ライフサイエンスコーパス: denervation

1 occurred in 15 patients with severe baseline denervation.

2 y ganglia, we avoided widespread sympathetic denervation.

3 ssed in regenerating blastemas but lost upon denervation.

4 e of wild-type mice after surgically induced denervation.

5 nt levels of activated caspase-3 but limited denervation.

6 Ns) preceded by neuromuscular junction (NMJ) denervation.

7 in nonballoon denervation but not in balloon denervation.

8 vated muscle and suppressed following muscle denervation.

9 ology and clinical significance of sudomotor denervation.

10 in all walking conditions were evident after denervation.

11 ients who underwent left cardiac sympathetic denervation.

12 ntrolling the levels of AChR mRNAs following denervation.

13 resulting in a progressive and severe muscle denervation.

14 dissection, edema, or thrombus) by OCT after denervation.

15 e taken before and 1-2 weeks following SO-LG denervation.

16 hosphorylation is sustained during long-term denervation.

17 ulate AChR beta-subunit mRNAs in response to denervation.

18 eting eligibility requirements could undergo denervation.

19 of significant caudate nucleus dopaminergic denervation.

20 unt for changes in AChR expression following denervation.

21 eduction with percutaneous renal sympathetic denervation.

22 ue muscle fiber-type or secondary to chronic denervation.

23 als that follow SC processes extended during denervation.

24 on's disease-like nigrostriatal dopaminergic denervation.

25 f miRNA expression maximized at 7 days after denervation.

26 ate the levels of Fn14 in skeletal muscle on denervation.

27 onomic dysfunction including parasympathetic denervation.

28 ction depends on the length of the period of denervation.

29 ical inhibition significantly delayed muscle denervation.

30 naptic adaptation resulting from striatal DA denervation.

31 d Fn14-KO mice compared to wild-type mice on denervation.

32 and attenuates skeletal muscle atrophy upon denervation.

33 d neuromuscular fragmentation and occasional denervation.

34 he blood-pressure-lowering efficacy of renal denervation.

35 ritical atrial regions responsible for vagal denervation.

36 d molecular analyses revealed no evidence of denervation.

37 tral auditory system after profound cochlear denervation.

38 polar voltages varied widely within areas of denervation (0.8 mV [Q1-Q3, 0.3-1.7 mV] and 4.0 mV [Q1-Q

39 was used to quantify myocardial sympathetic denervation ((11)C-meta-hydroxyephedrine [(11)C-HED]), p

40 alue of EAT thickness on cardiac sympathetic denervation ((123)I-MIBG early and late heart:mediastinu

41 l ablation sites were abnormally innervated (denervation/(123)I-mIBG transition zone in 50% each).

42 oping SCA had greater amounts of sympathetic denervation (33 +/- 10% vs. 26 +/- 11% of LV; p = 0.001)

43 did not affect muscle wasting in response to denervation, a condition in which autophagy is blocked,

44 With 80-99% denervation, a persistent aberrant signal develops in D2

45 o determine the effect of pulmonary arterial denervation acute pulmonary hypertension was induced in

46 evaluate the effectiveness of radiofrequency denervation added to a standardized exercise program for

47 he blood pressure-lowering efficacy of renal denervation added to a standardized stepped-care antihyp

48 ), and the sham subjects who did not undergo denervation after 6 months (non-crossover group).

49 ation group, the sham subjects who underwent denervation after the 6-month endpoint (crossover group)

50 n 25 (4%) patients, left cardiac sympathetic denervation alone in 18 (3%) patients, and combination t

51 Denervation also causes the activation of ERK1/2, JNK1/2

52 6-OHDA-induced splenic denervation also prevented ultrasound-induced protection

53 Bilateral renal denervation also reduced inflammation, as reflected by d

54 ervation maps demonstrated areas of complete denervation and (123)I-mIBG transition zone in all patie

55 in several conditions, including functional denervation and aging.

56 ive motor neuron loss, gait problems, muscle denervation and atrophy, paralysis, and have diminished

57 terventional approaches, transcatheter renal denervation and baroreflex activation therapy, are used

58 twork was abrogated by carotid chemoreceptor denervation and by pharmacological blockade of either sy

59 ns for resistant hypertension, such as renal denervation and carotid barostimulation, are under inves

60 in pain intensity between the radiofrequency denervation and control groups at 3 months was -0.18 (95

61 ximately 50%) but not different in the renal denervation and control groups.

62 ion of miR-29b attenuates atrophy induced by denervation and immobilization.

63 ndependent mechanisms depending on degree of denervation and macroscopic morphology of the lesion.

64 observed in disease models, contributing to denervation and motoneuron dysfunction.

65 ts, progressive neuromuscular junction (NMJ) denervation and pre-synaptic build-up of mutant GlyRS.

66 with the earliest detectable signs of muscle denervation and preceded physiologically measurable moto

67 ations occurring in response to dopaminergic denervation and pulsatile administration of L-DOPA.

68 ve treatment were not different in the renal denervation and the control groups, respectively (P=0.36

69 We then focused on denervation and we revealed that changes in transcripts

70 us contributing to axon degeneration, muscle denervation, and motor neuron cell death in SMA.

71 Electromyography shows denervation, and patients often report that early sympto

72 ations on electromyography indicating active denervation, and reduced compound muscle action potentia

73 le atrophy, an increase in muscle mass after denervation, and reorganization of motor endplates at th

74 ration, and diaphragm neuromuscular junction denervation, and resulted in reduced functional diaphrag

75 h as flecainide and left cardiac sympathetic denervation are not well validated.

76 clinical studies have identified sympathetic denervation as a predictor of increased arrhythmia susce

77 known to activate HuR, was induced following denervation as a result of MKK3/6 activation and a decre

78 We expressed global and regional LV denervation as the percentage extent of z score severity

79 e intervention group received radiofrequency denervation as well.

80 wasted, with highly atrophied type 1 fibers, denervation at most synaptic sites, induction of "fetal"

81 B blockade in rats with stable nigrostriatal denervation attenuated the forelimb akinesia improvement

82 gehog signaling in normal touch domes, while denervation attenuates touch dome-derived tumors.

83 to recover the force lost due to the partial denervation because motor unit size did not change.

84 scular ultrasound was observed in nonballoon denervation but not in balloon denervation.

85 G93A) ALS mice delays neuromuscular junction denervation by inducing axonal sprouting and enhancing m

86 with dissection was higher in balloon-based denervation catheters.

87 Carotid body denervation (CBD) causes hypoventilation and increases t

88 zed by the International Cardiac Sympathetic Denervation Collaborative Group.

89 nts, or intervertebral disks, radiofrequency denervation combined with a standardized exercise progra

90 inical models we proposed that noradrenergic denervation contributes to the impairment of response in

91 t PSC functions would be altered even before denervation, contributing to NMJ malfunctions.

92 Cardiac sympathetic denervation (CSD) has been shown to reduce the burden of

93 Carotid sinus nerve denervation (CSD) has recently been shown to relieve hyp

94 ve previously shown that carotid sinus nerve denervation (CSD) reduces arterial blood pressure (ABP)

95 mice also exhibited evidence of bone marrow denervation, demonstrating a loss of neurofilament-200 s

96 levels in the fibers of atrophic muscles via denervation-dependent and -independent mechanisms.

97 pear to act, at least in part, by inhibiting denervation-dependent induction of Myog and Gdf5 gene ex

98 l uptake had no interval change; 3 with mild denervation developed interval decline in lateral and in

99 es under wasting conditions such as fasting, denervation, diabetes, and cancer cachexia.

100 Denervation diminishes overall genomic DNA methylation a

101 e investigated the slower atrophy induced by denervation (disuse).

102 y processing recover after profound cochlear denervation due to a progressive, compensatory plasticit

103 Similar denervation efficacy was found when RDN was performed di

104 nd 48 of 101 non-crossover subjects; 6-month denervation follow-up was available for 93 of 101 crosso

105 red immediately or after 4 months of chronic denervation, followed by administration of Herceptin or

106 difference between the groups favoured renal denervation for 3-month change in both office and 24-h b

107 sed in numerous studies to document regional denervation for arrhythmic event risk assessment.

108 61 procedures with selective peripheral denervation for cervical dystonia were retrospectively a

109 The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressu

110 med the safety but not the efficacy of renal denervation for treatment-resistant hypertension at 6 mo

111 Cortical cholinergic denervation frequency increased monotonically with incre

112 utonomic nervous system by renal sympathetic denervation, ganglionated plexi ablation, ganglion stell

113 n the 23 paired PET scans, worsening cardiac denervation (global diff-SEP > 9) occurred in 14 of 23 (

114 e in 24-h heart rate was -1.4 +/- 7.4 in the denervation group and -1.3 +/- 7.3 in the sham group; (9

115 lood pressure was -6.75+/-15.11 mm Hg in the denervation group and -4.79+/-17.25 mm Hg in the sham-pr

116 atory SBP changed -6.8 +/- 15.1 mm Hg in the denervation group and -4.8 +/- 17.3 mm Hg in the sham gr

117 ippers converted to dippers was 21.2% in the denervation group and 15.0% in the sham group (95% CI: -

118 at 6 months was -14.13+/-23.93 mm Hg in the denervation group as compared with -11.74+/-25.94 mm Hg

119 th SYMPLICITY HTN-3 results for the original denervation group, the sham subjects who underwent dener

120 Instead, there was clear evidence that denervation had a long-term effect on the limb microvasc

121 The lower tertiles of sympathetic denervation had SCA rates of 1.2%/year and 2.2%/year, wh

122 Beyond blood pressure, renal denervation has been shown to improve glucose tolerance,

123 Renal sympathetic denervation has been shown to reduce office blood pressu

124 of radiofrequency-derived sympathetic renal denervation has not been studied over time and may provi

125 s that control skeletal muscle atrophy after denervation have been established, the transcriptome in

126 Prior studies of catheter-based renal artery denervation have not systematically performed ambulatory

127 Renal sympathetic denervation holds promise for future indications in hype

128 Direct mechanical denervation impairs heart regeneration in neonatal mice,

129 ent studies have shown that pulmonary artery denervation improves pulmonary hemodynamics in an experi

130 was used in 24% and left cardiac sympathetic denervation in 8%.

131 fective at preventing neuromuscular junction denervation in a mutant SOD1(G93A) mouse model of amyotr

132 ssociated with hair follicles following skin denervation in adult mice and, remarkably, become re-ass

133 was examined in vivo in a model of chemical denervation in adult rats.

134 Bone growth and remodeling is inhibited by denervation in adults and children, resulting in alterat

135 tate between normal innervation and complete denervation in advanced disease.

136 of vascular injury was observed after renal denervation in all systems; however, different patterns

137 Despite the importance of NMJ denervation in ALS, the mechanisms involved remain unexp

138 nter to expectation, we found no evidence of denervation in either model, but junctions in both model

139 erview of heretofore generated data on renal denervation in experimental models, in human hypertensio

140 ented the pathological evidence of sudomotor denervation in FAP.

141 reased EAT thickness and cardiac sympathetic denervation in heart failure.

142 ect regional patterns of cardiac sympathetic denervation in idiopathic Parkinson disease (IPD) using

143 satisfaction after left cardiac sympathetic denervation in LQTS or catecholaminergic polymorphic ven

144 hogenesis and time course of parasympathetic denervation in Parkinson's disease is limited and would

145 and night periods compared with sham (Renal Denervation in Patients With Uncontrolled Hypertension [

146 (Renal Denervation in Patients With Uncontrolled Hypertension [

147 Results of the SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension)

148 estigated RTM in the SYMPLICITY HTN-3 (Renal Denervation in Patients With Uncontrolled Hypertension)

149 rst specific quantification of noradrenergic denervation in PD patients in vivo.

150 nological changes after radiofrequency-renal denervation in the swine model.

151 s DAergic neuron demise and striatal DAergic denervation in vivo against PD-causing toxins in a Nurr1

152 rimental baroreflex dysfunction (sino-aortic denervation) in rats and mice.

153 Indications for left cardiac sympathetic denervation included beta-blocker intolerance (15; 32%)

154 We also observed that denervation increased expression of the RNA-binding prot

155 Previous work showed that muscle denervation increases expression of AChR mRNAs due to tr

156 We show that denervation increases expression of the RNA-binding prot

157 that pathological muscle conditions such as denervation induce alterations in exosomal miR profile w

158 rom controls in terms of size, resistance to denervation-induced atrophy, and force.

159 dult muscle induces hypertrophy and prevents denervation-induced atrophy.

160 ddition, antiprogestins RU 38486 blunted the denervation-induced decrease in mRNA levels of TGF-beta

161 ation in the barrel cortex due to peripheral denervation-induced plasticity.

162 nant human TGF-beta1 (rhTGF-beta1) prevented denervation-induced reduction of BMD further supporting

163 To explore the relation between denervation-induced reduction of bone formation and TGF-

164 f BMD further supporting our hypothesis that denervation-induced reduction of bone formation is a res

165 These results suggest that denervation-induced reduction of bone formation may be r

166 14 (Fn14) system is a critical regulator of denervation-induced skeletal muscle atrophy.

167 nd desmin filaments were intact at 7 d after denervation, inducing the dissociation of desmin filamen

168 Splenic denervation interrupts the anti-inflammatory neural arc,

169 Radiofrequency denervation is a commonly used treatment for chronic low

170 Muscle denervation is a convenient model to examine expression

171 Cortical cholinergic denervation is a major neurodegeneration associated with

172 Renal denervation is a new interventional approach to treat hy

173 Renal denervation is a new treatment considered for several po

174 Renal denervation is also being evaluated for treatment of var

175 Autonomic denervation is an alternative approach for patients with

176 To determine whether denervation is caused directly by the virus or indirectl

177 Some of the AChR loss that follows denervation is correlated with failure of portions of th

178 bers, precedes wasting of mutant soleus; (3) denervation is likely to drive this wasting, and (4) the

179 We proposed left cardiac sympathetic denervation (LCSD) as useful additional therapy, but evi

180 riate predictors of SCA were PET sympathetic denervation, left ventricular end-diastolic volume index

181 I found that progressive denervation may alter DA signaling by three independent

182 We conclude that, in rats, CB denervation may not produce CCR plasticity.

183 Strategies aimed at preventing or delaying denervation may therefore be of benefit in ALS.

184 the transient hypoventilation elicited by CB denervation means that these afferents are active under

185 enal artery wall injury with relation to the denervation method is unknown.

186 shows decreased survival, paralysis, muscle denervation, motor neuron loss, anxiety-like behavior, a

187 sion, we measured mRNA levels of TGF-beta in denervation mouse bone and found decreased mRNA levels o

188 Moreover, both lines displayed denervation muscle atrophy and age-dependent loss of mot

189 nd in sheep at 2 weeks after bilateral renal denervation (n = 10/group).

190 80 patients were randomly assigned to renal denervation (n=38) or sham control (n=42) and followed u

191 Muscle degeneration, denervation, neuromuscular [neuromuscular junction (NMJ)

192 Because NMJ denervation occurs early in the process and that perisyn

193 he neuromuscular junction, where significant denervation occurs prior to motor neuron degeneration.

194 Sensory denervation of a genetically engineered mouse model of P

195 decline of neurological impairment, delayed denervation of hindlimb muscles, and prolonged survival

196 Surgical denervation of iBAT reduced cold-induced brown adipogene

197 efore, represent a marker of parasympathetic denervation of internal organs, but further validation s

198 Furthermore, denervation of mouse muscle injected with a luciferase r

199 After denervation of mouse tibialis anterior muscles, phosphor

200 dult onset progressive motor neuron loss and denervation of neuromuscular junctions.

201 efore degeneration of ventral root axons and denervation of NMJs.

202 urgical removal of the periosteum, capsaicin denervation of sensory nerves or knockdown in vivo of th

203 Denervation of skeletal muscle has been previously used

204 Synaptic pathology and denervation of target muscle fibers has been reported pr

205 We hypothesized that denervation of the CB (CBD) chemoreceptors would reduce

206 e of fully regenerating amputated limbs, but denervation of the limb inhibits the formation of the po

207 Moreover, prior denervation of the liver abolished the improved counterr

208 Denervation of the neuromuscular junction (NMJ) precedes

209 discrete brain regions, we hypothesized that denervation of the PMV or lesioning spinal afferents wou

210 Denervation of the posterior tongue eliminated, and its

211 uced by vasoconstriction, and to demonstrate denervation of the pulmonary artery at a histological le

212 Denervation of the skin impairs cutaneous healing, prese

213 's disease leads to progressive dopaminergic denervation of the striatum, impairing the function of c

214 y inhibition accelerated early neuromuscular denervation of the tibialis anterior muscle and the onse

215 Pulmonary artery denervation offers the possibility of a new treatment op

216 he effect of radiofrequency pulmonary artery denervation on acute pulmonary hypertension induced by v

217 ur study was to evaluate the effect of renal denervation on blood pressure in the absence of antihype

218 s, fasciculations, hyperreflexia, and active denervation on electromyography without cerebellar ataxi

219 id not demonstrate a benefit of renal artery denervation on reduction in ambulatory BP in either the

220 investigated the acute repercussion of renal denervation on the renal arteries of patients treated wi

221 current analysis details the effect of renal denervation or a sham procedure on ABPM measurements 6 m

222 mly assigned in a 2:1 ratio to undergo renal denervation or a sham procedure.

223 paB activation is important for atrophy upon denervation or cancer.

224 l exercise training regimen in humans and to denervation or clenbuterol treatment in rodents.

225 ced myofibril disassembly and degradation on denervation or fasting.

226 ctive thermogenic state, whereas sympathetic denervation or glucocorticoid administration promotes mo

227 ated deficits in forelimb akinesia, striatal denervation or loss of SNpc neuron, nor did STN DBS elev

228 tients to reoperation with either additional denervation or pallidal stimulation.

229 nt hypertension were randomized 2:1 to renal denervation or sham control.

230 iography and were randomly assigned to renal denervation or sham control.

231 Eligible subjects were randomized 2:1 to denervation or sham procedure.

232 ration of rAAV:Fst to muscles at the time of denervation or tenotomy did not prevent subsequent muscl

233 -limb musculature of mice two weeks prior to denervation or tenotomy promoted muscle hypertrophy that

234 hypoxia (10 and 12% FiO2), after sino-aortic denervation, or during isoflurane anesthesia.

235 carcely known cell population, and show that denervation- or deprivation-derived plasticity is expres

236 rs a new approach to objective assessment of denervation over short timescales in MND and enables inv

237 dity resulting from left cardiac sympathetic denervation, patients with LQTS and CPVT have high level

238 extent < 30%), and 22 had moderate to severe denervation (percentage extent > 30%, z score </= 2.5 SD

239 ents had normal (11)C-HED PET, 5 showed mild denervation (percentage extent < 30%), and 22 had modera

240 pine 10 mg/d were randomly assigned to renal denervation plus standardized stepped-care antihypertens

241 Regardless of adherence to treatment, renal denervation plus standardized stepped-care antihypertens

242 Renal denervation prevented these effects of hypertension on D

243 Finally, bilateral iBAT denervation prevents the glucoregulatory effect of MC4R(

244 580 treatment protected skeletal muscle from denervation prior to its effects on microglial cells.

245 atterns is important for refinement of renal denervation procedures.

246 yephedrine ((11)C-HED) PET and determine the denervation rate over 2 y.

247 Renal denervation (RDN) can reduce renal and whole-body sympat

248 applying catheter-based radiofrequency renal denervation (RDN) demonstrated a favorable safety profil

249 The therapeutic potential of renal denervation (RDN) for arrhythmias has not been fully exp

250 her insulin sensitivity improved after renal denervation (RDN) for resistant hypertension.

251 Catheter-based renal denervation (RDN) is currently under development for the

252 sized that inhibiting the SNS by using renal denervation (RDN) will improve insulin sensitivity (SI)

253 een proposed to explain nonresponse to renal denervation (RDN).

254 ure and function following renal sympathetic denervation (RDN).

255 e suggested that catheter-based renal-artery denervation reduces blood pressure in patients with resi

256 ing innervation stays anatomically coherent, denervation reduces phasic variations in extracellular D

257 Left cardiac sympathetic denervation reduces risk in long-QT syndrome (LQTS) and

258 ate regions showed synaptic remodelling with denervation-reinnervation events.

259 n of ephrin-A3 on fast myofibers followed by denervation/reinnervation promotes their respecification

260 Selective peripheral denervation remains a surgical option in the treatment o

261 Studies of renal denervation report disparate results.

262 il breakdown normally observed at 14 d after denervation required not only dissociation of desmin fil

263 Denervation resulted in a marked increase in miR-206 and

264 Trigeminal denervation resulted in epithelial defects with or witho

265 Pulmonary artery denervation resulted in reduced mean pulmonary artery pr

266 Muscle denervation resulting from injury, disease or aging resu

267 axons in the sciatic nerve suggest that this denervation results from disturbances of axonal transpor

268 Skin denervation reveals that renewal of touch dome stem cell

269 ed the effects of radiofrequency renal nerve denervation (RF-RDN) on the pathobiology of HF and the i

270 During the period of denervation, SCs at the NMJ extend elaborate processes f

271 .05) and greatest discrepancies between post denervation SO fascicle and MTU length changes occurred.

272 ry nerve grew progressively weaker following denervation, sound-evoked activity in the cortex-and, to

273 Previous randomised renal denervation studies did not show consistent efficacy in

274 mation of sources and magnitude of biases in denervation studies.

275 month follow-up was available for 319 of 361 denervation subjects and 48 of 101 non-crossover subject

276 In denervation subjects, the 12-month office systolic BP (S

277 ated with balloon-based and nonballoon-based denervation systems by quantitative angiography, intrava

278 ied in balloon-based and in nonballoon-based denervation systems.

279 h correspondingly fewer vesicles and partial denervation that eliminates some release sites also cont

280 In arteries treated with balloon-based denervation that had dissection by OCT, the balloon/arte

281 In balloon denervation, the presence of dissections by OCT was asso

282 Deletion of Tff2 recapitulates splenic denervation to promote carcinogenesis.

283 ngs do not support the use of radiofrequency denervation to treat chronic low back pain from these so

284 Bilateral renal denervation using phenol application to the renal arteri

285 als were assigned to either pulmonary artery denervation, using a prototype radiofrequency catheter a

286 th Uncontrolled Hypertension) trial of renal denervation versus a sham procedure.

287 This muscle denervation was associated with early electrophysiologic

288 In experimental hyperdynamic sepsis, renal denervation was associated with greater hypotension and

289 Evidence of partial denervation was found in the sternomastoid but not the t

290 in both muscles until preonset (P380), while denervation was frequent in the mutant mouse.

291 Left cardiac sympathetic denervation was not uncommon although the indication was

292 Vagal denervation was performed to assess its effect on liver

293 airment scores, caudate nucleus dopaminergic denervation was relatively frequent in individuals with

294 Associative striatal dopamine denervation was significant in all PD patients.

295 st fascicle lengthening (1.5 +/- 0.8%) after denervation were found during upslope walking, where MG

296 Unilateral renal denervation, which partly attenuated blood pressure, onl

297 50 renal arteries) underwent bilateral renal denervation with 5 different systems, 3 of which balloon

298 d glucose uptake in the tongue would support denervation with subsequent reinnervation of the muscle

299 isted thoracoscopic left cardiac sympathetic denervation, with a median follow-up of 29 months (range

300 w focuses on how selective renal sympathetic denervation works, its present and potential therapeutic