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1 mbrane additions > 100 fF (about fifty large dense-cored vesicles).
2 rs are released from a unique organelle: the dense-core vesicle.
3 the open state of syntaxin, which then docks dense core vesicles.
4 s also exhibit enhanced peptide release from dense core vesicles.
5 dase labeling for EM-1 was enriched in large dense core vesicles.
6 re of the nonglomerular type and may contain dense core vesicles.
7 ed terminal profiles contained spherical and dense core vesicles.
8 try (MALDI-TOF MS) allow the assay of single dense core vesicles.
9 being a component of neuropeptide-containing dense core vesicles.
10 contain large amounts of spherical and a few dense core vesicles.
11 nlabeled axon terminals that often contained dense core vesicles.
12 a, but only DOR-LI was associated with large dense core vesicles.
13 containing chromogranin B, a marker of large dense core vesicles.
14 terminals and was also associated with large dense core vesicles.
15 ls that contained both small clear and large dense core vesicles.
16 filled with clear vesicles and less abundant dense core vesicles.
17 rohemal-like profiles that contain primarily dense core vesicles.
18 bpools of vesicles: small clear vesicles and dense core vesicles.
19 ffiliated with either endomembranes or large dense-core vesicles.
20 ptic vesicles and a smaller number of larger dense-core vesicles.
21 thought to mediate Ca2+-triggered fusion of dense-core vesicles.
22 immunolabeling was particularly enriched in dense-core vesicles.
23 eals a substantial decrease in the number of dense-core vesicles.
24 toplasmic compartment, often associated with dense-core vesicles.
25 -dependent manner by virtue of transport via dense-core vesicles.
26 a membranes, but neither is present on large dense-core vesicles.
27 e that NT-3 is packaged in presumptive large dense-core vesicles.
28 s intracellular, often associated with large dense-core vesicles.
29 amperometry to monitor exocytosis of single dense-core vesicles.
30 y rather than being an intrinsic property of dense-core vesicles.
31 ve terminals packed with electron-lucent and dense-core vesicles.
32 Approximately 2% of the 5-HT terminals had dense-core vesicles.
33 und, clear vesicles and a variable number of dense-core vesicles.
34 with small clear vesicles and also contained dense-core vesicles.
35 ium, which is the main mechanism to retrieve dense-core vesicles.
36 alized to the membrane of insulin-containing dense-core vesicles.
37 ts are suggested by the presence of numerous dense-cored vesicles.
38 ose contacts were smaller in size and lacked dense-cored vesicles.
39 ude small clear vesicles and two subpools of dense core vesicles, a small and a large dense core vesi
41 ned intense peroxidase labeling within large dense core vesicles along the perimeter of the axoplasm.
42 nce that CKA facilitates axonal transport of dense core vesicles and autophagosomes in a PP2A-depende
43 L-ENK may be released by exocytosis from the dense core vesicles and diffuse within the extracellular
44 types contained small clear as well as large dense core vesicles and formed heterogeneous types of sy
45 ontacts; 2) small, round vesicles plus a few dense core vesicles and forming asymmetric contacts; or
48 es, endomorphin-2 was contained primarily in dense core vesicles and MOR1 was located primarily at no
49 syt I and VII partially colocalize on large dense core vesicles and that upregulation of syt VII pro
50 eptide precursor VGF that is stored in large dense core vesicles and undergoes regulated secretion.
51 immunoreactivity was highly associated with dense core vesicles and was localized predominantly in a
52 UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, resp
53 arger swellings, which tended to contain few dense-core vesicles and a rich complement of clear round
54 e NTS contained small, clear, and some large dense-core vesicles and formed heterogeneous synaptic co
56 three ultrastructural types, with clear- or dense-core vesicles and those with a dark cytoplasm havi
57 ally contained small clear, as well as large dense-core vesicles and were often apposed to unlabeled
58 r on the density, size or shape of clear and dense-cored vesicles and 2) whether swellings with diffe
59 at both calcium-regulated exocytic vesicles (dense core vesicles) and endocytic structures (clathrin-
60 on-lucent vesicles and, occasionally, large, dense-core vesicles) and symmetrical (with small, flatte
61 s small pleomorphic vesicles, multiple large dense core vesicles, and several mitochondria, and they
62 trinsic neurons, afferent neurons containing dense core vesicles, and systems of serial synaptic comp
63 ar, spherical vesicles and a few granular or dense-core vesicles, and (4) specialization in the last
64 in neurons, are associated with synaptic and dense-core vesicles, and control vesicle acidification a
65 was associated with plasma membranes, large dense-core vesicles, and cytoplasmic surfaces of small v
66 ric synapses, contained darkly stained large dense-core vesicles, and displayed gamma-aminobutyric ac
67 ect in which a portion of synaptic vesicles, dense-core vesicles, and presynaptic cytomatrix proteins
68 3a, a small GTPase localized on membranes of dense-core vesicles, and prevents GTP-Rab3a from binding
69 re integral membrane components of the large dense-core vesicles, and that they are closely regulated
71 mata and axons revealed its association with dense-core vesicles (approximately 114 nm in diameter).
75 ne fraction consisted of rapidly sedimenting dense core vesicles associated with plasma membrane frag
79 ow that the entire transmitter contents of a dense-core vesicle can be released within a second throu
80 potential (at 24 degreesC), indicating that dense-core vesicles can exhibit a rate of exocytosis app
81 addition to being a resident on cytoplasmic dense-core vesicles, CAPS was present in clusters of app
82 st that CeIA-2 may be an important factor in dense-core vesicle cargo release with parallels to insul
86 n were defective for anterograde movement of dense-core vesicle components, including egl-3 PC2, egl-
89 d a lower frequency of synapse formation and dense-cored vesicle content than CHT-labeled profiles in
90 ry afferent synapses (C-type), synapses with dense-cored vesicles (D, mostly primary afferents), and
91 PC12 cells are used to test whether altering dense core vesicle (DCV) motion affects neuropeptide rel
92 o suggested to play a role in Ca2+-dependent dense-core vesicle (DCV) exocytosis in neuroendocrine ce
93 n at the Ca(2+)-dependent triggering step of dense-core vesicle (DCV) exocytosis in permeabilized PC1
94 cytosolic factor required for Ca2+-activated dense-core vesicle (DCV) exocytosis in permeable neuroen
97 the receptor is concentrated on peptidergic dense core vesicles (DCVs) and is notably absent from th
98 pported bilayers and purified neuroendocrine dense core vesicles (DCVs) as fusion partners, and we ex
99 ion requires anterograde axonal transport of dense core vesicles (DCVs) containing neuropeptides and
103 nctional relationships of axonal kinesins to dense core vesicles (DCVs) that were filled with a GFP-t
105 beta cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in respon
106 another form of neuronal signaling, that of dense core vesicles (DCVs), whose contents can include n
114 ned by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out
116 imaging of Drosophila and hippocampal neuron dense-core vesicles (DCVs) containing a neuropeptide or
117 ants revealed a 50% reduction in presynaptic dense-core vesicles (DCVs) corresponding to enhanced neu
118 ized distribution of neuropeptide-containing dense-core vesicles (DCVs) in Caenorhabditis elegans cho
122 n essential for the Ca2+-dependent fusion of dense-core vesicles (DCVs) with the plasma membrane and
128 rminal Ca2+ stores to regulate exocytosis of dense-cored vesicles (DCVs) and whether these stores can
129 5-HT secreted by both synaptic vesicles and dense core vesicles diffuse readily to the extrasynaptic
130 packing of peptide hormones/neuropeptides in dense-core vesicles do not necessarily require a special
131 In Caenorhabditis elegans motor neurons, dense core vesicles dock at the plasma membrane but are
132 for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle dock
137 ATP release and the number of ATP-containing dense-core vesicles docking are decreased in HD astrocyt
139 have been analyzed for biological effects on dense core vesicle exocytosis in neuroendocrine PC12 cel
141 fferent systems as follows: Ca(2+)-triggered dense core vesicle exocytosis, spontaneous synaptic vesi
142 oposed to be an important regulator of large dense-core vesicle exocytosis from neuroendocrine tissue
143 " Rab3 and Rab27, regulate late steps during dense-core vesicle exocytosis in neuroendocrine cells.
145 to play an essential role in Ca2+-regulated dense-core vesicle exocytosis in vertebrate neuroendocri
148 esynaptic UNC-31 activity, likely acting via dense-core vesicle exocytosis, is required to locally ac
154 rface with three other proteins required for dense-core vesicle exocytosis: phospholipase D1 (PLD1),
157 sible roles of the CAPS protein in mediating dense core vesicle fusion and modulating synaptic vesicl
159 on was enhanced in cell-attached patches and dense-core vesicle fusion pores had conductances that we
160 e extracellular space may be contingent upon dense-core vesicle fusion with the plasma membrane.
161 lcium entry, the calcium dependence of large dense-cored vesicle fusion under conditions of minimal s
162 nd bear varicosities that contain both large dense-core vesicles/granules (120-160 nm) and smaller cl
165 nd rab3B also increased NE uptake into large dense core vesicles in digitonin-permeabilized PC12 cell
166 h BDNF or its pro-peptide both stained large dense core vesicles in excitatory presynaptic terminals
167 in nerve terminals or the movement of large dense core vesicles in growth cones and endocrine cells.
168 le PCs that are primarily localized to large dense core vesicles in neurons and endocrine cells.
169 extracellularly applied HRP (0.1%) perturbs dense core vesicles in the synaptic processes of leech n
170 y that regulates the exocytic fusion pore of dense-core vesicles in cultured endocrine beta cells.
172 synapses nor the numbers or diameters of the dense-core vesicles in each GAL terminal changed after t
176 lay a highly specific 3-fold accumulation of dense-core vesicles in synaptic terminals, which was not
177 the buccalins (BUCs), to a single subset of dense-core vesicles in the terminals of the cholinergic
179 p between Ca2+ entry and exocytosis of large dense-cored vesicles in bovine adrenal chromaffin cells.
181 euronal terminals (which often contain large dense core vesicles) in limbic and basal forebrain regio
183 strocytes, suggesting that the exocytosis of dense-core vesicles is impaired by mHtt in HD astrocytes
187 unknown whether the molecular steps of large dense-core vesicle (LDCV) docking and priming are identi
189 een divalent cations and exocytosis of large dense-cored vesicles (LDCV) was studied with capacitance
191 isms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release
192 The release of biogenic amines from large dense core vesicles (LDCVs) depends on localization of t
193 e role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells.
194 of proteins and neurotransmitters from large dense core vesicles (LDCVs) is a highly regulated proces
196 indicate preferential localization to large dense core vesicles (LDCVs) rather than synaptic-like mi
198 eted to norepinephrine (NE)-containing large dense core vesicles (LDCVs) when stably expressed in PC1
202 itters fall into two distinct classes, large dense-core vesicles (LDCVs) and small synaptic vesicles,
203 eins depends on their inclusion within large dense-core vesicles (LDCVs) capable of regulated exocyto
204 the function of syb in the docking of large dense-core vesicles (LDCVs) in live PC12 cells using tot
205 presence of estrogen receptor-alpha on large dense-core vesicles (LDCVs) in the hippocampus suggests
206 bly, we found that TRPV1 is present in large dense-core vesicles (LDCVs) that were mobilized to the n
207 cells, VMAT2 localizes exclusively to large dense-core vesicles (LDCVs), and we now show that cytopl
208 quired for release at the synapse, and large dense-core vesicles (LDCVs), which mediate extrasynaptic
213 ory organelles (synaptic-like microvesicles, dense-core vesicles, lysosomes, exosomes and ectosomes),
215 sults, this raises the possibility that some dense core vesicles may, like small synaptic vesicles, u
217 ed family member) and determined its role in dense-core vesicle-mediated peptide secretion and in syn
219 eta cells, IA-2 is an important regulator of dense core vesicle number and glucose-induced and basal
220 e of CART peptide 55-102 immunoreactivity in dense core vesicles of axon terminals suggests that the
223 is relatively enriched in the purified large dense-core vesicles of chromaffin cells and associated w
226 ve peptides are packaged as proproteins into dense core vesicles or secretory granules, where they ar
227 ter events than quanta associated with large dense-core vesicles previously recorded in vertebrate pr
228 nly in presynaptic cells and may account for dense-cored vesicles previously seen in some taste cells
232 en the ways that synaptic vesicles and large dense-core vesicles release their contents have been emp
234 , hormones and neuropeptides stored in large dense core vesicles (secretory granules) are released th
236 th full exocytotic fusion of small clear and dense core vesicles shown in previous morphometric studi
238 signal peptide-containing domain, for large dense core vesicle sorting and regulated secretion from
240 w that the presence and release of the small dense core vesicle subpool is dependent on synaptotagmin
242 l size was much less than expected for large dense core vesicles, suggesting that release originated
243 at neuronal exocytosis of neuropeptides from dense core vesicles suppressed the survival of Caenorhab
244 ficial peptide neurotransmitter containing a dense core vesicle targeting domain, a NMDA NR1 subunit
246 acts had at least one morphologically docked dense core vesicle that presumably contained peptide; th
248 a decrease in immunolabeling associated with dense-core vesicles that were near the plasma membrane a
249 ted peptide and enkephalins, are packaged in dense-core vesicles, then the LOC terminals synapsing wi
253 y the local changes of 27 proteins at single dense-core vesicles undergoing calcium-triggered fusion.
254 tained pleomorphic vesicles as well as large dense core vesicles, varied in size and formed heterogen
255 ted emission depletion microscopy imaging of dense-core vesicles, we find that fusion-generated Omega
256 ntate gyrus, although some dynorphin-labeled dense core vesicles were also observed in dendritic shaf
258 tion; (2) large immunonegative profiles with dense-core vesicles were abundant and were frequently pr
259 CRF-immunoreactive axon terminals containing dense-core vesicles were found in both the caudal dorsol
261 s, NT-LI was commonly associated with large, dense-cored vesicles, whereas D2-LI was found along the
262 S-1 is required for Ca2+-triggered fusion of dense-core vesicles with the plasma membrane, but its si
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