ライフサイエンスコーパス: delirium

1 r scheduled noncardiac surgery (N = 566; 24% delirium).

2 m episodes were characterized as hyperactive delirium.

3 prove recognition and risk stratification of delirium.

4 pathologic processes specifically relate to delirium.

5 a positive correlation with the severity of delirium.

6 are potential pathophysiologic mechanisms of delirium.

7 xmedetomidine does not prevent postoperative delirium.

8 were associated with greater odds of having delirium.

9 anti-inflammatory properties it might reduce delirium.

10 s were women and 24% developed postoperative delirium.

11 iming when administering the drug to prevent delirium.

12 to delirium, yet its management differs from delirium.

13 sociation between the identified protein and delirium.

14 mary study outcome measure was prevalence of delirium.

15 nsor imaging abnormalities and postoperative delirium.

16 should validate their use in protection from delirium.

17 ne administration would reduce postoperative delirium.

18 by baseline education level and in-hospital delirium.

19 medical catatonia preclude its diagnosis in delirium.

20 antly associated with a reduced frequency of delirium.

21 lude diagnosing catatonia in the presence of delirium.

22 nits is associated with reduced incidence of delirium.

23 vements differ among individuals who develop delirium.

24 ion of dexmedetomidine reduces postoperative delirium.

25 to be valid and reliable tool for diagnosing delirium.

26 ome evidence suggests that ketamine prevents delirium.

27 emaining subjects, 25% screened positive for delirium, 13% were classified as comatose, and 62% were

28 CI, 1.25-3.34) as was stage 3 injury (OR for delirium, 2.56; 95% CI, 1.57-4.16) (OR for coma, 3.34; 9

29 The 279 individuals with delirium (75% women) had worse initial scores (-2.8 poin

30 to 5 was 100% sensitive and 92% specific to delirium across assessments.

31 s at the population level support a role for delirium acting independently and multiplicatively to th

32 ength of stay was increased in children with delirium (adjusted relative length of stay, 2.3; CI = 2.

33 itical illness are associated with prolonged delirium after biomarker measurement.

34 prevalence, predictors, and consequences of delirium among critically ill Arabic speaking patients.

35 ricted visitation model on the occurrence of delirium among ICU patients.

36 Patients were assessed for delirium and catatonia by independent and masked personn

37 erstand the overlap and relationship between delirium and catatonia in ICU patients and determine dia

38 with improved survival and more days free of delirium and coma after adjusting for age, severity of i

39 Acute kidney injury is a risk factor for delirium and coma during critical illness.

40 ether acute kidney injury is associated with delirium and coma in critically ill adults.

41 thesis that simvastatin modifies duration of delirium and coma in critically ill patients.

42 We assessed patients for delirium and coma twice daily after enrollment using the

43 ents experienced more days alive and free of delirium and coma with both total bundle compliance (inc

44 examined kidney injury as a risk factor for delirium and coma.

45 ury and daily peak serum creatinine and both delirium and coma.

46 ty; the rate of intubation and assessment of delirium and comfort were secondary outcomes.

47 The Prevention of Delirium and Complications Associated with Surgical Trea

48 Secondary outcomes include duration of delirium and ICU length of stay.

49 Considering the high incidence of delirium and its consequences, prevention of delirium is

50 Elder Life Program (mHELP) reduces incident delirium and LOS in older patients undergoing abdominal

51 to determine associations between pediatric delirium and modifiable risk factors such as benzodiazep

52 s linear regression and interactions between delirium and pathologic burden were assessed.

53 terventions for common complications such as delirium and postoperative cognitive dysfunction.

54 d patients experiencing hyperactive or mixed delirium and receiving continuous observation were conse

55 el was associated with reduced occurrence of delirium and shorter length of delirium/coma and ICU sta

56 n was used to assess the association between delirium and symptoms of anxiety, depression, and posttr

57 ween either a single day or multiple days of delirium and symptoms of anxiety, depression, or posttra

58 interventions for patients at high risk for delirium and tailored transitional care planning may hel

59 these variables resulted in individuals with delirium and the pathologic processes of dementia declin

60 However, the combination of delirium and the pathologic processes of dementia result

61 ate of the art in diagnosis and treatment of delirium and to highlight critical areas for future rese

62 The mean number of days alive without delirium and without coma at day 14 did not differ signi

63 with the development and longer duration of delirium, and lower likelihood of ICU discharge.

64 To characterize sedation, analgesia, delirium, and mobilization practices in patients support

65 n important mechanism in the pathogenesis of delirium, and since simvastatin has anti-inflammatory pr

66 Delirium appeared within the first five days after admis

67 itive functions or who develop postoperative delirium are at risk of developing dementia within 5 yea

68 cal ventilation via an endotracheal tube and delirium are important predictors of mobility progressio

69 e nonpharmacological interventions to manage delirium are needed.

70 , the epidemiology and outcomes of pediatric delirium are not well-characterized.

71 mary outcome was the cumulative incidence of delirium, assessed bid using the confusion assessment me

72 gth of ICU stay is less then one day or when delirium assessment is not possible.

73 s were randomized; 390 completed in-hospital delirium assessments (median [interquartile range] age,

74 Daily delirium assessments were completed using the Preschool

75 Delirium at postoperative day 7 was 6.3% for suction-bas

76 nal recovery than their counterparts without delirium; at 1 month, the covariate-adjusted mean differ

77 commendations for pharmacologic treatment of delirium, based on recent reviews of the evidence, recom

78 There was no difference in postoperative delirium between the dexmedetomidine and placebo groups

79 ICU totaling 10,216 visits were screened for delirium by means of the Confusion Assessment Method.

80 um using the Cornell Assessment of Pediatric Delirium by the bedside nurse.

81 accelerate implementation of evidence-based delirium care for people receiving palliative care, both

82 Potential benefits for reduction in delirium, cognition, and symptomatic stroke merit larger

83 ty, baseline cognition, severity of illness, delirium, coma, sepsis, mechanical ventilation, and seda

84 of the UNDERPIN-ICU program on the number of delirium-coma-free days in 28days and several secondary

85 itation model patients had shorter length of delirium/coma (1.5 d [interquartile range, 1.0-3.0] vs 3

86 occurrence of delirium and shorter length of delirium/coma and ICU stay.

87 1) concentrations were associated with fewer delirium/coma-free days after adjusting for age, Charlso

88 ined secondary outcomes included duration of delirium/coma; any ICU-acquired infection; ICU-acquired

89 s (interquartile range, 12.7-60.6) of having delirium compared with patient assessments with zero Dia

90 ty, patients were independently assessed for delirium daily by the research team using the PreSchool

91 272 patients were assessed for delirium daily in intensive care.

92 Delirium defined as a positive Confusion Assessment Meth

93 Participants with delirium demonstrated lesser functional recovery than th

94 Diagnoses of delirium, depression, and dementia were made according t

95 3 patients with advanced cancer and agitated delirium despite scheduled haloperidol from February 11,

96 Seventy-eight percent of children with delirium developed it within the first 3 PICU days.

97 Some in-hospital risk factors for delirium development are modifiable.

98 d ratio, 0.65 [0.42-1.00]; p = 0.01), longer delirium duration (incidence rate ratio, 2.47 [1.36-4.49

99 rier/neurological injury are associated with delirium duration during critical illness.

100 ) concentrations were associated with longer delirium duration in survivors.

101 sing Cox proportional hazards regression and delirium duration using negative binomial regression.

102 2 months (P < 0.001), and longer in-hospital delirium duration was associated with worse global cogni

103 cluded, of whom 27 (47%) were diagnosed with delirium during their ICU stay via DSM-IV criteria.

104 al, medical, or trauma) and at high risk for delirium, E-PRE-DELIRIC >/=35%, will be included, unless

105 other delirium severity measures, its use in delirium efficacy trials, and real-life implementation i

106 atonin agonists have found improved rates of delirium, enhanced sleep, and lower arrhythmia prevalenc

107 ynthesis of a research project investigating delirium epidemiology, systems and nursing practice in p

108 ered five different research questions about delirium epidemiology, systems of care and nursing pract

109 e (46%) and mixed (45%) subtypes; only 8% of delirium episodes were characterized as hyperactive deli

110 eparated them from the overall generation of delirium evidence, and contributed to the extent of prac

111 There are many delirium evidence-practice gaps in palliative care, incl

112 pared with reference standard assessments by delirium experts using the Diagnostic and Statistical Ma

113 needed to determine best practices to limit delirium exposure in at-risk children.

114 The hazard ratio for incident delirium for African Americans in the 18-49 years age gr

115 ge) age of 20 months (11-37 mo), and 44% had delirium for at least 1 day (1-2 d).

116 Of 136 patients, 58 patients (43%) had only delirium, four (3%) had only catatonia, 42 (31%) had bot

117 and outcomes including hospital survival and delirium-free and coma-free days in community hospitals.

118 used) and outcomes of hospital survival and delirium-free and coma-free days, after adjusting for ag

119 was number of days alive and was assessed as delirium-free and coma-free in the first 14 days after b

120 3% were classified as comatose, and 62% were delirium-free and coma-free.

121 e implementation of the pain, agitation, and delirium guidelines using the evidence-based ABCDEF bund

122 l to operationalize the Pain, Agitation, and Delirium guidelines.

123 dle in implementing the Pain, Agitation, and Delirium guidelines.

124 Postoperative delirium had occurred in 87% of those who later develope

125 ive use of dexmedetomidine for prevention of delirium has not been well studied.

126 Although often underrecognized, delirium has serious adverse effects on the individual's

127 est for objectively detecting inattention in delirium, implemented on a custom-built computerized dev

128 management of older people with dementia and delirium in acute hospitals.

129 To determine prevalence of delirium in critically ill children and explore associat

130 this study were to describe the frequency of delirium in critically ill children, its duration, assoc

131 Delirium in critically ill patients is associated with p

132 serve as a biological marker associated with delirium in ESLD patients.

133 Fourteen patients (9.6%) developed delirium in extended visitation model compared with 29 (

134 sociation between statin use and the risk of delirium in hospitalized patients with an admission to t

135 y associated with a reduction in the risk of delirium in hospitalized patients.

136 ing multi component interventions to prevent delirium in ICU patients have also shown beneficial effe

137 he pleiotropic effects of statins can reduce delirium in intensive care and decrease subsequent cogni

138 suggest that the use of statins might reduce delirium in intensive care.

139 a rescue drug for treating agitation due to delirium in nonintubated patients in whom haloperidol ha

140 naesthetic dose of ketamine did not decrease delirium in older adults after major surgery, and might

141 of ketamine for prevention of postoperative delirium in older adults.

142 The Delirium in Palliative Care (DePAC) project was a two-ph

143 -ICU has diagnostic utility in detecting ICU delirium in patients with Richmond Agitation and Sedatio

144 Delirium in the ICU is associated with poor outcomes but

145 nd physical therapy interventions to prevent delirium in the ICU, called UNDERPIN-ICU (nUrsiNg DEliRi

146 al risk for developing incident or prevalent delirium in the ICU.

147 e of benzodiazepines to control agitation in delirium in the last days of life is controversial.

148 Delirium in the presence of the pathologic processes of

149 trial of hospitalized patients with agitated delirium in the setting of advanced cancer, the addition

150 ol for persistent agitation in patients with delirium in the setting of advanced cancer.

151 ogram resulted in a significant reduction of delirium incidence and duration.

152 sor imaging before surgery, on postoperative delirium incidence and severity, as well as the relation

153 There was no difference in delirium incidence between patients in the combined keta

154 days and several secondary outcomes, such as delirium incidence, the number of days of survival in 28

155 independently associated with development of delirium included age less than 2 years, mechanical vent

156 variable analysis, independent predictors of delirium included age less than or equal to 2 years old,

157 using on several modifiable risk factors for delirium, including cognitive impairment, sleep deprivat

158 es of older adults have investigated whether delirium influences the trajectory of functional recover

159 valid/reliable translation of a standardized delirium instrument such as the Confusion Assessment Met

160 Hyperactive or mixed delirium is a common and serious complication experience

161 Delirium is a common and serious postoperative complicat

162 Delirium is a common and serious psychiatric syndrome ca

163 Delirium is a common disorder in Intensive Care Unit (IC

164 Delirium is a common, morbid, and costly postoperative c

165 Delirium is a highly prevalent syndrome of acute brain d

166 Delirium is a postoperative complication that occurs fre

167 Delirium is a prevalent complication of critical illness

168 Delirium is a serious acute neurocognitive condition fre

169 Delirium is associated with a lower likelihood of ICU di

170 Delirium is associated with accelerated cognitive declin

171 Postoperative delirium is associated with increased morbidity, mortali

172 Delirium is common in mechanically ventilated patients a

173 Delirium is defined as an acute disorder of attention an

174 ted at prevention and treatment of pediatric delirium is essential to improve outcomes in this popula

175 delirium and its consequences, prevention of delirium is imperative.

176 accelerated cognitive decline observed after delirium is independent of the pathologic processes of c

177 aking critically ill patients suffering from delirium is limited by the need for a valid/reliable tra

178 Since delirium is more prevalent in older adults, the focus wa

179 Delirium is prevalent among critically ill children, yet

180 t to date, the relationship between race and delirium is unclear.

181 ations; and palliative care nurses had unmet delirium knowledge needs and worked within systems and t

182 The delirium management regimen included timely administrati

183 aimed to identify blood-based postoperative delirium markers in a nested case-control study of older

184 udy in 30 selected patients with and without delirium (median age, 63 yr; range, 23-84) who were asse

185 and Breathing Coordination, Choice of drugs, Delirium monitoring and management, Early mobility, and

186 kidney injury within 30 days after surgery; delirium; mortality; serious adverse events; and neuroco

187 delirium (n = 86; 15%), or multiple days of delirium (n = 211; 37%) during ICU stay.

188 nts were classified as having experienced no delirium (n = 270; 48%), a single day of delirium (n = 8

189 no delirium (n = 270; 48%), a single day of delirium (n = 86; 15%), or multiple days of delirium (n

190 Delirium (never vs ever) and pathologic burden of neurof

191 operidol 1 mg or placebo every 6 hours until delirium occurred (Intensive Care Delirium Screening Che

192 Postoperative delirium occurred in 13 of 196 (6.6%) mHELP participants

193 Postoperative delirium occurred in 29 of 136 subjects (21%) during hos

194 There was a moderate to high rate of delirium occurrence in palliative care unit populations;

195 Delirium occurs frequently in adults and is an independe

196 Delirium occurs frequently in critically ill children an

197 Postoperative delirium occurs in 10% to 60% of elderly patients having

198 2 acute kidney injury was a risk factor for delirium (odds ratio [OR], 1.55; 95% confidence interval

199 d with a significant decrease in the risk of delirium (odds ratio, 0.47; 95% CI, 0.38-0.56).

200 Four studies assessed duration of delirium; of which, three reported a shorter duration of

201 rmination of delirium subtype, and effect of delirium on duration of mechanical ventilation, and leng

202 tudies are required to investigate effect of delirium on long-term outcomes and possible preventive a

203 pite the significant impact of postoperative delirium on surgical outcomes and the long-term prognosi

204 that survivors of critical illness spent in delirium or coma.

205 d cognitive decline beyond that expected for delirium or the pathologic process itself.

206 r baseline) values were also associated with delirium (OR, 1.35; 95% CI, 1.18-1.55) and coma (OR, 1.4

207 54-0.84) and the occurrence of postoperative delirium (p = 0.002; odds ratio, 7.57; 95% CI, 2.15-26.6

208 on for admission to the intensive care unit, delirium, pain, airway status, hours of mechanical venti

209 There are few biological markers of delirium, perhaps related to the etiologic heterogeneity

210 to 40% of patients who develop postoperative delirium (POD) never return to their preoperative cognit

211 associations between daily risk factors and delirium presence the following day.

212 ren who were in the PICU for 6 or more days, delirium prevalence rate was 38%.

213 Delirium prevalence rates varied significantly with reas

214 ion, and sleep deprivation are effective for delirium prevention and also are recommended for deliriu

215 ium in the ICU, called UNDERPIN-ICU (nUrsiNg DEliRium Preventive INterventions in the ICU).

216 The reduction in delirium previously demonstrated in numerous surgical in

217 tients were assessed daily for postoperative delirium (primary outcome) and secondarily for postopera

218 r, leading many to speculate that concurrent delirium, psychiatric disease, dementia, or a second les

219 The prevalent delirium rate was 14% in both African Americans and Cauc

220 with reason for ICU admission, with highest delirium rates found in children admitted with an infect

221 ICU, Richmond Agitation-Sedation Scale, and Delirium Rating Scale-Revised-98 assessments.

222 ch's alpha = 0.85) and good correlation with Delirium Rating Scale-Revised-98 scores (correlation coe

223 dary end points were rescue neuroleptic use, delirium recall, comfort (perceived by caregivers and nu

224 been established for patients with agitated delirium receiving mechanical ventilation.

225 and team processes that were inadequate for delirium recognition and assessment.

226 cant between-group differences were found in delirium-related distress and survival.

227 ber of days of survival in 28 and 90days and delirium-related outcomes.

228 ics were performed to identify the strongest delirium-related protein, which was selected for ELISA v

229 rom the proteomics analysis as the strongest delirium-related protein.

230 le pharmacologic prevention and treatment of delirium remains controversial.

231 moglobin and brain dysfunction (p = 0.69 for delirium), renal dysfunction (p = 0.30), or ICU mortalit

232 Use of a delirium scale was reported by 55% respondents.

233 69.2% for the Pediatric Anesthesia Emergence Delirium scale, 76.9% for the Pediatric Confusion Assess

234 ours until delirium occurred (Intensive Care Delirium Screening Checklist >/= 4 with psychiatric conf

235 be taken into consideration when choosing a delirium screening instrument.

236 Universal delirium screening is practical and can be implemented i

237 idence and the most current understanding of delirium screening practices.

238 Delirium severity in the ICU is not routinely measured b

239 Delirium severity is independently associated with longe

240 Method for the ICU-7 is a valid and reliable delirium severity measure among ICU patients.

241 Further research comparing it to other delirium severity measures, its use in delirium efficacy

242 he Confusion Assessment Method for the ICU-7 delirium severity scale.

243 ss the reliability and validity of a new ICU delirium severity tool, the Confusion Assessment Method

244 egivers and nurses), communication capacity, delirium severity, adverse effects, discharge outcomes,

245 operatively, those who develop postoperative delirium should be followed up to enable early detection

246 atin types in hospitalized patients prone to delirium should validate their use in protection from de

247 care planning, patient request for referral, delirium, spinal cord compression, brain or leptomeninge

248 Test Box-ICU performance was associated with delirium status.

249 maximum of 28 days, irrespective of coma or delirium status.

250 were analysed blind to the clinical data and delirium status.

251 condary objectives included determination of delirium subtype, and effect of delirium on duration of

252 s of C-reactive protein were associated with delirium, suggesting that a preinflammatory state and he

253 These findings suggest that the Edinburgh Delirium Test Box-ICU has diagnostic utility in detectin

254 The Edinburgh Delirium Test Box-ICU has potential additional value in

255 The Edinburgh Delirium Test Box-ICU involves a behavioral assessment a

256 23-84) who were assessed with the Edinburgh Delirium Test Box-ICU on up to 5 separate days.

257 Longitudinally, participants' Edinburgh Delirium Test Box-ICU performance was associated with de

258 An Edinburgh Delirium Test Box-ICU score less than or equal to 5 was

259 Edinburgh Delirium Test Box-ICU scores (range, 0-11) were lower fo

260 custom-built computerized device (Edinburgh Delirium Test Box-ICU).

261 otal PICU costs were higher in patients with delirium than in patients who were never delirious ($18,

262 s (range, 0-11) were lower for patients with delirium than those without at the first (median, 0 vs 9

263 36-4.49]; p = 0.005), and increased risk for delirium the following day (odds ratio, 2.83 [1.27-6.59]

264 one in three patients had both catatonia and delirium, these data prompt reconsideration of Diagnosti

265 rium prevention and also are recommended for delirium treatment.

266 s only greater in patients who progressed to delirium tremens (11.1%; p = 0.02); otherwise, there wer

267 re head injury also predicted progression to delirium tremens (odds ratio, 6.08; p = 0.01), and hypok

268 Alcohol withdrawal syndrome progressed to delirium tremens in 11%.

269 prognosis of alcohol withdrawal syndrome and delirium tremens in patients with traumatic injury.

270 wal syndrome experience a high occurrence of delirium tremens that is associated with significant mor

271 ccurrence of alcohol withdrawal syndrome and delirium tremens, injury characteristics, risk factors f

272 , age, and severe head injury for developing delirium tremens.

273 ssion identified the following predictors of delirium tremens: baseline CIWA-Ar score greater than or

274 Children were screened for delirium twice daily throughout their ICU stay.

275 in limbic and memory functions predispose to delirium under the stress of surgery.

276 Prevention of delirium using nonpharmacologic approaches is documented

277 We assessed delirium using the Confusion Assessment Method for the I

278 ile in hospital for presence and severity of delirium using the Confusion Assessment Method, and thei

279 Children were screened for delirium using the Cornell Assessment of Pediatric Delir

280 sessed patients daily for brain dysfunction (delirium, using Confusion Assessment Method for ICU), fo

281 Mental status (normal vs. delirium vs. coma) was assessed daily with the Confusion

282 Cognitive decline attributable to delirium was -0.37 MMSE points per year (95% CI, -0.60 t

283 The prevalence of delirium was 22.3% in the unmatched cohort and 22.8% in

284 Delirium was a strong and independent predictor of morta

285 Presence of delirium was assessed daily by 2 trained nurses who were

286 Delirium was assessed twice daily in the first 3 postope

287 Presence of delirium was assessed using the Confusion Assessment Met

288 Delirium was associated with persistent and clinically m

289 To investigate if postoperative delirium was associated with the development of dementia

290 PRE-DELIRIC >/=35%, will be included, unless delirium was detected prior ICU admission, expected leng

291 Of 1,547 consecutive patients, delirium was diagnosed in 267 (17%) and lasted a median

292 Delirium was significantly associated with a decreased l

293 The incidence of postoperative delirium was significantly lower in the dexmedetomidine

294 Presence of an endotracheal tube and delirium were negatively associated with out-of-bed mobi

295 Most cases of delirium were of the hypoactive (46%) and mixed (45%) su

296 surgery who received the mHELP, the odds of delirium were reduced by 56% and LOS was reduced by 2 da

297 inal surgery commonly experience preventable delirium, which extends their hospital length of stay (L

298 nurses' capabilities to recognize and assess delirium will require action at the patient and family,

299 which, three reported a shorter duration of delirium with sleep intervention.

300 illness and appear as clinically similar to delirium, yet its management differs from delirium.