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1 ace area only 37% of the high pH form with a dense core.
2 perimetral membrane surrounding an electron-dense core.
3 cell extension distinguished by an electron-dense core.
4 f a relatively hard shell and a softer, less dense core.
5 sma cell possesses a characteristic electron-dense core.
6 e, with enlargement in the volume around the dense core, a phenomenon that occurs to maintain constan
7 izes possible by accreting material around a dense core about one-third to one-half the present size
9 terminal organelle having a central electron-dense core and adhesin-related proteins clustered at a t
10 in that most capsids in the nuclei lacked a dense core and most enveloped particles in the cytoplasm
13 nerve terminals making up each site possess dense-core and/or electron-lucent vesicles, suggesting d
14 ately 7 nm external diameter and an electron dense core, and to form channels of 50picoSiemens conduc
15 f the SP-NC junction, production of electron-dense cores, and cDNA synthesis but blocked retrotranspo
16 -like conformational changes of its electron-dense core are leveraged against a cytoplasmic anchor an
19 e physicochemical properties of the electron-dense core atrial gland vesicles from Aplysia californic
20 lts suggest that nanoparticles interrupt the dense-core biopolymer intragranular matrix and present t
22 e their soluble content aggregates to form a dense core, but the mechanisms controlling biogenesis ar
23 ermination of the dimensions of the electron-dense core by transmission electron microscopy (TEM), wi
25 nhibitor-treated cells lacked DNA-containing dense-core capsids in the nucleus, and only incomplete v
26 l cycle, transitioning between an infectious dense-cored cell (DC) and a noninfectious reticulate cel
27 le, transitioning between a smaller electron dense-cored cell (DC), which has a dense nucleoid, and a
28 VLPT was localized on both reticulate and dense-core cells, and it was found extracellularly in th
30 e gp19 protein was present on reticulate and dense-cored cells, and it was found extracellularly in t
31 : the regulation of catecholamine-containing dense-core chromaffin granule biogenesis in the adrenal
32 focal microscopy demonstrated p47-expressing dense-cored (DC) ehrlichiae colocalized with PCGF5, FYN,
37 ferentially expressed only on the surface of dense-cored ehrlichiae and detected in the Ehrlichia-fre
42 lcineurin b1 (Cnb1) in mouse islets impaired dense core granule biogenesis, decreased insulin secreti
44 expression of factors essential for insulin dense core granule formation and secretion and neonatal
47 differentiation revealed that an increase in dense-core granule catecholamine content by exogenous ap
50 ophila, the polypeptides stored in secretory dense core granules (DCGs) are generated by proteolytic
52 ely in Paneth cells where they occur only in dense core granules and thus are secreted to function in
54 apin co-localized with endogenous torsinA on dense core granules in PC12 cells and was recruited to p
55 t the trafficking of neuropeptide-containing dense core granules is markedly cell type specific and i
56 a secretory epithelial lineage that release dense core granules rich in host defense peptides and pr
57 f molecules from synaptic vesicles and large dense core granules through the process of exocytosis.
58 ss a variety of beta-cell markers, including dense core granules visible by electron microscopy (EM).
60 ere no differences in secretion of [3H]-5HT (dense core granules), platelet factor IV (alpha granules
62 n microscopy revealed cytoplasmic, endocrine-dense core granules, analogous to those found in human n
63 mines and peptides are both contained within dense core granules, whether they are copackaged is less
67 is an important factor for the formation of dense-core granules by regulating the ability of CgA to
68 that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are
69 trahymena thermophila, peptides secreted via dense-core granules, called mucocysts, are generated by
72 ction with chemical models, we find that the dense core has been chemically processed for at least on
73 ck, but both results imply that star-forming dense cores have ages of about one million years, rather
74 plasmic and nuclear structures composed of a dense core inaccessible to nascent polypeptides surround
75 in, a second protein near the taper, forms a dense-core-like structure that is disrupted in the absen
76 TRP120 in HeLa cells and with E. chaffeensis dense-cored morulae and areas adjacent to morulae in the
78 membrane-bound cell extension is an electron-dense core of two segmented rods oriented longitudinally
80 e star-forming regions are comparable to the dense cores of giant molecular clouds in the local Unive
81 n the Milky Way, high-mass stars form in the dense cores of interstellar molecular clouds, where gas
82 ctable on the surfaces of A. phagocytophilum dense core organisms bound at the HL-60 cell surface, bu
85 cations for secretory cargo condensation (or dense core "packing" structure) within the regulated pat
86 his technique is able to distinguish between dense-core particles, liquid-filled, bilayer-coated vesi
88 ity (1.5 nM) for Abeta40 fibrils and labeled dense core plaques better than 6E10 as determined by imm
89 We observed fluorescence associated with dense core plaques, but not diffuse plaques, as determin
90 he non-immunized patients, neurites close to dense-core plaques (within 50 microm) were more abnormal
92 neurites close to and far from the remaining dense-core plaques did not differ, and both were straigh
102 In some cells, the polypeptides stored in dense core secretory granules condense as ordered arrays
103 hat proinflammatory mediators in Paneth cell dense core secretory granules mediate tumor necrosis fac
104 granules, and the agonist-induced fusion of dense core secretory granules to the mast cell plasma me
105 nes and neuropeptides, through the fusion of dense core secretory granules with the cell surface.
106 ic pathway function, biogenesis of mast cell dense core secretory granules, and the agonist-induced f
108 n of the protein architecture of the 'human' dense core secretory vesicles (DCSV) to understand mecha
109 protein tyrosine phosphate family located in dense core secretory vesicles and a major autoantigen in
112 family of prohormones widely distributed in dense-core secretory granules (DCGs) of endocrine, neuro
114 layed very minor overlaps with lysosomes and dense-core secretory granules and were similar to lysoso
115 peptides, which are stored and released from dense-core secretory granules of neuroendocrine cells, h
116 rotid secretory proteins are stored in large dense-core secretory granules that undergo stimulated se
117 localizes to synaptic vesicles and to large dense-core secretory vesicles as reported previously, wh
118 ates, is stored in, and secreted from, large dense-core secretory vesicles in nerve terminals in the
119 Bioactive peptides are packaged in large dense-core secretory vesicles, which mediate regulated s
121 network; the only known role of clathrin in dense-cored secretory granules formation is to remove mi
123 in the final stages of star formation, where dense cores (size approximately 0.1 parsecs) inside mole
126 ll is defined by the presence of an electron-dense core that appears as paired, parallel bars oriente
127 ions of the brain, which collectively form a dense core that enhances the functional integration of a
128 sufficient to create a mass distribution of dense cores that resembles, and sets, the stellar initia
129 ns regarding the composition of the electron-dense core, the means by which the terminal organelle is
130 (+) activated microglia in randomly selected dense-core (Thioflavin-S(+)) plaques from the temporal n
131 PC12 cells are used to test whether altering dense core vesicle (DCV) motion affects neuropeptide rel
133 for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle dock
139 have been analyzed for biological effects on dense core vesicle exocytosis in neuroendocrine PC12 cel
140 fferent systems as follows: Ca(2+)-triggered dense core vesicle exocytosis, spontaneous synaptic vesi
141 sible roles of the CAPS protein in mediating dense core vesicle fusion and modulating synaptic vesicl
143 eta cells, IA-2 is an important regulator of dense core vesicle number and glucose-induced and basal
146 signal peptide-containing domain, for large dense core vesicle sorting and regulated secretion from
148 w that the presence and release of the small dense core vesicle subpool is dependent on synaptotagmin
150 ficial peptide neurotransmitter containing a dense core vesicle targeting domain, a NMDA NR1 subunit
152 o suggested to play a role in Ca2+-dependent dense-core vesicle (DCV) exocytosis in neuroendocrine ce
154 unknown whether the molecular steps of large dense-core vesicle (LDCV) docking and priming are identi
157 UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, resp
158 st that CeIA-2 may be an important factor in dense-core vesicle cargo release with parallels to insul
161 n were defective for anterograde movement of dense-core vesicle components, including egl-3 PC2, egl-
162 oposed to be an important regulator of large dense-core vesicle exocytosis from neuroendocrine tissue
163 " Rab3 and Rab27, regulate late steps during dense-core vesicle exocytosis in neuroendocrine cells.
166 esynaptic UNC-31 activity, likely acting via dense-core vesicle exocytosis, is required to locally ac
172 rface with three other proteins required for dense-core vesicle exocytosis: phospholipase D1 (PLD1),
175 on was enhanced in cell-attached patches and dense-core vesicle fusion pores had conductances that we
178 ed family member) and determined its role in dense-core vesicle-mediated peptide secretion and in syn
180 d a lower frequency of synapse formation and dense-cored vesicle content than CHT-labeled profiles in
181 the receptor is concentrated on peptidergic dense core vesicles (DCVs) and is notably absent from th
182 pported bilayers and purified neuroendocrine dense core vesicles (DCVs) as fusion partners, and we ex
183 ion requires anterograde axonal transport of dense core vesicles (DCVs) containing neuropeptides and
187 nctional relationships of axonal kinesins to dense core vesicles (DCVs) that were filled with a GFP-t
189 beta cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in respon
190 another form of neuronal signaling, that of dense core vesicles (DCVs), whose contents can include n
194 isms responsible for production of the large dense core vesicles (LDCVs) capable of regulated release
195 e role for PICK1 in the biogenesis of large, dense core vesicles (LDCVs) in mouse chromaffin cells.
196 of proteins and neurotransmitters from large dense core vesicles (LDCVs) is a highly regulated proces
199 , hormones and neuropeptides stored in large dense core vesicles (secretory granules) are released th
200 nce that CKA facilitates axonal transport of dense core vesicles and autophagosomes in a PP2A-depende
201 ontacts; 2) small, round vesicles plus a few dense core vesicles and forming asymmetric contacts; or
203 es, endomorphin-2 was contained primarily in dense core vesicles and MOR1 was located primarily at no
204 syt I and VII partially colocalize on large dense core vesicles and that upregulation of syt VII pro
205 eptide precursor VGF that is stored in large dense core vesicles and undergoes regulated secretion.
207 5-HT secreted by both synaptic vesicles and dense core vesicles diffuse readily to the extrasynaptic
208 In Caenorhabditis elegans motor neurons, dense core vesicles dock at the plasma membrane but are
210 h BDNF or its pro-peptide both stained large dense core vesicles in excitatory presynaptic terminals
211 in nerve terminals or the movement of large dense core vesicles in growth cones and endocrine cells.
212 extracellularly applied HRP (0.1%) perturbs dense core vesicles in the synaptic processes of leech n
216 th full exocytotic fusion of small clear and dense core vesicles shown in previous morphometric studi
217 at neuronal exocytosis of neuropeptides from dense core vesicles suppressed the survival of Caenorhab
218 at both calcium-regulated exocytic vesicles (dense core vesicles) and endocytic structures (clathrin-
219 ude small clear vesicles and two subpools of dense core vesicles, a small and a large dense core vesi
220 trinsic neurons, afferent neurons containing dense core vesicles, and systems of serial synaptic comp
222 l size was much less than expected for large dense core vesicles, suggesting that release originated
228 ned by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out
230 imaging of Drosophila and hippocampal neuron dense-core vesicles (DCVs) containing a neuropeptide or
231 ants revealed a 50% reduction in presynaptic dense-core vesicles (DCVs) corresponding to enhanced neu
232 ized distribution of neuropeptide-containing dense-core vesicles (DCVs) in Caenorhabditis elegans cho
235 n essential for the Ca2+-dependent fusion of dense-core vesicles (DCVs) with the plasma membrane and
240 eins depends on their inclusion within large dense-core vesicles (LDCVs) capable of regulated exocyto
241 the function of syb in the docking of large dense-core vesicles (LDCVs) in live PC12 cells using tot
242 presence of estrogen receptor-alpha on large dense-core vesicles (LDCVs) in the hippocampus suggests
243 bly, we found that TRPV1 is present in large dense-core vesicles (LDCVs) that were mobilized to the n
244 cells, VMAT2 localizes exclusively to large dense-core vesicles (LDCVs), and we now show that cytopl
245 quired for release at the synapse, and large dense-core vesicles (LDCVs), which mediate extrasynaptic
249 three ultrastructural types, with clear- or dense-core vesicles and those with a dark cytoplasm havi
256 packing of peptide hormones/neuropeptides in dense-core vesicles do not necessarily require a special
257 ATP release and the number of ATP-containing dense-core vesicles docking are decreased in HD astrocyt
259 y that regulates the exocytic fusion pore of dense-core vesicles in cultured endocrine beta cells.
264 strocytes, suggesting that the exocytosis of dense-core vesicles is impaired by mHtt in HD astrocytes
266 is relatively enriched in the purified large dense-core vesicles of chromaffin cells and associated w
270 a decrease in immunolabeling associated with dense-core vesicles that were near the plasma membrane a
272 y the local changes of 27 proteins at single dense-core vesicles undergoing calcium-triggered fusion.
274 S-1 is required for Ca2+-triggered fusion of dense-core vesicles with the plasma membrane, but its si
275 on-lucent vesicles and, occasionally, large, dense-core vesicles) and symmetrical (with small, flatte
276 ar, spherical vesicles and a few granular or dense-core vesicles, and (4) specialization in the last
277 in neurons, are associated with synaptic and dense-core vesicles, and control vesicle acidification a
278 ect in which a portion of synaptic vesicles, dense-core vesicles, and presynaptic cytomatrix proteins
279 3a, a small GTPase localized on membranes of dense-core vesicles, and prevents GTP-Rab3a from binding
280 re integral membrane components of the large dense-core vesicles, and that they are closely regulated
282 addition to being a resident on cytoplasmic dense-core vesicles, CAPS was present in clusters of app
283 ory organelles (synaptic-like microvesicles, dense-core vesicles, lysosomes, exosomes and ectosomes),
284 ted emission depletion microscopy imaging of dense-core vesicles, we find that fusion-generated Omega
296 ry afferent synapses (C-type), synapses with dense-cored vesicles (D, mostly primary afferents), and
297 nly in presynaptic cells and may account for dense-cored vesicles previously seen in some taste cells
300 on; in the clade of filamentous ascomycetes, dense-core Woronin bodies bud from peroxisomes to gate c
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