ライフサイエンスコーパス: dentate granule cell

1 ed NR2A and NR2B hybridization densities per dentate granule cell.

2 r KCNQ2 but was reduced approximately 50% in dentate granule cells.

3 ural evidence for axoaxonic gap junctions in dentate granule cells.

4 ce despite normal dendritic spine density on dentate granule cells.

5 ssion, indicating a special vulnerability of dentate granule cells.

6 ribute to the low-pass filtering function of dentate granule cells.

7 ing increase in hypersynchronous activity of dentate granule cells.

8 were unchanged following COX10 removal from dentate granule cells.

9 avioral seizure, Fos labeling was evident in dentate granule cells.

10 ocalize with synaptic markers in hippocampal dentate granule cells.

11 timulation-induced activation of hippocampal dentate granule cells.

12 dal neurons in CA3, and in a small number of dentate granule cells.

13 ition at physiological firing frequencies of dentate granule cells.

14 ptic inputs similar to those found in mature dentate granule cells.

15 outons, but rather to all synapses formed by dentate granule cells.

16 of zinc released at mossy fiber synapses on dentate granule cells.

17 he property of being monosynaptic targets of dentate granule cells.

18 ptic release of both glutamate and GABA onto dentate granule cells.

19 in a majority of cortical regions and in the dentate granule cells.

20 es present on soma and proximal dendrites of dentate granule cells.

21 daily seizures on P10-P25 had an increase in dentate granule cells.

22 imals also demonstrated vulnerability of the dentate granule cells.

23 aralleled by electrophysiological changes in dentate granule cells.

24 om aberrant connections formed by newly born dentate granule cells.

25 s, such as hippocampal pyramidal neurons and dentate granule cells.

26 lective induction of GAD65 and GAD67 mRNA in dentate granule cells.

27 ay be implicated in the hyperexcitability of dentate granule cells.

28 ant path input-output operation in epileptic dentate granule cells.

29 erved that Aplp1 mRNA is highly expressed in dentate granule cells.

30 y afferent pathway from entorhinal cortex to dentate granule cells.

31 rent altering intrinsic firing properties of dentate granule cells.

32 in regulating plasticity of the mPP onto the dentate granule cells.

33 the medial perforant path (mPP) synapse onto dentate granule cells.

34 eletion of alpha-CaMKII from newly generated dentate granule cells.

35 nificantly enhances tonic GABA inhibition in dentate granule cells.

36 icrodialysis, negligible GABA is detected by dentate granule cells.

37 of CA1 pyramidal cells and the dispersion of dentate granule cells.

38 in a significant increase in the density of dentate granule cells.

39 input strength and dendritic spine number in dentate granule cells.

40 assess synaptic function in Ptchd1-deficient dentate granule cells.

41 ere they differentiate into neurons known as dentate granule cells.

42 down Pten in mouse neonatal and young adult dentate granule cells.

43 Hippocampal dentate granule cell abnormalities are thought to play a

44 -epileptic animals, these strongly inhibited dentate granule cells act as a gate, regulating hippocam

45 r (GABAR) currents recorded from hippocampal dentate granule cells acutely dissociated from 28-35-day

46 macological properties of GABAA receptors on dentate granule cells acutely isolated from hippocampi o

47 Here we find that hippocampal dentate granule cells adapt their spiking threshold to t

48 play a central role in the reorganization of dentate granule cells after entorhinal denervation in vi

49 ntaneous inhibitory postsynaptic currents in dentate granule cells after FPI, and ionotropic glutamat

50 Newly generated dentate granule cells also appeared in ectopic locations

51 he strata oriens and radiatum of CA3, in the dentate granule cell and molecular layers, and in the de

52 luding increased levels of alpha4 subunit in dentate granule cells and associated functional alterati

53 ect link between the primary cilia of mature dentate granule cells and behavior will require further

54 principal neurons within the hippocampus-the dentate granule cells and CA1 pyramidal cells.

55 ity on synapse formation between hippocampal dentate granule cells and CA3 pyramidal neurons in cultu

56 ation at medial perforant path synapses onto dentate granule cells and dentate gyrus-dependent cognit

57 Muscarine also depolarizes dentate granule cells and elevates their rate of firing.

58 We examined synaptic inhibition of dentate granule cells and excitability of surviving GABA

59 transmitted by the mossy fiber projection of dentate granule cells and expresses an NMDA receptor-ind

60 n spikes and epileptiform discharges in both dentate granule cells and hippocampal pyramidal neurons,

61 gated altered GABAergic neurotransmission in dentate granule cells and interneurons following chronic

62 oupings (i.e., pyramidal cells as opposed to dentate granule cells and interneurons) were significant

63 ins IFT20 and Kif3A (respectively) in mature dentate granule cells and investigated hippocampus-depen

64 th recurrent seizures had greater numbers of dentate granule cells and more newly formed granule cell

65 an electrophysiology-based classification of dentate granule cells and mossy cells in mice that we va

66 stablish aberrant recurrent synapses between dentate granule cells and operate via postsynaptic kaina

67 portion of those subunits in the interior of dentate granule cells and other hippocampal neurons with

68 NR2A mRNA was higher in dentate granule cells and pyramidal cells in CA1 and sub

69 se data demonstrate that tonic inhibition in dentate granule cells and thalamic relay neurons is medi

70 hese mice show a lack of tonic inhibition in dentate granule cells and thalamic relay neurons.

71 ormation of reciprocal circuitry between the dentate granule cells and the grafted CA3 pyramidal neur

72 specialized contacts between mossy fibers of dentate granule cells and thorny excrescences (TEs) of C

73 al hilar region are known to project both to dentate granule cells and to interneurons, it is as yet

74 nduce LTP both monosynaptically for input to dentate granule cells and transsynaptically for mossy fi

75 ML), where perforant path axons synapse with dentate granule cells, and (2) the stratum lucidum (SL)

76 ionships of the hippocampal pyramidal cells, dentate granule cells, and GABAergic interneurons.

77 , decreases late rectifying K+ current(s) in dentate granule cells, and impairs memory but not other

78 t to CA3 transsynaptically via excitation of dentate granule cells, and that patterns of stimulation

79 ne density was decreased on the dendrites of dentate granule cells, and there was reorganization of i

80 ng both tonic and phasic GABAergic inputs to dentate granule cells, APP maintains excitatory-inhibito

81 These data document for the first time that dentate granule cells are among the cell types most vuln

82 In the adult mammalian hippocampus, newborn dentate granule cells are continuously integrated into t

83 chronically epileptic rats demonstrate that dentate granule cells are maximally hyperexcitable immed

84 ong-standing hypothesis that newly generated dentate granule cells are pro-epileptogenic and contribu

85 e glutamatergic cell types, including mature dentate granule cells, area CA1-3 pyramidal cells and mo

86 lobe origin, has established the hippocampal dentate granule cells as a functional barrier to invasio

87 enervation-induced synaptic scaling of mouse dentate granule cells as a model system.

88 These findings raise doubts about dentate granule cells as a source of spontaneous seizure

89 precipitate changes in tonic conductances in dentate granule cells as measured by whole-cell patch-cl

90 lasticity of retrovirally labeled adult-born dentate granule cells at different stages during their n

91 Dentate granule cell axon (mossy fiber) sprouting is a c

92 We hypothesize that sprouting of dentate granule cell axons (mossy fibers) in response to

93 Reorganization of dentate granule cell axons (mossy fibers) is a prominent

94 After epileptogenic injuries, dentate granule cell axons (mossy fibers) sprout and for

95 Aberrant reorganization of dentate granule cell axons, the mossy fibers, occurs in

96 gest in principal cells of the CA3 field and dentate granule cells but absent in CA1.

97 These neurons resembled dentate granule cells but had axon collaterals in the mo

98 mission at recurrent mossy fiber synapses on dentate granule cells but not at perforant path or assoc

99 ales and males and studied the morphology of dentate granule cells by intracellular dye filling in a

100 e hilar neurons or reduced activation of the dentate granule cells by seizures.

101 derate throughout, with higher expression in dentate granule cells, CA1 and CA3 pyramidal cells than

102 visual cortex, in the hippocampal formation (dentate granule cells, CA2 cells, fasciola cinereum, ind

103 Cell counting of dentate granule cells, CA3, CA1, and hilar neurons, with

104 Dentate granule cells communicate with their postsynapti

105 absence of neurogenesis suggests that mature dentate granule cells contribute substantially to seizur

106 ppocampal adult neurogenesis, and adult-born dentate granule cells contribute to the pathologic retro

107 Single spikes in dentate granule cells, controlled intracellularly, gener

108 Inputs from dentate granule cells converge on the hilus, and excitat

109 The mossy fiber (MF) axons of the dentate granule cells convey strong excitatory drive to

110 These differences in the properties of dentate granule cells correlated positively with age but

111 Dentate granule cell death occurred at 6 h post-TMT as d

112 al afferents (part of the perforant path) to dentate granule cells, dentate mossy fiber inputs to CA3

113 We found the following: (1) Aged female dentate granule cells deprived of gonadal steroids long-

114 ales deprived short-term; however, aged male dentate granule cells deprived of gonadal steroids long-

115 In patients with temporal lobe epilepsy some dentate granule cells develop basal dendrites.

116 Silenced dentate granule cells develop with input-specific decrea

117 evealed that, unlike CA1 neuron populations, dentate granule cell (DGC) ensembles activated by learni

118 The dentate granule cell (DGC) layer is often abnormal in hu

119 Dentate granule cell (DGC) neurogenesis persists through

120 Dentate granule cell (DGC) neurogenesis persists through

121 pocampal cultures, with a major focus on the dentate granule cell (DGC) population, to explore the si

122 the integration and functions of adult-born dentate granule cell (DGCs) are poorly understood.

123 d modulation of GABA(A) receptors present on dentate granule cells (DGCs) acutely isolated from epile

124 tand how monosynaptic inputs onto adult-born dentate granule cells (DGCs) are altered in experimental

125 h CA3 interneurons peak when adult-generated dentate granule cells (DGCs) are approximately 4 weeks o

126 New dentate granule cells (DGCs) are continuously generated,

127 Dentate granule cells (DGCs) are the principal cell popu

128 morphology was studied in human hippocampal dentate granule cells (DGCs) by intracellularly-injectin

129 were recorded from CA1 pyramidal neurons and dentate granule cells (DGCs) by voltage clamp technique.

130 Adult-born dentate granule cells (DGCs) contribute to learning and

131 During limbic epileptogenesis in vivo the dentate granule cells (DGCs) exhibit increased expressio

132 ptic responses were prolonged in hippocampal dentate granule cells (DGCs) from which multiple spikes

133 nit mRNAs simultaneously in individual human dentate granule cells (DGCs) harvested during hippocampe

134 Dentate granule cells (DGCs) have a single, complex, api

135 from retrovirus-labeled newborn hippocampal dentate granule cells (DGCs) in acute mouse brain slices

136 clamp recordings from visualized hippocampal dentate granule cells (DGCs) in slices that were prepare

137 the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they

138 osteroid sensitivity of GABA(A) receptors on dentate granule cells (DGCs) is diminished; the molecula

139 normally integrated, adult-born, hippocampal dentate granule cells (DGCs) is hypothesized to contribu

140 systems-based mechanisms by which adult-born dentate granule cells (DGCs) modulate pattern separation

141 uency of inhibitory postsynaptic currents in dentate granule cells (DGCs) recorded from epileptic ani

142 transformation of GABAergic action occurs in dentate granule cells (DGCs), located at the first stage

143 Local application of FGF22 on the axons of dentate granule cells (DGCs), which are presynaptic to C

144 The continuous addition of new dentate granule cells (DGCs), which is regulated exquisi

145 inhibitory postsynaptic currents (sIPSCs) in dentate granule cells (DGCs).

146 cteristics of the principal cells of the DG, dentate granule cells (DGCs).

147 Unlike arcuate neurons, dentate granule cells did not express the endogenous POM

148 Hippocampal dentate granule cells directly excite and indirectly inh

149 Prolonged dentate granule cell discharges produce hippocampal inju

150 rtex, the feed-forward inhibitory control of dentate granule cell discharges was compromised, and the

151 synaptic GABAA receptor-mediated currents in dentate granule cells display slower rise and decay kine

152 Our results reveal that deletion of Pten in dentate granule cells dysregulates synaptic plasticity,

153 nutrition significantly alters modulation of dentate granule cell excitability (i.e., PPI values usin

154 sure of the type and degree of modulation of dentate granule cell excitability elicited by stimulatio

155 al protein malnutrition on the modulation of dentate granule cell excitability in freely moving rats

156 , reducing inhibitory efficacy and enhancing dentate granule cell excitability.

157 Dentate granule cells exhibit exceptionally low levels o

158 We found that adult-born dentate granule cells exhibit tortuous, yet highly stere

159 These data suggest that hippocampal dentate granule cells expressed GABARs with distinctive

160 For example, hippocampal dentate granule cells expressed Kv3.3 subunits specifica

161 strated that late paired-pulse depression of dentate granule cell field potentials decreases when sti

162 of early and late paired pulse depression of dentate granule cell field potentials were compared in t

163 lation model another neuroplastic change for dentate granule cells following seizures: hilar basal de

164 Dentate granule cells following trauma showed enhanced a

165 In many persons with temporal lobe epilepsy, dentate granule cells form an interconnected synaptic ne

166 mossy fiber en passant boutons of adult-born dentate granule cells form initial synaptic contacts wit

167 ocampal mossy fibers, which are the axons of dentate granule cells, form powerful excitatory synapses

168 Experiments were performed in dentate granule cells from control rats and rats with te

169 Recordings in dentate granule cells from delta subunit-deficient mice

170 In dentate granule cells from juvenile rats polysynaptic fe

171 changes in the pharmacological properties of dentate granule-cell GABAA receptors occurred during the

172 red the functional properties of hippocampal dentate granule cell GABARs.

173 Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acidA (GABAA) re

174 Cs) in the dentate gyrus receive inputs from dentate granule cells (GCs) and project back to GCs loca

175 Newly generated dentate granule cells (GCs) are relevant for input discr

176 for a novel, highly detailed active model of dentate granule cells (GCs) replicating a wide palette o

177 in early, developmentally born, hippocampal dentate granule cells (GCs).

178 tify systematically the relative position of dentate granule cells generated at different ages.

179 2-immunoreactive principal cells, including dentate granule cells, hilar mossy cells, and hippocampa

180 eptogenesis may involve gradually developing dentate granule cell hyperexcitability caused by neuron

181 t differences in the intrinsic properties of dentate granule cells (i.e., input resistance, time cons

182 ogical development and mispositioning of new dentate granule cells in a cell-autonomous fashion.

183 tion of CA3 pyramids with sparing of CA1 and dentate granule cells in all age groups.

184 udies have established a role for adult-born dentate granule cells in discriminating between similar

185 or epilepsy research, and the involvement of dentate granule cells in early seizure events continues

186 al investigators have shown the existence of dentate granule cells in ectopic locations within the hi

187 Here we show that in rat dentate granule cells in ex vivo hippocampal slices, ton

188 inhibitory postsynaptic currents (IPSCs) in dentate granule cells in in vitro slices prepared from b

189 port chain of mitochondria, from hippocampal dentate granule cells in mice does not affect low-freque

190 primary cultures of rat hippocampal neurons, dentate granule cells in mouse organotypic slices, and l

191 res of rat hippocampal and cortical neurons, dentate granule cells in mouse organotypic slices, and l

192 n a moderate decrease in the number of adult dentate granule cells in null mice and an increase in th

193 s, by using time-lapse imaging of denervated dentate granule cells in organotypic entorhino-hippocamp

194 r elicited GABAergic inhibitory responses in dentate granule cells in pilocarpine-treated mice but no

195 mentary electrophysiological recordings from dentate granule cells in SE-treated slices demonstrated

196 ury on the perisomatic inhibitory control of dentate granule cells in the adult rat, with special ref

197 ll proliferation and neuronal development of dentate granule cells in the hippocampus.

198 euronal necrosis in the cortex and injury of dentate granule cells in the hippocampus.

199 mRNA: cerebellar granule cell precursors and dentate granule cells in the hippocampus.

200 ate gyrus, with the most profound effects on dentate granule cells in the innermost portion of the gr

201 hologic and electrophysiologic properties of dentate granule cells in the young adult rhesus monkey (

202 nt conservation of both form and function in dentate granule cells in these two species, despite the

203 ll patch-clamp recordings were obtained from dentate granule cells in transverse hippocampal slices i

204 -lasting GABAergic inhibition of hippocampal dentate granule cells in vivo and in vitro.

205 ssy cells are significantly more active than dentate granule cells in vivo, exhibit spatial tuning du

206 ediated currents are particularly evident in dentate granule cells in which they play a major role in

207 These findings suggest that dentate granule cells in young and adult animals express

208 eling reveal a high degree of abnormality in dentate granule cells, including heterotopic localizatio

209 tide-containing hippocampal interneurons and dentate granule cell inhibition were investigated at dif

210 lso protected the animals from the scattered dentate granule cell injury observed in non-medicated an

211 rves mainly to facilitate the recruitment of dentate granule cells into population bursts.

212 Mossy fiber sprouting by the dentate granule cells is a well-characterized manifestat

213 Axon sprouting in dentate granule cells is an important model of structura

214 control of migration and cell positioning of dentate granule cells is not clear.

215 nstead reflects an abnormality of developing dentate granule cells is unknown.

216 d whole-cell GABAR currents from hippocampal dentate granule cells isolated acutely from control rats

217 mpal neurons in vitro and in vivo Adult-born dentate granule cells lacking Trim9 similarly exhibited

218 increases in BDNF mRNA were detected in the dentate granule cell layer (73.4%), region CA1 (28.1%),

219 0-microm-thick hippocampal neuron-generating dentate granule cell layer (DGCL) consistently within a

220 This leads to malformation of the dentate granule cell layer and excess cell death.

221 hippocampus, FG-positive interneurons of the dentate granule cell layer and hilus were detected in nu

222 Finally, the hippocampal CA2 region and dentate granule cell layer and the caudate-putamen, cons

223 Interneurons located near the border of the dentate granule cell layer and the hilus were studied in

224 els in the hippocampal pyramidal cell layer, dentate granule cell layer and throughout the cortex and

225 The injections of biocytin into the dentate granule cell layer labeled neurons in a Golgi-li

226 comparing field potentials recorded from the dentate granule cell layer of hippocampal brain slices f

227 The dentate granule cell layer of the rodent hippocampal for

228 -associated cells that did not innervate the dentate granule cell layer, and these synapses demonstra

229 ubtle changes in neuronal density within the dentate granule cell layer.

230 subgranular zone along the hilar side of the dentate granule cell layer.

231 responses recorded in the CA1 pyramidal and dentate granule cell layers in response to afferent stim

232 eletion of alpha-CaMKII from newly generated dentate granule cells led to an increase in dendritic co

233 tic responses and dynorphin to disappear via dentate granule cell loss, failed neurogenesis and poor

234 Reduced inhibition of dentate granule cells may contribute.

235 ent GAD and GABA expression in glutamatergic dentate granule cells may have fundamental implications

236 The up-regulation of I(A) in dentate granule cells might have protective effects.

237 hing for candidate ligands that may regulate dentate granule cell migration, we found that SDF1, a ch

238 expressed in patterns that suggest a role in dentate granule cell migration.

239 lant assay showed that it directly regulates dentate granule cell migration.

240 status epilepticus significantly attenuated dentate granule cell neurogenesis after seizures.

241 er status epilepticus, essentially abolished dentate granule cell neurogenesis but failed to prevent

242 stigate the effects of prolonged seizures on dentate granule cell neurogenesis in adult rats, and to

243 These results indicate that dentate granule cell neurogenesis in the mature hippocam

244 that prolonged seizure discharges stimulate dentate granule cell neurogenesis, and that hippocampal

245 , as well as their potential relationship to dentate granule cell neurogenesis, is unknown.

246 hese findings support the hypothesis that in dentate granule cells NMDA receptors are increased, and

247 These results indicate that dentate granule cells normally contain two "fast-acting"

248 Furthermore, new dentate granule cell number, morphology and excitatory s

249 d whether status epilepticus-induced HBDs on dentate granule cells occur in the pilocarpine model of

250 lar neurons and hippocampal pyramidal cells, dentate granule cells of animals are generally regarded

251 ta subunits within GABAergic synapses on the dentate granule cells of CIE rats.

252 Dentate granule cells of p35-deficient mice also demonst

253 amma-aminobutyric acidA receptors present on dentate granule cells of rats with temporal lobe epileps

254 xcitatory axons (the mossy fibers) of normal dentate granule cells of rats, mice, and the monkey Maca

255 week-old pups and in the hilar border of the dentate granule cells of the 3-week-old animals.

256 butyric acid type A receptors (GABA(A)Rs) in dentate granule cells of the hippocampus has been associ

257 required for structural synapse formation in dentate granule cells or for Shh-dependent neuronal prec

258 ed by increased binding of Egr3 to GABRA4 in dentate granule cells, our findings support a role for E

259 luding embryonic piriform cortical cells and dentate granule cell precursors.

260 inate in a discrete band on the dendrites of dentate granule cells, produced a two-stage alteration i

261 ntate stem cells and absolutely required for dentate granule cell production.

262 ain x-irradiation to eliminate proliferating dentate granule cell progenitors in adult rats.

263 ages, there was a reduction in the number of dentate granule cell progenitors in the dentate ventricu

264 However, its role in the function of mature dentate granule cells remains unknown.

265 Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of MF-CA3 LT

266 Electrophysiological recordings from dentate granule cells revealed that high-frequency stimu

267 SnRNA-seq of mouse dentate granule cells reveals large-scale changes in the

268 y the rate of dendritic outgrowth of newborn dentate granule cells, single injections of 5-bromo-2-de

269 d by two different TRPV1 shRNAs expressed in dentate granule cells, strongly supporting a functional

270 ical variables obtained from epileptic human dentate granule cells studied in slices with hippocampal

271 rization current (IsAHP) was also reduced in dentate granule cells, suggesting that KCNQ channels mig

272 ng-term potentiation (LTP) at perforant path-dentate granule cell synapses in ovariectomized female r

273 tions in synaptic plasticity at both CA1 and dentate granule cell synapses, and impaired spatial cogn

274 tiation (LTP) is deficient at perforant path-dentate granule cell synapses.

275 g-term potentiation at medial perforant path-dentate granule cells synapses in FX mice.

276 es have shown that BDNF has acute effects on dentate granule cell synaptic transmission, and other st

277 In dentate granule cells, the calcium binding ratio (kappa)

278 ral lobe epilepsy is recurrent excitation of dentate granule cells through aberrant sprouting of thei

279 roliferative zone that continues to generate dentate granule cells throughout life.

280 These data suggest that the response of rat dentate granule cells to aging and estradiol is sexually

281 he axonal mossy fiber bundle projecting from dentate granule cells to CA3 pyramidal neurons.

282 ntrol of the Thy1.2 promoter, the ability of dentate granule cells to form the SA and to homeostatica

283 -enriched mossy fibers that project from the dentate granule cells to hilar and CA3 pyramidal neurons

284 ct a growing role of the projection from the dentate granule cells to subfield CA3c and from there to

285 ine the contribution of newly differentiated dentate granule cells to the network changes seen in thi

286 ously opening GABA(A)Rs, therefore, maintain dentate granule cell tonic currents in the face of low e

287 red from the dentate gyrus and the number of dentate granule cells was decreased by 70%.

288 Unexpectedly, tonic inhibition in dentate granule cells was maintained in the epileptic mi

289 hyrin, and their subcellular distribution on dentate granule cells was studied by means of confocal l

290 NA amplification (aRNA) techniques in single dentate granule cells, we demonstrate that expression of

291 possessed fewer dendritic branches, whereas dentate granule cells were hypertrophic and formed spiny

292 In the present study, rat hippocampal dentate granule cells were recorded using gramicidin per

293 mono- and di-synaptic GABAergic inputs onto dentate granule cells were reversibly depressed by exoge

294 eover, an increase in gamma-H2AX was seen in dentate granule cells, which are resistant to cell death

295 of direct, monosynaptic entorhinal input to dentate granule cells, which expresses an NMDA receptor-

296 o lead to new excitatory connections between dentate granule cells, which in turn cause electrographi

297 imary cilia in the memory function of mature dentate granule cells, which may result from abnormal mo

298 be used to label large cohorts of adult-born dentate granule cells with excellent time resolution.

299 (2) Aged female dentate granule cells with long-term estrogen replacemen

300 (3) Aged female dentate granule cells with short-term estradiol replacem