ライフサイエンスコーパス: demyelinating lesion

1 acid (ACPD), was therefore injected into the demyelinating lesion.

2 injected with lysolecithin to induce a local demyelinating lesion.

3 s the effects of a single acute inflammatory demyelinating lesion.

4 early axonal pathology outside inflammatory demyelinating lesions.

5 R4.1 immunoreactivity is retained or lost in demyelinating lesions.

6 es at the rim of chronic active white matter demyelinating lesions.

7 reactive astrocytes in both rodent and human demyelinating lesions.

8 ursor cells with the distinct environment of demyelinating lesions.

9 the maturation of OPCs that are recruited to demyelinating lesions.

10 ons support using MTR to monitor symptomatic demyelinating lesions.

11 rocytes and Schwann cells, and recovery from demyelinating lesions.

12 ver-ground locomotion in the adult rat using demyelinating lesions.

13 ises the regenerative response to subsequent demyelinating lesions.

14 ukin (IL)-18 and IFN-gamma were expressed in demyelinating lesions.

15 ed mononuclear phagocytes in and adjacent to demyelinating lesions.

16 EV was found predominantly on macrophages in demyelinating lesions.

17 lized with viral RNA and was associated with demyelinating lesions.

18 4AP) can sometimes cause ectopic activity in demyelinating lesions.

19 All presented with cerebral demyelinating lesions and gadolinium enhancement.

20 osaminoglycan hyaluronan (HA) accumulates in demyelinating lesions and has been implicated in the fai

21 We determined that PH20 is elevated in demyelinating lesions and that increased PH20 expression

22 ation and neuropathology in inflammatory and demyelinating lesions, and reduced paralysis in a mouse

23 loped neither neuropathological symptoms nor demyelinating lesions, and SJL P1-Tg mice developed sign

24 is (MS), axonal injury precedes inflammatory demyelinating lesions, and the distribution of axonal da

25 r Th cells that can drive the development of demyelinating lesions are phenotypically diverse or aris

26 croglia and foamy macrophages present within demyelinating lesions as well as in perivascular infiltr

27 ltiple sclerosis (MS), who showed at least 1 demyelinating lesion at the same cord level.

28 ocal source of these molecules around active demyelinating lesions, but not chronic plaques.

29 dicate that BDNF may play a role following a demyelinating lesion by regulating the numbers of progen

30 Local increases in BMPs at the site of a demyelinating lesion causes upregulation of gliosis, gli

31 of CPS by making unilateral electrolytic or demyelinating lesions centered on the spinothalamic trac

32 s delayed significantly in response to focal demyelinating lesions compared with wild-type animals.

33 S autoimmunity characterized by inflammatory demyelinating lesions confined to optic nerves and spina

34 sulfate proteoglycans (CSPGs) accumulate at demyelinating lesions creating a nonpermissive environme

35 ies and 32 autopsies that contained actively demyelinating lesions defined by stringent criteria.

36 hite matter, immediately beyond the actively demyelinating lesion edge.

37 We tested the hypothesis that OPCs in demyelinating lesions express a specific hyaluronidase,

38 Previous focal demyelinating lesions followed by recovery did not resul

39 prevented motor and sensory dysfunction and demyelinating lesion formation.

40 onounced acute axonal damage in inflammatory demyelinating lesions from children compared to adults.

41 on myelin-laden macrophages in eight active demyelinating lesions from four autopsied multiple scler

42 ination were identical among multiple active demyelinating lesions from the same individual, but diff

43 d dorsal column of adult rats in which focal demyelinating lesions had been produced using ethidium b

44 oligodendrocyte differentiation following a demyelinating lesion, however, the endogenous sources of

45 pable of myelinating axons, are preserved in demyelinating lesions; however, why these precursors do

46 e B cells in vivo increased fourfold after a demyelinating lesion in corpus callosum, indicating that

47 This neurotoxicant induces a demyelinating lesion in the corpus callosum that is reve

48 Demyelinating lesions in Abo mice showed virus-specific

49 TSC was increased inside demyelinating lesions in both groups of patients, wherea

50 yelin formation, but their role in repair of demyelinating lesions in diseases such as multiple scler

51 tients with unusual symptoms associated with demyelinating lesions in extrapontine locations.

52 these macrophages to extensive inflammatory demyelinating lesions in infected SHP-1-deficient mice.

53 omyelitis (TMEV-DA) virus induces persistent demyelinating lesions in mice and serves as a model for

54 ling is activated in oligodendrocytes within demyelinating lesions in multiple sclerosis and EAE.

55 Eosinophils are abundant in inflammatory demyelinating lesions in neuromyelitis optica (NMO).

56 We now report actively demyelinating lesions in patients with multiple sclerosi

57 MEV but receiving no RCA I, had inflammatory demyelinating lesions in the anterior/lateral funiculi.

58 ignificantly higher viral loads and apparent demyelinating lesions in the central nerve system (CNS)

59 us (TMEV), results in immune system-mediated demyelinating lesions in the central nervous system (CNS

60 nges associated with individual inflammatory demyelinating lesions in the optic nerve.

61 transplantation into experimentally induced demyelinating lesions in the rat spinal cord.

62 ave been detected in the vicinity of the CNS demyelinating lesions in these animals.

63 Demyelinating lesions induced by intraspinal injection o

64 Focal demyelinating lesions induced in cerebral cortices of IL

65 s to infiltrating T cells and macrophages in demyelinating lesions, it is also possible that astrocyt

66 ter cuprizone treatment, suggesting that the demyelinating lesion itself elicits a decrease in BDNF.

67 ntrols, we examined the relationship between demyelinating lesion load in three volumes of the cerebr

68 system (CNS) characterized by inflammatory, demyelinating lesions localized in the brain and spinal

69 rian degeneration of axons transected in the demyelinating lesions makes a major contribution to the

70 Other less common mechanism being demyelinating lesion, mass effect, infection, hemorrhage

71 Acute optic neuritis due to an inflammatory demyelinating lesion of the optic nerve is often seen in

72 Furthermore, in the demyelinating lesions of multiple sclerosis, CD44 expres

73 ells in perivascular cuffs and inflammatory, demyelinating lesions of SJL mice chronically infected w

74 drocyte progenitor cells (OPCs) recruited to demyelinating lesions often fail to mature into oligoden

75 y should be considered for acute tumefactive demyelinating lesions only once criteria of disseminatio

76 ssion in healthy control brain in all active demyelinating lesions, remyelinated lesions, and peripla

77 ia consisted of the presence of early active demyelinating lesions--required for immunopattern classi

78 e plus photon irradiation producing discrete demyelinating lesions sufficient to stop axonal conducti

79 t and topography of OG destruction in active demyelinating lesions suggests that in subsets of multip

80 neoplasms, abscesses, lymphomas, tumefactive demyelinating lesions (TDLs), or encephalitis.

81 aptic morphological abnormality secondary to demyelinating lesions that are in an anatomically linked

82 e the roles BDNF may play in the repair of a demyelinating lesion, the cuprizone model was used and t

83 oligodendrocytes during the progression of a demyelinating lesion to a chronic state and determined w

84 ats with focal dorsal column inflammatory or demyelinating lesions to determine whether DTI measures

85 ptimal spatiotemporal positioning of OPCs in demyelinating lesions to receive local proliferative and

86 lt in selective localization of inflammatory demyelinating lesions to the optic nerves and spinal cor

87 ied to identify and characterize the primary demyelinating lesion, using a variety of histological an

88 Importantly, in adults, remyelination of demyelinating lesions was also accelerated, at the expen

89 enters the spinal cord and colocalizes with demyelinating lesions, we used ultrasmall superparamagne

90 Mouse and human demyelinating lesions were assessed for hyaluronidase ex

91 ith early-stage multiple sclerosis, cortical demyelinating lesions were frequent, inflammatory, and s

92 Demyelinating lesions were induced in the rat spinal dor

93 Demyelinating lesions were not centered on the injection

94 T cells and demyelinating lesions were observed in the CNS at a late

95 d do not mature into myelin-forming cells in demyelinating lesions where HMW hyaluronan is present.

96 ng ages, including acute and chronic, active demyelinating lesions with macrophages and lymphocytic p

97 junction or within the gray matter, causing demyelinating lesions within cortical areas.

98 ar syndrome) and at least two characteristic demyelinating lesions within the brain were randomized t