ライフサイエンスコーパス: deletional

1 ong- standing model that U-insertional and U-deletional activities are separated within the editing c

2 RBCs are distinctly overhydrated relative to deletional alpha-thalassemia variants, and the derangeme

3 erations we analyzed membranes from HbCS and deletional alpha-thalassemic variants and found that in

4 Deletional analyses localized the residues comprising th

5 Deletional analyses of hVps35 demonstrate that amino aci

6 Deletional analyses of the Npr1 promoter along with ecto

7 Deletional analyses of the proximal promoter and the ent

8 Deletional analyses reveal that for each element multipl

9 Progressive deletional analyses together with site-specific mutagene

10 Deletional analyses using heterologous promoter construc

11 o characterize the Xic further, we performed deletional analysis across the 450-kb region by yeast-ar

12 Deletional analysis also suggested that the entire C-ter

13 Reporter gene deletional analysis and EMSAs indicate an IL-2-regulated

14 Deletional analysis and reporter expression assays ident

15 y dependent on the C1 domain, as revealed by deletional analysis and site-directed mutagenesis.

16 An OSM response element was mapped by deletional analysis between base pairs (bp) -148 and -10

17 Deletional analysis carried out in the absence of the c-

18 Deletional analysis confirmed that some of these novel s

19 Deletional analysis confirmed that specific sequences wi

20 Additionally, deletional analysis demonstrated a significant IS contri

21 A comparative deletional analysis demonstrated that a shorter region e

22 The results of the deletional analysis demonstrated that constructs capable

23 Deletional analysis demonstrated that residues present w

24 Deletional analysis demonstrated that the -1098 to -93 r

25 A comprehensive deletional analysis established two regions rich in Sp1

26 tween the two proteins were characterized by deletional analysis in both yeast two-hybrid and gel shi

27 Deletional analysis in human CETP transgenic mice locali

28 Deletional analysis localized a major regulatory region

29 Deletional analysis localized the mSin3A-interacting dom

30 We have performed a detailed deletional analysis of DNA ligase IV to define its XRCC4

31 Deletional analysis of human pIgR revealed that the lack

32 ized to endosomal and vacuolar membranes and deletional analysis of Pib1p domains indicated that loca

33 Data from comparative structural and deletional analysis of PTB are consistent with the prese

34 Initial deletional analysis of the CbpA protein in strain D39 (c

35 Deletional analysis of the EMX2 5' regulatory region rev

36 Deletional analysis of the enhancer identified several s

37 Deletional analysis of the hAhR transactivation domain i

38 Deletional analysis of the human homologue of Skn-1a wit

39 To identify the minimal sequence, a deletional analysis of the late region was performed by

40 Deletional analysis of the murine 5'-flanking region rev

41 Deletional analysis of the promoter indicated that a pro

42 5' deletional analysis of the promoter indicated that the r

43 Deletional analysis of the Q-rich subdomain identified a

44 Fine deletional analysis of this region revealed that a four-

45 Deletional analysis revealed several consensus sequences

46 Deletional analysis revealed that a minimal sequence of

47 Finally, bidirectional deletional analysis revealed that multiple elements are

48 A deletional analysis revealed that the C1 domain in chima

49 Deletional analysis reveals that an AP-1-binding site (5

50 Further deletional analysis showed that a 220-bp region of the h

51 Deletional analysis showed that ADA3 directly associates

52 Additional deletional analysis showed that the SH3 domain was not r

53 In addition, deletional analysis suggested that a core 91-residue seq

54 We demonstrated by deletional analysis that Rad-50/Mre-11 and Ku86 were rec

55 Deletional analysis using epitope-tagged VGF suggested t

56 Deletional analysis was used to generate a beta-catenin

57 582 and amino acids 775-826) were defined by deletional analysis, each of which could act independent

58 Deletional analysis, using both in vitro protocols and c

59 Using deletional analysis, we confirmed that inhibitory activi

60 Using deletional analysis, we have identified in the carboxyl-

61 determine the CbpA-binding motif on pIgR by deletional analysis.

62 Further deletional and alanine mutagenesis analyses and comparis

63 In the present study, we have utilized deletional and alanine substitution mutagenesis within t

64 y NT by using fibroblasts that had undergone deletional and crossover/gene conversion events, respect

65 Deletional and GAL4-fusion gene analyses now reveal repr

66 In this model, both deletional and immunoregulatory mechanisms are active du

67 alleles remain partially functional for both deletional and inversional recombination and can hence e

68 Deletional and mutational analyses identified that Plk1

69 Deletional and mutational analyses indicated that the pu

70 ranscriptional activator for CYP7A1, we used deletional and mutational analyses of CYP7A1 promoter se

71 Using deletional and mutational analysis of the cyclin A promo

72 Deletional and mutational studies revealed that C/EBP bi

73 Based on deletional and mutational studies, the sequence selectiv

74 elopment of immunological tolerance via both deletional and regulatory mechanisms further adds to thi

75 To address this issue, we used deletional and site-directed mutagenesis approaches to s

76 Deletional and site-directed mutagenesis localized the h

77 Deletional and site-directed mutagenesis revealed the pr

78 In this study, we used deletional and site-directed mutagenesis to identify por

79 the activity of RpCAT in response to Rta by deletional and site-directed mutagenesis.

80 tes in the M(3)-MR i3 loop via a strategy of deletional and site-directed mutagenesis.

81 l basis of their heterotypic interactions by deletional and site-specific mutagenesis.

82 Serial deletional and targeted mutational analysis of cis-eleme

83 TbMP18 is critical for the U-deletional and U-insertional cleavages and for integrity

84 Both U-deletional and U-insertional cleavages are reasonably ac

85 anism of inhibition was not dependent upon a deletional, apoptotic pathway, but it was reversed by an

86 es in gamma-globin levels seen in some human deletional beta-thalassemias and hereditary persistence

87 Here we discuss the evidence showing that deletional bias is a major force that shapes bacterial g

88 on--above a maximum threshold--will engage a deletional checkpoint for removal of self-reactive B cel

89 e-B cell receptor signaling, which engaged a deletional checkpoint for the removal of autoreactive B

90 y interconverted editing sites reveal that U-deletional cleavage is inefficient without and activated

91 Analysis of various 3'alpha E deletional constructs indicates that sequences flanking

92 By utilizing a series of mutational and deletional constructs of LDLR promoter luciferase report

93 Transient transfection assays of a series of deletional constructs show that the first hNET intron co

94 Deletional constructs were expressed in IMR32 cells.

95 er, the mechanism by which 53BP1 facilitates deletional CSR and inhibits inversional switching events

96 ation for the link with 53BP1 enforcement of deletional CSR.

97 Interestingly, the thymic deletional effect of sHEL was superior to that of mHEL i

98 Ku80-dependent NHEJ repair, thus preventing deletional end-joining of chromosomal DSBs during G1.

99 J-mediated DSB repair and prevents mutagenic deletional end-joining through interaction with canonica

100 egions and functions via an intrachromosomal deletional event between the donor Smicro region and a d

101 ne segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same

102 rearrangement generates more diversity than deletional events, and (c) fine differences exist in the

103 Through deletional experiments, we showed that the inhibitor of

104 Mice deletional for either MCP-1 or CCR2 had suppressed cell-

105 clude that Th2 cells do not undergo an early deletional form of tolerance after PIT.

106 rames, implicated in the HPFH-1/2 and HPFH-6 deletional forms of the human syndrome, hereditary persi

107 A series of deletional fusion proteins of triadin 1 was generated, a

108 Among the patients with deletional hemoglobin H disease, 15% had one or both par

109 Both noncrossover and deletional homologous repair products are detected, at a

110 carrying an exact beta locus replicate of a deletional HPFH mutation, HPFH 2.

111 n (Apc(Min/+)) mouse model, as mutational or deletional inactivation of APC is a frequent early event

112 Deletional inactivation of the gene encoding d-serine de

113 With deletional, insertional and alanine-scanning mutagenesis

114 T cells transit through a CD8lowV beta 5low deletional intermediate during tolerance induction by a

115 5+ T cells transit through a CD8lowVbeta5low deletional intermediate during tolerance induction.

116 Transient transfection studies using deletional M-CSF promoter constructs demonstrated that T

117 is of these results, we performed a detailed deletional map and identified two distinct regions of de

118 A refined deletional map for 15 VH gene families and an individual

119 ontaining this gene, we performed fine-scale deletional mapping of chromosome 6q in 22 acute/lymphoma

120 a putative tumor suppressor gene may reside, deletional mapping was performed using 33 microsatellite

121 bodies were detectable, suggesting a central deletional mechanism for tolerance.

122 ic tolerance is due mainly to an intrathymic deletional mechanism in these mixed chimeras.

123 Consistent with a requirement for a deletional mechanism in this IL-2Rbeta(-/-) model, a sma

124 e of single-strand annealing, an error-prone deletional mechanism of DSB repair.

125 ance is achieved primarily through a central deletional mechanism when peripheral and intrathymic hos

126 fore, the loss of one copy of PU.1 through a deletional mechanism, plus down-regulation of the residu

127 n of an alloreactive T-cell population via a deletional mechanism.

128 self-reactive T cells that have escaped the deletional mechanisms of central tolerance.

129 e receiving BALB/c hearts is not mediated by deletional mechanisms, but by peripheral regulatory mech

130 fic tolerance through peripheral and central deletional mechanisms.

131 cell repertoire in chimeras indicates T-cell deletional mechanisms.

132 Furthermore, CD154 deletional mice irradiated with 200 cGy irradiation were

133 deletional mice, while IL-4 was absent from deletional mice, but up-regulated in controls.

134 s severity was found in MOG(35-55)-fed MCP-1 deletional mice, indicating induction of oral tolerance.

135 F-beta was up-regulated in fed and immunized deletional mice, while IL-4 was absent from deletional m

136 Deletional mutagenesis also indicate a biological role f

137 variant, we constructed C2delta(17) cDNA by deletional mutagenesis and expressed it transiently in C

138 Deletional mutagenesis localized these residues to a str

139 Deletional mutagenesis maps the RNA sequence causing agg

140 Deletional mutagenesis of individual SRE-like sequences

141 Deletional mutagenesis of the cytoplasmic domain of CD12

142 Deletional mutagenesis shows that the C-terminal 78 amin

143 PhoA fusions, deletional mutagenesis, and N-terminal amino acid sequen

144 By deletional mutagenesis, we found that deleting up to fou

145 Second, CTLA-4 deletional mutant (-/-) bone marrow chimeras were used a

146 L-60/Bcl-xLdelta cells that express the loop-deletional mutant cDNA constructs p19Bcl-2delta32-80 and

147 train of S. cerevisiae, human Prk, but not a deletional mutant protein, fully rescues the temperature

148 stably expressed the c-Jun dominant-negative deletional mutant TAM67, which lacks the NH(2)-terminal

149 amino acid residues in these two regions and deletional mutants missing residues 84-86 and 84-90 impl

150 Deletional mutants of HSPDE4B2B, which have been shown t

151 inducible cis-acting DNA elements, nested 5' deletional mutants of the icIL-1Ra promoter were constru

152 erminants of these differences, chimeric and deletional mutants of the N-terminal domain and the F re

153 Analysis of 7-19 amino acid deletional mutants that spanned the "regulatory module"

154 sicles of A549 cells while all COOH-terminal deletional mutants were restricted to an endoplasmic ret

155 Deletional mutation analysis confirmed that this locus i

156 chain using site-directed mutagenesis and/or deletional mutation.

157 Deletional mutations of HSL localized the region of HSL

158 Deletional mutations show that HSL interacts with the N-

159 crohomology and can join ends precisely; and deletional NHEJ (D-NHEJ), which utilizes microhomology t

160 Transgenic Xenopus laevis were created with deletional or mutated promoter fragments driving an enha

161 The editing can be insertional, deletional, or substitutional and has been found in all

162 t CSR is programmed to occur in a productive deletional orientation and does so via an unprecedented

163 Productive CSR must occur in a deletional orientation by joining the upstream end of an

164 the editing complex than the corresponding U deletional portion.

165 bination (CSR) occurs by an intrachromosomal deletional process between switch (S) regions in B cells

166 ccurs by a B cell-specific, intrachromosomal deletional process between switch regions.

167 In addition, the actual deletional process in thymi of the double-Tg mice was vi

168 sting that an immunoregulatory rather than a deletional process underlies this operational tolerance

169 y, we present the first analytical model for deletional rearrangement and show that it is consistent

170 i-CD152 (anti-CTLA-4) mAb or the use of CD28 deletional recipients abrogated engraftment in anti-CD15

171 Class switching occurs by a deletional recombination between two switch regions, eac

172 eavy (H) chain class switch is mediated by a deletional recombination event between micro and gamma,

173 ive switch (S) regions, with CSR involving a deletional recombination event between the donor Smu reg

174 occurs by a unique type of intrachromosomal deletional recombination within special G-rich tandem re

175 CSR generally occurs by an intrachromosomal deletional recombination within switch (S) region sequen

176 ype switch, where RNA processing may precede deletional recombination.

177 ocytes, and that it induces antigen-specific deletional responses in CD4(+) and CD8(+) T cells.

178 her and from previously characterized (early deletional) responses of naive CD4(+) T cells to PIT.

179 ival of transferred T-cells despite powerful deletional signals that mediate Bim (BCL2L11)-dependent

180 id structures, which target nucleases in for deletional switch recombination.

181 to clinical use for the induction of central deletional T-cell tolerance.

182 However, the relative frequency of deletional to inversional CSR junctions has not been mea

183 medullary epithelial cells (MECs) to mediate deletional tolerance and thereby prevent autoimmunity.

184 del for the induction of mixed chimerism and deletional tolerance and thus further decreases the toxi

185 arrier for establishing chimerism, implicate deletional tolerance as the mechanism for total body irr

186 response to soluble Ags generally results in deletional tolerance following transient, costimulation-

187 s, but the role of CD28 in peripheral T cell deletional tolerance has not been investigated.

188 tigens that are not prominently presented in deletional tolerance likewise retain a high relative imm

189 Vbeta analysis suggested a central deletional tolerance mechanism.

190 ells are much less influenced by central and deletional tolerance mechanisms, and instead display a p

191 dendritic cells in a pathway culminating in deletional tolerance of peripheral alloreactive CD8 cell

192 , escape of retrovirus-specific B cells from deletional tolerance offers the opportunity to induce pr

193 Non-deletional tolerance resulting in the generation of regu

194 cell engraftment, a robust state of central deletional tolerance to allogeneic or xenogeneic donors

195 onses to liver-expressed antigens range from deletional tolerance to full effector differentiation re

196 we investigate a role for the Fas pathway in deletional tolerance to high dose bone marrow.

197 omal cells (LNSC) are important mediators of deletional tolerance to peripheral tissue-restricted ant

198 Evidence for deletional tolerance was obtained in mixed chimeras prep

199 by 3-Gy WBI allows the induction of central deletional tolerance while minimizing the toxicity of th

200 tant role for the thymus not only in central deletional tolerance, but also in the induction of perip

201 chimerism such protocols can permit central deletional tolerance, but with a significant risk of gra

202 n and suggest that in the absence of central deletional tolerance, peripheral tolerance mechanisms ar

203 typically not presented during induction of deletional tolerance, retain a high degree of relative i

204 Unlike deletional tolerance, Treg cell-mediated tolerance was b

205 pheral tissue antigens and induce CD8 T-cell deletional tolerance.

206 patibility complex antigen to further assess deletional tolerance.

207 a CD4 T-cell response, indicating a lack of deletional tolerance.

208 finity tilted our system in the direction of deletional tolerance.

209 lopment of mixed hematopoietic chimerism and deletional tolerance.

210 syngeneic BMC, results in part from durable deletional unresponsiveness of graft-specific alloreacti

211 Transient transfection of deletional VCAM-1 promoter constructs and electrophoreti