ライフサイエンスコーパス: delivery

1 g the T6SS structural machinery for effector delivery.

2 covalent fusion to the protein for efficient delivery.

3 y the application of NPs to therapeutic gene delivery.

4 every week from enrolment to 6 months after delivery.

5 n an ambulance by spontaneous vaginal vertex delivery.

6 roneedles offer an efficient method for drug delivery.

7 and to identify the optimal route of vector delivery.

8 enerative medicine, and cell and therapeutic delivery.

9 ting the need for better skilled care during delivery.

10 it was dependent on antigen formulation and delivery.

11 tate cell biodistribution and survival after delivery.

12 be effective even if given only hours before delivery.

13 eptor required for targeted membrane-protein delivery.

14 onformation during formulation, storage, and delivery.

15 d by intact vs rupture of membranes prior to delivery.

16 vailable therapies and is designed for exact delivery.

17 encapsulate medical agents for enhanced drug delivery.

18 reduced the rate of SSI within 30 days after delivery.

19 t activity and reliance on intracellular DNA delivery.

20 lability by 100% as compared to oral gavage delivery.

21 from ores and nuclear waste, as well as drug delivery.

22 r shifts in vegetation and ecosystem service delivery.

23 udies have mainly utilized direct myocardial delivery.

24 during pregnancy on fetal growth and preterm delivery.

25 have shown critical value in advancing drug delivery.

26 nctions, or involved with drug targeting and delivery.

27 or its introduction into clinical use is its delivery.

28 d is a deterrent to facility utilization for delivery.

29 th readmission was assessed to 7 years after delivery.

30 lowing administration by convection enhanced delivery.

31 0 (95% CI, 1.02-1.65) for 2 or more cesarean deliveries.

32 ivery, and 724 (9.4%) had 2 or more cesarean deliveries.

33 teria, 5267 (68.5%) had no previous cesarean delivery, 1694 (22.0%) had 1 cesarean delivery, and 724

34 Nurse and postal delivery achieved similar 12-mo PA outcomes.

35 s for the creation of more potent biological delivery agents for research and biomedical applications

36 may be useful for the development of future delivery agents with improved properties.

37 Based on equivalent or higher nicotine delivery, an acute exposure to e-cigarette aerosol had a

38 s of 1.16 (95% CI, 0.98-1.37) for 1 cesarean delivery and 1.30 (95% CI, 1.02-1.65) for 2 or more cesa

39 To characterize the kinetics of RNAi trigger delivery and 5-phosphorylation of guide strands correlat

40 ill depend on high rates of HIV testing, ART delivery and adherence, good patient monitoring and supp

41 d signals persist beyond the period of fluid delivery and are generated by neurons within the MFC.

42 d the associations between specific modes of delivery and asthma in children from 9 European birth co

43 ce nanofilms that are better suited for drug delivery and biomedical applications by reducing the pos

44 plication of CM-ALs (10%) scaffolds for drug delivery and bone tissue engineering.

45 o provide better solutions for site-specific delivery and could further facilitate clinical translati

46 erties allow hepatic FcRn to mediate albumin delivery and maintenance in the circulation, but they al

47 ction of biomaterials that are used for drug delivery and multimodal imaging, among others.

48 al implications, including concepts for drug delivery and new classifications and therapeutic options

49 Toxin delivery and nutrient extraction occur in a contact-depe

50 d obesity, with implications for health-care delivery and obesity prevention strategies.

51 but they are better known as tools for gene delivery and oncolytic anticancer therapy.

52 of a wearable patient sensor to improve care delivery and patient outcomes by increasing the total ti

53 tages of oligonucleotide drugs is that their delivery and potency are derived primarily from the chem

54 t toward immunostimulation and improves drug delivery and therapeutic outcomes.

55 t number of applications from energy to drug delivery and to agriculture.

56 ed maternal conditions based on the place of delivery and type of stillbirth.

57 Successful delivery and uptake in cells resulted in altered ATP lev

58 g to PLEKHM1 is required for its function in delivery and, therefore, degradation of endocytic and au

59 sarean delivery, 1694 (22.0%) had 1 cesarean delivery, and 724 (9.4%) had 2 or more cesarean deliveri

60 , small-for-gestational-age births, cesarean delivery, and low Apgar score.

61 g chemical sensing, biological imaging, drug delivery, and photothermal therapy.

62 hagic stroke, and oophorectomy, HDP, preterm delivery, and stillbirth for any stroke.

63 fects of disease, the quality of health-care delivery, and treatment efficacy across various disease

64 development of microneedle devices for drug delivery applications into skin.

65 ors (LMWGs) are promising scaffolds for drug-delivery applications.

66 efficacy of non-viral TUS-based hSef-b gene delivery approach for the treatment of prostate cancer t

67 Protein-based methods of siRNA delivery are capable of uniquely specific targeting, but

68 support DNA-delivered monoclonal antibodies delivery as a potential strategy to augment the host imm

69 ults open the potential for using s.c. islet delivery as a treatment option for type I diabetes, the

70 e associated with increased risks of preterm delivery, asphyxia-related neonatal complications, and c

71 n resulted in a greater (16%) rise in oxygen delivery associated with reduction in oxygen extraction

72 Examining deliveries at each week from 23 through 38, whole-pregna

73 cule level has the potential to impair cargo delivery at locations of microtubule defect sites in viv

74 This review summarizes the delivery barriers for nano-carriers presented in tumor m

75 stantial opportunity to improve radiotherapy delivery beyond just technological and anatomical precis

76 and cord plasma from 259 Caucasian women at delivery (BMI 18-55 kg/m(2)).

77 After delivery by intracerebroventricular injection to ATXN2-Q

78 While chemotherapy delivery by nanocarriers has modestly improved the survi

79 Further, doxorubicin delivery by temperature-sensitive liposomes can reliably

80 Intravaginal drug delivery can elicit a local effect, or deliver drugs sys

81 her day-and-night hybrid closed-loop insulin delivery can improve glucose control while alleviating t

82 emonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio.

83 rage and separations, chemical sensing, drug delivery, catalysis, and nanoscale devices.

84 Convection enhanced delivery (CED) provides a powerful means to bypass the b

85 eactant consumption and facilitates solution delivery close to the SiPM to increase the detection eff

86 n reported a skilled attendant during recent deliveries compared with 381 (3%) of 11 366 women in Rag

87 complications and excessive bleeding during delivery contributed to nearly 30% of the cases as a pos

88 ulmonary tumour models, nanotherapeutic drug delivery correlated with TAM heterogeneity, and successf

89 % of women in Kabul and 47% in Ragh incurred delivery costs (mean US$66.20, IQR $61.30 in Kabul and $

90 The annual market value for successful gene delivery could exceed US$30 billion, and this will encou

91 Nanoparticle (NP)-based pericardial drug delivery could provide a strategy to concentrate therape

92 mains unknown, including RONS speciation and delivery depth, or how plasma-derived RONS intervene in

93 W groups were randomized to 1 of 3 arms: (1) delivery (direct distribution of an oral HIVST from the

94 e been shown to strongly affect nucleic acid delivery efficiency.

95 sensor with optical and microwave waveguide delivery enables thermometry with single-cell resolution

96 nal comparisons is threatened, as is service delivery, especially in Northern Ireland.

97 le clearance from the local tissue 24h after delivery ex vivo.

98 We discuss options for gene delivery experiments to test circuit and behavioral hypo

99 a calibrated, single-channel pipet in volume delivery experiments.

100 play a vital role in the future of the drug delivery field.

101 e combination of hyperthermia-triggered drug delivery followed by ablation showed the best therapeuti

102 h a temporal gap of 2 s added between reward deliveries, found that the rhythmic signals persisted du

103 or neuronal labelling by electrophoretic dye delivery from a suction electrode directly through the n

104 d by the secretion process and natural cargo delivery functions of natural exosomes, biomimetic synth

105 e application of nanoparticles (NPs) to drug delivery has led to the development of novel nanotherape

106 celles as effective carriers for ocular drug delivery highlighting their performance in preclinical s

107 ave found these vesicles are capable of gene delivery, however the consequences of vesicle-mediated t

108 unded publicly and free at the point of care delivery in 50 (42%), 48 (51%), and 46 (49%) countries,

109 In case of a previous LSCS delivery in a female with a viable gestational sac in th

110 AIDS sentinel hospital-based and ART service delivery in China.

111 CSF-1R) blockade and nanoparticle-based drug delivery in murine pulmonary carcinoma.

112 being advocated for increasing drug or gene delivery in neurological diseases.

113 vascular compression and decreased molecular delivery in PDAC.

114 may be a promising application in oral drug delivery in various indications.

115 been described in placenta and cord blood at delivery, in fetal lung, and in buccal epithelium and bl

116 respiratory microbiota members were mode of delivery, infant feeding, crowding, and recent antibioti

117 no difference in the median randomisation to delivery interval between women assigned to sildenafil (

118 To determine whether incomplete radiotherapy delivery is associated with worse clinical outcomes and

119 Customised service delivery is needed to ensure parity for different geogra

120 NP delivery is often via the parenteral route, reliant on a

121 igorous examination of effectiveness of care delivery is similarly warranted.

122 A major challenge with nanoparticles delivery is the quick formation of a protein corona (i.e

123 cotine inhalation is associated with preterm delivery, low birth weight, fetal growth retardation and

124 Escherichia coli) using an efficient genomic delivery machine that is driven by elastic energy stored

125 pregnancy body mass index, smoking, year of delivery, maternal pregestational diabetes, hypertension

126 sing the intracanal pressure during irrigant delivery may result in irrigant extrusion into the bone

127 ve the hymen vs at or beyond the hymen), and delivery method (any vaginal vs all caesarean sections).

128 A simplified formulation, packaging, and delivery method to treat PSBI in low-resource settings c

129 ostics using in vivo liquid biopsy, and drug delivery methods.

130 Thus, in addition to percutaneous drug delivery, microneedles have been considered as an effici

131 We propose that miR-26a delivery might not be a viable therapeutic strategy due

132 other constraints such as vaccine supply and delivery need to be accounted for before such insights c

133 oyed this ProTide strategy for intracellular delivery of a nucleotide antagonist of eIF4E in mantle c

134 Here we show that locoregional and systemic delivery of a rAAV2/8 vector expressing a canine micrody

135 is study, we sought to characterize systemic delivery of a rAAV2/9 vector as a non-invasive means of

136 atients underwent transcatheter, transapical delivery of a self-expanding mitral valve prosthesis and

137 ntage of skin vaccination over intramuscular delivery of a two-fold higher vaccine dose.

138 Currently, sustained in vivo delivery of active bone morphogenetic protein-2 (BMP-2)

139 lowing iatrogenic retinal detachment for the delivery of adeno-associated viral vector encoding Rab E

140 own of LH GLP-1R induced by intraparenchymal delivery of an adeno-associated virus-short hairpin RNA

141 Delivery of an alpha5beta1 inhibitor into murine airways

142 Systemic delivery of anti-miR-181b in angiotensin II-infused Apoe

143 Impaired delivery of antifungals to hyphae within necrotic lesion

144 philic antifungal posaconazole could improve delivery of antifungals to the sites of established infe

145 proximity (i.e. physically linked) to ensure delivery of antigens and adjuvants to the same APCs.

146 hotothermal therapy, radiotherapy, protected delivery of bioactive moieties, anticancer drug delivery

147 Efficient intracellular delivery of biologically active macromolecules has been

148 f live genetically modified bacteria for the delivery of biologics.

149 l route is not yet a viable strategy for the delivery of biomacromolecular therapeutics.

150 Efficient delivery of biomacromolecules (e.g., proteins, nucleic a

151 Delivery of biomolecules to the correct subcellular loca

152 Co-delivery of both chemotherapy drugs and siRNA from a sin

153 ehensive stroke center (CSC) may improve the delivery of care for patients with suspected emergent la

154 ncreatogenesis in pig embryos via zygotic co-delivery of Cas9 mRNA and dual sgRNAs targeting the PDX1

155 After viral delivery of Cre recombinase to hepatocytes in vivo, GsD

156 The safe, non-viral delivery of CRISPR/Cas components would greatly improve

157 tinational study shows major concerns in the delivery of critical care across Latin America, particul

158 RATIONALE: Delivery of Cx43 (connexin 43) to the intercalated disc

159 and simply prepared all-in-one platform for delivery of drugs with different solubilities.

160 For management or policy to ensure the delivery of ecosystem services, integrated approaches th

161 rters in the striatum.SIGNIFICANCE STATEMENT Delivery of ectopic glial cell line-derived neurotrophic

162 or sucrose were employed following intra-PVT delivery of either GLP-1R agonist, exendin-4 (Ex4), or G

163 Intraportal delivery of endothelial cell therapy or saline was techn

164 To enhance the delivery of GAG, we created an in situ gelling rectal de

165 We propose that targeted delivery of GD1a to MS lesions may act as a potential no

166 ells for transplantation and vectors for the delivery of gene therapy.

167 linical therapies for Parkinson's disease by delivery of genes rather than cells.

168 rates the use of non-viral vector based oral delivery of GLP-1 gene through enterohepatic recycling p

169 The delivery of health-care services generates considerable

170 e provides a model to study variation in the delivery of healthcare services.

171 equently, MC degranulation increases surface delivery of HLA class II/peptide, further enhancing stim

172 RATIONALE: Myocardial delivery of human mesenchymal stem cells (hMSCs) is an e

173 Transdermal delivery of hydrophilic drugs is challenging.

174 wo distinct tumor xenograft models, combined delivery of ICOVIR-15K-cBiTE with peripheral blood monon

175 nity is given, including the perspectives of delivery of immunomodulatory therapeutics, engineering i

176 ng by resident macrophages and the localized delivery of innate signals to antigen-experienced B cell

177 Glucose-responsive delivery of insulin mimicking the function of pancreatic

178 ocytosis in live cells and revealed targeted delivery of integrin vesicles to focal adhesions.

179 me-with-lysosome fusion (PLF) results in the delivery of lysosomal hydrolases into phagosomes and in

180 S) for the real-time monitoring of cytosolic delivery of macromolecules.

181 Safe and efficient delivery of messenger RNAs for protein replacement thera

182 Ectopic delivery of miR-194 stimulated migration, invasion, and

183 Intramuscular delivery of miR93 in miR106b-93-25(-/-) PAD mice increas

184 ificant advancement toward broader practical delivery of monoclonal antibody immunotherapeutics for a

185 ivates neutrophil infiltration that mediates delivery of nanotherapeutics into the tumor.

186 Delivery of neurotransmitters across the T-B-cell synaps

187 formin homology 1 domain, which facilitates delivery of new actin subunits to the elongating actin f

188 In the recent past, the intradermal delivery of NPs, via novel dissolving microneedle (MN) a

189 cy, and provide a platform for the cytosolic delivery of nucleic acids.

190 nd-targeted microbubble destruction-mediated delivery of phosphorothioated TRAF3IP2 antisense oligonu

191 concept, trans-/intramucosal and lymph-node delivery of PLGA-PEG nanoparticles was demonstrated in a

192 port, the technique facilitates the targeted delivery of reactive species to a downstream point witho

193 c VTA-PFC fiber photometry signals after the delivery of rewards.

194 Nuclear delivery of several such parasitic RNAs, including Cdg7_

195 photoresponsive polymers, we show cytosolic delivery of small molecules with the spatial resolution

196 d by numerous pathways, ensuring appropriate delivery of specific organelle cargoes to selected subce

197 ongating pollen tube (PT) for the successful delivery of sperm cells to the embryo sac.

198 nsive utility of these tools, locus-specific delivery of synthetic molecules remains limited by a lac

199 By contrast, the site of delivery of the anti-IL-17A and anti-IL-13 Fab' fragment

200 ng HFD-induced cell proliferation by central delivery of the antimitotic drug arabinofuranosyl cytidi

201 ssion in colorectal cancer cells or systemic delivery of the conditioned medium from LOX-overexpressi

202 greatest challenge is the safe and efficient delivery of the CRISPR-Cas9 genome-editing system to tar

203 rogenitor cells, followed by intramyocardial delivery of the progenitor cells into neonatal rat heart

204 score the importance of achieving widespread delivery of therapeutic nucleic acids within brain tumor

205 asialoglycoprotein (ASGPR)-mediated targeted delivery of therapeutically active siRNAs to hepatocytes

206 are a class of nanocarriers for the targeted delivery of therapeutics into aberrant cells that overex

207 l stereotactic radiosurgery (SSRS), allowing delivery of tumoricidal radiation doses with sparing of

208 Mucosal or epicutaneous delivery of vaccines helps target the inductive sites fo

209 h the application of nanoparticle-based drug delivery, opening several exciting avenues for selective

210 ion between maternal PHIV status and preterm delivery or infant BW outcomes is reassuring.

211 the drug penetration for achieving improved delivery outcomes.

212 The growth of publications on drug delivery paralleled the total scientific publications fo

213 er transfusion could augment cerebral oxygen delivery, particularly in vulnerable brain regions, acro

214 type VI secretion system (T6SS), an effector delivery pathway that mediates interbacterial competitio

215 hin brain tumors and provide a promising new delivery platform for localized gene therapy in the brai

216 ) with GAG GM-0111, we created an injectable delivery platform that transitioned in <5min from a liqu

217 e proof-of-principle, we used the TRBO-sgRNA delivery platform to target GFP in Nicotiana benthamiana

218 target multiple risks, and build on existing delivery platforms for feasibility of scale-up.

219 ve emerged as one of the most promising drug delivery platforms for the management of ocular diseases

220 n of oncolytic virus vectors, development of delivery platforms of genes for vaccines or therapy, as

221 (PR, 1.59; 95% CI, 1.38-1.83), and cesarean delivery (PR, 1.08; 95% CI, 1.01-1.14) relative to the c

222 re, parity (three or less vs more than three deliveries), prolapse stage (above the hymen vs at or be

223 ing more controlled and sustained paclitaxel delivery promise to improve the clinical outcomes of fir

224 Optimizing nsPEF delivery protocols to induce sensitization can reduce th

225 lymeric mimics improves non-covalent protein delivery, providing crucial design parameters for the cr

226 Significant differences were seen in delivery-related variables and associated maternal condi

227 action commensurate with inhaled or topical delivery resulted in potent pan-JAK inhibitor 2 (PF-0626

228 tif, and its antibody-mediated intracellular delivery results in 10-fold improvement of its cancer ce

229 38, whole-pregnancy hot exposures increased delivery risk by 6-21% at weeks 34 and 36-38.

230 ated with 12-16% higher and 4-5% lower early delivery risk during warm and cold season, respectively.

231 mbient temperature extremes may affect early delivery risk.

232 ore amenable to a pharmaceutical than a food delivery route, these organisms are often operationally

233 associated with increased rates of operative delivery, stillbirth and post-term labour induction.

234 lls and proteins and the newer generation of delivery strategies that exploits these endogenous appro

235 cessitate molecule modifications and complex delivery strategies.

236 We developed a cell delivery strategy based on a supramolecular liquid cryst

237 A robust and sustainable delivery strategy demands not only good protection of th

238 sue that is 14-F compatible with a motorized delivery system allowing for repositionability.

239 The present study reports a drug delivery system comprising nanostructured lipid carrier

240 The delivery system developed could be employed to create no

241 A chitosan-based microsphere delivery system has been fabricated for controlled relea

242 Therefore, the development of a targeted GEM delivery system is highly desired.

243 The two-agent delivery system presented here possesses notable biophys

244 to their applications in tumor-targeted drug delivery system research.

245 of GAG, we created an in situ gelling rectal delivery system using silk-elastinlike protein polymers

246 to develop an RGC-targeted intraocular drug delivery system using unimolecular micelle nanoparticles

247 Controlled drug release from the delivery system was mediated by physicochemical changes

248 her in mice receiving the targeted nano-drug delivery system when compared to non-targeted system or

249 with use of MAC in an integrated health care delivery system with a capitated payment model.

250 New drug delivery systems are highly needed in research and clini

251 ve compounds using plant-derived proteins as delivery systems has received increasing interest.

252 dge of the role of insurance and health-care delivery systems in protecting the health of diabetic pa

253 pported with a noninvasive positive pressure delivery systems may be feasible alternative to standard

254 ndings suggest S/O/W emulsions are potential delivery systems to incorporate lactase in milk products

255 ccharide nanogels are newly explored as oral delivery systems with promising encapsulation potentials

256 ivery of bioactive moieties, anticancer drug delivery systems, and theranostics (i.e., real-time moni

257 d toward the development of implantable drug-delivery systems.

258 and recent progress of combined NO and drug delivery systems.

259 ign of the next-generation of nanoscale drug delivery systems.

260 es for TB are developed, venue-based vaccine delivery that targets high-risk demographic groups may i

261 on their residence time, with the deeper the delivery, the more prolonged the residence time.

262 After delivery, the offspring were followed for 7 months.

263 Three weeks after corticosterone delivery, there was reduced sensitivity to insulin actio

264 nd 30.0% fewer drones to achieve similar AED delivery times.

265 ktails as a strategy to enhance nanoparticle delivery to a diverse array of molecularly distinct targ

266 h enables controlled and local intracellular delivery to acoustic-transfection technique.

267 Thus, AVD ensures increased oxygen delivery to active muscle fibres by reducing upstream re

268 arian tumor-bearing mice improved paclitaxel delivery to cancer cells by decreasing intratumoral micr

269 To test the hypothesis that SOD delivery to caveolae may specifically inhibit this patho

270 learned regarding variations in nanomedicine delivery to different tumor types and between different

271 a promising nanoplatform for targeted siRNA delivery to EFGR-overexpressing cancer cells.

272 or the fragmentation of ER tubules and their delivery to lysosomes.

273 -associated virus (AAV)-mediated CRISPR/Cas9 delivery to postmitotic photoreceptors is used to target

274 we identified chemical properties promoting delivery to some tissues relative to others.

275 assembling nanocomplex formulation for siRNA delivery to the airways that consists of a liposome (DOT

276 , an alternative route for non-invasive drug delivery to the brain, bypasses the blood-brain-barrier

277 targets to modulate neuroprotection and drug delivery to the CNS.

278 AnkG did not alter ENaC delivery to the membrane from biosynthetic pathways or r

279 on, higher local concentrations and targeted delivery to the site of action appear possible, and most

280 ecrosis in the tumor core and efficient drug delivery to the tumor rim.

281 utic micromotors application for active drug delivery to treat gastric bacterial infection in a mouse

282 ethods that are efficient in their cytotoxin delivery to tumor with reduced dose-limiting toxicities

283 These data are reassuring that oral PrEP delivery to women can continue without the need for conc

284 dendritic cells to facilitate their initial delivery toward follicular dendritic cells to establish

285 nancy if Tdap was received >/=14 days before delivery; trimester was calculated using Tdap date, infa

286 These data suggest a novel platform for nATC delivery using a slight modification of existing cancer

287 Cohort-specific rates of cesarean delivery varied from 9.4% to 37.5%.

288 alidate the self-immolative nanoparticles as delivery vectors of therapeutic miRNA capable of simulta

289 ggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic sch

290 h chemotherapy drugs and siRNA from a single delivery vehicle can have a significant impact on cancer

291 or 5-fluorouracil (5-FU), were assessed as a delivery vehicle for the targeted treatment of pancreati

292 lagen oligomers as an injectable therapeutic delivery vehicle in mice.

293 he synthesis of antibody-functionalized drug delivery vehicles, which were benchmarked against approp

294 ell membranes and optimize the efficiency of delivery vesicles, controlling liposome shape (both stat

295 degrees F increase during the week preceding delivery was associated with 12-16% higher and 4-5% lowe

296 ermeants in tissue after ultrasound-mediated delivery was found to depend on size, with large micropa

297 Delivery was relatively independent of size and charge b

298 een discharged from the maternity ward after delivery were invited to participate in the survey.

299 Among obese women undergoing cesarean delivery who received the standard preoperative cephalos

300 ore frequent in women with previous cesarean deliveries, with adjusted odds ratios of 1.16 (95% CI, 0