1 fic entry of hepatitis B virus and hepatitis
delta virus.
2 ding a self-cleaving ribozyme from hepatitis
delta virus.
3 n host cell entry factor for hepatitis B and
delta viruses.
4 rus, human immunodeficiency virus, hepatitis
delta virus,
and alanine aminotransferase levels were li
5 Self-cleaving hammerhead, hairpin, hepatitis
delta virus,
and glmS ribozymes comprise a family of sma
6 ing RNAs: the hammerhead, hairpin, hepatitis
delta virus,
and in vitro-selected lead-dependent ribozy
7 mosaic virus 35S promoter and the hepatitis
delta virus antigenomic ribozyme with a downstream nopal
8 In the hepatitis
delta virus antigenomic ribozyme, imidazole buffer rescu
9 In the ribozyme of hepatitis
delta virus antigenomic RNA, two short duplexes, P2 and
10 Hepatitis D virus (also known as hepatitis
delta virus)
can establish a persistent infection in peo
11 The RNA enzyme (ribozyme) from hepatitis
delta virus catalyzes self-cleavage of a phosphodiester
12 el enabling functional genomics of hepatitis
delta virus entry and infection.
13 Hepatitis
delta virus expresses two essential proteins, the small
14 ary structure, based on a modified hepatitis
delta virus genome.
15 iety of catalysts that include the hepatitis
delta virus,
hammerhead, X motif and Tetrahymena group I
16 Ribozymes of hepatitis
delta virus have been proposed to use an active-site cyt
17 /W site) in the antigenomic RNA of hepatitis
delta virus (
HDV) allows two essential forms of the vira
18 Hepatitis
delta virus (
HDV) and cytoplasmic polyadenylation elemen
19 formation on the early kinetics of hepatitis
delta virus (
HDV) and hepatitis B surface antigen (HBsAg
20 small, 195-amino-acid form of the hepatitis
delta virus (
HDV) antigen (deltaAg-S) is essential for g
21 RNA editing of the hepatitis
delta virus (
HDV) antigenome at the amber/W site by the
22 Hepatitis
delta virus (
HDV) assembly also uses the envelope protei
23 is delta antigen (HDAg-L) mediates hepatitis
delta virus (
HDV) assembly and inhibits HDV RNA replicat
24 Hepatitis
delta virus (
HDV) can dramatically worsen liver disease
25 omic and antigenomic RNAs of human hepatitis
delta virus (
HDV) can fold into a rod-like structure wit
26 The circular RNA genome of hepatitis
delta virus (
HDV) can fold into an unbranched rodlike st
27 The antigenomic RNA of hepatitis
delta virus (
HDV) can form a short duplex, P2a, in which
28 Hepatitis
delta virus (
HDV) causes both acute and chronic liver di
29 Hepatitis
delta virus (
HDV) causes the most severe form of human v
30 The two ribozymes of hepatitis
delta virus (
HDV) cleave faster in divalent metal ions t
31 Hepatitis
delta virus (
HDV) contains a circular RNA which encodes
32 Hepatitis
delta virus (
HDV) contains a viroid-like circular RNA th
33 Hepatitis
delta virus (
HDV) contains a viroid-like circular RNA th
34 Hepatitis
delta virus (
HDV) contains two RNA species (HDV-S and HD
35 Hepatitis
delta virus (
HDV) contains two types of hepatitis delta
36 -S and deltaAg-L, respectively) of hepatitis
delta virus (
HDV) differ only in the 19-aa C-terminal ex
37 The human pathogenic hepatitis
delta virus (
HDV) employs a unique self-cleaving catalyt
38 Hepatitis
delta virus (
HDV) encodes one protein, hepatitis delta a
39 Hepatitis
delta virus (
HDV) encodes two isoforms of its principal
40 Hepatitis
delta virus (
HDV) expresses two essential proteins with
41 ize self-cleaving ribozymes of the hepatitis
delta virus (
HDV) family for processing their 5' termini
42 ular genome and antigenome RNAs of hepatitis
delta virus (
HDV) form characteristic unbranched, quasi-
43 as 5 days after DNA copies of the hepatitis
delta virus (
HDV) genome or even in vitro-transcribed HD
44 Hepatitis
delta virus (
HDV) genome replication requires the virus-
45 d with a cDNA expressing a mutated hepatitis
delta virus (
HDV) genome that could only replicate by us
46 ng sequences or ribozymes from the hepatitis
delta virus (
HDV) genomic RNA and its complement form si
47 The genome of the human hepatitis
delta virus (
HDV) harbors a self-cleaving catalytic RNA
48 Hepatitis
delta virus (
HDV) has a circular RNA genome that replica
49 The ribozymes of hepatitis
delta virus (
HDV) have so far been studied primarily in
50 Assembly of hepatitis
delta virus (
HDV) in infected human hepatocytes involves
51 Hepatitis
delta virus (
HDV) infection and spread in vivo are depen
52 Therapies for chronic hepatitis
delta virus (
HDV) infection are unsatisfactory.
53 of chronic liver disease caused by hepatitis
delta virus (
HDV) infection superimposed on chronic hepa
54 f 46 Italian patients with chronic hepatitis
delta virus (
HDV) infection were analyzed for HDV RNA by
55 rus (HBV) genotypes A to I support hepatitis
delta virus (
HDV) infectivity.
56 A woodchuck-derived hepatitis
delta virus (
HDV) inoculum was created by transfection o
57 e replication of the RNA genome of hepatitis
delta virus (
HDV) involves redirection of RNA polymerase
58 The genome of hepatitis
delta virus (
HDV) is a 1,679-nucleotide (nt) single-stra
59 Hepatitis
delta virus (
HDV) is a cause of acute and chronic liver
60 Hepatitis
delta virus (
HDV) is a circular pathogenic RNA that uses
61 Hepatitis
delta virus (
HDV) is a highly pathogenic human RNA virus
62 The hepatitis
delta virus (
HDV) is a human pathogen and satellite RNA
63 Hepatitis
delta virus (
HDV) is a natural subviral agent of human h
64 Human hepatitis
delta virus (
HDV) is a natural subviral agent that uses
65 Hepatitis
delta virus (
HDV) is a pathogenic human virus whose RNA
66 Hepatitis
delta virus (
HDV) is a satellite virus of hepatitis B vi
67 Hepatitis
delta virus (
HDV) is a small single-stranded RNA satelli
68 Hepatitis
delta virus (
HDV) is a small, defective RNA virus that c
69 Hepatitis
delta virus (
HDV) is a subviral human pathogen that requ
70 Hepatitis
delta virus (
HDV) is a subviral human pathogen that uses
71 Hepatitis
delta virus (
HDV) is a subviral pathogen that increases
72 Hepatitis
delta virus (
HDV) is known to express a protein termed t
73 In a natural setting, hepatitis
delta virus (
HDV) is only found in patients that are als
74 Hepatitis
delta virus (
HDV) is responsible for the most severe for
75 Intrinsic to the life cycle of hepatitis
delta virus (
HDV) is the fact that its RNAs undergo diff
76 Hepatitis
delta virus (
HDV) is the most severe form of viral hepat
77 The self-cleaving ribozyme of the hepatitis
delta virus (
HDV) is the only catalytic RNA known to be
78 Hepatitis
delta virus (
HDV) is unique relative to all known animal
79 ations of genetic variations among hepatitis
delta virus (
HDV) isolates have focused principally on p
80 Most hepatitis
delta virus (
HDV) prevalence estimates from the United S
81 Hepatitis
delta virus (
HDV) produces two essential forms of the so
82 The large form of the hepatitis
delta virus (
HDV) protein (L) can be isoprenylated near
83 Hepatitis
delta virus (
HDV) replicates by a double rolling-circle
84 Hepatitis
delta virus (
HDV) replicates by RNA-dependent RNA synthe
85 Hepatitis
delta virus (
HDV) replicates its circular RNA genome via
86 Hepatitis
delta virus (
HDV) replication and packaging require inte
87 Hepatitis
delta virus (
HDV) replication involves processing and ac
88 Moderation of hepatitis
delta virus (
HDV) replication is a likely prerequisite i
89 mic and antigenomic ribozymes from hepatitis
delta virus (
HDV) requires divalent cation for optimal a
90 Hepatitis
delta virus (
HDV) requires host RNA editing at the viral
91 Replication of the genome of hepatitis
delta virus (
HDV) requires RNA-directed RNA synthesis us
92 The hepatitis
delta virus (
HDV) ribozyme and HDV-like ribozymes are se
93 RNA transcripts: one encodes a 3'- hepatitis
delta virus (
HDV) ribozyme and the other, used in combin
94 d magnesium hydrate in crystals of hepatitis
delta virus (
HDV) ribozyme and to follow the effects of
95 While the hepatitis
delta virus (
HDV) ribozyme can undergo self-cleavage in
96 The hepatitis
delta virus (
HDV) ribozyme catalyzes a self-cleavage rea
97 The hepatitis
delta virus (
HDV) ribozyme is a self-cleaving RNA enzyme
98 The hepatitis
delta virus (
HDV) ribozyme is a self-cleaving RNA that r
99 bozyme related in structure to the hepatitis
delta virus (
HDV) ribozyme occurs in a number of mammals
100 p II intron domain 5-domain 6, and hepatitis
delta virus (
HDV) ribozyme RNA constructs.
101 The Hepatitis
Delta Virus (
HDV) ribozyme self-cleaving activity in 20
102 forms of the cis-cleaving genomic hepatitis
delta virus (
HDV) ribozyme show a divalent metal ion bou
103 The hepatitis
delta virus (
HDV) ribozyme uses a cytosine to facilitate
104 The hepatitis
delta virus (
HDV) ribozyme uses the nucleobase C75 and a
105 The Hepatitis
Delta Virus (
HDV) ribozyme was the first RNA enzyme prop
106 Well-ordered crystals of a genomic hepatitis
delta virus (
HDV) ribozyme, a large, globular RNA, were
107 In the hepatitis
delta virus (
HDV) ribozyme, site-specific self-cleavage
108 In the case of the hepatitis
delta virus (
HDV) ribozyme, there are three high-resolut
109 t structure similar to that of the hepatitis
delta virus (
HDV) ribozyme.
110 The hepatitis
delta virus (
HDV) ribozymes are self-cleaving RNA sequen
111 ctures proposed for the cis-acting hepatitis
delta virus (
HDV) ribozymes contain four duplex regions,
112 Hepatitis
delta virus (
HDV) ribozymes employ multiple catalytic st
113 biochemically related to the human hepatitis
delta virus (
HDV) ribozymes.
114 Hepatitis
delta virus (
HDV) RNA forms an unbranched rod structure
115 ation for the ribozyme activity of hepatitis
delta virus (
HDV) RNA in infected cells is unknown.
116 ite in the antigenomic sequence of hepatitis
delta virus (
HDV) RNA is 33-nt downstream of the poly(A)
117 Hepatitis
delta virus (
HDV) RNA replicates in the nuclei of virus-
118 When the hepatitis
delta virus (
HDV) RNA was released by treatment of viral
119 A replication and transcription of hepatitis
delta virus (
HDV) RNA, generating a full-length (1.7-kb)
120 models of the replication of human hepatitis
delta virus (
HDV) RNA, it is generally assumed that circ
121 1,679-nucleotide (nt) unit-length hepatitis
delta virus (
HDV) RNAs in the livers of two HDV-infected
122 Hepatitis B virus (HBV) and hepatitis
delta virus (
HDV) share the HBV envelope proteins.
123 irected mRNA constructs containing hepatitis
delta virus (
HDV) target sequences.
124 -mediated RNA-editing event allows hepatitis
delta virus (
HDV) to express two essential proteins, the
125 Hepatitis
delta virus (
HDV) uses a host-encoded RNA-editing activi
126 Hepatitis
delta virus (
HDV) uses genomic and antigenomic ribozymes
127 d changes in hepatitis B virus and hepatitis
delta virus (
HDV) viral loads (VL) during tenofovir-cont
128 Efficient assembly of hepatitis
delta virus (
HDV) was achieved by cotransfection of Huh7
129 gs are currently available against hepatitis
delta virus (
HDV), a defective virus leading to the most
130 Infection by the hepatitis
delta virus (
HDV), a satellite of the hepatitis B virus
131 ication of the RNA genome of human hepatitis
delta virus (
HDV), a series of linear RNAs containing HD
132 Hepatitis
delta virus (
HDV), a single-stranded RNA virus, bears a
133 rimary human hepatocytes either by hepatitis
delta virus (
HDV), a subviral agent that uses HBV envelo
134 role in the replication scheme of hepatitis
delta virus (
HDV), allowing the virus to produce two fun
135 The hepatitis
delta virus (
HDV), an infectious human pathogen affectin
136 The hepatitis
delta virus (
HDV), an infectious human pathogen and sate
137 As for hepatitis
delta virus (
HDV), another cause of liver disease, no ef
138 of human hepatitis B virus (HBV), hepatitis
delta virus (
HDV), requires only the envelope proteins f
139 tigenomic RNA strands of the human hepatitis
delta virus (
HDV), where they serve a crucial role in pa
140 No specific therapy exists for hepatitis
delta virus (
HDV), which can cause severe liver disease.
141 g an RNA-dependent RNA polymerase, hepatitis
delta virus (
HDV), which contains a circular RNA of 1.7
142 ficulties can be circumvented with hepatitis
delta virus (
HDV), which needs the HBV large envelope pr
143 ilar to those observed for HBV and hepatitis
delta virus (
HDV), which shares the same L, M, and S.
144 We show that large hepatitis
delta virus (
HDV)-like ribozymes are activated by periph
145 Patients transplanted for hepatitis
delta virus (
HDV)-related cirrhosis are reported to have
146 a is the only treatment option for hepatitis
delta virus (
HDV).
147 Activity of the two ribozymes from hepatitis
delta virus in monovalent salts was examined and compare
148 e useful therapeutic agents for treatment of
delta virus infection.
149 The hepatitis
delta virus large antigen (lHDAg) is a virally encoded p
150 The two forms of the hepatitis
delta virus ribozyme are derived from the genomic and an
151 sense) of the NS gene joined to a hepatitis
delta virus ribozyme at its 3' end.
152 erase promoter at the 5' end and a hepatitis
delta virus ribozyme at the 3' end.
153 The hepatitis
delta virus ribozyme catalyzes an RNA cleavage reaction
154 promoter and upstream of the human hepatitis
delta virus ribozyme domain, we inserted a complete cDNA
155 In contrast, a linear form of the
delta virus ribozyme expressed as part of an unprocessed
156 ecular dynamics simulations on the hepatitis
delta virus ribozyme in the product form and assessed co
157 The hepatitis
delta virus ribozyme is a small, self-cleaving RNA with
158 ase promoter and the autocatalytic hepatitis
delta virus ribozyme of a transcription plasmid, pBR 322
159 NA plasmid containing a cis-acting hepatitis
delta virus ribozyme to control 3' cleavage.
160 f the plasmid, a cDNA encoding the hepatitis
delta virus ribozyme was added to the 3' end of the FMDV
161 seP and an artificial trans-acting hepatitis
delta virus ribozyme were expressed as the exon portion
162 om the antigenomic sequence of the hepatitis
delta virus ribozyme with the P2 and P3 stems from the r
163 RNAs, the hairpin ribozyme and the hepatitis
delta virus ribozyme, and that the shifts are likely to
164 n yellows virus pseudoknot and the hepatitis
delta virus ribozyme, despite distinct structural contex
165 For the hepatitis
delta virus ribozyme, we predict several nonnative stems
166 T7 RNA polymerase and cleavage by hepatitis
delta virus ribozyme.
167 Hepatitis
delta virus ribozymes have been proposed to perform self
168 normal; after several years, both hepatitis
delta virus RNA and serum HBsAg became undetectable.
169 The two ribozymes found in hepatitis
delta virus RNA form related but non-identical secondary
170 The unusual structure of hepatitis
delta virus RNA has previously been shown to enhance its
171 itis B surface antigen (HBsAg) and hepatitis
delta virus RNA.
172 ein complexes (RNPs) formed by the hepatitis
delta virus RNAs and protein, HDAg, perform critical rol
173 gen, it was partially defective in hepatitis
delta virus RNP incorporation.
174 pe proteins, hepatitis B virus and hepatitis
delta virus use the sodium/taurocholate cotransporting p