ライフサイエンスコーパス: dense core vesicle

1 mbrane additions > 100 fF (about fifty large dense-cored vesicles).

2 rs are released from a unique organelle: the dense-core vesicle.

3 the open state of syntaxin, which then docks dense core vesicles.

4 s also exhibit enhanced peptide release from dense core vesicles.

5 dase labeling for EM-1 was enriched in large dense core vesicles.

6 re of the nonglomerular type and may contain dense core vesicles.

7 ed terminal profiles contained spherical and dense core vesicles.

8 try (MALDI-TOF MS) allow the assay of single dense core vesicles.

9 being a component of neuropeptide-containing dense core vesicles.

10 contain large amounts of spherical and a few dense core vesicles.

11 nlabeled axon terminals that often contained dense core vesicles.

12 a, but only DOR-LI was associated with large dense core vesicles.

13 containing chromogranin B, a marker of large dense core vesicles.

14 terminals and was also associated with large dense core vesicles.

15 ls that contained both small clear and large dense core vesicles.

16 filled with clear vesicles and less abundant dense core vesicles.

17 rohemal-like profiles that contain primarily dense core vesicles.

18 R1 cooperates with EARP in the biogenesis of dense core vesicles.

19 bpools of vesicles: small clear vesicles and dense core vesicles.

20 alized to the membrane of insulin-containing dense-core vesicles.

21 ffiliated with either endomembranes or large dense-core vesicles.

22 ptic vesicles and a smaller number of larger dense-core vesicles.

23 thought to mediate Ca2+-triggered fusion of dense-core vesicles.

24 immunolabeling was particularly enriched in dense-core vesicles.

25 eals a substantial decrease in the number of dense-core vesicles.

26 toplasmic compartment, often associated with dense-core vesicles.

27 -dependent manner by virtue of transport via dense-core vesicles.

28 a membranes, but neither is present on large dense-core vesicles.

29 e that NT-3 is packaged in presumptive large dense-core vesicles.

30 s intracellular, often associated with large dense-core vesicles.

31 amperometry to monitor exocytosis of single dense-core vesicles.

32 y rather than being an intrinsic property of dense-core vesicles.

33 ve terminals packed with electron-lucent and dense-core vesicles.

34 Approximately 2% of the 5-HT terminals had dense-core vesicles.

35 und, clear vesicles and a variable number of dense-core vesicles.

36 to mimic the proneuropeptides found in large dense-core vesicles.

37 with small clear vesicles and also contained dense-core vesicles.

38 ium, which is the main mechanism to retrieve dense-core vesicles.

39 ts are suggested by the presence of numerous dense-cored vesicles.

40 ose contacts were smaller in size and lacked dense-cored vesicles.

41 ude small clear vesicles and two subpools of dense core vesicles, a small and a large dense core vesi

42 We propose that dense-core vesicle acidification controlled by the evolu

43 ned intense peroxidase labeling within large dense core vesicles along the perimeter of the axoplasm.

44 nce that CKA facilitates axonal transport of dense core vesicles and autophagosomes in a PP2A-depende

45 L-ENK may be released by exocytosis from the dense core vesicles and diffuse within the extracellular

46 types contained small clear as well as large dense core vesicles and formed heterogeneous types of sy

47 ontacts; 2) small, round vesicles plus a few dense core vesicles and forming asymmetric contacts; or

48 Here, we demonstrate that dense core vesicles and lysosomal trafficking dynamics a

49 The 5-HTi profiles were filled with dense core vesicles and made synapses.

50 es, endomorphin-2 was contained primarily in dense core vesicles and MOR1 was located primarily at no

51 syt I and VII partially colocalize on large dense core vesicles and that upregulation of syt VII pro

52 eptide precursor VGF that is stored in large dense core vesicles and undergoes regulated secretion.

53 immunoreactivity was highly associated with dense core vesicles and was localized predominantly in a

54 UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, resp

55 arger swellings, which tended to contain few dense-core vesicles and a rich complement of clear round

56 e NTS contained small, clear, and some large dense-core vesicles and formed heterogeneous synaptic co

57 Furthermore, we describe two types of dense-core vesicles and quantify a filamentous network o

58 In hippocampal area CA1, small dense-core vesicles and tethered synaptic vesicles are r

59 three ultrastructural types, with clear- or dense-core vesicles and those with a dark cytoplasm havi

60 ally contained small clear, as well as large dense-core vesicles and were often apposed to unlabeled

61 r on the density, size or shape of clear and dense-cored vesicles and 2) whether swellings with diffe

62 at both calcium-regulated exocytic vesicles (dense core vesicles) and endocytic structures (clathrin-

63 on-lucent vesicles and, occasionally, large, dense-core vesicles) and symmetrical (with small, flatte

64 post-translational processing, release from dense core vesicles, and ability to activate G-protein-c

65 s small pleomorphic vesicles, multiple large dense core vesicles, and several mitochondria, and they

66 trinsic neurons, afferent neurons containing dense core vesicles, and systems of serial synaptic comp

67 ar, spherical vesicles and a few granular or dense-core vesicles, and (4) specialization in the last

68 in neurons, are associated with synaptic and dense-core vesicles, and control vesicle acidification a

69 was associated with plasma membranes, large dense-core vesicles, and cytoplasmic surfaces of small v

70 ric synapses, contained darkly stained large dense-core vesicles, and displayed gamma-aminobutyric ac

71 ect in which a portion of synaptic vesicles, dense-core vesicles, and presynaptic cytomatrix proteins

72 3a, a small GTPase localized on membranes of dense-core vesicles, and prevents GTP-Rab3a from binding

73 re integral membrane components of the large dense-core vesicles, and that they are closely regulated

74 Labeled boutons contain dense-core vesicles, and they resemble a population of t

75 mata and axons revealed its association with dense-core vesicles (approximately 114 nm in diameter).

76 Dense-core vesicles are generated at the trans-Golgi and

77 Peptidergic dense-core vesicles are involved in packaging and releas

78 Large dense-core vesicles are unaffected by clathrin knock dow

79 Secretory granules, such as neuronal dense core vesicles, are specialized for storing cargo a

80 ne fraction consisted of rapidly sedimenting dense core vesicles associated with plasma membrane frag

81 In both cases, dense-core vesicles associated with DOR labeling were of

82 in the density of both synaptic vesicles and dense core vesicles at presynaptic terminals.

83 onserved proteins controls the maturation of dense-core vesicles at the trans-Golgi network.

84 ion with endosomes in non-neuronal cells and dense core vesicle biogenesis in iPSC-derived neurons.

85 ow that the entire transmitter contents of a dense-core vesicle can be released within a second throu

86 potential (at 24 degreesC), indicating that dense-core vesicles can exhibit a rate of exocytosis app

87 addition to being a resident on cytoplasmic dense-core vesicles, CAPS was present in clusters of app

88 st that CeIA-2 may be an important factor in dense-core vesicle cargo release with parallels to insul

89 has been shown in other systems to regulate dense-core vesicle cargo release.

90 defects in sorting soluble and transmembrane dense-core vesicle cargos.

91 Our results indicate that dense-core vesicles carry CAPS to sites of exocytosis, w

92 n were defective for anterograde movement of dense-core vesicle components, including egl-3 PC2, egl-

93 Moreover, after a CWSS, dense-core vesicles containing DOR immunoreactivity coul

94 er for acidic organelles, but unlike that of dense-core vesicles containing egg-laying hormone.

95 d a lower frequency of synapse formation and dense-cored vesicle content than CHT-labeled profiles in

96 ry afferent synapses (C-type), synapses with dense-cored vesicles (D, mostly primary afferents), and

97 PC12 cells are used to test whether altering dense core vesicle (DCV) motion affects neuropeptide rel

98 o suggested to play a role in Ca2+-dependent dense-core vesicle (DCV) exocytosis in neuroendocrine ce

99 n at the Ca(2+)-dependent triggering step of dense-core vesicle (DCV) exocytosis in permeabilized PC1

100 cytosolic factor required for Ca2+-activated dense-core vesicle (DCV) exocytosis in permeable neuroen

101 Dense-core vesicle (DCV) exocytosis is a SNARE (soluble

102 hypothesis of transmitter release applies to dense-core vesicle (DCV) secretion is unknown.

103 the receptor is concentrated on peptidergic dense core vesicles (DCVs) and is notably absent from th

104 pported bilayers and purified neuroendocrine dense core vesicles (DCVs) as fusion partners, and we ex

105 ion requires anterograde axonal transport of dense core vesicles (DCVs) containing neuropeptides and

106 tides and neurotrophic factors secreted from dense core vesicles (DCVs) control many brain functions,

107 Cmpy first delivers Gbb to dense core vesicles (DCVs) for activity-dependent releas

108 Despite a key role for dense core vesicles (DCVs) in neuronal function, there a

109 ole in the fusion of neuropeptide-containing dense core vesicles (DCVs) is unknown.

110 The dense core vesicles (DCVs) of neuroendocrine cells are a

111 nctional relationships of axonal kinesins to dense core vesicles (DCVs) that were filled with a GFP-t

112 Neurons secrete neuropeptides from dense core vesicles (DCVs) to modulate neuronal activity

113 nt of pigment dispersing factor (PDF) filled dense core vesicles (DCVs) to the terminals at the dorsa

114 ms that regulate how neuropeptide-containing dense core vesicles (DCVs) traffic along the axon, how n

115 Dense core vesicles (DCVs) transport and release various

116 Neuropeptides and neurotrophins, stored in dense core vesicles (DCVs), are together the largest cur

117 in-3 family member KIF1A-driven transport of dense core vesicles (DCVs), lysosomes, and synaptic vesi

118 beta cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in respon

119 Neuropeptides are packed into dense core vesicles (DCVs), which fuse with the plasma m

120 another form of neuronal signaling, that of dense core vesicles (DCVs), whose contents can include n

121 cargos derived from neuronal and intestinal dense core vesicles (DCVs).

122 esting the existence of a refractory pool of dense core vesicles (DCVs).

123 mbranes and often near 5-HT-containing large dense core vesicles (DCVs).

124 ess sensitive to Ca2+ than that required for dense core vesicles (DCVs).

125 eurotrophins are stored in and released from dense core vesicles (DCVs).

126 el of neuropeptide release from motor neuron dense core vesicles (DCVs).

127 Here, green fluorescent protein-tagged dense-core vesicles (DCVs) are imaged in Drosophila moto

128 Dense-core vesicles (DCVs) are regulated secretory organ

129 Dense-core vesicles (DCVs) are secretory vesicles found

130 ned by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out

131 Neuronal dense-core vesicles (DCVs) contain diverse cargo crucial

132 imaging of Drosophila and hippocampal neuron dense-core vesicles (DCVs) containing a neuropeptide or

133 Neuropeptide secretion from dense-core vesicles (DCVs) controls many brain functions

134 ants revealed a 50% reduction in presynaptic dense-core vesicles (DCVs) corresponding to enhanced neu

135 ized distribution of neuropeptide-containing dense-core vesicles (DCVs) in Caenorhabditis elegans cho

136 r neuropeptide and neurotrophin release from dense-core vesicles (DCVs) in mammalian neurons.

137 Dense-core vesicles (DCVs) in neuroendocrine cells are m

138 The secretory cycle of dense-core vesicles (DCVs) in physiologically stimulated

139 Neuropeptides released from dense-core vesicles (DCVs) modulate neuronal activity, b

140 ICANCE STATEMENT:Neuropeptide secretion from dense-core vesicles (DCVs) modulates synaptic transmissi

141 ynaptic release of neuropeptides packaged in dense-core vesicles (DCVs) regulates synapses, circuits,

142 indicating that both microvesicles (MVs) and dense-core vesicles (DCVs) undergo fusion.

143 n essential for the Ca2+-dependent fusion of dense-core vesicles (DCVs) with the plasma membrane and

144 tinct organelles-synaptic vesicles (SVs) and dense-core vesicles (DCVs), respectively.

145 ated small synaptic vesicles (SSVs) or large dense-core vesicles (DCVs).

146 nt exocytosis of synaptic vesicles (SVs) and dense-core vesicles (DCVs).

147 naptic vesicles (SVs) and neuropeptides from dense-core vesicles (DCVs).

148 phins depends on presynaptic accumulation of dense-core vesicles (DCVs).

149 enzymes, and neurotrophins by exocytosis of dense-core vesicles (DCVs).

150 store, and release neuropeptides packaged in dense-core vesicles (DCVs).

151 rminal Ca2+ stores to regulate exocytosis of dense-cored vesicles (DCVs) and whether these stores can

152 es is substantially faster than of endocrine dense core vesicles despite similar molecular machinerie

153 5-HT secreted by both synaptic vesicles and dense core vesicles diffuse readily to the extrasynaptic

154 packing of peptide hormones/neuropeptides in dense-core vesicles do not necessarily require a special

155 In Caenorhabditis elegans motor neurons, dense core vesicles dock at the plasma membrane but are

156 for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle dock

157 Here, we describe a mechanism for dense core vesicle docking in neurons.

158 CAPS function in dense core vesicle docking parallels UNC-13 in synaptic

159 for synaptic vesicles, is not essential for dense core vesicle docking.

160 taxin can bypass the requirement for CAPS in dense core vesicle docking.

161 ATP release and the number of ATP-containing dense-core vesicles docking are decreased in HD astrocyt

162 hese findings uncover the role of dynamin in dense-core vesicle endocytosis and secretory capacity.

163 PI(4,5)P2 localizes to sites of dense core vesicle exocytosis in neuroendocrine cells an

164 have been analyzed for biological effects on dense core vesicle exocytosis in neuroendocrine PC12 cel

165 Late post-docking events in dense core vesicle exocytosis in permeable PC12 cells re

166 fferent systems as follows: Ca(2+)-triggered dense core vesicle exocytosis, spontaneous synaptic vesi

167 oposed to be an important regulator of large dense-core vesicle exocytosis from neuroendocrine tissue

168 " Rab3 and Rab27, regulate late steps during dense-core vesicle exocytosis in neuroendocrine cells.

169 Ca(2+)-triggered dense-core vesicle exocytosis in PC12 cells does not req

170 to play an essential role in Ca2+-regulated dense-core vesicle exocytosis in vertebrate neuroendocri

171 Essential prefusion steps in dense-core vesicle exocytosis involve sequential ATP-dep

172 Novel assays for dense-core vesicle exocytosis were developed by expressi

173 esynaptic UNC-31 activity, likely acting via dense-core vesicle exocytosis, is required to locally ac

174 ut is generally required for and specific to dense-core vesicle exocytosis.

175 to be essential for synaptic vesicle but not dense-core vesicle exocytosis.

176 7 to examine how synaptotagmins function in dense-core vesicle exocytosis.

177 the primary determinant of Ca(2+)-triggered dense-core vesicle exocytosis.

178 Rab27/Rab3A constitutes a Rab-GEF cascade in dense-core vesicle exocytosis.

179 rface with three other proteins required for dense-core vesicle exocytosis: phospholipase D1 (PLD1),

180 een suggested to trigger exocytosis of large dense-core vesicles from neuroendocrine cells.

181 nal synapses but occurs by exocytosis of the dense-cored vesicles from axonal varicosities and acts b

182 ore and small synaptic vesicles, its role in dense-core vesicle function has received less attention

183 norhabditis elegans for mutants defective in dense-core vesicle function.

184 sible roles of the CAPS protein in mediating dense core vesicle fusion and modulating synaptic vesicl

185 osphate synthesis in the regulation of large dense-core vesicle fusion dynamics.

186 on was enhanced in cell-attached patches and dense-core vesicle fusion pores had conductances that we

187 e extracellular space may be contingent upon dense-core vesicle fusion with the plasma membrane.

188 le information on the mechanisms involved in dense-core vesicle fusion.

189 lcium entry, the calcium dependence of large dense-cored vesicle fusion under conditions of minimal s

190 nd bear varicosities that contain both large dense-core vesicles/granules (120-160 nm) and smaller cl

191 vesicles but not in insulin-containing large dense core vesicles in beta-cells.

192 rn of the spinal cord where it is located in dense core vesicles in C-fiber terminals.

193 nd rab3B also increased NE uptake into large dense core vesicles in digitonin-permeabilized PC12 cell

194 h BDNF or its pro-peptide both stained large dense core vesicles in excitatory presynaptic terminals

195 in nerve terminals or the movement of large dense core vesicles in growth cones and endocrine cells.

196 le PCs that are primarily localized to large dense core vesicles in neurons and endocrine cells.

197 e transporter implicated in the transport of dense core vesicles in neurons and the delivery of integ

198 extracellularly applied HRP (0.1%) perturbs dense core vesicles in the synaptic processes of leech n

199 Neuropeptide release from dense-core vesicles in Caenorhabditis elegans is promote

200 y that regulates the exocytic fusion pore of dense-core vesicles in cultured endocrine beta cells.

201 The parallels between dense-core vesicles in different systems suggest that si

202 synapses nor the numbers or diameters of the dense-core vesicles in each GAL terminal changed after t

203 The Ca(2+)-dependent exocytosis of dense-core vesicles in neuroendocrine cells requires a p

204 mponent for the Ca2+-dependent exocytosis of dense-core vesicles in neuroendocrine cells.

205 We found Syt IV on both micro- and dense-core vesicles in posterior pituitary nerve termina

206 lay a highly specific 3-fold accumulation of dense-core vesicles in synaptic terminals, which was not

207 the buccalins (BUCs), to a single subset of dense-core vesicles in the terminals of the cholinergic

208 Proneuropeptides are packaged into dense-core vesicles in which they are processed into act

209 p between Ca2+ entry and exocytosis of large dense-cored vesicles in bovine adrenal chromaffin cells.

210 onin gene-related peptide (CGRP) is found in dense-cored vesicles in the motor nerve terminal.

211 euronal terminals (which often contain large dense core vesicles) in limbic and basal forebrain regio

212 In sensory afferents, the number of dense core vesicles increases 5-fold, while there is onl

213 strocytes, suggesting that the exocytosis of dense-core vesicles is impaired by mHtt in HD astrocytes

214 Secretion from dense-core vesicles is reputedly much slower than that f

215 By 5 minutes, small dense-core vesicles known to transport active zone prote

216 Large dense core vesicle (LDCV) exocytosis in chromaffin cells

217 n behaving mice: a genetically encoded large dense core vesicle (LDCV) sensor that detects presynapti

218 unknown whether the molecular steps of large dense-core vesicle (LDCV) docking and priming are identi

219 The six targets include several large dense-core vesicle (LDCV) proteins, but also proteins in

220 een divalent cations and exocytosis of large dense-cored vesicles (LDCV) was studied with capacitance

221 Most neurons store peptides in large dense core vesicles (LDCVs) and release the neuropeptide

222 isms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release

223 The release of biogenic amines from large dense core vesicles (LDCVs) depends on localization of t

224 e role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells.

225 of proteins and neurotransmitters from large dense core vesicles (LDCVs) is a highly regulated proces

226 Large dense core vesicles (LDCVs) mediate the regulated releas

227 indicate preferential localization to large dense core vesicles (LDCVs) rather than synaptic-like mi

228 Neuroendocrine (NE) cells use large dense core vesicles (LDCVs) to traffic, process, store a

229 eted to norepinephrine (NE)-containing large dense core vesicles (LDCVs) when stably expressed in PC1

230 The Ca2+-activated fusion of large dense core vesicles (LDCVs) with the plasma membrane is

231 ers (VMATs) localize preferentially to large dense core vesicles (LDCVs).

232 striking association between p64H1 and large dense-core vesicles (LDCVs) and microtubules.

233 itters fall into two distinct classes, large dense-core vesicles (LDCVs) and small synaptic vesicles,

234 eins depends on their inclusion within large dense-core vesicles (LDCVs) capable of regulated exocyto

235 the function of syb in the docking of large dense-core vesicles (LDCVs) in live PC12 cells using tot

236 presence of estrogen receptor-alpha on large dense-core vesicles (LDCVs) in the hippocampus suggests

237 bly, we found that TRPV1 is present in large dense-core vesicles (LDCVs) that were mobilized to the n

238 (TEM) clearly shows that a portion of large dense-core vesicles (LDCVs) with double/multiple cores a

239 cells, VMAT2 localizes exclusively to large dense-core vesicles (LDCVs), and we now show that cytopl

240 ) are priming factors for synaptic and large dense-core vesicles (LDCVs), promoting their entry into

241 quired for release at the synapse, and large dense-core vesicles (LDCVs), which mediate extrasynaptic

242 otransmitters and peptide hormones via large dense-core vesicles (LDCVs).

243 artially colocalized with CGRP in some large dense-core vesicles (LDCVs).

244 ture of small clear vesicles (CLV) and large dense core vesicles (LDV).

245 unoreactivity in neurons, primarily in large dense-core vesicles located in the cytoplasm.

246 ory organelles (synaptic-like microvesicles, dense-core vesicles, lysosomes, exosomes and ectosomes),

247 detected in large numbers of neurosecretory dense-cored vesicles, many of which are located close to

248 Yet, large dense-core vesicles marked by secretogranin attach to pl

249 sults, this raises the possibility that some dense core vesicles may, like small synaptic vesicles, u

250 This finding suggests that dense-core vesicles may play a role in targeting the DOR

251 ed family member) and determined its role in dense-core vesicle-mediated peptide secretion and in syn

252 nal is transmitted through calcium-activated dense core vesicle neurosecretion.

253 eta cells, IA-2 is an important regulator of dense core vesicle number and glucose-induced and basal

254 e of CART peptide 55-102 immunoreactivity in dense core vesicles of axon terminals suggests that the

255 e receptor proteins spanning the membrane of dense core vesicles of neuroendocrine tissues.

256 dorsal horn are localized exclusively within dense core vesicles of synaptic terminals.

257 is relatively enriched in the purified large dense-core vesicles of chromaffin cells and associated w

258 e, substance P, are colocalized in the large dense-core vesicles of pain-sensing neurons.

259 hormones are stored in the amyloid state in dense-core vesicles of secretory cells.

260 ve peptides are packaged as proproteins into dense core vesicles or secretory granules, where they ar

261 acquisition and the size of the synaptic and dense-core vesicle pool.

262 ter events than quanta associated with large dense-core vesicles previously recorded in vertebrate pr

263 nly in presynaptic cells and may account for dense-cored vesicles previously seen in some taste cells

264 C. elegans mutants lacking the dense-core vesicle priming protein UNC-31 (CAPS) share h

265 nc13-2 and Syt7 form a stimulatory triad for dense-core vesicle priming.

266 Importantly, dense core vesicle release and secretion of the neurotra

267 We conclude that dCAPS is required for dense-core vesicle release and that a dCAPS-dependent me

268 en the ways that synaptic vesicles and large dense-core vesicles release their contents have been emp

269 d SSLV fusion events without affecting large dense core vesicle secretion.

270 , hormones and neuropeptides stored in large dense core vesicles (secretory granules) are released th

271 SgII-containing dense core vesicles share morphological and physical pro

272 th full exocytotic fusion of small clear and dense core vesicles shown in previous morphometric studi

273 changes were correlated with alterations in dense-core vesicle size.

274 signal peptide-containing domain, for large dense core vesicle sorting and regulated secretion from

275 he formation and/or maintenance of the small dense core vesicle subpool in PC12 cells.

276 w that the presence and release of the small dense core vesicle subpool is dependent on synaptotagmin

277 of dense core vesicles, a small and a large dense core vesicle subpool.

278 l size was much less than expected for large dense core vesicles, suggesting that release originated

279 at neuronal exocytosis of neuropeptides from dense core vesicles suppressed the survival of Caenorhab

280 ficial peptide neurotransmitter containing a dense core vesicle targeting domain, a NMDA NR1 subunit

281 Neither large dense core vesicle terminals nor type I synaptic glomeru

282 acts had at least one morphologically docked dense core vesicle that presumably contained peptide; th

283 w that these isoforms sort to populations of dense-core vesicles that differ in size.

284 a decrease in immunolabeling associated with dense-core vesicles that were near the plasma membrane a

285 ted peptide and enkephalins, are packaged in dense-core vesicles, then the LOC terminals synapsing wi

286 ld shift the expression of hVMAT2 from large dense core vesicles to synaptic vesicles.

287 mbrane-tethered PCs were rerouted from large dense core vesicles to the Golgi region.

288 ion and participates in the docking of large dense-core vesicles to the plasma membrane.

289 The FERM domain of PTPN21 stimulates dense core vesicle transport in primary hippocampal neur

290 y the local changes of 27 proteins at single dense-core vesicles undergoing calcium-triggered fusion.

291 tained pleomorphic vesicles as well as large dense core vesicles, varied in size and formed heterogen

292 ted emission depletion microscopy imaging of dense-core vesicles, we find that fusion-generated Omega

293 ntate gyrus, although some dynorphin-labeled dense core vesicles were also observed in dendritic shaf

294 The dense core vesicles were consistently the most immunorea

295 tion; (2) large immunonegative profiles with dense-core vesicles were abundant and were frequently pr

296 CRF-immunoreactive axon terminals containing dense-core vesicles were found in both the caudal dorsol

297 When the dense-core vesicles were near the plasma membrane, somet

298 s, NT-LI was commonly associated with large, dense-cored vesicles, whereas D2-LI was found along the

299 S-1 is required for Ca2+-triggered fusion of dense-core vesicles with the plasma membrane, but its si

300 l accumulation of radiolabeled NE into large dense core vesicles within intact PC12 cells.