ライフサイエンスコーパス: delta cell

1 vely expressed in the somatostatin-secreting delta cell.

2 other and with an additional cell type: the delta cell.

3 endogenous IL-2 RNA degradation in TCR gamma delta cells.

4 in sister kinetochore coorientation in spo13 Delta cells.

5 e cells was missing in all of the above crd1 Delta cells.

6 bud6 delta cells but are proficient in kar9 delta cells.

7 lectively impaired at the bud cortex in bud6 delta cells.

8 in MMS-treated mag1 Delta rad14 Delta rad26 Delta cells.

9 otein exacerbates the defects of sid2-1 sic1 Delta cells.

10 ed for the preanaphase arrest of sid2-1 sic1 Delta cells.

11 ed tubules, similar to the phenotype of dnm1 Delta cells.

12 ions were absent in both nvj1-Delta and vac8-Delta cells.

13 unctioning islets containing alpha, beta and delta cells.

14 ducing beta cells and somatostatin-producing delta cells.

15 er than wild-type in nup188-Delta and nup170-Delta cells.

16 nificantly faster in nup188-Delta and nup170-Delta cells.

17 S-GFP nuclear localization defects of nup188-Delta cells.

18 in the pancreatic islet, especially in islet delta cells.

19 ssed in alpha, beta and PP cells, but not in delta cells.

20 role that is increasingly emerging for gamma delta cells.

21 alpha beta cells, but lack mature TCR gamma delta cells.

22 yruvate kinase activity was elevated in mck1 delta cells.

23 and partially restore actin cables in mdm20 delta cells.

24 ly longer than for rats bearing C6 or C6trkA delta cells.

25 eptors were found predominantly in alpha and delta cells.

26 ne recombination in thymically derived gamma delta cells.

27 atostatin secretion via cognate receptors on delta cells.

28 ion is a frequent occurrence in thymic gamma delta cells.

29 ed translational efficiency of mRNAs in tit1-Delta cells.

30 ce exposure of the Als3 adhesin on slr1Delta/Delta cells.

31 gene up-regulation, and slow growth of sla1-Delta cells.

32 alpha cells but substantial in OFF alpha and delta cells.

33 2 expression and budding are delayed in ccr4 delta cells.

34 pable of increased Ty1 transposition in pmr1 Delta cells.

35 p210 level in Bcr-Abl-transduced SHP-2Delta/Delta cells.

36 ignaling was greatly decreased in SHP-2Delta/Delta cells.

37 ity via gap junction-dependent activation of delta-cells.

38 ed of a collection of >500 alpha-, beta- and delta-cells.

39 alpha-cells, and that Kv2.2 is expressed in delta-cells.

40 d almost exclusively in pancreatic beta- and delta-cells.

41 asse reprogramming of somatostatin-producing delta-cells.

42 glucagon(+) alpha-cells, and somatostatin(+) delta-cells.

43 ct inhibition via somatostatin released from delta-cells.

44 ucing alpha-cells and somatostatin producing delta-cells.

45 high glucose levels due to the inhibition by delta-cells.

46 eatic polypeptide cells but not to alpha- or delta-cells.

47 ed oxidant-induced cell death in Fra-1(Delta/Delta) cells.

48 ss response, are dysregulated in Lmnb1(Delta/Delta) cells.

49 that this association is lost in Lmnb1(Delta/Delta) cells.

50 ects that parallel those found in PLK1(Delta/Delta) cells.

51 mune disease, may be a general one for gamma delta + cells.

52 tions of alpha-cells (5%), beta-cells (92%), delta-cells (1%), and pancreatic polypeptide cells (2%).

53 : 62.9 +/- 3.1% vs. 75.5 +/- 0.9%, P = 0.02; delta-cells: 2.8 +/- 0.5% vs. 4.4 +/- 0.4%, P = 0.05), w

54 f the Fc epsilon RI gamma-chain in TCR-gamma delta cells, a TCR-gamma delta transgenic mouse (G8) has

55 Peripheral TCR gamma delta cells accumulate GFP RNA faster than endogenous IL

56 nhx1 delta cells accumulate late Golgi, prevacuole, and lysos

57 horylation is substantially reduced in SpMYH Delta cells after hydrogen peroxide treatment.

58 The vph1Delta/Delta cells also had abnormal endocytosis and vacuolar m

59 Mice infected with slr1Delta/Delta cells also had an increased brain fungal burden, w

60 CHI-D delta-cells also comprised 10% of cells displaying nucle

61 In OFF Delta cells, AMPAR- and NMDAR-mediated responses could b

62 of age show marked hyperplasia of alpha and delta cells and a relative diminution of beta cells.

63 GAL10 genes is reduced in MMS-treated rad26 Delta cells and also in mag1 Delta rad14 Delta cells, wh

64 ng extracts derived from fir1 Delta and pbp1 Delta cells and from cells lacking the Fir1p interactor,

65 ls were much less invasive than C6 or C6trkA delta cells and had a greater rate of apoptosis.

66 and Spt23p processing is suppressed in rsp5 Delta cells and in wild-type RSP5 cells upon expression

67 PMN occurs normally in apg7-delta cells and is, therefore, not dependent on macroaut

68 Ssb1p stimulates nuclear transport in nup188-Delta cells and NES-containing Ssa1p does not.

69 producing beta cells, somatostatin-producing delta cells and pancreatic polypeptide-producing PP cell

70 al regulator specifically required for islet delta cells and suggest compromised paracrine control as

71 Gamma delta cells and their putative ligands have been linked

72 TCR-alpha/beta+ cells but contain TCR-gamma/delta+ cells and a small population of a unique CD4+, TC

73 Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells.

74 New molecular abnormalities in delta-cells and marked proliferative increases in other

75 tein carboxypeptidase Y is missorted in nhx1 delta cells, and is secreted from the cell.

76 t consisting of two-state alpha-, beta-, and delta-cells, and analyze effects of known chemical inter

77 ls during epithelial infections, since gamma delta + cells are commonly abundant within epithelia.

78 akr1 delta cells are also defective for endocytosis of the al

79 bck2 delta double deletions, cln3 delta ccr4 delta cells are also inviable.

80 Gamma delta cells are attractive candidates for mediators of a

81 ducing beta cells and somatostatin-producing delta cells are drastically reduced, while the numbers o

82 beta cells and the development of TCR gamma delta cells are partially independent of the T domain.

83 pombe growth is resistant to rapamycin, sla1-Delta cells are sensitive, consistent with deficiency of

84 n-essential for yeast cell growth, but sec28 Delta cells are thermosensitive.

85 8alpha/beta T cells disappear, but TCR-gamma/delta cells are unaffected by the absence of beta2m.

86 rga4 Delta cells are wider in diameter and shorter in length,

87 TCR gamma delta cells, as well as alpha beta TCR-NKT cells, exhibi

88 Mutant coatomer from sec28 Delta cells behaves as an unusually large protein comple

89 These contacts are eliminated in bud6 delta cells but are proficient in kar9 delta cells.

90 ressor of the respiratory deficiency of coa2 Delta cells but lacks suppressor activity for two other

91 ps36 enhances the pheromone response in sst2 Delta cells but not in wild type.

92 ted in stimulation of electrical activity in delta-cells but suppression of alpha-cell activity.

93 h pretreatment with hydroxyurea renders tel1-Delta cells (but not wild type) MMS-sensitive, demonstra

94 ta gene rearrangements occur in thymic gamma delta cells, but the frequency of in-frame rearrangement

95 in Schizosaccharomyces pombe tit1+ and tit1-Delta cells by using a beta-galactosidase codon-swap rep

96 ic progenitor cells; and (2) donor TCR gamma/delta+ cells can facilitate the alloengraftment of rigor

97 These results show that (1) host TCR gamma/delta+ cells can reject repopulating donor cells, presum

98 elial lymphocytes (IEL), including TCR gamma delta cells, can develop extrathymically.

99 In contrast, akr1 delta cells cannot carry out ligand-mediated endocytosis

100 Provocatively, both the gamma delta cell clones and primary gamma delta cells in vivo

101 In this report, gamma delta cell clones are described that conform strikingly

102 is increased by greater than 5-fold in akr1 delta cells compared with AKR1 cells.

103 e pancreas shows a dramatic loss of beta and delta cells, contrasting a smaller relative loss of alph

104 juveniles display 'somatostatin-to-insulin' delta-cell conversion, involving dedifferentiation, prol

105 Although cac1 delta cells could establish and maintain transcriptional

106 her, our study demonstrated adult alpha- and delta-cells could regenerate, and both self-duplication

107 iferating cell marker Ki67 showed alpha- and delta-cells could replicate, suggesting self-duplication

108 beta-cells (current density 9 pA/pF), 91% of delta-cells (current density 148 pA/pF), and 6% of alpha

109 rough recognition of autoantigens, and gamma delta-cell-deficient mice, unlike mice deficient in alph

110 e synthesize IL-7, suggesting that TCR gamma delta cell development could occur in either site.

111 progenitors and may regulate alpha, beta and delta cell development.

112 ssion in IL-7Ralpha(-/-) mice to drive gamma/delta cell development.

113 coregulator during islet alpha-, beta-, and delta-cell development through Isl1-dependent and potent

114 tely one-third of HO HML alpha MAT alpha hmr delta cells die because they fail to repair the HO endon

115 at Mnx1 promotes beta-cell while suppressing delta-cell differentiation programs, and is crucial for

116 pancreas, we show that Hhex is required for delta-cell differentiation.

117 rotective immunity, while mice lacking gamma delta + cells display exaggerated intestinal damage, app

118 Mid2p colocalizes with septins, and mid2 Delta cells display disorganized, diffuse septin rings a

119 Here, we report that Lmnb1(Delta/Delta) cells displayed striking nuclear rotation, with a

120 trast, we show that thymically derived gamma delta cells do not make detectable rearrangements of the

121 Of particular interest is the role of gamma delta + cells during epithelial infections, since gamma

122 In she1 Delta cells, dynein is activated throughout the cell cyc

123 fects at 11 degrees C and 37 degrees C. rom2 delta cells exhibit morphological defects.

124 ar compartment requires Nhx1p, and that nhx1 delta cells exhibit phenotypes characteristic of the "cl

125 Unlike TCR-alpha beta cells, TCR-gamma delta cells express a distinct member of the zeta family

126 In snf3 delta cells expression of HXT6 is constitutive even when

127 At high osmolarity, spm1 delta cells fail to form colonies.

128 usly developed tumors, and primary Usp3Delta/Delta cells failed to preserve chromosomal integrity.

129 Second, the inhibitory interactions of delta-cells for glucagon and insulin secretion prevent t

130 xpression, because intraepithelial TCR-gamma delta cells from the zeta-deficient mice did not respond

131 methods to highly purify alpha-, beta-, and delta-cells from human fetal and adult pancreata by intr

132 to the fetal pancreas, and implied immature delta-cell function.

133 ertonic stress or elevated temperature, spm1 delta cells grow as short branched filaments in which th

134 mponents of the ETS was also reduced in crd1 Delta cells grown at elevated temperatures because of re

135 Microarray analyses revealed that mds3 Delta/Delta cells had an expression profile indicative of a hy

136 FLAG-mu cells, MbetaCD treatment of HEK FLAG-delta cells had no effect on acute inhibition or sensiti

137 Fra-1(Delta/Delta) cells had elevated basal levels of antioxidant en

138 ze of ccr4 delta cells, suggesting that ccr4 delta cells have a G(1)-phase cyclin deficiency.

139 eased numbers of T cell receptor (TCR)-gamma/delta cells have been observed in animal models of influ

140 Rapidly aging sip2 Delta cells have higher levels of histone H3 kinase acti

141 for3 Delta cells have normal microtubule dynamics and cortica

142 ast in part because thymically derived gamma delta cells have rarely been studied.

143 These results demonstrate that TCR gamma/delta cells have the capacity to cause acute lethal GVHD

144 Like Oct1(-/-) cells, Lmnb1(Delta/Delta) cells have elevated levels of reactive oxygen spe

145 In TCR gamma delta cells, IL-2-producing cells are a subset of the GF

146 o commit to division, the large size of ccr4 delta cells implies that they may have a size-specific p

147 To define the role of TCR-gamma/delta cells in anti-HSV-1 immunity, TCR-alpha-/- mice tr

148 that contained B cells and monoclonal gamma delta cells in close juxtaposition.

149 lucidate the potential function of TCR gamma/delta cells in GVHD, we have used transgenic (Tg) H-2d m

150 cells suggests a specialized role for gamma/delta cells in mucosal immunity.

151 However, a direct role for TCR-gamma/delta cells in protective immunity for pathogenic viral

152 c potential of Bcr-Abl-transduced SHP-2Delta/Delta cells in recipient animals was compromised.

153 Most of the TCR-gamma/delta cells in the iIELs also bear CD8alpha/alpha, and t

154 ng beta cells and the somatostatin-producing delta cells in the islets of Langerhans in the pancreas.

155 sponsible for the selective deficit in gamma/delta cells in these mice, since a high copy TCR-gamma t

156 he gamma delta cell clones and primary gamma delta cells in vivo showed a strong association of the T

157 that non-beta-cells such as alpha-cells and delta-cells in adults can regenerate, and that the regen

158 ular, it has not been resolved whether gamma delta cells, independent of any other T cells, can help

159 ntation (BMT) confirmed that G8 Tg TCR gamma/delta cells infiltrated GVHD target tissues (skin, liver

160 The infusion of G8 Tg (H-2Td) TCR gamma/delta cells into lethally irradiated [900 cGy total body

161 In contrast, injection of TCR gamma/delta+ cells into irradiated (900 cGy TBI) B6.A-TIaa Boy

162 of intracellular levels of arginine in btn1-Delta cells is detrimental and is suggestive that btn1-D

163 The rapid-aging phenotype of sip2 Delta cells is fully rescued by blocking recombination a

164 trate that the ectopic expression of Pax4 in delta cells is sufficient to induce their conversion int

165 The respiratory deficiency of coa2 Delta cells is suppressed either by the presence of a mu

166 c islets; within the islet the percentage of delta-cells is increased, while the percentage of alpha-

167 , and the resulting cold sensitivity of taz1 Delta cells, is suppressed by mutated alleles of Top2 th

168 Giving 5,000 gamma delta+ cells isolated from the hearts of H3 virus-infect

169 BALB/c mice, transient depletion of all TCR-delta(+) cells just before airway challenge resulted in

170 In both models of HSV-1 infection, TCR-gamma/delta cells limited severe HSV-1-induced epithelial lesi

171 the permissive temperature, cdp1-1 and cdp1 delta cells lost chromosomes at a frequencies approximat

172 IL-2 gene expression in transgenic TCR gamma delta cells may be explained by subset-specific IL-2 gen

173 Thus, this study demonstrates that TCR-gamma/delta cells may play an important regulatory role in hum

174 nt deficiency in tRNA nuclear export in sla1-Delta cells may trigger the AAM response, we show that m

175 ce were found to be susceptible to TCR gamma delta+ cell mediated GVHD-induced lethality characterize

176 t organs are responsible for G8 Tg TCR gamma/delta+ cell mediated lethality.

177 observed protection resulted from TCR-gamma/delta cell-mediated arrest of both viral replication and

178 have specifically examined whether TCR gamma/delta+ cells might be capable of eliminating BM-derived

179 When expressed in a ste5 delta cell, mutant Ste5 proteins that are defective in t

180 e of thymic IL-7 in development of TCR gamma delta cells, newborn TCR beta-deficient (TCR beta(-/-))

181 OFF delta cell NMDA receptors were composed of GluN2B subuni

182 nt with its detection in two-thirds of CHI-D delta-cell nuclei, similar to the fetal pancreas, and im

183 Alternatively, in the absence of Arx, delta cell numbers are increased and Nkx2.2 becomes esse

184 Overall PPAR-delta+ cell numbers declined at 1 day post injury (dpi),

185 In addition, we found delta-cell numbers doubled by Day 6 following STZ treatm

186 In vac8-Delta cells, Nvj1p-GFP generally failed to concentrate i

187 e, no development of graft-derived TCR gamma delta cells occurred, indicating that extrathymic IL-7 d

188 In contrast, intraepithelial TCR-gamma delta cells of G8.zeta-/- mice expressed high levels of

189 At permissive temperatures, rom2 delta cells often form elongated buds and fail to form n

190 s growing on glucose and galactose, and snf1 Delta cells on galactose.

191 y factors secreted by neighbouring beta- and delta-cells (paracrine regulation) have been proposed to

192 nes representing distinct alpha-, beta-, and delta-cell phenotypes.

193 s, and recent experiments confirm that gamma delta cells play a significant role in autoimmune diseas

194 The demonstration that TCR-gamma/delta cells play an important protective role in murine

195 e CD4- CD8+ gamma delta+- or CD4- CD8- gamma delta+-cell population.

196 Instead, rfc2 Delta cells proceed into mitosis with incompletely repli

197 01), alpha-cell (r = -0.32, P < 0.0001), and delta-cell (r = -0.25, P < 0.0001) areas.

198 at islets lacking endogenous Ucn3 have fewer delta cells, reduced somatostatin content, impaired soma

199 eling techniques, we demonstrated alpha- and delta-cell regeneration involved cell proliferation.

200 These data suggest alpha- and delta-cell regeneration occurred rapidly following a sin

201 ons, while the biological functions of gamma delta + cells remain unclear.

202 However, the vph1Delta/Delta cells remained competent for filamentation induced

203 h are expressed in pancreatic islet beta and delta cells, respectively.

204 These Tg TCR gamma/delta+ cells respond vigorously to target cells that exp

205 t, when receptor synthesis is shut off, akr1 delta cells retain the ability to mate longer than do AK

206 VAC1, and subcellular fractionation of vac1 delta cells revealed a striking change in the fractionat

207 In mks1 Delta cells, RTG target gene expression is constitutive,

208 In sec28 Delta cells shifted to 37 degrees C, wild-type alpha-COP

209 Additionally, rga4 Delta cells show an altered growth pattern similar to th

210 of INO80 complexes from arp5 Delta and arp8 Delta cells shows that protein complexes remain intact b

211 In sir2 Delta cells, silencing at the donor mating-type loci, te

212 lls via gap junction-dependent activation of delta-cells/somatostatin secretion.

213 In rad50 delta cells, some DSBs are not repaired until a broken c

214 ncipal role in defining islet beta cell- and delta cell-specific expression of the IAPP gene.

215 co-localized with somatostatin, a pancreatic delta cell-specific hormone.

216 Moreover, this study revealed that delta cells specifically express receptors that receive

217 We suggest that delta-cell SST exerts a tonic inhibitory influence on in

218 sed Sst(-/-) mice to investigate the role of delta-cell SST in the regulation of insulin and glucagon

219 In addition, delta-cell SST is implicated in the nutrient-induced sup

220 However, the specific intraislet function of delta-cell SST remains uncertain.

221 LN2, CLN3, and SWI4 reduces the size of ccr4 delta cells, suggesting that ccr4 delta cells have a G(1

222 , rescues filamentation defects of hir1Delta/Delta cells, suggesting that Hir1 impacts the early phas

223 olar growth similar to that observed in tea1 Delta cells, suggesting that Shk1 and Tea1 may regulate

224 maintain expression of FAS1 in nmt1-451Dino2 Delta cells suggests the existence of another transcript

225 genic mice, only a small proportion of gamma/delta cells survived as long-lived cells; most of these

226 st to TCR transgenic mice, most of the gamma/delta cells surviving in ATx normal mice had a rapid tur

227 -cell analysis revealed that individual cac1 delta cells switch from transcriptionally "off" to trans

228 We find that rtg2 Delta cells take up USA even without the presence of [UR

229 d gene conversions both in Rad+ and in rad50 delta cells that cannot initiate normal meiotic DSBs.

230 rthritis contain a large proportion of gamma delta cells that proliferate in response to the causativ

231 egulated between T2D and ND alpha, beta, and delta cells that were undetectable in paired whole islet

232 TPA treatment of L epsilon delta, cells that overexpressed the PKC-epsilon delta ch

233 glucose level, beta-cells decreasing it, and delta-cells the precise role of which still needs identi

234 for two E2 activities, i.e., ubc4 delta ubc5 delta cells, the receptor was found to be substantially

235 Since PDX-1 is highly enriched in beta and delta cells, these results suggest that this factor play

236 o constitutive endocytosis exhibited by akr1 delta cells, they are competent to carry out ligand-medi

237 A capacity of gamma delta cells to effect or regulate tissue damage is also

238 has been suggested by the inability of plo1 Delta cells to septate and the prolific septation follow

239 uced binding (P=0.0004) of MiaPaCa-MUC4-NIDO(Delta) cells to the fibulin-2 coated plates compared wit

240 The addition of donor G8 TCR gamma/delta+ cells to TCD donor BM was shown to significantly

241 us studies, we found that budding yeast swe1 Delta cells undergo premature entry into mitosis, leadin

242 However, tel1-Delta cells, unlike ATM-deficient cells, do not exhibit

243 OFF alpha and delta cells used NMDA receptors for encoding either the

244 lp1r expression include pancreatic beta- and delta-cells, vascular smooth muscle, cardiac atrium, gas

245 tivation of the beta-cells propagates to the delta-cells via gap junctions, and the consequential sti

246 on the turnover and lifespan of murine gamma/delta cells was obtained by administering the DNA precur

247 d no effect on AHR, and depletion of all TCR-delta(+) cells was no more effective than depletion of V

248 Activation of the delta-cells was rapid and sensitive to the gap junction

249 e proportion of islets composed of beta- and delta-cells was reduced in the transgenic mice compared

250 e whether such plasticity was also shared by delta cells, we generated and characterized transgenic a

251 In human islets, most beta, alpha, and delta cells were aligned along blood vessels with no par

252 In addition, cac1 delta cells were defective for transcriptional silencing

253 ive alpha cells, and somatostatin-containing delta cells were found scattered throughout the human is

254 Donor- and host-derived TCR gamma delta cells were recovered from thymus grafts, spleen, a

255 te-passage Mre11(ATLD1/ATLD1) Tert(Delta)(/)(Delta) cells were as short as those from Tert(Delta)(/)(

256 Both TCR-alpha-/beta+ and TCR-delta+ cells were found to be capable of producing IL-4;

257 d26 Delta cells and also in mag1 Delta rad14 Delta cells, whereas a very severe reduction in transcri

258 CR alpha beta receptor and not the TCR gamma delta cells, which exclusively express CD8 alpha alpha.

259 f endocrine cells, primarily alpha, beta and delta cells, which secrete glucagon, insulin, and somato

260 required for development of thymic TCR gamma delta cells, while peripheral IL-7 was sufficient for de

261 hosphotyrosine accumulates on Cdc28 in cdc55 delta cells whose spindles have been depolymerized, and

262 arrest is maintained in the majority of bub3 Delta cells, yet they die, suggesting that Bub3p is esse