ライフサイエンスコーパス: densa

1 rticles permeate extensively into the lamina densa.

2 either LN or LG domains and formed a lamina densa.

3 essed in thick ascending limb and the macula densa.

4 adjusting transport downstream of the macula densa.

5 sertion or are present throughout the lamina densa.

6 in its highly specialized role in the macula densa.

7 ls appear to insert directly into the lamina densa.

8 cells of the thick ascending limb and macula densa.

9 nding limb of Henle's loop and of the macula densa.

10 the most pronounced expression in the macula densa.

11 the cortical thick ascending limb and macula densa.

12 reactive COX-2 expression inthe cTALH/macula densa.

13 ulation of NOS1beta expression in the macula densa affects sodium excretion and salt-sensitive hypert

14 between (a) NaCl concentration at the macula densa and (b) glomerular filtration rate or glomerular c

15 lar epithelial cells located near the macula densa and associated with the renal arterioles exhibit s

16 pp38 expression, predominantly in the macula densa and cTALH.

17 morpholino-injected embryos lacked a lamina densa and lamina lucida at 24 hpf, and BM defects, such

18 primary NOS1 isoform expressed in the macula densa and regulates the tubuloglomerular feedback respon

19 tex, COX-2 expression is localized to macula densa and surrounding cortical thick ascending limb of H

20 issue separation in TBDN is below the lamina densa, and electron microscopy has revealed abnormalitie

21 d to cTALH cells in the region of the macula densa, and that dietary salt restriction increases COX-2

22 Evidence for the regulation of macula densa apical Na/H exchange by AngII was recently reporte

23 ments involves ATP release across the macula densa basolateral membrane through a maxi-anion channel.

24 esults indicate that AngII stimulates macula densa basolateral Na/H exchange via AT1 receptors and th

25 ble skin disease manifesting with sub-lamina densa blistering, erosions, and chronic ulcers.

26 i-vWFA2 autoantibodies located at the lamina densa bound to the dermal side of salt-split skin and in

27 localized to the lower lamina lucida/lamina densa by direct and indirect immunoelectron microscopy (

28 mulates COX-2 expression in cTALH and macula densa by transcriptional regulation predominantly via a

29 in glomerular tuft contractility and macula densa cell calcium handling were observed.

30 y or expression we clonally derived a macula densa cell line (MMDD1 cells) from SV-40 transgenic mice

31 ) receptor expression in the cultured macula densa cell line MMDD1.

32 Because macula densa cells also express a basolateral Na/H exchanger, t

33 Macula densa cells are renal sensor elements that detect change

34 Macula densa cells detect changes in luminal sodium chloride co

35 Macula densa cells in the distal nephron, according to the clas

36 Communication from macula densa cells to the glomerular vascular elements involves

37 kidney, the intracellular pH (pHi) of macula densa cells was measured with fluorescence microscopy us

38 l isoform of nitric oxide synthase in macula densa cells, reduces the constrictor effect of adenosine

39 Ca2+ oscillations were absent in the macula densa cells.

40 marked accumulation of elastin in the macula densa, collecting ducts, and pelvicalyceal epithelia of

41 uter medullary collecting ducts), and macula densa-containing segments.

42 mmary, these results demonstrate that macula densa COX-2 expression is oppositely regulated by AT(1)

43 Macula densa cyclooxygenase 2 (COX-2)-derived prostaglandins se

44 decreased hyperfiltration, decreased macula densa cyclooxygenase-2 expression, decreased albuminuria

45 very of fluid yet does not activate a macula densa-dependent fall in SNGFR because it blunts the TGF

46 Macula densa epithelial cells displayed bright AE2 immunostaini

47 microfibrils might be present in the lamina densa, epithelial cell cultures (WISH, HaCaT, and primar

48 thelial cells at the perimeter of the macula densa exhibit spontaneous oscillations in intracellular

49 We recently found that macula densa expresses alpha-, beta-, and gamma-splice variants

50 plants (Potamogeton diversifolius and Egeria densa), followed by toxicity testing with microcosm surf

51 2B contributes to salt absorption and macula densa function in the low NaCl concentration range.

52 oscopy is providing new insights into macula densa-glomerular signaling.

53 rane appeared to be thickened and the lamina densa had an irregular appearance after treatment with C

54 embrane, as seen by a nearly complete lamina densa, hemidesmosomes, and the polarized, linear distrib

55 resence of fibrillin-1 throughout the lamina densa in the dermal-- epidermal junction.

56 NOS1), and NOS1beta expression in the macula densa increases on a high-salt diet.

57 chloride [Cl(-)] at the level of the macula densa increases renin production and secretion, we inves

58 , the GBM is irregularly swollen, the lamina densa is absent, and permeation is increased.

59 a change in NaCl concentration at the macula densa, is likely initiated by the generation of a vasoac

60 P consumed in active transport by the macula densa leads to formation of adenosine, which causes glom

61 ause of the presence of NKCC2A in the macula densa, maximum tubuloglomerular feedback responses were

62 Macula densa (MD) cells detect changes in distal tubular sodium

63 Macula densa (MD) cells express COX-2 and COX-2-derived PGs app

64 Macula densa (MD) cells of the juxtaglomerular apparatus (JGA)

65 f) colocalize in renal tubules and in macula densa (MD) cells which modulate glomerular filtration ra

66 ronal nitric oxide synthase (nNOS) in macula densa (MD) cells, experiments were performed in anesthet

67 A were shown to be coexpressed in the macula densa (MD) segment of the mouse TAL.

68 pends on Na-K-2Cl co-transport in the macula densa (MD), but it is less clear whether Na,K-ATPase is

69 cell granules and exhibit an altered macula densa morphology.

70 cellular uptake of L-arginine limits macula densa nitric oxide generation and actions on tubuloglome

71 hich was prevented with inhibitors of macula densa nitric oxide synthase (NOS).

72 Furthermore, macula densa NO production was similar in the isolated perfused

73 I) blockers correlated with increased macula densa NOS-I immunoreactivity.

74 d SNGFR through a mechanism involving macula densa NOS.

75 utero epidermal blisters beneath the lamina densa of the basement membrane and also in renal agenesi

76 at size-dependent permeation into the lamina densa of the GBM and the podocyte glycocalyx, together w

77 rticles show that permeation into the lamina densa of the GBM is size-sensitive.

78 hat it had blunted the effects of the macula densa on SNGFR.

79 autocrine factors of endothelial and macula densa origins.

80 It also suggests that the altered macula densa phenotype is related to the activity of the renin-

81 tic plants: Azolla caroliniana Willd, Egeria densa Planch., and Myriophyllum simulans Orch.

82 dded Ag or Cu metal mass was found in Egeria densa plant tissue, with the remainder primarily in the

83 ls that were within 100 microm of the macula densa plaque using four-dimensional multiphoton microsco

84 ck ascending loop of Henle (TALH) and macula densa, providing the error signal for tubuloglomerular f

85 ing luminal NaCl concentration in the macula densa region of the nephron stimulates renin secretion,

86 changes in NaCl concentration in the macula densa region of the nephron, thereby serving as an impor

87 icited by elevations in [NaCl] in the macula densa region of the nephron.

88 cuss recent advances in understanding macula densa sensing and suggest these cells, in addition to sa

89 glomerular feedback through increased macula densa sodium and chloride delivery, leading to afferent

90 Compared with control mice, mice with macula densa-specific knockout of all nitric oxide synthase 1 i

91 ble to rescue the abnormality seen in macula densa structure.

92 The persistence of ENMs in E. densa suggests that chronic exposures, or food web trans

93 Particles traversing the lamina densa tend to accumulate upstream of the podocyte glycoc

94 ular calcium dynamics in cells of the macula densa, the observation was made that tubular epithelial

95 pt distal tubular fluid flow past the macula densa, thus minimizing tubuloglomerular feedback-depende

96 nt, Ag(0) and CuO ENMs were persistent in E. densa tissues for up to 9 and 6 months, respectively.

97 st in part, through direct effects on macula densa transport processes.

98 TEM confirmed that the lamina densa was partly or completely absent along the anterior

99 d anchoring fibril connections to the lamina densa were more numerous compared with the composite mod

100 th basement membrane proteins and the lamina densa were retained at the BMZ throughout healing.