ライフサイエンスコーパス: dental pulp

1 r population and not multipotent MSCs in the dental pulp.

2 sitive nociceptors in trigeminal ganglia and dental pulp.

3 ve nociceptors in the trigeminal ganglia and dental pulp.

4 involved in inflammatory hyperalgesia in the dental pulp.

5 erentiation, thus maintaining homeostasis in dental pulp.

6 rom peptidergic afferents innervating bovine dental pulp.

7 e neurons via in vitro superfusion of bovine dental pulp.

8 g trigeminal nerve fibers that innervate the dental pulp.

9 expression by cells derived from the porcine dental pulp.

10 erative population of cells from adult human dental pulp.

11 4 [IL-4], and IL-10) were detected in human dental pulp.

12 rvival function for Msx1 in odontoblasts and dental pulp.

13 ut not by odontoblasts or other cells in the dental pulp.

14 both metabolic and transductive processes in dental pulp.

15 s found in many orofacial tissues, including dental pulp.

16 ATP-permeable channels, are present in human dental pulp.

17 ohydrolases (NTPDases), are present in human dental pulp.

18 f selective cytokines in the regeneration of dental pulp.

19 2) on the revascularization of severed human dental pulps.

20 the hypothesis that EAA receptors in bovine dental pulp activate a population of peptidergic sensory

21 produced by PDL (periodontal ligament), DPA (dental pulp adult), and GF (gingival fibroblast) cells.

22 Nerve fibers of human dental pulp also contained detectable mu-opioid receptor

23 of versican and link protein coincide in the dental pulp and are enriched in the peripheral area of t

24 sor population isolated from postnatal human dental pulp and have the ability to regenerate a reparat

25 resorption occurs following infection of the dental pulp and is mediated mainly by IL-1alpha in the m

26 on of the local complement system within the dental pulp and its role in initiating the regeneration

27 nated and unmyelinated nerve fibers in human dental pulp and may play a role in dental pain mechanism

28 red for ATP release and degradation in human dental pulp and that pannexin channels are involved in e

29 heir innate immunomodulatory activity in the dental pulp and their capability for pulp repair.

30 munohistochemical staining of infected human dental pulp and tissue from experimental dental pulpitis

31 enhanced neovascularization of severed human dental pulps and suggest that topical application of an

32 immune cells in irreversibly inflamed human dental pulp, and extracts of this tissue have significan

33 and distribution of P2X3 receptors in human dental pulp, and their co-localization with other neural

34 y of capsaicin-sensitive neurons innervating dental pulp, and these factors may be significant clinic

35 Inflammatory changes in the dental pulp are accompanied by release of a wide variety

36 Furthermore, Twist-1 functions in dental pulp are dependent on its interaction with Runx2.

37 uilibrium of odontoblast progenitor cells in dental pulp are unknown.

38 nt mesenchymal tissues, the periodontium and dental pulp, are maintained by distinct pools of stem ce

39 that cells in the mesenchymal compartment of dental pulp attenuate osteoclastogenesis.

40 (TNF-alpha) could be a mediator involved in dental pulp cell differentiation toward an odontoblastic

41 l mesenchymal/papilla cells (FDPCs) or human dental pulp cells (ADPCs) under 2-dimensional or 3-dimen

42 Dental pulp cells (DPC) produce an array of neurotrophic

43 imensional (3D) tissues were engineered from dental pulp cells (DPCs) and assessed as a device for pu

44 e-aspartic acid (RGD) peptides, will bind to dental pulp cells (DPCs) and modulate their differentiat

45 ential for osseointegration engineering with dental pulp cells (DPCs) by testing a hypothesis that DP

46 odontogenic/osteogenic differentiation from dental pulp cells (DPCs) in vitro.

47 Human dental pulp cells (DPCs), adherent cells derived from de

48 ts of light-emitting diode (LED) exposure on dental pulp cells (DPCs).

49 l line-derived neurotrophic factor (GDNF) on dental pulp cells (DPCs).

50 n vitro, Wnt5a was increased 8-fold in human dental pulp cells (HDPCs) after TNF-alpha stimulation co

51 ans ATCC90028, the cytotoxicity toward human dental pulp cells (HDPCs), and the mechanical properties

52 nt cells from donor-matched rat dental pulp (dental pulp cells [DPCs]) and alveolar bone (alveolar bo

53 rscoring the need for therapies that protect dental pulp cells and enhance their regeneration.

54 Dental pulp cells and mouse odontoblast-like cells (MDPC

55 nx2, Gli1, Numb, and Notch expression in the dental pulp cells and odontoblasts of DSPP-null mice whe

56 ficantly ameliorated its cytotoxicity to the dental pulp cells and restored their odontoblast-like ce

57 system to study the interactions between the dental pulp cells and trigeminal neurons.

58 However, it is not clear whether dental pulp cells can be recruited endogenously for rege

59 Dental pulp cells can differentiate toward an odontoblas

60 ginate hydrogel with pulp ECM components and dental pulp cells followed by differentiation induction

61 agen hydrogels were seeded either with human dental pulp cells from patients with characterized PHEX

62 Insights into the role of mesenchymal dental pulp cells in attenuating dentin resorption in ho

63 We show that dental pulp cells produce several neurotrophic factors i

64 However, the mechanisms by which dental pulp cells recognize lipopolysaccharides (LPSs) r

65 Long-term G5-RGD treatment of dental pulp cells resulted in enhanced mineralization as

66 Furthermore, adult dental pulp cells supplemented with these two growth fac

67 tudy was that LTA induces VEGF expression in dental pulp cells through TLR2 and PI3k/Akt signaling.

68 amined the effects of continuous exposure of dental pulp cells to FGF2 and showed that the effects of

69 that TNF-alpha stimulates differentiation of dental pulp cells toward an odontoblastic phenotype via

70 Human immortalized dental pulp cells were driven toward an odontoblast phen

71 Primary dental pulp cells were subsequently seeded onto pulp-der

72 Ten percent of the rat dental pulp cells were viable when cultured on the PMMA

73 fferentiation could be achieved by culturing dental pulp cells with their associated ECM.

74 ormed using human skeletal (MG63 and primary dental pulp cells) and salivary gland (HSG) cells.

75 with porcine dental epithelial cells, human dental pulp cells, and human umbilical vein endothelial

76 Thus, endogenous dental pulp cells, including stem/progenitor cells, may

77 Using multiple models, such as dental pulp cells, induced pluripotent stem cell (iPSC)-

78 vascular endothelial growth factor (VEGF) in dental pulp cells.

79 embryonic cells and populations of postnatal dental pulp cells; however, these cells are unable to co

80 Moreover, human dental pulp collected from patients with caries lesions

81 tus for ATP release and degradation in human dental pulp, consistent with the involvement of ATP sign

82 strategy for engineering of pre-vascularized dental pulp constructs offering potentially beneficial t

83 Also tested was the hypothesis that dental pulp contains either the B1 or B2 or both BK rece

84 Since the dental pulp contains hyaluronan, versican may bind to hy

85 ed and adherent cells from donor-matched rat dental pulp (dental pulp cells [DPCs]) and alveolar bone

86 domain peptide (MDP) hydrogel scaffolds with dental pulp-derived cells but were limited in their abil

87 indings suggest that LNGFR(Low+)THY-1(High+) dental pulp-derived cells provide an excellent source of

88 Prospectively isolated, dental pulp-derived LNGFR(Low+)THY-1(High+) cells repres

89 , indicating a functional bioactivity of the dental pulp-derived neurotrophic factors in vivo by resc

90 Based on these findings, we propose that dental pulp-derived neurotrophic factors play an importa

91 arborizations of neurons that innervate the dental pulp (DP) and periodontal tissues (PDL).

92 ls (BMSC) with stem cells derived from human dental pulp (DPSC), apical papilla (SCAP) and follicle (

93 During caries, dental pulp expresses a range of pro-inflammatory cytoki

94 e scaffold that mimics the complexity of the dental pulp extracellular matrix (ECM).

95 cretion is evoked from isolated terminals of dental pulp fibers via the bradykinin B2 receptor-depend

96 n in dental pulp stem cells (DPSC) and human dental pulp fibroblasts (HDPF) through mitogen-activated

97 e C5a receptor (C5aR), here we show that all dental pulp fibroblasts, localized beneath the carious i

98 n an elemental neurosensory structure, human dental pulp, following chronic carious insult.

99 astrophic failure, while also protecting the dental pulp from bacterial attack.

100 Thus, this study reports that human dental pulp from healthy extracted teeth can be successf

101 Dental pulps from erupted incisors displayed increased p

102 Dental pulp has intrinsic capacity for self-repair.

103 a multifunctional role in the regulation of dental pulp homeostasis.

104 Finally, Wnt5a participates in dental pulp inflammation in a MAPK-dependent (p38-, JNK-

105 ent and as an inflammatory mediator in human dental pulp inflammation.

106 Studies of the developing dental pulp innervation by nerve fibers from the trigemi

107 play an important role in orchestrating the dental pulp innervation.

108 Preservation of a vital dental pulp is a central goal of restorative dentistry.

109 Because the dental pulp is frequently infected by oral bacteria due

110 Here we tested whether homeostasis in dental pulp is modulated by Twist-1, a nuclear protein t

111 Infection of the dental pulp leads to an osteolytic lesion that results f

112 heroids can successfully regenerate vascular dental pulp-like tissue and also highlight the significa

113 en fabricated pre-vascularized, full-length, dental pulp-like tissue constructs by dispensing OD21 ce

114 PC engineered tissues can regenerate a vital dental pulp-like tissue in a tooth root canal system and

115 activation of AMPA and kainate receptors in dental pulp may contribute to peripheral release of vaso

116 Up-regulation of VEGF expression in the dental pulp may result in increased intra-pulpal pressur

117 aled that this DSP domain induces endogenous dental pulp mesenchymal cell proliferation, differentiat

118 s is typically accompanied by an increase in dental pulp microvascular density.

119 the odontoblast layer, subodontoblast layer, dental pulp nerve bundles, and blood vessels.

120 cific questions regarding development of the dental pulp nerve system to be addressed.

121 nhanced TRPA1 expression was also evident in dental pulp of carious compared with noncarious teeth.

122 mixed anaerobic infection, we inoculated the dental pulp of mice with six anaerobic pathogens contain

123 The inflammation observed in the dental pulp of teeth with deep caries lesions is charact

124 hronic interstitial polymicrobial infection, dental pulps of MCP-1(-/-) mice and controls were inocul

125 The dental pulps of the first molars were exposed and infect

126 ain insight into the potential population in dental pulps of unerupted and erupted incisors that give

127 ntation with mesenchymal stem cells from the dental pulp on poly-l-lactic acid scaffolds in nude mice

128 for immediate vascularization of engineered dental pulp poses a major hurdle towards successful impl

129 ontoblast-like cell differentiation of human dental pulp progenitor cells (DPSCs).

130 ue constructs in full-length root canals for dental pulp regeneration.

131 re major hurdles that need to be overcome in dental pulp regeneration.

132 carious teeth and plays an important role in dental-pulp regeneration via interaction of the active C

133 emperature and pH of isolated superfused rat dental pulp regulate capsaicin-induced release of calcit

134 Bacterial infections of the dental pulp result in soft tissue and alveolar bone dest

135 Bacterial infections of the dental pulp result in tissue destruction and periapical

136 that activation of beta(2)-adrenoceptors in dental pulp significantly reduces exocytosis of neuropep

137 re increased and deposited abnormally in the dental pulp, similar to the hereditary human tooth disor

138 om MEPE (Dentonin or AC-100) could stimulate dental pulp stem cell (DPSC) proliferation and/or differ

139 e adhesion behavior of a population of human dental pulp stem cell (hDPSC) on 64 combinations of nano

140 dothelial growth factor (VEGF) expression in dental pulp stem cells (DPSC) and human dental pulp fibr

141 Dental pulp stem cells (DPSC) are a relatively new alter

142 Dental pulp stem cells (DPSCs) are a unique precursor po

143 Human dental pulp stem cells (DPSCs) can be isolated from infl

144 Dental pulp stem cells (DPSCs) have previously demonstra

145 oblastic MC3T3-E1 cells and preodontoblastic dental pulp stem cells (DPSCs) in a dose-dependent manne

146 tial for autologous transplantation of human dental pulp stem cells (DPSCs) in endodontic treatment.

147 differentiation and mineralization of human dental pulp stem cells (DPSCs) in two-dimensional cell c

148 Dental pulp stem cells (DPSCs) possess immunoregulatory

149 se of scaffold-free microtissue spheroids of dental pulp stem cells (DPSCs) prevascularized by human

150 Post-natal human dental pulp stem cells (DPSCs) represent a unique precur

151 cells have been isolated and characterized: dental pulp stem cells (DPSCs), stem cells from exfoliat

152 terials that can support native functions of dental pulp stem cells (DPSCs), which are capable of reg

153 bone marrow stromal stem cells (BMSSCs) and dental pulp stem cells (DPSCs).

154 capacity, and clonogenic efficiency of human dental pulp stem cells (DPSCs).

155 sive regulatory functions of disease-derived dental pulp stem cells (DPSCs).

156 ogenic differentiation and mineralization of dental pulp stem cells (DPSCs).

157 G1 RSs were injected with human dental pulp stem cells (hDPSCs) and human umbilical vein

158 on the viability and proliferation of human dental pulp stem cells (hDPSCs) by comparing the cellula

159 Cytotoxicity was examined on human dental pulp stem cells (hDPSCs).

160 The discovery that dental pulp stem cells are capable of differentiating in

161 characteristics of the previously identified dental pulp stem cells can generate mineralized tissue o

162 also observed in T4-4 preodontoblast cells, dental pulp stem cells, and primary preodontoblasts.

163 5% NaOCl and triple antibiotic paste, ferret dental pulp stem cells, encapsulated in a hydrogel scaff

164 signaling in endothelial differentiation of dental pulp stem cells.

165 iently induce endothelial differentiation of dental pulp stem cells.

166 differentiation and mineralization of human dental pulp stem cells.

167 dhesives eluates were cytotoxic to the human dental pulp stem cells.

168 ulator of the endothelial differentiation of dental pulp stem cells.

169 Human dental pulp stem/progenitor cells (hDPSCs) are attractiv

170 This work is based on a hypothesis that dental pulp stem/progenitor cells can be induced to migr

171 her late function of Msx1 in odontoblast and dental pulp survival.

172 useful indication of tissue distress in the dental pulp that could be used to investigate the early

173 populations in the rodent incisor apex, the dental pulp, the alveolar bone, the periodontal ligament

174 adult stem cells have been isolated from the dental pulp, the deciduous tooth, and the periodontium.

175 In the unique microenvironment of the dental pulp, the triad of tissue engineering would requi

176 ered centrally and peripherally within whole dental pulp tissue are shown to be biocompatible, preser

177 In addition, we show that dental pulp tissue becomes innervated when transplanted

178 Interestingly, grafting the dental pulp tissue into hemisected spinal cord increases

179 veloping dental mesenchyme and whether adult dental pulp tissue maintains its inductive capability re

180 Here, we identified a dental pulp tissue-specific cell population based on the

181 blished the inductive potential of postnatal dental pulp tissue.

182 lp cells (DPCs), adherent cells derived from dental pulp tissues, are potential tools for cell transp

183 ascularization treatment to regenerate human dental pulp tissues.

184 ated 3 methods of decellularization of human dental pulp to be used as a potential autograft scaffold

185 e present study used isolated superfused rat dental pulp to test the hypothesis that capsaicin recept

186 We therefore investigated human dental pulps to determine if angiogenic changes could be

187 emistry, we detected ecto-AMPase activity in dental pulp, trigeminal ganglia (TG) neurons, and their

188 We further tested if ATP is released from dental pulp upon dentin mechanical or thermal stimulatio

189 rity and extracellular matrix composition of dental pulp varies considerably during tooth development

190 ction, we used an in vivo model in which the dental pulp was inoculated with six anaerobic pathogens,

191 Bovine dental pulp was prepared and stimulated by the superfusi

192 In vitro superfusion of bovine dental pulp was used to evaluate the regulation of iCGRP

193 trigeminal ganglia and by 26% (p < 0.05) in dental pulp when tissues were pre-treated with [Leu(31),

194 ude that BK evokes iCGRP release from bovine dental pulp which is enhanced by a positive interaction

195 present a unique precursor population in the dental pulp, which has multipotential and can regenerate

196 Subsequent infection of the dental pulp with P. gingivalis caused extensive inflamma

197 s study, the effect of mono-infection of the dental pulp with T. denticola and with polymicrobial "re

198 enchymal stromal cells, extracted from human dental pulp, with no adverse effects on cell viability,