. leu1Delta or leu2Delta gene deletion mutations) induced post-transcriptional up-regu

186 Introduction of the deletion mutation into wild-type gonococci resulted in l

187 n, specifically, a non-temperature-sensitive deletion mutation involving 6 nucleotides in the overlap

188 ith the copresence of complex karyotypes and deletions/mutations involving TP53 demonstrated a partic

189 RNA harboring a complete 3' noncoding region deletion mutation is infectious (not merely quasi-infect

190 In chronic lymphocytic leukemia (CLL), TP53 deletion/mutation is strongly associated with an adverse

191 explored their genetic interactions with 18 deletion mutations known to cause chromosome instability

192 Accordingly, the IEM deletion mutation L955 (DeltaL955) fails to produce resu

193 hat seven nontruncating missense or in-frame deletion mutations (L986F, delF1289, R1648C, F1661S, G16

194 Four discrete insertion/deletion mutations leading to frame shifts and premature

195 of the 5' flanking region by progressive 5' deletion mutations localized transcription repression el

196 breast tumors, there are specific insertion/deletion mutations located close to R-loop-mediated BRCA

197 f these mutations involve either missense or deletion mutations located in a region of the proSP-C mo

198 sed frequency of chromosomal translocations, deletions, mutations, micronuclei, and decreased plating

199 utations at pre-binding sites, insertion and deletion mutations, microsatellite expansions, or tandem

200 nctional effect of overexpression of a 21-bp deletion mutation (mt) of CYTB.

201 Protein 6 with C-terminal deletion mutations no longer interfered with nuclear imp

202 concomitantly reduces the occurrence of "-1 deletion" mutations observed opposite the lesion at lowe

203 identified and characterized a novel exon 27 deletion mutation occurring within the EGFR carboxyl-ter

204 ozygous missense or small in-frame insertion/deletion mutations occurring within one of the helix bou

205 ed to infantile RCM resulting from a de novo deletion mutation of glutamic acid 96.

206 supported by the observation that a nonpolar deletion mutation of htrA did not produce the growth def

207 lls containing intact wild-type genomes or a deletion mutation of the COX2 gene gave rise to populati

208 otide 'TAG' sequences incorporated into each deletion mutation of the yeast knockout collection, allo

209 In-frame deletion mutations of all of the ctp genes, with the exc

210 these genes in pathogenesis, large in-frame deletion mutations of bcaA and bcaB were constructed in

211 ation has negative genetic interactions with deletion mutations of both capping protein subunits and

212 that 18.3% of relapse cases had sequence or deletion mutations of CREBBP, which encodes the transcri

213 viruses and was sensitive to specific glycan deletion mutations of HIV-1 glycoproteins, indicating th

214 ivo function, we generated and characterized deletion mutations of Id2 and of Id4.

215 Deletion mutations of irr and rirA, alone and in combina

216 Point and deletion mutations of Noxa confirmed that both the BH3 d

217 Deletion mutations of PTB in this system allowed us to i

218 Deletion mutations of retromer subunits cause ALM and PL

219 Using a series of deletion mutations of TBX5, we narrowed down its functio

220 Precise null deletion mutations of the mshA gene were generated by sp

221 ial myosin-II heavy-chain gene (myo2-E1) and deletion mutations of the other myosin heavy-chain genes

222 The rate of insertion and deletion mutations of the replicase of Cucumber mosaic v

223 iver and tumour tissue revealed insertion or deletion mutations of the tumour suppressor genes, inclu

224 We constructed deletion mutations of these genes in the F. tularensis l

225 Analogous single-gene deletion mutations of these genes showed significantly s

226 Mutants with in-frame deletion mutations of two of the genes identified from t

227 s, we constructed and characterized nonpolar deletion mutations of virB1 and virB2.

228 purified, and assayed a series of N-terminal deletion mutations of VP30 for RNA binding.

229 With one exception, deletion/mutation of a single terminal nucleotide in one

230 tightly linked to deletion of DDX3Y and that deletions/mutations of USP9Y can be transmitted from one

231 on immunogenicity and the efficacy of a sopB deletion mutation on two Salmonella enterica serovar Typ

232 f the cadherin point mutation W2A and domain deletion mutations on C-cadherin binding signatures.

233 t genes, permitting an extensive analysis of deletion mutations on protein function.

234 cterizing the effects of VirB6 insertion and deletion mutations on substrate translocation identified

235 t is underexpressed in many cancers owing to deletions, mutations or gene silencing.

236 functions in a virus-specific mode, and its deletion, mutation, or replacement by the same subdomain

237 We find an absence of PTEN deletions, mutations, or protein mislocalization in PEL.

238 seudogene decay, which involves an excess of deletion mutations over insertions.

239 in mouse embryos, including indel (insertion/deletion) mutations, point mutations, large deletions, a

240 y identified 2 patients with novel insertion/deletion mutations predicted to result in mRNA nonsense-

241 (64%) of mutations, whereas short insertion-deletion mutations predominated (56%) in the high-transc

242 and X2392S (rs150529054) and a large exon 3 deletion mutation, Q2053del224.

243 letion mutations and no insertions, giving a deletion mutation rate of 1.2 x 10(-9) (95% confidence i

244 Deletion mutation rates were different for the two hosts

245 satory functions for the 3' noncoding region deletion mutation replication defect.

246 ice with a mutation that resembles the large deletion mutation reported in patients.

247 ration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss of 51 carboxy-te

248 reaction driven by dithiothreitol, the 43-51 deletion mutation retained 85% and C43A/C51A 112% of the

249 ype that results from the p.epsilonDeltaF266 deletion mutation revealed by the coinheritance of the l

250 Serial deletion mutations revealed a Dex-responsive 7-base pair

251 Embryonic stem cells with the SHP-2 deletion mutation showed markedly decreased sensitivity

252 ptional activity mediated by the PR NTD, and deletion mutations showed that a region (amino acids 327

253 A pspA deletion mutation significantly attenuates the virulence

254 as an increase in order parameters close to deletion mutation sites, but these can be rationalized i

255 nstable conformation, whereas the C-terminal deletion mutation stabilized the Fas conformation, and b

256 Deletion/mutation studies further show that a 26-bp prom

257 ere further grouped as deletion or insertion-deletion mutations, substitution mutations, insertion or

258 te the properties of this subdomain, a small deletion mutation (targeting aspartic acid 346 and glyci

259 fication had significantly more EGFR exon 19 deletion mutations than adenocarcinomas with disomy, and

260 However, an alternative comD deletion mutation that caused an increase in comE transc

261 We have generated a deletion mutation that eliminates 10 of the 12 viral miR

262 Site-specific deletion mutations that resulted in either aflagellate,

263 SCH9 overexpression or PPH22 deletion, mutations that activate target of rapamycin (T

264 After identifying an insertion-deletion mutation, the remaining 92 families were screen

265 utations were identified, including two 2-bp-deletion mutations, the first non-nonsense mutations ide

266 Here we took advantage of this deletion mutation to understand the role of the S6 helix

267 vivo was investigated by combining in-frame deletion mutations to generate all possible double, trip

268 e sites could allow single base insertion or deletion mutations to occur, and stringent DNA groove mo

269 Previous studies had utilized insertion and deletion mutations to show that portions of the MLD are

270 These deletion mutation transcripts displayed a severe delay i

271 al sequences present in the in vitro-derived deletion mutation transcripts.

272 n induces an especially high frequency of -2 deletion mutations; vulnerability to these mutations is

273 The in-frame deletion mutation was found to be inherited from the mot

274 An sll1951 deletion mutation was introduced into Synechocystis and

275 er number of microsatellite expansion versus deletion mutations was observed, and expansion rates of

276 Based on the effects of a deletion mutation, we suggest that alpha-helix E in Spo0

277 By deletion mutations, we identified the Nt regions importa

278 One MLH1 and one MSH2 deletion mutation were found in MSI-stable/low cases, in

279 ological role of LdTyrRS in Leishmania, gene deletion mutations were attempted via targeted gene repl

280 ysiological role of ASNA in Leishmania, gene deletion mutations were attempted via targeted gene repl

281 Deletion mutations were clonal within a fiber and concom

282 Deletion mutations were constructed in six genes of the

283 addition, compound heterozygous missense and deletion mutations were found in three additional unrela

284 Insertion-deletion mutations were generated in motB and fliI, whic

285 Repetitive-element-mediated deletion mutations were highly conserved within the spec

286 Here, a series of SLK19 in-frame deletion mutations were used to test whether Slk19p has

287 ound in high CRLF2 expressors, whereas IKZF1 deletions/mutations were distributed across the full coh

288 ght independent alleles, with frameshift and deletion mutations) were created in C3H and C57BL/6J bac

289 ingle nucleotide polymorphisms and insertion/deletion mutations when our Weiss (n = 4) and Nigg (n =

290 ique to a given line, except for a single-nt deletion mutation which occurred independently in two li

291 ll five probands with familial disease had a deletion mutation within the closely linked STX16 gene a

292 Each gene has a coding sequence insertion/deletion mutation within the SC species that produces a

293 We recovered a 15 bp deletion mutation within this enhancer that identified a

294 Using minigenes carrying deletion mutations within intron 11, we demonstrated tha

295 t contained frameshift, point, insertion, or deletion mutations within rdxA, possibly revealing genet

296 Recently, the V170D and the G54-P57 deletion mutations within the CAP1/Prss8 gene, identifie

297 Several deletion mutations within the pstSCAB-phoU operon were t

298 We report that deletion mutations within the S4-S5 linker (amino acids

299 made a collection of truncation and in-frame deletion mutations within the VP1/2 gene (UL36) and exam

300 Only five deletion mutations yielded lethal phenotypes, and these