ライフサイエンスコーパス: demethylate

1 much of the remainder of the genome is being demethylated.

2 e to activate Bril when the promoter becomes demethylated.

3 essential PRC2 subunit, upon HBx expression demethylate a CpG dinucleotide located adjacent to NF-ka

4 in all models, underpinned by the failure to demethylate a small group of TS cell genes.

5 logous expression of ArsI conferred MAs(III)-demethylating activity and MAs(III) resistance to an ars

6 s a 5-methylcytosine dioxygenase and its DNA demethylating activity has been implicated in pluripoten

7 om de novo methylation and whether an active demethylating activity is involved.

8 llular toxicity of 5-azacytidine and its DNA demethylating activity were strongly reduced after hENT1

9 was likely caused by the inhibition of H3K4 demethylating activity, as hypoxia still increased H3K4m

10 ry regions of pluripotency genes that become demethylated after OSKM induction.

11 ng growth factor beta (TGF-beta) cytokine, a demethylating agent (5-azacytidine), B cell receptor eng

12 st (VDA) nor an HDAC inhibitor (HDACI) nor a demethylating agent (DAC) individually could optimally u

13 Treatment of A2780/cp70 with the demethylating agent 2-deoxy-5'-azacytidine induces resen

14 omoters of these genes; furthermore, the DNA demethylating agent 5 aza-2'deoxycytidine (5-Aza-dC) ant

15 In glioma cells, treatment with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-Aza-dC) wa

16 he HER4-negative BT20 cell line with the DNA demethylating agent 5-aza-2'-deoxycytidine (DAC)-enhance

17 either alone or in combination with the DNA-demethylating agent 5-aza-2'-deoxycytidine (DAC).

18 apitulated or enhanced by treatment with the demethylating agent 5-aza-2'-deoxycytidine as well as by

19 Melanoma cell lines treated with the demethylating agent 5-AZA-2'-deoxycytidine reexpressed I

20 and UM-UC13), and exposure to the chromatin demethylating agent 5-aza-2'-deoxycytidine restored HSPA

21 -type mouse fibroblasts treated with the DNA demethylating agent 5-aza-2'-deoxycytidine.

22 also expressed after treatment with the DNA demethylating agent 5-aza-2'-deoxycytidine.

23 upon continued exposure to AH or by the DNA demethylating agent 5-aza-2'-deoxycytidine.

24 f T-24 bladder cancer cell line with the DNA demethylating agent 5-aza-2'-deoxycytidine.

25 arcinogen-transformed HBECs treated with the demethylating agent 5-aza-2'deoxycytidine revealed miR-1

26 Furthermore, the DNA demethylating agent 5-aza-2-deoxycytidine failed to upre

27 Ha, CaSki, and HeLa cells and treatment with demethylating agent 5-aza-2-deoxycytidine restored DOC2B

28 DNA-demethylating agent 5-Aza-2dC significantly restored the

29 recapitulated by a co-treatment with the DNA-demethylating agent 5-Aza-C and retinoic acid across var

30 treatment of humanized NSG mice with the DNA-demethylating agent 5-aza-cytidine distinctly enhanced t

31 In response to the chemotherapeutic and DNA-demethylating agent 5-aza-deoxycytidine (5-aza-dC), tran

32 Treatment with demethylating agent 5-aza-deoxycytidine and/or histone d

33 broblasts to nanomolar concentrations of the demethylating agent 5-azacytidine increased basal expres

34 ion of the silenced allele by either the DNA demethylating agent 5-azadeoxycytidine or the SIRT1 inhi

35 Treatment with the DNA demethylating agent 5-deoxy-azacytidine does not increas

36 f the offspring because treatment with a DNA-demethylating agent alleviated exacerbation of allergic

37 Pure GuaUre-dR was found to be an effective demethylating agent and was able to induce 5azaC-dR type

38 lenic marginal zone lymphoma cell lines to a demethylating agent caused partial reversion of the High

39 treatment of a heterozygous cell line with a demethylating agent further increased the allelic expres

40 version of an adult cell by exposing it to a demethylating agent immediately followed by differentiat

41 Treatment of IDH mutant gliomaspheres with a demethylating agent partially restores insulator functio

42 Treatment with a DNA-demethylating agent restored BVES expression in CRC cell

43 o a combination of hypoxia, TGF-beta1, and a demethylating agent results in NK cells that express kil

44 ne deacetylase inhibitor entinostat with the demethylating agent vidaza profoundly affected growth of

45 we examined the therapeutic potential of the demethylating agent, 5'-aza-2'-deoxycytidine.

46 he CHS response in mice treated with the DNA demethylating agent, 5-aza-2'-deoxycytidine, after UVB e

47 l re-expression of ER was achieved using the demethylating agent, 5-azacytidine, and the HDAC inhibit

48 nografts were treated with decitabine, a DNA demethylating agent, and cytarabine, a frontline cytotox

49 ol on Ddo expression, treatment with the DNA-demethylating agent, azacitidine, causes increased mRNA

50 By treating neoplastic LGLs with a demethylating agent, IL-6-mediated SOCS3 expression was

51 eactivation by 5-aza-2'-deoxycytidine, a DNA demethylating agent, show that DNA methylation occurring

52 Combining DNA-demethylating agents (DNA methyltransferase inhibitors [

53 However, the use of DNA-demethylating agents (e.g. 5-aza-2'-deoxycytidine (5aza-

54 derstanding the anti-tumor mechanisms of DNA-demethylating agents and highlight the MDA5/MAVS/IRF7 pa

55 n cancer cells, but not normal cells, by DNA-demethylating agents and histone deacetylase inhibitors

56 if so, novel therapeutic strategies such as demethylating agents and probiotic adjuncts, particularl

57 garding the advantage of aerosol delivery of demethylating agents and the concept of priming tumors f

58 DNA demethylating agents are approved for some blood maligna

59 ound that the endothelial cells treated with demethylating agents could significantly increase the ex

60 tic lesions justifies efforts to develop DNA demethylating agents for therapeutic benefit.

61 DNA-demethylating agents have shown clinical anti-tumor effi

62 view, we discuss the clinical development of demethylating agents in hematology, with a focus on azac

63 The potential role of demethylating agents in the management of this patient p

64 leukemic LGL survival, and suggest a role of demethylating agents in the treatment of this disorder.

65 ulmonary carcinogenesis and suggest that DNA demethylating agents may be useful for activating miR-48

66 These demethylating agents may induce T-cell attraction and en

67 addition, treatment of these leukemias with demethylating agents restored the C/EBPalpha-C/EBPgamma

68 In mice, demethylating agents reversed cyclophosphamide-induced b

69 Studies show that demethylating agents strongly upregulate the expression

70 zone lymphoma and optimize therapy by using demethylating agents to reverse the high-methylation phe

71 Furthermore, both demethylating agents were found to synergize with the FA

72 Combining DNA-demethylating agents with compounds, such as DZNep, that

73 We examined the effects of 2 demethylating agents, 5-azacytidine and decitabine on gr

74 gene expression is induced by treatment with demethylating agents, may identify novel genes with tumo

75 ls caution against the indiscriminate use of demethylating agents, such as 5-aza-2'-deoxycytidine (5-

76 at were upregulated after treatment with DNA demethylating agents, such as Azacytidine and several na

77 cell lines and inducing resensitizaton with demethylating agents, we aimed to identify consistent me

78 RMS biopsies and could be reactivated by DNA-demethylating agents.

79 al specimens and functionally verified using demethylating agents.

80 erapeutic options such as Syk inhibitors and demethylating agents.

81 rtunity for treatment of SONFH patients with demethylating agents.

82 gene, Ogg1, could be reversed by the use of demethylating agents.

83 e of Chl breakdown, in vitro, but MES16 also demethylated an FCC.

84 s at putative regulatory regions that are CG-demethylated and activated in the adult brain and that C

85 We found that Ment was gradually demethylated and overexpressed during tumor progression

86 Here, we show that some TEs are demethylated and transcriptionally reactivated during an

87 ents were up-regulated in U251MG cells after demethylating and IFN-gamma treatments, suggesting an ef

88 d to the MMP13 promoter when the -104 CpG is demethylated, and confirmed this binding by chromatin im

89 3 gene in the persisting iT reg cells was as demethylated as the corresponding sequence of naturally

90 e nucleolar rRNA genes are nearly completely demethylated at promoter CGs, whereas silenced genes are

91 CpG dinucleotide in the Slp promoter that is demethylated at puberty.

92 uction, Helios(-) FOXP3(+) nTreg clones were demethylated at the FOXP3 Treg-specific demethylated reg

93 rograms at naive-associated genes and became demethylated at the loci of classically defined effector

94 Mature moDC-expanded nTregs were highly demethylated at the Treg-specific demethylation region w

95 The lysine specific demethylase 1 (LSD1) demethylates at both of these lysine residues and has be

96 he activities of Hg(II) methylating and MeHg demethylating bacteria.

97 Increased levels of demethylated beta-cell-derived DNA in the bloodstream ac

98 s question and determine that <2% of regions demethylated by 5-Aza-CdR treatment assume an open confi

99 In this assay methylated peptides are first demethylated by a KDM, and a protein methyltransferase (

100 Moreover, we find that m(6)Am is selectively demethylated by fat mass and obesity-associated protein

101 erally a transcriptional repression mark, is demethylated by H3K9-specific demethylases, leading to t

102 then targeted two proteins whose genes were demethylated by RG108-estrogen receptor 1 (ESR1) and cyc

103 pigenetic mark for gene silencing and can be demethylated by the JmjC domain of UTX.

104 onse to toll-like receptor ligands, TRAF6 is demethylated by the Jumonji domain protein JMJD6.

105 we found that histone H3 lysines 4 and 9 are demethylated by the lysine-specific demethylase, LSD1 an

106 -resorcin[5 and 6]arenes were quantitatively demethylated by treatment with BBr3 to obtain the corres

107 , respectively), it is also found to 14alpha-demethylate C4-dimethylated lanosterol (V(max) = 0.9 min

108 With the demethylated c8-ring and with c10- and c11-rings, the de

109 The lack of a demethylating capacity may have contributed to the robus

110 hl breakdown in Arabidopsis and specifically demethylates Chl catabolites at the level of FCCs in the

111 hritis and systemic lupus erythematosus were demethylated compared to healthy controls and favoured p

112 mice and suggests roles for Tet proteins in demethylating conserved gene enhancers during the phylot

113 xon and TSS200 and a dominant pattern of age-demethylated CpGs at other gene regions, and by overwhel

114 atterns over gene regions for methylated and demethylated CpGs both relate to reduced gene activity d

115 Intriguingly, demethylated CpGs downstream from SALL4 TSS are within b

116 its oxidized derivatives, at the majority of demethylated CpGs, are converted to unmodified cytosines

117 of relevance to the report that selenoneine demethylates CysHgMe, thereby providing a mechanism for

118 CD8 T cells while key effector genes remain demethylated, demonstrating that memory T cells arise fr

119 nomes of the HCT116 cell line and its highly demethylated derivative, DKO1.

120 nfected individuals, CCR5 cis-regions remain demethylated, despite restoration of CD4+ counts (>/=800

121 MJD5 (also called KDM8) has been reported to demethylate dimethylated Lys-36 in histone H3 (H3K36me2)

122 cted circulating copies of beta cell-derived demethylated DNA in serum of mice by quantitative PCR.

123 thylation (5hmC) suggested a simple means of demethylating DNA and activating genes.

124 therapy against this cancer, we used the DNA demethylating drug 5-aza-2'-deoxycytidine (DAC) in an ag

125 rs, and treatment of the cell lines with the demethylating drug 5-aza-2'-deoxycytidine resulted in in

126 The DNA-demethylating drug 5-Aza-2-deoxycytidine (5-azadC) induc

127 Here we show that treatment with the DNA-demethylating drug 5-Aza-deoxycytidine (AZA) restores hi

128 s issue, Weber and coworkers report that DNA-demethylating drugs alter the transcriptional expression

129 Early successes have been made with DNA-demethylating drugs in hematologic malignancies, and eff

130 was detectable for only 2 weeks, whereas DNA-demethylating drugs induced permanent epigenetic reprogr

131 over time after treatment with HDACi or DNA-demethylating drugs.

132 lf-renewing conditions but were subsequently demethylated during differentiation.

133 regions, and CpG shores were preferentially demethylated during erythropoiesis.

134 transcription initiation, but how H3K4me3 is demethylated during gene repression is poorly understood

135 ethylated in stem cells and gradually became demethylated during normal B-cell differentiation, sugge

136 , hox genes) is methylated, but the loci are demethylated during zygotic cleavage stages to precisely

137 protein expression correlate with the highly demethylated EBV type III latency program permissive for

138 Phosphatidylcholine (PC) bilayers were demethylated either by substitution with phosphatidyleth

139 cally, we found that miR-29b targets the DNA-demethylating enzyme, TET1, for downregulation resulting

140 ment leads to the aberrant expression of DNA demethylating enzymes and locus-specific changes to DNA

141 Surprisingly, in demethylated ESC cultures carrying mutations of DNA meth

142 ne in postmitotic neurons is to functionally demethylate expressed gene bodies while retaining the ro

143 H3K27ac) are more prominent at regions that demethylate faster.

144 y in urine therefore represents a mixture of demethylated fish-derived MeHg and amalgam-derived inorg

145 asil, which explains the accumulation of 7-O-demethylated flavone nevadensin.

146 ites examined, the -104 CpG was consistently demethylated following treatment of human articular chon

147 Herein, we report the first synthesis of a demethylated form of cholesterol (18,19-di-nor-cholester

148 electively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.

149 Pyrroline-carboxy-lysine (Pcl) is a demethylated form of pyrrolysine that is generated by th

150 ALKBH5 demethylates FOXM1 nascent transcripts, leading to enhan

151 d a higher proportion of CD4(+) T cells with demethylated Foxp3 and a specific expansion of CD4(+) CD

152 Irrespective of a fully demethylated FOXP3 locus, Tregs of subjects with dAIH ar

153 CD127CD25CD45RA Treg cells had a stable TSDR demethylated FOXP3 phenotype after expansion whereas CD4

154 In epiblast cells, TET1 demethylates gene promoters via hydroxymethylation and m

155 TET2 and EBNA2 function cooperatively to demethylate genes important for EBV-driven B-cell growth

156 ignaling pathways, whereas those enriched in demethylated genes after decitabine treatment included p

157 The number of demethylated genes was greater (P < 0.05) in tumor biops

158 n of many gene promoters and upregulation of demethylated germline genes.

159 iana endosperm that are regulated by the DNA-demethylating glycosylase DEMETER, the DNA methyltransfe

160 with core cardiac transcription factors and demethylates H3K27 residues in cardiac genes.

161 er molecular analyses demonstrate that JMJD3 demethylates H3K27me3 along the gene bodies, paving the

162 JD3 activates bivalent gene transcription by demethylating H3K27me3 and promoting transcriptional elo

163 D5 (now renamed KDM8), a JmjC family member, demethylates H3K36me2 and is required for cell cycle pro

164 Here, we show that KDM5B, which demethylates H3K4, is important for ES cell differentiat

165 y identifies a crucial function for KDM5A in demethylating H3K4 to allow ZMYND8-NuRD to operate withi

166 a, does not have the intrinsic capability to demethylate H3K4me2.

167 In this study, we show that KDM5B, which demethylates H3K4me3, plays an integral role in regulati

168 of KDM4A-D histone demethylases selectively demethylates H3K9 and H3K36 and is implicated in key cel

169 interactions, and in the second role, JMJD1A demethylates H3K9 di-methylation.

170 PHF8 demethylates H3K9me1, H3K9me2 and sustains H3K4me3 to pr

171 LSD1 demethylates HIF1alpha at lysine (K) 391, which protects

172 Hundreds of genes were demethylated highlighted by the reexpression of polycomb

173 ethylase 1) and Lid (little imaginal discs), demethylate histone H3 at Lys 4 (H3K4), a residue whose

174 specific demethylase 1 (LSD1; ref. 5), which demethylates histone H3 on Lys 4 or Lys 9 (H3K4/K9), is

175 (lysine [K]-specific demethylase 5A), which demethylates histone H3 on Lys4 (H3K4), as a pRB-interac

176 e-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an

177 ulate cellular processes by hydroxylating or demethylating histone and non-histone targets.

178 breast cancer cell invasion and apoptosis by demethylating histone and the non-histone protein p53, r

179 tones, indicating that this HDM is unable to demethylate histones during steady-state conditions.

180 Pectin methylesterases (PMEs) demethylate homogalacturonan (HG), and the majority of H

181 that inflammasome-related genes are rapidly demethylated in both monocyte-to-macrophage differentiat

182 Dnmt3b activity, the majority of which were demethylated in Dnmt3b-/- lymphomas, but not in Dnmt3b-/

183 The TSDR is selectively demethylated in ex vivo Tregs purified from secondary ly

184 , the Pdcd1 regulatory region was completely demethylated in exhausted CD8(+) T cells and remained un

185 These sequences are, however, demethylated in Foxp3(+) Treg by mechanisms as yet unkno

186 e, also upregulated in HBV-mediated HCCs, is demethylated in liver tumors at CpG dinucleotides flanki

187 rich Foxp3 intronic cis-element specifically demethylated in mature Tregs, helps maintain immune home

188 enhancer region at -5.8 kb was significantly demethylated in OA samples compared with control samples

189 In summary, the -104 CpG is demethylated in osteoarthritic cartilage, correlating wi

190 P-responsive element site, was significantly demethylated in patient-derived compared with normal con

191 er the first recombination step were largely demethylated in pro-, pre-, and mature B cells.

192 ggested that the paternal genome is actively demethylated in the zygote while the maternal genome und

193 We found increased levels of demethylated insulin DNA in subjects with new-onset type

194 as identified from an environmental MAs(III)-demethylating isolate, Bacillus sp. MD1.

195 The enzyme demethylated its natural substrate eburicol and the plan

196 TET1 binds and demethylates its own promoter and the promoter of homeob

197 sterase PME-1 limits the activity of PP2A by demethylating its catalytic subunit.

198 An additional class of demethylated loci mapped to Alu elements across the geno

199 At actively demethylated loci, 5mCs were processed to unmodified cyt

200 These enzymes demethylate lysine residues in histones in a methylation

201 FTO preferentially demethylates m(6)Am rather than N(6)-methyladenosine (m(

202 The observation that AlkB can demethylate m6A in vitro suggests a role for AlkB in reg

203 encodes the ArsI C-As lyase, S. putrefaciens demethylated MAs(III) to As(III).

204 (1)H and (13)C NMR of both EAPB0203 and its demethylated metabolite (EAPB0202) to the corresponding

205 -specific demethylase 1, also known as KDM1) demethylates mono- and dimethylated H3K4 in peptide subs

206 y important roles in gene expression through demethylating mono-, di-, or trimethylated lysines.

207 ation assays, which demonstrated that HR can demethylate monomethylated or dimethylated histone H3 ly

208 A methylation, we examined IAP expression in demethylated mouse embryonic stem cells (mESCs) and epib

209 resents a molecular switch as methylated and demethylated MTA1 nucleate NuRD or NURF complexes with o

210 is required for the NuRD repressor complex, demethylated MTA1 recognizes the bivalent histone H3K4-A

211 s pretreatment with Escherichia coli AlkB to demethylate N(1)-methyladenosine (m(1)A), N(3)-methylcyt

212 FTO demethylates N6-methyladenosine, a potential regulatory

213 y of dioxygenases have a general function in demethylating nucleic acids.

214 Lysine-specific demethylase 1 (LSD1) demethylates nucleosomal histone H3 lysine 4 (H3K4) resi

215 requires the corepressor protein, CoREST, to demethylate nucleosome substrates.

216 n within the FOXP3 locus that is selectively demethylated only in bona fide Tregs (Treg-specific deme

217 which uncovered hundreds of loci that became demethylated only when hENT1-mediated transport was acti

218 mediated stimulation of Sox2 expression, and demethylating p53 protein and consequently, modulating i

219 thylation, KDM3A promotes chemoresistance by demethylating p53.

220 These demethylated PC anions fragment upon ion trap collision-

221 Subsequent collisional activation of the demethylated PC anions produces abundant fatty acid carb

222 intenance of PD-1 surface expression and the demethylated PD-1 promoter were not a result of residual

223 n increased accumulation of less stretchable demethylated pectin in the apical wall, whereas MeSA did

224 hen exposed to TAC and maintenance of a TSDR demethylated phenotype following in vitro expansion.

225 s CD4CD127CD25CD45RA Treg cell lost the TSDR demethylated phenotype.

226 MPPs commit to pre-B cells, a predominantly demethylating phenotype ensues, with 79% of the 2966 dif

227 L-Dopa also enhanced demethylated PP2A amounts in the liver.

228 In contrast, demethylated PP2A is preferentially distributed in non-r

229 ctivation leads to substantial reductions in demethylated PP2A.

230 yl-l-methionine, the transmethylation of the demethylated precursor of vitamin K is strictly dependen

231 emethylation is occurring in the culture and demethylates preferentially the lighter Hg isotopes of M

232 adenosylmethionine (SAM), and increasing the demethylated product S-adenosylhomocysteine (SAH).

233 successive N-demethylation of the IPU mono-N-demethylated product.

234 e cleavage of the urea side chain of the IPU demethylated products; a distinct aniline dioxygenase ge

235 8 T cells identified effector molecules with demethylated promoters and poised for expression.

236 Our results indicate that only a minority of demethylated promoters are associated with nucleosome re

237 l type and silent in the other tend to share demethylated promoters, while methylation differences be

238 en peroxide in addition to the corresponding demethylated protein.

239 Recombinant CYP82E4, CYP82E5v2, and CYP82E10 demethylated (R)-nicotine 3-, 10-, and 10-fold faster th

240 se 1 (LSD1) upregulates hypoxia responses by demethylating RACK1 protein, a component of hypoxia-indu

241 -1/0 pituitary cells with a combination of a demethylating reagent and a histone deacetylase inhibito

242 were treated with 5-aza-2'-deoxycytidine, a demethylating reagent.

243 by epigenetic analysis of the Treg-specific demethylated region (TSDR) and the frequency of the IFN-

244 of demethylation of the Foxp3 Treg-specific demethylated region (TSDR) in circulating CD4(+) T cells

245 epigenetic differences in the Treg-specific demethylated region (TSDR) of Foxp3 and were more stable

246 Demethylation analysis of the Treg-specific demethylated region (TSDR) provides a more accurate asso

247 n, or methylation state of the Treg-specific demethylated region (TSDR) within the FOXP3 locus associ

248 NA methylation analyses of the Treg-specific demethylated region (TSDR) within the FOXP3 locus.

249 ds on DNA demethylation at the Treg-specific demethylated region (TSDR), a conserved, CpG-rich region

250 hin the FOXP3 gene, called the Treg-specific demethylated region (TSDR), is considered the hallmark o

251 d by a completely demethylated Treg-specific demethylated region and showed alloantigen-specific supp

252 methylated regulatory T cell (Treg)-specific demethylated region Foxp3 gene are considered natural Tr

253 3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg-specific dem

254 By using demethylation of the Treg-specific demethylated region in the FOXP3 gene as a marker for nT

255 thylation-specific PCR using a Treg-specific demethylated region in the FOXP3 gene.

256 cells with a demethylated Treg-cell-specific demethylated region in the Foxp3 locus downregulated Fox

257 cells retained a demethylated Treg-specific demethylated region in the FOXP3 promoter, maintained ac

258 Assessment of regulatory T cell-specific demethylated region methylation status in 1-month biopsy

259 with lower methylation at the Treg-specific demethylated region of the FOXP3 gene.

260 s a predominantly demethylated Treg-specific demethylated region of the FOXP3 locus.

261 rying highly demethylated Treg cell-specific demethylated region that configures committed Tregs stab

262 th a strong methylation of the Treg-specific demethylated region within the Foxp3 locus.

263 hylation of the CpG islands in Treg-specific demethylated region, CTLA-4 exon 2, and glucocorticoid-i

264 were demethylated at the FOXP3 Treg-specific demethylated region, indicative of Treg lineage stabilit

265 lated only in bona fide Tregs (Treg-specific demethylated region, TSDR) represents a reliable method

266 ated region in the FOXP3 gene (Treg-specific demethylated region, TSDR).

267 HD showed a fully demethylated Treg-specific-demethylated region.

268 enhanced demethylation of the Treg-specific demethylated region.

269 ion factors, are frequently localized in the demethylated regions of the promoters of numerous ripeni

270 at demethylation may cause regain of PRC2 in demethylated regions.

271 +)CD127(-)FOXP3(+) T cells with a persistent demethylated regulatory T cell (Treg)-specific demethyla

272 Besides a localization tendency to DNA demethylating sites, MBD3 experiences a concurrent trans

273 pre-programmed elements, and implicate their demethylated state in the maintenance of open chromatin

274 The maintenance of methylated or demethylated states of some genes in the adult brain by

275 ts also maintained their effector-associated demethylated status but acquired TEM-associated programs

276 panded with TAC, the marked loss of the TSDR demethylated status highlights the potential for loss of

277 ing the first two years of flooding, and net demethylating systems afterward.

278 ing important biomarker classes, such as C10 demethylated terpanes, alphaalphaalpha-steranes, and mon

279 xpression of COX-2, suggesting an ability to demethylate the promoter.

280 and the Msk1 kinase, which can respectively demethylate the repressive H3K9me3 mark and phosphorylat

281 cate the presence of an enzyme activity that demethylates the C13(2)-carboxymethyl group present at t

282 DME demethylates the maternal MEDEA (MEA) promoter in endosp

283 e levels of H3K56me3, suggesting that dKDM4A demethylates this heterochromatic mark to facilitate rep

284 r elements that are evolutionarily young are demethylated to a milder extent compared to older elemen

285 ctivation at specific target genes after DNA demethylating treatment in cancer cells.

286 the Helios-positive subset, carrying highly demethylated Treg cell-specific demethylated region that

287 Treg cells with a demethylated Treg-cell-specific demethylated region in t

288 (-) nTreg were characterized by a completely demethylated Treg-specific demethylated region and showe

289 Remaining FOXP3+ cells retained a demethylated Treg-specific demethylated region in the FO

290 T cells (Tconv), and possess a predominantly demethylated Treg-specific demethylated region of the FO

291 olated Treg cells during GVHD showed a fully demethylated Treg-specific-demethylated region.

292 n 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3

293 found that JMJD3 and KIAA1718 collaborate to demethylate trimethylated H3K27 (H3K27me3) on a subset o

294 mosome, germline-specific genes) only become demethylated upon entry of PGCs into the gonads.

295 These genes encode enzymes that demethylate (UTX, JARID1C) or methylate (SETD2) key lysi

296 n 5,168 CpGs (39% age-methylated and 61% age-demethylated) which were characterized by high concentra

297 thoxy-substituted benzo[c]phenanthrenes were demethylated with BBr3 and oxidized to the o-quinones wi

298 genome-wide significance of FWER <0.05, 86% demethylated with increasing age.

299 We hypothesize that fish-derived MeHg is demethylated within the body, causing mass-dependent fra

300 on of adipogenesis and osteoblastogenesis by demethylating Wnt10a gene and upregulating its expressio