ライフサイエンスコーパス: deletion variant

1 ar mixture of a hydroxylated peptide and the deletion variant.

2 eletion versus the 322 to 325 wild-type (Wt)/deletion variant.

3 healthy humans were genotyped for the ADRA2B deletion variant.

4 nt sequences and lengths, as well as histone deletion variants.

5 -nucleotide polymorphisms and four insertion/deletion variants.

6 rroborated the findings from the analysis of deletion variants.

7 er of the intergenic spacer in each of these deletion variants.

8 a few preferred genotypes among the isolated deletion variants.

9 istinct patterns of SDVs, including 5 double-deletion variants.

10 iants (99%-100%) but low for small insertion/deletion variants (53%-59%).

11 We identified 541 deletion variants (94% novel) ranging from 1 kb to 745 k

12 um to characterize and catalogue segregating deletion variants across the human genome.

13 Except for the last deletion variant, all other variants were unable to comp

14 le, but not among homozygote carriers of the deletion variant allele (0.99; 95% CI: 0.78, 1.27; P for

15 the [4Fe-4S] cluster of both the Fe protein deletion variant and the native Fe protein in the presen

16 The LMP1 deletion variant and the wild-type sequence were also id

17 e donor showed the presence of both the LMP1 deletion variant and the wild-type sequence.

18 Membrane flotation gradient analysis of 1a deletion variants and 1a segments fused to green fluores

19 ing to generate a series of Hunchback domain deletion variants and assay their function during neurog

20 wide patterns of nucleotide polymorphism and deletion variants, and measured the extent of linkage di

21 assembled using different RCC1 homologs and deletion variants, and nucleosomes containing nucleosoma

22 at the IL2 and IL4 loci along with insertion/deletion variants at the IL12B locus (P =.003-.01).

23 the high resolution coordinates of a U2AF65 deletion variant bound to RNA.

24 We constructed a C2 domain deletion variant (C2Delta) and a GR deletion variant (GR

25 sly detect, distinguish, and quantitate exon deletion variant copy numbers of ER.

26 The K(d)(tRNA) value for a loop deletion variant, Delta(227-234), is similar to that for

27 C-Terminal deletion variants (Delta10, Delta20, and Delta33 amino a

28 gment in fibrillization of PrP23-144 using a deletion variant, Delta113-120 PrP23-144, in which the p

29 ng purified full-length Tnp and a C-terminal deletion variant (delta369) that lacks the putative dime

30 The functional loop deletion variant demonstrated less backtracking than in

31 e report mutations of Klentaq (an N-terminal deletion variant) DNA polymerase that have markedly redu

32 Here we use a P5abc deletion variant E(deltaP5abc) to systematically probe t

33 s that phosphacan binding is retained in all deletion variants except those lacking the fibrinogen-li

34 iers compared with noncarriers of the ADRA2B deletion variant exhibited a significantly reduced bias

35 Antisera against the mobile loop deletion variants exhibited increased cross-reactivity,

36 ctivities remaining in D1R carboxyl-terminal deletion variants expressed in Escherichia coli BL21(DE3

37 ce in GFP, a series of N- and C-terminal GFP deletion variant expression vectors were created using t

38 we generated and analyzed IL-6R stalk region deletion variants for cleavability and biological activi

39 causal variant was identified: an insertion-deletion variant, GCTGT-->A (in which A is the risk alle

40 2 domain deletion variant (C2Delta) and a GR deletion variant (GRDelta) of Psd2p and examined their e

41 ll-length copies, a large number of internal deletion variants have been identified.

42 Analysis of three further N-terminal deletion variants, HlyDDelta26, HlyDDelta26-45 and HlyDD

43 s well as transiently expressed sgB4 and its deletion variants; (ii) induction of viral replication i

44 h factors receptor (EGFR) is mutated, as the deletion variant III, resulting in the truncated transcr

45 Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv st

46 A previously reported 30bp deletion variant in the carboxyl terminal of LMP1 gene w

47 wth advantage of B cells expressing the LMP1 deletion variant in the immunocompromised host.

48 The locations and properties of common deletion variants in the human genome are largely unknow

49 e of generating and potentially accumulating deletion variants in the persisting viral RNA population

50 2.4 A crystal structure of the beta hairpin deletion variant incorporating an A opposite a templatin

51 sm spectra and chemical cross-linking of the deletion variants indicate that the secondary and quater

52 ys and Chang cell infection assays with OpaA deletion variants indicated that hypervariable region 1

53 The K(i) value for ANG with the deletion variant is 1.1 fM, only 2-fold higher than with

54 ion is completely suppressed in the starting deletion variant lacking the 3' end of the gene.

55 GFP deletion variants lacking fluorescent activity showed no

56 The 30-bp deletion variant (LMP-1-del) was present in 66% of patie

57 ally occurring carboxy terminal 30 base pair deletion variant LMP1-del were transfected into the cell

58 bsorption spectra of full-length GFP and GFP deletion variants missing the chromophore substrate doma

59 investigated recombinant BM 06.022 (a domain-deletion variant mutant from Escherichia coli comprising

60 By PCR, a deletion variant (NBCn1-E) that lacks 123 amino acids in

61 A genetically engineered deletion variant of D. hafniense PPase lacking the regul

62 ice site variant, a 30-bp in-frame insertion/deletion variant of exon 6 that alters a proline-, gluta

63 etics, CDelta4 (a 4-residue carboxy-terminal deletion variant of FynSH3) appears to be largely unfold

64 A deletion variant of Gas6 containing just the G domain re

65 93 cells transfected with the amino terminal deletion variant of LMP1 or the lytic form of LMP1, know

66 A deletion variant of mouse VPAC2 has been identified in i

67 ics (MD) simulations of wild type and an NTR deletion variant of RecU, with and without HJ.

68 ined whether BOLD activity associated with a deletion variant of the ADRA2b gene coding for the alpha

69 A deletion variant of the dengue virus (DENV) serotype 2 (

70 Here we hypothesized that a functional deletion variant of the gene encoding the alpha2b-adreno

71 The glycoprotein-deletion variant of the SAD-B19 vaccine strain rabies vi

72 These results demonstrate that novel deletion variants of ClC-2 due to partial exon 15 skippi

73 s were not required for receptor binding, as deletion variants of Gas6 which lacked these domains bou

74 an important mechanism for generating viral deletion variants of murine coronavirus.

75 Evidence for mobility of internal deletion variants of other insertion sequences in these

76 Alzheimer's disease-linked and experimental deletion variants of PS1.

77 Kinase-defective point and deletion variants of RIP2 also significantly blocked the

78 A library of random internal deletion variants of S. typhimurium flagellin was constr

79 ty of different SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated th

80 ssembly assays performed between a series of deletion variants of sgB4 and wild-type (wt) CP subunits

81 C6 glioma cells adhere to and spread on deletion variants of tenascin-C containing only the epid

82 confirmed by in vitro binding assays, using deletion variants of the C-terminal half of Cbl with and

83 arious specific locations in full-length and deletion variants of the homodimeric Escherichia coli ri

84 the frequency of malignancy-associated 30-bp deletion variants of the latent membrane protein 1 (LMP-

85 Using site-directed mutagenesis and deletion variants of the murine and human IL-23R, we sho

86 rmed between HIV-1 and FIV integrases and of deletion variants of the two wild-type integrases.

87 Intracellular deletion variants of TLR2 lacking C-terminal 13 or 141 a

88 Using a set of deletion variants of tPA and pharmacological approaches,

89 ureG-1 mutant of Arabidopsis with N-terminal deletion variants of UreG demonstrated that the hypervar

90 addition to successfully detecting the known deletion variants on major histocompatibility complex, w

91 The variant type (the 30-bp deletion variant or nondeleted wild type) of LMP1 gene w

92 by comparing the absorption spectrum of GFP deletion variants over the 300-500-nm range to the absor

93 ing its naturally occurring carboxy terminal deletion variant promote the formation of multinuclear c

94 ture of a nitrogenase Fe protein single site deletion variant reveals a distinctly new conformation o

95 20 persistently infected mice harbored spike deletion variants (SDVs), indicating that deletions are

96 y detection of a viral quasispecies of spike deletion variants (SDVs).

97 In addition, the deletion variant showed a more stable incorporation of a

98 ated that, whereas noncarriers of the ADRA2B deletion variant showed increased functional connectivit

99 Fractionation analysis of p29 deletion variants showed that sequences in the C termina

100 g enrichment of very low-frequency insertion/deletion variants, so far under-investigated, which migh

101 espite removal of the DPYSP(OH)S motifs, the deletion variant still displayed Ara h 2 conformational

102 these recombination events were eliminated, deletion variants still arose with the same kinetics upo

103 The crystal structure of a Bcl-xL deletion variant-TCTP11-31 complex reveals that TCTP ref

104 A human presenilin 1 deletion variant that fails to be proteolytically proces

105 hages worsens atherosclerosis in mice, and a deletion variant that lowers IRF2BP2 expression predispo

106 ynthesis of HBV RC DNA by analyzing a set of deletion variants that collectively represent most of th

107 94 controls to detect excess homozygosity or deletion variants that influence susceptibility.

108 Among the deletion variants that retain the ability to associate w

109 FliK deletion variants that retain the ability to measure hoo

110 is report indicate that the ratios of exon 7 deletion variant to wild type in the tumor tissues are s

111 To analyze the effects of the UGT2B17 gene deletion variant (UGT2B17*2) on SAHA glucuronidation phe

112 sion of human VPAC1 and VPAC2, wild-type and deletion-variant VPAC2 bound the same amount of 125I-VIP

113 Unlike wild-type VPAC2, however, deletion-variant VPAC2 did not transduce VIP-elicited in

114 splayed peptide libraries, and S1 truncation/deletion variants was unable to more precisely define th

115 oximal to the TMDs, the vast majority of the deletion variants were functional.

116 This single base pair insertion/deletion variant, which results in a run of either 5 or

117 n connectivity was absent in carriers of the deletion variant, who instead showed overall enhanced co

118 Nonsynonymous, splice-site, insertion, and deletion variants with an estimated population frequency

119 e obtained for 10,641,224 SNPs and insertion-deletion variants with minor allele frequencies >1% and

120 om carriers of the protective haplotype of a deletion variant within the 3' untranslated region of th

121 and two other in-frame nucleotide insertion/deletion variants within complementarity-determining reg

122 Here, we analyse chimeras and deletion variants within the recombinase C-terminal doma