ライフサイエンスコーパス: demethylase

1 it the cytochrome P450 enzyme sterol 14alpha-demethylase.

2 t Miz1 target gene Kdm8, encoding a H3K36me2 demethylase.

3 ere, we show that mammalian ALKBH1 is a tRNA demethylase.

4 ne-6) DNA methyltransferase, and the Tet DNA demethylase.

5 rst PAS enzyme: a haem-dependent oxidative N-demethylase.

6 stone demethylases but not DNA methylases or demethylases.

7 controlled by DNA methyltransferases and DNA demethylases.

8 of biological significance of counteracting demethylases.

9 ndent enzyme of the Jumonji family of lysine demethylases.

10 of the KDM4 (JMJD2) family of histone lysine demethylases.

11 er structurally characterized Jumonji domain demethylases.

12 KG analogues that do not sensitize wild type demethylases.

13 c activity of JmjC-domain containing histone demethylases.

14 (ALDH) activity and upregulation of histone demethylases.

15 lysine and arginine methyl transferases and demethylases.

16 utarate caused inhibition of several histone demethylases.

17 Lysine-specific demethylase 1 (KDM1A) is a transcriptional coregulator t

18 rated that crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) fa

19 transcriptional corepressor Lysine-Specific Demethylase 1 (LSD1) and its dominant-negative splicing

20 1822-1836) identify lysine-specific demethylase 1 (LSD1) as a pivotal regulator of whole-bod

21 iption factor (REST)-lysine-specific histone demethylase 1 (LSD1) co-repressor complex associates wit

22 The lysine specific demethylase 1 (LSD1) demethylates at both of these lysin

23 Lysine-specific demethylase 1 (LSD1) has been reported to repress and ac

24 Inhibition of lysine specific demethylase 1 (LSD1) has been shown to induce the differ

25 The epigenetic writer lysine-specific demethylase 1 (LSD1) is aberrantly upregulated in many c

26 Lysine-specific demethylase 1 (Lsd1) is an epigenetic eraser enzyme posi

27 Lysine specific demethylase 1 (LSD1) is responsible for maintaining bala

28 t it remains elusive whether lysine-specific demethylase 1 (LSD1) regulates the stemness properties o

29 Here, we report that lysine-specific demethylase 1 (LSD1) upregulates hypoxia responses by de

30 Lysine-specific demethylase 1 (LSD1), which has been considered as a pot

31 GSK2879552, a lysine demethylase 1 inhibitor currently in clinical trials for

32 Lysine specific demethylase 1 KDM1A (LSD1) regulates histone methylation

33 Here we found that LSD1 (lysine-specific demethylase 1), a histone demethylase, regulates brown a

34 histone tails, LSD1-CoREST (lysine-specific demethylase 1; REST corepressor) is an ideal model syste

35 ides as an H3K4 demethylase, lysine-specific demethylase-1 (LSD1) has been shown to promote H3K9 deme

36 identify the MKL1 interactor Jumonji domain demethylase 1A (JMJD1A) as a novel Hh pathway component

37 dopsis JHDM2 (JmjC domain-containing histone demethylase 2) family protein, which modulates defense a

38 Using histone lysine demethylase 4 (KDM4) as a proof-of-concept, we show that

39 found that overexpression of lysine-specific demethylase 4A (KDM4A, also known as JMJD2A) was positiv

40 Lysine demethylase 4C (KDM4C), an H3K9me3 demethylase, localize

41 Overexpression of lysine-specific demethylase 4d removes H3K9me3 marks from Xenopus embryo

42 genes, KDM5D, which encodes Lys (K)-specific demethylase 5D, showed increased methylation at several

43 coding a putative Jumonji C-type H3K9me2/me3 demethylase, a regulator of chromatin state.

44 worth and colleagues reveal that UTX and its demethylase activity are required in the muscle stem cel

45 tarate binding sites, and displays H3K9me1/2 demethylase activity both in vitro and in vivo.

46 ggest that the JmjC domain of JMJ24 has lost demethylase activity but has been retained as a binding

47 th P bodies, suggesting that atALKBH9B m(6)A demethylase activity could be linked to mRNA silencing a

48 Pharmacologic inhibition of Jmjd3 H3K27 demethylase activity during SAA treatment or blockade of

49 h its H3K27 demethylase activity, as loss of demethylase activity either by chemical inhibition or kn

50 Selective inactivation of demethylase activity eliminates H4K20me1 enrichment in s

51 Furthermore, TET1 catalytic domain possessed demethylase activity in cancer cells, being able to inhi

52 We demonstrate that dKDM4A demethylase activity is dispensable for PEV.

53 n or pharmacological inhibition of the KDM1A demethylase activity itself could serve as a novel thera

54 Notably, the demethylase activity of KDM5A is required for activation

55 Further, we found that GSK-J1 inhibited the demethylase activity of KDM5C with 8.5-fold increased po

56 uscle regenerative process revealed that the demethylase activity of UTX is required for expression o

57 lysis reduces thiol labeling and inactivates demethylase activity over time.

58 JMJD1A (wild type or mutant lacking histone demethylase activity) bound to HUWE1, attenuated HUWE1-d

59 diates muscle regeneration through its H3K27 demethylase activity, as loss of demethylase activity ei

60 xpression of UTY, a paralog that lacks H3K27 demethylase activity, suggesting an enzyme-independent r

61 We demonstrate that UTX, in a demethylase activity-independent manner, facilitates con

62 regulated IRF4 expression by enhancing JMJD3 demethylase activity.

63 main protein with E3 ligase activity, but no demethylase activity.

64 ylated peptides and determination of histone demethylase activity.

65 itor differentiation, but also modulates its demethylase activity.

66 ing the conclusion that it requires H3K27Me3 demethylase activity.

67 s the inhibitory effect of Deltex2 on Jmjd1c demethylase activity.

68 s Jmjd1c monoubiquitination and inhibits its demethylase activity.

69 ession program and epigenetic landscape in a demethylase-activity-dependent manner.

70 We show that the m(6)A demethylase ALKBH5 is highly expressed in glioblastoma s

71 st methyltransferases METTL3 and METTL14 and demethylases ALKBH5 and FTO, and knockdown of methyltran

72 pment of tool molecules that inhibit Jumonji demethylases allows for the investigation of cancer-asso

73 Discoveries of RNA demethylases, along with advances in mass spectrometry a

74 e Jumonji C (JmjC)-domain-containing histone demethylases also require ascorbate as a cofactor for hi

75 identified 45 SET methyltransferase, 22 JmjC demethylase and 4 LSD demethylase genes in F. vesca.

76 enase activities, acting as both an arginine demethylase and a lysyl-hydroxylase.

77 function of immune cells, and revealed both demethylase and demethylase-independent activities of th

78 new genomic targeting mechanism for an H3K27 demethylase and demonstrates its key role in recruiting

79 combination therapy targeting both the KDM5A demethylase and histone deacetylases.

80 jumonji C (Jmj C) domain-containing protein demethylase and hydroxylase, has been implicated in an a

81 ssor complex with a histone H3K9Me2-specific demethylase and promote adipogenesis and smooth muscle d

82 an inverse correlation between NO66 histone demethylase and the activity of IGF1R/Akt signaling.

83 haracterized as a euchromatic histone H3 K36 demethylase and transcriptional regulator, predominantly

84 However, the roles of histone demethylases and activating histone modifications such a

85 A demethylases and Jumonji family of histone demethylases and cause epigenetic changes that lead to a

86 droxyglutarate inhibit the TET family of DNA demethylases and Jumonji family of histone demethylases

87 physically interacts with JMJD3, a H3K27me3 demethylase, and conditional depletion of JMJD3 leads to

88 written by methyltransferases and erased by demethylases, and result in modification of chromatin st

89 In addition to HIFs, multiple histone demethylases are altered in their expression and activit

90 etic processes such as methyltransferases or demethylases are becoming highly utilized for their pers

91 The KDM4 histone demethylases are conserved epigenetic regulators linked

92 Histone H3 lysine-4 (H3K4) demethylases are key chromatin modifiers that establish

93 rotonin signalling, identifying this histone demethylase as a potential target for the treatment of a

94 for their further study and validate 14alpha-demethylase as the target for azoles in Acanthamoeba.

95 monstrate that voriconazole inhibits 14alpha-demethylase as treatment inhibits the production of ergo

96 novel pharmacologic basis to target histone demethylases as an indirect MYC-targeting approach for c

97 nterplays between the methyltransferases and demethylase at the epitranscriptomic layer of gene regul

98 remodelers, such as BRAHMA (BRM), and H3K27 demethylases both have active roles in regulating gene e

99 This work defines LigM as a distinct demethylase, both structurally and functionally, and pro

100 Saccharomyces cerevisiae, which has histone demethylases but not DNA methylases or demethylases.

101 ch requires co-recruitment of KDM4C, an H3K9 demethylase, by chimeric transcription factors to mediat

102 versible, the discovery of the Utx and Jmjd3 demethylases changed this notion, raising new questions

103 TET proteins are active CpG demethylases converting 5-methylcytosine to 5-hydroxymet

104 Jmjd2 H3K9 demethylases cooperate in promoting mouse embryonic stem

105 Sterol 14alpha-demethylase (CYP51) is a cytochrome P450 enzyme required

106 partial redundancy with UTY, a Y-chromosome demethylase-dead homolog.

107 These findings are substantiated through demethylase-dead knockin mutation of UTX, which supports

108 either by chemical inhibition or knock-in of demethylase-dead UTX resulted in defective muscle repair

109 ethyltransferases increases, while silencing demethylases decreases, ZIKV production.

110 In most cases, DMSP lyases and DMSP demethylases (DmdAs) have low substrate affinities, but

111 Jmjd6, a demethylase downregulated with LRP6 deficiency, inhibits

112 specifically histone and DNA methylases and demethylases, drive hematopoietic cancer could provide n

113 and KDM5 (JARID1) families of histone lysine demethylases (e.g., 1), further optimization led to the

114 Temporally, AA-dependent histone demethylase effects are important early, whereas Tet enz

115 36 methyltransferase, SDG8, and the H3K27me3 demethylase, ELF6.

116 ating that developing compounds which target demethylase enzymatic activity may be efficacious in tre

117 We show that the histone demethylase enzyme Kdm5b (Jarid1b) negatively regulates

118 thetic pathway via inhibition of the 14alpha-demethylase enzyme present in fungal cells.

119 To discover new inhibitors for the KDM4 demethylases, enzymes overexpressed in several cancers,

120 owever, inactivation of the putative histone demethylase Epe1 allows H3K9 methylation and silent chro

121 The putative JmjC domain H3K9 demethylase, Epe1, and the chromodomain of the H3K9 meth

122 s regulated by methyltransferases (writers), demethylases (erasers), and m(6)A-binding proteins (read

123 The discovery of FTO as the first m6A mRNA demethylase established the concept of reversible RNA mo

124 g cells with high Notch activity and histone demethylase expression are present in primary glioblasto

125 Histone lysine demethylases facilitate the activity of oncogenic transc

126 emerging targeted inhibitors of this histone demethylase family in cancer therapy.

127 ntial TTD binding properties across the KDM4 demethylase family may differentiate their targets in th

128 This H3K4 demethylase family participates in multiple repressive t

129 1.81-A crystal structure, revealing a unique demethylase fold and a canonical folate-binding domain.

130 Alkbh1 encodes a demethylase for N(6)-methyladenine.

131 se METTL3 (methyltransferase-like 3) and the demethylase FTO (fat mass and obesity-associated protein

132 Knocking down the m(6)A demethylase FTO in the mPFC, which increases total m(6)A

133 ns, in vitro, modulation of m(6)A by the RNA demethylase FTO influenced the degradation profiles of a

134 ining the role of the best characterized RNA demethylase, FTO (fat mass and obesity-associated) in me

135 se a nuclease-deficient Cas9 (dCas9)-histone demethylase fusion to functionally characterize previous

136 of OCT4 to the promoter of Kdm2b, a histone demethylase gene that promotes reprogramming by reactiva

137 Pseudomonas caffeine demethylase genes are expressed in vivo in the gut of H.

138 yltransferase, 22 JmjC demethylase and 4 LSD demethylase genes in F. vesca.

139 volving histone methyltransferase or histone demethylase genes were detected in 111 samples (2.5%) an

140 th hepatocyte knockout of lanosterol 14alpha-demethylase (H(Cyp51-/-)) from cholesterol synthesis is

141 The histone demethylase IBM1 suppresses DNA methylation and gene sil

142 ns of histone methyltransferases and histone demethylases in AML, especially MLL-rearranged leukaemia

143 are the first genetically characterized DNA demethylases in eukaryotes.

144 among the Jumonji domain-containing histone demethylases in that there is an atypical insertion of a

145 Ciclopirox targeted several histone demethylases, including KDM4B implicated in MYC function

146 ing H3K4 methylation is catalyzed by histone demethylases, including the Jumonji C (JmjC) KDM5 subfam

147 une cells, and revealed both demethylase and demethylase-independent activities of these enzymes.

148 component stabilizing the GLI1 protein in a demethylase-independent manner.

149 naltered in mutant tissue, and support for a demethylase-independent mechanism came from mice express

150 Thus, NC cells may require demethylase-independent UTX activity.

151 Here we show that multiple histone demethylases influence the viability and poor prognosis

152 tion testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had s

153 n through in vivo administration of an H3K27 demethylase inhibitor that efficiently kills TAL1-positi

154 ngal agent ciclopirox as a novel pan-histone demethylase inhibitor.

155 Conversely, treatment with histone demethylase inhibitors increases heterochromatin and chr

156 ch should prove useful in the design of KDM5 demethylase inhibitors with improved potency and selecti

157 Lanosterol 14-alpha demethylase is a key enzyme intermediating the biosynthe

158 ing a reporter for expression of the H3K4me3 demethylase JARID1B to isolate a JARID1B(high) fraction

159 Controlled by the histone demethylase JARID1B, MANTIS was downregulated in patient

160 rray analysis after knockdown of the histone demethylase JARID1B.

161 For example, the histone demethylase JARID1C is frequently inactivated in patient

162 as a transcriptional corepressor of the H3K4 demethylase JARID1D.

163 KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC KDMs, KDM2-7), focusing on the academ

164 We identify the conserved histone lysine demethylases jmjd-1.2/PHF8 and jmjd-3.1/JMJD3 as positiv

165 Histone 3 lysine 9 (H3K9) demethylase JMJD1A regulates beta-adrenergic-induced sys

166 ving OCA-B recruitment of the histone lysine demethylase Jmjd1a to targets such as Il2, Ifng, and Zbt

167 The histone demethylase JMJD1A, which controls gene expression by ep

168 Here we demonstrate that the histone demethylase JMJD1C functions as a coactivator for RUNX1-

169 inding DNA, Oct4 recruits the histone lysine demethylase Jmjd1c.

170 ent of histone methylase (COMPASS)-, histone demethylase (Jmjd2a/Jmjd3)-, and SWI/SNF-containing comp

171 s for the double Tudor domain of the histone demethylase JMJD2C.

172 iqutination and stabilization of the histone demethylase Jmjd2d.

173 lysine methyltransferase PRDM9 or the lysine demethylase JMJD2E.

174 found that in diabetic conditions the H3K27 demethylase Jmjd3 drives IL-12 production in macrophages

175 Additionally, inhibition of the H3K27 demethylase JMJD3 in naive CD4 T cells demonstrates how

176 lone transiently increased the H3K27 histone demethylase Jmjd3, persistently increased bone marrow Cs

177 y repressive H3K27me3 and is executed by its demethylase Jmjd3.

178 nhibition of the Jumonji C domain-containing demethylases Jmjd3 and UTX increased the H3K27me3 conten

179 xpression of the histone 3 lysine 27 (H3K27) demethylase Jumonji d3 (Jmjd3), which thereby controls t

180 we were able to simultaneously delete Lysine Demethylase (KDM) 5A, 5B and 5C efficiently in vitro and

181 ant proportion affecting genes of the lysine demethylase (KDM) family.

182 eries of potent JmjC histone N-methyl lysine demethylase (KDM) inhibitors which bind to Fe(II) in the

183 succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, and citr

184 H ICD, RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the enhancers

185 Here, we identified the lysine-specific demethylase KDM1A as a novel interaction partner of ZEB2

186 Recently, we showed that lysine demethylase KDM1A is overexpressed in GBM.

187 at each promoter via recruitment of histone demethylase KDM1A.

188 (DAC), histone deacetylases (Depsi), histone demethylases (KDM1A inhibitor S2101), and histone methyl

189 lysis of chromatin recognition by the lysine demethylase KDM2A.

190 is highly potent towards the histone lysine demethylases KDM2A/7A.

191 Here, we identified histone demethylase KDM2B as a critical regulator of definitive

192 acts with the estrogen receptor (ER)/histone demethylase KDM3A (JHDM2a) complex, which modifies KDM3A

193 Here we identified that lysine demethylase KDM3A as a critical regulator of ovarian can

194 Here we identified that the lysine-specific demethylase KDM3A played a dual role in breast cancer ce

195 hway in Ewing Sarcoma, involving the histone demethylase KDM3A, previously identified by our laborato

196 in epigenetic regulators such as the lysine demethylase KDM4.

197 In conditions where the histone demethylase KDM4A is depleted or inactive, H3K9me3 accum

198 Up-regulation of the histone demethylase KDM4A promotes transient site-specific copy

199 with JIB-04, an inhibitor of the H3K9/36me3 demethylase KDM4A, restored H3K36me3 levels and sensitiv

200 Here we report that histone demethylase KDM4A/JMJD2A, which is involved in the regul

201 etermined that the hypoxia-inducible histone demethylase KDM4B is expressed in approximately 60% of E

202 ffect appeared to be mediated by the histone demethylase KDM4C (Figure 4D).

203 3) through ectopic expression of the H3K9me3 demethylase Kdm4d greatly improves SCNT embryo developme

204 Here we show that histone H3 lysine 9 demethylase Kdm4d regulates DNA replication in eukaryoti

205 this issue, Gong et al. identify the histone demethylase KDM5A as a critical editor of the cells' "hi

206 we report the identification of the histone demethylase KDM5A as a key regulator of the bromodomain

207 s between the Sin3/HDAC complex, the H3K4me3 demethylase KDM5A, GATAD1, and EMSY.

208 expression of CDK inhibitors and the histone demethylase KDM5A.

209 moval of broad H3K4me3 domains by the lysine demethylases KDM5A and KDM5B is required for normal zygo

210 2984 also promoted the expansion of the H3K4 demethylase KDM5B (also known as JARID1B)-positive subpo

211 The H3K4 demethylase KDM5B is amplified and overexpressed in lumi

212 stone lysine 4 tri-methyl (H3K4me3)-specific demethylase KDM5C occupies many active enhancers, includ

213 onstrated an essential role for the H3K27me3 demethylase KDM6A in generating a balanced alveolar comp

214 More mutations in the histone lysine demethylase KDM6A were present in non-invasive tumors fr

215 ncers show TF-dependent binding of the H3K27 demethylase KDM6A.

216 In contrast, knockdown of the H3K27 demethylases Kdm6A and Kdm6B restored the levels of H3K2

217 pregulate, and are dependent on, the histone demethylases KDM6A/B.

218 one of which encodes the histone H3K36(me2) demethylase Kdm8.

219 The JmjC histone demethylases (KDMs) are linked to tumour cell proliferat

220 Histone lysine demethylases (KDMs) are of critical importance in the ep

221 lysine methyltransferases (KMTs) and lysine demethylases (KDMs) have been implicated in the differen

222 rotein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in the regula

223 Histone lysine methyltransferases (KMTs) and demethylases (KDMs) underpin gene regulation.

224 nterest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the ge

225 system, the tetrahydrofolate-dependent aryl demethylase LigM from Sphingomonas paucimobilis, a bacte

226 Lysine demethylase 4C (KDM4C), an H3K9me3 demethylase, localizes predominantly to H3K4me3-containi

227 We found that the mRNA level of H3K4me2 demethylase LSD/KDM1, spr-5, was significantly reduced i

228 ions of epigenetic enzymes including histone demethylase LSD1 and histone acetyltransferase Tip60.

229 n of hepatic autophagy by recruiting histone demethylase LSD1 in response to a late fed-state hormone

230 cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice.

231 The lysine (K)-specific demethylase (LSD1) family of histone demethylases regula

232 which H3 dimethylated on lysine 4 (H3K4me2) demethylase LSD2 plus synthetic modules with competing a

233 ews on the inhibition of the lysine-specific demethylases (LSDs or KDM1s) and JmjC families of N-meth

234 Besides as an H3K4 demethylase, lysine-specific demethylase-1 (LSD1) has be

235 rosstalk at enhancers between the UTX (H3K27 demethylase)-MLL4 (H3K4 methyltransferase) complex and t

236 MP4 reduced histone methylases and increased demethylases mRNAs in cultured skin epithelial cells.

237 We further show that in UTX H3K27 histone demethylase mutant embryos, these genes are even more sl

238 ctions directly or indirectly as an arginine demethylase of G3BP1 that promotes SG formation.

239 promotes the recruitment of LSD1, a histone demethylase of histone 3 lysine 4 di-methylation (H3K4me

240 In the absence of the demethylase of lysine 9 of histone 3 (IBM1), a subset of

241 Given the role of FTO as a demethylase of N6-methyladenosine (m6A), we went on to p

242 cer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N(6)-methyladenosin

243 t gene expression through inhibiting histone demethylases, orthologous mutations to those known to ca

244 genetic reprogramming of TICs by the histone demethylase PHF2, which promotes their differentiation a

245 The histone demethylase PHF8 has been implicated in multiple patholo

246 Histone demethylase PHF8 is upregulated and plays oncogenic role

247 re we report that the KDM3 family of histone demethylases plays an important role in tumorigenic pote

248 Here we show that FTO, as an m(6)A demethylase, plays a critical oncogenic role in acute my

249 A, a histone H3 lysine 9 (H3K9) mono- and di-demethylase, plays a pivotal role in anoikis induction.

250 Here, we describe pyocyanin demethylase (PodA), a hitherto uncharacterized protein t

251 Reduction of function of the demethylases potently suppresses longevity and UPR(mt) i

252 istence of bona fide N(omega)-methylarginine demethylases (RDMs) is controversial.

253 demonstration that a Jumonji-domain histone demethylase regulates cellular processes required for pe

254 pecific demethylase (LSD1) family of histone demethylases regulates chromatin structure and the trans

255 ed and erased by N(6)-methyltransferases and demethylases regulates gene expression and cell fate.

256 1 (lysine-specific demethylase 1), a histone demethylase, regulates brown adipocyte metabolism in two

257 of Fe(II)- and alpha-ketoglutarate-dependent demethylases remove methyl groups from tri- and dimethyl

258 ransferases add a methyl group to mRNA while demethylases remove methyl groups.

259 The KDM5 family of histone demethylases removes the H3K4 tri-methylation (H3K4me3)

260 d2, the sole H3K4 methyltransferase and H3K4 demethylase, respectively, in S. cerevisiae.

261 tion of m(6)A methyltransferases or an m(6)A demethylase, respectively, increases or decreases infect

262 esis, through depletion of the dKDM5 histone demethylase, results in the temporal deregulation of mei

263 of the transgene d35S::LUC, although the DNA demethylase ROS1 is also required for d35S::LUC anti-sil

264 the KDM4 (JMJD2) and KDM5 (JARID1) subfamily demethylases, selectivity over representative exemplars

265 omplex (DCC) subunit DPY-21 define a Jumonji demethylase subfamily that converts H4K20me2 to H4K20me1

266 rast, JIB-04 (a pan-inhibitor of the Jumonji demethylase superfamily) had the opposite effect and was

267 ngly, there are a variety of associated aryl demethylase systems that vary in complexity.

268 ime, act as inhibitors of the sterol 14alpha-demethylase (T. cruzi CYP51) enzyme.

269 RLY FLOWERING 6 (REF6), a plant-unique H3K27 demethylase, targets genomic loci containing a CTCTGYTY

270 ion of LSD1 in AD and FTD."LSD1 is a histone demethylase that plays many roles during development.

271 S3 encodes a putative Jumonji C-type histone demethylase that regulates expression of other VRS genes

272 thaliana protein atALKBH9B (At2g17970) is a demethylase that removes m(6)A from single-stranded RNA

273 Inhibition of two of the demethylases that act specifically on histone H3K36me2,3

274 ntrols m(6)A includes methyltransferases and demethylases that add or remove this modification, as we

275 JARID1 proteins are histone demethylases that both regulate normal cell fates during

276 we found that histone methyltransferases and demethylases that regulate the trimethylation of H3K27 (

277 ased on a novel ether hydrolase enzyme, DNAN demethylase (that requires no cofactors), from a Nocardi

278 es P450 CYP51 and CYP5218 are sterol 14alpha-demethylase (the target of azole antifungals) and a puta

279 tion, as catalysed by two families of lysine demethylases (the flavin-dependent KDM1 enzymes and the

280 s (the m(6)A 'readers'), but also removed by demethylases (the m(6)A 'erasers').

281 entify a new targeting mechanism of an H3K27 demethylase to counteract Polycomb-mediated gene silenci

282 s indicate that JMJ27 functions as a histone demethylase to modulate both physiological (defense) and

283 uencing in HEK293T cells by using engineered demethylases to remove base methylations and a highly pr

284 KG-dependent dioxygenases, including histone demethylases, to cause broad histone hypermethylation.

285 ) from (and concomitant recruitment of H3K27 demethylase ubiquitously transcribed tetratricopeptide r

286 In contrast, knockdown of the H3K27 demethylase ubiquitously transcribed tetratricopeptide r

287 n mutations in the X-linked histone H3K27me3 demethylase ubiquitously transcribed X (UTX) chromosome,

288 Histone demethylase upregulation has been observed in human canc

289 Here, we show that the H3K27 demethylase UTX (also called KDM6A) is required for the

290 The X chromosome-encoded histone demethylase UTX (also known as KDM6A) mediates removal o

291 The demethylase UTX is essential for development and tissue

292 Here we found that the H3K27me3 histone demethylase UTX was an essential cell-intrinsic factor t

293 2 (PRC2), and identify the conserved histone demethylase UTX-1 as a crucial GLP-1/Notch target facili

294 and activity of the histone 3 Lys27 (H3K27) demethylase UTX/KDM6A.

295 utations in an X-linked histone H3 lysine 27 demethylase (UTX/KDM6A) or a H3 lysine 4 methylase (KMT2

296 ferent histone lysine methyltransferases and demethylases, we identified JMJD2B/KDM4B as a p53-induci

297 led that VRS3 encodes a putative histone Lys demethylase with a conserved zinc finger and Jumonji C a

298 PHF8 is a histone demethylase with specificity for repressive modification

299 a precise balance of methyltransferases and demethylases within cells determines H3K27me3 levels.

300 to the processivity of methyltransferases or demethylases, yet discordant methylation patterns have a